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Sandra N Bulens, Sarah H Yi, Maroya S Walters, Jesse T Jacob, Chris Bower, Jessica Reno, Lucy Wilson, Elisabeth Vaeth, Wendy Bamberg, Sarah J Janelle, Ruth Lynfield, Paula Snippes Vagnone, Kristin Shaw, Marion Kainer, Daniel Muleta, Jacqueline Mounsey, Ghinwa Dumyati, Cathleen Concannon, Zintars Beldavs, P Maureen Cassidy, Erin C Phipps, Nicole Kenslow, Emily B Hancock, Alexander J Kallen
In healthcare settings, Acinetobacter spp. bacteria commonly demonstrate antimicrobial resistance, making them a major treatment challenge. Nearly half of Acinetobacter organisms from clinical cultures in the United States are nonsusceptible to carbapenem antimicrobial drugs. During 2012-2015, we conducted laboratory- and population-based surveillance in selected metropolitan areas in Colorado, Georgia, Maryland, Minnesota, New Mexico, New York, Oregon, and Tennessee to determine the incidence of carbapenem-nonsusceptible A...
April 2018: Emerging Infectious Diseases
Osamu Kawase, Mitsuru Jimbo
Antisperm antibodies potentially inhibit sperm functions causing the sterility in humans and experimentally treated animals. However, there is no information about antisperm antibodies emerging spontaneously in wildlife. In this study, we searched for the sperm-reactive antibodies, spontaneously produced in wild sika deer (Cervus nippon), and identified the sperm antigens. We collected 529 fecal masses of sika deer in Japanese cities, from which we extracted the mucosal antibodies to test them for reactivities to deer sperm proteins by ELISA...
March 16, 2018: Journal of Veterinary Medical Science
M Gelardi, C Cavaliere, L Jannuzzi
Nasal cytology represents a useful, inexpensive and easy-to-apply diagnostic method to better detail the phenotypic characteristics of rhinitis. In fact, it allows to detect and quantify the cell population within the nasal mucosa at a given time. The technique involves sampling, processing and microscope reading. Sampling requires the collection of cells from the surface of nasal mucosa that is usually done by a sterile disposable curette. Samples should be collected from the middle portion of the inferior turbinate where the ratio ciliate/mucinous cells is expected to be well balanced...
January 2018: Journal of Biological Regulators and Homeostatic Agents
William Wong, Mohammed F Loya, Alexander Martynov, Salman S Shah, Dean Berman
Benign parotid lesions can grow to be a cosmetic deformation with psychological sequelae for a patient. Although surgical resection is the treatment of choice, cyst aspiration has also been attempted. This, however, has been shown to recur, requiring repeat intervention. An alternative therapeutic method not as widely recognized, but which has been reported to be both effective and less invasive than surgery for treating parotid cyst lesions, is sclerotherapy. Here we describe a report of a patient with a benign, localized, cystic neck mass refractory to 2 trials of fine needle aspiration...
February 2018: Radiology Case Reports
Ojan Assadian, Paul N Humphreys, Karen J Ousey
Disinfection of gloved hands is increasingly advocated in situations where visibly not soiled gloves are used during multiple clinical activities on the same patient. Since there is no data demonstrating that such practice attributes to lower bacterial transfer during clinical care, a standardised experimental study was conducted. Gloved hands touched chicken breasts contaminated with Staphylococcus epidermidis with or without disinfection before toughing sterile catheter valves. Contaminated gloves transferred 5...
March 15, 2018: Journal of Hospital Infection
Ye Jianwen, Hu Dingkai, Che Xuemei, Jiang Xiaoran, Li Teng, Chen Jinchun, Zhang Haoqian, Chen Guo-Qiang
Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) [P(3HB-co-4HB)] is one of the most promising biomaterials expected to be used in a wide range of scenarios. However, its large-scale production is still hindered by the high cost. Here we report the engineering of Halomonas bluephagenesis as a low-cost platform for non-sterile and continuous fermentative production of P(3HB-co-4HB) from glucose. Two interrelated 4-hydroxybutyrate (4HB) biosynthesis pathways were constructed to guarantee 4HB monomer supply for P(3HB-co-4HB) synthesis by working in concert with 3-hydroxybutyrate (3HB) pathway...
March 15, 2018: Metabolic Engineering
Anja Buttstedt, Carmen I Mureşan, Hauke Lilie, Gerd Hause, Christian H Ihling, Stefan-H Schulze, Markus Pietzsch, Robin F A Moritz
The female sex in honeybees (Apis spp.) comprises a reproductive queen and a sterile worker caste. Nurse bees feed all larvae progressively with a caste-specific food jelly until the prepupal stage. Only those larvae that are exclusively fed a large amount of royal jelly (RJ) develop into queens [1]. RJ is a composite secretion of two specialized head glands: the mandibular glands, which produce mainly fatty acids [2], and the hypopharyngeal glands, which contribute proteins, primarily belonging to the major royal jelly protein (MRJP) family [3]...
March 2, 2018: Current Biology: CB
Dong-Hyeon Lee, Jolanda Roux, Brenda D Wingfield, Michael J Wingfield
The African fungal tree pathogen, Ceratocystis albifundus, undergoes uni-directional mating type switching, giving rise to either self-fertile or self-sterile progeny. Self-sterile isolates lack the MAT1-2-1 gene and have reduced fitness such as slower growth and reduced pathogenicity, relative to self-fertile isolates. While it has been hypothesized that there is a 1:1 ratio of self-fertile to self-sterile ascospore progeny in relatives of C. albifundus, some studies have reported a significant bias in this ratio...
April 2018: Fungal Biology
Wei Ling Lean, Jennifer A Dawson, Peter G Davis, Christiane Theda, Marta Thio
INTRODUCTION: Umbilical venous catheter (UVC) placement is a common neonatal procedure. It is important to position the UVC tip accurately at the first attempt to prevent complications and minimise handling. Catheters positioned too low need to be removed, but catheters positioned too high may be withdrawn in a sterile fashion to a safe position. We aimed to determine the precision and accuracy of five published formulae developed to guide UVC placement. METHODS: This was a prospective observational study...
March 17, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
Pengfei Chu, Libo He, Lv Xiong, Lifei Luo, Rong Huang, Lanjie Liao, Yongming Li, Zuoyan Zhu, Yaping Wang
The mammalian sterile 20-like (MST) family, which belongs to the serine/threonine protein kinase superfamily, has five members that can be found in mammals: STK3 (also called MST2), STK4 (MST1), STK24 (MST3), STK25 (YSK1 or SOK1), and STK26 (MST4). The MST kinases have key roles in apoptosis, immune regulation, inflammatory responses, cancer, and cell proliferation in mammals, whereas the roles and transcriptional regulatory mechanism of these kinases in teleost fish are still unclear. In this study, four STK genes (CiSTK3, CiSTK24, CiSTK25, and CiSTK26) were cloned and analyzed in grass carp (Ctenopharyngodon idella)...
March 14, 2018: Fish & Shellfish Immunology
Charlotte Lybol, Sanne van der Coelen, Anouk Hamelink, Lidewij Ruth Bartelink, Theodoor Elbert Nieboer
STUDY OBJECTIVE: Endometrial ablation using the NovaSure system is one of the treatment options for heavy menstrual bleeding (HMB), which has a reported success rate of 81%-90%. We aimed to identify predictors for NovaSure endometrial ablation failure. This will contribute to a more effective and individualized pre-operative counseling. DESIGN: A retrospective multicenter cohort study (Canadian Task Force II-2) SETTING: One university hospital and one large teaching hospital...
March 14, 2018: Journal of Minimally Invasive Gynecology
Shayan Amiri, Aliakbar Yousefi-Ahmadipour, Mir-Jamal Hosseini, Arya Haj-Mirzaian, Majid Momeny, Heshmat Hosseini-Chegeni, Tahmineh Mokhtari, Sharmin Kharrazi, Gholamreza Hassanzadeh, Seyed Mohammad Amini, Somayeh Jafarinejad, Mahmoud Ghazi-Khansari
Silver nanoparticles (Ag-NPs) are currently used in a wide range of consumer products. Considering the small size of Ag-NPs, they are able to pass through variety of biological barriers and exert their effects. In this regard, the unique physicochemical properties of Ag-NPs along with its high application in the industry have raised concerns about their negative effects on human health. Therefore, it investigated whether prenatal exposure to low doses of Ag-NPs is able to induce any abnormality in the cognitive and behavioral performance of adult offspring...
March 14, 2018: Neurotoxicology
J Chen, J N Tang, K L Hu, Y Y Zhao, C Tang
In our previous research, 3-methyl-butanal and 3-methyl-butanoic acid were identified as representative and specific volatile organic compounds released by Staphylococcus aureus in broth. In this study, we explored the production of the 2 volatiles and their correlation to Staph. aureus growth in milk under different conditions. We found significant correlations between the production of 3-methyl-butanoic acid and cell counts of 5 Staph. aureus strains in sterile milk, and there were no obvious differences for its production among 5 tested strains...
March 14, 2018: Journal of Dairy Science
Jeffrey Zielich, Elena Tzima, Eva Ayla Schröder, Faten Jemel, Barbara Conradt, Eric J Lambie
P5B ATPases are present in the genomes of diverse unicellular and multicellular eukaryotes, indicating that they have an ancient origin, and that they are important for cellular fitness. Inactivation of ATP13A2, one of the four human P5B ATPases, leads to early-onset Parkinson's disease (Kufor-Rakeb Syndrome). The presence of an invariant PPALP motif within the putative substrate interaction pocket of transmembrane segment M4 suggests that all P5B ATPases might have similar transport specificity; however, the identity of the transport substrate(s) remains unknown...
2018: PloS One
Allison A Lindgren, Adam R Filipowicz, Julian B Hattler, Soon Ok Kim, Hye Kyung Chung, Marcelo J Kuroda, Edward M Johnson, Woong-Ki Kim
OBJECTIVE: HIV-1 infection of the brain and related cognitive impairment remain prevalent in HIV-1-infected subjects despite combination antiretroviral therapy. Sterile alpha motif and histidine-aspartate domain-containing protein 1 (SAMHD1) is a newly identified host restriction factor that blocks the replication of HIV-1 and other retroviruses in myeloid cells. Cell-cycle-regulated phosphorylation at residue Thr592 and viral protein X (Vpx)-mediated degradation of SAMHD1 have been shown to bypass SAMHD1 restriction in vitro...
March 15, 2018: AIDS
Charles-Antoine Guilloux, Claudie Lamoureux, Geneviève Héry-Arnaud
Lungs were considered as sterile for a long time. However, it is now evident that the lungs of healthy people are colonized by microorganisms. Among the bacteria present in the pulmonary microbiota, a significant proportion is anaerobic (strict or facultative). Even though interest in the pulmonary microbiota is increasing, few studies have focused on these unknowns that represent the lung resident anaerobic bacteria. This review describes the biodiversity of anaerobes in physiological conditions, and in different chronic respiratory diseases (cystic fibrosis, COPD, asthma)...
March 2018: Médecine Sciences: M/S
Xiao-Mei Fang, Jing-Lin Bai, Jing Su, Li-Li Zhao, Hong-Yu Liu, Bai-Ping Ma, Yu-Qin Zhang, Li-Yan Yu
Three actinomycete strains originating from the surface-sterilized roots of Paris polyphylla were characterized by using a polyphasic approach. Phylogenetic analyses based on the 16S rRNA gene sequence showed that they formed a deep, monophyletic branch in the genus Glycomyces, and were most closely related to the type strains of the species Glycomyces harbinensis and Glycomycesscopariae. Morphological and chemotaxonomic data supported the affiliation of strains CPCC 204357T , CPCC 204354 and CPCC 204355 to the genus Glycomyces...
March 16, 2018: International Journal of Systematic and Evolutionary Microbiology
Nailia R Khasbiullina, Nadezhda V Shilova, Maxim E Navakouski, Alexey Yu Nokel, Yuri A Knirel, Ola Blixt, Nicolai V Bovin
Innate immunity natural Abs (NAbs) execute a number of functions, including protection and surveillance. Despite active research, the stimuli that induce the formation of NAbs are still described only hypothetically. Here, we compared repertoires of anti-glycan Abs in the peripheral blood of mice that received per os various bacteria. The repertoires of Abs of mice primed in this way were compared using a microarray that included about 350 glycans, as well as 150 bacterial polysaccharides. Sterile mice did not possess anti-glycan Abs...
January 1, 2018: Innate Immunity
Ke Xie, Suowei Wu, Ziwen Li, Yan Zhou, Danfeng Zhang, Zhenying Dong, Xueli An, Taotao Zhu, Simiao Zhang, Shuangshuang Liu, Jinping Li, Xiangyuan Wan
Map-based cloning of maize ms33 gene showed that ZmMs33 encodes a sn-2 glycerol-3-phosphate acyltransferase, the ortholog of rice OsGPAT3, and it is essential for male fertility in maize. Genetic male sterility has been widely studied for its biological significance and commercial value in hybrid seed production. Although many male-sterile mutants have been identified in maize (Zea mays L.), it is likely that most genes that cause male sterility are unknown. Here, we report a recessive genetic male-sterile mutant, male sterility33 (ms33), which displays small, pale yellow anthers, and complete male sterility...
March 15, 2018: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
Sandrine Mariaux, Ulrika Furustrand Tafin, Olivier Borens
Introduction : When treating periprosthetic joint infection with a two-stage procedure, antibiotic-impregnated spacers can be used in the interval between prosthetic removal and reimplantation. In our experience, cultures of sonicated spacers are most often negative. The objective of the study was to assess whether that sonication causes an elution of antibiotics, leading to elevated antibiotic concentrations in the sonication fluid inhibiting bacterial growth and thus causing false-negative cultures. Methods : A prospective monocentric study was performed from September 2014 to March 2016...
2018: Journal of Bone and Joint Infection
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