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https://www.readbyqxmd.com/read/28532134/assessing-the-efficacy-of-second-line-antiretroviral-treatment-for-hiv-patients-failing-first-line-antiretroviral-therapy-in-iran-a-cohort-study
#1
Mehrnaz Rasooli-Nejad, Maryam Khazaee-Pool, Ladan Abbasian, Zahra Bayat Jozani, Sara Ahsani-Nasab, Banafsheh Moradmand Badie, Afsaneh Pargar, Gholamreza Esmaeeli Djavid
There are limited documents about HIV patients switched to second-line antiretroviral therapy (ART) in resource-limited countries. We aimed to assess the efficacy of second-line ART for HIV patients following first-line ART failure. This was a cohort study of HIV/AIDS patients with first-line ART treatment failure switched to second-line ART between January 2004 and March 2014, who followed for at least 12 months after switching. Fifty of studied patients (85%) were treated with regimens containing lopinavir/ritonavir (Kaletra) and nine of them (15%) treated with other regimes...
April 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28531643/lipid-based-nutrient-supplements-containing-vitamins-and-minerals-attenuate-renal-electrolyte-loss-in-hiv-aids-patients-starting-antiretroviral-therapy-a-randomized-controlled-trial-in-zambia
#2
D Munkombwe, T L Muungo, C Michelo, P Kelly, S Chirwa, S Filteau
BACKGROUND & AIMS: Advanced HIV infection combined with undernutrition and antiretroviral therapy (ART) places HIV/AIDS patients at high risk of electrolyte abnormalities and increased morbidity and mortality. Here, in a sub-study of a large published randomized trial, we evaluated if nutritional supplements will help curtail renal electrolyte loss in HIV/AIDS patients starting ART. METHODS: 130 malnourished HIV-positive patients referred for ART received lipid-based nutrient supplements alone (LNS, n = 63) or together with vitamins and minerals (LNS-VM, n = 67)...
June 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28531268/implementation-of-an-integrated-approach-to-the-national-hiv-aids-strategy-for-improving-human-immunodeficiency-virus-care-for-youths
#3
J Dennis Fortenberry, Linda J Koenig, Bill G Kapogiannis, Carrie L Jeffries, Jonathan M Ellen, Craig M Wilson
Importance: Youths aged 13 to 24 years old living with human immunodeficiency virus (HIV) are less likely than adults to receive the health and prevention benefits of HIV treatments, with only a small proportion having achieved sustained viral suppression. These age-related disparities in HIV continuum of care are owing in part to the unique developmental issues of adolescents and young adults as well as the complexity and fragmentation of HIV care and related services. This article summarizes a national, multiagency, and multilevel approach to HIV care for newly diagnosed youths designed to bridge some of these fragmentations by addressing National HIV/AIDS Strategy goals for people living with HIV...
May 22, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28531260/comparison-of-kaposi-sarcoma-risk-in-hiv-positive-adults-across-five-continents-a-multiregional-multicohort-study
#4
Julia Bohlius
Background: We compared Kaposi sarcoma (KS) risk in adults who initiated antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America. Methods: We included cohort data of HIV-positive adults who initiated ART after 1995 within the framework of two large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs). Results: We included 208,140 patients from 57 countries...
May 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28530684/tackling-hiv-and-aids-contributions-by-non-human-primate-models
#5
Koen K A Van Rompay
During the past three decades, non-human primate (NHP) models have gained an increasing importance in HIV basic and translational research. In contrast to natural host models, infection of macaques with virulent simian or simian-human immunodeficiency viruses (SIV, SHIV) results in a disease that closely resembles HIV infection and AIDS. Although there is no perfect animal model, and each of the available models has its benefits and limitations, carefully designed NHP studies with selection of experimental variables have unraveled important questions of basic pathogenesis and have provided the tools to explore and screen intervention strategies...
May 22, 2017: Lab Animal
https://www.readbyqxmd.com/read/28530444/real-world-strategies-to-engage-and-retain-racial-ethnic-minority-young-men-who-have-sex-with-men-in-hiv-prevention-services
#6
Thomas E Freese, Howard Padwa, Brandy T Oeser, Beth A Rutkowski, Marya T Schulte
Racial/ethnic minority young men who have sex with men (YMSM)-particularly African Americans and Hispanics/Latinos-are at particularly high risk for HIV infection. Devising strategies to improve engagement and retention in HIV prevention services among minority YMSM is critical if the United States is going to achieve the National HIV/AIDS Strategy goal of reducing HIV health-related disparities. This article presents findings from a national summit on racial/ethnic YMSM services convened by the Substance Abuse and Mental Health Services Administration-funded Center of Excellence on Racial and Ethnic Minority Young Men Who Have Sex with Men and Other Lesbian, Gay, Bisexual, and Transgender Populations (YMSM + LGBT CoE) in September 2015...
May 22, 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28530113/refining-current-scientific-priorities-identifying-new-scientific-gaps-in-hiv-related-heart-lung-blood-and-sleep-hlbs-research
#7
Homer L TwiggIII, Ronald Crystal, Judith Currier, Paul M Ridker, Nancy Berliner, Hans-Peter Kiem, George Rutherford, Shimian Zou, Simone Glynn, Renee Wong, Emmanuel Peprah, Michael Engelgau, Tony L Creazzo, Sandra Colombini-Hatch, Elisabet Caler
The National Heart, Lung and Blood Institute (NHLBI) AIDS Program's goal is to provide direction and support for research and training programs in areas of HIV-related heart, lung, blood and sleep (HLBS) diseases. To better define NHLBI current HIV-related scientific priorities and with the goal of identifying new scientific priorities and gaps in HIV-related HLBS research, a wide group of investigators gathered for a scientific NHLBI HIV Working Group on December 14-15, 2015, in Bethesda, MD. The core objectives of the Working Group included discussions on: 1) HIV-related HLBS comorbidities in the antiretroviral era; 2) HIV cure; 3) HIV prevention; and 4) mechanisms to implement new scientific discoveries in an efficient and timely manner so as to have the most impact on people living with HIV (PLWH)...
May 20, 2017: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/28530047/what-is-it-going-to-take-to-move-youth-related-hiv-programme-policies-into-practice-in-africa
#8
Daniella Mark, Lina Taing, Lucie Cluver, Chris Collins, Kate Iorpenda, Catarina Andrade, Luann Hatane
INTRODUCTION: HIV has been reported to be the leading cause of mortality amongst adolescents in Africa. This has brought attention to the changes in service provision and health management that many adolescents living with HIV experience when transferring from specialized paediatric- or adolescent-focused services to adult care. When transition is enacted poorly, adherence may be affected and the continuum of care disrupted. As the population of HIV-infected adolescents grows, effective and supported transition increases in significance as an operational imperative...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530037/where-do-hiv-infected-adolescents-go-after-transfer-tracking-transition-transfer-of-hiv-infected-adolescents-using-linkage-of-cohort-data-to-a-health-information-system-platform
#9
Mary-Ann Davies, Priscilla Tsondai, Nicki Tiffin, Brian Eley, Helena Rabie, Jonathan Euvrard, Catherine Orrell, Hans Prozesky, Robin Wood, Dolphina Cogill, Andreas D Haas, Annette H Sohn, Andrew Boulle
INTRODUCTION: To evaluate long-term outcomes in HIV-infected adolescents, it is important to identify ways of tracking outcomes after transfer to a different health facility. The Department of Health (DoH) in the Western Cape Province (WCP) of South Africa uses a single unique identifier for all patients across the health service platform. We examined adolescent outcomes after transfer by linking data from four International epidemiology Databases to Evaluate AIDS Southern Africa (IeDEA-SA) cohorts in the WCP with DoH data...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28530036/living-and-dying-to-be-counted-what-we-know-about-the-epidemiology-of-the-global-adolescent-hiv-epidemic
#10
Amy L Slogrove, Mary Mahy, Alice Armstrong, Mary-Ann Davies
INTRODUCTION: With increasing survival of vertically HIV-infected children and ongoing new horizontal HIV infections, the population of adolescents (age 10-19 years) living with HIV is increasing. This review aims to describe the epidemiology of the adolescent HIV epidemic and the ability of national monitoring systems to measure outcomes in HIV-infected adolescents through the adolescent transition to adulthood. METHODS: Differences in global trends between younger (age 10-14 years) and older (age 15-19 years) adolescents in key epidemic indicators are interrogated using 2016 UNAIDS estimates...
May 16, 2017: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/28529359/the-journey-of-opioid-substitution-therapy-in-india-achievements-and-challenges
#11
Ravindra Rao
Opioids are one of the most problematic illegal substances globally. Opioid abuse is associated with complications in various spheres of the user's life, his/her family, and the society. Injecting drug use (IDU) is also linked to public health problems such as HIV infection and viral hepatitis. Medications form an important cornerstone in the treatment of opioid dependence. Treatment strategies such as "detoxification" alone or long-term treatment with opioid antagonist have limited acceptability and retention rates...
January 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28529096/-the-changing-sex-differences-in-life-expectancy-in-spain-1980-2012-decomposition-by-age-and-cause
#12
Juan Manuel García González, Rafael Grande
OBJECTIVE: To calculate and analyse the contributions of changes in mortality by age groups and selected causes of death to sex differences in life expectancy at birth in Spain from 1980 to 2012. METHODS: Cross-sectional study with three time points (1980, 1995, and 2012). We used data from Human Cause-of-Death Database and Human Mortality Database. We use a decomposition method of the differences in life expectancy and gender differences in life expectancy from changes in mortality by 5-year age groups and causes of death between women and men...
May 19, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28528797/a-case-control-study-of-non-aids-defining-cancers-in-a-prospective-cohort-of-hiv-infected-patients
#13
Francisco Rodríguez Arrondo, Miguel Ángel von Wichmann, Xabier Camino, Miguel Ángel Goenaga, Maialen Ibarguren, Harkaitz Azcune, María Jesús Bustinduy, Oscar Ferrero, Josefa Muñoz, Sofía Ibarra, Koldo Aguirrebengoa, Josune Goicoetxea, Elena Bereciartua, Miguel Montejo, M Asunción García, Eduardo Martínez, Joseba Portu, Luis Metola, Rafael Silvariño, Cristina Sarasqueta, Julio Arrizabalaga, Jose Antonio Iribarren
INTRODUCTION: We present a case-control study of non-AIDS-defining cancers (NADCs) in a cohort of HIV-infected patients where we value the incidence, survival and prognostic factors of mortality. METHODS: All NADCs diagnosis conducted from 2007 to 2011 in 7 hospitals were collected prospectively, with a subsequent follow up until December 2013. A control group of 221 HIV patients without a diagnosis of cancer was randomly selected. RESULTS: Two hundred and twenty-one NADCs were diagnosed in an initial cohort of 7,067 HIV-infected patients...
May 18, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28528208/mentoring-interventions-and-the-impact-of-protective-assets-on-the-reproductive-health-of-adolescent-girls-and-young-women
#14
REVIEW
Kate F Plourde, Nicole B Ippoliti, Geeta Nanda, Donna R McCarraher
Adolescent girls and young women (AGYW) are disproportionately affected by HIV and AIDS and other negative reproductive health (RH) outcomes. Emerging evidence suggests that programs to build AGYW's assets can help reduce their vulnerability to poor RH. Mentoring interventions have demonstrated a positive impact on a variety of youth development outcomes, including the protective assets needed to circumvent poor RH outcomes. The purpose of this review was to understand the types of mentoring programs for AGYW that have demonstrated effectiveness in improving protective assets, and/or, RH knowledge, intentions, behaviors, or outcomes themselves...
May 17, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28527854/barriers-to-initiation-of-extended-release-naltrexone-among-hiv-infected-adults-with-alcohol-use-disorders
#15
Hélène Chokron Garneau, Alexandra Venegas, Richard Rawson, Lara A Ray, Suzette Glasner
Alcohol consumption is a major risk factor for the acquisition of HIV/AIDS and is associated with greater disease burden and mortality among those who become HIV-infected. Of the extant pharmacological treatments for alcohol use disorders, naltrexone is recognized as one of the most efficacious, producing robust reductions in alcohol craving and use. Given that treatment with oral naltrexone has been limited by problems with adherence, which are particularly prevalent among individuals with multiple chronic, co-occurring conditions, long-acting formulations may be a promising approach for HIV-infected substance users...
May 11, 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28527251/-pathological-findings-in-patients-with-hiv-infection-and-lymphadenopathies
#16
Federico Rodríguez-Vega, Miguel Botero, Jorge Alberto Cortés, Ángela Tobón
INTRODUCTION: Lymphadenopathy is a frequent clinical finding in HIV-infected patients. The differential diagnosis includes infection, malignancy or reactive changes. Currently, there are no data on this topic in the region. OBJECTIVES: To describe the etiology of lymph node pathology in HIV-infected patients from the Hospital La María in Medellín, Colombia. MATERIALS AND METHODS: The medical records of HIV-infected patients with lymphadenopathy who underwent excisional lymph node biopsy between June 2009 and October 2011 were retrospectively evaluated...
January 24, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28527158/asymptomatic-cryptococcal-antigenemia-in-people-living-with-hiv-plhiv-with-severe-immunosuppression-is-routine-crag-screening-indicated-in-india
#17
S Anuradha, Abhaya Narayana H, Richa Dewan, Ravinder Kaur, K Rajeshwari
BACKGROUND: Cryptococcal meningitis (CM) is a common, life-threatening opportunistic infection (OI) among people living with HIV (PLHIV) in India. Serum Cryptococcal antigen (CrAg) positivity is predictive of future occurrence of CM and pre-emptive treatment reduces its mortality. Routine CrAg screening among PLHIV is not adopted by India's national programme. This study evaluated the prevalence of CrAg and assessed CrAg positivity in predicting all-cause mortality among PLHIV. METHODS: This prospective study was conducted in a tertiary care, public health facility in New Delhi, India...
April 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28526661/the-parasol-protocol-an-implementation-science-study-of-hiv-continuum-of-care-interventions-for-gay-men-and-transgender-women-in-burma-myanmar
#18
Andrea L Wirtz, Soe Naing, Emily Clouse, Kaung Htet Thu, Sandra Hsu Hnin Mon, Zin Min Tun, Stefan Baral, Aung Zayar Paing, Chris Beyrer
BACKGROUND: Efforts to improve HIV diagnosis and antiretroviral therapy (ART) initiation among people living with HIV and reduce onward transmission of HIV rely on innovative interventions along multiple steps of the HIV care continuum. These innovative methods are particularly important for key populations, including men who have sex with men (MSM) and transgender women (TW). The HIV epidemic in Myanmar is concentrated among key populations, and national efforts now focus on reducing stigma and improving engagement of MSM and TW in HIV prevention and care...
May 17, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28525320/sexual-and-reproductive-health-priorities-of-adolescent-girls-in-lagos-nigeria-findings-from-free-listing-interviews
#19
Juliet Iwelunmor, Sarah Blackstone, Ucheoma Nwaozuru, Donaldson Conserve, Patricia Iwelunmor, John E Ehiri
Background Adolescent girls in Nigeria experience a disproportionately high burden of sexual and reproductive health disparities that affect their well-being. Yet, little is known about adolescent girls' own unique perspectives of the sexual and reproductive health challenges they face, and possible solutions to these challenges. Aims To explore top sexual and reproductive health concerns of female adolescents in Nigeria and their perceptions regarding potential solutions to these issues. Methods Eighty adolescent girls attending two public secondary schools in Lagos, Nigeria completed individual free-listing interviews...
May 17, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28523394/introduction-framing-post-aids-and-global-health-discourses-in-2015-and-beyond
#20
EDITORIAL
Gráinne O'Connell
This special issue, entitled "Post-AIDS' and Global Health Discourses: Interdisciplinary Perspectives,' emerged from a one day Medical Humanities symposium at the Leeds Centre for Medical Humanities, at the University of Leeds, England, on February 27th 2015. This special issue focusses on the perceived deprioritising of HIV and AIDS in the Sustainable Development Goals, or SDGs, that were launched in 2015. The SDGs function as policy benchmarks for all entities within the United Nations system and they supersede the Millennium Development Goals, or MDGs, which expired in 2015...
May 19, 2017: Journal of Medical Humanities
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