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renovascular hypertension

Xiaohang Li, Jialin Zhang, Yiman Meng, Lei Yang, Fengshan Wang, Baifeng Li, Xitong Zhang
BACKGROUND: Renal transplant is the preferred treatment option for these patients with end-stage renal disease. Transplant renal artery stenosis (TRAS) is one of the most common and serious vascular complications after renal transplantation, and most of the TRAS occurred in the anastomosis. The complication must be diagnosed and treated timely, otherwise the function of transplanted kidney may be losed. CASE PRESENTATION: A 46-year-old male with end-stage renal disease of unknown cause received a cadaveric renal transplant one year ago...
March 9, 2018: BMC Nephrology
Hyungwoo Ahn, Eun Ju Chun, Hak Jong Lee, Sung Il Hwang, Dong-Ju Choi, In-Ho Chae, Kyung Won Lee
Although the causes of hypertension are usually unknown, about 10% of the cases occur secondary to specific etiologies, which are often treatable. Common categories of secondary hypertension include renal parenchymal disease, renovascular stenosis, vascular and endocrinologic disorders. For diseases involving the renal parenchyma and adrenal glands, ultrasonography (US), computed tomography (CT) or magnetic resonance (MR) imaging is recommended. For renovascular stenosis and vascular disorders, Doppler US, conventional or noninvasive (CT or MR) angiography is an appropriate modality...
March 2018: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
V M Chertok, A E Kotsyuba, M S Starceva
AIM: To obtain the data on the spatial relationships between catecholamine (TH-positive) and nitroxidergic (nNOS-positive) neurons in vasomotor nuclei of the medulla in different periods of hypertension development. MATERIAL AND METHODS: The experiment was performed on male Wistar rats (n=45) with induced renovascular hypertension (RVH). TH and nNOS in neurons of solitary tract nuclei, reticular small-and giant cell nuclei were detected using immunohistochemical methods...
2018: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
Konstantinos Stavropoulos, Konstantinos P Imprialos, Vasilios G Athyros, Michael Doumas
No abstract text is available yet for this article.
February 16, 2018: Journal of Clinical Hypertension
Sherliane C Pereira, Juliana M Parente, Vanessa A Belo, Atlante S Mendes, Natália A Gonzaga, Gabriel T do Vale, Carla S Ceron, José Eduardo Tanus-Santos, Carlos R Tirapelli, Michele M Castro
BACKGROUND AND AIMS: Increased activity of matrix metalloproteinase (MMP)-2 is observed in aortas of different models of hypertension, and its activation is directly mediated by oxidative stress. As quercetin is an important flavonoid with significant antioxidant effects, the hypothesis here is that quercetin will reduce increased MMP-2 activity by decreasing oxidative stress in aortas of hypertensive rats and then ameliorate hypertension-induced vascular remodeling. METHODS: Male two-kidney one-clip (2K1C) hypertensive Wistar rats and controls were treated with quercetin (10 mg/kg/day) or its vehicle for three weeks by gavage...
January 31, 2018: Atherosclerosis
Nellie Della Schiava, Patrick Lermusiaux
In the name of the first author, the element "Della" was misinterpreted as a second given name. In fact, it is part of her surname.
February 5, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Fu Congrui, Li Na, Yuan Yujia, Wang Ri, Chen Jinting, Yang Jing, Guo Zan, Wang Sheng, Zhang Yi, Liu Yixian, Dong Jinghui
Many studies have demonstrated that chronic intermittent hypobaric hypoxia (CIHH) can reduce blood pressure in spontaneously hypertensive rats and renovascular hypertensive (RVH) rats in which endothelial dysfunction is determined as a critical factor. However, whether CIHH can regulate vasodilation of the aorta in RVH rats remains unknown. The purpose of this study was to investigate the effect of CIHH on impaired relaxation of the aorta in the two-kidney one-clip (2K1C) RVH rat model. The results showed CIHH improved the impaired endothelium-dependent relaxation in the 2K1C rat aorta...
February 3, 2018: Canadian Journal of Physiology and Pharmacology
Weiwei Cai, Zhenpeng Zhang, Yiqi Huang, Haijian Sun, Liying Qiu
The kidney is an important organ in the regulation of blood pressure, and it is also one of the primary target organs of hypertension. Kidney damage in response to hypertension eventually leads to renal insufficiency. The authors previously demonstrated that vaccarin exhibits a protective role in endothelial injury. However, the effects of vaccarin on the two-kidney, one clip (2K1C) renovascular hypertension model and subsequent kidney injury have yet to be fully elucidated. The present study was designed to investigate the roles and mechanisms of vaccarin in attenuating hypertension and whether vaccarin had beneficial effects on kidney injury...
January 2018: Experimental and Therapeutic Medicine
Inna N Lobeck, Amir M Alhajjat, Phylicia Dupree, John M Racadio, Mark M Mitsnefes, Rebekah Karns, Greg M Tiao, Jaimie D Nathan
INTRODUCTION: Renal artery occlusive disease is poorly characterized in children; treatments include medications, endovascular techniques, and surgery. We aimed to describe the course of renovascular hypertension (RVH), its treatments and outcomes. METHODS: We performed literature review and retrospective review (1993-2014) of children with renovascular hypertension at our institution. Response to treatment was defined by National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents at most-recent follow-up...
December 24, 2017: Journal of Pediatric Surgery
Luyun Fan, Wenjun Ma, Huimin Zhang, Jun Cai
RATIONALE: Iliac arterial fibromuscular dysplasia (FMD) was rarely reported and its demographic, clinical, and imaging features have not been precisely described resulting in uncertain therapeutic methods. PATIENT CONCERNS: A 31-year-old man was referred because of 3-month-ago onset hypertension, low serum potassium, and a small-sized right kidney with normal renal artery under ultrasound examination. This patient was suspected of primary aldosteronism, whereas spirolactone was poorly effective...
December 2017: Medicine (Baltimore)
Ken D O'Halloran
The homeostatic regulation of blood pressure depends on an exquisite interplay between multimodal sensors, several brain regions and long-range control systems that serve to maintain and defend cardiovascular constancy. This article is protected by copyright. All rights reserved.
January 26, 2018: Experimental Physiology
George Madubueze, Emmanuel Ugwa
Background: Hypertensive nephropathy is an important medical problem among the black African population. Early detection of renovascular changes using ultrasonography can provide opportunity for immediate intervention towards preventing or at least delaying the irreversible hypertensive nephropathy. Purpose: To compare intrarenal resistive index (RI) in healthy normotensive and hypertensive adults in Kano, Nigeria. Material and Methods: A prospective comparative study of intrarenal RI using ultrasound in 150 hypertensives and 150 normotensive controls...
January 2018: Acta Radiologica Open
Alisson Martins-Oliveira, Danielle A Guimaraes, Carla S Ceron, Elen Rizzi, Diogo M M Oliveira, Carlos R Tirapelli, Dulce E Casarini, Fernanda B Fernandes, Lucas C Pinheiro, Jose E Tanus-Santos
Renin-angiotensin system activation promotes oxidative stress and endothelial dysfunction. However, no previous study has examined the effects of the renin inhibitior aliskiren, either alone or combined with angiotensin II type 1 antagonists on alterations induced by two-kidney, one-clip (2K1C) hypertension. We compared the vascular effects of aliskiren (50mg/kg/day), losartan (10mg/kg/day), or both by gavage for 4 weeks in 2K1C and control rats. Treatment with losartan, aliskiren, or both exerted similar antihypertensive effects...
January 10, 2018: European Journal of Pharmacology
Camila F Roncari, Rafaela M Barbosa, Regina C Vendramini, Laurival A De Luca, José V Menani, Eduardo Colombari, Débora S A Colombari
Renovascular hypertensive 2-kidney, 1-clip (2K1C) rats have an increased activity of the renin-angiotensin system and an initial transitory increase in daily water and NaCl intake. However, the dipsogenic and natriorexigenic responses to angiotensin II (ANG II) have not been tested yet in 2K1C rats. Therefore, in the present study, we evaluated water and 0.3 M NaCl intake induced by water deprivation (WD)-partial rehydration (PR) or intracerebroventricular (icv) ANG II in 2K1C rats. In addition, the cardiovascular changes to these treatments were also evaluated...
January 2, 2018: Peptides
Lisa Belaid, Sahar Bayat-Makoei, Brigitte Laguerre, Cécile Vigneau
OBJECTIVE: The aim of this study is to measure the monitoring and the incidence of renovascular effects of angiogenesis inhibitors in real population. METHOD: Are included in this descriptive, monocentric, practical study, patients of 18 years old and more, orally treated by angiogenesis inhibitors and monitored in consultation by clinician nurses. The main interest variable is the incidence of hypertension at three months of treatment. RESULTS: From January, 2011 to July, 2014, 324 patients have been included, whose 53% are men...
December 26, 2017: Néphrologie & Thérapeutique
Usman Mahmood, Helen G Healy, Adrian Kark, Anne Cameron, Zaimin Wang, Rajitha Abeysekera, Wendy E Hoy
BACKGROUND: Aim of our study is to describe, in people with CKD, the demographic and clinical characteristics and outcomes with increasing age. The prevalence of CKD in Western populations, where longevity is the norm, is about 10-15%, but how age influence different characteristics of patients with CKD is largely not known. METHODS: One thousand two hundred sixty-five patients enrolled in the CKD.QLD registry at the Royal Brisbane and Women's Hospital were grouped according to age at consent i...
December 28, 2017: BMC Nephrology
Yeonhee Lee, Young Shin Lim, Sang Taek Lee, Heeyeon Cho
BACKGROUND: Renovascular hypertension (RVH) accounts for 5-10% of pediatric hypertension, and can be associated with underlying disease involving other organs. The purpose of this study was to evaluate the clinical characteristics and assess the treatment outcomes of Korean pediatric patients with RVH. METHODS: The medical records of 25 Korean pediatric patients with RVH were retrospectively reviewed. RESULTS: Twenty-four patients had underlying disease, and the most common cause was Moyamoya disease (MMD) (n = 10, 40%)...
December 27, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
Sarawoot Bunbupha, Chutamas Wunpathe, Putcharawipa Maneesai, Thewarid Berkban, Upa Kukongviriyapan, Veerapol Kukongviriyapan, Parichat Prachaney, Poungrat Pakdeechote
Carthamus tinctorius L. (CT) is widely used in Asian countries as a beverage and in folk medicine. The effects of CT extract on hemodynamics, vascular remodeling, the renin-angiotensin system (RAS) and oxidative stress in the two-kidney, one clip (2K-1C) hypertensive rat model were investigated. Renovascular hypertension was induced in male Sprague-Dawley rats and were treated with CT extract (500mg/kg/day) or captopril (5mg/kg/day) or vehicle for four weeks. CT extract or captopril reduced blood pressure, hindlimb vascular resistance, and increased hindlimb blood flow in 2K-1C hypertensive rats (p <0...
December 20, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
Minako Inoue, Kiyoshi Matsumura, Yoshie Haga, Yasuo Kansui, Kenichi Goto, Toshio Ohtsubo, Takanari Kitazono
The relationship between the renin-angiotensin aldosterone system and short-term blood pressure variability has not been well elucidated. Here, we investigated whether blood pressure variability determined by ambulatory blood pressure monitoring differed among patients with primary aldosteronism (PA), renovascular hypertension (RVHT), and essential hypertension (EHT). We examined 25 patients with PA, 28 patients with RVHT, and 18 patients with EHT. Ambulatory blood pressure monitoring was conducted in all patients...
December 15, 2017: Clinical and Experimental Hypertension: CHE
Rhanany Alan Calloi Palozi, Maysa Isernhagen Schaedler, Cleide Adriane Signor Tirloni, Aniely Oliveira Silva, Francislaine Aparecida Dos Reis Lívero, Roosevelt Isaias Carvalho Souza, Ariany Carvalho Dos Santos, Thiago Bruno Lima Prando, Lauro Mera de Souza, Arquimedes Gasparotto Junior
Although Acanthospermum hispidum is used in Brazilian folk medicine as an antihypertensive, no study evaluated its effects on a renovascular hypertension and ovariectomy model. So, this study investigated the mechanisms involved in the antihypertensive effects of an ethanol-soluble fraction obtained from A. hispidum (ESAH) using two-kidney-one-clip hypertension in ovariectomized rats (2K1C plus OVT). ESAH was orally administered at doses of 30, 100, and 300 mg/kg, daily, for 28 days, after 5 weeks of surgery...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
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