David Fuentes-Ríos, Alba Ortigosa, Francisco Quiñonero, Consolación Melguizo, Raul Ortiz, José Prados, Amelia Díaz, J Manuel López-Romero
A new eusdesmane sesquiterpenoid, characterized as 3,5,8a-trimethyl-8-oxo-4,4a,5,6,7,8,8a,9-octahydronaphtho[2,3- b ]furan-5-yl acetate ( 1 ), has been isolated from the rhizomes of the South African variety of wild ginger ( Siphonochilus aethiopicus (Schweinf) B. L. Burtt). The compound was obtained by silica gel column chromatography. Its structure was elucidated by nuclear magnetic resonance spectroscopy (NMR) and mass-spectrometric (MS) analyses, including 1D-, 2D-NMR, and HR-LCMS. We also investigated the cytotoxic effect of 1 on a panel of cancer cell lines, human breast, pancreas, lung, colon, and central nervous system cancer lines...
April 2, 2024: ACS Omega