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https://www.readbyqxmd.com/read/29775322/prediction-of-human-cytochrome-p450-inhibition-using-a-multi-task-deep-autoencoder-neural-network
#1
Xiang Li, Youjun Xu, Luhua Lai, Jianfeng Pei
Adverse side effects of drug-drug interactions induced by human cytochrome P450 (CYP450) inhibition is an important consideration in drug discovery. It is highly desirable to develop computational models that can predict the inhibitive effect of a compound against a specific CYP450 isoform. In this study, we developed a multi-task model for concurrent inhibition prediction of five major CYP450 isoforms, namely 1A2, 2C9, 2C19, 2D6, and 3A4. The model was built by training multi-task autoencoder deep neural network (DNN) on a large dataset containing more than 13000 compounds, extracted from PubChem BioAssay Database...
May 18, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29774900/multiplex-detection-of-quality-indicator-molecule-targets-in-urine-using-programmable-hairpin-probes-based-on-a-simple-double-t-type-microchip-electrophoresis-platform-and-isothermal-polymerase-catalyzed-target-recycling
#2
Lingying Zhou, Ning Gan, Yongxiang Wu, Futao Hu, Jianyuan Lin, Yuting Cao, Dazhen Wu
Recently, it has been crucial to be able to detect and quantify small molecular targets simultaneously in biological samples. Herein, a simple and conventional double-T type microchip electrophoresis (MCE) based platform for the multiplex detection of quality indicator molecule targets in urine, using ampicillin (AMPI), adenosine triphosphate (ATP) and estradiol (E2) as models, was developed. Several programmable hairpin probes (PHPs) were designed for detecting different targets and triggering isothermal polymerase-catalyzed target recycling (IPCTR) for signal amplification...
May 18, 2018: Analyst
https://www.readbyqxmd.com/read/29769210/tidier-php-a-reporting-guideline-for-population-health-and-policy-interventions
#3
Mhairi Campbell, Srinivasa Vittal Katikireddi, Tammy Hoffmann, Rebecca Armstrong, Elizabeth Waters, Peter Craig
No abstract text is available yet for this article.
May 16, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29766646/psychosocial-variables-and-presence-severity-and-prognosis-of-plantar-heel-pain-a-systematic-review-of-cross-sectional-and-prognostic-associations
#4
Chris Drake, Adrian Mallows, Chris Littlewood
OBJECTIVE: Plantar heel pain (PHP) is often disabling, and persistent symptoms are common. Psychosocial variables are known to affect pain and disability but the association of these factors with PHP has yet to be established. The purpose of the present systematic review was to determine if psychosocial variables are associated with the presence, severity and prognosis of PHP. METHODS: A systematic review of the literature and qualitative synthesis was carried out...
May 15, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29766442/rate-of-improvement-of-pain-and-function-in-mid-portion-achilles-tendinopathy-with-loading-protocols-a-systematic-review-and-longitudinal-meta-analysis
#5
REVIEW
Myles Murphy, Mervyn Travers, William Gibson, Paola Chivers, James Debenham, Sean Docking, Ebonie Rio
BACKGROUND: Mid-portion Achilles tendinopathy is prevalent within both the athletic and non-athletic populations and loading protocols for Achilles tendinopathy are effective over time, though the rate of symptom change throughout rehabilitation is unknown. OBJECTIVE: The objective of this study was to determine the rate of change in pain and function over time in patients while completing a loading protocol for mid-portion Achilles tendinopathy. METHODS: A systematic review and longitudinal meta-analysis was conducted as per the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
May 15, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29760098/cochlear-amplification-and-tuning-depend-on-the-cellular-arrangement-within-the-organ-of-corti
#6
Hamid Motallebzadeh, Joris A M Soons, Sunil Puria
The field of cochlear mechanics has been undergoing a revolution due to recent findings made possible by advancements in measurement techniques. While it has long been assumed that basilar-membrane (BM) motion is the most important determinant of sound transduction by the inner hair cells (IHCs), it turns out that other parts of the sensory epithelium closer to the IHCs, such as the reticular lamina (RL), move with significantly greater amplitude for weaker sounds. It has not been established how these findings are related to the complex cytoarchitecture of the organ of Corti between the BM and RL, which is composed of a lattice of asymmetric Y-shaped elements, each consisting of a basally slanted outer hair cell (OHC), an apically slanted phalangeal process (PhP), and a supporting Deiters' cell (DC)...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29759425/simultaneous-evaluation-of-thermal-and-non-thermal-effects-of-high-intensity-focused-ultrasound-on-a-tissue-mimicking-phantom
#7
Yong Tae Kim, Donghee Ma, Jai Kyoung Sim, Se-Hwa Kim
Physiologically relevant phantoms with high reliability are essential for extending the therapeutic applications of high-intensity therapeutic ultrasound. Here we describe a tissue-mimicking phantom capable of quantifying temperature changes and observing non-thermal phenomena by high-intensity therapeutic ultrasound. Using polydiacetylene liposomes, we fabricated agar-based polydiacetylene hydrogel phantoms (PHPs) that not only respond to temperature, but also have acoustic properties similar to those of human liver tissue...
May 11, 2018: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/29756265/web-based-thyroid-imaging-reporting-and-data-system-malignancy-risk-of-atypia-of-undetermined-significance-or-follicular-lesion-of-undetermined-significance-thyroid-nodules-calculated-by-a-combination-of-ultrasonography-features-and-biopsy-results
#8
Young Jun Choi, Jung Hwan Baek, Jung Hee Shin, Woo Hyun Shim, Seon-Ok Kim, Won-Hong Lee, Dong Eun Song, Tae Yong Kim, Ki-Wook Chung, Jeong Hyun Lee
BACKGROUND: The purpose of this study was to construct a web-based predictive model using ultrasound characteristics and subcategorized biopsy results for thyroid nodules of atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) to stratify the risk of malignancy. METHODS: Data included 672 thyroid nodules from 656 patients from a historical cohort. We analyzed ultrasound images of thyroid nodules and biopsy results according to nuclear atypia and architectural atypia...
May 13, 2018: Head & Neck
https://www.readbyqxmd.com/read/29743153/integrated-models-of-care-for-people-living-with-hepatitis-c-virus-and-a-substance-use-disorder-protocol-for-a-systematic-review
#9
Lianping Ti, Stephanie Parent, María Eugenia Socías
BACKGROUND: People living with a substance use disorder (SUD) are a key population within the hepatitis C virus (HCV) epidemic. While integrated and community-based models of care have shown positive outcomes among this population, the literature has been primarily focused on the HIV context. This paper outlines a systematic review protocol on the impact of various integrated models of care, which includes HCV and SUD services, on various treatment, and health-related outcomes among this population...
May 9, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29742572/development-of-human-face-literature-database-using-text-mining-approach-phase-i
#10
Paramjit Kaur, Kewal Krishan, Suresh K Sharma
The face is an important part of the human body by which an individual communicates in the society. Its importance can be highlighted by the fact that a person deprived of face cannot sustain in the living world. The amount of experiments being performed and the number of research papers being published under the domain of human face have surged in the past few decades. Several scientific disciplines, which are conducting research on human face include: Medical Science, Anthropology, Information Technology (Biometrics, Robotics, and Artificial Intelligence, etc...
May 8, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29738928/high-salinity-relay-as-a-post-harvest-processing-method-for-reducing-vibrio-vulnificus-levels-in-oysters-crassostrea-virginica
#11
Corinne Audemard, Howard I Kator, Kimberly S Reece
High salinity relay of Eastern oysters (Crassostrea virginica) was evaluated as a post-harvest processing (PHP) method for reducing Vibrio vulnificus. This approach relies on the exposure of oysters to natural high salinity waters and preserves a live product compared to previously approved PHPs. Although results of prior studies evaluating high salinity relay as a means to decrease V. vulnificus levels were promising, validation of this method as a PHP following approved guidelines is required. This study was designed to provide data for validation of this method following Food and Drug Administration (FDA) PHP validation guidelines...
May 2, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29735475/effectiveness-of-internet-based-interventions-on-glycemic-control-in-patients-with-type-2-diabetes-meta-analysis-of-randomized-controlled-trials
#12
Ying Shen, Fengbin Wang, Xing Zhang, Xiaorou Zhu, Qiudan Sun, Edwin Fisher, Xinying Sun
BACKGROUND: The popularity of internet as an area of research has grown manifold over the years. Given its rapid development and increasing coverage worldwide, internet-based interventions seem to offer a promising option to ameliorate huge burdens brought by type 2 diabetes mellitus. However, studies conducted by different researchers have provided contradictory results on the effect of internet-based interventions in glycemic control. OBJECTIVE: This meta-analysis aims to summarize currently available evidence and evaluate the overall impact of internet-based interventions on glycemic management of type 2 diabetic patients...
May 7, 2018: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/29728838/interaction-between-nonsynonymous-polymorphisms-in-pla2g7-gene-and-smoking-on-the-risk-of-coronary-heart-disease-in-a-chinese-population
#13
Yunpeng Chi, Conghong Shi, Xiaojiang Zhang, Yang Xi
To investigate the impact of PLA2G7 polymorphism, and additional their interactions with smoking and drinking on coronary heart disease (CHD) risk based on Chinese population. GMDR model was used to screen the best gene-smoking and gene-drinking interaction combinations. Logistic regression was performed to investigate association between 4 SNPs and CHD, and the interaction effect between rs1805017 and smoking. For CHD patient-control haplotype analyses, the SHEsis online haplotype analysis software ( http://analysis...
May 4, 2018: Journal of Thrombosis and Thrombolysis
https://www.readbyqxmd.com/read/29697385/intensity-of-the-antioxidant-protection-system-and-oxidative-stress-factors-in-patients-with-non-alcoholic-steatohepatitis-depending-on-the-form-of-chronic-kidney-disease
#14
O Khukhlina, A Antoniv, L Kanovska, M Matushchak, V Vivsyannuk
The article presents a theoretical generalization of the research results the intensity of the antioxidant protection system and oxidative stress factors in patients with non-alcoholic steatohepatitis depending on the form of chronic kidney disease. The objective of the article - determining the pathogenetic role of the processes of antioxidant protection system in the development and interconnection mechanisms of non-alcoholic steatohepatitis (NASH) and obesity depending on the form and stage of chronic kidney disease (CKD)...
March 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29693731/genetic-and-epigenetic-defects-at-the-gnas-locus-lead-to-distinct-patterns-of-skeletal-growth-but-similar-early-onset-obesity
#15
Patrick Hanna, Virginie Grybek, Guiomar Perez de Nanclares, Léa C Tran, Luisa de Sanctis, Francesca Elli, Javier Errea, Bruno Francou, Peter Kamenicky, Léa Linglart, Arrate Pereda, Anya Rothenbuhler, Daniele Tessaris, Susanne Thiele, Alessia Usardi, Ashley H Shoemaker, Marie-Laure Kottler, Harald Jüppner, Giovanna Mantovani, Agnès Linglart
Pseudohypoparathyroidism type 1A (PHP1A), pseudoPHP (PPHP), and PHP type 1B (PHP1B) are caused by maternal and paternal GNAS mutations, and abnormal methylation at maternal GNAS promoter(s), respectively. Adult PHP1A patients are reportedly obese and short, whereas most PPHP patients are born small. In addition to PTH resistance, PHP1A and PHP1B patients may display early-onset obesity. As early-onset and severe obesity and short stature are daily burdens for PHP1A patients, we aimed at improving knowledge on the contribution of the GNAS transcripts to fetal and postnatal growth and fat storage...
April 25, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29689116/intermittent-furosemide-administration-in-patients-with-or-at-risk-for-acute-kidney-injury-meta-analysis-of-randomized-trials
#16
Tiziana Bove, Alessandro Belletti, Alessandro Putzu, Simone Pappacena, Giuseppe Denaro, Giovanni Landoni, Sean M Bagshaw, Alberto Zangrillo
BACKGROUND: Furosemide is the most common loop diuretic used worldwide. The off-label administration of furosemide bolus(es) for the prevention or to reverse acute kidney injury (AKI) is widespread but not supported by available evidence. We conducted a meta-analysis of randomized trials (RCTs) to investigate whether bolus furosemide to prevent or treat AKI is detrimental on patients' survival. METHODS: Electronic databases were searched through October 2017 for RCTs comparing bolus furosemide administration versus any comparator in patients with or at risk for AKI...
2018: PloS One
https://www.readbyqxmd.com/read/29688371/sptedb-a-database-for-transposable-elements-in-salicaceous-plants
#17
Fei Yi, Zirui Jia, Yao Xiao, Wenjun Ma, Junhui Wang
http://genedenovoweb.ticp.net:81/SPTEdb/index.php.
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29688359/dbdepc-3-0-the-database-of-differentially-expressed-proteins-in-human-cancer-with-multi-level-annotation-and-drug-indication
#18
Qingmin Yang, Yuqi Zhang, Hui Cui, Lanming Chen, Yong Zhao, Yong Lin, Menghuan Zhang, Lu Xie
https://www.scbit.org/dbdepc3/index.php.
January 1, 2018: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/29687605/shape-memory-properties-and-enzymatic-degradability-of-poly-%C3%AE%C2%B5-caprolactone-based-polyurethane-urea-containing-phenylalanine-derived-chain-extender
#19
Rong Wang, Fanjun Zhang, Weiwei Lin, Wenkai Liu, Jiehua Li, Feng Luo, Yaning Wang, Hong Tan
Biodegradable shape memory polymers are promising biomaterials for minimally invasive surgical procedures. Herein, a series of linear biodegradable shape memory poly(ε-caprolactone) (PCL)-based polyurethane ureas (PUUs) containing a novel phenylalanine-derived chain extender is synthesized. The phenylalanine-derived chain extender, phenylalanine-hexamethylenediamine-phenylalanine (PHP), contains two chymotrypsin cleaving sites to enhance the enzymatic degradation of PUUs. The degradation rate, the crystallinity, and mechanical properties of PUUs are tailored by the content of PHP...
April 24, 2018: Macromolecular Bioscience
https://www.readbyqxmd.com/read/29679302/association-of-abnormal-serum-potassium-levels-with-arrhythmias-and-cardiovascular-mortality-a-systematic-review-and-meta-analysis-of-observational-studies
#20
REVIEW
Liesa K Hoppe, Dana C Muhlack, Wolfgang Koenig, Prudence R Carr, Hermann Brenner, Ben Schöttker
PURPOSE: To provide the first systematic review and meta-analysis of observational studies on the association of abnormal serum potassium and cardiovascular outcomes. METHODS: Medline and ISI Web of Knowledge were systematically searched from inception until November 24, 2017. Data synthesis of relevant studies was performed using random effects model meta-analyses. RESULTS: Meta-analyses included 310,825 participants from 24 studies. In the older general population, low serum potassium was associated with a 1...
April 20, 2018: Cardiovascular Drugs and Therapy
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