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Candida glabrata

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https://www.readbyqxmd.com/read/28920516/high-glucose-mediated-overexpression-of-icam-1-in-human-vaginal-epithelial-cells-increases-adhesion-of-candida-albicans
#1
Hiroshige Mikamo, Yuka Yamagishi, Hiroyuki Sugiyama, Hisato Sadakata, Shun Miyazaki, Takako Sano, Tsutomu Tomita
To investigate the involvement of ICAM-1 in the adhesion of Candida to the genitourinary epithelial cells in high glucose, we examined the adhesion of Candida albicans or Candida glabrata to human vaginal epithelial cells (VK2/E6E7) or human vulvovaginal epidermal cells (A431). These cells were cultured in 100, 500 or 3000 mg/dL glucose for three days and inoculated with Candida for 60 minutes. Followed by, adhering of Candida to the cells, which were counted. While the adhesion of Candida albicans to VK2/E6E7 significantly increased in the high glucose, A431 did not...
September 18, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28919789/antifungal-resistance-current-trends-and-future-strategies-to-combat
#2
REVIEW
Nathan P Wiederhold
Antifungal resistance represents a major clinical challenge to clinicians responsible for treating invasive fungal infections due to the limited arsenal of systemically available antifungal agents. In addition current drugs may be limited by drug-drug interactions and serious adverse effects/toxicities that prevent their prolonged use or dosage escalation. Fluconazole resistance is of particular concern in non-Candida albicans species due to the increased incidence of infections caused by these species in different geographic locations worldwide and the elevated prevalence of resistance to this commonly used azole in many institutions...
2017: Infection and Drug Resistance
https://www.readbyqxmd.com/read/28911043/multidrug-resistant-candida-epidemiology-molecular-mechanisms-and-treatment
#3
Maiken Cavling Arendrup, Thomas F Patterson
Invasive Candida infections remain an important cause of morbidity and mortality, especially in hospitalized and immunocompromised or critically ill patients. A limited number of antifungal agents from only a few drug classes are available to treat patients with these serious infections. Resistance can be either intrinsic or acquired. Resistance mechanisms are not exchanged between Candida; thus, acquired resistance either emerges in response to an antifungal selection pressure in the individual patient or, more rarely, occur due to horizontal transmission of resistant strains between patients...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28904931/isolation-of-candida-species-from-gastroesophageal-lesions-among-pediatrics-in-isfahan-iran-identification-and-antifungal-susceptibility-testing-of-clinical-isolates-by-e-test
#4
Fatemeh Salehi, Mehran Esmaeili, Rasoul Mohammadi
BACKGROUND: Candida species can become opportunistic pathogens causing local or systemic invasive infections. Gastroesophageal candidiasis may depend on the Candida colonization and local damage of the mucosal barrier. Risk factors are gastric acid suppression, diabetes mellitus, chronic debilitating states such as carcinomas, and the use of systemic antibiotics and corticosteroids. The aim of this study is collection and molecular identification of Candida species from gastroesophageal lesions among pediatrics in Isfahan, and determination of minimum inhibitory concentration (MIC) ranges for clinical isolates...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28894714/quantification-of-cdr1-gene-expression-in-fluconazole-resistant-candida-glabrata-strains-using-real-time-pcr
#5
Shadi Shahrokhi, Fatemeh Noorbakhsh, Sassan Rezaie
BACKGROUND: The opportunistic fungi, particularly Candida glabrata has been known as main etiologic agents of life-threating infections in some patients. Although fluconazole is the most effective antifungal agent against candidiasis, C. glabrata, fluconazole-resistant strains have been increased recently overexpression or mutations of ATP-binding cassette (ABC) transporter family membrane proteins such as; Cg CDR1, Cg CDR2 are responsible for fluconazole resistance in a large proportion of candidiasis cases...
August 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28893036/oral-candidal-carriage-in-subjects-with-pure-vegetarian-and-mixed-dietary-habits
#6
Shankargouda Patil, Roopa S Rao, A Thirumal Raj, D S Sanketh, Sachin Sarode, Gargi Sarode
INTRODUCTION: Candida albicans being a part of the normal oral microbial flora is one of the most commonly isolated species from the oral cavity. Recent studies have shown a steady rise in the number of non C. albicans species, which are relatively resistant to common antifungal agents and are being recognized as potential pathogens. It is vital to ascertain the predisposing factors leading to such a shift in the oral candidal flora. AIM: To estimate the prevalence of candidal species among vegetarians and non-vegetarians...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28886952/clinical-manifestations-of-candidemia-caused-by-uncommon-candida-species-and-antifungal-susceptibility-of-the-isolates-in-a-regional-hospital-in-taiwan-2007-2014
#7
Wei-Lun Liu, Chih-Cheng Lai, Ming-Chi Li, Chi-Jung Wu, Wen-Chien Ko, Yi-Li Hung, Hung-Jen Tang, Po-Ren Hsueh
OBJECTIVE: This retrospective study investigated clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan. METHODS: The uncommon Candida species was initially defined as Candida species other than C. albicans, C. tropicalis, C. glabrata complex, C. parapsilosis complex and C. krusei. All uncommon Candida isolates were identified and confirmed by molecular methods. In vitro susceptibility testing of the uncommon Candida species to nine antifungal agents was conducted using the broth microdilution method with the Sensititre YeastOne (SYO) system (Trek Diagnostic Systems, Ltd...
August 26, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28882010/invasive-candidiasis-in-the-neutropenic-patient
#8
REVIEW
J Fortún, F Gioia
There are major differences in the epidemiology and prognosis of invasive candidiasis and candidemia in the neutropenic patient; however, a recent study performed in Spanish hospitals (Candipop) confirmed that mortality at 1 month is 30%, which is similar to that observed in the general population. Although Candida albicans is the most frequently isolated species, C. tropicalis, C. glabrata, and C. krusei are more prevalent than in non-neutropenic patients. The benefit of neutrophil transfusion is unclear, and catheter withdrawal must be tailored and based on confirmation of the diagnosis...
September 2017: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/28876392/antifungal-and-antioxidant-activity-of-fatty-acid-methyl-esters-from-vegetable-oils
#9
Maria E A Pinto, Sthéfane G Araújo, Marcela I Morais, Nívea P Sá, Caroline M Lima, Carlos A Rosa, Ezequias P Siqueira, Susana Johann, Luciana A R S Lima
Fatty acid methyl esters (FAMEs) were obtained from vegetable oils of soybean, corn and sunflower. The current study was focused on evaluating the antifungal activity of FAMEs mainly against Paracoccidioides spp., as well as testing the interaction of these compounds with commercial antifungal drugs and also their antioxidant potential. FAMEs presented small IC50 values (1.86-9.42 μg/mL). All three FAMEs tested showed antifungal activity against isolates of Paracoccidioides spp. with MIC values ranging from 15...
August 31, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28872714/microbial-epidemiology-of-candidemia-in-neonatal-and-pediatric-intensive-care-units-at-children-s-medical-center-tehran
#10
Arezu Charsizadeh, Hossein Mirhendi, Bahram Nikmanesh, Hamid Eshaghi, Koichi Makimura
Invasive candidiasis is a major cause of morbidity and mortality in children. However, limited data is available on the epidemiology of this infection in pediatric settings in Iran. The aim of the present study was to determine the prevalence, microbial epidemiology, risk factors, and clinical outcomes associated with candidemia in intensive care units at Children's Medical Center, Tehran, Iran. All blood and other normally sterile specimen cultures positive for Candida species, were included. Isolates were identified by morphological and molecular methods...
September 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28872706/candida-bloodstream-infections-in-serbia-first-multi-center-report-of-a-national-prospective-observational-survey-in-intensive-care-units
#11
Valentina Arsić Arsenijević, Suzana Otašević, Dragana Janić, Predrag Minić, Jovan Matijašević, Deana Medić, Ivanka Savić, Snežana Delić, Suzana Laban Nestorović, Zorica Vasiljević, Mirjana Hadnadjev
Candida bloodstream infections (BSI) are a significant cause of mortality in intensive care units (ICU), hereof the prospective twelve-months (2014-2015) hospital and laboratory-based survey was performed at the Serbian National Reference Medical Mycology Laboratory (NRMML). Candida identification was done by a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and a susceptibility test, according to the Clinical and Laboratory Standards Institute methodology. Among 9 centers (265 beds; 10...
September 5, 2017: Mycoses
https://www.readbyqxmd.com/read/28869083/antifungal-effect-of-cow-s-urine-distillate-on-candida-species
#12
J M Hoh, B Dhanashree
BACKGROUND: Increase in resistance of Candida species, to routinely used antifungal agents has necessitated the quest for new drugs. Few studies have revealed that cow's urine can suppress the growth of pathogenic fungi. However there is no published report on antifungal effects of cow's urine on clinical Candida isolates. OBJECTIVE: The present study aims at exploring the antifungal potential of cow's urine on clinical isolates of Candida species. MATERIAL & METHODS: In this in-vitro experimental study four standard strains and 37 clinical isolates of Candida species were tested for their susceptibility to amphotericin B, fluconazole and voriconazole, by disk diffusion method...
August 30, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28865795/insights-into-the-molecular-basis-for-substrate-binding-and-specificity-of-the-fungal-cystine-transporter-cgcyn1
#13
Anup Arunrao Deshpande, Monika Sharma, Anand Kumar Bachhawat
Cystine transporters are a clinically important class of transporters found in bacteria, pathogenic fungi and mammalian cells. Despite their significance, very little is known about the mechanism of substrate recognition and transport. We have carried out studies on the plasma membrane Candida glabrata cystine transporter, CgCYN1 a member of the amino acid-polyamine-organocation (APC) transporter superfamily. A homology model of CgCYN1 was generated by using crystal structures of three known bacterial APC transporters followed by further refinement using molecular dynamics simulations...
September 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28842359/isocoumarin-derivatives-from-the-endophytic-fungus-pestalotiopsis-sp
#14
Ren-Yu Song, Xiao-Bing Wang, Guo-Ping Yin, Rui-Huan Liu, Ling-Yi Kong, Ming-Hua Yang
Five new isocoumarin derivatives, pestalactone A-C (1-3) and pestapyrone D-E (4-5), together with two known compounds (6-7) were isolated from the solid cultures of the endophytic fungus Pestalotiopsis sp. obtained from Photinia frasery. Their structures were mainly determined by extensive spectroscopic analysis, Mo2(OCOCH3)4-induced electronic circular dichroism (ECD), and ECD calculation. Compounds 1 and 2 were rare isocoumarin derivatives and derived from distinctive polyketide pathways. Compound 3 exhibited potent antifungal activity against Candida glabrata (ATCC 90030) with an MIC50 value of 3...
August 23, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28838629/in-vitro-antifungal-activity-of-cassia-fistula-extracts-against-fluconazole-resistant-strains-of-candida-species-from-hiv-patients
#15
P Sony, M Kalyani, D Jeyakumari, I Kannan, R G Sukumar
BACKGROUND: Candida species is the fourth common cause of blood stream infections all over the world which is life threatening. Invasive candidiasis leads to increased mortality and morbidity especially in immunosuppressed. The antifungal resistance pattern in high-risk patients is major concern. PURPOSE: The present study was to access the anticandidal activity of leaves, bark and seeds of Cassia fistula against fluconazole resistant Candida species, C. albicans, C...
August 21, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28831255/stratum-corneum-lipid-liposome-encapsulated-panomycocin-preparation-characterization-and-the-determination-of-antimycotic-efficacy-against-candida-spp-isolated-from-patients-with-vulvovaginitis-in-an-in-vitro-human-vaginal-epithelium-tissue-model
#16
Fatih İzgü, Günce Bayram, Kübra Tosun, Demet İzgü
In this study, a liposomal lyophilized powder formulation of panomycocin was developed for therapeutic purposes against vulvovaginal candidiasis which affects 80% of women worldwide. Panomycocin is a potent antimycotic protein secreted by the yeast Wickerhamomyces anomalus NCYC 434. This study involved the preparation of panomycocin-loaded stratum corneum lipid liposomes (SCLLs), characterization of the SCLLs, and determination of antimycotic efficacy of the formulation against Candida albicans and Candida glabrata clinical vaginal isolates in a human vaginal epithelium tissue model...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28831086/potential-use-of-maldi-tof-mass-spectrometry-for-rapid-detection-of-antifungal-resistance-in-the-human-pathogen-candida-glabrata
#17
Antonietta Vella, Elena De Carolis, Enrica Mello, David S Perlin, Dominique Sanglard, Maurizio Sanguinetti, Brunella Posteraro
The echinocandins are relatively new antifungal drugs that represent, together with the older azoles, the recommended and/or preferred agents to treat candidaemia and other forms of invasive candidiasis in human patients. If "time is of the essence" to reduce the mortality for these infections, the administration of appropriate antifungal therapy could be accelerated by the timely reporting of laboratory test results. In this study, we attempted to validate a MALDI-ToF mass spectrometry-based assay for the antifungal susceptibility testing (AFST) of the potentially multidrug-resistant pathogen Candida glabrata against anidulafungin and fluconazole...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28827419/antifungal-activity-of-scy-078-and-standard-antifungal-agents-against-178-clinical-isolates-of-resistant-and-susceptible-candida-species
#18
Wiley A Schell, A M Jones, Katyna Borroto-Esoda, Barbara D Alexander
SCY-078 in vitro activity was determined for 178 isolates of resistant and susceptible C. albicans, C. dubliniensis, C. glabrata, C. krusei, C. lusitaniae, and C. parapsilosis, including 44 Candida isolates having known genotypic (FKS1 or FKS2 mutations), phenotypic or clinical resistance to echinocandins. Results were compared to those for anidulafungin, caspofungin, micafungin, fluconazole and voriconazole. SCY-078 was shown to have excellent activity against both wild-type isolates and echinocandin- and azole-resistant isolates of Candida species...
August 21, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28826987/in-vitro-potency-and-fungicidal-activity-of-cd101-a-novel-echinocandin-against-recent-clinical-isolates-of-candida-spp
#19
Danielle Hall, Robert Bonifas, Lauretta Stapert, Mary Thwaites, Dean L Shinabarger, Chris M Pillar
Candida infections vary in severity and manifestation. Common infections include invasive bloodstream infections among hospitalized/immunocompromised patients and vulvovaginal candidiasis among women. Echinocandins and azoles are commonly utilized to treat Candida infections, although echinocandin use has been restricted to indications amenable to once-daily IV administration. CD101, a novel echinocandin with a long plasma half-life and enhanced stability, is in development for once-weekly IV administration for the treatment of candidemia and invasive candidiasis...
July 21, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28822858/comparison-of-genome-engineering-using-the-crispr-cas9-system-in-c-glabrata-wild-type-and-lig4-strains
#20
Yuke Cen, Bea Timmermans, Ben Souffriau, Johan M Thevelein, Patrick Van Dijck
Candida glabrata is reported as the second most prevalent human opportunistic fungal pathogen in North America and is threatening patients all over the world. Its incidence is rising, while it has developed resistance to the most widely used antifungal drugs, necessitating new approaches based on better insight into the biology of the organism. Despite its close phylogenetic relationship with Saccharomyces cerevisiae, generating precise genomic alterations in this species is problematic. Previously we have shown that deletion of LIG4, which encodes an enzyme involved in Non-Homologous End Joining (NHEJ), strongly enhances the probability of obtaining correctly modified transformants...
October 2017: Fungal Genetics and Biology: FG & B
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