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Candida glabrata

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https://www.readbyqxmd.com/read/29784839/clonal-spread-in-candida-glabrata-bloodstream-isolates-and-fluconazole-resistance-affected-by-prolonged-exposure-a-12-year-single-center-study-in-belgium
#1
Berdieke Goemaere, Katrien Lagrou, Isabel Spriet, Marijke Hendrickx, Pierre Becker
Candida glabrata is a major cause of candidemia in immunocompromised patients and is characterized by a high-level of fluconazole resistance. In the present study, acquisition of antifungal resistance and potential clonal spread of C. glabrata were explored at a single center over a 12-year period by analyzing 187 independent clinical C. glabrata bloodstream isolates. One strain was found to be micafungin resistant due to a mutation in the FKS2 gene. Fluconazole resistance remained stable throughout the period and was observed in 20 (10...
May 21, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29783771/adhesins-in-candida-glabrata
#2
REVIEW
Bea Timmermans, Alejandro De Las Peñas, Irene Castaño, Patrick Van Dijck
The human fungal pathogen Candida glabrata is causing more and more problems in hospitals, as this species shows an intrinsic antifungal drug resistance or rapidly becomes resistant when challenged with antifungals. C. glabrata only grows in the yeast form, so it is lacking a yeast-to-hyphae switch, which is one of the main virulence factors of C. albicans . An important virulence factor of C. glabrata is its capacity to strongly adhere to many different substrates. To achieve this, C. glabrata expresses a large number of adhesin-encoding genes and genome comparisons with closely related species, including the non-pathogenic S...
May 20, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29782688/oral-yeast-colonization-in-patients-with-primary-and-secondary-sj%C3%A3-gren-s-syndrome
#3
Clarissa Castro Galvão Medeiros, Luiz Gustavo Dos Anjos Borges, Karen Cherubini, Fernanda Gonçalves Salum, Renata Medina da Silva, Maria Antonia Zancanaro de Figueiredo
OBJECTIVE: The study aimed to investigate the pattern of oral yeast colonization of Sjögren's syndrome patients and its correlation to salivary flow rates, age and time of the disease progression. MATERIALS AND METHODS: Saliva and swab specimens were obtained from 45 patients (primary Sjögren's syndrome= 15/ secondary Sjögren's syndrome= 15/ healthy controls= 15). Yeast species were identified using culture method through chromogenic medium followed by polymerase chain reaction and Sanger sequencing...
May 21, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29778633/comparative-analysis-of-proteinase-phospholipase-hydrophobicity-and-biofilm-forming-ability-in-candida-species-isolated-from-clinical-specimens
#4
S Dabiri, M Shams-Ghahfarokhi, M Razzaghi-Abyaneh
Candida species are the commensal organisms of human and animal mucosa that cause a wide range of debilitating diseases in immunocompromised patients and other susceptible individuals. The present study aimed to investigate the ability of clinical isolates of various Candida species to produce proteinase and phospholipase, hydrophobicity and biofilm forming ability that assumed to have a vital role in Candida pathogenicity. Eighty-four Candida strains belonged to Candida albicans (44.1%), C. glabrata (5.9%), C...
May 16, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29776932/-cg-med3-affects-cell-size-and-budding-index-to-coordinate-candida-glabrata-cell-growth
#5
Hui Liu, Lulin Kong, Yanli Qi, Xiulai Chen, Liming Liu
Candida glabrata is a promising microorganism for the production of organic acids. Here, we report deletion and quantitative expression approaches to elucidate the role of Cg Med3AB, a subunit of the mediator transcriptional co-activator, in regulating cell growth. Deletion of Cg Med3AB caused an 8.6% decrease in final biomass based on growth curve plots and 10.5% lower cell viability. Based on transcriptomics data, the reason for this growth defect was attributable to changes in expression of genes involved in pyruvate and acetyl-CoA-related metabolism in the Cgmed3abΔ strain...
May 18, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29775686/the-comparative-efficacy-of-antiseptics-against-candida-auris-biofilms
#6
Ryan Kean, Emily McKloud, Eleanor M Townsend, Leighann Sherry, Christopher Delaney, Brian L Jones, Craig Williams, Gordon Ramage
Candida auris has emerged as a significant clinical entity due to its ability to cause outbreaks within the healthcare setting. A key feature of its nosocomial lifestyle is its ability to transfer between patients, yet little is known about the mechanisms behind this. A panel of C. auris clinical isolates was screened for their planktonic and sessile susceptibilities to skin disinfection challenge using povidone iodine, chlorhexidine and hydrogen peroxide. C. auris biofilms displayed increased tolerance to these strategies compared to planktonic cells...
May 15, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29762861/pharmacokinetic-pharmacodynamic-analysis-of-isavuconazole-against-aspergillus-spp-and-candida-spp-in-healthy-subjects-and-patients-with-hepatic-or-renal-impairment-by-monte-carlo-simulation
#7
Xiaowei Zheng, Gaoqi Xu, Liqin Zhu, Luo Fang, Yiwen Zhang, Haiying Ding, Yinghui Tong, Jiao Sun, Ping Huang
The aim of this pharmacokinetic/pharmacodynamic (PK/PD) study is to evaluate the efficacy of various isavuconazole dosing regimens for healthy individuals and patients with hepatic or renal impairment against Aspergillus spp. and Candida spp. Monte Carlo simulations were conducted using pharmacokinetic (PK) parameters and pharmacodynamics (PD) data to determine the probabilities of target attainment and cumulative fractions of response in terms of area under the concentration curve/minimum inhibition concentration (AUC/MIC) targets of isavuconazole...
May 15, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29753529/candidemia-in-the-intensive-care-unit-a-12-year-retrospective-cohort-study-in-reunion-island
#8
G Hoarau, S Picot, J Lemant, J Peytral, P Poubeau, P Zunic, C Mohr, X Coueffe, P Gerardin, E Antok
OBJECTIVES: We aimed to describe the epidemiology of Candida bloodstream infection in an intensive care unit (ICU) in Reunion Island. METHODS: We performed a retrospective cohort study and evaluated 63 candidemia episodes, which occurred between January 2004 and December 2015 in the ICU of a University Hospital in St-Pierre. RESULTS: The incidence rate of candidemia in the ICU was estimated at 7.6%. Candida albicans was the most common yeast pathogen species recovered (54%), followed by Candida glabrata (17%), Candida tropicalis (12%) and Candida parapsilosis (10%)...
May 9, 2018: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/29749387/invasive-candidiasis
#9
REVIEW
Peter G Pappas, Michail S Lionakis, Maiken Cavling Arendrup, Luis Ostrosky-Zeichner, Bart Jan Kullberg
Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp.; the most common species is Candida albicans, but the prevalence of these organisms varies considerably depending on geographical location. The spectrum of disease of invasive candidiasis ranges from minimally symptomatic candidaemia to fulminant sepsis with an associated mortality exceeding 70%. Candida spp. are common commensal organisms in the skin and gut microbiota, and disruptions in the cutaneous and gastrointestinal barriers (for example, owing to gastrointestinal perforation) promote invasive disease...
May 11, 2018: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/29748198/dynamic-changes-in-yeast-phosphatase-families-allow-for-specialization-in-phosphate-and-thiamine-starvation
#10
John V Nahas, Christine L Iosue, Noor F Shaik, Kathleen Selhorst, Bin Z He, Dennis D Wykoff
Convergent evolution is often due to selective pressures generating a similar phenotype. We observe relatively recent duplications in a spectrum of Saccharomycetaceae yeast species resulting in multiple phosphatases that are regulated by different nutrient conditions - thiamine and phosphate starvation. This specialization is both transcriptional and at the level of phosphatase substrate specificity. In Candida glabrata , loss of the ancestral phosphatase family was compensated by the co-option of a different histidine phosphatase family with three paralogs...
May 10, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29746162/antifungal-activity-of-essential-oils-against-azole-resistant-and-azole-susceptible-i-i-candida-glabrata-i-i-strains-vaginal-isolates
#11
Nadia Massa, Simone Cantamessa, Giorgia Novello, Elia Ranzato, Simona Martinotti, Matteo Pavan, Andrea Rocchetti, Graziella Berta, Elisa Gamalero, Elisa Bona
<i></i>Candida glabrata<i></i> is an opportunistic pathogen, associated with endocarditis, meningitis and disseminated disease and also with complicated vaginitis. Essential oils derived from aromatic plants are known in traditional medicine as antimicrobial agents and have antifungal properties. The aim of this work was to evaluate whether the twelve tested essential oils (tea tree, laurel, anise, basil, bergamot, lavender, mint, oregano, grapefruit, rosemary, winter savory and ginger) could have a transverse effect on <i></i>C...
May 10, 2018: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29745727/identification-of-candida-glabrata-complex-species-use-of-vitek-ms-%C3%A2-ruo-bruker-clinprotools-%C3%A2
#12
Xin Hou, Meng Xiao, Sharon Ca Chen, Fanrong Kong, He Wang, Xin Fan, Yu-Pei Zhao, Ying-Chun Xu
AIM: Distinction of species within the Candida glabrata complex (i.e., C. glabrata sensu stricto, Candida nivariensis and Candida bracarensis) is relevant for epidemiological purposes and antifungal management. MATERIALS & METHODS: Two commercial matrix-assisted laser desorption ionization-time of flight mass spectrometry systems were comprehensively evaluated for the identification of fungi within this complex. RESULTS: None of the species (C...
May 10, 2018: Future Microbiology
https://www.readbyqxmd.com/read/29743305/five-year-national-surveillance-of-invasive-candidiasis-species-distribution-and-azole-susceptibility-from-the-china-hospital-invasive-fungal-surveillance-net-chif-net-study
#13
Meng Xiao, Zi-Yong Sun, Mei Kang, Da-Wen Guo, Kang Liao, Sharon C-A Chen, Fanrong Kong, Xin Fan, Jing-Wei Cheng, Xin Hou, Meng-Lan Zhou, Ying Li, Shu-Ying Yu, Jing-Jing Huang, He Wang, Ying-Chun Xu
Data on the epidemiology of invasive candidiasis (IC) and antifungal susceptibility of Candida isolates in China are still limited. Here we report surveillance for IC from the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) Study. Sixty-five tertiary hospitals collected 8,829 Candida isolates from August 1, 2009 to July 31, 2014. Matrix-assisted laser desorption/ionization -time of flight mass spectrometry supplemented by rDNA sequencing was used to define species, and fluconazole and voriconazole susceptibilities determined by the Clinical and Laboratory Standards Institute disk diffusion method...
May 9, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29729017/risk-assessment-for-the-spread-of-candida-sp-in-dental-chair-unit-waterlines-using-molecular-techniques
#14
Wissame Mazari, Zahia Boucherit-Otmani, Imad Abdelhamid El Haci, Amine Ilahi, Kebir Boucherit
AIMS: The aim of this study was to evaluate the presence of yeasts in dental chair unit waterlines (DCUWLs) and to test their ability to form biofilms. MATERIALS AND METHODS: Eighteen dental waterlines were analysed by culture in liquid Sabouraud in order to allow the quantification and the purification of isolated yeasts from their internal surfaces. All isolates were identified by standard laboratory procedures, including CHROMagar Candida medium for orientation, commercial yeast identification system Api Candida, MALDI-TOF MS and DNA sequencing...
May 4, 2018: International Dental Journal
https://www.readbyqxmd.com/read/29712657/commonly-used-oncology-drugs-decrease-antifungal-effectiveness-against-candida-and-aspergillus-species
#15
Arielle Butts, Parker Reitler, Wenbo Ge, Jarrod R Fortwendel, Glen E Palmer
The incidence of invasive fungal infections has risen significantly in recent decades as medical interventions have become increasingly aggressive. These infections are extremely difficult to treat due to the extremely limited repertoire of systemic antifungals, the development of drug resistance, and the extent of to which the patient's immune function is compromised. Even when the appropriate antifungal therapies are administered in a timely fashion, treatment failure is common, frequently even in the absence of in vitro microbial resistance...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29712651/resistance-to-echinocandins-in-candida-can-be-detected-by-performing-the-etest-directly-on-blood-culture-samples
#16
María Ángeles Bordallo-Cardona, Laura Judith Marcos-Zambrano, Carlos Sánchez-Carrillo, Emilio Bouza, Patricia Muñoz, Pilar Escribano, Jesús Guinea
Background: We examined the rapid evaluation of susceptibility to echinocandins in Candida spp. using the Etest performed directly on positive blood cultures and anidulafungin-containing agar plates. Methods: We prospectively collected 80 positive blood cultures (Bactec™-FX system, Becton-Dickinson, Cockeysville, Maryland, USA) with echinocandin-susceptible Candida spp (n=60) and echinocandin-intermediate C. parapsilosis (n=20) from patients with candidemia. Additionally, blood culture bottles of nonfungemic/bacteremic patients were spiked with 35 echinocandin-resistant Candida spp...
April 30, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29707675/identification-of-candida-species-isolated-from-vulvovaginitis-using-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#17
Majid Alizadeh, Anna Kolecka, Teun Boekhout, Hossein Zarrinfar, Mohamad A Ghanbari Nahzag, Parisa Badiee, Ali Rezaei-Matehkolaei, Abdolmajid Fata, Somayeh Dolatabadi, Mohammad J Najafzadeh
Background and Purpose: Vulvovaginal candidiasis (VVC) is a common problem in women. The purpose of this study was to identify Candida isolates by matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) from women with vulvovaginitis that were referred to Ghaem Hospital, Mashhad, Iran. Materials and Methods: This study was conducted on 65 clinical samples isolated from women that were referred to Ghaem Hospital. All specimens were identified using phenotyping techniques, such as microscopy and culture on Sabouraud dextrose agar and corn meal agar...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29707672/evaluation-of-esterase-and-hemolysin-activities-of-different-candida-species-isolated-from-vulvovaginitis-cases-in-lorestan-province-iran
#18
Maryam Noori, Mohammad Dakhili, Asghar Sepahvand, Nader Davari
Background and Purpose: Annually affecting millions of women, vulvovaginal candidiasis (VVC) is commonly described by signs and symptoms of vulvovaginal inflammation in the presence of  Candida  species. Today, the detection of the virulence factors plays a major role in the understanding of pathogenesis of candidiasis and helps produce new anticandidial drugs to improve its treatment efficiency. Herein, we aimed to evaluate the esterase and hemolysin activities of the vaginal isolates of Candida and their relationship with the presence of VVC...
December 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29695624/new-crispr-mutagenesis-strategies-reveal-variation-in-repair-mechanisms-among-fungi
#19
Valmik K Vyas, G Guy Bushkin, Douglas A Bernstein, Matthew A Getz, Magdalena Sewastianik, M Inmaculada Barrasa, David P Bartel, Gerald R Fink
We have created new vectors for clustered regularly interspaced short palindromic repeat (CRISPR) mutagenesis in Candida albicans , Saccharomyces cerevisiae , Candida glabrata , and Naumovozyma castellii These new vectors permit a comparison of the requirements for CRISPR mutagenesis in each of these species and reveal different dependencies for repair of the Cas9 double-stranded break. Both C. albicans and S. cerevisiae rely heavily on homology-directed repair, whereas C. glabrata and N. castellii use both homology-directed and nonhomologous end-joining pathways...
April 25, 2018: MSphere
https://www.readbyqxmd.com/read/29685520/in-vitro-susceptibility-of-candida-spp-to-fluconazole-itraconazole-and-voriconazole-and-the-correlation-between-triazoles-susceptibility-results-from-a-five-year-study
#20
J Lei, J Xu, T Wang
Candida spp. is a common cause of invasive fungal disease. The aim of this study was to examine the susceptibility of Candida spp. to fluconazole, itraconazole and voriconazole and explore the correlation between triazoles susceptibility. The antifungal susceptibility in the present study was measured by ATB Fungus 3 method, and the potential relationship was examined by obtaining the correlation of measured minimal inhibitory concentrations (MICs) of Candida spp. isolates. A total of 2099 clinical isolates of Candida spp...
April 20, 2018: Journal de Mycologie Médicale
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