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Victoria de Lange, Marco Habegger, Marco Schmidt, János Vörös
In this publication we present an improvement to our previously introduced vertical flow microarray, the FoRe array, which capitalizes on the fusion of immunofiltration and densely packed micron test sites. Filtering samples through individual microarray spots allows us to rapidly analyze dilute samples with high-throughput and high signal-to-noise. Unlike other flowthrough microarrays, in the FoRe design samples are injected into micron channels and sequentially exposed to different targets. This arrangement makes it possible to increase the sensitivity of the microarray by simply increasing the sample volume or to rapidly reconcentrate samples after preprocessing steps dilute the analyte...
March 24, 2017: ACS Sensors
Yoed Rabin, Kenji Shimada, Purva Joshi, Anjali Sehrawat, Robert Keelan, Dona M Wilfong, James T McCormick
This paper focuses on the evaluation of a prototype for a computer-based tutoring system for prostate cryosurgery, while reviewing its key building blocks and their benchmark performance. The tutoring system lists geometrical constraints of cryoprobe placement, displays a rendered shape of the prostate, simulates cryoprobe insertion, enables distance measurements, simulates the corresponding thermal history, and evaluates the mismatch between the target region shape and a pre-selected planning isotherm. The quality of trainee planning is measured in comparison with a computer-generated plan, created for each case study by a previously developed planning algorithm, known as bubble-packing...
January 28, 2017: Proceedings of SPIE
Ying-Jun Li, Cong Yang, Gui-Cong Wang, Hui Zhang, Huan-Yong Cui, Yong-Liang Zhang
This paper presents a novel integrated piezoelectric six-dimensional force sensor which can realize dynamic measurement of multi-dimensional space load. Firstly, the composition of the sensor, the spatial layout of force-sensitive components, and measurement principle are analyzed and designed. There is no interference of piezoelectric six-dimensional force sensor in theoretical analysis. Based on the principle of actual work and deformation compatibility coherence, this paper deduces the parallel load sharing principle of the piezoelectric six-dimensional force sensor...
July 14, 2017: ISA Transactions
Paola Bonizzoni, Gianluca Della Vedova, Yuri Pirola, Marco Previtali, Raffaella Rizzi
The string graph for a collection of next-generation reads is a lossless data representation that is fundamental for de novo assemblers based on the overlap-layout-consensus paradigm. In this article, we explore a novel approach to compute the string graph, based on the FM-index and Burrows and Wheeler Transform. We describe a simple algorithm that uses only the FM-index representation of the collection of reads to construct the string graph, without accessing the input reads. Our algorithm has been integrated into the string graph assembler (SGA) as a standalone module to construct the string graph...
July 17, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
Jack Rodenburg
Robotic milking reduces labor demands on dairy farms of all sizes and offers a more flexible lifestyle for farm families milking up to 250 cows. Because milking is voluntary, barn layouts that encourage low-stress access by providing adequate open space near the milking stations and escape routes for waiting cows improve milking frequency and reduce fetching. Because lame cows attend less often, preventing lameness with comfortable stalls, clean alley floors, and effective foot bathing warrants special emphasis in robotic dairies...
July 12, 2017: Journal of Dairy Science
Jared Conley, J Stephen Bohan, Christopher W Baugh
The current health care landscape and evidence support the establishment of observation units (OUs) for safe and efficient care for observation patients. Careful attention is required in the design of OU process, location, and layout to enable optimal care and finances. Developing and maintaining protocols to guide patient selection and clinical care are critical. OU management requires a strong, collaborative leadership model, appropriate staffing, and a robust monitoring system for quality, safety, and finances...
August 2017: Emergency Medicine Clinics of North America
Mei Bai, Jianlei Sun, Owen T Denmead, Deli Chen
Accurate measurement of ammonia (NH3) emissions from livestock pens is challenging. Two micrometeorological techniques, the integrated horizontal flux (IHF) and the backward Lagrangian stochastic (bLS) dispersion techniques were used to measure NH3 emissions from an isolated cattle pen (20 × 20 m) in Victoria, Australia. The bLS technique is simple and insensitive to the presence of animals, but typically gives discontinuous measurements due to the need for target wind directions and wind conditions above accepted thresholds...
July 12, 2017: Environmental Pollution
Bumsub Ham, Minsu Cho, Cordelia Schmid, Jean Ponce
Finding image correspondences remains a challenging problem in the presence of intra-class variations and large changes in scene layout. Semantic flow methods are designed to handle images depicting different instances of the same object or scene category. We introduce a novel approach to semantic flow, dubbed proposal flow, that establishes reliable correspondences using object proposals. Unlike prevailing semantic flow approaches that operate on pixels or regularly sampled local regions, proposal flow benefits from the characteristics of modern object proposals, that exhibit high repeatability at multiple scales, and can take advantage of both local and geometric consistency constraints among proposals...
July 11, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
Pranay Jindal, Joy C MacDermid
BACKGROUND: Written health information is commonly used by health-care professionals (HCPs) to inform and assess patients in clinical practice. With growing self-management of many health conditions and increased information seeking behavior among patients, there is a greater stress on HCPs and researchers to develop and implement readable and understandable health information. Readability formulas such as Flesch Reading Ease (FRE) and Flesch-Kincaid Reading Grade Level (FKRGL) are commonly used by researchers and HCPs to assess if health information is reading grade appropriate for patients...
January 2017: Education for Health: Change in Training & Practice
Peio López-Iturri, Erik Aguirre, Leyre Azpilicueta, José Javier Astrain, Jesús Villandangos, Francisco Falcone
The advent of fully interactive environments within Smart Cities and Smart Regions requires the use of multiple wireless systems. In the case of user-device interaction, which finds multiple applications such as Ambient Assisted Living, Intelligent Transportation Systems or Smart Grids, among others, large amount of transceivers are employed in order to achieve anytime, anyplace and any device connectivity. The resulting combination of heterogeneous wireless network exhibits fundamental limitations derived from Coverage/Capacity relations, as a function of required Quality of Service parameters, required bit rate, energy restrictions and adaptive modulation and coding schemes...
July 12, 2017: Sensors
Thomas Stephen Ledger
Wikipedia ( is the largest encyclopaedia in existence. Of over five million English-language articles, about 6000 relate to Anatomy, which are viewed roughly 30 million times monthly. No work parallels the amount of attention, scope or interdisciplinary layout of Wikipedia, and it offers a unique opportunity to improve the anatomical literacy of the masses. Anatomy on Wikipedia is introduced from an editor's perspective. Article contributors, content, layout and accuracy are discussed, with a view to demystifying editing for anatomy professionals...
July 12, 2017: Journal of Anatomy
Mohammad Sarim, Manish Kumar, Rashmi Jha, Ali A Minai
Biomimetic robots have gained attention recently for various applications ranging from resource hunting to search and rescue operations during disasters. Biological species are known to intuitively learn from the environment, gather and process data, and make appropriate decisions. Such sophisticated computing capabilities in robots are difficult to achieve, especially if done in real-time with ultra- low energy consumption. Here, we present a novel memristive device based learning architecture for robots. Two terminal memristive devices with resistive switching of oxide layer are modeled in a crossbar array to develop a neuromorphic platform that can impart active real-time learning capabilities in a robot...
July 11, 2017: Bioinspiration & Biomimetics
An Liu, Godfred O Duodu, Ashantha Goonetilleke, Godwin A Ayoko
Land use is an influential factor in river sediment pollution. However, land use type alone is found to be inadequate to explain pollutant contributions to the aquatic environment since configurations within the same land use type such as land cover and development layout could also exert an important influence. Consequently, this paper discusses a research study, which consisted of an in-depth investigation into the relationship between land use type and river sediment pollution by introducing robust parameters that represent configurations within the primary land use types...
July 6, 2017: Environmental Pollution
Jia-Mei Wang, Xing-Guo Yang, Hong-Wei Zhou, Zi-Hao Wang, Jia-Wen Zhou, Yu-Feng Liang
A flexible riverbed protection called tetrahedron framed permeable weirs (TFPW) is proposed to protect riverbeds in mountainous areas from scouring. Under clear water conditions, a series of laboratory flume experiments were performed to study the effects of TFPW with different layout types on the stability of riverbeds. The objectives of this paper were to advance understanding of the role that TFPW play in the erosion process of river beds and to optimize the TFPW design for reducing velocity, promoting sediment deposition and good structural stability...
July 7, 2017: Scientific Reports
Yizhong Zhang, Yiying Tong, Kun Zhou
Decorating the surfaces of 3D printed objects with color textures is still not readily available in most consumer-level or even high-end 3D printers. Existing techniques such as hydrographics color transfer suffer from the issues of air pockets in concave regions and discoloration in overly stretched regions. We propose a novel thermoforming-based coloring technique to alleviate these problems as well as to simplify the overall procedure. Thermoforming is a widely used technique in industry for plastic thin shell product manufacturing by pressing heated plastic sheets onto molds using atmospheric pressure...
August 2017: IEEE Transactions on Visualization and Computer Graphics
Edmond J Breen
Plasma samples from 177 control and type 2 diabetes patients collected at three Australian hospitals are screened for 14 analytes using six custom-made multiplex kits across 60 96-well plates. In total 354 samples were collected from the patients, representing one baseline and one end point sample from each patient. R methods and source code for analyzing the analyte fluorescence response obtained from these samples by Luminex Bio-Plex(®) xMap multiplexed immunoassay technology are disclosed. Techniques and R procedures for reading Bio-Plex(®) result files for statistical analysis and data visualization are also presented...
2017: Methods in Molecular Biology
Daniel Lamprecht, Kristina Lerman, Denis Helic, Markus Strohmaier
In this work we study how people navigate the information network of Wikipedia and investigate (i) free-form navigation by studying all clicks within the English Wikipedia over an entire month and (ii) goal-directed Wikipedia navigation by analyzing wikigames, where users are challenged to retrieve articles by following links. To study how the organization of Wikipedia articles in terms of layout and links affects navigation behavior, we first investigate the characteristics of the structural organization and of hyperlinks in Wikipedia and then evaluate link selection models based on article structure and other potential influences in navigation, such as the generality of an article's topic...
January 2, 2017: New Rev Hypermedia Multimed
Judith Berg, Rod Hicks
BACKGROUND AND PURPOSE: Poster presentations are increasingly popular for dissemination of scientific and clinical knowledge at professional meetings; however, this professional skill is generally absent from advanced practice registered nurse (APRN) curricula and acquisition of the skill must occur in other arenas. The purpose of this article is to promote professional development by educating APRNs, students, and faculty on the essentials of poster development and presentation. METHODS: To aid in poster presentation skill development, types of posters, advantages and disadvantages, content and design, and tips to enhance these presentations are discussed...
June 28, 2017: Journal of the American Association of Nurse Practitioners
Laura Beckers, Lucianne Speth, Eugène Rameckers, Yvonne Janssen-Potten
PURPOSE: To produce a Dutch translation of the Lifestyle Assessment Questionnaire for children with cerebral palsy (LAQ-CP), adapted for cross-cultural differences. METHODS: The translation process consisted of 6 stages, following a guideline for cross-cultural adaptations including duplicate forward- and back-translations, expert group review, pilot-testing, and a process audit. RESULTS: Several adaptations to the questionnaire were required due to cross-cultural differences...
July 2017: Pediatric Physical Therapy
He Zhang, Rui Wu, Changle Li, Xizhe Zang, Xuehe Zhang, Hongzhe Jin, Jie Zhao
The tiger beetle can maintain its stability by controlling the interaction force between its legs and an unstructured terrain while it runs. The biomimetic hexapod robot mimics a tiger beetle, and a comprehensive force sensing system combined with certain algorithms can provide force information that can help the robot understand the unstructured terrain that it interacts with. This study introduces a complicated leg force sensing system for a hexapod robot that is the same for all six legs. First, the layout and configuration of sensing system are designed according to the structure and sizes of legs...
June 27, 2017: Sensors
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