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Skin eruption

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https://www.readbyqxmd.com/read/27925156/case-report-of-multiple-pustules-of-the-bilateral-lower-limbs-caused-by-a-granulocyte-colony-stimulating-factor-producing-solid-pseudopapillary-tumour-of-the-pancreas
#1
Y Iwata, T Kobayashi, M Kuroda, Y Mizoguchi, M Arima, S Numata, S Watanabe, A Yagami, K Matsunaga, K Sugiura
Here we report the first case of neutrophilic dermatoses related to a granulocyte colony-stimulating factor (GCSF)-producing solid pseudopapillary tumour (SPT). The patient was a 39-year-old woman presenting with scattered pustules and crusts of the palms/heels/thighs and plaques of the bilateral lower legs. The skin biopsy revealed dense neutrophil infiltration in the epidermis to the corium. A pancreatic head tumour was detected on computed tomography. A pathological examination of the resected specimen suggested a SPT...
December 7, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27920678/diffuse-bullous-eruptions-in-an-elderly-woman-late-onset-bullous-systemic-lupus-erythematosus
#2
Prajwal Boddu, Mojtaba Nadiri, Owais Malik
Vesiculobullous eruptions in the elderly represent a diverse range of varying pathophysiologies and can present a significant clinical dilemma to the diagnostician. Diagnosis requires a careful review of clinical history, attention to detail on physical and histomorphological examination, and appropriate immunofluorescence testing. We describe the case of a 73-year-old female who presented to our hospital with a painful blistering skin rash developed over 2 days. Examination of the skin was remarkable for numerous flaccid hemorrhagic bullae on a normal-appearing nonerythematous skin involving both the upper and lower extremities...
September 2016: Case Reports in Dermatology
https://www.readbyqxmd.com/read/27906695/metformin-induced-generalized-fixed-drug-eruption-with-cutaneous-hemophagocytosis
#3
Jose Luis Rodríguez-Belver, Joaquin Lopez, Elena Macias, Laura Fuertes, Irene Andres, Victoria Alegria, Ignacio Gimeno, Alejandra Perez, Yosmar Perez, Luis Requena
Fixed drug eruption (FDE) consists of recurrent dusky-red to brownish macules or patches at the same sites after the readministration of the causative drug. It usually presents as a solitary lesion, but generalized eruptions have been described. The most frequently implied drugs are antibiotics, anticonvulsants, and analgesics. Only 2 cases due to metformin have been reported. Histopathologic features of FDE include vacuolar degeneration of the basal layer, necrotic keratinocytes, and superficial and deep perivascular lymphocytic infiltrate...
November 29, 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27900921/-a-fixed-drug-eruption-caused-by-paracetamol
#4
L van Zogchel, T Hendriks, S Adriaens, I Diederen, E Herremans
BACKGROUND: Fixed drug eruption is a hypersensitive skin response to drugs, which can present itself in different ways. The skin lesions are usually solitary, but can also appear as a maculopapular rash, Stevens-Johnson syndrome or toxic epidermal necrolysis. While fixed drug eruptions can be caused by various drugs, paracetamol is responsible in 1.5% of cases. CASE DESCRIPTION: A 58-year-old man was seen in general practice with a five-year-old exanthema on his torso, arms and legs...
2016: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/27886905/cutaneous-manifestation-of-drug-allergy-and-hypersensitivity
#5
REVIEW
Anna Zalewska-Janowska, Radoslaw Spiewak, Marek L Kowalski
Drug hypersensitivity reactions may manifest with either organ-specific or systemic symptoms, but cutaneous eruptions are the most common manifestations. Different medications may cause identical skin symptoms, whereas hypersensitivity to a single drug may manifest with various patterns of symptoms depending on the pathomechanism of hypersensitivity. Drug reactions should be also taken into account in the differential diagnosis of numerous skin rashes. Analysis of morphology of drug-induced lesions, about potential immunologic or nonimmunological mechanisms, is important for the final diagnosis...
February 2017: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/27884624/serum-il-21-levels-are-elevated-in-atopic-dermatitis-patients-with-acute-skin-lesions
#6
Hiromi Mizutani, Risa Tamagawa-Mineoka, Naomi Nakamura, Koji Masuda, Norito Katoh
BACKGROUND: Interleukin (IL)-21 is a member of the type I cytokine family and plays a role in the pathogenesis of T helper type 2 allergic diseases. It has been reported that IL-21 expression is upregulated in acute skin lesions in atopic dermatitis (AD) patients; however, little is known about the serum IL-21 levels of AD patients. The aim of this study was to quantify the serum IL-21 levels of AD patients and to evaluate the relationships between the serum IL-21 level and disease severity, laboratory markers, and eruption type in AD patients...
November 21, 2016: Allergology International: Official Journal of the Japanese Society of Allergology
https://www.readbyqxmd.com/read/27867744/iga-pemphigus-showing-iga-antibodies-to-desmoglein-1-and-3
#7
Salama Hegazy, Sana Bouchouicha, Aida Khaled, Lilia Laadher, Maryem Kallel Sellami, Faten Zeglaoui
BACKGROUND: IgA pemphigus is a rare autoimmune vesiculo-pustular skin disease. Only approximately 70 cases have been reported to date. We report a case of IgA pemphigus with IgA antibodies to desmoglein 1 (Dsg1) and desmoglein 3 (Dsg3). CASE REPORT: We report the case of an 60-year-old man with intraepidermal neutrophilic IgA pemphigus with IgA antibodies to Dsg1 and Dsg3. Histologic examination revealed subcorneal neutrophilic pustules with few acantholytic cells...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27862184/serum-sickness-like-drug-reaction-two-cases-with-a-neutrophilic-urticarial-pattern
#8
Cuong V Nguyen, Daniel D Miller
The diagnosis of serum sickness-like reaction (SSLR) is typically based on clinical findings. Histopathologic examination is often deferred, as these eruptions commonly present in young children, and often to primary care providers. A Pubmed literature search revealed only 5 existing cases of SSLR with described cutaneous histopathologic features. We report two cases of serum sickness-like reaction, one each to bupropion and cefazolin. Skin biopsy findings in both cases demonstrated a neutrophil-predominant urticarial pattern resembling neutrophilic urticaria or neutrophilic urticarial dermatosis...
November 10, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27845511/pustular-eruption-associated-with-granulocyte-colony-stimulating-factor-treatment
#9
Maria B Brumana, Irene Russo, Renato Zambello, Mauro Alaibac
We report a case of localized pustular eruption on the face in a patient with Hodgkin lymphoma treated with granulocyte colony-stimulating factor for the development of chemotherapy-induced neutropenia. The administration of granulocyte colony-stimulating factor and the level of neutrophils were closely associated with disease activity, and negative cultures ruled out the hypothesis of an infective etiology. Because of the role of colony-stimulating factor in mobilization of the neutrophils we considered this phenomenon a skin reaction caused by granulocyte colony- stimulating factor-driven neutrophil accumulation...
November 15, 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/27828699/levamisole-adulterated-cocaine-toxicity-would-you-recognize-it
#10
Suneela Cherlopalle, Manasa Enja, Melanie Lippmann, Steven Lippmann
Adulteration of cocaine with levamisole is common and can induce serious medical complications. Levamisole is an antihelminthic agent originally approved as an immunomodulator in the treatment of autoimmune disorders and as a chemotherapy adjunct. It was withdrawn from the US market in 2000 but is available in veterinary medicine. Cocaine-using patients may present with nonspecific constitutional symptoms, cutaneous eruptions, leukopenia, vasculitis, and organ damage. Skin manifestations may include severe necrosis, especially of the ear lobes...
July 14, 2016: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/27828643/fixed-drug-eruption-by-etoricoxib-confirmed-by-patch-test
#11
Aline Soares de Sousa, José Carlos Cardoso, Miguel Pinto Gouveia, Ana Rita Gameiro, Vera Barreto Teixeira, Maria Gonçalo
Non-steroidal, anti-inflammatory drugs, followed by antibiotics, are the main causes of fixed drug eruption. They provoke one or several round erythematous or bullous lesions that recur in the same place after taking the causative medication. A positive patch test on residual, lesional skin can replace satisfactorily oral reintroduction. We describe the case of a 74-year-old woman with numerous, rounded, erythematous lesions on the trunk and recurrent blistering on the fifth right-hand finger, which developed a few hours after taking etoricoxib...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27828639/acrokeratosis-verruciformis-of-hopf-case-report
#12
Tatiana Cristina Pedro Cordeiro de Andrade, Gardênia Viana da Silva, Tatiane Meira Pinho Silva, Ana Cecília Versiani Duarte Pinto, Adauto José Ferreira Nunes, Antônio Carlos Ceribelli Martelli
A 54 year-old woman with a 3-year history of rheumatoid arthritis (RA) consulted us because of weight loss, fever and skin eruption. On physical examination, erythematous plaques with a pseudo-vesicular appearance were seen on the back of both shoulders. Histological examination was consistent with rheumatoid neutrophilic dermatosis (RND). After three days of prednisone treatment, the skin eruption resolved. RND is a rare cutaneous manifestation of seropositive RA, characterized by asymptomatic, symmetrical erythematous plaques with a pseudo-vesicular appearance...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27824586/persistently-curly-hair-phenotype-with-the-use-of-nivolumab-for-squamous-cell-lung-cancer
#13
Constantin A Dasanu, Scott M Lippman, Steven C Plaxe
Increasing use of programmed cell death protein 1/programmed cell death protein 1 ligand inhibition for the treatment of patients with various malignancies such as advanced lung cancer, kidney cancer, and melanoma has resulted in valuable clinical responses, along with the occurrence of new and often puzzling side effects. Known cutaneous effects of CTLA4 and programmed cell death protein 1/programmed cell death protein 1 ligand inhibitors include generalized pruritus, vitiligo, maculopapular lesions, and lichenoid skin eruptions...
October 18, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27817206/subacute-radiation-dermatitis-following-an-interventional-cardiology-procedure
#14
Nélia Cunha, Pedro Cardoso, Joana Cabete
Although radiation dermatitis is a widely known complication of radiotherapy, its association with fluoroscopy-guided interventional procedures is yet underrecognized. We present a case of a 66-year-old man with a left scapular cutaneous lesion, initially diagnosed as a fixed drug eruption. The subsequent knowledge of a previous percutaneous aortic paravalvular leak closure procedure allowed a correct clinicopathological correlation and the final diagnosis of subacute radiodermatitis associated with fluoroscopy...
November 6, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27813483/-effects-of-volcanic-eruptions-on-human-health-in-iceland-review
#15
Gunnar Gudmundsson, Guðrun Larsen
Volcanic eruptions are common in Iceland and have caused health problems ever since the settlement of Iceland. Here we describe volcanic activity and the effects of volcanic gases and ash on human health in Iceland. Volcanic gases expelled during eruptions can be highly toxic for humans if their concentrations are high, irritating the mucus membranes of the eyes and upper respiratory tract at lower concentrations. They can also be very irritating to the skin. Volcanic ash is also irritating for the mucus membranes of the eyes and upper respiratory tract...
October 2016: Læknablađiđ
https://www.readbyqxmd.com/read/27812048/management-of-eczema-herpeticum-in-a-burn-unit
#16
Muhammad Sohail, Farid Ahmad Khan, Hussan Birkhez Shami, Muhammad Mustehsan Bashir
OBJECTIVE: To study the clinical features, course and outcome of eczema herpeticum in burn patients. METHODS: This prospective study was conducted at the King Edward Medical University / Mayo Hospital, Lahore, Pakistan, from November 2012 to October 2015, and comprised eczema herpeticum patients. Demographic and clinical features of the patients, treatment protocols and outcomes were noted. SPSS 18 was used for data analysis. RESULTS: Of the 18 patients, 10(56%) were females and 8(44%) were males...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27802779/assessment-of-demodex-presence-in-acne-like-rash-associated-with-cetuximab
#17
Deniz Aksu Arıca, Turkan Ozturk Topcu, Leyla Baykal Selçuk, Savas Yaylı, Unzile Seyman, Evren Fidan, Sevgi Bahadır, Halil Kavgacı
CONTEXT: Cetuximab is an epidermal growth factor receptor inhibitor. It is frequently used in the treatment of solid tumors. However, it has a high potential to cause acne-like rash. Demodex mites, which are known to increase in number in immunosuppressive circumstances, are closely related to the acneiform lesions. OBJECTIVE: The aim of this study is to evaluate the presence of demodex mites in acne-like rash that appears under the treatment of Cetuximab. METHODS: We reviewed the medical records of patients who applied to our clinic with cetuximab induced papulopustular rashes between November 2014 and March 2016...
November 16, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27784525/cutaneous-collagenous-vasculopathy-associated-benign-pigmented-purpura
#18
Warren R Heymann
A 68-year-old woman presented with an asymptomatic eruption predominantly on the proximal pretibial region of the right lower extremity, which had been present for many months. Her medical history was remarkable for diabetes and hypothyroidism. Physical examination demonstrated "cayenne pepper"-like brown macules, scattered petechiae, and multiple minute, blanching telangiectasias (Figure 1) that were more evident on dermatoscopy (Figure 2). The clinical differential diagnosis included a benign pigmented purpura (BBP; Schamberg type), telangiectasia macularis eruptiva perstans, cutaneous T-cell lymphoma, essential telangiectasia, and cutaneous collagenous vasculopathy (CCV)...
2016: Skinmed
https://www.readbyqxmd.com/read/27780370/ornidazole-induced-fixed-drug-reaction-on-sole-case-report-and-review-of-the-literature
#19
Selma Emre, Hilal Ahsen, Akın Aktaş
BACKGROUND: Fixed drug eruption is a special variant of drug reaction which is seen on skin or mucous membrane and typically recurs at the same location. Ornidazole-induced fixed drug eruption cases have been reported extremely rare. CASE: The 48-years old female patient was diagnosed as ornidazole-induced fixed drug reaction on the sole. The patient's history revealed that the lesion occurred for the third time in the last 6 months and she was administered ornidazole tablet by the gynecologist for 3 times due to genitourinary tract infection in the last 6 months...
October 26, 2016: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/27777430/a-case-of-streptobacillus-moniliformis-infection-with-cutaneous-leukocytoclastic-vasculitis
#20
Yoshio Kawakami, Takashi Katayama, Masayuki Kishida, Wakako Oda, Yasuro Inoue
A 71-year-old man presented with a high fever, polyarthralgia, petechiae and palpable purpura accompanied by livedoid change on his legs and feet. Histopathological findings of the purpura revealed perivascular infiltration of neutrophils, mononuclear cells, and nuclear debris, and extravasation of red cells mainly in the upper dermis: all signs consistent with leukocytoclastic vasculitis. Small vessel thrombi, which are characteristic features of septic vasculopathy, were also observed. Direct immunofluorescence showed negative results...
October 2016: Acta Medica Okayama
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