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https://www.readbyqxmd.com/read/29679934/nanopriming-with-zero-valent-iron-nzvi-enhances-germination-and-growth-in-aromatic-rice-cultivar-oryza-sativa-cv-gobindabhog-l
#1
Titir Guha, K V G Ravikumar, Amitava Mukherjee, Anita Mukherjee, Rita Kundu
Engineered nanoparticles are utilized in agriculture for various purposes. They can be used as fertilizer, carrier for macro/micro nutrients or priming agents. Various nanoparticles are reported to have toxicity at very high doses, but at optimum concentration, they can be beneficial for plant growth and development. In the present study, low concentrations of nZVI nanoparticles were evaluated for their growth enhancement potential as seed priming agent in an aromatic rice cultivar, Oryza sativa cv. Gobindabhog...
April 12, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29679855/rutin-and-rutin-conjugated-gold-nanoparticles-ameliorate-collagen-induced-arthritis-in-rats-through-inhibition-of-nf-%C3%AE%C2%BAb-and-inos-activation
#2
Anum Gul, Bimal Kunwar, Maryam Mazhar, Shaheen Faizi, Dania Ahmed, Muhammad Raza Shah, Shabana U Simjee
Numerous studies have suggested that nuclear factor-κB (NF-κB) and inducible nitric oxide synthase (iNOS) are important mediators of inflammatory response in human and animal models of arthritis. Besides, oxidative stress markers, nitric oxide (NO) and peroxide (PO) are also major contributors in the pathogenesis of rheumatoid arthritis (RA). Over expression of these inflammatory mediators leads to the extracellular matrix degradation, and excessive cartilage and bone resorption, ultimately leading to the irreversible damage to joints...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679158/de-implementation-of-urodynamics-in-the-netherlands-after-the-value-vusis-2-results-a-nationwide-survey
#3
Bianca B Mengerink, Willianne L D M Nelen, Sanne A L van Leijsen, John P F A Heesakkers, Kirsten B Kluivers
INTRODUCTION AND HYPOTHESIS: We aimed to estimate the level of de-implementation of preoperative routine urodynamics (UDS) before stress urinary incontinence (SUI) surgery in The Netherlands and to analyze facilitators and barriers. Routine UDS was performed by 37% of the medical specialists in 2010. We hypothesized that the recommendations from the recent Value of Urodynamics prior to Stress Incontinence Surgery (VUSIS) and Value of Urodynamic Evaluation (ValUE) studies would have been followed by a reduction of routine UDS...
April 20, 2018: International Urogynecology Journal
https://www.readbyqxmd.com/read/29679123/-wide-awake-hand-surgery-based-on-application-examples
#4
P Kaiser, M Keller, J Dörler, G Schmidle
OBJECTIVE: Anesthesiologic method with low bleeding level, risk level, and complication rate for surgical procedures on the hand without a tourniquet on an unsedated patient with the possibility for functional testing during surgery. INDICATIONS: Surgical procedures of the hand can be carried out using the wide awake technique depending on the patient's suitability and preference considering individual risk factors. CONTRAINDICATIONS: Absolute contraindications are allergies to the local anesthetic or its components...
April 20, 2018: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/29678550/low-level-shear-stress-promotes-migration-of-liver-cancer-stem-cells-via-the-fak-erk1-2-signalling-pathway
#5
Jinghui Sun, Qing Luo, Lingling Liu, Guanbin Song
Cancer stem cells (CSCs) are a small subpopulation of tumour cells that have been proposed to be responsible for cancer initiation, chemotherapy resistance and cancer recurrence. Shear stress activated cellular signalling is involved in cellular migration, proliferation and differentiation. However, little is known about the effects of shear stress on the migration of liver cancer stem cells (LCSCs). Here, we studied the effects of shear stress that are generated from a parallel plated flow chamber system, on LCSC migration and the activation of focal adhesion kinase (FAK) and extracellular signal regulated kinase1/2 (ERK1/2), using transwell assay and western blot, respectively...
April 17, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29677709/reliability-improvement-in-solution-processed-zro%C3%A2-dielectrics-due-to-addition-of-h%C3%A2-o%C3%A2
#6
Minsoo Kim, Pyungho Choi, Jeonghyun Lee, Kiwon Lim, Younghwan Hyeon, Kwangjun Koo, Byoungdeog Choi
In this study, we investigated the effects of hydrogen peroxide (H2O2) on solution-processed zirconium oxide (ZrO2) dielectric materials. The addition of H2O2 into ZrO2 dielectric showed a reduction in hysteresis capacitance-voltage characteristics (from 393 mV to 96 mV). This resulted in a reduction in border trap density (Nbt) of the ZrO2 film (ZrO2: 2.24 × 1011 cm-2, ZrO2 + H2O2: 3.96 × 1010 cm-2). In addition, use of H2O2 in the ZrO2 dielectric improved the interface quality. Specifically, the reduced number of trap sites improved the reliability of the device under a negative bias stress (NBS)...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677606/5-hz-repetitive-transcranial-magnetic-stimulation-for-posttraumatic-stress-disorder-comorbid-with-major-depressive-disorder
#7
Linda L Carpenter, Christine Conelea, Audrey R Tyrka, Emma S Welch, Benjamin D Greenberg, Lawrence H Price, Matthew Niedzwiecki, Agustin G Yip, Jennifer Barnes, Noah S Philip
BACKGROUND: Standard clinical protocols for repetitive transcranial magnetic stimulation (rTMS) for major depressive disorder (MDD) apply 10 Hz pulses over left prefrontal cortex, yet little is known about the effects of rTMS in more diagnostically complex depressed patients. OBJECTIVE/HYPOTHESIS: Posttraumatic stress disorder (PTSD) is commonly comorbid with MDD, and while rTMS has been shown to alleviate PTSD symptoms in preliminary studies, ideal parameters remain unclear...
April 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29677453/l-carnitine-induced-amelioration-of-hdf-induced-hepatic-dysfunction-is-accompanied-by-a-reduction-in-hepatic-tnf-%C3%AE-and-tgf%C3%AE-1
#8
Mabrouk Attia Abd Eldaim, Fatma Mohamed Ibrahim, Sahar H Orabi, Azza Hassan Morsi, Hesham Saad ElSabbagh
In this study the possible mechanisms through which L-carnitine ameliorates the adverse effects of high fat diet (HFD) induced obesity on rats was evaluated. 56 Wister albino rats were randomly assigned into seven groups. Control rats fed basal diet. 2nd group fed basal diet and injected with L-carnitine 200 mg/kg i.p. 3rd group fed HFD. 4th group fed HFD and injected with L-Carnitine 200 mg/kg i.p for 8 weeks. 5th group fed HFD for 10 weeks. 6th group fed HFD for 10 weeks and injected with L-Carnitine 200 mg/kg i...
April 20, 2018: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29677398/does-stress-increase-risk-of-breast-cancer-a-15-year-prospective-study
#9
Phyllis Butow, Melanie Price, Joseph Coll, Katherine Tucker, Bettina Meiser, Roger Milne, Judith Wilson, Louise Heiniger, Brandi Baylock, Tracey Bullen, Prue Weideman, Kelly-Anne Phillips
OBJECTIVE: The possible impact of stress on cancer incidence remains controversial. We prospectively evaluated associations between life event stressors, social support, personality characteristics (optimism, anger control, anti-emotionality) and risk of developing primary breast cancer (BCa), in women at increased familial risk of BCa. METHODS: A prospective cohort, repeated measures design was employed. Recruitment was through the Kathleen Cuningham Foundation Consortium for Research into Familial breast cancer (kConFab), which collects genetic, epidemiological and clinical data from Australasian families with multiple BCa cases...
April 20, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29677344/interaction-between-pilocarpine-and-ripasudil-on-intraocular-pressure-pupil-diameter-and-the-aqueous-outflow-pathway
#10
Reiko Yamagishi-Kimura, Megumi Honjo, Takashi Komizo, Takashi Ono, Akiko Yagi, Jinhee Lee, Kazunori Miyata, Tomokazu Fujimoto, Toshihiro Inoue, Hidenobu Tanihara, Junko Nishida, Takatoshi Uchida, Yuka Araki, Makoto Aihara
Purpose: To explore interactions between pilocarpine and the ROCK inhibitor, ripasudil, on IOP and pupil diameter in human eyes, and morphological and functional changes in outflow tissues in vitro. Methods: IOP and pupil diameter were measured after pilocarpine and/or ripasudil, which were topically applied in healthy subjects. Human trabecular meshwork (HTM) cells were used in a gel contraction assay, for the evaluation of phosphorylation of myosin light chain and cofilin, and immunostaining for cytoskeletal proteins...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677158/reformulation-as-an-integrated-approach-of-four-disciplines-a-qualitative-study-with-food-companies
#11
Annelies van Gunst, Annet J C Roodenburg, Ingrid H M Steenhuis
In 2014, the Dutch government agreed with the food sector to lower salt, sugar, saturated fat and energy in foods. To reformulate, an integrated approach of four disciplines (Nutrition & Health, Food Technology, Legislation, and Consumer Perspectives) is important for food companies (Framework for Reformulation). The objective of this study was to determine whether this framework accurately reflects reformulation processes in food companies. Seventeen Dutch food companies in the bakery, meat and convenience sector were interviewed with a semi-structured topic list...
April 20, 2018: Foods (Basel, Switzerland)
https://www.readbyqxmd.com/read/29676857/proteomics-analysis-reveals-abnormal-electron-transport-and-excessive-oxidative-stress-cause-mitochondrial-dysfunction-in-placental-tissues-of-early-onset-preeclampsia
#12
Zhongwei Xu, Xiaohan Jin, Wei Cai, Maobin Zhou, Ping Shao, Zhen Yang, Rong Fu, Jin Cao, Yan Liu, Fang Yu, Rong Fan, Yan Zhang, Shuang Zou, Xin Zhou, Ning Yang, Xu Chen, Yuming Li
PURPOSE: Early-onset preeclampsia (EOS-PE) refers to preeclampsia that occurred before 34 gestation weeks. This study was conducted to explore the relationship between mitochondrial dysfunction and the pathogenesis of EOS-PE using proteomic strategy. EXPERIMENTAL DESIGN: To identify altering expressed mitochondrial proteins between severe EOS-PE and healthy pregnancies, enrichment of mitochondria coupled with iTRAQ-based quantitative proteomic method was performed...
April 20, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29675530/hepatoprotective-activity-of-iridoids-seco-iridoids-and-analog-glycosides-from-gentianaceae-on-hepg2-cells-via-cyp3a4-induction-and-mitochondrial-pathway
#13
Kang Dai, Xue-Jia Yi, Xian-Ju Huang, Azhar Muhammad, Mei Li, Jun Li, Guang-Zhong Yang, Yue Gao
Gentianaceae herb extracts have been widely used as food additives, teas or medicinal remedies for various diseases and disorders of the human body. Herein, the potential effects of iridoids, seco-iridoids and analog glycosides from gentian on acontine-induced hepatotoxicity were investigated in HepG2 cells to obtain metabolic data of drug-biotarget interactions. Molecular docking analysis was performed to assess the binding efficiencies of 53 iridoids, seco-iridoids and analog compounds obtained from 50 gentian species to the active sites of human CYP3A4 enzyme...
April 20, 2018: Food & Function
https://www.readbyqxmd.com/read/29675133/benefit-of-oleuropein-aglycone-for-alzheimer-s-disease-by-promoting-autophagy
#14
REVIEW
Joaquín G Cordero, Ramón García-Escudero, Jesús Avila, Ricardo Gargini, Vega García-Escudero
Alzheimer's disease is a proteinopathy characterized by accumulation of hyperphosphorylated Tau and β -amyloid. Autophagy is a physiological process by which aggregated proteins and damaged organelles are eliminated through lysosomal digestion. Autophagy deficiency has been demonstrated in Alzheimer's patients impairing effective elimination of aggregates and damaged mitochondria, leading to their accumulation, increasing their toxicity and oxidative stress. In the present study, we demonstrated by microarray analysis the downregulation of fundamental autophagy and mitophagy pathways in Alzheimer's patients...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29675028/the-apoplastic-secretome-of-trichoderma-virens-during-interaction-with-maize-roots-shows-an-inhibition-of-plant-defence-and-scavenging-oxidative-stress-secreted-proteins
#15
Guillermo Nogueira-Lopez, David R Greenwood, Martin Middleditch, Christopher Winefield, Carla Eaton, Johanna M Steyaert, Artemio Mendoza-Mendoza
In Nature, almost every plant is colonized by fungi. Trichoderma virens is a biocontrol fungus which has the capacity to behave as an opportunistic plant endophyte. Even though many plants are colonized by this symbiont, the exact mechanisms by which Trichoderma masks its entrance into its plant host remain unknown, but likely involve the secretion of different families of proteins into the apoplast that may play crucial roles in the suppression of plant immune responses. In this study, we investigated T. virens colonization of maize roots under hydroponic conditions, evidencing inter- and intracellular colonization by the fungus and modifications in root morphology and coloration...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29674951/integrating-genetic-and-gene-co-expression-analysis-identifies-gene-networks-involved-in-alcohol-and-stress-responses
#16
Jie Luo, Pei Xu, Peijian Cao, Hongjian Wan, Xiaonan Lv, Shengchun Xu, Gangjun Wang, Melloni N Cook, Byron C Jones, Lu Lu, Xusheng Wang
Although the link between stress and alcohol is well recognized, the underlying mechanisms of how they interplay at the molecular level remain unclear. The purpose of this study is to identify molecular networks underlying the effects of alcohol and stress responses, as well as their interaction on anxiety behaviors in the hippocampus of mice using a systems genetics approach. Here, we applied a gene co-expression network approach to transcriptomes of 41 BXD mouse strains under four conditions: stress, alcohol, stress-induced alcohol and control...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29672271/anti-ulcerogenic-effect-of-the-methanol-extract-of-chasmanthera-dependens-hochst-stem-on-male-wistar-rats
#17
Stephanie Abiola Tijani, Samuel B Olaleye, Ebenezer O Farombi
BACKGROUND: Oxidative stress and free radical-mediated processes have been implicated in the pathogenesis of indomethacin-induced gastric ulcer. This study investigated the ability of the methanol extract of Chasmanthera dependens to protect the gastric mucosal from oxidative damage induced by oral administration of indomethacin in rats. METHODS: The C. dependens stems were chopped into pieces, air-dried, and pulverized into powder. One kilogram of the powder was macerated in 1 L of methanol for 72 h...
April 19, 2018: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/29671210/indian-ginseng-withania-somnifera-supplementation-ameliorates-oxidative-stress-and-mitochondrial-dysfunctions-in-experimental-model-of-stroke
#18
Abhilasha Sood, Arpit Mehrotra, Devinder K Dhawan, Rajat Sandhir
Stroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential of Indian Ginseng, also known as Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimental model of ischemic stroke. Stroke was induced in animals by occluding the middle cerebral artery, followed by reperfusion injury. Ischemia reperfusion injury resulted in increased oxidative stress indicated by increased reactive oxygen species and protein carbonyl levels; compromised antioxidant system; in terms of reduced superoxide dismutase and catalase activity, along with reduction in GSH levels and the redox ratio, impaired mitochondrial functions and enhanced expression of apoptosis markers...
April 18, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29671020/luteolin-alleviates-cardiac-ischemia-reperfusion-injury-in-the-hypercholesterolemic-rat-via-activating-akt-nrf2-signaling
#19
Jin-Ting Yang, Jue Wang, Xin-Ru Zhou, Chi Xiao, Yang-Yun Lou, Li-Hui Tang, Feng-Jiang Zhang, Ling-Bo Qian
Myocardial ischemia/reperfusion (I/R) injury in hypercholesterolemia is associated with oxidative stress, while luteolin is known to reduce oxidative stress by activating Akt/nuclear factor erythroid-2-related factor 2 (Nrf2) signaling and alleviate cardiac I/R injury. Here, we investigated whether luteolin pretreatment diminishes myocardial I/R injury in hypercholesterolemic rats by activating Akt/Nrf2 signaling. Hypercholesterolemic rats were produced by 2% cholesterol diet for 8 weeks. Luteolin (100 mg/kg/day, i...
April 18, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29670534/divergent-mitochondrial-antioxidant-activities-and-lung-alveolar-architecture-in-the-lungs-of-rats-and-mice-at-high-altitude
#20
Alexandra Jochmans-Lemoine, Susana Revollo, Gabriella Villalpando, Ibana Valverde, Marcelino Gonzales, Sofien Laouafa, Jorge Soliz, Vincent Joseph
Compared with mice, adult rats living at 3,600 m above sea level (SL-La Paz, Bolivia) have high hematocrit, signs of pulmonary hypertension, and low lung volume with reduced alveolar surface area. This phenotype is associated with chronic mountain sickness in humans living at high altitude (HA). We tested the hypothesis that this phenotype is associated with impaired gas exchange and oxidative stress in the lungs. We used rats and mice (3 months old) living at HA (La Paz) and SL (Quebec City, Canada) to measure arterial oxygen saturation under graded levels of hypoxia (by pulse oximetry), the alveolar surface area in lung slices and the activity of pro- (NADPH and xanthine oxidases-NOX and XO) and anti- (superoxide dismutase, and glutathione peroxidase-SOD and GPx) oxidant enzymes in cytosolic and mitochondrial lung protein extracts...
2018: Frontiers in Physiology
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