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Yan Yan, Shangzhao Qiu, Zhuxuan Jin, Sihong Gong, Yun Bai, Jianwei Lu, Tianwei Yu
MOTIVATION: The biological regulatory system is highly dynamic. The correlations between many functionally related genes change over different biological conditions. Finding dynamic relations on the existing biological network may reveal important regulatory mechanisms. Currently no method is available to detect subnetwork-level dynamic correlations systematically on the genome-scale network. Two major issues hampered the development. The first is gene expression profiling data usually do not contain time course measurements to facilitate the analysis of dynamic relations, which can be partially addressed by using certain genes as indicators of biological conditions...
September 25, 2016: Bioinformatics
Daria Lizneva, Richard Kirubakaran, Kateryna Mykhalchenko, Larisa Suturina, Galina Chernukha, Michael P Diamond, Ricardo Azziz
OBJECTIVE: To compare the prevalence of polycystic ovary syndrome (PCOS) phenotypes and obesity among patients detected in referral versus unselected populations. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Thirteen thousand seven hundred ninety-six reproductive-age patients with PCOS, as defined by the extended Rotterdam 2003 criteria. INTERVENTION(S): Review of PUBMED, EMBASE, and Cochrane Library, 2003-2016...
August 13, 2016: Fertility and Sterility
Cindy W Mikeal, J Arthur Gillaspy, Michael T Scoles, John J Murphy
The current study used a dismantling design to investigate the relative efficacy of components of the Partners for Change Outcome Management System (PCOMS; Duncan, 2012). Clients (n = 94) from a university counseling center were randomly assigned to 1 of 3 conditions: PCOMS Full, Outcome Rating Scale (ORS)-only, or Session Rating Scale (SRS)-only and nested within therapists (n = 12). Results from hierarchical linear modeling and a 2-way analysis of variance indicated no statistically significant differences in outcome or rate of change on the Behavior Symptom Checklist-18 (BSI-18; Derogatis, 2001) across all 3 conditions...
August 11, 2016: Journal of Counseling Psychology
Ricardo Azziz, Enrico Carmina, ZiJiang Chen, Andrea Dunaif, Joop S E Laven, Richard S Legro, Daria Lizneva, Barbara Natterson-Horowtiz, Helena J Teede, Bulent O Yildiz
Polycystic ovary syndrome (PCOS) affects 5-20% of women of reproductive age worldwide. The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology (PCOM) - with excessive androgen production by the ovaries being a key feature of PCOS. Metabolic dysfunction characterized by insulin resistance and compensatory hyperinsulinaemia is evident in the vast majority of affected individuals. PCOS increases the risk for type 2 diabetes mellitus, gestational diabetes and other pregnancy-related complications, venous thromboembolism, cerebrovascular and cardiovascular events and endometrial cancer...
2016: Nature Reviews. Disease Primers
Aneta Gawlik, Michael Shmoish, Michaela F Hartmann, Ewa Malecka-Tendera, Stefan A Wudy, Ze'ev Hochberg
CONTEXT: The profile of urinary steroids as measured by GS-MS defines a subject's 'steroidal fingerprint'. OBJECTIVE: Here, we clustered steroidal fingerprints to characterize patients with non-syndromic childhood obesity by 'steroid metabolomic signatures'. HYPOTHESIS: Non-syndromic obesity is a symptom of different diseases and conditions, some of them will have their own signature. DESIGN: 31 steroid metabolites were quantified by GC-MS and their excretion rates were Z-transformed...
August 9, 2016: Journal of Clinical Endocrinology and Metabolism
Belinda J Anderson, Benjamin Kligler, Hillel W Cohen, Paul R Marantz
CONTEXT: Research literacy and the practice of evidence-based medicine (EBM) are important initiatives in complementary and alternative medicine (CAM), which requires cultural change within educational institutions for successful implementation. OBJECTIVE: To determine the self-assessed research and EBM perspectives of Chinese medicine Masters degree students at Pacific College of Oriental Medicine, New York campus (PCOM-NY). DESIGN AND METHODS: A survey with 17 close-ended questions and one open-ended question was administered through Survey Monkey to students at PCOM-NY...
September 2016: Explore: the Journal of Science and Healing
Robert L Rosenfield, David A Ehrmann
Polycystic ovary syndrome (PCOS) was hypothesized to result from functional ovarian hyperandrogenism (FOH) due to dysregulation of androgen secretion in 1989-1995. Subsequent studies have supported and amplified this hypothesis. When defined as otherwise unexplained hyperandrogenic oligoanovulation, two-thirds of PCOS cases have functionally typical FOH, characterized by 17-hydroxyprogesterone hyperresponsiveness to gonadotropin stimulation. Two-thirds of the remaining PCOS have FOH detectable by testosterone elevation after suppression of adrenal androgen production...
October 2016: Endocrine Reviews
Sayied Abdol Mohieb Hosainey, Torstein R Meling
Unruptured intracranial aneurysms occur in 1-3 % of the general population, and the risk of rupture is generally considered to be low. However, patients with multiple aneurysms and familial predisposition carry a particular risk of subarachnoid hemorrhage (SAH). A 54-year-old hypertensive man underwent screening with a head CT angiography (CTA) because of his comorbidities. CTA revealed multiple bilateral aneurysms around the circle of Willis. At first surgery, seven aneurysms were clipped (BA, ACOM, ICA ×2, and MCA ×3), two of which were detected intraoperatively only...
October 2016: Neurosurgical Review
Kabir Sardana, Chanchal Singh, Isha Narang, Shivani Bansal, Vijay K Garg
BACKGROUND: In persistent female acne, PCOS (polycystic ovarian syndrome) is a common finding. To diagnose PCOM (polycystic ovarian morphology), transvaginal - USG is required, which is not possible in virginal women. Also, hyperandrogenemia is not consistently reported. OBJECTIVES: The aim of the study was to compare the hormonal profile of persistent acne patients with or without PCOS and to assess the role of AMH (antimullerian hormone) in persistent acne patients...
June 20, 2016: Journal of Cosmetic Dermatology
Agathe Dumont, Didier Dewailly, Pauline Plouvier, Sophie Catteau-Jonard, Geoffroy Robin
CONTEXT: Ovulation induction in patients having both functional hypothalamic amenorrhea (FHA) and polycystic ovarian morphology (PCOM) has been less studied in the literature. As results remain contradictory, no recommendations have yet been established. OBJECTIVE: To compare pulsatile GnRH therapy versus gonadotropins for ovulation induction in "FHA-PCOM" patients and to determine if one treatment strikes as superior to the other. METHODS: A 12-year retrospective study, comparing 55 "FHA-PCOM" patients, treated either with GnRH therapy (38 patients, 93 cycles) or with gonadotropins (17 patients, 53 cycles)...
June 3, 2016: Gynecological Endocrinology
Ricardo Azziz
The polycystic ovary syndrome (PCOS) is recognized as one of the most common endocrine abnormalities of humans, with global prevalences so far generally 5%-15%. Overall, the disorder appears to be an ancient complex genetic trait, perhaps dating at least 50,000 years ago. The phenotype of PCOS can be subdivided into four different types. Phenotype A and B (hyperandrogenism + ovulatory dysfunction, with [A] and without [B] polycystic ovarian morphology [PCOM], respectively) can be considered to represent the "classic" form of the disorder...
July 2016: Fertility and Sterility
Fahimeh Ramezani Tehrani, Mahnaz Bahri Khomami, Atieh Amouzegar, Fereidoun Azizi
OBJECTIVE: To evaluate the association between polycystic ovarian morphology (PCOM) and thyroperoxidase antibody level. METHODS: A cross-sectional study was undertaken of women aged 15-49years living in one of four provinces in Iran recruited between February 2009 and November 2010. Eligible women did not have hirsutism and were eumenorrheic. All participants underwent a comprehensive interview, clinical examination, blood sampling, and ultrasonographic assessment...
August 2016: International Journal of Gynaecology and Obstetrics
Héctor F Escobar-Morreale, M Belén Roldán-Martín
BACKGROUND: A few small studies have reported increased prevalences of polycystic ovary syndrome (PCOS) and symptoms of androgen excess in women with type 1 diabetes. PURPOSE: We performed a systematic review and meta-analysis of studies evaluating androgen excess symptoms and PCOS in women with type 1 diabetes. DATA SOURCES: The Entrez-PubMed and Scopus electronic databases were used. STUDY SELECTION: We selected studies addressing androgen excess signs, symptoms, and disorders in girls, adolescents, and adult women with type 1 diabetes...
April 2016: Diabetes Care
Tamar R Binyamin, Brian C Dahlin, Ben Waldau
Posterior communicating artery (PCOM) aneurysms may cause third nerve palsies. The optimal treatment with clipping versus coiling remains controversial. Here we report on two cases of resolution of third nerve palsy after flow diversion embolization of large and giant PCOM aneurysms without adjuvant coil placement. The resolution of third nerve palsy was not preceded by significant shrinkage of the aneurysmal sac on MRI. However, one patient showed resolution of T2-weighted signal abnormalities in the midbrain and mesial temporal lobe despite a similar size of the aneurysm...
September 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Didier Dewailly
The diagnostic criteria for polycystic ovarian syndrome (PCOS) have been grouped in different classifications that have been conflicting for many years. At present, the classification of Rotterdam is the most used, but with varying frequency depending on the country and medical specialties. This classification is now >10 years old. Although its fundamental principle (two criteria required out of three) is still valid, each of its three items (oligo-anovulation (OA), hyperandrogenism (HA), and polycystic ovarian morphology (PCOM)) needs to be updated...
March 31, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
Agathe Dumont, Didier Dewailly, Pauline Plouvier, Sophie Catteau-Jonard, Geoffroy Robin
BACKGROUND: Pulsatile GnRH therapy is the gold standard treatment for ovulation induction in women having functional hypothalamic amenorrhea (FHA). The use of pulsatile GnRH therapy in FHA patients with polycystic ovarian morphology (PCOM), called "FHA-PCOM", has been little studied in the literature and results remain contradictory. The aim of this study was to compare the outcomes of pulsatile GnRH therapy for ovulation induction between FHA and "FHA-PCOM" patients in order to search for an eventual impact of PCOM...
2016: Reproductive Biology and Endocrinology: RB&E
Ruo-Yan Zhu, Yee-Chee Wong, Eu-Leong Yong
The morphological features of the ovaries in women with polycystic ovary syndrome (PCOS) have been well described by ultrasound imaging technology. These include enlarged ovary size, multiple small follicles of similar size, increased ovarian stromal volume and echogenicity, peripheral distribution of the follicles, and higher stromal blood flow. Ultrasound identification of the presence of polycystic ovarian morphology (PCOM) has been recognized as a component of PCOS diagnosis. With the advance of ultrasound technology, new definition has been proposed recently...
April 1, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
M Bahri Khomami, F Ramezani Tehrani, S Hashemi, N Mohammadi, H Rashidi, F Azizi
STUDY QUESTION: Is polycystic ovary morphology (PCOM) associated with metabolic syndrome (MS), insulin resistance (IR) and dyslipidemia? SUMMARY ANSWER: No associations between PCOM and metabolic disorders were found. WHAT IS KNOWN ALREADY: Polycystic ovary morphology has a prevalence of 21-63% in healthy women of reproductive age. Results of studies focusing on metabolic abnormalities among females with PCOM, are insufficient and controversial...
June 2016: Human Reproduction
Mario Zanaty, Nohra Chalouhi, Robert M Starke, Pascal Jabbour, Katherine O Ryken, Ketan R Bulsara, David Hasan
The pipeline embolization device has emerged as an important endovascular option. This is in part due to safety, efficacy, and possibly the ability to shorten the operative time considerably. With this new technology, some limitations are emerging as experience accumulates. We report three cases of posterior communicating (PCOM) artery aneurysms associated with fetal posterior cerebral artery where pipeline embolization was unsuccessful in obliterating the aneurysms. PCOM artery aneurysms associated with a fetal PCA should be managed either by microsurgical clipping or coiling when feasible...
2016: Case Reports in Vascular Medicine
Tetsuya Takakuwa, Teppei Koike, Taiga Muranaka, Chigako Uwabe, Shigehito Yamada
The circle of Willis (CW) is a circulatory anastomosis that supplies blood to the brain and adjacent structures. We examined the timing of formation of CW in 20 Japanese human embryo samples by using 3-dimensional reconstruction of serial histological sections. The CW was closed in 1 (n = 6), 2 (n = 8), 2 (n = 3) and 2 (n = 3) samples at Carnegie stages 20, 21, 22, and 23, respectively. The CW was unclosed in 13 samples (unclosed at ACOM alone, 6 samples; ACOM and bilateral P1, 4; left PCOM and right P1, 1; right PCOM and right P1, 1; ACOM and left PCOM, 1)...
September 2016: Congenital Anomalies
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