Shephal K Doshi, Saibal Kar, Ashish Sadhu, Rodney Horton, Jose Osorio, Christopher Ellis, James Stone, Manish Shah, Srinivas R Dukkipati, Stuart Adler, Devi G Nair, Jamie Kim, Oussama Wazni, Matthew J Price, David R Holmes, Robert Shipley, Thomas Christen, Dominic J Allocco, Vivek Y Reddy
Background The PINNACLE FLX (Protection Against Embolism for Non-valvular AF [Atrial Fibrillation] Patients: Investigational Device Evaluation of the Watchman FLX LAA [Left Atrial Appendage] Closure Technology) trial evaluated the safety and efficacy of a next-generation left atrial appendage closure device (WATCHMAN FLX; Boston Scientific, Marlborough, MA). At 1 year, the study met the primary end points of safety and anatomical efficacy/appendage closure. This final report of the PINNACLE FLX trial includes the prespecified secondary end point of ischemic stroke or systemic embolism at 2 years, also making it the first report of 2-year outcomes with this next-generation left atrial appendage closure device...
February 21, 2023: Journal of the American Heart Association