Maya A Dymova, Daria O Malysheva, Victoria K Popova, Elena V Dmitrienko, Anton V Endutkin, Danil V Drokov, Vladimir S Mukhanov, Arina A Byvakina, Galina V Kochneva, Polina V Artyushenko, Irina A Shchugoreva, Anastasia V Rogova, Felix N Tomilin, Anna S Kichkailo, Vladimir A Richter, Elena V Kuligina
Aptamers are currently being investigated for their potential to improve virotherapy. They offer several advantages, including the ability to prevent the aggregation of viral particles, enhance target specificity, and protect against the neutralizing effects of antibodies. The purpose of this study was to comprehensively investigate an aptamer capable of enhancing virotherapy. This involved characterizing the previously selected aptamer for vaccinia virus (VACV), evaluating the aggregation and molecular interaction of the optimized aptamers with the recombinant oncolytic virus VV-GMCSF-Lact, and estimating their immunoshielding properties in the presence of human blood serum...
February 14, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry