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https://www.readbyqxmd.com/read/28648309/economic-burden-of-community-acquired-pneumonia-among-pediatric-patients-aged-3-months-to-19-years-in-the-philippines
#1
Bernadette A Tumanan-Mendoza, Victor L Mendoza, Melchor Victor G Frias, Dolores D Bonzon
OBJECTIVE: 1) To determine the hospitalization, follow-up and total costs, and the economic burden of community-acquired pneumonia among pediatric patients aged 3 months to <19 years of age; 2) To compare the estimated cost of hospitalization to the pneumonia case rate payments of the Philippine Health Insurance Corporation (PhilHealth). METHODS: Using the societal perspective, both healthcare and non-healthcare costs were estimated. This was done through two tertiary private hospitals in the Philippines...
May 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/28648114/pseudohypoparathyroidism-type-1b-a-rare-cause-of-tetany-case-report
#2
Catarina Garcia, Cátia R Correia, Lurdes Lopes
Pseudohypoparathyroidism (PHP) is a rare group of disorders characterised by end-organ resistance to the parathyroid hormone (PTH). A 16-year-old boy presented with a 2-year history of involuntary dystonic movements involving mainly the left hand, initially after writing and later during physical exercise. Serum calcium was 1.37 mmol/L (2.20-2.69), phosphate 2.1 mmol/L (0.8-1.45) and PTH 302 ng/L (12-88). CT scan of the head demonstrated multiple subcortical and diffuse basal ganglia calcifications. Genetic analysis confirmed a methylation defect in the GNAS cluster on chromosome 20q13...
June 26, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28644568/treatment-of-avoidant-restrictive-food-intake-disorder-in-a-cohort-of-young-patients-in-a-partial-hospitalization-program-for-eating-disorders
#3
Rollyn M Ornstein, Jamal H Essayli, Terri A Nicely, Emily Masciulli, Susan Lane-Loney
OBJECTIVE: Avoidant/restrictive food intake disorder (ARFID) is a recently named condition to classify patients who present with restricted nutritional intake without body image distortion or fear of weight gain. We sought to compare treatment outcomes of patients with ARFID in a family-centered partial hospital program (PHP) to those with other eating disorders (ED). METHODS: A retrospective chart review of 130 patients 7 to 17 years of age admitted to the program from 2008 to 2012 was performed...
June 23, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28641462/microbiological-control-and-antibacterial-action-of-a-propolis-containing-mouthwash-and-control-of-dental-plaque-in-humans
#4
Karina Basso Santiago, Gilce Maria Piana, Bruno José Conti, Eliza de Oliveira Cardoso, Bruna Fernanda Murbach Teles Andrade, Mirella Rossitto Zanutto, Vera Lúcia Mores Rall, Ary Fernandes, José Maurício Sforcin
Propolis is a bee product with several biological properties. This study aimed at investigating a propolis-containing mouthwash, its organoleptic properties, microbial contamination and its antibacterial action in vitro. This mouthwash was assessed in vivo to control dental plaque in humans. The presence of microorganisms was analyzed and the minimum inhibitory concentration against Streptococcus mutans was determined. A comparative study was done in vivo using propolis, chlorhexidine, and propolis plus chlorhexidine in lower concentrations for 14 days...
June 23, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28641268/newgoa-predicting-new-go-annotations-of-proteins-by-bi-random-walks-on-a-hybrid-graph
#5
Guoxian Yu, Guangyuan Fu, Jun Wang, Yingwen Zhao
A remaining key challenge of modern biology is annotating the functional roles of proteins. Various computational models have been proposed for this challenge. Most of them assume the annotations of annotated proteins are complete. But in fact, many of them are incomplete. We proposed a method called NewGOA to predict new Gene Ontology (GO) annotations for incompletely annotated proteins and for completely un-annotated ones. NewGOA employs a hybrid graph, composed of two types of nodes (proteins and GO terms), to encode interactions between proteins, hierarchical relationships between terms and available annotations of proteins...
June 15, 2017: IEEE/ACM Transactions on Computational Biology and Bioinformatics
https://www.readbyqxmd.com/read/28634727/safety-and-efficacy-of-chemosaturation-in-patients-with-primary-and-secondary-liver-tumors
#6
Martha M Kirstein, Steffen Marquardt, Nils Jedicke, Silke Marhenke, Wolfgang Koppert, Michael P Manns, Frank Wacker, Arndt Vogel
BACKGROUND: Chemosaturation with percutaneous hepatic perfusion (CS-PHP; hepatic CHEMOSAT(®) delivery system; Delcath Systems Inc, USA) is a novel medical device, which delivers high doses of melphalan directly to the liver in patients with primary and secondary liver tumors while limiting systemic toxicity through hemofiltration of the hepatic venous blood. The aim of this study was to analyze the safety and efficacy of the second-generation CS-PHP after 54 treatments at Hannover Medical School, Germany...
June 20, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28634192/a-new-enzyme-linked-immunosorbent-assay-system-for-human-serum-hepatic-triglyceride-lipase
#7
Kazuya Miyashita, Katsuyuki Nakajima, Isamu Fukamachi, Yuji Muraba, Takafumi Koga, Yohnosuke Shimomura, Tetsuyo Machida, Masami Murakami, Junji Kobayashi
There is no previously established method for measuring human hepatic triglyceride lipase (HTGL) concentration in serum. In this study, we developed new monoclonal antibodies (MoAb mouse 9A1, MoAb rat 141A1) that react with both HTGL in serum and in post-heparin plasma (PHP) and established a novel enzyme-linked immunosorbent assay (ELISA) system for measuring serum HTGL as well as PHP-HTGL concentrations. To confirm the specificity of MoAb, we performed an immunoprecipitation -immunoblotting analysis. Both MoAb mouse 9A1and MoAb rat 141 A1 were able to immunoprecipitate not only recombinant HTGL and PHP-HTGL but also serum HTGL, demonstrating that HTGL exists in serum obtained without heparin injection...
June 20, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28628897/diverted-medications-and-new-psychoactive-substances-a-chemical-network-analysis-of-discarded-injecting-paraphernalia-in-hungary
#8
Valéria Anna Gyarmathy, Anna Péterfi, Tamás Figeczki, József Kiss, Katalin Medgyesi-Frank, János Posta, József Csorba
BACKGROUND: Until about 2010, people who inject drugs (PWIDs) injected almost exclusively heroin and amphetamines in Hungary. After 2010, self-reported studies have indicated a dominance of new psychoactive substances on the drug market for injectable drugs. METHODS: Between March 2015 and February 2016, we collected used and discarded injecting paraphernalia. We utilized chemical analysis to assess and UCINet to visualize the connections between the most prevalent main substances and their respective co-occurring additional components at 7 locations in Hungary...
June 16, 2017: International Journal on Drug Policy
https://www.readbyqxmd.com/read/28610638/baderi-an-online-database-to-coordinate-handsearching-activities-of-controlled-clinical-trials-for-their-potential-inclusion-in-systematic-reviews
#9
Hector Pardo-Hernandez, Gerard Urrútia, Leticia A Barajas-Nava, Diana Buitrago-Garcia, Julieth Vanessa Garzón, María José Martínez-Zapata, Xavier Bonfill
BACKGROUND: Systematic reviews provide the best evidence on the effect of health care interventions. They rely on comprehensive access to the available scientific literature. Electronic search strategies alone may not suffice, requiring the implementation of a handsearching approach. We have developed a database to provide an Internet-based platform from which handsearching activities can be coordinated, including a procedure to streamline the submission of these references into CENTRAL, the Cochrane Collaboration Central Register of Controlled Trials...
June 13, 2017: Trials
https://www.readbyqxmd.com/read/28610617/stimulating-collaboration-between-human-and-veterinary-health-care-professionals
#10
Björn G M Eussen, Jaap Schaveling, Maria J Dragt, Robert Jan Blomme
BACKGROUND: Despite the need to control outbreaks of (emerging) zoonotic diseases and the need for added value in comparative/translational medicine, jointly addressed in the One Health approach [One health Initiative (n.d.a). About the One Health Initiative. http://www.onehealthinitiative.com/about.php . Accessed 13 September 2016], collaboration between human and veterinary health care professionals is limited. This study focuses on the social dilemma experienced by health care professionals and ways in which an interdisciplinary approach could be developed...
June 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28596779/characterization-of-aldehyde-oxidase-ao-genes-involved-in-the-accumulation-of-carotenoid-pigments-in-wheat-grain
#11
Pasqualina Colasuonno, Ilaria Marcotuli, Maria L Lozito, Rosanna Simeone, Antonio Blanco, Agata Gadaleta
Aldehyde Oxidase (AO) enzyme (EC 1.2.3.1) catalyzes the final steps of carotenoid catabolism and it is a key enzyme in the abscisic acid (ABA) biosynthesis. AO isoforms are located in the cytosolic compartment of tissues in many plants, where induce the oxidation of aldehydes into carboxylic acid, and in addition, catalyze the hydroxylation of some heterocycles. The goal of the present study was to characterize the AO genes involved in the accumulation of carotenoid pigments in wheat grain, an important quantitative trait controlled by multiple genes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28580574/primary-hyperparathyroidism-in-pregnancy-a-review-of-literature
#12
Hanna Komarowska, Barbara Bromińska, Bartosz Luftmann, Marek Ruchała
Hyperparathyroidism during pregnancy is diagnosed in 0.5-1.4% women and poses a serious challenge. Symptoms of primary hyperparathyroidism (PHP), namely fatigue, lethargy and proximal muscle weakness, are unspecific and could be mistaken as complaints naturally present during pregnancy. Thus, diagnosis is usually delayed. Moreover, the complications of PHP are very common. They occur in 67% of mothers and even in up to 80% of progeny. Appropriate management is a matter of debate. According to clinical symptoms, biochemical evaluation and trimester of pregnancy an operation or conservative management should be introduced...
2017: Ginekologia Polska
https://www.readbyqxmd.com/read/28557535/peripapillary-atrophy-in-high-myopia
#13
Weifeng Liu, Liping Gong, Yingjie Li, Xuan Zhu, Jay M Stewart, Changyun Wang
PURPOSE: To evaluate peripapillary atrophy (PPA) in high myopia (HM) as a function of extent of myopia, axial length (AL), and age. METHODS: Medical records from patients (n = 88) seen in the Ophthalmology Department of the Third Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China, and diagnosed with high myopia (HM)-defined as spherical equivalent (SE) of >6.00 diopters (D) of myopia in either eye-were included in this study. Eyes were classified according to SE and age...
May 30, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28556531/effects-of-uncontrolled-periodontitis-on-marginal-bone-alterations-around-implants-a-case-control-study
#14
Xin Wang, Lei Qin, Chi Lei, Yu Li, Dehua Li
BACKGROUND: The hypothesis of bacterial infection initiating marginal bone loss around dental implant in analogy with natural tooth is still in debate. PURPOSE: The aim of this retrospective study was to investigate the effects of uncontrolled periodontitis on marginal bone alterations around implants compared with the periodontal health group at a mean follow-up of at least 6 years. MATERIALS AND METHODS: Thirty consecutive uncontrolled periodontally compromised patients (PCP) and 30 periodontally healthy patients (PHP), with a total of 96 Straumann implants (PCP = 55, PHP = 41) were matched for age, gender, smoking, and implant characteristics...
May 29, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28549078/herod-a-human-ethnic-and-regional-specific-omics-database
#15
Xian Zeng, Lin Tao, Zhang Peng, Chu Qin, Shangying Chen, Weidong He, Ying Tan, Hong Xia Liu, Sheng Yong Yang, Zhe Chen, Yu Yang Jiang, Yu Zong Chen
Motivation: Genetic and gene expression variations within and between populations and across geographical regions have substantial effects on the biological phenotypes, diseases, and therapeutic response. The development of precision medicines can be facilitated by the OMICS studies of the patients of specific ethnicity and geographic region. However, there is an inadequate facility for broadly and conveniently accessing the ethnic and regional specific OMICS data. Results: Here, we introduced a new free database, HEROD, a human ethnic and regional specific OMICS database...
May 26, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28544816/analytical-characterization-of-three-cathinone-derivatives-4-mpd-4%C3%A2-f-php-and-bk-epdp-purchased-as-bulk-powder-from-online-vendors
#16
Orapan Apirakkan, Anca Frinculescu, Trevor Shine, Mark C Parkin, Agostino Cilibrizzi, Nunzianda Frascione, Vincenzo Abbate
Novel emerging drugs of abuse, also referred as new psychoactive substances (NPS), constitute an ever-changing mixture of chemical compounds designed to circumvent legislative controls by means of chemical modifications of previously banned recreational drugs. One of such class, synthetic cathinones, namely β-keto derivatives of amphetamines, has been largely abused over the past decade. A number of new synthetic cathinones are detected each year, either in bulk powders/crystals or in biological matrices. It is therefore important to continuously monitor the supply of new synthetic derivatives and promptly report them...
May 23, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28544602/drug-residues-in-syringes-and-other-injecting-paraphernalia-in-hungary
#17
Anna Péterfi, József Csorba, Tamás Figeczki, József Kiss, Katalin Medgyesi-Frank, János Posta, V Anna Gyarmathy
The appearance and spread of new psychoactive substances (NPS) is a phenomenon detected throughout Europe since 2008. Synthetic cathinones, a group of NPS, have been self-reported as the drug injected by the vast majority of people who inject drugs (PWID) in Hungary. This study aims at updating our knowledge on what exactly the compounds injected by PWID. This multi-site study analysed residues from used injecting drug paraphernalia collected from PWID via low threshold services and from public places in Budapest, Debrecen, Miskolc, Szeged, Békéscsaba and Pécs between March 2015 and February 2016...
May 23, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28539341/advances-afoot-in-microbiology
#18
Robin Patel, Brad S Karon
In 2016, the American Academy of Microbiology convened a colloquium to examine point-of-care (POC) microbiology testing and to evaluate its effects on clinical microbiology. Colloquium participants included representatives from clinical microbiology laboratories, industry, and the government, who together made recommendations regarding the implementation, oversight, and evaluation of POC microbiology testing. The colloquium report is timely and well written (V. Dolen et al., Changing Diagnostic Paradigms for Microbiology, 2017, https://www...
July 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28529077/plmd-an-updated-data-resource-of-protein-lysine-modifications
#19
Haodong Xu, Jiaqi Zhou, Shaofeng Lin, Wankun Deng, Ying Zhang, Yu Xue
Post-translational modifications (PTMs) occurring at protein lysine residues, or protein lysine modifications (PLMs), play critical roles in regulating biological processes. Due to the explosive expansion of the amount of PLM substrates and the discovery of novel PLM types, here we greatly updated our previous studies, and presented a much more integrative resource of protein lysine modification database (PLMD). In PLMD, we totally collected and integrated 284,780 modification events in 53,501 proteins across 176 eukaryotes and prokaryotes for up to 20 types of PLMs, including ubiquitination, acetylation, sumoylation, methylation, succinylation, malonylation, glutarylation, glycation, formylation, hydroxylation, butyrylation, propionylation, crotonylation, pupylation, neddylation, 2-hydroxyisobutyrylation, phosphoglycerylation, carboxylation, lipoylation and biotinylation...
May 20, 2017: Journal of Genetics and Genomics, Yi Chuan Xue Bao
https://www.readbyqxmd.com/read/28525843/formation-of-platinum-ii-as-a-six-member-ring-for-sustained-polymeric-delivery
#20
Sanjeewa N Senadheera, Ti Zhang, Chad E Groer, M Laird Forrest
A new pH-activated polymer chelate of cisplatin was synthesized using a scalable and green aqueous technique. Synthesis of the chelate was based on formation of a 6-member ring of platinum(II) with acetyl-homo-Lysine (Ac-homo-Lys), which was accomplished under completely aqueous conditions using a traceless photocleavable protection chemistry. Synthesis preceded by, first, amidation of a photocaged homo-Ac-Lys with hyaluronic acid (HA) in water using a p-hydroxyphenacyl (pHP) group as the photoremovable protecting group, followed by reaction of cisplatin (diaqua form) in water to form the reversible chelate...
May 6, 2017: European Journal of Medicinal Chemistry
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