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Arvind Sehgal, Andra Malikiwi, Eldho Paul, Kenneth Tan, Samuel Menahem
Pulmonary hypertension (PH) and right ventricular function are the focus of cardiovascular effects of bronchopulmonary dysplasia (BPD). We assessed cardiac indexes reflecting systemic afterload and pulmonary venous back pressure as pathophysiologic factors. Cardiac parameters were measured by conventional echocardiography in 20 preterm infants with severe BPD and compared with those of 10 preterm infants with no BPD and 20 healthy term infants. In infants with severe BPD, PH was noted in 5 (25%) by tricuspid regurgitation Doppler jet ≥2...
December 2016: Pulmonary Circulation
A Sehgal, A Malikiwi, E Paul, K Tan, S Menahem
OBJECTIVE: Systemic hypertension is common among preterm infants with severe bronchopulmonary dysplasia (BPD); the exact cause is unknown. The objective of this preliminary hypothesis generating study was to examine systemic arterial structure and vasomotor function in a cohort of preterm infants with severe BPD, using a cohort of preterm infants without BPD and a cohort of term infants for comparison. STUDY DESIGN: After obtaining informed consent, we measured aortic wall thickness and vasomotor function by ultrasonography in 20 infants with severe BPD, 7 infants with no BPD, and compared them with 20 healthy term infants...
July 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
Arvind Sehgal, Andra Malikiwi, Eldho Paul, Kenneth Tan, Samuel Menahem
BACKGROUND: While cor pulmonale has been noted in infants with bronchopulmonary dysplasia (BPD), information on right ventricular (RV) function is limited. OBJECTIVE: To assess RV function in infants with severe BPD and ascertain correlation with respiratory outcomes. METHODS: We prospectively assessed RV function using tissue Doppler imaging (TDI), 2D fractional area change (FAC), M-mode tricuspid annular plane systolic excursion (TAPSE) and myocardial performance index (MPI) using echocardiography...
2016: Neonatology
Afif El-Khuffash, Adam T James, John David Corcoran, Patrick Dicker, Orla Franklin, Yasser N Elsayed, Joseph Y Ting, Arvind Sehgal, Andra Malikiwi, Andrei Harabor, Amuchou S Soraisham, Patrick J McNamara
OBJECTIVES: To test the hypothesis that a patent ductus arteriosus (PDA) severity score (PDAsc) incorporating markers of pulmonary overcirculation and left ventricular (LV) diastolic function can predict chronic lung disease or death before discharge (CLD/death). STUDY DESIGN: A multicenter prospective observational study was conducted for infants <29 weeks gestation. An echocardiogram was carried out on day 2 to measure PDA diameter and maximum flow velocity, LV output, diastolic flow in the descending aorta and celiac trunk, and variables of LV function using tissue Doppler imaging...
December 2015: Journal of Pediatrics
Andra Malikiwi, Charlene Roufaeil, Kenneth Tan, Arvind Sehgal
UNLABELLED: Indomethacin has been the mainstay for medical closure of patent ductus arteriosus. With its discontinuation, many units shifted to the use ibuprofen. We compared the therapeutic efficacy (successful closure, a priori defined as complete closure or >50% reduction in size) and the impact of the two drugs on neonatal morbidities. Two time epochs were analysed (IV indomethacin, January 2008 to November 2010, and IV ibuprofen lysine, November 2010 to September 2013). Demographic, clinical and echocardiographic data was compared...
May 2015: European Journal of Pediatrics
Andra Malikiwi, Arun Sasi, Kenneth Tan, Arvind Sehgal
UNLABELLED: Vasopressin is emerging as a therapeutic adjunct option towards treatment of shock states in the pediatric population. Its effects on pulmonary vasculature are less well understood. This report describes a 5-month-old infant with nitric oxide-unresponsive pulmonary hypertension, oxygenation failure, and systemic hypotension. Vasopressin therapy improved oxygenation and blood pressure and biventricular function, allowing weaning of nitric oxide and inotropic support. No decrease in coronary flow was noted...
December 2014: European Journal of Pediatrics
A Malikiwi, B Elnazir
No abstract text is available yet for this article.
June 2012: Irish Medical Journal
T R Leahy, A Malikiwi, M Cafferkey, K M Butler
AIMS: Imported childhood malaria has never been studied in Ireland. We aimed to document the incidence and species of malaria in children presenting to paediatric hospitals in Dublin and to examine management and outcome measures. METHODS: Subjects were identified through laboratory archives from the three paediatric hospitals in Dublin. Clinical data were extracted retrospectively from clinical and laboratory records. RESULTS: As much as 67 episodes of malaria occurred in 66 children...
September 2009: Irish Journal of Medical Science
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