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https://www.readbyqxmd.com/read/28095713/disseminated-eruptive-granuloma-annulare-induced-by-levetiracetam
#1
Betul Sereflican, Tekden Karapinar, Selma Erdogan Duzcu, Şule Aydin Turkoglu
Granuloma annulare (GA) is a benign, granulomatous cutaneous disease without clear etiology. Disseminated and drug induced granuloma annulare is a rare presentation. We present a 47-year-old woman with diffuse circular erythematous eruptions following treatment with levetiracetam. Her clinical and histopathological findings were compatible with the diagnosis of granuloma annulare. To the best of our knowledge, there is no previous report of this skin disease as a result of levetiracetam use. We report this case to highlight this antiepileptic drug as a possible etiologic agent in disseminated granuloma annulare...
January 17, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28079921/four-cases-of-exogenous-acral-pigmentation-related-to-a-darkeling-beetle-coleoptera-tenebrionidae-blaps
#2
S Mokni, L Boussofara, W Saidi, A Aounallah, C Belajouza, N Ghariani, R Nouira, M Denguezli
Beetle (coleoptera) is the largest insect order colonizing all continents 1-2. Most of the beetles synthesize hemolymph containing several chemicals used as signals or defensive secretions against predators 2. Coleoptera body fluids can accidentally come into contact with humans' skin and induce dermatitis. Skin contact with the beetles commonly causes blistering skin eruption 3. This article is protected by copyright. All rights reserved.
January 12, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28074212/-specific-dermatoses-of-pregnancy
#3
REVIEW
C M Ambros-Rudolph, M Sticherling
The specific dermatoses of pregnancy represent a heterogeneous group of inflammatory skin diseases related to pregnancy and/or the postpartum period. A clinically relevant classification has been well established over the past 10 years and includes pemphigoid gestationis, polymorphic eruption of pregnancy, intrahepatic cholestasis of pregnancy, and atopic eruption of pregnancy. The hallmark of all four entities is severe pruritus that is accompanied by characteristic skin changes. While some of these dermatoses are distressing only to the mother because of pruritus, others may be associated with significant fetal risks...
January 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28063031/pharmacokinetics-and-pharmacodynamics-of-afamelanotide-and-its-clinical-use-in-treating-dermatologic-disorders
#4
REVIEW
Elisabeth I Minder, Jasmin Barman-Aksoezen, Xiaoye Schneider-Yin
Afamelanotide, the first α-melanocyte-stimulating hormone (MSH) analogue, synthesized in 1980, was broadly investigated in all aspects of pigmentation because its activity and stability were higher than the natural hormone. Afamelanotide binds to the melanocortin-1 receptor (MC1R), and MC1R signaling increases melanin synthesis, induces antioxidant activities, enhances DNA repair processes and modulates inflammation. The loss-of-function variants of the MC1R present in fair-skinned Caucasians are less effectively activated by the natural hormone...
January 6, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28052238/anti-psoriatic-potential-of-solanum-xanthocarpum-stem-in-imiquimod-induced-psoriatic-mice-model
#5
Komal M Parmar, Prakash R Itankar, Apurva Joshi, Satyendra K Prasad
ETHNOPHARMACOLOGICAL RELEVANCE: The plant Solanum xanthocarpum Schrad. & Wendl. (Solanaceae) is one of the members of the dashamula (ten roots) in Ayurvedic system of medicine. The stem and fruits are used as an antipyretic, antiasthmatic and is prescribed in skin infections and for relief in burning sensation in the feet accompanied by vesicular eruptions. OBJECTIVE: To scientifically validate the anti-psoriatic potential of Solanum xanthocarpum stem in Imiquimod-induced psoriatic mice model MATERIALS AND METHODS: Ethanolic stems extract of Solanum xanthocarpum (ESX) was first subjected to phytochemical screening and quantification of identified phytoconstituents, which was further standardized with the help of HPTLC using chlorogenic acid as a marker...
January 1, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28045205/anti-tumor-necrosis-factor-%C3%AE-induced-lupus-erythematosus-panniculitis
#6
Anne-Louise Durand, Jean-François Goussot, Denis Thiolat, Alain Taieb, Jérôme Marie, Julien Seneschal, Anne-Sophie Darrigade
Anti-tumor necrosis factor alpha (TNFα) therapies are used with success in many chronic inflammatory diseases. A wide range of adverse events has been reported in patients receiving these agents(1) , including lichenoid eruptions, lupus-like syndrome(1, 2) and psoriasiform eruptions(3) . Lupus erythematosus panniculitis (LEP) is a rare variant of cutaneous lupus erythematosus (CLE), which occurs approximately in 1%-3% of CLE. Here we report a case of a patient with rheumatoid arthritis (RA) treated with anti-TNFα that developed skin lesions clinically and pathologically compatible with LEP...
January 3, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28040372/human-polyomavirus-6-and-7-are-associated-with-pruritic-and-dyskeratotic-dermatoses
#7
Khang D Nguyen, Eunice E Lee, Yangbo Yue, Jiri Stork, Lumir Pock, Jeffrey P North, Travis Vandergriff, Clay Cockerell, Gregory A Hosler, Diana V Pastrana, Christopher B Buck, Richard C Wang
BACKGROUND: Human polyomavirus (HPyV)6 and HPyV7 are shed chronically from human skin. HPyV7, but not HPyV6, has been linked to a pruritic skin eruption of immunosuppression. OBJECTIVE: We determined whether biopsy specimens showing a characteristic pattern of dyskeratosis and parakeratosis might be associated with polyomavirus infection. METHODS: We screened biopsy specimens showing "peacock plumage" histology by polymerase chain reaction for HPyVs...
December 28, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28034667/adjunctive-hyperbaric-oxygen-therapy-in-severe-burns-experience-in-taiwan-formosa-water-park-dust-explosion-disaster
#8
I-Han Chiang, Shyi-Gen Chen, Kun-Lun Huang, Yu-Ching Chou, Niann-Tzyy Dai, Chung-Kan Peng
BACKGROUND: Despite major advances in therapeutic strategies for the management of patients with severe burns, significant morbidity and mortality is observed. Hyperbaric oxygen therapy (HBOT) increases the supply of oxygen to burn areas. The aim of this study was to determine whether HBOT is effective in the treatment of major thermal burns. METHODS: On June 27, 2015 in New Taipei, Taiwan, a mass casualty disaster occurred as fire erupted over a large crowd, injuring 499 people...
December 26, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28032173/clinical-outcomes-and-complications-associated-with-fractional-lasers-a-review-of-730-patients
#9
Steven R Cohen, Ashley Goodacre, Soobin Lim, Jennifer Johnston, Cory Henssler, Brian Jeffers, Ahmad Saad, Tracy Leong
BACKGROUND: Fractional lasers were introduced to provide increased safety, while maintaining high efficacy and patient satisfaction. Patients with virtually all Fitzpatrick skin types could be safely treated using a wide spectrum of wavelengths and a broad array of skin conditions, and aging could be addressed. Although safety studies have been reported for ablative CO2 and erbium lasers, surprisingly few data are available on adverse events and complications associated with fractional lasers...
December 28, 2016: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/28025783/idelalisib-induced-colitis-and-skin-eruption-mimicking-graft-versus-host-disease
#10
Muhammad Bader Hammami, Ahmad Al-Taee, Marshall Meeks, Mark Fesler, M Yadira Hurley, Dengfeng Cao, Jin-Ping Lai
INTRODUCTION: Idelalisib is a selective inhibitor of the delta isoform of phosphatidylinositol 3-kinase which was approved by the United States Federal Drug Administration in 2014 for the treatment of relapsed chronic lymphocytic leukemia and indolent non-Hodgkin lymphoma. Drug-induced injury of the gastrointestinal tract is a relatively frequent but usually under-recognized disease entity. CASE PRESENTATION: We report the case of a 56-year-old male with a history of relapsed follicular lymphoma status post allogenic bone marrow transplant who developed severe diarrhea with a skin eruption mimicking graft-versus-host disease (GVHD) 6 months after starting idelalisib...
December 26, 2016: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28004308/cutaneous-side-effects-and-transepidermal-water-loss-to-gefitinib-a-study-of-11-patients
#11
Franky Chandra, Dendi Sandiono, Unwati Sugiri, Oki Suwarsa, Hendra Gunawan
INTRODUCTION: Cutaneous side effects caused by epidermal growth factor receptor (EGFR) inhibitors occurred in 45-100% of patients which may lead to therapy modification or interruption. This study aimed to evaluate cutaneous side effects and transepidermal water loss (TEWL) values in non-small cell lung carcinoma (NSCLC) patients who received gefitinib EGFR inhibitor. METHODS: A descriptive observational study with cross-sectional design and a consecutive sampling method was conducted from 1 February to 4 March 2016...
December 21, 2016: Dermatology and Therapy
https://www.readbyqxmd.com/read/28002536/a-case-of-sweet-s-syndrome-associated-with-uveitis-in-a-young-male-with-ulcerative-colitis
#12
Ligia Ariana Bancu, Corina Ureche, Nicoleta Maria Crăciun, Dorin Marian
Sweet's syndrome is rare acute febrile neutrophilic dermatosis whose onset is either idiopathic or associated with other underlying conditions, such as infections, autoimmune diseases, pregnancy, use of certain medications, or malignancy. We report the case of a young male with known history of ulcerative colitis and abrupt onset of high fever, malaise, blurred vision and eruption of painful erythematous nodules and papules, localized on the head, neck, trunk and upper limbs. Ophthalmological examination established the diagnosis of anterior uveitis...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28000142/drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-with-teicoplanin-a-case-report
#13
Sholeh Ebrahimpour, Mehdi Mohammadi, Kheirollah Gholami
Intramuscular teicoplanin (400 mg every 12 h for three doses, then 400 mg daily, intramuscularly) was prescribed for a 37-year-old woman with presumptive diagnosis of cellulitis. On the 14th day of treatment, she developed generalized maculopapular rash, accompanied by fever, wheezing, shortening of breath, and lymphadenopathy. Lab tests revealed abnormal liver enzymes, leukocytosis, and eosinophilia. The treatment was interrupted with suspicion of drug reaction. Fever subsided after 48 h. Skin eruption and respiratory symptoms began to resolve within 2 weeks...
December 2017: Drug Safety—Case Reports
https://www.readbyqxmd.com/read/27999595/seborrheic-keratoses-as-the-first-sign-of-bladder-carcinoma-case-report-of-leser-tr%C3%A3-lat-sign-in-a-rare-association-with-urinary-tract-cancer
#14
Aline Stollmeier, Bernardo Augusto Rosario, Bruna Loise Mayer, Gibran Avelino Frandoloso, Francisco Luiz Gomide Mafra Magalhães, Gustavo Lenci Marques
Introduction. Skin disorders can be the first manifestation of occult diseases. The recognition of typical paraneoplastic dermatoses may anticipate the cancer diagnosis and improve its prognosis. Although rarely observed, the sudden appearance and/or rapid increase in number and size of seborrheic keratoses can be associated with malignant neoplasms, known as the sign of Leser-Trélat. The aim of this report is to unveil a case of a patient whose recently erupted seborrheic keratoses led to investigation and consequent diagnosis of bladder cancer...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27995212/is-this-a-simple-drug-eruption-to-be-discharged
#15
Mucahit Emet, Ilker Akbas, Esra Senturk, Omer Faruk Elmas, Sahin Aslan
'Erythema Multiforme associated with Phenytoin And Cranial radiation Therapy' (EMPACT) is a very rare clinic situation and classified in EM-like drug reactions. It can be easily misdiagnosed as acute urticaria or drug eruption in ED. Initial symptoms may resemble a simple skin problem, but diagnosing and early hospitalization of the patients can be lifesaving. Here, we present a man with renal cell cancer and brain metastases who admitted to ED due to fever and generalized rash. His skin lesions beginning from his head and spreading through the torso appeared four days after the end of radiotherapy (11 days after the initial dose of both radiation and oral phenytoin)...
December 2016: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27990673/trichodysplasia-spinulosa-in-a-7-year-old-boy-managed-using-physical-extraction-of-keratin-spicules
#16
Michael Barton, Suing Lockhart, Robert Sidbury, Richard Wang, Heather Brandling-Bennett
Trichodysplasia spinulosa (TS) is an uncommon skin disease characterized by a folliculocentric papular eruption and keratin spine formation, classically appearing on the central face and ears. It occurs in immunosuppressed patients and is linked to a viral etiology. Diagnostic tests including polymerase chain reaction (PCR) are available for detection of the TS-associated polyomavirus. Effective treatment options include topical cidofovir and oral valganciclovir. We present a case diagnosed using PCR with skin scrapings and treated using physical extraction of the keratin spicules...
December 19, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981612/cutaneous-reactions-in-children-treated-with-the-mitogen-activated-protein-kinase-extracellular-signal-regulated-kinase-inhibitor-trametinib-for-neural-tumors
#17
Christina Boull, Kristen Hook, Christopher Moertel, Sheilagh Maguiness
BACKGROUND: The mitogen-activated protein kinase (MAPK) pathway is a target for the treatment of a growing number of malignancies. The cutaneous reactions to medications that inhibit this pathway have not been described in children. METHODS: A retrospective chart review was completed for eight children with neural tumors treated with the MAPK extracellular signal-regulated kinase inhibitor trametinib. All children were evaluated by a pediatric dermatologist with documentation of cutaneous findings...
January 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/27978460/clinical-characteristics-of-headache-or-facial-pain-prior-to-the-development-of-acute-herpes-zoster-of-the-head
#18
Hye Lim Lee, Minju Yeo, Gi Hwa Choi, Ji Yeoun Lee, Ji Seon Kim, Dong-Ick Shin, Sang-Soo Lee, Sung-Hyun Lee
OBJECTIVES: When physicians encounter patients with headache or facial pain (preeruptive pain) associated with acute herpes zoster of the head, especially before the appearance of characteristic skin eruptions (preeruptive phase), they typically find it difficult to make clinical impressions and apply appropriate diagnostic or therapeutic procedures. The objectives of this study were to describe the clinical characteristics of headache or facial pain associated with acute herpes zoster of the head and to elucidate the association between the manifestation of these symptoms in the preeruptive phase and incoming herpes zoster...
January 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/27974963/bullous-systemic-lupus-erythematosus-and-lupus-nephritis-in-a-young-girl
#19
Tooba Momen, Yahya Madihi
Bullous systemic lupus erythematosus (BSLE) is an autoimmune blistering disease occurring in patients with systemic lupus erythematosus (SLE). It is a rare disease, especially in children. A 14-year-old girl initially presented with fatigue, generalized vesiculobullous skin lesions, and ulcers over the hard palate and oral mucosa. Clinical investigations revealed hematuria and proteinuria, a high erythrocyte sedimentation rate and titer of antinuclear antibody, and anti-double-stranded DNA. Skin biopsy findings were suggestive of BSLE...
November 2016: Oman Medical Journal
https://www.readbyqxmd.com/read/27938811/acral-manifestations-of-viral-infections
#20
Esra Adışen, Meltem Önder
Viruses are considered intracellular obligates with a nucleic acid RNA or DNA. They have the ability to encode proteins involved in viral replication and production of the protective coat within the host cells but require host cell ribosomes and mitochondria for translation. The members of the families Herpesviridae, Poxviridae, Papovaviridae, and Picornaviridae are the most commonly known agents for cutaneous viral diseases, but other virus families, such as Adenoviridae, Togaviridae, Parvoviridae, Paramyxoviridae, Flaviviridae, and Hepadnaviridae, can also infect the skin...
January 2017: Clinics in Dermatology
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