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https://www.readbyqxmd.com/read/29050412/adaptive-response-to-exercise-of-fast-growing-and-slow-growing-chicken-strains-blood-oxidative-status-and-non-enzymatic-antioxidant-defense
#1
S Mattioli, A Dal Bosco, S Ruggeri, M Martino, L Moscati, C Pesca, C Castellini
The adaptation of chickens to free-range rearing systems mainly involves the locomotory behavior, which is very different in fast-growing (FG) and slow-growing (SG) strains. This study aimed to compare the effect of moderate locomotory activity (induced and prolonged) on the blood oxidative status in a slow-growing chicken strain with that in a fast-growing one. Thirty FG (Ross 308) birds and 30 SG (Hubbard) birds were divided into 2 groups for each strain and subjected to different treatments: no exercise (the control group [C]) and 1 h of walking at 4 km/h (the exercise group [E])...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29050406/microbiological-quality-assessment-and-validation-of-antimicrobials-against-unstressed-or-cold-stress-adapted-salmonella-and-surrogate-enterococcus-faecium-on-broiler-carcasses-and-wings
#2
Lacey Lemonakis, KaWang Li, Jeremy M Adler, Cangliang Shen
This study aims to evaluate the microbiological quality and efficacy of antimicrobials to inactivate unstressed or cold-stress adapted Salmonella and Enterococcus on broiler carcasses and wings processed at a small USDA-inspected slaughter facility in West Virginia. The first part of the study included 42 carcasses that were pre- and secondarily-enriched in bacterial media followed by streak-plating onto XLT-4 and HardyCHROM™-agar Salmonella and confirmation using an API20E-kit. The aerobic plate counts (APC), Escherichia coli (ECC), total coliforms (TCC), and yeast/molds were analyzed on petri-films...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/29049923/attenuation-of-heat-stress-induced-spermatogenesis-complications-by-betaine-in-mice
#3
Somayeh Shadmehr, Seyed Reza Fatemi Tabatabaei, Shima Hosseinifar, Mohammad Reza Tabandeh, Alireza Amiri
High temperatures can induce oxidative stress, impairment of spermatogenesis, and reduction of sperm quality and quantity concomitant with transient periods of partial or complete infertility in male mammals. Promising beneficial effects of betaine supplementation on the epididymal spermatozoa have been reported in experimental studies; however, its effects on testicular heat stress (HS)-induced impairment have yet to be determined. In the present study, betaine (Bet) was orally administrated (250 mg/kg day) during a 14-day period, before (Bet + HS group) or after (HS + Bet group) induction of testicular HS in 7-9 week-old male mice...
October 7, 2017: Theriogenology
https://www.readbyqxmd.com/read/29049902/emotion-dysregulation-moderates-the-effect-of-cognitive-behavior-therapy-with-prolonged-exposure-for-co-occurring-ptsd-and-substance-use-disorders
#4
Denise A Hien, Teresa Lopez-Castro, Santiago Papini, Bernard Gorman, Lesia M Ruglass
A goal of clinical trials is to identify unique baseline characteristics that can inform treatment planning. One such target is emotion dysregulation (ED), which contributes to the maintenance of co-occurring posttraumatic stress disorder (PTSD) and substance use disorder (SUD) and may be a potential moderator of treatment response. We examined the moderating impact of ED severity on treatment outcomes in an urban, socioeconomically disadvantaged, and racially/ethnically diverse sample with complex trauma and severe SUDs...
October 16, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29049901/the-efficacy-of-aerobic-exercise-and-resistance-training-as-transdiagnostic-interventions-for-anxiety-related-disorders-and-constructs-a-randomized-controlled-trial
#5
Daniel M LeBouthillier, Gordon J G Asmundson
Evidence supports exercise as an intervention for many mental health concerns; however, randomized controlled investigations of the efficacy of different exercise modalities and predictors of change are lacking. The purposes of the current trial were to: (1) quantify the effects of aerobic exercise and resistance training on anxiety-related disorder (including anxiety disorders, obsessive-compulsive disorder, and posttraumatic stress disorder) status, symptoms, and constructs, (2) evaluate whether both modalities of exercise were equivalent, and (3) to determine whether exercise enjoyment and physical fitness are associated with symptom reduction...
September 23, 2017: Journal of Anxiety Disorders
https://www.readbyqxmd.com/read/29049348/chronic-administration-of-fluoxetine-and-pro-inflammatory-cytokine-change-in-a-rat-model-of-depression
#6
Yanxia Lu, Cyrus S Ho, Xin Liu, Anna N Chua, Wei Wang, Roger S McIntyre, Roger C Ho
This study evaluated the chronic effects of fluoxetine, a commonly prescribed SSRI antidepressant, on the peripheral and central levels of inflammatory cytokines including IL-1β, IL-6, TNF-α and IL-17 over a 4-interval in a rat model of chronic mild stress (CMS) which resembles the human experience of depression. Twenty-four Sprague-Dawley rats were randomly assigned to CMS+vehicle (n = 9), CMS+fluoxetine (n = 9) and the control (n = 6) groups. Sucrose preference and forced swim tests were performed to assess behavioral change...
2017: PloS One
https://www.readbyqxmd.com/read/29048234/parent-education-for-young-children-with-autism-and-disruptive-behavior-response-to-active-control-treatment
#7
Jessica Bradshaw, Karen Bearss, Courtney McCracken, Tristram Smith, Cynthia Johnson, Luc Lecavalier, Naomi Swiezy, Lawrence Scahill
This study examines parent and child characteristics in young children with autism spectrum disorder and disruptive behavior who showed a positive response to a parent education program in a randomized clinical trial of parent training. Children with autism spectrum disorder (N = 180) were randomized to parent training (PT) or parent education program (PEP) for 6 months. Using the Clinical Global Impression-Improvement scale, masked independent evaluators rated positive response in 68.5% of children in PT compared to 39...
October 19, 2017: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29047099/techniques-for-detecting-reactive-oxygen-species-in-pulmonary-vasculature-redox-signaling
#8
Yi Xu, Steven Qian
Redox signaling plays important roles in regulating pulmonary vasculature function. Aberrant redox signaling, e.g., overproduction of reactive oxygen species (ROS) that exceeds the capability of cellular antioxidant mechanisms, has been found to alter vasculature function and remodel blood vessel structure, thus contributes to pathological processes of pulmonary vasculature. The regulation of pulmonary vasculature via ROS is a very complicated process with various biological events involved, however, the specific effect of individual ROS and the underlying mechanism still remain unclear...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29046782/assessment-of-the-potential-for-resistance-to-antimicrobial-violet-blue-light-in-staphylococcus-aureus
#9
Rachael M Tomb, Michelle Maclean, John E Coia, Scott J MacGregor, John G Anderson
BACKGROUND: Antimicrobial violet-blue light in the region of 405 nm is emerging as an alternative technology for hospital decontamination and clinical treatment. The mechanism of action is the excitation of endogenous porphyrins within exposed microorganisms, resulting in ROS generation, oxidative damage and cell death. Although resistance to 405 nm light is not thought likely, little evidence has been published to support this. This study was designed to establish if there is potential for tolerance development, using the nosocomial pathogen Staphylococcus aureus as the model organism...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29046732/effect-of-a-diet-containing-folate-and-hazelnut-oil-capsule-on-the-methylation-level-of-the-adrb3-gene-lipid-profile-and-oxidative-stress-in-overweight-or-obese-women
#10
Raquel Patrícia Ataíde Lima, Rayner Anderson Ferreira do Nascimento, Rafaella Cristhine Pordeus Luna, Darlene Camati Persuhn, Alexandre Sérgio da Silva, Maria da Conceição Rodrigues Gonçalves, Alessio Tony Cavalcanti de Almeida, Ronei Marcos de Moraes, Eliseu Verly Junior, Emmanuelle Fouilloux-Meugnier, Hubert Vidal, Luciano Pirola, Marciane Magnani, Naila Francis Paulo de Oliveira, Patrícia Oliveira Prada, Maria José de Carvalho Costa
BACKGROUND: Studies of genes that play an important role in the development of obesity are needed, especially studies focusing on genes that regulate food intake and affect nutrient metabolism. For example, the beta-3 adrenergic receptor (ADRB3) responds to noradrenaline and mediates lipolysis in adipocytes. METHODS: This was a controlled intervention study involving 40 overweight and obese adult women in which food intake, anthropometric measurements, biochemical analyses, and methylation levels of the ADRB3 gene were evaluated before and after intervention...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29046700/cerebral-ischemic-injury-decreases-%C3%AE-synuclein-expression-in-brain-tissue-and-glutamate-exposed-ht22-cells
#11
Phil-Ok Koh
α-Synuclein is abundantly expressed in neuronal tissue, plays an essential role in the pathogenesis of neurodegenerative disorders, and exerts a neuroprotective effect against oxidative stress. Cerebral ischemia causes severe neurological disorders and neuronal dysfunction. In this study, we examined α-synuclein expression in middle cerebral artery occlusion (MCAO)-induced cerebral ischemic injury and neuronal cells damaged by glutamate treatment. MCAO surgical operation was performed on male Sprague-Dawley rats, and brain samples were isolated 24 hours after MCAO...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046437/modulation-of-global-transcriptional-regulatory-networks-as-a-strategy-for-increasing-kanamycin-resistance-of-the-translational-elongation-factor-g-mutants-in-escherichia-coli
#12
Aalap Mogre, Reshma T V, Aswin Sai Narain Seshasayee
Evolve and resequence experiments have provided us a tool to understand bacterial adaptation to antibiotics. In our previous work, we had used short term evolution to isolate mutants resistant to the ribosome targeting antibiotic kanamycin, and reported that Escherichia coli develops low cost resistance to kanamycin via  different point mutations in the translation Elongation Factor-G (EF-G). Furthermore, we had shown that the resistance of EF-G mutants could be increased by second site mutations in the genes rpoD / cpxA / topA / cyaA Mutations in three of these genes had been discovered in earlier screens for aminoglycoside resistance...
October 18, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29046340/nnt-is-a-key-regulator-of-adrenal-redox-homeostasis-and-steroidogenesis-in-male-mice
#13
Eirini Meimaridou, Michelle Goldsworthy, Vasileios Chortis, Ersi Fragouli, Paul A Foster, Wiebke Arlt, Roger Cox, Louise A Metherell
Nicotinamide nucleotide transhydrogenase, NNT, is a ubiquitous protein of the inner mitochondrial membrane with a key role in mitochondrial redox balance. NNT produces high concentrations of NADPH for detoxification of reactive oxygen species by glutathione and thioredoxin pathways. In humans, NNT dysfunction leads to an adrenal specific disorder, glucocorticoid deficiency. Certain sub-strains of C57BL/6 mice contain a spontaneously occurring inactivating Nnt mutation and display glucocorticoid deficiency along with glucose intolerance and reduced insulin secretion...
October 18, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/29045922/the-impact-of-expired-commercial-drugs-on-non-target-marine-species-a-case-study-with-the-use-of-a-battery-of-biomarkers-in-hemocytes-of-mussels
#14
Nektarios Politakis, Alexia Belavgeni, Ioanna Efthimiou, Nikolina Charalampous, Chara Kourkouta, Stefanos Dailianis
The present study investigated the effects of two expired commercial medicines, like Buscopan Plus and Mesulid, commonly classified as household medical wastes, on hemocytes of mussel Mytilus galloprovincialis. Mussel hemocytes' lysosomal membrane stability (in terms of neutral red retention assay), superoxide anions (O2(·)(-)) and nitric oxides (NO, in terms of nitrites) production, lipid peroxidation (in terms of malondialdehyde/MDA content) and the formation of nuclear abnormalities (using the micronucleus/MN assay) were assessed in hemocytes of mussels treated for 7 days with appropriate amounts of each drug (the concentrations of active substances were considered in each case, due to the absence of data related with the excipients) as well as in hemocytes of post-treated/recovered mussels (7 days post-treatment/recovery period)...
October 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29045432/inflammatory-response-and-oxidative-stress-during-liver-resection
#15
Christoph Schwarz, Fabian Fitschek, David Bar-Or, Daniel A Klaus, Bianca Tudor, Edith Fleischmann, Georg Roth, Dietmar Tamandl, Thomas Wekerle, Michael Gnant, Martin Bodingbauer, Klaus Kaczirek
BACKGROUND: Postoperative complications are still a major concern after liver resection (LR). Systemic inflammation and deregulated reactive oxygen species during major abdominal surgery may impair outcome after hepatectomy. METHODS: Patients undergoing LR were included in this study (n = 40). Oxidative stress (OS) was measured peri- and post-operatively as static oxidation-reduction potential markers (sORP) and antioxidant capacity ORP (cORP) by using the RedoxSYS Diagnostic system...
2017: PloS One
https://www.readbyqxmd.com/read/29045386/mfsd2b-is-essential-for-the-sphingosine-1-phosphate-export-in-erythrocytes-and-platelets
#16
Thiet M Vu, Ayako-Nakamura Ishizu, Juat Chin Foo, Xiu Ru Toh, Fangyu Zhang, Ding Ming Whee, Federico Torta, Amaury Cazenave-Gassiot, Takayoshi Matsumura, Sangho Kim, Sue-Anne E S Toh, Toshio Suda, David L Silver, Markus R Wenk, Long N Nguyen
Sphingosine-1-phosphate (S1P), a potent signalling lipid secreted by red blood cells and platelets, plays numerous biologically significant roles. However, the identity of its long-sought exporter is enigmatic. Here we show that the major facilitator superfamily transporter 2b (Mfsd2b), an orphan transporter, is essential for S1P export from red blood cells and platelets. Comprehensive lipidomic analysis indicates a dramatic and specific accumulation of S1P species in Mfsd2b knockout red blood cells and platelets compared with that of wild-type controls...
October 18, 2017: Nature
https://www.readbyqxmd.com/read/29044827/identifying-the-mechanism-of-escherichia-coli-o157-h7-survival-by-the-addition-of-salt-in-the-treatment-with-organic-acids
#17
Young-Min Bae, Jae-Hyun Yoon, Ji-Yeon Kim, Sun-Young Lee
AIM: In this study, the effects of addition of salt to treatment with acids (one of several organic acids and salt in various solutions including rich or minimal broth, buffer, or distilled water) on the reduction of Escherichia coli O157:H7 were investigated. The protein expression profiles corresponding to acid stress (acetic acid) with or without salt addition were studied using a comparative proteomic analysis of E. coli O157:H7. METHODS AND RESULTS: When acetic, lactic, or propionic acid was combined with 3% NaCl, mutually antagonistic effects of acid and salt on viability of E...
October 17, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/29044123/ire1%C3%AE-xbp1s-branch-of-upr-links-hif1%C3%AE-activation-to-mediate-angii-dependent-endothelial-dysfunction-under-particulate-matter-pm-2-5-exposure
#18
Xiuduan Xu, Aodeng Qimuge, Hongli Wang, Chen Xing, Ye Gu, Shasha Liu, Huan Xu, Meiru Hu, Lun Song
Short- and long-term exposure to particulate matter (PM) 2.5 instigates adverse health effect upon the cardiovascular (CV) system. Disclosing the molecular events by which PM2.5 evokes CV injuries is essential in developing effective risk-reduction strategy. Here we found that rats after intratracheally instillation with PM2.5 displayed increased circulating level of ANGII, the major bioactive peptide in renin-angiotensin-system (RAS), which resulted from the elevation of ANGII production in the vascular endothelium...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29043535/towards-multilevel-mental-stress-assessment-using-svm-with-ecoc-an-eeg-approach
#19
Fares Al-Shargie, Tong Boon Tang, Nasreen Badruddin, Masashi Kiguchi
Mental stress has been identified as one of the major contributing factors that leads to various diseases such as heart attack, depression, and stroke. To avoid this, stress quantification is important for clinical intervention and disease prevention. This study aims to investigate the feasibility of exploiting electroencephalography (EEG) signals to discriminate between different stress levels. We propose a new assessment protocol whereby the stress level is represented by the complexity of mental arithmetic (MA) task for example, at three levels of difficulty, and the stressors are time pressure and negative feedback...
October 18, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/29043342/antihypertensive-effects-of-tartary-buckwheat-flavonoids-by-improvement-of-vascular-insulin-sensitivity-in-spontaneously-hypertensive-rats
#20
Zuoxu Hou, Yuanyuan Hu, Xingbin Yang, Wensheng Chen
Vascular insulin resistance and oxidative stress contribute to endothelial dysfunction and hypertension. The present study investigated whether chronic treatment with purified Tartary buckwheat flavonoids fraction (TBF) prevents the development of hypertension via improving vascular insulin sensitivity and reducing oxidative stress. Six-week-old male spontaneously hypertensive rats (SHRs) and their normotensive Wistar-Kyoto (WKY) control rats were subjected to different dosages of TBF for 8 weeks. Blood pressure, mesenteric arteriolar vasorelaxation, superoxide anion (O2(-)) generation, NAD(P)H oxidase activity, and insulin-stimulated Akt/endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) production were determined...
October 18, 2017: Food & Function
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