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Candida glabrata

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https://www.readbyqxmd.com/read/28100311/the-evaluation-of-three-different-bottles-in-bactec-9240-automated-blood-culture-system-and-direct-identification-of-candida-species-to-shorten-the-turnaround-time-of-blood-culture
#1
Egemen Gokbolat, Yasemin Oz, Selma Metintas
Candida spp. are the most common causes of fungemia. Rapid and accurate diagnostic methods are very important for appropriate management of candidemia. At present, blood culture is the essential diagnostic test despite it has a long detection time and low sensitivity rate. We aimed to investigate the ways to shorten the turnaround time from blood culture collection to final identification in candidemia. Sixty clinical bloodstream isolates of Candida were included and the Plus Aerobic/F, Peds Plus/F and Mycosis IC/F (MICF) bottles were used with BACTEC 9240 blood culture instrument...
January 16, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28091850/repeated-applications-of-photodynamic-therapy-on-candida-glabrata-biofilms-formed-in-acrylic-resin-polymerized
#2
Lírian Silva de Figueiredo Freitas, Rodnei Dennis Rossoni, Antonio Olavo Cardoso Jorge, Juliana Campos Junqueira
Previous studies have been suggested that photodynamic therapy (PDT) can be used as an adjuvant treatment for denture stomatitis. In this study, we evaluated the effects of multiple sessions of PDT on Candida glabrata biofilms in specimens of polymerized acrylic resin formed after 5 days. Subsequently, four applications of PDT were performed on biofilms in 24-h intervals (days 6-9). Also, we evaluated two types of PDT, including application of laser and methylene blue or light-emitting diode (LED) and erythrosine...
January 14, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28088767/pharmacokinetic-study-of-anidulafungin-in-icu-patients-with-intra-abdominal-candidiasis
#3
H Dupont, L Massias, B Jung, N Ammenouche, P Montravers
BACKGROUND: Only limited pharmacokinetic data are available for anidulafungin in ICU patients, especially in patients treated for severe intra-abdominal infection (IAI). METHODS: This was a prospective multicentre observational study in ICU patients with suspected yeast IAI. All patients received an intravenous loading dose of 200 mg of anidulafungin, followed by 100 mg/day. Thirteen blood samples were drawn between day 1 and day 5 for pharmacokinetic analysis...
January 14, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28071858/synthesis-and-biological-evaluation-of-novel-2-aminonicotinamide-derivatives-as-antifungal-agents
#4
Tingjunhong Ni, Ran Li, Fei Xie, Jing Zhao, Xin Huang, Maomao An, Chengxu Zang, Zhan Cai, Dazhi Zhang, Yuanying Jiang
Based on the structures of the reported compounds G884 [N-(3-(pentan-2-yloxy)phenyl)nicotinamide], E1210 [3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine], and 10 b [2-amino-N-((5-(3-fluorophenoxy)thiophen-2-yl)methyl)nicotinamide], which inhibit the biosynthesis of glycosylphosphatidylinositol (GPI)-anchored proteins in fungi, a series of novel 2-aminonicotinamide derivatives were designed, synthesized, and evaluated for in vitro antifungal activity. Most of these compounds were found to exhibit potent in vitro antifungal activity against Candida albicans, with MIC80 values ranging from 0...
January 10, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28069658/scy-078-is-fungicidal-in-time-kill-studies-against-candida-species
#5
Bernard Scorneaux, David Angulo, Katyna Borroto-Esoda, Mahmoud Ghannoum, Michael Peel, Stephen Wring
SCY-078 is an orally bioavailable ß-1,3-glucan synthesis inhibitor (GSI) and the first-in-class of structurally novel triterpine antifungals in clinical development for treating candidemia and invasive candidiasis. In vitro susceptibility by broth micro-dilution, antifungal carry-over, and time-kill dynamics were determined for 3 reference (ATCC) strains (C. albicans 90028, C. parapsilosis 90018, and C. tropicalis 750), a Quality Control (QC) strain (C krusei 6258), and 4 other strains (C. albicans MYA-2732, 64124, 76485 and C...
January 9, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28068213/utilization-of-size-polymorphism-in-its1-and-its2-regions-for-identification-of-pathogenic-yeast-species
#6
Hossein Khodadadi, Ladan Karimi, Niloufar Jalali-Zand, Hassan Adin, Hossein Mirhendi
Despite the existence of a variety of available yeast identification strategies, easier and more cost-effective methods are required for routine use in clinical laboratories. The internal transcribed spacer (ITS) regions of fungal rRNA genes exhibit variable sizes depending on the yeast species. In the present study, fragment size polymorphism (FSP) analysis of the ITS1 and ITS2 regions for identification of the clinically most important yeast species was assessed. The ITS1 and ITS2 regions of 190 strains, including isolates of 31 standard strains and 159 clinical isolates, were separately PCR-amplified with two primer sets: ITS1-ITS2 and ITS3-ITS4...
January 9, 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28065893/pan-azole-resistant-candida-tropicalis-carrying-homozygous-erg11-mutations-at-position-k143r-a-new-emerging-superbug
#7
Mariana I D S Xisto, Rita D F Caramalho, Débora A S Rocha, Antonio Ferreira-Pereira, Bettina Sartori, Eliana Barreto-Bergter, Maria L Junqueira, Cornelia Lass-Flörl, Michaela Lackner
OBJECTIVES: Candidaemia is a public health problem mainly in hospitalized individuals worldwide. In Brazil, Candida albicans is the most prevalent species that causes candidaemia, followed by Candida tropicalis and Candida parapsilosis Few data on the abundance of antifungal resistance are available for Latin America. METHODS: We analysed the frequency of azole and echinocandin resistance in Candida isolates (n = 75) collected between 2012 and 2014 at the University Hospital of Federal University of Juiz de Fora (Brazil)...
January 8, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28052349/chemical-composition-and-antifungal-activity-of-carica-papaya-linn-seeds-essential-oil-against-candida-spp
#8
Xiaowen He, Yinzheng Ma, Guohui Yi, Jinyan Wu, Limin Zhou, Hong Guo
In recent years, the incidence of clinical yeast infections has increased dramatically. Due to the extensive use of broad-spectrum antifungal agents, there has been a notable increase in drug resistance among infections yeast species. As one of the most popular natural antimicrobial agents, essential oils (EOs) have attracted a lot of attention from the scientific community. The aim of this study was to analyze the chemical composition and examine the antifungal activity of the EO extracted from the seeds of Carica papaya Linn...
January 4, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/28050365/caspofungin-mic-distribution-amongst-commonly-isolated-candida-species-in-a-tertiary-care-centre-an-indian-experience
#9
Shashir Wanjare, Rajarshi Gupta, Preeti Mehta
INTRODUCTION: Emergence of Candida species resistant to Amphotericin B and triazole has led to use of echinocandins, mostly caspofungin in the management of invasive candidiasis. There are some published reports of caspofungin resistance in Candida species yet no studies on caspofungin susceptibility pattern of Candida species exist in Indian setup. AIM: To carry out the antifungal susceptibility of Candida isolates against caspofungin. MATERIALS AND METHODS: In a retrospective study at a tertiary care teaching hospital, 60 preserved Candida isolates from inpatients of invasive candidiasis obtained over a period of 6 months from January 2015 to June 2015 were subjected to antifungal susceptibility to caspofungin and the Minimum Inhibitory Concentrations (MICs) of Candida species to caspofungin were determined by Epsilometer test (E-test)...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28038478/activity-of-the-aqueous-extract-of-schinus-terebinthifolius-raddi-on-strains-of-the-candida-genus
#10
Kátia Andrea de Menezes Torres, Sônia Maria Rolim Rosa Lima, Suely Mitoi Ykko Ueda
Objectives To evaluate the antifungal susceptibility profile of the aqueous extract of the bark of Schinus terebinthifolius Raddi against the strains of the genus Candida. Methods By using the disk diffusion method, 50 samples of the genus Candida (Candida albicans; Candida krusei; Candida glabrata; and Candida tropicalis), isolated from patients receiving treatment at Hospital Santa Casa de Misericórdia de São Paulo, and 1 American Type Culture Collection (ATCC) sample of each species were tested against: the isolated aqueous extract of the bark of Schinus terebinthifolius Raddi, isolated nystatin, and the association of nystatin and the aqueous extract of Schinus terebinthifolius Raddi...
December 30, 2016: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/28028508/effects-of-aspirin-as-an-anti-inflammatory-drug-on-azole-resistant-candida-glabrata-in-vitro
#11
Sanaz Goodarzi, Seyyed Amin Ayatollahi Mousavi, Somayeh Sharifynia, Azar Berahmeh, Sassan Rezaie
No abstract text is available yet for this article.
November 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28024529/fungicidal-effect-of-thymoquinone-involves-generation-of-oxidative-stress-in-candida-glabrata
#12
Hala Almshawit, Ian Macreadie
The antifungal effect of thymoquinone, a component of black seed essential oil, has been studied on different types of fungi. Its mechanism of action as an antifungal has not been described yet. This study demonstrates the fungicidal effect of thymoquinone on different Candida species with particular emphasis on C. glabrata planktonic cells and biofilms. Since cell death was induced via the generation of oxidative stress as evidenced by the abrogation of thymoquinone toxicity in cells incubated with antioxidants, a part of thymoquinone's mechanism of action includes a direct involvement as a pro-oxidant...
January 2017: Microbiological Research
https://www.readbyqxmd.com/read/28018323/genetic-drivers-of-multidrug-resistance-in-candida-glabrata
#13
Kelley R Healey, Cristina Jimenez Ortigosa, Erika Shor, David S Perlin
Both the incidence of invasive fungal infections and rates of multidrug resistance associated with fungal pathogen Candida glabrata have increased in recent years. In this perspective, we will discuss the mechanisms underlying the capacity of C. glabrata to rapidly develop resistance to multiple drug classes, including triazoles and echinocandins. We will focus on the extensive genetic diversity among clinical isolates of C. glabrata, which likely enables this yeast to survive multiple stressors, such as immune pressure and antifungal exposure...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28011958/cationic-porphyrin-mediated-photodynamic-inactivation-of-candida-biofilms-and-the-effect-of-miconazole
#14
A Davies, S Gebremedhin, M Yee, R J Padilla, N Duzgunes, K Konopka, B Dorocka-Bobkowska
The formation of biofilms by Candida and the increasing resistance of Candida species to antifungals contribute to the high recurrence rates of denture stomatitis. This increase has stimulated an interest in antimicrobial photodynamic therapy (aPDT) as an alternative treatment. We examined the photoactivity of the porphyrin-based photosensitizer, TMP-1363, against biofilms of C. albicans, C. glabrata, C. tropicalis and C. parapsilosis, and the effect of the combined use of miconazole and aPDT. Biofilms of three American Type Culture Collection (ATCC) strains and four clinical isolates developed on poly(methyl methacrylate) (PMMA) disks, were incubated with miconazole, followed by treatment with TMP-1363 for 30 min at 37°C...
October 2016: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/28004790/new-formyl-phloroglucinol-meroterpenoids-from-the-leaves-of-eucalyptus-robusta
#15
Zhi-Chun Shang, Ming-Hua Yang, Rui-Huan Liu, Xiao-Bing Wang, Ling-Yi Kong
Seven new formyl phloroglucinol meroterpenoids (FPMs), namely eucalrobusones J-P (1-7), as well as three known ones (8-10) were isolated from the leaves of Eucalyptus robusta. Their structures were elucidated by spectroscopic data analysis, and their absolute configurations were determined by applications of the Snatzke's helicity rule and the electron circular dichroism (ECD) calculation. These FPMs are diverse in coupling patterns between phloroglucinol and sesquiterpenoid units, forming novel polycyclic ring systems...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28000514/antimicrobial-and-antioxidant-activities-of-a-new-metabolite-from-quercus-incana
#16
Farah Gul, Khalid Mohammed Khan, Achyut Adhikari, Salman Zafar, Muhammad Akram, Haroon Khan, Muhammad Saeed
Phytochemical investigations of Quercus incana led to the isolation of a new catechin derivative quercuschin (1), along with six known compounds: quercetin (2), methyl gallate (3), gallic acid (4), betulinic acid (5), (Z)-9-octadecenoic acid methyl ester (6) and β-sitosterol glucoside (7) from the ethyl acetate fraction of methanolic extract of the bark. Compound 1 was screened for its antibacterial, antifungal and antioxidant potential. Antibacterial and antifungal activities of the compound were tested against different bacterial and fungal strains, employing the agar well diffusion methods...
December 21, 2016: Natural Product Research
https://www.readbyqxmd.com/read/27995055/recurrent-episodes-of-candidemia-due-to-candida-glabrata-candida-tropicalis-and-candida-albicans-with-acquired-echinocandin-resistance
#17
Marine Grosset, Marie Desnos-Ollivier, Cendrine Godet, Catherine Kauffmann-Lacroix, France Cazenave-Roblot
Mixed fungal infection and acquired echinocandin resistance of Candida spp. remain infrequent. In this study we have reported the case of a patient hospitalized for tuberculosis who experienced multiple infections due to three common Candida species (C. albicans, C. glabrata, C. tropicalis). Furthermore, consecutive isolates from blood cultures and heart valve were found resistant to azoles (C. tropicalis) and to echinocandin with either novel (C. tropicalis) or previously described (C. albicans) missense mutations in the Fks gene...
December 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/27988224/photoinactivation-of-single-and-mixed-biofilms-of-candida-albicans-and-non-albicans-candida-species-using-phorodithazine-%C3%A2
#18
Juliana Cabrini Carmello, Fernanda Alves, Ewerton Garcia de Oliveira Mima, Janaina Habib Jorge, Vanderlei Salvador Bagnato, Ana Cláudia Pavarina
This study evaluated the effectiveness of antimicrobial photodynamic therapy (aPDT) mediated by Photodithazine(®) (PDZ) formulated in hydrogel, in the inactivation of mono and duo-species biofilms of Candida albicans, Candida glabrata and Candida tropicalis. Standardized suspensions of each strain were prepared and after biofilm formation, mono-species were treated with 150 and 175mg/L of PDZ for 20minutes (pre-irradiation time), and exposed to LED light at a dose of 37.5J/cm(2) (660nm). The duo-species biofilms (C...
December 14, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27960572/a-sensitive-and-a-rapid-multiplex-polymerase-chain-reaction-for-the-identification-of-candida-species-in-concentrated-oral-rinse-specimens-in-patients-with-diabetes
#19
Asanga Sampath, Manjula Weerasekera, Chinthika Gunasekara, Ayomi Dilhari, Uditha Bulugahapitiya, Neluka Fernando
OBJECTIVES: Oral candidiasis is being frequently recognized in patients with diabetes, and is associated with multiple pathogens including Candida albicans, Candida parapsilosis, Candida glabrata and Candida tropicalis. The aim of this study was to evaluate a usefulness of a Multiplex Polymerase Chain Reaction as a rapid diagnostic tool for identification of four oral Candida pathogens in patients with diabetes. MATERIALS AND METHODS: A multiplex PCR was optimized to identify four Candida species in concentrated oral rinse samples...
March 2017: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27959780/in-vitro-antifungal-susceptibilities-of-candida-species-to-liposomal-amphotericin-b-determined-using-clsi-broth-microdilution-and-amphotericin-b-deoxycholate-measured-using-the-e-test
#20
Lovero Grazia, De Giglio Osvalda, Rutigliano Serafina, Diella Giusy, Caggiano Giuseppina, Maria Teresa Montagna
The antifungal susceptibilities of 598 isolates of Candida spp. (bloodstream, other sterile sites) to liposomal amphotericin B (L-AmB) versus amphotericin B (AmB) were determined. Minimal inhibitory concentrations (MICs) were calculated using the Clinical and Laboratory Standards Institute broth microdilution (BMD; M27-A3) method for L-AmB and the E-test method for AmB. The MIC50/MIC90 (µg ml-1) values for L-AmB BMD and AmB E-test were 0.25/1 and 0.19/0.5, respectively. The overall essential agreement (± 2 dilutions) was 91...
December 13, 2016: Journal of Medical Microbiology
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