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Jun Wang, Liu Yang, Lu Yu, Yi-Yin Wang, Rui Chen, Jing Qian, Zhi-Peng Hong, Xiao-San Su
While monocytic myeloid-derived suppressor cells (M-MDSCs) have been reported to induce the development of regulatory T cells (Treg), little is known about their correlation with Treg during perioperative period. Here, we demonstrated that the M-MDSCs expressing CD11b+CD33+HLA-DR-CD14+ in lung cancer patients after thoractomy significantly increased in comparison with preoperation, and their accumulation linearly correlated with an increase in Treg. Surgery-induced M-MDSCs, in addition to have high arginase activity, were more efficient in suppressing T-cell proliferation...
March 7, 2017: Oncotarget
Julian J Nesbitt, George Mori, Charlotte Mason-Apps, George Asimakopoulos
OBJECTIVE: Minimally invasive coronary artery bypass surgery performed through a left thoracotomy has potential benefits over conventional sternotomy, including reduced surgical trauma, faster recovery and potential improvement in quality of life. This study is a prospective assessment of quality of life in patients undergoing off-pump coronary bypass by median sternotomy and left anterior thoracotomy. METHODS: Quality of life was assessed by the EuroQoL questionnaire, with additional questions on dyspnoea, angina, wound pain and scar aesthetics...
January 2017: Perfusion
Ching-Hsia Hung, Jeffrey Chi-Fei Wang, Gary R Strichartz
Chronic pain after surgery limits social activity, interferes with work, and causes emotional suffering. A major component of such pain is reported as resting or spontaneous pain with no apparent external stimulus. Although experimental animal models can simulate the stimulus-evoked chronic pain that occurs after surgery, there have been no studies of spontaneous chronic pain in such models. Here the conditioned place preference (CPP) paradigm was used to reveal resting pain after experimental thoracotomy. Male Sprague Dawley rats received a thoracotomy with 1-hour rib retraction, resulting in evoked tactile hypersensitivity, previously shown to last for at least 9 weeks...
September 2015: Journal of Pain: Official Journal of the American Pain Society
Bo Yang, Yang Liu, Weimin Dai, Xiangyang Chu, Yu'e Sun, Yuqi Wang, Tao Wang, Zhiqiang Xue, Ming Zhao
OBJECTIVE: To explore the impact and reasons of conversion during video-assisted thoracic surgery (VATS) lobectomy. METHODS: A total of 374 patients undergoing VATS lobectomy during May 2007 and May 2012 were divided into 2 groups according to whether conversion was necessary. And their clinical data were retrospectively analyzed. RESULTS: Among them, 36 cases (9.6%) converted into thoractomy during VATS lobectomy. Their clinical profiles of age, gender and surgical type were similar...
December 23, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Pedro Esteban González, Nuria M Novoa, Gonzalo Varela
OBJECTIVES: The patient's position during an axillary thoracotomy can cause postoperative pain and decrease mobility of the ipsilateral shoulder. In this study, we assessed whether the implementation of a standardized analgesia program using transcutaneous electrical nerve stimulation (TENS) decreases local pain and improves ipsilateral shoulder mobility. METHOD: Randomized, single-blind, single-center clinical trial of 50 patients who had undergone anatomical lung resection via axillary muscle-sparing thoracotomy...
December 2015: Archivos de Bronconeumología
Amy J Hoffman, Ruth Ann Brintnall, Alexander von Eye, Lee W Jones, Gordon Alderink, Lawrence H Patzelt, Jean K Brown
OBJECTIVE: The objective of this pilot study was to describe the effects of a 16-week home-based rehabilitative exercise program on cancer-related fatigue (CRF), other symptoms, functional status, and quality of life (QOL) for patients with non-small cell lung cancer (NSCLC) after thoracotomy starting within days after hospital discharge and continuing through the initiation and completion of chemotherapy. MATERIALS AND METHODS: Five patients with NSCLC completed the Brief Fatigue Inventory (measuring CRF severity) and the MD Anderson Symptom Inventory (measuring symptom severity) before and after thoractomy, and at the end of each week of the 16-week exercise program...
2014: OncoTargets and Therapy
Qiang Fu, Feng Zhao, Weidong Mi, Hong Zhang
The purpose of this study was to investigate the ability of stroke volume variation (SVV) to predict fluid responsiveness in patients undergoing pulmonary lobectomy with one lung ventilation (OLV). Thirty patients intubated with double-lumen tube were scheduled for a pulmonary lobectomy requiring OLV for at least 1 hour under general anesthesia. Hemodynamic variables including heart rate, mean arterial pressure, cardiac index (CI), stroke volume index (SVI), central venous pressure (CVP) and SVV were measured before and after volume expansion (VE) (8 mL/kg of 6% hydroxyethyl starch)...
February 2014: Bioscience Trends
Carlos A Rombolá, Marta Genovés Crespo, Pedro J Tárraga López, María Dolores García Jiménez, Antonio F Honguero Martínez, Pablo León Atance, Claudia R Rodríguez Ortega, Ana Triviño Ramírez, José Antonio Rodríguez Montes
Diaphragmatic plication is the most accepted treatment for symptomatic diaphragmatic hernia in adults. The fact that this pathology is infrequent and this procedure not been widespread means that this is an exceptional technique in our field. To estimate its use in the literature, we carried out a review in English and Spanish, to which we added our series. We found only six series that contribute 59 video-assisted mini-thoractomy for diaphragmatic plications in adults, and none in Spanish. Our series will be the second largest with 18 cases...
August 2014: Cirugía Española
Meng Jiang, Lin Wang, Hai-He Jiang
OBJECTIVE: To explore the role of spinal MAPK-ERK signal pathway in myocardial ischemia-reperfusion (I/R) injury. METHODS: Sixty male Sprague-Dawley(SD) rats (80-100 g) were randomly divided into 3 groups: sham (n=10), PD98059 (n=25) and I/R groups (n=25). Three days after successful intrathecal implantation, 5 μg DMSO was injected intrathecally into the sham group, and then the left coronary arteries were separated without being tied. Rats in the I/R and PD98059 groups were injected with 5 μL DMSO and PD98059 (5 μg) 30 minutes before thoractomy respectively...
May 2013: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
Sameh Ibrahim Sersar, Mohammed Adel Alanwar
INTRODUCTION AND AIM: Emergency thoracotomy is performed either immediately at the scene of injury, in the emergency department or in the operating room. It aims to evacuate the pericardial tamponade, control the haemorrhage, to ease the open cardiac massage and to cross-clamp the descending thoracic aorta to redistribute blood flow and maybe to limit sub-diaphragmatic haemorrhage, bleeding and iatrogenic injury are the common risk factors. We aimed to review our experience in the field of emergency thoracotomies, identify the predictors of death, analyze the early results, detect the risk factors and asses the mortalities and their risk factors...
January 2013: Journal of Emergencies, Trauma, and Shock
Xu-chen Ma, Song-lei Ou, Zhi-tai Zhang, Yan-sheng Hu, Fei-qiang Song
OBJECTIVE: To analyze the outcomes of lung resection and off-pump coronary artery bypass grafting (OPCAB) synchronously for the patients with lung tumor and concurrent coronary heart disease. METHODS: Twenty-two patients with lung tumor and concurrent coronary heart disease underwent combined surgical interventions between January 2003 and December 2011. They included 20 males and 2 females with a mean age of (65 ± 4) years. The TNM stage of lung cancer was predominantly at stages I and II...
November 27, 2012: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Xuchen Ma, Zhitai Zhang, Yansheng Hu, Feiqiang Song, Shaoyan Zhang, Songlei Ou
BACKGROUND: The number of patients with both lung cancer and coronary heart disease has increased for the last ten years. The aim of this study is to analyze the outcome of the combined treatment of radical surgery and off-pump coronary artery bypass grafting (OPCABG) for patients with both lung cancer and coronary heart disease. METHODS: The clinical data of 18 patients (16 males and 2 females, mean age of 66.11 years) with both lung cancer and coronary heart disease who went through combined surgical interventions between 2003 and 2012 were summarized and analyzed...
October 20, 2012: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Wei Wang, Hong-Tian Zhang, Xi-Li Yang
AIMS: To explore the expression of matrix metalloproteinase and tissue inhibitor of metalloproteinase of atrial myocardial structure of rheumatic and coronary heart disease. METHODS: Fifty patients with rheumatic heart disease (RHD) undergoing artificial mitral valve replacement surgery were selected: 20 with sinus rhythm and 30 with atrial fibrillation. Another 40 patients with coronary artery disease (CAD) undergoing coronary artery bypass surgery were selected: 22 with myocardial infarction (MI) and 18 with unstable angina...
April 2013: Journal of Cardiovascular Medicine
Gilbert Seda, Christopher M Stafford, John S Parrish, Steven P Praske, Massoud Daheshia
UNLABELLED: Lung cancer remains a major medical impediment in which early diagnosis and timely treatment are key factors in its management. This study evaluated nonsmall cell lung cancer (NSCLC) patients in a large military medical center to determine the timeliness to diagnosis and curative surgery in comparison with published guidelines. A retrospective record review of tumor registry NSCLC surgery cases at Navy Medical Center San Diego (NMCSD) from 2004 to 2009 was conducted. Of the 84 patients, 49% were women, the median age was 63, 58% were Caucasian, and 71% represented ex- or active smokers...
June 2012: Military Medicine
Ivan Marjanović, Miodrag Jevtić, Sidor Misović, Momir Sarac
INTRODUCTION: Thoracoabdominal aortic aneurysm (TAAA) type IV represents an aortic dilatation from the level of the diaphragmatic hiatus to the iliac arteries branches, including visceral branches of the aorta. In the traditional procedure of TAAA type IV repair, the body is opened using thoractomy and laparotomy in order to provide adequate exposure of the descending thoracic and abdominal aorta for safe aortic reconstruction. CASE REPORT: We reported a 71-year-old man with elective reconstruction of the TAAA type IV performed by transabdominal approach...
January 2012: Vojnosanitetski Pregled. Military-medical and Pharmaceutical Review
Hany Elsayed
Paravertebral block catheters are a recognized method of regional pain control after a thoractomy. We describe a technique of insertion with the belief that it provides a superior positioning of the paravertebral (extra-pleural) catheter resulting in a better distribution of the local anaesthetic and better pain control.
May 2012: Interactive Cardiovascular and Thoracic Surgery
Raja M Flores, Ugonna Ihekweazu, Joseph Dycoco, Nabil P Rizk, Valerie W Rusch, Manjit S Bains, Robert J Downey, David Finley, Prasad Adusumilli, Inderpal Sarkaria, James Huang, Bernard Park
OBJECTIVE: Large case series have demonstrated that video-assisted thoracoscopic surgery (VATS) lobectomy is feasible and safe. However, catastrophic intraoperative complications during VATS lobectomy requiring thoracotomy can be overlooked and are not reported in the current literature. We reviewed our experience to determine the frequency, management, and outcome of these complications. METHODS: A systematic review of a prospective database was performed after institutional review board approval...
December 2011: Journal of Thoracic and Cardiovascular Surgery
Daniel M Sciubba, Ziya L Gokaslan, James H Black, Oliver Simmons, Ian Suk, Timothy F Witham, Ali Bydon, Jean-Paul Wolinsky
BACKGROUND AND IMPORTANCE: Primary tumors of the spine are considered for en bloc resection to improve local control and even obtain cure. Anatomic restrictions often prohibit extensive resections with negative margins that are safe and feasible. We report the first case involving a patient with a large chordoma of the thoracic spine who underwent a successful 5-level spondylectomy with bilateral chest wall resection for en bloc resection without neurologic compromise. CLINICAL PRESENTATION: A 26-year-old woman with a chest mass was found to have a T1-5 chordoma via a percutaneous biopsy...
December 2011: Neurosurgery
Zhenrong Zhang, Deruo Liu, Yongqing Guo, Bin Shi, Yanchu Tian, Zhiyi Song, Haitao Zhang, Zhaoyang Liang
BACKGROUND AND OBJECTIVE: VATS-lobectomy has been used as regular surgical procedure clinically for non-small cell lung cancer. The aim of this study is to evaluate the surgical emergencies during VATS and the related factors postoperatively. METHODS: Clinical data were reviewed for patients who were performed with pulmonary related surgery between January 2006 and July 2008 in our department. RESULTS: 248 (117 CVATS and 131 AVATS) VATS lobectomy were performed, including 13 cases that were transferred into AVATS or OPEN...
June 2011: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
Li-Wei Lo, Chuen-Wang Chiou, Yenn-Jiang Lin, Shih-Huang Lee, Shih-Ann Chen
BACKGROUND: It has been demonstrated that intrinsic cardiac autonomic activation of ganglionated plexi (GPs) exhibits a frequency gradient from the center to the periphery with limited mapping. OBJECTIVE: We aimed to use a global mapping tool (Ensite Array) to identify the frequency distribution and clarify the interaction between the extrinsic/intrinsic autonomic systems. METHODS: A mid sternal thoractomy was performed in anesthetized dogs...
September 2011: Journal of Cardiovascular Electrophysiology
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