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Candida glabrata

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https://www.readbyqxmd.com/read/29142743/anti-candida-activity-of-antimicrobial-impregnated-central-venous-catheters
#1
L Cobrado, A Silva-Dias, M M Azevedo, A Rodrigues
Background: Whenever the rate of central line-associated bloodstream infections (CLABSIs) remains high even after the implementation of preventive strategies, the use of chlorhexidine/silver sulfadiazine (CSS) or minocycline/rifampin (MR)-impregnated central venous catheters (CVCs) is currently recommended. Nevertheless, the efficacy of such CVCs against Candida albicans and other emerging non-albicans spp. has been insufficiently studied. This study aims to compare the activity of CSS and MR-impregnated CVCs against the yeasts most frequently isolated from CLABSIs...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29139623/extracellular-proteinases-of-candida-species-pathogenic-yeasts
#2
Maria Rapala-Kozik, Oliwia Bochenska, Dorota Zajac, Justyna Karkowska-Kuleta, Mariusz Gogol, Marcin Zawrotniak, Andrzej Kozik
The increased incidence of severe disseminated infections caused by opportunistic yeast-like fungi Candida spp. highlights the urgent need for research into the major virulence factors of these pathogens - extracellular aspartic proteinases of the candidapepsin and yapsin families. Classically, these enzymes were considered to be generally destructive factors that damage host tissues and provide nutrients for pathogen propagation. However, in recent decades, novel and more specific functions have been suggested for extracellular candidal proteinases...
November 15, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/29132935/risk-factors-and-outcomes-of-candidemia-caused-by-candida-parapsilosis-complex-in-a-medical-center-in-northern-taiwan
#3
Yen-Mu Wu, Po-Yen Huang, Jang-Jih Lu, Shian-Sen Shie, Jung-Jr Ye, Ting-Shu Wu, Ching-Tai Huang
To investigate the risk factors and outcomes associated with Candida parapsilosis candidemia, a retrospective study was conducted at a tertiary medical center in northern Taiwan. Patients with C. parapsilosis candidemia and corresponding controls with C. albicans candidemia were chosen and their demographics, comorbidities, risk factors, and clinical outcomes were reviewed. Antifungal susceptibility tests were performed using the Sensititre YeastOne colorimetric system. Matrix-assisted laser desorption ionization-time of flight mass spectrometry was used to classify the genomic species...
October 6, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29129987/increasing-the-fungicidal-action-of-amphotericin-b-by-inhibiting-the-nitric-oxide-dependent-tolerance-pathway
#4
Kim Vriens, Phalguni Tewari Kumar, Caroline Struyfs, Tanne L Cools, Pieter Spincemaille, Tadej Kokalj, Belém Sampaio-Marques, Paula Ludovico, Jeroen Lammertyn, Bruno P A Cammue, Karin Thevissen
Amphotericin B (AmB) induces oxidative and nitrosative stresses, characterized by production of reactive oxygen and nitrogen species, in fungi. Yet, how these toxic species contribute to AmB-induced fungal cell death is unclear. We investigated the role of superoxide and nitric oxide radicals in AmB's fungicidal activity in Saccharomyces cerevisiae, using a digital microfluidic platform, which enabled monitoring individual cells at a spatiotemporal resolution, and plating assays. The nitric oxide synthase inhibitor L-NAME was used to interfere with nitric oxide radical production...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29109313/evaluation-of-the-antifungal-effect-of-chicory-extracts-on-candida-glabrata-and-candida-krusei-in-a-laboratory-environment
#5
Hosein Eslami, Hossein Babaei, Parisa Falsafi, Mahdi Rahbar, Fereshteh Najar-Karimi, Solmaz Pourzare-Mehrbani
AIM: This research has evaluated the extract's antifungal effects on Candida glabrata and Candida krusei in a laboratory environment. MATERIALS AND METHODS: In this research, to evaluate the antifungal effect and the minimal inhibitory concentration (MIC) determination of chicory extract, the Clinical and Laboratory Standards Institute (CLSI) was used. Candida glabrata and C. krusei funguses were procured from the Tehran Pasteur Institute; they were grown in the relative growing environment according to the required conditions...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29105633/evaluation-of-antimicrobial-cytotoxic-and-genotoxic-activities-of-ganoderma-lucidum-reishi-mushroom
#6
Bulent Ergun
Ganoderma lucidum (GL) is a mushroom used as a traditional remedy for the treatment of various infections since ancient times. This study, was aimed to investigate antimicrobial activity potential of GL against Staphylococcus aureus, Enterococcus faecalis, Listeria monocytogenes, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Candida glabrata, Candida krusei, and Candida parapsilopsis. Furthermore, it was also aimed to evaluate the toxicity potential of GL. Antimicrobial activities were screened by using microbroth dilution method...
September 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29104569/a-linear-19-mer-plant-defensin-derived-peptide-acts-synergistically-with-caspofungin-against-candida-albicans-biofilms
#7
Tanne L Cools, Caroline Struyfs, Jan W Drijfhout, Soňa Kucharíková, Celia Lobo Romero, Patrick Van Dijck, Marcelo H S Ramada, Carlos Bloch, Bruno P A Cammue, Karin Thevissen
Public health problems are associated with device-associated biofilm infections, with Candida albicans being the major fungal pathogen. We previously identified potent antibiofilm combination treatment in which the antifungal plant defensin HsAFP1 is co-administered with caspofungin, the preferred antimycotic to treat such infections. In this study, we identified the smallest linear HsAFP1-derived peptide that acts synergistically with caspofungin or anidulafungin against C. albicans as HsLin06_18, a 19-mer peptide derived from the C-terminal part of HsAFP1...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29099103/detecci%C3%A3-n-molecular-de-especies-de-candida-en-espec%C3%A3-menes-de-pacientes-hospitalizados
#8
José Luis Camacho-Cardoso, María Ángeles Martínez-Rivera, Patricia Manzano-Gayosso, Luis Javier Méndez-Tovar, Rubén López-Martínez, Francisca Hernández-Hernández
Objective: To identify the most frequent Candida species in specimens from patients hospitalized in different medical centers of Mexico City, with suspected fungal infection. Methods: Specimens were grown on Sabouraud dextrose agar at 28°C for 72 h. In addition, DNA was extracted. Isolates were grown on CHROMagar Candida™, at 37°C for 48 h. The molecular identification was performed by polymerase chain reaction (PCR) using primers specific for four species. Results: Eighty one specimens were processed and included: bronchial lavage, pleural, cerebrospinal, peritoneal, ascites and bile fluids; blood, sputum, bone marrow, oro-tracheal cannula and ganglion...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29097168/synthesis-and-biological-evolution-of-hydrazones-derived-from-4-trifluoromethyl-benzohydrazide
#9
Martin Krátký, Szilvia Bősze, Zsuzsa Baranyai, Jiřina Stolaříková, Jarmila Vinšová
Reflecting the known biological activity of isoniazid-based hydrazones, seventeen hydrazones of 4-(trifluoromethyl)benzohydrazide as their bioisosters were synthesized from various benzaldehydes and aliphatic ketones. The compounds were screened for their in vitro activity against Mycobacterium tuberculosis, nontuberculous mycobacteria (M. avium, M. kansasii), bacterial and fungal strains. The most antimicrobial potent derivatives were also investigated for their cytostatic and cytotoxic properties against three cell lines...
October 21, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29096684/antifungal-susceptibility-and-phenotypic-virulence-markers-of-candida-species-isolated-from-nepal
#10
Supram Hosuru Subramanya, Bharat Prasad Baral, Nawal Kishor Sharan, Niranjan Nayak, Yang Metok, Brijesh Sathian, Indira Bairy, Shishir Gokhale
OBJECTIVE: Candida species are part of the commensal microflora in many anatomical sites of the human body; however, breach in the integrity of the body part and impaired immunity of the host can lead to invasive candidiasis. A number of virulence determinants could contribute towards its pathogenicity. Thus we attempted to evaluate the in vitro expression of different virulence factors among clinical isolates of Candida species and assayed their susceptibility patterns against a range of antifungal agents...
November 2, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29095200/emerging-multidrug-resistant-candida-species
#11
Arnaldo L Colombo, João N de Almeida Júnior, Jesus Guinea
PURPOSE OF REVIEW: To describe the epidemiology, strategies for early detection, and clinical management of infections caused by the most commonly found multidrug-resistant (MDR) Candida spp. RECENT FINDINGS: Increasing numbers of reports describing invasive infections by MDR Candida auris and Candida glabrata has been reported in medical centers worldwide. SUMMARY: We checked all papers published along the last 10 years describing epidemiological, diagnostic, and clinical aspects of infections by MDR Candida spp...
December 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29081438/two-spotted-cricket-as-an-animal-infection-model-of-human-pathogenic-fungi
#12
Yuto Kochi, Yasuhiko Matsumoto, Kazuhisa Sekimizu, Chikara Kaito
Invertebrate infection models that can be evaluated at human body temperature are limited. In this study, we utilized the two-spotted cricket, a heat-tolerant insect, as an animal infection model of human pathogenic fungi. Injection of human pathogenic fungi, including Candida albicans, Candida glabrata, and Cryptococcus neoformans killed crickets within 48 h at both 27˚C and 37˚C. The median lethal dose values (LD50 values) of C. albicans and C. glabrata against crickets were decreased at 37˚C compared to that at 27˚C, whereas the LD50 value of C...
October 29, 2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/29080936/detection-of-candida-species-by-nested-pcr-method-in-one-humped-camels-camelus-dromedarius
#13
Ugur Parin, Goksel Erbas, Sukru Kirkan, Serap Savasan, H Tugba Yuksel, Gamze Balat
Systemic fungal diseases are the infections caused by false treatment protocols and generally are not taken into consideration especially in the veterinary field. One-humped camels are found in the western side of the Aegean region of our country and bred for wrestling. The aim of this study is the application of diagnosing systemic fungi infection from camel blood samples by the PCR method. In this study, specific primers for DNA topoisomerase II gene sequences were used. As a result, a systemic fungal infection was detected by the nested PCR method from 10 (20%) out of 50 DNA samples taken from camels located on the western side of the Aegean region...
October 28, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29079259/endoscopic-endonasal-transsphenoidal-drainage-of-a-spontaneous-candida-glabrata-pituitary-abscess-case-report-intraoperative-video
#14
Ben A Strickland, Martin Pham, Joshua Bakhsheshian, John Carmichael, Martin Weiss, Gabriel Zada
Noniatrogenic pituitary abscesses remain a rare clinical entity, and are the indication for surgery in <1% of transsphenoidal approaches. Correct diagnosis of this rare entity is often delayed. Without timely treatment, morbidity and mortality are high. Of the 200 cases reported, less than half have identified a causative organism. We report the second case of a pituitary abscess caused by Candida species, and further provide intraoperative video of endoscopic management of this pathology. A 33-year-old woman presented with headache, hypopituitarism, and vision loss in the setting of diabetic ketoacidosis, and was found to have multiple abscesses in the liver, lung, kidney, and uterus...
October 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29076587/high-prevalence-of-candiduria-due-to-non-albicans-candida-species-among-diabetic-patients-a-matter-of-concern
#15
Alireza Esmailzadeh, Hossein Zarrinfar, AbdolMajid Fata, Tanuka Sen
BACKGROUND: Among the fungal pathogens, Candida species are the most common cause of urinary tract infection (UTI). Some predisposing factors such as diabetes mellitus, urinary retention, urinary stasis, renal transplantation, and hospitalization can increase the risk of candiduria. The aim of this cross-sectional study was to evaluate candiduria among type 2 diabetic patients and identification of the Candida isolates. METHOD: Four hundred clean-catch midstream urine specimens were obtained from patients with type 2 diabetes mellitus...
October 27, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29074432/healthcare-workers-hands-as-a-vehicle-for-the-transmission-of-virulent-strains-of-candida-spp-a-virulence-factor-approach
#16
Karina Mayumi Sakita, Daniella Renata Faria, Eliane Martins da Silva, Flávia Kelly Tobaldini-Valério, Erika Seki Kioshima, Terezinha Inez Estivalet Svidzinski, Patricia de Souza Bonfim-Mendonça
BACKGROUND: Although the majority of Candida infections are thought to come from endogenous sources, the healthcare workers' (HCWs) hands are being increasingly reported as vehicles for the transmission of pathogens. The aim of the present study was to evaluate the susceptibility of yeast isolated from the HCWs' hands and ICU (Intensive Care Unit) surfaces to antifungal agents and to determine the virulence potential and the genetic similarity between the same. METHODS: The susceptibility of yeasts from the HCWs' hands (n = 57) and ICU surfaces (n = 98) to conventional antifungals (fluconazole, voriconazole, amphotericin B and micafungin) was evaluated using the broth microdilution assay accordance with CLSI M27-A3...
October 23, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29069395/polymorphism-in-the-regulatory-regions-of-genes-cgyps1-and-cgyps7-encoding-for-yapsins-in-candida-glabrata-is-associated-to-changes-in-expression-levels
#17
Cortés-Acosta Elías, Ibarra J Antonio, Ramírez-Saad Hugo, Vargas-Mendoza C Fabián, Villa-Tanaca Lourdes, Hernández-Rodríguez César
Candida glabrata is an opportunistic fungus infecting mainly immunocompromised people. Its adherence capacity and exoenzymes contribute to damage host cells. Particularly, the yapsins are a family of aspartyl proteases involved in maturation of proteins and cell wall function. Yapsin 1 and 7, respectively encoded by genes CgYPS1 and CgYPS7 , are potential virulence factors. In this study, the polymorphism of regulatory regions and the expression profiles of the both genes were compared on C. glabrata clinical strains...
October 23, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/29062248/evaluation-of-candida-species-and-antifungal-susceptibilities-among-children-with-invasive-candidiasis
#18
Murat Sütçü, Manolya Acar, Gonca Erköse Genç, İlknur Kökçü, Hacer Aktürk, Gürkan Atay, Selda Hançerli Törun, Nuran Salman, Zayre Erturan, Ayper Somer
AIM: Non-albicans Candida species and resistant microorganisms have been more commonly isolated in invasive candidiasis in recent years. The aim of this study was to evaluate the distrubution of Candida spp and antifungal resistance in our clinic. MATERIAL AND METHODS: Fifty-four Candida isolates and antifungal susceptibility results obtained from patients diagnosed as having invasive candidiasis between December 2012 and June 2016 were included. Clinical and laboratory data were retrospectively analyzed...
September 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/29054522/antimicrobial-activity-of-a-newly-identified-kazal-type-serine-proteinase-inhibitor-cckpi1-from-the-jellyfish-cyanea-capillata
#19
Yonghong Zhou, Guoyan Liu, Xi Cheng, Qianqian Wang, Bo Wang, Beilei Wang, Hui Zhang, Qian He, Liming Zhang
In this study, we reported a jellyfish-derived Kazal-type serine protease inhibitor, named CcKPI1, from Cyanea capillata. CcKPI1 has a calculated molecular mass of 19.02kDa and contains three typical Kazal domains. Soluble recombinant CcKPI1 (rCcKPI1) was successfully expressed and purified. rCcKPI1 exhibited significant inhibitory activities against elastase, subtilisin A and proteinase K, but not against trypsin or chymotrypsin. Kinetic studies showed that all of the inhibitory effects of rCcKPI1 were competitive, indicating that it may be a microbial serine protease inhibitor and can exhibit antimicrobial activity...
October 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29046411/rapid-detection-and-differentiation-of-clinically-relevant-candida-species-simultaneously-from-blood-culture-using-a-novel-signal-amplification-approach
#20
Wanyuan Ao, Joshua Klonoski, Eric Berlinghoff, Jordan Jensen, Taliman Afroz, Denton Munns, Wes Lindsey, Gerald Denys, Robert Jenison
Fungal blood-stream infections are a significant problem in the U.S. with an attributable mortality rate of up to 40%. Early diagnosis to direct appropriate therapy has been shown to be critical to reduce mortality rates. Conventional phenotypic methods for fungal detection take several days, which is often too late to impact outcomes. Herein, we describe a cost-effective multiplex assay platform for rapid detection and differentiation of major clinically relevant Candida species directly from blood culture...
October 18, 2017: Journal of Clinical Microbiology
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