keyword
MENU ▼
Read by QxMD icon Read
search

Candida glabrata

keyword
https://www.readbyqxmd.com/read/28802173/fungicidal-activity-of-copper-sputtered-flexible-surfaces-under-dark-and-actinic-light-against-azole-resistant-candida-albicans-and-candida-glabrata
#1
Myriam K S Ballo, Sami Rtimi, John Kiwi, César Pulgarin, José M Entenza, Alain Bizzini
Candida spp. are able to survive on hospital surfaces and causes healthcare-associated infections (HCAIs). Since surface cleaning and disinfecting interventions are not totally effective to eliminate Candida spp., new approaches should be devised. Copper (Cu) has widely recognized antifungal activity and the use of Cu-sputtered surfaces has recently been proposed to curb the spread of HCAIs. Moreover, the activity of Cu under the action of actinic light remains underexplored. We investigated the antifungal activity of Cu-sputtered polyester surfaces (Cu-PES) against azole-resistant Candida albicans and Candida glabrata under dark and low intensity visible light irradiation (4...
July 29, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28793937/effectiveness-of-disinfectants-against-candida-auris-and-other-candida-species
#2
Jennifer L Cadnum, Aaron A Shaikh, Christina T Piedrahita, Thriveen Sankar, Annette L Jencson, Emily L Larkin, Mahmoud A Ghannoum, Curtis J Donskey
Contaminated surfaces are a suspected source for dissemination of the globally emerging pathogen Candida auris. In laboratory testing, sporicidal and improved hydrogen peroxide disinfectants were highly effective against C. auris, C. glabrata, and C. albicans. The widely used quaternary ammonium disinfectants exhibited relatively poor activity against all of the Candida species. Infect Control Hosp Epidemiol 2017;1-4.
August 10, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28774698/the-global-problem-of-antifungal-resistance-prevalence-mechanisms-and-management
#3
REVIEW
David S Perlin, Riina Rautemaa-Richardson, Ana Alastruey-Izquierdo
All serious fungal infections need appropriate antifungal therapy for successful patient outcome. Only a few classes of antifungal drugs are available, so the emergence of resistance to single drug classes and now multidrug resistance greatly hampers patient management. Azole resistance among Candida and Aspergillus species is one of the greatest challenges to clinical success, followed by echinocandin and multidrug resistance among some Candida species, especially Candida glabrata. The spread of agriculturally derived azole-resistant Aspergillus fumigatus and emerging threats such as multidrug resistant Candida auris are also alarming...
July 31, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28770873/prevalence-and-antifungal-susceptibility-of-candida-species-in-a-tertiary-care-hospital-in-islamabad-pakistan
#4
Umber Tasneem, Maryam Tahir Siddiqui, Rani Faryal, Aamer Ali Shah
OBJECTIVE: To determine the prevalence and antifungal susceptibility pattern of Candida species. METHODS: This prospective, cross-sectional study was conducted at the Quaid-e-Azam International Hospital, Islamabad, Pakistan, from January 2014 to February 2015, and comprised different clinical samples which were analysed for various types of microbial infections. Species differentiation was confirmed by biochemical and molecular methods. Antifungal susceptibility against amphotericin B, fluconazole and voriconazole was determined by Clinical and Laboratory Standards Institute M44-A disk diffusion method...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28768479/evaluation-of-candidemia-in-epidemiology-and-risk-factors-among-cancer-patients-in-a-cancer-center-of-china-an-8-year-case-control-study
#5
Ding Li, Rui Xia, Qing Zhang, Changsen Bai, Zheng Li, Peng Zhang
BACKGROUND: Candidemia is the worldwide life-threaten disease, especially in cancer patients. This study was aimed to identify and evaluate the risk factors of candidemia in cancer patients, which will prompt the improvement on current therapeutic strategies and prognosis. METHODS: A retrospective, case-control study was conducted from inpatients of Tianjin Medical University Cancer Institute and Hospital, during 2006 to 2013. Analyses were performed between cancer patients with candidemia as study case, and patients with bacterial bloodstream infections as control...
August 3, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28762125/progress-in-definition-prevention-and-treatment-of-fungal-infections-in-cystic-fibrosis
#6
REVIEW
Carsten Schwarz, Dominik Hartl, Olaf Eickmeier, Andreas Hector, Christian Benden, Isabelle Durieu, Amparo Sole, Silvia Gartner, Carlos E Milla, Peter James Barry
Cystic fibrosis (CF) is a chronic lethal multi-system condition; however, most of the morbidity and mortality is dependent on the status of the respiratory system. Progressive respiratory decline is mediated by chronic infection and inflammation, punctuated by important acute events known as pulmonary exacerbations which can lead to accelerated decline. The main bacterial species causing infections include Pseudomonas aeruginosa, Staphylococcus aureus, Haemophilus influenzae and Achromobacter xylosoxidans. In addition to bacteria, fungi are detected in a significant number of patients...
July 31, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28758337/changes-in-the-distribution-of-colonising-and-infecting-candida-spp-isolates-antifungal-drug-consumption-and-susceptibility-in-a-french-intensive-care-unit-a-10-year-study
#7
Milène Sasso, Claire Roger, Magali Sasso, Hélène Poujol, Saber Barbar, Jean-Yves Lefrant, Laurence Lachaud
Monitoring fungal ecology and resistance to antifungal agents within intensive care units (ICU) is essential for the management of invasive fungal infections. Therefore, a retrospective descriptive study was carried in the ICU of Nimes University Hospital, France, from 2007 to 2016. As the majority of invasive fungal infections in ICU are caused by Candida species, the study objectives were to describe Candida species distribution, to assess candidaemia incidence and to monitor the antifungal drug susceptibility of Candida isolates and the consumption of antifungal agents...
July 31, 2017: Mycoses
https://www.readbyqxmd.com/read/28748033/candida-and-porphyromonas-gingivalis-the-effect-on-wound-closure-in-vitro
#8
Thijs M Haverman, Alexa M G A Laheij, Johannes J de Soet, Jan de Lange, Frederik R Rozema
Microorganisms play a role in oral mucositis after cancer therapy. The current study explored the hypothesis that Candida spp. alone and together with Porphyromonas gingivalis cause delayed healing of oral ulcerations due to the inhibition of wound closure. An in vitro scratch assay model was used to study the influence of viable and heat-killed Candida glabrata, Candida kefyr, and Candida albicans on cell migration of oral epithelial cells. Separately, the effect of conditioned medium of Candida spp. and the effect of a mixed infection of Candida spp...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28748027/oral-candidiasis-among-african-human-immunodeficiency-virus-infected-individuals-10-years-of-systematic-review-and-meta-analysis-from-sub-saharan-africa
#9
REVIEW
Martha F Mushi, Oliver Bader, Liliane Taverne-Ghadwal, Christine Bii, Uwe Groß, Stephen E Mshana
Oral candidiasis (OC) is the most common opportunistic fungal infection among immunocompromised individuals. This systematic review and meta-analysis reports on the contribution of non-albicans Candida species in causing OC among human immunodeficiency virus (HIV)-infected individuals in sub-Saharan Africa between 2005 and 2015. Thirteen original research articles on oral Candida infection/colonization among HIV-infected African populations were reviewed. The prevalence of OC ranged from 7.6% to 75.3%. Pseudomembranous candidiasis was found to range from 12...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/28730719/anticandidal-activity-of-extracts-and-a-novel-compound-amnomopin-isolated-from-petriella-setifera
#10
Amani S Awaad, Nour K Al-Aonazi, Monerah R Al-Othman, Mohamed E Zain, Reham M El-Meligy, Nabil El-Sayed
A novel triterpenoidal compound named 'amnomopin' (3β-diglucoside-5,12-28-oic acid), which is named IUPAC as 3-O-(2' ➔ 1″diglucoside)1,2,3,4,4a,5,6,6a,6b,7,9,10,11,12,12a,12b,13,14b-octadecahydro-10-hydroxy-2,2,6a,6b,9,9,12a-heptamethylpicene-4a-carboxylic acid, was isolated from the extract Petriella setifera. The total alcoholic extract of P. setifera showed a great activity against clinically isolated Candida species, including Candida albicans, Candida dubliniensis, Candida famata, Candida glabrata, Candida inconspicua, Candida kefyr, Candida krusei, Candida norvegensis, Candida parapsilosis and Candida tropicalis...
July 20, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28730269/emergence-of-candida-glabrata-in-vulvovaginal-candidiasis-should-be-attributed-to-selective-pressure-or-virulence-ability
#11
Sandra Sayuri Nakamura-Vasconcelos, Adriana Fiorini, Pamela Delvas Zanni, Patrícia de Souza Bonfim-Mendonça, Janine Ribeiro Godoy, Adriana Araújo Almeida-Apolonio, Marcia Edilaine Lopes Consolaro, Terezinha Inez Estivalet Svidzinski
PURPOSE: Vulvovaginal candidiasis (VVC) is one of the most frequent female genital disorders and Candida glabrata is the second most common agent. Current study was aimed to study the susceptibility to antifungal agents of C. glabrata isolated from vaginal samples and some virulence attributes in order to better understand why this species is emerging as the main VVC agents. METHODS: A total of 60 C. glabrata vaginal isolates were included in this study. Firstly they were screened by susceptibility tests to antifungal agents...
July 20, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28728388/characterization-of-culturable-yeast-species-associating-with-whole-crop-corn-and-total-mixed-ration-silage
#12
Huili Wang, Wei Hao, Tingting Ning, Mingli Zheng, Chuncheng Xu
Objective: This study aims to investigate the association of yeast species with improved aerobic stability of total mixed ration (TMR) silages with prolonged ensiling, and clarify the characteristics of yeast species and their role during aerobic deterioration. Methods: Whole crop corn (WCC) silages and TMR silages formulated with WCC were ensiled for 7, 14, 28 and 56 d and used for aerobic stability test. Predominant yeast species were isolated from different periods and identified by sequencing analyses of the 26S rRNA gene D1/D2 domain...
June 26, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28727942/dectin-1-embraces-candida-glabrata
#13
Carlos Del Fresno Sánchez
No abstract text is available yet for this article.
July 20, 2017: Virulence
https://www.readbyqxmd.com/read/28720726/mitochondrial-cochaperone-mge1-is-involved-in-regulating-susceptibility-to-fluconazole-in-saccharomyces-cerevisiae-and-candida-species
#14
Liesbeth Demuyser, Erwin Swinnen, Alessandro Fiori, Beatriz Herrera-Malaver, Kevin Vestrepen, Patrick Van Dijck
MGE1 encodes a yeast chaperone involved in Fe-S cluster metabolism and protein import into the mitochondria. In this study, we identified MGE1 as a multicopy suppressor of susceptibility to the antifungal fluconazole in the model yeast Saccharomyces cerevisiae We demonstrate that this phenomenon is not exclusively dependent on the integrity of the mitochondrial DNA or on the presence of the drug efflux pump Pdr5. Instead, we show that the increased dosage of Mge1 plays a protective role by retaining increased amounts of ergosterol upon fluconazole treatment...
July 18, 2017: MBio
https://www.readbyqxmd.com/read/28710262/med15b-regulates-acid-stress-response-and-tolerance-in-candida-glabrata
#15
Yanli Qi, Hui Liu, Jiayin Yu, Xiulai Chen, Liming Liu
Candida glabrata is a promising producer of organic acids. To elucidate the physiological function of the Mediator tail subunit Med15B in the response to low pH stress, we constructed a deletion strain, med15BΔ, and overexpression strain, HTUΔ/CgMED15B Deletion of MED15B caused biomass production, glucose consumption rate, and cell viability to decrease by 28.3%, 31.7%, and 26.5%, respectively, compared with those of the parent strain (HTUΔ) at pH 2.0. Expression of lipid metabolism-related genes was significantly downregulated in the med15BΔ strain, whereas key genes of ergosterol biosynthesis showed abnormal upregulation...
July 14, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28700656/unexpected-effects-of-azole-transporter-inhibitors-on-antifungal-susceptibility-in-candida-glabrata-and-other-pathogenic-candida-species
#16
Yohsuke Nagayoshi, Taiga Miyazaki, Shintaro Shimamura, Hironobu Nakayama, Asuka Minematsu, Shunsuke Yamauchi, Takahiro Takazono, Shigeki Nakamura, Katsunori Yanagihara, Shigeru Kohno, Hiroshi Mukae, Koichi Izumikawa
The pathogenic fungus Candida glabrata is often resistant to azole antifungal agents. Drug efflux through azole transporters, such as Cdr1 and Cdr2, is a key mechanism of azole resistance and these genes are under the control of the transcription factor Pdr1. Recently, the monoamine oxidase A (MAO-A) inhibitor clorgyline was shown to inhibit the azole efflux pumps, leading to increased azole susceptibility in C. glabrata. In the present study, we have evaluated the effects of clorgyline on susceptibility of C...
2017: PloS One
https://www.readbyqxmd.com/read/28689871/cd101-a-long-acting-echinocandin-and-comparator-antifungal-agents-tested-against-a-global-collection-of-invasive-fungal-isolates-in-the-sentry-2015-antifungal-surveillance-program
#17
Michael A Pfaller, Shawn A Messer, Paul R Rhomberg, Mariana Castanheira
CD101 is a novel echinocandin with exceptional chemical stability and long-acting pharmacokinetics. The activity of CD101 and comparators was evaluated using CLSI broth microdilution methods against 713 invasive fungal isolates, including 589 Candida spp. (6 species), 14 C. neoformans, 97 A. fumigatus and 13 A. flavus species complex collected worldwide during 2015. All C. tropicalis, C. krusei and C. dubliniensis, 99.7% of C. albicans and 98.3% of C. glabrata were inhibited by ≤0.12 µg/mL of CD101, and these isolates were susceptible/wild type to other echinocandins using CLSI clinical breakpoint and epidemiological cutoff value (ECV) interpretive criteria...
July 6, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28688376/molecular-identification-and-antifungal-susceptibility-pattern-of-non-albicans-candida-species-isolated-from-vulvovaginal-candidiasis
#18
Ziba Abbasi Nejat, Shirin Farahyar, Mehraban Falahati, Mahtab Ashrafi Khozani, Aga Fateme Hosseini, Azamsadat Faiazy, Masoome Ekhtiari, Saeideh Hashemi-Hafshenjani
Background: Vulvovaginal candidiasis (VVC) is an important problem due to Candida spp. The aim of this study was molecular identification, phylogenetic analysis, and evaluation of antifungal susceptibility of non-albicans Candida isolates from VVC. Methods: Vaginal secretion samples were collected from 550 vaginitis patients at Sayyad Shirazi Medical and Educational Center of Gorgan (Golestan Province, Iran) from May to October 2015. Samples were analyzed using conventional mycological and molecular approaches...
July 9, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28684792/fungus-derived-hydroxyl-radicals-kill-hepatic-cells-by-enhancing-nuclear-transglutaminase
#19
Ronak Shrestha, Rajan Shrestha, Xian-Yang Qin, Ting-Fang Kuo, Yugo Oshima, Shun Iwatani, Ryutaro Teraoka, Keisuke Fujii, Mitsuko Hara, Mengqian Li, Azusa Takahashi-Nakaguchi, Hiroji Chibana, Jun Lu, Muyi Cai, Susumu Kajiwara, Soichi Kojima
We previously reported the importance of induced nuclear transglutaminase (TG) 2 activity, which results in hepatic cell death, in ethanol-induced liver injury. Here, we show that co-incubation of either human hepatic cells or mouse primary hepatocytes derived from wild-type but not TG2(-/-) mice with pathogenic fungi Candida albicans and C. glabrata, but not baker's yeast Saccharomyces cerevisiae, induced cell death in host cells by enhancing cellular, particularly nuclear, TG activity. Further pharmacological and genetic approaches demonstrated that this phenomenon was mediated partly by the production of reactive oxygen species (ROS) such as hydroxyl radicals, as detected by a fluorescent probe and electron spin resonance...
July 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28681025/candidemia-in-patients-with-prolonged-fever-in-kashan-iran
#20
R Razzaghi, M Momen-Heravi, M Erami, M Nazeri
BACKGROUND AND PURPOSE: Candida species are considered a common cause of fungal blood stream infections, which are associated with considerable mortality and morbidity rates, especially in the admitted and immunocompromised patients. Despite the increase in new and available antifungal agents, the emergence of resistant strains is growing. Regarding this, the aim of the present study was to assess the fungal epide-miology of candidemia and the antifungal susceptibility patterns against five current antifungal agents among the patients with prolonged fever, who were admitted to Beheshti Educational Hospital, Kashan, Iran...
September 2016: Advances in Medical Mycology (Iran)
keyword
keyword
66667
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"