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https://www.readbyqxmd.com/read/28505246/effects-of-long-term-exogenous-testosterone-administration-on-ovarian-morphology-determined-by-transvaginal-3d-ultrasound-in-female-to-male-transsexuals
#1
Mirte R Caanen, Nienke E Schouten, Esther A M Kuijper, Joukje van Rijswijk, Marleen H van den Berg, Eline van Dulmen-den Broeder, Annelies Overbeek, Flora E van Leeuwen, Mick van Trotsenburg, Cornelis B Lambalk
STUDY QUESTION: Does long-term exogenous testosterone administration result in polycystic ovarian morphology (PCOM), determined by (3D) transvaginal ultrasound (TVU) in female-to-male transsexuals (FtMs). SUMMARY ANSWER: Long-term exogenous testosterone administration in FtMs does not result in PCOM determined by (3D) TVU. WHAT IS KNOWN ALREADY: The role of androgens in the pathophysiology of polycystic ovary syndrome (PCOS) is still unclear...
May 13, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28454499/phenotypic-variation-in-anti-mullerian-hormone-amh-production-per-follicle-in-women-with-polycystic-ovary-syndrome-pcos-and-isolated-polycystic-ovarian-morphology-pcom-an-observational-cross-sectional-study
#2
Priya Bhide, Abhijit Kulkarni, Merve Dilgil, Puja Dhir, Amit Shah, Anil Gudi, Roy Homburg
This observational study compares the ratio of serum anti-Mullerian hormone (AMH) to the total antral follicle count (AFC) (as a marker of AMH production per follicle) in the various phenotypes of women with polycystic ovary syndrome (PCOS) and isolated polycystic ovarian morphology (PCOM). Two hundred and sixty-two women were recruited. Women with PCOS were divided into four phenotypes based on the diagnostic inclusion criteria of oligo-anovulation (OA), hyperandrogenism (HA) and polycystic ovarian morphology (PCOM)...
April 28, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28381699/relationship-between-serum-anti-mullerian-hormone-and-clinical-parameters-in-polycystic-ovary-syndrome
#3
Toshiya Matsuzaki, Munkhsaikhan Munkhzaya, Takeshi Iwasa, Altankhuu Tungalagsuvd, Kiyohito Yano, Yiliyasi Mayila, Rie Yanagihara, Takako Tokui, Takeshi Kato, Akira Kuwahara, Sumika Matsui, Minoru Irahara
Polycystic ovary syndrome (PCOS) is an ovulatory disorder that affects 6-10% of women of reproductive age. Serum AMH level may be an additional factor, or surrogate of PCOM, in the diagnostic criteria of PCOS. We evaluated the correlations between the serum AMH level and various endocrine and metabolic features in PCOS using the latest fully automated assay. Serum AMH level was compared between 114 PCOS patient (PCOS group) and 95 normal menstrual cycle women (Control group). Correlations between serum AMH level and various endocrine and metabolic factors were analysed in PCOS group...
April 1, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28335839/apolipoprotein-l1-variants%C3%A2-and-blood-pressure-traits-in%C3%A2-african-americans
#4
Girish N Nadkarni, Geneviève Galarneau, Stephen B Ellis, Rajiv Nadukuru, Jinglan Zhang, Stuart A Scott, Claudia Schurmann, Rongling Li, Laura J Rasmussen-Torvik, Abel N Kho, M Geoffrey Hayes, Jennifer A Pacheco, Teri A Manolio, Rex L Chisholm, Dan M Roden, Joshua C Denny, Eimear E Kenny, Erwin P Bottinger
BACKGROUND: African Americans (AA) are disproportionately affected by hypertension-related health disparities. Apolipoprotein L1 (APOL1) risk variants are associated with kidney disease in hypertensive AAs. OBJECTIVES: This study assessed the APOL1 risk alleles' association with blood pressure traits in AAs. METHODS: The discovery cohort included 5,204 AA participants from Mount Sinai's BioMe biobank. Replication cohorts included additional BioMe (n = 1,623), Vanderbilt BioVU (n = 1,809), and Northwestern NUgene (n = 567) AA biobank participants...
March 28, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28303209/mixed-aneurysm-a-new-proposed-nomenclature-for-a-rare-condition
#5
Cassiano U Crusius, Paulo Henrique P de Aguiar, Marcelo U Crusius
BACKGROUND: Mixed intracranial aneurysms are vascular lesions appearing in the ruptured saccular aneurysms whose blood is contained by perivascular tissues forming another cavity called pseudoaneurysm. All cases until now have been reported in the literature with subarachnoid hemorrhage. CASE DESCRIPTION: A 65-year-old woman presented with multiple brain aneurysms with no history of subarachnoid hemorrhage. Endovascular treatment was chosen for left-sided aneurysms [lateral carotid wall (LCW) and posterior communicating (PCom)]...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28238423/a-computational-algorithm-for-classifying-step-and-spin-turns-using-pelvic-center-of-mass-trajectory-and-foot-position
#6
Pawel R Golyski, Brad D Hendershot
Transient changes in direction during ambulation are typically performed using a step (outside) or spin (inside) turning strategy, often identified through subjective and time-consuming visual rating. Here, we present a computational, marker-based classification method utilizing pelvic center of mass (pCOM) trajectory and time-distance parameters to quantitatively identify turning strategy. Relative to visual evaluation by three independent raters, sensitivity, specificity, and overall accuracy of the pCOM-based classification method were evaluated for 90-degree turns performed by 3 separate populations (5 uninjured controls, 5 persons with transtibial amputation, and 5 persons with transfemoral amputation); each completed turns using two distinct cueing paradigms (i...
January 30, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28198523/diversity-among-posterior-thalamoperforating-branches-originated-from-p1-segment-systematic-review
#7
Cezary Grochowski, Ryszard Maciejewski
BACKGROUND: The P1 segment of the posterior cerebral artery (PCA) begins at the termination of the basilar artery and ends at the origin of posterior communicating artery (PCoM), within the interpeduncular cistern. Perforating branches arising from this segment are called posterior thalamoperforating arteries and the main and biggest artery among those is called thalamoperforating artery (TPA). Perforating branches are a crucial component of cerebrovascular system supplying the posterior part of the thalamus, subthalamus, hypothalamus, substantia nigra, perforated substance, posterior part of internal capsule and the nucleus of III and IV cranial nerve...
February 15, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28090185/characteristics-and-outcomes-of-patients-with-anterior-circulation-intracranial-aneurysm-managed-with-clipping-in-hospital-sungai-buloh
#8
Ailani Ab Ghani, Saiful Azli Mat Nayan, Regunath Kandasamy, Azmin Kas Rosman, Abdul Rahman Izani Ghani
INTRODUCTION: The annual incidence of intracranial aneurysm in Malaysia is estimated to be 1.1-1.7 per 100,000 population based on a study done conducted in 1988. Since then, little epidemiological research has been conducted in Malaysia, and the real incidence is therefore probably unreported despite advancements in the diagnosis and treatment of this disorder. Intracranial aneurysm may be treated by microsurgical clipping or embolisation depending on its location and the surgeon's preference...
November 2016: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28088803/small-versus-large-ruptured-intracranial-aneurysm-concerns-with-the-site-of-aneurysm
#9
Bum Joon Kim, Hyun Goo Kang, Byeong-Duk Kwun, Jae-Sung Ahn, Jisung Lee, Sung Ho Lee, Dong-Wha Kang, Jong S Kim, Sun U Kwon
BACKGROUND: Although size is one of the strongest predictors, small aneurysms often rupture. We compared the characteristics of small and large ruptured intracranial aneurysms (RIAs) according to their location to find the factors associated with small RIAs in each location. METHODS: Patients with subarachnoid hemorrhage due to saccular RIAs were consecutively enrolled. The sizes were dichotomized as small (<5 mm) or large, and the location was classified as paraclinoid-distal internal carotid artery, sidewalls of anterior or middle cerebral artery (MCA; sidewall), MCA-bifurcation, anterior or posterior communicating artery (Acom or Pcom, respectively), and posterior circulation RIAs...
2017: Cerebrovascular Diseases
https://www.readbyqxmd.com/read/28011869/pcom-db-update-a-protein-co-migration-database-for-photosynthetic-organisms
#10
Atsushi Takabayashi, Saeka Takabayashi, Kaori Takahashi, Mai Watanabe, Hiroko Uchida, Akio Murakami, Tomomichi Fujita, Masahiko Ikeuchi, Ayumi Tanaka
The identification of protein complexes is important for the understanding of protein structure and function and the regulation of cellular processes. We used blue-native PAGE and tandem mass spectrometry to identify protein complexes systematically, and built a web database, the protein co-migration database (PCoM-DB, http://pcomdb.lowtem.hokudai.ac.jp/proteins/top), to provide prediction tools for protein complexes. PCoM-DB provides migration profiles for any given protein of interest, and allows users to compare them with migration profiles of other proteins, showing the oligomeric states of proteins and thus identifying potential interaction partners...
December 22, 2016: Plant & Cell Physiology
https://www.readbyqxmd.com/read/27987034/retrograde-suction-decompression-of-a-large-internal-carotid-aneurysm-using-a-balloon-guide-catheter-combined-with-a-blood-returning-circuit-and-sta-mca-bypass-a-technical-note
#11
Fumihiro Matano, Takayuki Mizunari, Shushi Kominami, Masanori Suzuki, Yu Fujiki, Asami Kubota, Shiro Kobayashi, Yasuo Murai, Akio Morita
It is difficult to treat large internal carotid aneurysms with simple surgical clipping. Here, we present a retrograde suction decompression (RSD) procedure for large internal carotid aneurysms using a balloon guide catheter combined with a blood-returning circuit and a superficial temporal artery to middle cerebral artery (STA-MCA) bypass.All patients underwent an STA-MCA bypass before the temporary occlusion of the internal carotid artery (ICA). A 6-French sheath was inserted into the common carotid artery (CCA), and a 6-French Patrive balloon catheter was placed into the ICA 5 cm past the bifurcation...
December 16, 2016: Neurosurgical Review
https://www.readbyqxmd.com/read/27899014/differentiation-between-polycystic-ovary-syndrome-and-polycystic-ovarian-morphology-by-means-of-an-anti-m%C3%A3-llerian-hormone-cutoff-value
#12
Do Kyeong Song, Jee-Young Oh, Hyejin Lee, Yeon-Ah Sung
Background/Aims: Although increased serum anti-Müllerian hormone (AMH) level has been suggested to be a surrogate marker of polycystic ovarian morphology (PCOM), its association with polycystic ovary syndrome (PCOS) is controversial, and its diagnostic value has not been determined. We aimed to observe the relationship between the AMH level and PCOS phenotypes and to determine the optimal cutoff value of AMH for the diagnosis of PCOS in young Korean women. Methods: We recruited 207 women with PCOS (120 with PCOM and 87 without PCOM) and 220 regular cycling women with normoandrogenemia (100 with PCOM and 120 without PCOM)...
November 30, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27833694/large-posterior-communicating-artery-aneurysm-initial-presentation-with-reproducible-facial-pain-without-cranial-nerve-deficit
#13
Stacie Zelman, Michael C Goebel, David E Manthey, Seth Hawkins
Unruptured posterior communicating artery (PCOM) aneurysms can be difficult to diagnose and, when large (≥ 7mm), represent a substantial risk to the patient. While most unruptured PCOM aneurysms are asymptomatic, when symptoms do occur, clinical manifestations typically include severe headache (HA), visual acuity loss, and cranial nerve deficit. This case report describes an atypical initial presentation of a large unruptured PCOM aneurysm with symptoms mimicking trigeminal neuralgia, without other associated cranial nerve palsies or neurologic deficits...
November 2016: Western Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27805276/anti-m%C3%A3-llerian-hormone-reflects-the-severity-of-polycystic-ovary-syndrome
#14
S L Jacob, H P Field, N Calder, H M Picton, A H Balen, J H Barth
OBJECTIVE: To examine the relationship between anti-Müllerian hormone (AMH) and the severity of the phenotype of patients with polycystic ovary syndrome (PCOS) and whether AMH can act as a diagnostic marker for PCOS? DESIGN: A prospective diagnostic utility study of AMH as a marker of PCOS. PATIENTS: A consecutive series of women presenting to a tertiary infertility clinic (n = 164) plus a second series of women prepared for assisted conception treatments (n = 89) recruited between June 2012 and May 2013...
March 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/27667792/detecting-subnetwork-level-dynamic-correlations
#15
Yan Yan, Shangzhao Qiu, Zhuxuan Jin, Sihong Gong, Yun Bai, Jianwei Lu, Tianwei Yu
MOTIVATION: The biological regulatory system is highly dynamic. The correlations between many functionally related genes change over different biological conditions. Finding dynamic relations on the existing biological network may reveal important regulatory mechanisms. Currently no method is available to detect subnetwork-level dynamic correlations systematically on the genome-scale network. Two major issues hampered the development. The first is gene expression profiling data usually do not contain time course measurements to facilitate the analysis of dynamic relations, which can be partially addressed by using certain genes as indicators of biological conditions...
January 15, 2017: Bioinformatics
https://www.readbyqxmd.com/read/27530062/phenotypes-and-body-mass-in-women-with-polycystic-ovary-syndrome-identified-in-referral-versus-unselected-populations-systematic-review-and-meta-analysis
#16
Daria Lizneva, Richard Kirubakaran, Kateryna Mykhalchenko, Larisa Suturina, Galina Chernukha, Michael P Diamond, Ricardo Azziz
OBJECTIVE: To compare the prevalence of polycystic ovary syndrome (PCOS) phenotypes and obesity among patients detected in referral versus unselected populations. DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): Thirteen thousand seven hundred ninety-six reproductive-age patients with PCOS, as defined by the extended Rotterdam 2003 criteria. INTERVENTION(S): Review of PUBMED, EMBASE, and Cochrane Library, 2003-2016...
November 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27513088/a-dismantling-study-of-the-partners-for-change-outcome-management-system
#17
RANDOMIZED CONTROLLED TRIAL
Cindy W Mikeal, J Arthur Gillaspy, Michael T Scoles, John J Murphy
The current study used a dismantling design to investigate the relative efficacy of components of the Partners for Change Outcome Management System (PCOMS; Duncan, 2012). Clients (n = 94) from a university counseling center were randomly assigned to 1 of 3 conditions: PCOMS Full, Outcome Rating Scale (ORS)-only, or Session Rating Scale (SRS)-only and nested within therapists (n = 12). Results from hierarchical linear modeling and a 2-way analysis of variance indicated no statistically significant differences in outcome or rate of change on the Behavior Symptom Checklist-18 (BSI-18; Derogatis, 2001) across all 3 conditions...
November 2016: Journal of Counseling Psychology
https://www.readbyqxmd.com/read/27510637/polycystic-ovary-syndrome
#18
REVIEW
Ricardo Azziz, Enrico Carmina, ZiJiang Chen, Andrea Dunaif, Joop S E Laven, Richard S Legro, Daria Lizneva, Barbara Natterson-Horowtiz, Helena J Teede, Bulent O Yildiz
Polycystic ovary syndrome (PCOS) affects 5-20% of women of reproductive age worldwide. The condition is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology (PCOM) - with excessive androgen production by the ovaries being a key feature of PCOS. Metabolic dysfunction characterized by insulin resistance and compensatory hyperinsulinaemia is evident in the vast majority of affected individuals. PCOS increases the risk for type 2 diabetes mellitus, gestational diabetes and other pregnancy-related complications, venous thromboembolism, cerebrovascular and cardiovascular events and endometrial cancer...
August 11, 2016: Nature Reviews. Disease Primers
https://www.readbyqxmd.com/read/27504851/steroid-metabolomic-disease-signature-of-nonsyndromic-childhood-obesity
#19
Aneta Gawlik, Michael Shmoish, Michaela F Hartmann, Ewa Malecka-Tendera, Stefan A Wudy, Ze'ev Hochberg
CONTEXT: The profile of urinary steroids as measured by gas chromatography-mass spectrometry defines a subject's "steroidal fingerprint." OBJECTIVE: Here, we clustered steroidal fingerprints to characterize patients with nonsyndromic childhood obesity by "steroid metabolomic signatures." HYPOTHESIS: Nonsyndromic obesity is a symptom of different diseases and conditions, some of them will have their own signature. DESIGN: A total of 31 steroid metabolites were quantified by gas chromatography-mass spectrometry, and their excretion rates were z-transformed...
November 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27473310/survey-of-chinese-medicine-students-to-determine-research-and-evidence-based-medicine-perspectives-at-pacific-college-of-oriental-medicine
#20
Belinda J Anderson, Benjamin Kligler, Hillel W Cohen, Paul R Marantz
CONTEXT: Research literacy and the practice of evidence-based medicine (EBM) are important initiatives in complementary and alternative medicine (CAM), which requires cultural change within educational institutions for successful implementation. OBJECTIVE: To determine the self-assessed research and EBM perspectives of Chinese medicine Masters degree students at Pacific College of Oriental Medicine, New York campus (PCOM-NY). DESIGN AND METHODS: A survey with 17 close-ended questions and one open-ended question was administered through Survey Monkey to students at PCOM-NY...
September 2016: Explore: the Journal of Science and Healing
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