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https://www.readbyqxmd.com/read/29908488/effect-of-dissolution-of-magnesium-alloy-az31-on-the-rheological-properties-of-phosphate-buffer-saline
#1
Usman Riaz, Leela Rakesh, Ishraq Shabib, Waseem Haider
The issue of long-term incompatible interactions associated with the permanent implants can be eliminated by using various biodegradable metal implants. The recent research is focusing on the use of degradable stents to restore most of the hindrances of capillaries, and coronary arteries by supplying instant blood flow with constant mechanical and structural support. However, internal endothelialization and infection due to the corrosion of implanted stents are not easy to diagnose in the long run. In the recent past, magnesium (Mg) has been widely investigated for the cardiovascular stent applications...
June 5, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29908256/the-protective-effect-of-%C3%AE-lipoic-acid-against-bisphenol-a-induced-neurobehavioral-toxicity
#2
Jasim Khan, Shikha Salhotra, Shahzad Ahmad, Shikha Sharma, Sayed Aliul Hasan Abdi, Basu Dev Banerjee, Suhel Parvez, Sarika Gupta, Sheikh Raisuddin
Bisphenol A (BPA), a well-known xenoestrogen, is ubiquitously utilized in manufacturing of polycarbonated plastics. Convincing evidence suggests that BPA induces neurotoxicity and certain behavioral deficits. α-Lipoic acid (ALA) supplementation has shown protective effect against heart and liver diseases, diabetes, and neurological debility associated with aging. We studied the neuromodulatory effect of ALA against neurotoxicity of BPA in vitro in C8-D1A mouse astrocyte cell line and in vivo in C57BL/6J male mice...
June 13, 2018: Neurochemistry International
https://www.readbyqxmd.com/read/29908236/taking-one-for-the-team-physiological-trajectories-of-painful-intergroup-retaliation
#3
Elizabeth M Niedbala, Zachary P Hohman, Breanna N Harris, Alexandra C Abide
Retaliating against a threatening outgroup offers group members specific rewards, such as restored group esteem, a reduction in anger, and a sense of gratification. Because retaliation is rewarding, group members may appraise an attack on the outgroup to be beneficial, even if it feels physically painful. We hypothesized that group members would be more willing to endure pain to retaliate against a threatening outgroup, and that appraising the painful retaliation as rewarding would down-regulate their physiological stress response to pain...
June 13, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29908183/mif-protects-against-oxygen-glucose-deprivation-induced-ototoxicity-in-hei-oc1-cochlear-cells-by-enhancement-of-akt-nrf2-ho-1-pathway
#4
Wen-Yan Zhu, Xin Jin, Yong-Chi Ma, Zhi-Biao Liu
Ischemia and oxidative stress play crucial roles in the pathophysiology of sudden sensorineural hearing loss (SSNHL). Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine and serves an important role in hearing function. The present study was designed to evaluate the effect of MIF on oxygen-glucose deprivation (OGD)-induced ototoxicity and to elucidate its molecular mechanism. In HEI-OC1 auditory cells, OGD reduced cell viability and increased supernatant lactate dehydrogenase (LDH) and MIF in a time-dependent manner...
June 13, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29907996/potentialities-of-efficient-and-resistant-plant-growth-promoting-rhizobacteria-in-pb-uptake-and-defensive-system-stimulation-of-lathyrus-sativus-under-lead-stress
#5
Souhir Abdelkrim, Salwa Harzalli Jebara, Omar Saadani, Moez Jebara
The ability of Plant Growth Promoting Rhizobateria (PGPR) to enhance Lathyrus sativus tolerance to lead (Pb) stress was investigated. Ten consortia formed by mixing four efficient and Pb-resistant PGPR strains were assessed for their beneficial effect in improving Pb (0.5 mM) uptake and in inducing host-defensive system of L. sativus under hydroponic conditions based on various physiological and biochemical parameters. Pb stress significantly decreased shoot and root dry weight but inoculation improves these biomasses with highest increases registred in SDW and RDW of plants inoculated with I5 (R...
June 15, 2018: Plant Biology
https://www.readbyqxmd.com/read/29907819/genome-wide-transcriptional-analysis-of-submerged-lotus-reveals-cooperative-regulation-and-gene-responses
#6
Bei Wang, Qijiang Jin, Xiao Zhang, Neil S Mattson, Huihui Ren, Jing Cao, Yanjie Wang, Dongrui Yao, Yingchun Xu
Flooding severely limits plant growth even for some aquatic plants. Although much work has been done on submergence response of some important crop plants, little is known about the response mechanism of aquatic plants, i.e. lotus (Nelumbo nucifera). In this study, we investigated the genome-wide regulation lotus genes in response to submergence stress by high-throughput mRNA sequencing. A total of 4002 differentially expressed genes (DEGs) in lotus upon submergence stress. Among them, 1976 genes were up-regulated and 2026 down-regulated...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907813/early-life-and-pubertal-stress-differentially-modulate-grey-matter-development-in-human-adolescents
#7
Anna Tyborowska, Inge Volman, Hannah C M Niermann, J Loes Pouwels, Sanny Smeekens, Antonius H N Cillessen, Ivan Toni, Karin Roelofs
Animal and human studies have shown that both early-life traumatic events and ongoing stress episodes affect neurodevelopment, however, it remains unclear whether and how they modulate normative adolescent neuro-maturational trajectories. We characterized effects of early-life (age 0-5) and ongoing stressors (age 14-17) on longitudinal changes (age 14 to17) in grey matter volume (GMV) of healthy adolescents (n = 37). Timing and stressor type were related to differential GMV changes. More personal early-life stressful events were associated with larger developmental reductions in GMV over anterior prefrontal cortex, amygdala and other subcortical regions; whereas ongoing stress from the adolescents' social environment was related to smaller reductions over the orbitofrontal and anterior cingulate cortex...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907803/effect-of-temperature-on-burkholderia-pseudomallei-growth-proteomic-changes-motility-and-resistance-to-stress-environments
#8
Suporn Paksanont, Kitisak Sintiprungrat, Thatcha Yimthin, Pornpan Pumirat, Sharon J Peacock, Narisara Chantratita
Burkholderia pseudomallei is a flagellated, gram-negative environmental bacterium that causes melioidosis, a severe infectious disease of humans and animals in tropical areas. We hypothesised that B. pseudomallei may undergo phenotypic adaptation in response to an increase in growth temperature. We analysed the growth curves of B. pseudomallei strain 153 cultured in Luria-Bertani broth at five different temperatures (25 °C-42 °C) and compared the proteomes of bacteria cultured at 37 °C and 42 °C...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907698/selective-activation-of-retinoic-acid-%C3%AE-2-receptors-exerts-cardioprotective-effects
#9
Alice Marino, Takuya Sakamoto, Xiao-Han Tang, Lorraine J Gudas, Roberto Levi
We previously discovered that oral treatment with AC261066, a synthetic selective agonist for the retinoic acid β2-receptor (RARβ2), decreases oxidative stress in the liver, pancreas, and kidney of mice fed a high-fat diet (HFD). Since hyperlipidemic states are causally associated with myocardial ischemia and oxidative stress, we have now investigated the effects of AC261066 in an ex-vivo ischemia/reperfusion (I/R) injury model in hearts of two prototypic dysmetabolic mice. We found that a 6-week oral treatment with AC261066 in both genetically hypercholesterolemic (ApoE-/-) and obese (HFD-fed) wild-type mice exerts protective effects when their hearts are subsequently subjected to I/R ex vivo in the absence of added drug...
June 15, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29907153/comparison-of-two-low-fat-diets-differing-in-protein-and-carbohydrate-on-psychological-wellbeing-in-adults-with-obesity-and-type-2-diabetes-a-randomised-clinical-trial
#10
Nerylee Ann Watson, Kathryn Ann Dyer, Jonathan David Buckley, Grant David Brinkworth, Alison Mary Coates, Gaynor Parfitt, Peter Ranald Charles Howe, Manny Noakes, Karen Joy Murphy
BACKGROUND: Although higher-protein diets (HP) can assist with weight loss and glycemic control, their effect on psychological wellbeing has not been established. The objective of this study was to compare the effects of a HP and a higher-carbohydrate diet (HC), combined with regular exercise, on psychological wellbeing both during weight loss (WL) and weight maintenance phases (WM). METHODS: In a parallel RCT, 61 adults with T2D (mean ± SD: BMI 34.3 ± 5...
June 15, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29907043/rubber-friction-the-contribution-from-the-area-of-real-contact
#11
A Tiwari, N Miyashita, N Espallargas, B N J Persson
There are two contributions to the friction force when a rubber block is sliding on a hard and rough substrate surface, namely, a contribution Fad = τf A from the area of real contact A and a viscoelastic contribution Fvisc from the pulsating forces exerted by the substrate asperities on the rubber block. Here we present experimental results obtained at different sliding speeds and temperatures, and we show that the temperature dependency of the shear stress τf , for temperatures above the rubber glass transition temperature Tg , is weaker than that of the bulk viscoelastic modulus...
June 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29906537/phenolic-acid-and-flavonoid-rich-fraction-of-sasa-quelpaertensis-nakai-leaves-prevent-alcohol-induced-fatty-liver-through-ampk-activation
#12
Kalahe Hewage Iresha Nadeeka Madushani Herath, Jinhee Cho, Areum Kim, Tae Kil Eom, Ju-Sung Kim, Jae-Bum Kim, Yang Hoi Doh, Youngheun Jee
ETHNOPHARMACOLOGICAL RELEVANCE: Sasa quelpaertensis Nakai is an edible dwarf bamboo cultivated mainly in Jeju Island, South Korea and its leaf displays various health-promoting properties including antioxidant scavenging. AIM OF THE STUDY: In this study, we aimed at elucidating its hepatoprotective effect against alcohol-induced fatty liver. METHODS: In in vitro study, we evaluated the cytotoxicity and hepatoprotective effect of different solvent fractions (aqua, butanol, chloroform, ethyl acetate and hexane) of 80% EtOH extract of S...
June 12, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29906271/genome-wide-characterization-and-expression-analysis-of-citrus-nuclear-factor-y-nf-y-transcription-factors-identified-a-novel-nf-ya-gene-involved-in-drought-stress-response-and-tolerance
#13
Suzam L S Pereira, Cristina P S Martins, Aurizangela O Sousa, Luciana R Camillo, Caroline P Araújo, Grazielle M Alcantara, Danielle S Camargo, Luciana C Cidade, Alex-Alan F de Almeida, Marcio G C Costa
Nuclear factor Y (NF-Y) is a ubiquitous transcription factor found in eukaryotes. It is composed of three distinct subunits called NF-YA, NF-YB and NF-YC. NF-Ys have been identified as key regulators of multiple pathways in the control of development and tolerance to biotic and abiotic factors. The present study aimed to identify and characterize the complete repertoire of genes coding for NF-Y in citrus, as well as to perform the functional characterization of one of its members, namely CsNFYA5, in transgenic tobacco plants...
2018: PloS One
https://www.readbyqxmd.com/read/29905663/decreases-in-suicide-cognitions-after-cognitive-processing-therapy-among-veterans-with-posttraumatic-stress-disorder-due-to-military-sexual-trauma-a-preliminary-examination
#14
Ryan Holliday, Nicholas Holder, Lindsey L Monteith, Alina Surís
Posttraumatic stress disorder (PTSD) is associated with suicidal ideation (SI) and suicidal self-directed violence (SDV). Military sexual trauma (MST) is a common precursor to PTSD among veterans. Survivors of MST are more likely to be diagnosed with PTSD and are at greater risk for SI than survivors of other forms of trauma. Suicide-specific beliefs (e.g., unlovability, unbearability, unsolvability) have been shown to be strong predictors of SI and future suicidal SDV. Suicide-specific beliefs were examined over the course of treatment and follow-up in 32 veterans (23 women, 9 men) who received cognitive processing therapy (CPT) for MST-related PTSD...
June 14, 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29904354/paracrine-anti-inflammatory-effects-of-adipose-tissue-derived-mesenchymal-stem-cells-in-human-monocytes
#15
Maria I Guillén, Julia Platas, María D Pérez Del Caz, Vicente Mirabet, Maria J Alcaraz
The inflammatory process is an essential phenomenon in the induction of immune responses. Monocytes are key effector cells during the inflammatory process. A wide range of evidence indicates that mesenchymal stem cells from adipose tissue (ASC) are endowed with immunomodulatory capacity. However, the interaction between ASC and monocytes in the innate immune response is not well understood. The aim of this work was to investigate the possible paracrine anti-inflammatory effects of ASC in human monocytes. Monocytes were isolated from buffy coats and ASC from fat of non-obese patients...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29904353/low-level-light-therapy-protects-red-blood-cells-against-oxidative-stress-and-hemolysis-during-extracorporeal-circulation
#16
Tomasz Walski, Anna Drohomirecka, Jolanta Bujok, Albert Czerski, Grzegorz Wąż, Natalia Trochanowska-Pauk, Michał Gorczykowski, Romuald Cichoń, Małgorzata Komorowska
Aim: An activation of non-specific inflammatory response, coagulation disorder, and blood morphotic elements damage are the main side effects of the extracorporeal circulation (ECC). Red-to-near-infrared radiation (R/NIR) is thought to be capable of stabilizing red blood cell (RBC) membrane through increasing its resistance to destructive factors. We focused on the development of a method using low-level light therapy (LLLT) in the spectral range of R/NIR which could reduce blood trauma caused by the heart-lung machine during surgery...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29904183/midday-and-nadir-salivary-cortisol-appear-superior-to-cortisol-awakening-response-in-burnout-assessment-and-monitoring
#17
Alexander Pilger, Helmuth Haslacher, Bernhard M Meyer, Alexandra Lackner, Selma Nassan-Agha, Sonja Nistler, Claudia Stangelmaier, Georg Endler, Andrea Mikulits, Ingrid Priemer, Franz Ratzinger, Elisabeth Ponocny-Seliger, Evelyne Wohlschläger-Krenn, Manuela Teufelhart, Heidemarie Täuber, Thomas M Scherzer, Thomas Perkmann, Galateja Jordakieva, Lukas Pezawas, Robert Winker
Burnout and work-related stress symptoms of anxiety disorder and depression cause prolonged work absenteeism and early retirement. Hence, reliable identification of patients under risk and monitoring of treatment success is highly warranted. We aimed to evaluate stress-specific biomarkers in a population-based, "real-world" cohort (burnouts: n = 40, healthy controls: n = 26), recruited at a preventive care ward, at baseline and after a four-month follow up, during which patients received medical and psychological treatment...
June 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29902553/antioxidant-and-pro-oxidant-actions-of-resveratrol-on-human-serum-albumin-in-the-presence-of-toxic-diabetes-metabolites-glyoxal-and-methyl-glyoxal
#18
N M O Arcanjo, C Luna, M S Madruga, M Estévez
Methylglyoxal (MGO) and glyoxal (GO) are attracting considerable attention because of their role in the onset of diabetes symptoms. Therefore, to comprehend the molecular fundamentals of their pathological actions is of the utmost importance. In this study, the molecular interactions between resveratrol (RES) and human serum albumin (HSA) and the ability of the stilbene to counteract the oxidative damage caused by pathological concentrations of MGO and GO to the human plasma protein, was assessed. The oxidation of Cys34 in HSA as well as the formation of specific protein semialdehydes AAS (α-aminoadipic), GGS (γ-glutamic) and the accumulation of Advanced Glycation End-products (AGEs) was investigated...
June 11, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29902468/intravenous-immunoglobulin-ameliorates-motor-and-cognitive-deficits-and-neuropathology-in-r6-2-mouse-model-of-huntington-s-disease-by-decreasing-mutant-huntingtin-protein-level-and-normalizing-nf-%C3%AE%C2%BAb-signaling-pathway
#19
Shu-Ying Liu, Xiao-Lin Yu, Jie Zhu, Xiang-Meng Liu, Yue Zhang, Quan-Xiu Dong, Shan Ma, Rui-Tian Liu
Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive movement disorders and cognitive deficits, which is caused by a CAG-repeat expansion encoding an extended polyglutamine (polyQ) tract in the huntingtin protein (HTT). Reduction of mutant HTT levels and inhibition of neuroinflammation has been proposed as a major therapeutic strategy in treating HD. Intravenous immunoglobulin (IVIg) therapy has been firmly established for the treatment of several autoimmune or inflammatory neurological diseases, either as adjunctive treatment or as first-line therapy...
June 11, 2018: Brain Research
https://www.readbyqxmd.com/read/29902463/reno-protective-effects-of-tak-242-on-acute-kidney-injury-in-a-rat-model
#20
Bassim I Mohammad, Abdulla K Rahem, Najah R Hadi, Dina A Jamil, Hayder A Al-Aubaidy
Acute kidney inschemia/reperfusion (I/R) injury is characterized by an abrupt loss of kidney function, resulting in the retention of urea and other nitrogenous waste products and in the dysregulation of extracellular volume and electrolytes. Despite the advances in therapeutic techniques, the mortality and morbidity of patients remain high and have not appreciably improved. This study aims to evaluate the potential protective effect of TAK-242 on renal ischemia/reperfusion injury using an animal model. Thirty-five adult male Sprague-dawely rats (weighing 200-300), were assigned randomly into the following experimental groups (n = 7 in each group), Control (I/R), Sham (negative control), TAK-242 (5 mg/kg body weight), TAK-242 (10 mg/kg body weight) and Vehicle (DMSO)...
June 11, 2018: Biochemical and Biophysical Research Communications
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