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https://www.readbyqxmd.com/read/29236229/model-based-therapeutic-drug-monitoring-of-infliximab-using-a-single-serum-trough-concentration
#1
David Ternant, Christophe Passot, Alexandre Aubourg, Philippe Goupille, Céline Desvignes, Laurence Picon, Thierry Lecomte, Denis Mulleman, Gilles Paintaud
BACKGROUND AND OBJECTIVES: The pharmacokinetics of infliximab are highly variable and influence clinical response in chronic inflammatory diseases. The goal of this study was to build a Bayesian model allowing predictions of upcoming infliximab concentrations and dosing regimen adjustment, using only one concentration measurement and information regarding the last infliximab infusion. METHODS: This retrospective study was based on data from 218 patients treated with infliximab in Tours University Hospital who were randomly assigned to learning (two-thirds) or validation (one-third) data subsets...
December 13, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29235421/how-should-we-talk-about-palliative-care-death-and-dying-a-qualitative-study-exploring-perspectives-from-caregivers-of-people-with-advanced-cancer
#2
Anna Collins, Sue-Anne McLachlan, Jennifer Philip
BACKGROUND: Health professionals commonly underestimate caregiver needs for information about palliative care, death and dying and may feel poorly prepared to discuss these issues. Few studies have sought caregiver perspectives of these communication practices. AIM: To explore caregiver perspectives on communication about death, dying and the introduction to palliative care, with a view towards a series of caregiver-informed recommendations for use in clinical practice...
December 1, 2017: Palliative Medicine
https://www.readbyqxmd.com/read/29235364/patient-reported-safety-incidents-as-a-new-source-of-patient-safety-data-an-exploratory-comparative-study-in-an-acute-hospital-in-england
#3
Gerry Armitage, Sally Moore, Caroline Reynolds, Pierre-Antoine Laloë, Claire Coulson, Rosie McEachan, Rebecca Lawton, Ian Watt, John Wright, Jane O'Hara
Objectives To compare a new co-designed, patient incident reporting tool with three established methods of detecting patient safety incidents and identify if the same incidents are recorded across methods. Method Trained research staff collected data from inpatients in nine wards in one university teaching hospital during their stay. Those classified as patient safety incidents were retained. We then searched for patient safety incidents in the corresponding patient case notes, staff incident reports and reports to the Patient Advice and Liaison Service specific to the study wards...
January 1, 2017: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29235222/profile-of-advanced-nursing-practice-in-spain-a-cross-sectional-study
#4
Sonia Sevilla Guerra, Josep Miranda Salmerón, Adelaida Zabalegui
In this study, we described the profile of advanced nursing practice in Spain. A cross-sectional study design was used to explore the extent and patterns of advanced nursing practice activity within the domains of expert care planning, integrated care, interprofessional collaboration, education, research, evidence-based practice, and professional leadership. Data were collected in 2015/2016. Purposive sampling yielded a sample of 165 specialist and expert nurses employed by a dual tertiary and community hospital in an urban setting...
December 13, 2017: Nursing & Health Sciences
https://www.readbyqxmd.com/read/29234918/patients-with-dementia-in-acute-care-hospitals-a%C3%A2-cross-sectional-study-of-physicians-experiences-and-attitudes
#5
Lena Helm, Katrin Balzer, Anja Behncke, Nora Eisemann, Sascha Köpke
BACKGROUND: Patients with dementia (PwD) are a vulnerable group and caring for these patients in acute care hospitals is challenging. Structural conditions and standardized treatment procedures in hospitals often do not correspond to the needs of this patient group. Physicians may not be well prepared for caring for PwD. OBJECTIVE: This study aimed to ascertain physicians' experiences and attitudes in caring for PwD or cognitive disorders and their subjective workload...
December 12, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/29234713/promoting-early-detection-of-melanoma-during-the-mammography-experience
#6
A K Rzepecki, N Jain, Y Ali, L Chavez, J Choi, B Schlosser, E Liko-Hazizi, S M Friedewald, J K Robinson
Background: Invasive melanoma, a lethal form of skin cancer, is the seventh most common cancer in women. Factors such as a history of indoor tanning or sunburn and a personal or family history of skin cancer increase a woman's risk of developing a melanoma. Objective: Because the majority of melanomas occur in patients age 40 years or older, which is the age that is recommended for women to begin screening mammograms, the mammogram experience could be used to promote early detection of melanoma by introducing skin self-examinations (SSE) to a population of women who are already invested in preventive health...
December 2017: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/29234592/experience-of-total-scapular-excision-for-musculoskeletal-tumor-and-reconstruction-in-eastern-asian-countries
#7
Katsuhiro Hayashi, Xiaohui Niu, Xiaodong Tang, Vivek Ajit Singh, Apichat Asavamongkolkul, Akira Kawai, Norio Yamamoto, Toshiharu Shirai, Akihiko Takeuchi, Hiroaki Kimura, Shinji Miwa, Hiroyuki Tsuchiya
Total scapulectomy and reconstruction has been performed for scapular tumor, however, most of the reconstruction methods have resulted in poor functional outcomes and there is still room for improvement. Most of the reports of reconstruction after scapulectomy are from a single institution. In the present study, we investigated functional outcomes after total scapulectomy in a multicenter study in The Eastern Asian Musculoskeletal Oncology Group (EAMOG). Thirty-three patients who underwent total scapulectomy were registered at EAMOG affiliated hospitals...
November 2017: Journal of Bone Oncology
https://www.readbyqxmd.com/read/29234358/hearing-loss-screening-tool-cobra-score-for-newborns-in-primary-care-setting
#8
Watcharapol Poonual, Niramon Navacharoen, Jaran Kangsanarak, Sirianong Namwongprom, Surasak Saokaew
Purpose: To develop and evaluate a simple screening tool to assess hearing loss in newborns. A derived score was compared with the standard clinical practice tool. Methods: This cohort study was designed to screen the hearing of newborns using transiently evoked otoacoustic emission and auditory brain stem response, and to determine the risk factors associated with hearing loss of newborns in 3 tertiary hospitals in Northern Thailand. Data were prospectively collected from November 1, 2010 to May 31, 2012...
November 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29233854/efficacy-of-educational-video-game-versus-traditional-educational-apps-at-improving-physician-decision-making-in-trauma-triage-randomized-controlled-trial
#9
Deepika Mohan, Coreen Farris, Baruch Fischhoff, Matthew R Rosengart, Derek C Angus, Donald M Yealy, David J Wallace, Amber E Barnato
OBJECTIVE: To determine whether a behavioral intervention delivered through a video game can improve the appropriateness of trauma triage decisions in the emergency department of non-trauma centers. DESIGN: Randomized clinical trial. SETTING: Online intervention in national sample of emergency medicine physicians who make triage decisions at US hospitals. PARTICIPANTS: 368 emergency medicine physicians primarily working at non-trauma centers...
December 12, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29233720/a-pragmatic-randomized-comparative-effectiveness-trial-of-transitional-care-for-a-socioeconomically-diverse-population-design-rationale-and-baseline-characteristics
#10
Christine Schaeffer, Caroline Teter, Emily A Finch, Courtney Hurt, Mary Kate Keeter, David T Liss, Angela Rogers, Avani Sheth, Ronald Ackermann
Transitional care programs have been widely used to reduce readmissions and improve the quality and safety of the handoff process between hospital and outpatient providers. Very little is known about effective transitional care interventions among patients who are uninsured or with Medicaid. This paper describes the design and baseline characteristics of a pragmatic randomized comparative effectiveness trial of transitional care. Northwestern Medical Group- Transitional Care (NMG-TC) care model was developed to address the needs of patients with multiple medical problems that required lifestyle changes and were amenable to office-based management...
December 9, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29233669/using-voice-to-create-hospital-progress-notes-description-of-a-mobile-application-and-supporting-system-integrated-with-a-commercial-electronic-health-record
#11
Thomas H Payne, W David Alonso, J Andrew Markiel, Kevin Lybarger, Andrew A White
We describe the development and design of a smartphone app-based system to create inpatient progress notes using voice, commercial automatic speech recognition software, with text processing to recognize spoken voice commands and format the note, and integration with a commercial EHR. This new system fits hospital rounding workflow and was used to support a randomized clinical trial testing whether use of voice to create notes improves timeliness of note availability, note quality, and physician satisfaction with the note creation process...
December 9, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29233529/innovating-patient-care-delivery-dsrip-s-interrupted-time-series-analysis-paradigm
#12
Amrita G Shenoy, Charles E Begley, Lee Revere, Stephen H Linder, Stephen P Daiger
INTRODUCTION: Adoption of Medicaid Section 1115 waiver is one of the many ways of innovating healthcare delivery system. The Delivery System Reform Incentive Payment (DSRIP) pool, one of the two funding pools of the waiver has four categories viz. infrastructure development, program innovation and redesign, quality improvement reporting and lastly, bringing about population health improvement. BACKGROUND: A metric of the fourth category, preventable hospitalization (PH) rate was analyzed in the context of eight conditions for two time periods, pre-reporting years (2010-2012) and post-reporting years (2013-2015) for two hospital cohorts, DSRIP participating and non-participating hospitals...
December 7, 2017: Healthcare
https://www.readbyqxmd.com/read/29233386/a-national-survey-on-the-current-status-of-informatics-residency-education-in-pharmacy
#13
Anthony Blash, Connie L Saltsman, Condit Steil
BACKGROUND AND PURPOSE: Upon completion of their post-graduate training, pharmacy informatics residents need to be prepared to interact with clinical and technology experts in the new healthcare environment. This study describes pharmacy informatics residency programs within the United States. EDUCATIONAL ACTIVITY AND SETTING: Preliminary information for all pharmacy informatics residency programs was accessed from program webpages. An email was sent out to programs asking them to respond to a six-item questionnaire...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233370/female-pharmacists-career-perceptions-in-saudi-arabia-a-survey-at-an-academic-center-in-jeddah
#14
Waleed F Al Ghazzawi, Alaa Abuzaid, Ohood A Al-Shareef, Sama M Al-Sayagh
OBJECTIVES: This study aimed to describe existing patterns of female pharmacy students' perceptions and their expectations regarding employment, job sectors, salaries, difficulties, and burdens, and to understand students' long-term prospects for employment in the pharmaceutical sector. The second objective was to assess students' perceptions of their careers in the short- and long-term. METHODS: This prospective survey was conducted on female pharmacy students at King Abdulaziz University, Jeddah from January 12, 2013 through January 21, 2013...
November 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233118/risks-and-complications-of-transurethral-resection-of-bladder-tumors-in-patients-receiving-antiplatelet-and-or-anticoagulant-therapy-a-retrospective-cohort-study
#15
Tsuzumi Konishi, Satoshi Washino, Yuhki Nakamura, Masashi Ohshima, Kimitoshi Saito, Yoshiaki Arai, Tomoaki Miyagawa
BACKGROUND: Information on the safety of transurethral resection of bladder tumors (TURBT) in patients receiving anti-thromboembolic drugs is currently lacking. This study aimed to evaluate the clinical safety of TURBT in patients receiving anti-thromboembolic agents compared with patients not taking these agents and patients who interrupted their use perioperatively. METHODS: We retrospectively analyzed data for patients who underwent TURBT at Jichi Medical University Saitama Medical Center from September 2013 to August 2016...
December 12, 2017: BMC Urology
https://www.readbyqxmd.com/read/29233014/family-perceptions-of-family-nursing-in-a-magnet-institution-during-acute-hospitalizations-of-older-adult-patients
#16
Kara Misto
Family involvement during hospitalizations of older adults with chronic illnesses may benefit both patients and family. However, there is a limited amount of research focused on families of older adults managing chronic illness. This study describes family member perceptions of the relationship between family and nurses when an older adult with diabetes is hospitalized in a Magnet institution. The Calgary Family Intervention Model guided the study. A family member of 60 older adult patients completed the Family Function, Family Health, and Social Support Instrument...
December 1, 2017: Clinical Nursing Research
https://www.readbyqxmd.com/read/29232645/pre-optimization-of-spinal-surgery-patients-development-of-a-neurosurgical-enhanced-recovery-after-surgery-eras-protocol
#17
Zarina S Ali, Tracy S Ma, Ali K Ozturk, Neil R Malhotra, James M Schuster, Paul J Marcotte, M Sean Grady, William C Welch
OBJECTIVE: Despite surgical, technological, medical, and anesthetic improvements, patient outcomes following elective neurosurgical procedures can be associated with high morbidity. Enhanced recovery after surgery (ERAS) protocols are multimodal care pathways designed to optimize patient outcomes by addressing pre-, peri-, and post-operative factors. Despite significant data suggesting improved patient outcomes with the adoption of these pathways, development and implementation has been limited in the neurosurgical population...
December 8, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29232560/the-effect-of-tranexamic-acid-and-gender-on-intraoperative-bleeding-in-orthognathic-surgery-a-randomized-controlled-trial
#18
Jesper Jared Secher, Johannes Jakobsen Sidelmann, Janne Ingerlsev, Jens Jørgen Thorn, Else Marie Pinholt
PURPOSE: The purpose of this randomized trial was to measure the effect of intravenously administered tranexamic acid (TXA) on intraoperative blood loss (IOB) in patients undergoing bimaxillary orthognathic surgery (OS). MATERIALS AND METHODS: The authors designed and implemented a double-blinded placebo-controlled trial composed of patients eligible for OS at the Hospital of South West Denmark (Esbjerg, Denmark) from August 2014 through September 2016. The primary predictor variable was a single intravenous dose of TXA 1 g administered preoperatively or an equivalent saline placebo...
November 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29232179/adenotonsillectomy-for-obstructive-sleep-apnea-in-children-with-complex-chronic-conditions
#19
Reshma Amin, Theresa Holler, Indra Narang, Sharon L Cushing, Evan J Propst, Suhail Al-Saleh
Objective To estimate the prevalence of persistent obstructive sleep apnea postadenotonsillectomy in children with complex chronic conditions. Study Design A retrospective cohort study. Setting The Hospital for Sick Children Sleep laboratory. Subjects Children ≤18 years of age who had moderate to severe obstructive sleep apnea and had polysomnography pre- and postadenotonsillectomy. Methods Medical and polysomnographic data were reviewed. The prevalence of persistent obstructive sleep apnea postadenotonsillectomy was determined for the following groups: no complex chronic conditions, single-system complex chronic conditions, and multisystem complex chronic conditions...
December 1, 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29231960/prospective-validation-of-a-screening-tool-to-identify-older-adults-in-need-of-a-driving-evaluation
#20
Marian E Betz, Jason S Haukoos, Robert Schwartz, Carolyn DiGuiseppi, Deepika Kandasamy, Brenda Beaty, Elizabeth Juarez-Colunga, David B Carr
OBJECTIVES: To prospectively validate and refine the 5-item "CRASH" screening tool for identifying older drivers needing a behind-the-wheel (BTW) test. DESIGN: Prospective observational study. SETTING: Geriatric and internal medicine primary care clinics affiliated with a tertiary care hospital and a local BTW program. PARTICIPANTS: Cognitively intact drivers aged 65 and older (N = 315). MEASUREMENTS: Participants completed baseline questionnaire (including CRASH tool) and assessments and BTW test (evaluator blinded to questionnaire results) and participated in 1-month telephone follow-up...
December 12, 2017: Journal of the American Geriatrics Society
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