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Cutaneous T cell Lymphoma

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https://www.readbyqxmd.com/read/29469745/oral-involvement-of-cutaneous-t-cell-lymphoma
#1
Jason Schoenfeld, Julia Accetta
Methylisothiazolinone (MI) is commonly used as a preservative in personal care products and is a frequent cause of allergic contact dermatitis. We present a patient with allergic contact dermatitis caused by MI in hair care products and discuss this allergen to bring attention to this common cause of contact dermatitis, and to highlight its frequent use in hair care products. If allergy to MI is suspected, testing should be performed to this individual preservative, as testing solely for the combination preservative, methylisothiazolinone/methylchloroisothiazolinone (Kathon CG®), may miss many cases of MI allergy...
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29469744/folliculin-mutation-negative-trichodiscomas-in-a-patient-with-multiple-endocine-neoplasia-type-i-syndrome
#2
Jennifer E Yeh, Steven R Tahan, Susan Burgin
Mycosis fungoides (MF) is the most common cutaneous T cell lymphoma that involves the oral mucosal. The manifestation of lesions within the oral cavity generally correlates with a poor prognosis. Management of MF includes skin directed therapies and localized radiation treatment, with systemic biologic therapies and chemotherapy used for more advanced stages. The clinical and histologic features of MF in a patient with oral disease are reviewed.
August 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29460964/comparison-between-8-methoxypsoralen-and-5-aminolevulinic-acid-in-killing-t-cells-of-photopheresis-patients-ex-vivo
#3
Toril Holien, Odrun Arna Gederaas, Sagar Ramesh Darvekar, Eidi Christensen, Qian Peng
BACKGROUND AND OBJECTIVE: Extracorporeal photopheresis (ECP), an established modality for cutaneous T-cell lymphoma (CTCL) and graft-versus-host disease, involves ex vivo treatment of isolated leukocytes of a patient with the photosensitizing drug 8-methoxypsoralen (8-MOP) and ultraviolet-A (UV-A) exposure before reinfusion back to the patient. However, 8-MOP binds to both diseased and normal cells and thus kills both types of the cells after UV-A illumination with little selectivity...
February 20, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29455635/the-efficacy-and-safety-of-methotrexate-versus-interferon-in-cutaneous-t-cell-lymphomas
#4
Thevaki Wain, Alexandra Pavli, Jillian Wells, Pablo Fernandez-Peñas
OBJECTIVES: Methotrexate and interferon have been used in the treatment of cutaneous T-cell lymphomas of various subtypes. We review our experience of methotrexate and interferon use in our patients with cutaneous T-cell lymphoma at a tertiary hospital. MATERIALS AND METHODS: Medical records of patients over four years were reviewed. We describe the dosages, time to response, response rates, side effects, progression rate and reasons for discontinuation. RESULTS: Response rate was significantly higher in the IFN group than MTX group (86...
February 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29451670/-it-s-a-traumatic-illness-traumatic-to-witness-a-qualitative-study-of-the-experiences-of-bereaved-family-caregivers-of-patients-with-cutaneous-t-cell-lymphoma
#5
D Orlowska, L E Selman, T Beynon, E Radcliffe, S Whittaker, F Child, R Harding
BACKGROUND: Cutaneous T-cell lymphomas (CTCL) are rare cancers which can be difficult to diagnose, are incurable and adversely affect quality of life, particularly in advanced disease. Families often provide care, but little is known about their experiences or needs while caring for their relative with advanced disease or in bereavement. OBJECTIVES: To explore the experiences of bereaved family caregivers of patients with CTCL. METHODS: Single semi-structured qualitative interviews were conducted with bereaved family caregivers of patients with CTCL recruited via a supra-regional CTCL clinic...
February 16, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29451308/apheresis-buffy-coat-collection-without-photoactivation-has-no-effect-on-apoptosis-cell-proliferation-and-total-viability-of-mononuclear-cells-collected-using-photopheresis-systems
#6
Zbigniew M Szczepiorkowski, Christine A Burnett, Larry J Dumont, Sunil H Abhyankar
BACKGROUND: Extracorporeal photopheresis (ECP) has been approved for the treatment of advanced cutaneous T-cell lymphoma since 1988. While the precise mechanisms resulting in clinical effects are not fully understood, the photoactivation of mononuclear cells (MNCs) using ultraviolet A (UVA) light and methoxsalen is believed to be the predominant initiating process. The effects of MNC passage through the instrument without photoactivation are unknown. The objective of this study was to evaluate the effect of cell processing through the photopheresis instruments on MNCs...
February 16, 2018: Transfusion
https://www.readbyqxmd.com/read/29447636/a-diagnostically-challenging-case-of-cd8-primary-cutaneous-gamma-delta-t-cell-lymphoma
#7
Michelle A Pitch, Kevin H Kim, Trey Manning, Bruce R Smoller, Henry K Wong, Jennifer R Kaley
Primary cutaneous gamma/delta T-cell lymphoma (PCγδTCL) is a rare form of cutaneous lymphoma characterized by abnormal clonal proliferation of mature, activated gamma-delta T cells expressing the γδ heterodimer of the T-cell receptor (TCR). As an entity, PCγδTCL has recently undergone diagnostic revision since its introduction in the 2008 WHO classification of cutaneous lymphomas and confirmedin 2016. Nonetheless, diagnosis remains difficult both clinically and histologically, given its broad range of clinical manifestations and immunohistochemical phenotypes...
November 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/29444372/primary-cutaneous-small-medium-sized-pleomorphic-t-cell-lymphoproliferative-disorder-shows-a-common-vascular-pattern-at-dermoscopy
#8
Alessandro Pileri, Claudio Agostinelli, Elena Sabattini, Michela Tabanelli, Valeria Gaspari, Miriam Leuzzi, Annalisa Patrizi, Francesco Savoia
Primary cutaneous small/medium-sized pleomorphic T-cell lymphoproliferative disorder (PCSM-TCLPD) is a rare and indolent primary cutaneous T-cell lymphoma variant [1], usually presenting as a solitary nodule or plaque in the head and neck [2] or rarely as multiple lesions in anatomic areas apart from head and neck [2]. Histology reveals the presence of a dense dermal infiltrate of CD4+, CD8-, small/medium pleomorphic cells [2] intermingled with reactive cells. Surgical or radiotherapic approach are the preferred option, while oral doxycycline has been suggested in cases with multiple lesions [2-3]...
February 14, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29443405/vascular-access-considerations-for-extracorporeal-photopheresis
#9
REVIEW
Jill Adamski
Extracorporeal photopheresis is an immunomodulatory therapy indicated for patients with cutaneous T-cell lymphoma, graft-versus-host disease, and heart or lung allograft rejection. Whole blood from the patient is drawn into the photopheresis instrument where it is separated into its components. Plasma, red blood cells, and the treated buffy coat are subsequently returned to the patient. Consistent, adequate blood flow is necessary to successfully complete the procedure. Vascular access options for photopheresis include peripheral vein cannulation, tunneled central venous catheters, and subcutaneous ports...
February 2018: Transfusion
https://www.readbyqxmd.com/read/29442161/allogeneic-hematopoietic-stem-cell-transplantation-in-primary-cutaneous-t-cell-lymphoma
#10
Laura Cudillo, Raffaella Cerretti, Alessandra Picardi, Benedetta Mariotti, Gottardo De Angelis, Maria Cantonetti, Massimiliano Postorino, Eleonora Ceresoli, Giovanna De Santis, Daniela Nasso, Francesco Pisani, Enrico Scala, Fabio Di Piazza, Alessandro Lanti
In our retrospective study, 16 patients affected by advanced cutaneous T cell lymphoma (CTCL) underwent allogeneic hematopoietic stem cell transplantation (HSCT). Two patients (12.5%) were in complete remission (CR), nine (56.3%) in partial remission (PR), and five (31.2%) with active disease. The patients were transplanted from an HLA-identical (n = 7) from a mismatched (n = 1) or haploidentical (n = 1) sibling, from matched unrelated donor (n = 5), or from a single cord blood unit (n = 2). Conditioning regimen was standard myeloablative in 6 patients and at reduced intensity in 10...
February 13, 2018: Annals of Hematology
https://www.readbyqxmd.com/read/29440874/clinical-potential-of-mechlorethamine-gel-for-the-topical-treatment-of-mycosis-fungoides-type-cutaneous-t-cell-lymphoma-a-review-on-current-efficacy-and-safety-data
#11
REVIEW
Kendall Liner, Celeste Brown, Laura Y McGirt
Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. The authors in this review found that while the gel formulation may result in a decrease of allergic contact dermatitis, this advantage has been replaced by a higher number of irritant contact reactions and a decrease in complete response rate...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29438091/a-phase-i-dose-escalation-study-of-clofarabine-in-patients-with-relapsed-or-refractory-low-grade-or-intermediate-grade-b-cell-or-t-cell-lymphoma
#12
Francine Marie Foss, Terri Parker
LESSONS LEARNED: Clofarabine can be active in relapsed and refractory lymphoid malignancies on a weekly dosing schedule.Responses were seen in patients with T-cell lymphomas, including cutaneous T-cell lymphoma, but not in patients with aggressive B-cell lymphomas. BACKGROUND: Clofarabine is a second-generation purine nucleoside analog currently approved for the treatment of pediatric relapsed or refractory acute lymphoblastic leukemia. In adults, clofarabine has been investigated in several phase I and II trials as a single agent and in combination for relapsed or refractory acute leukemia...
February 7, 2018: Oncologist
https://www.readbyqxmd.com/read/29427587/highly-sensitive-virome-capture-sequencing-technique-vircapseq-vert-identifies-partial-non-coding-sequences-but-no-active-viral-infection-in-cutaneous-t-cell-lymphoma
#13
Mary E Anderson, Dorottya Nagy-Szakal, Komal Jain, Christina C Patrone, Mark G Frattini, W Ian Lipkin, Larisa J Geskin
No abstract text is available yet for this article.
February 7, 2018: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29423061/chronic-activation-profile-of-circulating-cd8-t-cells-in-s%C3%A3-zary-syndrome
#14
Marina Passos Torrealba, Kelly Cristina Manfrere, Denis R Miyashiro, Josenilson F Lima, Luana de M Oliveira, Nátalli Z Pereira, Jade Cury-Martins, Juliana Pereira, Alberto J S Duarte, Maria N Sato, José A Sanches
Sézary syndrome (SS) is a leukemic variant of cutaneous T cell lymphoma (CTCL), and the neoplastic CD4+ T cells of SS patients undergo intense clonal proliferation. Although Sézary cells have been studied extensively, studies on adaptive immunity regarding CD8+T cells are scarce. This study aimed to investigate activation marker expression in CD8+ T cells according to the differentiation stages and IL-7/IL7Rα axis responses of patients with SS. Moreover, this study aimed to verify the soluble forms of CD38, sCD127 and IL-7 in serum...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29422815/the-role-of-regulatory-t-cells-and-genes-involved-in-their-differentiation-in-pathogenesis-of-selected-inflammatory-and-neoplastic-skin-diseases-part-iii-polymorphisms-of-genes-involved-in-tregs-activation-and-function
#15
REVIEW
Bogusław Nedoszytko, Małgorzata Sokołowska-Wojdyło, Joanna Renke, Magdalena Lange, Piotr Trzonkowski, Michał Sobjanek, Aneta Szczerkowska-Dobosz, Marek Niedoszytko, Aleksandra Górska, Jan Romantowski, Jarosław Skokowski, Leszek Kalinowski, Roman J Nowicki
Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. The abnormal function of Tregs is relevant to the pathogenesis of several skin diseases like psoriasis, atopic dermatitis, systemic lupus erythematosus, cutaneous T-cell lymphomas, and skin cancer and is also important in rheumatoid arthritis, diabetes and other autoimmune diseases. In this review, we will summarize the role of mutations and/or polymorphisms of genes involved in Tregs development, and functions in the pathogenesis of selected skin diseases...
December 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/29413580/serum-metabolite-profiling-of-cutaneous-t-cell-lymphoma-based-on-a-multiplatform-approach
#16
Guoting Jiang, Xiaoyan Shen, Hongyan Kang, Kejia Li, Jie Zheng, Yunqiu Yu
Cutaneous T-cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma with a difficult early diagnosis. The overall annual age-adjusted incidence of CTCL had consistently increased to around 10.2 cases per million persons. However, our knowledge regarding its mechanism of disease origin and progression remains unclear. In this study, serum samples from 31 CTCL patients and 31 matched healthy volunteers were analyzed in depth to screen metabolites capable of differentiating CTCL from controls. To obtain a higher coverage of metabolome with various hydrophilicity, a multiplatform approach with GC-MS and UHPLC-QTOF-MS has been employed...
January 31, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29405482/molecular-genetic-analyses-of-human-endogenous-retroviral-elements-belonging-to-the-herv-p-and-r-family-in-primary-cutaneous-t-cell-lymphomas
#17
Massimiliano Bergallo, Paolo Fava, Ilaria Galliano, Mauro Novelli, Paola Montanari, Valentina Daprà, Marco Rassu, Pietro Quaglino, Maria Teresa Fierro
Mycosis fungoides (MF) is characterized by longstanding, scaly patch lesions preferentially involving the buttocks and body areas infrequently exposed to sunlight and by a slow evolution over years from patches to plaques and eventually tumors or erythroderma. Lymph node and visceral involvement, as well as large cell transformation, frequently occur in the late stages of the disease [1]. Sézary syndrome (SS) is an erythrodermic cutaneous T-cell lymphoma (CTCL) with leukemic involvement, an aggressive clinical behavior and poor prognosis [2]...
February 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29391350/overcoming-resistance-to-dna-targeted-agents-by-epigenetic-activation-of-schlafen-11-slfn11-expression-with-class-i-histone-deacetylase-inhibitors
#18
Sai Wen Tang, Anish Thomas, Junko Murai, Jane Trepel, Susan E Bates, Vinodh N Rajapakse, Yves Pommier
PURPOSE: Schlafen 11 (SLFN11), a putative DNA/RNA helicase is a dominant genomic determinant of response to DNA damaging agents and is frequently not expressed in cancer cells. Whether histone deacetylase (HDAC) inhibitors can be used to release SLFN11 and sensitize SLFN11-inactivated cancers to DNA-targeted agents is tested here. EXPERIMENTAL DESIGN: SLFN11 expression was examined in The Cancer Genome Atlas (TCGA), in cancer cell line databases and in patients treated with romidepsin...
February 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29391313/post-transplant-malignancies-in-pediatric-liver-transplant-recipients-experience-of-two-centers-in-turkey
#19
Miray Karakoyun, Şebnem Önen, Maşallah Baran, Murat Çakır, Çiğdem Ömür Ecevit, Murat Kılıç, Mehmet Kantar, Serap Aksoylar, Funda Özgenç, Sema Aydoğdu
BACKGROUND/AIMS: A liver transplant is the preferred treatment for patients with end-stage liver disease, as it usually results in longterm survival. However, due to the use of chronic immunosuppressive therapy, which is necessary to prevent rejection, de novo cancer is a major risk after transplantation. The aim of this study was to assess the incidence of post-transplant malignancies in children after liver transplantations. MATERIALS AND METHODS: The study group consisted of 206 liver transplant recipients, with no history of cancer, including hepatocellular carcinoma, in two liver transplantation centers in Turkey between 1997 and 2015...
January 2018: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/29380871/extranodal-natural-killer-t-cell-lymphoma-nasal-type-in-senegal
#20
Moussa Diallo, Assane Diop, Boubacar A Diatta, Maodo Ndiaye, Nicolas Ortonne, Mame T Dieng
INTRODUCTION: The distribution of extranodal NK/T-cell lymphoma (ENKTCL) is highly inhomogeneous throughout the world. In Sub-Saharan Africa, despite the precocity of Epstein-Barr virus (EBV) infection and its endemicity, ENKTCL remains exceptionally reported. The purpose of this study was to report the epidemiological, clinical, paraclinical, and evolutionary characteristics of ENKTCL at the Aristide LeDantec University Hospital in Dakar, Senegal. METHODOLOGY: A 5-year retrospective review of all patients with histopathological, immunohistochemical, and in situ hybridization proven cutaneous lymphomas RESULTS: We collected seven cases corresponding to a frequency of 1...
January 30, 2018: International Journal of Dermatology
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