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Beijing genotype and mycobacterium tuberculosis

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https://www.readbyqxmd.com/read/29151338/genotype-distribution-of-mycobacterium-tuberculosis-in-theaegean-region-and-associated-demographic-factors
#1
Cengiz Çavuşoğlu, Fethiye Ferda Yılmaz, İsabel Raika Durusoy Onmuş, Tuğba Bozdemir, Hüseyin Taşlı, Mine Hoşgör Limoncu
Background/aim: The Aegean Region is the second-ranking region in Turkey according to the Human Development Index and population density and it hosts 1/8 of Turkey's population. İzmir is the largest city of the region, receiving internal migration both from inside and outside the region. The tuberculosis incidence in İzmir is lower than overall in Turkey: 17.7/100,000 in 2011. Our aims were to determine genotypes of Mycobacterium tuberculosis isolates; to explore possible associations between genotypes with case-demographic data, clinical presentation, and antimicrobial susceptibility patterns; and to determine variations in genotype distribution of strains isolated in Ege University Hospital, İzmir...
November 13, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29142045/a-rapid-assay-for-detection-of-the-epidemiologically-important-central-asian-russian-strain-of-the-mycobacterium-tuberculosis-beijing-genotype
#2
Igor Mokrousov, Ekaterina Chernyaeva, Anna Vyazovaya, Yuriy Skiba, Natalia Solovieva, Violeta Valcheva, Klavdia Levina, Natalya Malakhova, Wei-Wei Jiao, Lia Lima Gomes, Philip N Suffys, Marge Kütt, Nagima Aitkhozhina, A-Dong Shen, Olga Narvskaya, Viacheslav Zhuravlev
Mycobacterium tuberculosis isolates of the Beijing 94-32-cluster (also named "Central Asian/Russian Beijing strain") constitute an important component of the population structure of the pathogen in the Former Soviet Union (FSU) countries (1-4).….
November 15, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29118425/the-study-on-the-association-between-beijing-genotype-family-and-drug-susceptibility-phenotypes-of-mycobacterium-tuberculosis-in-beijing
#3
Yi Liu, Xiaoying Jiang, Wensheng Li, Xuxia Zhang, Wei Wang, Chuanyou Li
The predominant prevalent Mycobacterium tuberculosis (M. tb) lineage was the Beijing genotype family in Beijing. There has been no systematic study on the association between drug resistance and Beijing genotype. Here we collected 268 M. tb strains, analyzed the background information and the bacteriological characteristics. The mean age of the cases was 40.12 years; male patients were almost three times than female patients. After genotyping analyzation, 81.7% (219/268) strains were categorized as Beijing genotype; no significant difference was observed between Beijing and non-Beijing genotype in gender, age and treatment history...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29092043/emerging-resistant-clones-of-mycobacterium-tuberculosis-in-a-spatiotemporal-context
#4
Anna Vyazovaya, Klavdia Levina, Viacheslav Zhuravlev, Piret Viiklepp, Marge Kütt, Igor Mokrousov
Objectives: We assessed the genetic structure of the Mycobacterium tuberculosis population in Estonia with a special focus on major epidemic/endemic clones and drug resistance determinants. We investigated the hypothesis of the decisive impact of massive human influx on the locally circulating genotypes. Estonia received a mass immigration from Russia during 1945-90 followed by enhanced interaction with the EU since 1991. Methods: The study sample included M. tuberculosis isolates from patients newly diagnosed with TB in 2014 in North Estonia (including the capital Tallinn)...
October 30, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29058526/mycobacterium-tuberculosis-of-the-beijing-genotype-in-iran-and-the-who-eastern-mediterranean-region-a-meta-analysis
#5
Sven Hoffner, Leyla Sahebi, Khalil Ansarin, Siamak Sabour, Parviz Mohajeri
OBJECTIVE: The Beijing genotype is a distinct genetic lineage of Mycobacterium tuberculosis, which is distributed worldwide, and may cause large outbreaks of multidrug resistance-tuberculosis (MDR-TB). The distribution of such strains in the Eastern Mediterranean region (EMR) is unclear, and clarifying the data is our purpose apart from the presence of Beijing TB in Iran. METHODS: We searched Published literature from CINAHL Cochrane Library, Current Contents, Database of Abstracts of Reviews of Effects (DARE), ProQuest Google Scholar PubMed, PsycINFO, Thomson Reuters, (SID), and Medical Library (MedLib) to detect relevant studies from the year 2000 to July 2015 with the following keywords: M...
October 23, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29050769/prevalence-of-beijing-and-haarlem-genotypes-among-multidrug-resistant-mycobacterium-tuberculosis-in-iran-systematic-review-and-meta-analysis
#6
REVIEW
Samira Tarashi, Abolfazl Fateh, Fatemeh Rahimi Jamnani, Seyed Davar Siadat, Farzam Vaziri
Antimicrobial drug resistance creates major problems in the control of tuberculosis (TB). Beijing and Haarlem genotypes of Mycobacterium tuberculosis are the prevalent genotypes responsible for multidrug resistant (MDR) TB worldwide. The aim of this study was to conduct a systematic review using meta-analysis to indicate the prevalence of Beijing and Haarlem genotypes among MDR-TB cases in Iran. Data sources of current study were 311 original articles (2006-2016) that were searched in several databases including Medline, Scopus, Embase, Cochrane library, and Iranian databases...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29046413/prediction-of-local-transmission-of-mycobacterium-tuberculosis-isolates-of-a-predominantly-beijing-lineage-using-a-variable-number-tandem-repeat-vntr-typing-method-incorporating-a-consensus-set-of-hypervariable-loci
#7
Yoshiro Murase, Kiyohiko Izumi, Akihiro Ohkado, Akio Aono, Kinuyo Chikamatsu, Hiroyuki Yamada, Yuriko Igarashi, Akiko Takaki, Satoshi Mitarai
Strain genotyping based on the variable-number tandem repeat (VNTR) is widely applied for identifying the transmission of Mycobacterium tuberculosis A consensus set of four hypervariable loci (1982, 3232, 3820, and 4120) has been proposed to improve the discrimination of Beijing lineage strains. Herein, we evaluated the utility of these four hypervariable loci for tracing local tuberculosis transmission in 981 cases over a 14-month period in Japan (2010--2011). We used six different VNTR systems, with or without the four hypervariable loci...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29032986/mycobacterium-tuberculosis-strains-induce-strain-specific-cytokine-and-chemokine-response-in-pulmonary-epithelial-cells
#8
Nontobeko E Mvubu, Balakrishna Pillay, Lyle R McKinnon, Manormoney Pillay
M. tuberculosis F15/LAM4/KZN has been associated with high transmission rates of drug resistant tuberculosis in the KwaZulu-Natal province of South Africa. The current study elucidated the cytokine/chemokine responses induced by representatives of the F15/LAM4/KZN and other dominant strain families in pulmonary epithelial cells. Multiplex cytokine analyses were performed at 24, 48 and 72h post infection of the A549 pulmonary epithelial cell line with the F15/LAM4/KZN, F28, F11, Beijing, Unique and H37Rv strains at an MOI of ∼10:1...
October 9, 2017: Cytokine
https://www.readbyqxmd.com/read/29031637/molecular-epidemiology-of-multi-and-extensively-drug-resistant-mycobacterium-tuberculosis-in-ireland-2001-2014
#9
E Roycroft, R F O'Toole, M M Fitzgibbon, L Montgomery, M O'Meara, P Downes, S Jackson, J O'Donnell, I F Laurenson, A M McLaughlin, J Keane, T R Rogers
OBJECTIVES: The primary objective of this work was to examine the acquisition and spread of multi-drug resistant (MDR) tuberculosis (TB) in Ireland. METHODS: All available Mycobacterium tuberculosis complex (MTBC) isolates (n = 42), from MDR-TB cases diagnosed in Ireland between 2001 and 2014, were analysed using phenotypic drug-susceptibility testing, Mycobacterial-Interspersed-Repetitive-Units Variable-Number Tandem-Repeat (MIRU-VNTR) genotyping, and whole-genome sequencing (WGS)...
October 12, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29018250/molecular-analysis-of-pyrazinamide-resistance-in-mycobacterium-tuberculosis-in-vietnam-highlights-the-high-rate-of-pyrazinamide-resistance-associated-mutations-in-clinical-isolates
#10
Nguyen Quang Huy, Contamin Lucie, Tran Thi Thanh Hoa, Nguyen Van Hung, Nguyen Thi Ngoc Lan, Nguyen Thai Son, Nguyen Viet Nhung, Dang Duc Anh, Bañuls Anne-Laure, Nguyen Thi Van Anh
Pyrazinamide (PZA) is a key antibiotic in current anti-tuberculosis regimens. Although the WHO has stressed the urgent need to obtain data on PZA resistance, in high tuberculosis burden countries, little is known about the level of PZA resistance, the genetic basis of such resistance or its link with Mycobacterium tuberculosis families. In this context, this study assessed PZA resistance through the molecular analysis of 260 Vietnamese M. tuberculosis isolates. First-line drug susceptibility testing, pncA gene sequencing, spoligotyping and mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) typing were performed...
October 11, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28947708/fitness-compensatory-mutations-facilitate-the-spread-of-drug-resistant-f15-lam4-kzn-and-f28-mycobacterium-tuberculosis-strains-in-kwazulu-natal-south-africa
#11
Charissa C Naidoo, Manormoney Pillay
While the acquisition of drug resistance is often accompanied by fitness costs, Mycobacterium tuberculosis has developed mechanisms to overcome these costs in the form of compensatory mutations. In an attempt to dissect strain-specific differences in biological fitness, 10 M. tuberculosis genomes, representing F15/LAM4/KZN, Beijing, F11 and F28 genotypes were sequenced on the Illumina MiSeq platform. Drug-susceptible F15/LAM4/KZN strains differed by 43 SNPs, demonstrating that heterogeneity exists even among closely-related strains...
September 2017: Journal of Genetics
https://www.readbyqxmd.com/read/28943727/a-genomic-signature-for-genotyping-mycobacterium-tuberculosis
#12
David Tarazona, Luis Jaramillo, Victor Borda, Kelly Levano, Marco Galarza, Heinner Guio
Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis (TB), has a vast diversity of genotypes including Beijing, CAS, EAI, Haarlem, LAM, X, Ural, T, AFRI1 and AFRI2. However, genotyping can be expensive, time consuming and in some cases, results may vary depending on methodology used. Here, we proposed a new set of 10 SNPs using a total of 249 MTB genomes, and selected by first the inclusion/ exclusion (IE) criteria using spoligotyping and phylogenies, followed by the selection of the nonsynonymous SNPs present in the most conserved cluster of orthologous groups (COG) of each genotype of MTB...
2017: Bioinformation
https://www.readbyqxmd.com/read/28919549/the-predominance-of-ethiopian-specific-mycobacterium-tuberculosis-families-and-minimal-contribution-of-mycobacterium-bovis-in-tuberculous-lymphadenitis-patients-in-southwest-ethiopia
#13
Mulualem Tadesse, Gemeda Abebe, Alemayehu Bekele, Mesele Bezabih, Pim de Rijk, Conor J Meehan, Bouke C de Jong, Leen Rigouts
BACKGROUND: Ethiopia has an extremely high rate of extrapulmonary tuberculosis, dominated by tuberculous lymphadenitis (TBLN). However, little is known about Mycobacterium tuberculosis complex (MTBc) lineages responsible for TBLN in Southwest Ethiopia. METHODS: A total of 304 MTBc isolates from TBLN patients in Southwest Ethiopia were genotyped primarily by spoligotyping. Isolates of selected spoligotypes were further analyzed by 15-loci mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) (n=167) and qPCR-based single nucleotide polymorphism (n=38)...
September 15, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28910939/-genotyping-and-drug-susceptibility-of-mycobacterium-tuberculosis-isolated-in-changping-district-in-beijing-2011-2015
#14
Z G Zhang, J F Wu, L Wang, L Q Wang, L Han, S B Ma, T J Gao
Objective: To understand the genotype distribution of Mycobacterium tuberculosis and the drug susceptibility of M. tuberculosis with different genotypes in Changping district of Beijing and evaluate the application of genotyping of M. tuberculosis in local tuberculosis (TB) prevention and control. Methods: A total of 1 099 M. tuberculosis strains isolated in Changping from 2011 to 2015 were used. Spoligotyping and 12-locus VNTR recommended by Gao were used for the genotyping of these isolates. In addition, the susceptibility of the M...
September 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28869227/a-study-on-beijing-genotype-in-the-clinical-isolates-of-pulmonary-drug-resistant-tuberculosis
#15
Ankit Kumar, Ajay Kumar Verma, Surya Kant, Ved Prakash, Anand Srivastava, Kanchan Srivastava, Amita Jain, Kishore K Srivastava
BACKGROUND: Mycobacterium tuberculosis (MTB) Beijing strains are spread worldwide and are responsible for major outbreaks of tuberculosis (TB), sometimes spreading multidrug resistance (MDR). AIM: The aim of this study was to explore clinical features associated with the infection with Beijing strains among MDR patients of pulmonary TB in Lucknow and surrounding areas. MATERIALS AND METHODS: It was a hospital-based epidemiological study. Our study population was selected from all the newly diagnosed patients attending outpatient department and admitted patients of Department of Respiratory Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India...
September 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/28835627/evolutionary-pathway-analysis-and-unified-classification-of-east-asian-lineage-of-mycobacterium-tuberculosis
#16
Egor Shitikov, Sergey Kolchenko, Igor Mokrousov, Julia Bespyatykh, Dmitry Ischenko, Elena Ilina, Vadim Govorun
Due to its rapid spread and association with the numerous outbreaks, the global spread of East Asian lineage of Mycobacterium tuberculosis strains presents a global concern. Although there were many attempts to describe its population structure, no consensus has been reached yet. To define unbiased classification that will facilitate future studies of this lineage, we analyzed the performance and congruence of eight different genotyping schemes based on phylogenetic analysis of 1,398 strains from 32 countries using whole-genome sequencing (WGS) data...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28789982/mycobacterium-tuberculosis-genotypes-and-predominant-clones-among-the-multidrug-resistant-isolates-in-spain-1998-2005
#17
Sofía Samper, Patricia Gavín, María Isabel Millán-Lou, María José Iglesias, María Soledad Jiménez, David Couvin, Nalin Rastogi
Although the incidence of tuberculosis (TB) is gradually decreasing in Spain, there is an increase in the proportion of foreign-born cases. This changing scenario is slowly shifting the local TB epidemiology from endemic to imported cases with an increased risk for multidrug-resistant (MDR) and extensively drug resistant (XDR) strains of Mycobacterium tuberculosis complex. MDR/XDR strains from Spain (n=366 MTBC isolates, 1 strain per patient) isolated between 1998 and 2005 were retained for this retrospective analysis...
August 5, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28745309/a-quantitative-and-efficient-approach-to-select-miru-vntr-loci-based-on-accumulation-of-the-percentage-differences-of-strains-for-discriminating-divergent-mycobacterium-tuberculosis-sublineages
#18
Xin-Ling Pan, Chun-Lei Zhang, Chie Nakajima, Jin Fu, Chang-Xia Shao, Li-Na Zhao, Jia-Yi Cui, Na Jiao, Chang-Long Fan, Yasuhiko Suzuki, Toshio Hattori, Di Li, Hong Ling
Although several optimal mycobacterial interspersed repetitive units-variable number tandem repeat (MIRU-VNTR) loci have been suggested for genotyping homogenous Mycobacterium tuberculosis, including the Beijing genotype, a more efficient and convenient selection strategy for identifying optimal VNTR loci is needed. Here 281 M. tuberculosis isolates were analyzed. Beijing genotype and non-Beijing genotypes were identified, as well as Beijing sublineages, according to single nucleotide polymorphisms. A total of 22 MIRU-VNTR loci were used for genotyping...
July 26, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28734764/comparative-genomic-analysis-of-mycobacterium-tuberculosis-beijing-like-strains-revealed-specific-genetic-variations-associated-with-virulence-and-drug-resistance
#19
Juan Germán Rodríguez-Castillo, Camilo Pino, Luis Fernando Niño, Juan Carlos Rozo, Claudia Llerena-Polo, Carlos A Parra-López, Andreas Tauch, Martha Isabel Murcia-Aranguren
Isolates of the Mycobacterium tuberculosis lineage 2/East-Asian are considered one of the most successful strains due to their increased pathogenicity, hyper-virulence associated with drug resistance, and high transmission. Recent studies in Colombia have shown that the Beijing-like genotype is associated with multidrug-resistance and high prevalence in the southwest of the country, but the genetic basis of its success in dissemination is unknown. In contribution to this matter, we obtained the whole sequences of six genomes of clinical isolates assigned to the Beijing-like genotype...
July 20, 2017: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/28710410/combining-molecular-typing-and-spatial-pattern-analysis-to-identify-areas-of-high-tuberculosis-transmission-in-a-moderate-incidence-county-in-taiwan
#20
Yih-Yuan Chen, Jia-Ru Chang, Chih-Da Wu, Yen-Po Yeh, Shiu-Ju Yang, Chih-Hao Hsu, Ming-Ching Lin, Ching-Fang Tsai, Ming-Shian Lin, Ih-Jen Su, Horng-Yunn Dou
In total, 303 randomly selected clinical Mycobacterium tuberculosis (MTB) isolates from 303 patients (collected January to December 2012) in central Taiwan were examined. The major lineages found were Beijing (N = 114, 37.62%), Haarlem (N = 76, 25.08%) and East African-Indian (EAI) (N = 42, 13.86%). Notably, younger persons (≤30 years old) were 6.58 times more likely to be infected with a Beijing genotype compared to older persons (>70 years) (p < 0.05). Combining molecular typing methods and geographical information system (GIS) analysis, we uncovered a twofold higher incidence of Beijing strains in a hotspot area (33%) compared to non-hotspot areas (17%)...
July 14, 2017: Scientific Reports
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