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https://www.readbyqxmd.com/read/29458193/attenuation-of-neuro-inflammation-improves-survival-and-neurodegeneration-in-a-mouse-model-of-severe-neonatal-hyperbilirubinemia
#1
Simone Vodret, Giulia Bortolussi, Alessandra Iaconcig, Elena Martinelli, Claudio Tiribelli, Andrés F Muro
All pre-term newborns and a high proportion of term newborns develop neonatal jaundice. Neonatal jaundice is usually a benign condition and self-resolves within few days after birth. However, a combination of unfavorable complications may lead to acute hyperbilirubinemia. Excessive hyperbilirubinemia may be toxic for the developing nervous system leading to severe neurological damage and death by kernicterus. Survivors show irreversible neurological deficits such as motor, sensitive and cognitive abnormalities...
February 16, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29458130/impact-of-rna-polymerase-i-inhibitor-cx-5461-on-viral-kinase-dependent-and-independent-cytomegalovirus-replication
#2
Kristen N Westdorp, Scott S Terhune
Human cytomegalovirus (HCMV) infections cause congenital birth defects and disease in immunosuppressed individuals. Antiviral compounds can control infection yet their use is restricted due to concerns of toxicity and the emergence of drug resistant strains. We have evaluated the impact of an RNA Polymerase I (Pol I) inhibitor, CX-5461 on HCMV replication. CX-5461 inhibits Pol I-mediated ribosomal DNA transcription by binding G-quadruplex DNA structures and also activates cellular stress response pathways. The addition of CX-5461 at both early and late stages of the HCMV infection inhibited viral DNA synthesis and virus production...
February 16, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29458118/neuroprotective-effect-of-melatonin-against-lipopolysaccharide-induced-depressive-like-behavior-in-mice
#3
E H Taniguti, Y S Ferreira, I J V Stupp, E B Fraga-Junior, C B Mendonça, F L Rossi, H N Ynoue, D L Doneda, L Lopes, E Lima, Z S Buss, S Vandresen-Filho
Accumulating evidence indicates an interaction between inflammation and depression since increased levels of pro-inflammatory cytokines are associated with depression-related symptoms. Melatonin is a hormone synthesized and secreted by the pineal gland with antioxidant, anti-inflammatory and antidepressant-like effects. In this way, it would be interesting to evaluate the putative antidepressant-like effect of melatonin treatment in an acute inflammation mice model of depression. The present study aimed to investigate the effect of melatonin treatment on lipopolysaccharide (LPS) induced depressive-like behavior, neuroinflammation, oxidative stress and alteration on brain-derived neurotrophic fator (BDNF) levels...
February 16, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29458048/4-phenylbutyric-acid-protects-against-lipopolysaccharide-induced-bone-loss-by-modulating-autophagy-in-osteoclasts
#4
Hyun-Jung Park, Ho-Jung Son, Ok-Joo Sul, Jae-Hee Suh, Hye-Seon Choi
4-Phenylbutyric acid (4-PBA) has been used clinically to treat urea cycle disorders and is known to be an inhibitor of endoplasmic reticulum (ER) stress. We hypothesized that 4-PBA attenuates inflammatory bone loss by inducing autophagy, a process that is frequently accompanied by ER stress. Micro computerized tomography analysis showed that 4-PBA attenuated LPS-induced bone loss in mice. The increased area of TRAP-positive osteoclasts (OCs) and serum level of collagen type I fragments in lipopolysaccharide (LPS)-treated mice were also decreased when 4-PBA was administered, suggesting a protective role of 4-PBA in OCs...
February 16, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29457669/n-acetyl-cysteine-mediated-inhibition-of-spermatogonial-cells-apoptosis-against-malathion-exposure-in-testicular-tissue
#5
Jitender Kumar Bhardwaj, Priyanka Saraf, Priya Kumari, Meenu Mittal, Vijay Kumar
Toxicological studies so far suggest that excessive use of malathion, an organophosphate insecticide, causes serious ill-effects in mammalian reproductive physiology. The present study aims at assessing malathion-induced toxicity in a dose- and time-dependent manner with mitigating effects of N-acetyl-l-cysteine. The testicular germ cell viability was monitored using MTT assay, where NAC, being an antioxidant significantly reduced malathion-induced toxicity by enhancing the frequency of cell viability. The histomorphological analysis showed that NAC successfully diminished several apoptotic features in testicular cells, induced by malathion...
February 19, 2018: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29457656/fatty-acid-binding-protein-deletion-prevents-stress-induced-preference-for-cocaine-and-dampens-stress-induced-corticosterone-levels
#6
John Hamilton, Matthew Marion, Antonio Figueiredo, Brendan H Clavin, Dale Deutsch, Martin Kaczocha, Samir Haj-Dahmane, Panayotis K Thanos
Genetic and pharmacological manipulation of endocannabinoid (eCB) signaling has previously been shown to have an important role on the rewarding properties of drugs of abuse, including cocaine. Recently, fatty acid binding proteins (FABPs) have been proposed as intracellular transporters of the endocannabinoid anandamide (AEA) as well as other bioactive lipids to their catabolic enzyme, fatty acid amide hydrolase (FAAH). The role of these transporters in modulating the brains reward system has yet to be investigated...
February 19, 2018: Synapse
https://www.readbyqxmd.com/read/29456507/the-effects-of-vitamin-d-supplementation-on-signaling-pathway-of-inflammation-and-oxidative-stress-in-diabetic-hemodialysis-a-randomized-double-blind-placebo-controlled-trial
#7
Hamed Haddad Kashani, Elahe Seyed Hosseini, Hossein Nikzad, Alireza Soleimani, Maryam Soleimani, Mohammad Reza Tamadon, Fariba Keneshlou, Zatollah Asemi
Objective: This study was carried out to determine the effects of vitamin D supplementation on signaling pathway of inflammation and oxidative stress in diabetic hemodialysis (HD) patients. Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 60 diabetic HD patients. Subjects were randomly allocated into two groups to intake either vitamin D supplements at a dosage of 50,000 IU ( n = 30) or placebo ( n = 30) every 2 weeks for 12 weeks. Gene expression of inflammatory cytokines and biomarkers of oxidative stress were assessed in peripheral blood mononuclear cells (PBMCs) of diabetic HD patients with RT-PCR method...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29456376/academic-stress-and-prevalence-of-stress-related-self-medication-among-undergraduate-female-students-of-health-and-non-health-cluster-colleges-of-a-public-sector-university-in-dammam-saudi-arabia
#8
Fatima Al Rasheed, Atta Abbas Naqvi, Rizwan Ahmad, Niyaz Ahmad
Objective: The objective was to report academic stress and prevalence of stress-related self-medication among undergraduate female students of health and nonhealth cluster colleges at a public sector university in Dammam, Saudi Arabia. Materials and Methods: A 5-month cross-sectional survey was conducted in the university. The survey included the English version of 10-item Perceived Stress Scale (PSS) to report self-perceived stress. Student responses were analyzed by SPSS version 22 software...
October 2017: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/29456203/effect-of-vitamin-e-on-reversibility-of-renal-function-following-discontinuation-of-colistin-in-rats-histological-and-biochemical-investigations
#9
Zohra Ghlissi, Ahmed Hakim, Hela Mnif, Rim Kallel, Khaled Zeghal, Tahiya Boudawara, Zouheir Sahnoun
This study was carried out to evaluate spontaneous renal regeneration after stopping colistin methanesulfonate (CMS), which induces tubular damage, and the curative effect of Vitamin E (vit E) in rats. Animals were given the following: sterile saline (n = 6), 300,000 IU/kg/ day of CMS (n = 24), or 450,000 IU/kg/day of CMS (n = 24) for seven days. Each CMS group was subdivided into four subgroups (n = 6) and sacrificed as follows: (i) 12 h after stopping CMS, (ii) two weeks after stopping CMS, (iii) two weeks after stopping treatment with vit E, and (iv) two weeks after stopping treatment with olive oil...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456159/cd150-high-bone-marrow-tregs-maintain-hematopoietic-stem-cell-quiescence-and-immune-privilege-via-adenosine
#10
Yuichi Hirata, Kazuhiro Furuhashi, Hiroshi Ishii, Hao Wei Li, Sandra Pinho, Lei Ding, Simon C Robson, Paul S Frenette, Joji Fujisaki
A crucial player in immune regulation, FoxP3+ regulatory T cells (Tregs) are drawing attention for their heterogeneity and noncanonical functions. Here, we describe a Treg subpopulation that controls hematopoietic stem cell (HSC) quiescence and engraftment. These Tregs highly expressed an HSC marker, CD150, and localized within the HSC niche in the bone marrow (BM). Specific reduction of BM Tregs achieved by conditional deletion of CXCR4 in Tregs increased HSC numbers in the BM. Adenosine generated via the CD39 cell surface ectoenzyme on niche Tregs protected HSCs from oxidative stress and maintained HSC quiescence...
February 7, 2018: Cell Stem Cell
https://www.readbyqxmd.com/read/29455546/effects-of-complete-water-fasting-and-regeneration-diet-on-kidney-function-oxidative-stress-and-antioxidants
#11
V Mojto, A Gvozdjakova, J Kucharska, Z Rausova, O Vancova, J Valuch
OBJECTIVE: The aim of the study was to observe the influence of 11-days complete water fasting (WF) and regeneration diet (RD) on renal function, body weight, blood pressure and oxidative stress. BACKGROUND: Therapeutic WF is considered a healing method. METHODS: Ten volunteers drank only water for 11 days, followed by RD for the next 11 days. Data on body weight, blood pressure, kidney functions, antioxidants, lipid peroxidation, cholesterols, triacylglycerols and selected biochemical parameters were obtained...
2018: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/29455384/novel-interventions-to-reduce-stress-and-overeating-in-overweight-pregnant-women-a-feasibility-study
#12
B A Laraia, N E Adler, K Coleman-Phox, C Vieten, L Mellin, J L Kristeller, M Thomas, N E Stotland, R H Lustig, M F Dallman, F M Hecht, N R Bush, C L de Groat, E Epel
Background High stress and depression during pregnancy are risk factors for worsened health trajectories for both mother and offspring. This is also true for pre-pregnancy obesity and excessive gestational weight gain. Reducing stress and depression may be one path to prevent excessive caloric intake and gestational weight gain. Study Purpose We tested the feasibility of two novel interventions aimed at reducing stress and overeating during pregnancy. Reflecting different theoretical underpinnings, the interventions target different mechanisms...
February 17, 2018: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29454967/sarm1-deletion-restrains-nafld-induced-by-high-fat-diet-hfd-through-reducing-inflammation-oxidative-stress-and-lipid-accumulation
#13
Zhen-Guo Pan, Xu-Sheng An
SARM1 (Sterile alpha and armadillo motif-containing protein 1) is the recently identified TIR domain-containing cytosolic protein, which is involved in toll-like receptors (TLRs) signaling transduction. In the present study, the role of SARM1 in high fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) progression was explored. We found that SARM1 was expressed highly in fatty liver. And SARM1-knockout (KO) reduced steatohepatitis and metabolic disorders induced by HFD. SARM1-deletion decreased aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in HFD-fed mice...
February 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29454923/seasonal-differences-in-the-content-of-phenols-and-pigments-in-thalli-of-freshwater-cladophora-glomerata-and-its-habitat
#14
Joanna Fabrowska, Beata Messyasz, Radosław Pankiewicz, Patrycja Wilińska, Bogusława Łęska
Polyphenols are chemicals that primarily inhibit the growth of various autotrophic organisms. The presence of these metabolites greatly boosts the ecological dominance of eg. Cladophora, which creates large surface mats. The main goal of our work was to quantify the phenol and polyphenols (allelopathic substances) secreted by the macroalgae as a result of exposure to biotic stress caused by competition. The research was carried out on the Cladophora glomerata biomass collected from two freshwater ecosystems located in Wielkopolska Region (Poland, Fig...
February 10, 2018: Water Research
https://www.readbyqxmd.com/read/29454627/changes-in-salsolinol-production-and-salsolinol-synthase-activity-in-parkinson-s-disease-model
#15
Xiaotong Zheng, Xuechai Chen, Minjun Guo, Sakhawat Ali, Yinghui Huang, Feiyi Sun, Kefu Liu, Zixuan Chen, Yulin Deng, Rugang Zhong
Salsolinol is an endogenous neurotoxin derived from dopamine, and has been proved to cause the apoptosis of the dopaminergic neurons involved in the pathogenesis of Parkinson's disease (PD). Salsolinol synthase is the key enzyme in the biosynthesis of salsolinol, and its activity exists in most regions of rat brain. However, the activity distribution and its catalyzed function in vivo are still unknown. On the basis of the chromatographic assay established previously, we investigated the activity of salsolinol synthase and salsolinol production in both cell and rat model of PD induced by 6-hydroxydopamine (6-OHDA)...
February 15, 2018: Neuroscience Letters
https://www.readbyqxmd.com/read/29454609/deubiquitinase-inhibitor-b-ap15-activates-endoplasmic-reticulum-er-stress-and-inhibits-wnt-notch1-signaling-pathway-leading-to-the-reduction-of-cell-survival-in-hepatocellular-carcinoma-cells
#16
Youming Ding, Xiaoyan Chen, Bin Wang, Bin Yu, Jianhui Ge
b-AP15, a potent and selective inhibitor of the ubiquitin-specific peptidase 14 (USP14), displays in vitro and in vivo antitumor abilities on some types of cancer cells. However, the mechanism underlying its action is not well elucidated. The purposes of the present study are to observe the potential impacts of b-AP15 on cell survival of hepatocellular carcinoma cells and to investigate whether and how this compound inhibits some survival-promoting signaling pathways. We found that b-AP15 significantly decreased cell viability and increased cell apoptosis in a dose-dependent manner in hepatocellular carcinoma cells, along with the perturbation of cell cycle and the decreased expressions of cell cycle-related proteins...
February 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29454169/farmyard-manure-alone-and-combined-with-immobilizing-amendments-reduced-cadmium-accumulation-in-wheat-and-rice-grains-grown-in-field-irrigated-with-raw-effluents
#17
Muhammad Zia Ur Rehman, Muhammad Rizwan, Hinnan Khalid, Shafaqat Ali, Asif Naeem, Balal Yousaf, Guijian Liu, Muhammad Sabir, Muhammad Farooq
Cadmium (Cd) stress is a serious concern in agricultural soils worldwide whereas little is known about the impact of farmyard manure (FYM) alone or combined with limestone, lignite and biochar on Cd concentrations in plants. Wheat was grown in Cd-contaminated field amended with control (T 1 ), FYM @ 0.1% (T 2 ), FYM + limestone @ 0.05% each (T 3 ), FYM + lignite @ 0.05% each (T 4 ), FYM + biochar @ 0.05% each (T 5 ) and subsequent rice was grown without additional use of amendments. Soil application of amendments increased straw and grain yield and thousand grain weight being maximum in FYM + limestone treatment...
February 8, 2018: Chemosphere
https://www.readbyqxmd.com/read/29453605/enhanced-recovery-after-surgery-eras-principles-practice-and-feasibility-in-the-elderly
#18
Olle Ljungqvist, Martin Hubner
This is a short overview of the principles of a novel development in surgery called enhanced recovery after surgery (ERAS) programs. This is an evidence-based approach to perioperative care that has shown to reduce complications and recovery time by 30-50%. The main mechanism is reduction of the stress reactions to the operation. These principles have been shown to be particularly well suited for the compromised patient and hence very good for the elderly people who often have co-morbidities and run a higher risk of complications...
February 16, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29453255/endophyte-mediated-modulation-of-defense-responsive-genes-and-systemic-resistance-in-withania-somnifera-l-dunal-under-alternaria-alternata-stress
#19
Aradhana Mishra, Satyendra Pratap Singh, Sahil Mahfooz, Surendra Pratap Singh, Arpita Bhattacharya, Nishtha Mishra, C S Nautiyal
Endophytes have been explored to perform an important role in plant health. However, their effects on the host physiological function and disease management remains elusive. The present study was aimed to assess the potential of endophytes singly as well as in combination on various physiological parameters and systemic defense mechanism against Alternaria alternata in Withania somnifera (L.) Dunal. Seed priming with endophytic Bacillus amyloliquefaciens and Pseudomonas fluorescens individually and in combination demonstrated enhanced vigor index and germination rate...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29452888/could-low-protein-diet-modulate-nrf2-pathway-in-chronic-kidney-disease
#20
REVIEW
Juliana Saraiva Anjos, Ludmila F M F Cardozo, Marta Esgalhado, Bengt Lindholm, Peter Stenvinkel, Denis Fouque, Denise Mafra
Oxidative stress and inflammation are common findings in chronic kidney disease (CKD) patients, and they are directly linked to clinical outcomes such as protein energy wasting and cardiovascular disease. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is the master regulator of antioxidant genes, regulating the expression of detoxifying enzymes of phase II and antioxidant responses. Furthermore, Nrf2 can also regulate anti-inflammatory cellular responses, by inhibiting nuclear factor kappa B activity (transcription factor that promotes inflammation)...
February 13, 2018: Journal of Renal Nutrition
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