Mohammadreza Azimi, Sanghee Cho, Emir Bozkurt, Elizabeth McDonough, Batuhan Kisakol, Anna Matveeva, Manuela Salvucci, Andreas Lindner, Heiko Dussmann, Jinru Shia, Simon McDade, Daniel B Longley, Fiona Ginty, Jochen H M Prehn
Colorectal cancer (CRC) is one of the most frequently occurring cancers, but prognostic biomarkers identifying patients at risk of recurrence are still lacking. In this study, we aimed to investigate in more detail the spatial relationship between intratumoural T cells, cancer cells, and cancer cell hallmarks, as prognostic biomarkers in stage III colorectal cancer patients. We conducted multiplexed imaging of 56 protein markers at single cell resolution on resected fixed tissue from stage III CRC patients who received adjuvant 5-fluorouracil-based chemotherapy...
February 1, 2024: bioRxiv