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Hunter syndrome adverse effect of Ert

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https://www.readbyqxmd.com/read/25887606/diagnosis-quality-of-life-and-treatment-of-patients-with-hunter-syndrome-in-the-french-healthcare-system-a-retrospective-observational-study
#1
Nathalie Guffon, Bénédicte Heron, Brigitte Chabrol, François Feillet, Vincent Montauban, Vassili Valayannopoulos
BACKGROUND: Mucopolysaccharidosis II (MPS II) is associated with a broad spectrum of chronic and progressive, life-limiting symptoms. Idursulfase is approved for MPS II enzyme replacement therapy (ERT) in over 50 countries. This retrospective study evaluated the MPS II burden, organization of clinical care, and effects of idursulfase treatment on the disease in France. METHODS: MPS II patients who had received idursulfase ERT in the French healthcare system were enrolled...
2015: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/23621439/ige-mediated-anaphylaxis-and-allergic-reactions-to-idursulfase-in-patients-with-hunter-syndrome
#2
J Kim, M R Park, D S Kim, J O Lee, S H Maeng, S Y Cho, Y Han, K Ahn, D K Jin
BACKGROUND: Enzyme replacement therapy (ERT) with recombinant human idursulfase is effective for the treatment of Hunter syndrome, mucopolysaccharidosis (MPS) type II. However, various adverse events can occur by the infusion of idursulfase. The purpose was to evaluate the occurrence of infusion-related allergic reactions, including anaphylaxis, to idursulfase in patients with MPS II receiving ERT and to elucidate its possible mechanism. METHODS: A total of 34 patients with MPS II were enrolled to receive ERT with Elaprase(®) at a dose of 0...
June 2013: Allergy
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