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https://www.readbyqxmd.com/read/29457875/variations-of-the-circle-of-willis-at-the-end-of-the-human-embryonic-period
#1
Kana Furuichi, Aoi Ishikawa, Chigako Uwabe, Haruyuki Makishima, Shigehito Yamada, Tetsuya Takakuwa
Variations of the circle of Willis (CW) influence blood supply to the brain and adjacent structures in adults. We examined the formation of the CW in 20 human embryo samples at the end of the embryonic period using 3-D reconstructions of serial histological sections. The CW was closed in all samples, and did not form in a single plane, but was composed of multiple stair-like planes. The artery acutely curved at the caudal part of the CW, namely at the inlet of the basilar artery and bifurcation of the P1 segment of the posterior cerebral artery (PCA), reflecting flexure of the mesencephalon and diencephalon at this stage...
February 19, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29404254/contralateral-minimum-anterior-and-posterior-combined-petrosal-approach-for-retrochiasmatic-craniopharyngiomas-an-alternative-technique
#2
Sachin Ranganatha Goudihalli, Hiroki Morisako, Wimba Prastarana, Takeo Goto, Hiroki Ohata, Kenji Ohata
Retrochiasmatic craniopharyngiomas (RC) are a challenge for the neurosurgeon to treat surgically, restrained by their location in the interpeduncular fossa, surrounded by vital neurovascular structures, narrow corridor and poor visibility. Many approaches are possible and elucidated in the literature, which the surgeon chooses, based on multiple factors, such as the size of tumor, calcification, laterality, preoperative neurological deficits and the endocrine function status, recurrence, postradiotherapy status, or significant superior and/or posterior extension...
February 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29394920/occipital-lobe-infarction-a-rare-presentation-of-bilateral-giant-cavernous-carotid-aneurysms-a-case-report
#3
Kavin Vanikieti, Anuchit Poonyathalang, Panitha Jindahra, Piyaphon Cheecharoen, Wimonwan Chokthaweesak
BACKGROUND: Cavernous carotid aneurysm (CCA) represents 2-9% of all intracranial aneurysms and 15% of internal carotid artery (ICA) aneurysms; additionally, giant aneurysms are those aneurysms that are > 25 mm in size. Bilateral CCAs account for 11-29% of patients and are commonly associated with structural weaknesses in the ICA wall, secondary to systemic hypertension. CCAs are considered benign lesions, given the low risk for developing major neurologic morbidities (i.e., subarachnoid hemorrhage, cerebral infarction, or carotid cavernous fistula)...
February 2, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29370410/gut-microbial-diversity-in-women-with-polycystic-ovary-syndrome-correlates-with-hyperandrogenism
#4
Pedro J Torres, Martyna Siakowska, Beata Banaszewska, Leszek Pawelczyk, Antoni J Duleba, Scott T Kelley, Varykina G Thackray
Context: A majority of women with polycystic ovary syndrome (PCOS) have metabolic abnormalities that result in an increased risk of developing type 2 diabetes and heart disease. Correlative studies have shown an association between changes in the gut microbiome and metabolic disorders. Two recent studies reported a decrease in alpha diversity of the gut microbiome in women with PCOS compared with healthy women. Objective: We investigated whether changes in the gut microbiome correlated with specific clinical parameters in women with PCOS compared to healthy women...
January 23, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29340861/investigating-the-composition-characteristics-of-dissolved-and-particulate-colloidal-organic-matter-in-effluent-dominated-stream-using-fluorescence-spectroscopy-combined-with-multivariable-analysis
#5
Min-Da Yu, Xiao-Song He, Bei-Dou Xi, Ru-Tai Gao, Xian-Wei Zhao, Hui Zhang, Cai-Hong Huang, Wenbing Tan
Fluorescence excitation-emission matrix (EEM) spectroscopy combined with principal component analysis (PCA) and parallel factor analysis (PARAFAC) were used to investigate the compositional characteristics of dissolved and particulate/colloidal organic matter and its correlations with nitrogen, phosphorus, and heavy metals in an effluent-dominated stream, Northern China. The results showed that dissolved organic matter (DOM) was comprised of fulvic-like, humic-like, and protein-like components in the water samples, and fulvic-like substances were the main fraction of DOM among them...
January 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29289990/prevalence-clinical-characteristics-and-reproductive-outcomes-of-polycystic-ovary-syndrome-in-older-women-referred-for-tertiary-fertility-care
#6
Samer Tannus, Justin Tan, Weon-Young Son, Michael-Haim Dahan
OBJECTIVE: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. The clinical symptoms of PCOS vary with female age, as older women tend to have lower hyperandrogenic symptoms and many regain regular cycles. In this study, we aimed to estimate the prevalence of PCOS among older women referred for fertility care, describe their clinical characteristics, and compare their reproductive outcomes to those of matched control group. METHODS: A retrospective study conducted at a single reproductive center...
December 30, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29213291/apolipoprotein-e-polymorphism-and-the-risk-of-aneurysmal-subarachnoid-hemorrhage-in-a-south-indian-population
#7
Arati Suvatha, Sibin Madathan Kandi, Dhananjaya Ishwara Bhat, Narasinga Rao, Vikas Vazhayil, Chetan Ghati Kasturirangan
Background: The rupture of a brain aneurysm causes bleeding in the subarachnoid space. This is known as aneurysmal subarachnoid hemorrhage (aSAH). We evaluated the association of apolipoprotein E (APOE) polymorphism and the risk of aSAH in a South Indian population. Methods: The study was performed on 200 subjects with aSAH and 253 healthy control subjects. Blood samples (5 ml) were used to isolate DNA and genotyping was performed for rs7412 and rs429358 using a Taqman allelic discrimination assay...
2017: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29194016/assessment-of-occupational-exposure-to-asbestos-fibers-contribution-of-analytical-transmission-electron-microscopy-analysis-and-comparison-with-phase-contrast-microscopy
#8
Céline Eypert-Blaison, Anita Romero-Hariot, Frédéric Clerc, Raymond Vincent
From November 2009 until October 2010, the French general directorate for labour organised a large field-study using analytical transmission electron microscopy (ATEM) to characterise occupational exposure to asbestos fibers during work on asbestos containing materials (ACM). The primary objective of this study was to establish a method and to validate the feasibility of using ATEM for the analysis of airborne asbestos of individual filters sampled in various occupational environments. For each sampling event, ATEM data were compared to those obtained by phase-contrast optical microscopy (PCOM), the WHO-recommended reference technique...
December 1, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/29190387/chronic-hyperandrogenemia-in-the-presence-and-absence-of-a-western-style-diet-impairs-ovarian-and-uterine-structure-function-in-young-adult-rhesus-monkeys
#9
Cecily V Bishop, Emily C Mishler, Diana L Takahashi, Taylor E Reiter, Kise R Bond, Cadence A True, Ov D Slayden, Richard L Stouffer
STUDY QUESTION: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys? SUMMARY ANSWER: Phenotypic alterations in ovarian and uterine structure/function were induced by exogenous testosterone (T), and compounded in the presence of a WSD (T+WSD). WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of PCOS and is observed in adolescent girls, indicating a potential pubertal onset of disease symptoms...
November 28, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29184806/polycystic-ovary-syndrome-in-adolescence-diagnostic-and-therapeutic-strategies
#10
REVIEW
Manmohan K Kamboj, Andrea E Bonny
Controversy continues about the underlying etiopathogenesis, diagnostic criteria, and recommendations for polycystic ovary syndrome (PCOS) in adolescents. Recent literature has recognized these deficiencies and evidence based expert recommendations have become more available. The purpose of this chapter is to offer primary care providers a practical understanding and approach to the diagnosis and treatment of PCOS in adolescents. Although the presence of polycystic ovary morphology (PCOM) is included as a key diagnostic criterion of PCOS in adults, it is currently not recommended for the diagnosis in adolescents...
October 2017: Translational pediatrics
https://www.readbyqxmd.com/read/29172287/polycystic-ovarian-morphology-may-be-a-positive-prognostic-factor-in-patients-with-endometrial-cancer-who-achieved-complete-remission-after-fertility-sparing-therapy-with-progestin
#11
Yamato Fukui, Ayumi Taguchi, Katsuyuki Adachi, Marie Sato, Akira Kawata, Michihiro Tanikawa, Kenbun Sone, Mayuyo Mori, Kazunori Nagasaka, Yoko Matsumoto, Takahide Arimoto, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii
Background: The most studied fertility-sparing therapy for endometrial cancer (EC) is oral progestin therapy. However, complete remission (CR) rate after progestin therapy is not enough ranging from 60 to 80 %, with high recurrence rate. Clinical features that predict treatment efficacy and recurrence after progestin therapy have not yet been revealed in detail. The aim of this study was to investigate prognostic factors in patients with EC who achieved CR after medroxyprogesterone acetate (MPA) therapy. Methods: We retrospectively reviewed 35 EC patients treated with MPA at our institution between 2000 and 2016...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29118804/hybrid-retrograde-antegrade-recanalization-of-acute-basilar-artery-occlusion
#12
James D Rossen, Edgar A Samaniego, Mishelle Paullus, Santiago Ortega-Gutierrez
Acute basilar artery (BA) occlusion has a very poor prognosis. Recanalization can be challenged by bilateral vertebral artery (VA) occlusions, arterial dissection, or advanced atherosclerotic disease. We describe a case in whom the BA was accessed and recanalized through a retrograde-antegrade approach from the anterior circulation using a large posterior communicating artery (PCOM). Once the BA had been crossed retrogradely through the PCOM, another microcatheter was advanced antegradely through the VA into the BA and right posterior cerebral artery using the "buddy-wire" technique...
October 2017: Interventional Neurology
https://www.readbyqxmd.com/read/29114304/thrombosed-giant-true-posterior-communicating-artery-aneurysm-treated-by-trapping-and-thrombectomy
#13
Yuichi Mochizuki, Akitsugu Kawashima, Koji Yamaguch, Yoshikazu Okada
Giant "true" posterior communicating artery (PCOM) aneurysms are rare and the best surgical treatment for them is unclear. We present a case of 85-year-old woman with this type of lesion, 35 mm in diameter, successfully treated by trapping and thrombectomy via pterional approach without complications. There were no perforating arteries originating from the aneurysmal wall. The patient had an uneventful postoperative course. The key for successful treatment for such lesions is preservation of perforators, as trapping may result in ischemic complications...
October 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29103056/estimated-pretreatment-hemodynamic-prognostic-factors-of-aneurysm-recurrence-after-endovascular-embolization
#14
Kouichi Misaki, Hiroyuki Takao, Takashi Suzuki, Kengo Nishimura, Issei Kan, Ichiro Yuki, Toshihiro Ishibashi, Makoto Yamamoto, Yuichi Murayama
BACKGROUND: Hemodynamic factors play important roles in aneurysm recurrence after endovascular treatment. OBJECTIVE: Predicting the risk of recurrence by hemodynamic analysis using an untreated aneurysm model is important because such prediction is required before treatment. METHODS: We retrospectively analyzed hemodynamic factors associated with aneurysm recurrence from pretreatment models of five recurrent and five stable posterior communicating artery (Pcom) aneurysms with no significant differences in aneurysm volume, coil packing density, or sizes of the dome, neck, or Pcom...
October 23, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29096663/measuring-what-matters-to-rare-disease-patients-reflections-on-the-work-by-the-irdirc-taskforce-on-patient-centered-outcome-measures
#15
Thomas Morel, Stefan J Cano
Our ability to evaluate outcomes which genuinely reflect patients' unmet needs, hopes and concerns is of pivotal importance. However, much current clinical research and practice falls short of this objective by selecting outcome measures which do not capture patient value to the fullest. In this Opinion, we discuss Patient-Centered Outcomes Measures (PCOMs), which have the potential to systematically incorporate patient perspectives to measure those outcomes that matter most to patients. We argue for greater multi-stakeholder collaboration to develop PCOMs, with rare disease patients and families at the center...
November 2, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29049986/new-diagnostic-criteria-of-polycystic-ovarian-morphology-for-adolescents-impact-on-prevalence-and-hormonal-profile
#16
Paulina M Merino, Claudio Villarroel, Cristián Jesam, Patricia López, Ethel Codner
BACKGROUND: The ultrasonographic criteria used to identify polycystic ovarian morphology (PCOM) during adolescence have changed over time. Recently, a Worldwide Pediatric Consensus (PedC) defined PCOM using stricter criteria than the previous recommendations of the Rotterdam Consensus (RC) and Androgen Excess-Polycystic Ovarian Syndrome Society (AES/PCOS) criteria. The aim of this study was to determine the prevalence of PCOM in healthy adolescents according to the 3 reported diagnostic criteria and compare the hormonal profile in females with and without PCOM based on the PedC criteria...
2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28936194/the-siesta-habit-is-associated-with-a-decreased-risk-of-rupture-of-intracranial-aneurysms
#17
Huibin Kang, Xin Feng, Baorui Zhang, Erkang Guo, Luyao Wang, Zenghui Qian, Peng Liu, Xiaolong Wen, Wenjuan Xu, Youxiang Li, Chuhan Jiang, Zhongxue Wu, Hongbing Zhang, Aihua Liu
BACKGROUND: Previous studies have examined an association between the siesta habit and hypertension, as well as coronary heart disease. However, the relationship between a siesta and the risk of rupture of an intracranial aneurysm (IA) has not yet been established. We aimed to investigate the effects of a siesta on the risk of rupture of IAs. METHODS: We prospectively enrolled consecutive patients diagnosed with IAs at our hospital between January 2016 and December 2016...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28879505/recovery-of-oculomotor-nerve-palsy-after-endovascular-treatment-of-ruptured-posterior-communicating-artery-aneurysm
#18
Qing-Quan Zu, Xing-Long Liu, Bin Wang, Chun-Gao Zhou, Jin-Guo Xia, Lin-Bo Zhao, Hai-Bin Shi, Sheng Liu
PURPOSE: Oculomotor nerve palsy (ONP) may result from Posterior communicating artery (Pcom) aneurysms. Endovascular treatment of ruptured Pcom aneurysms generally is a safe procedure, but the effect of this therapy on ONP is incompletely elucidated. This retrospective study evaluates outcomes of ONP after endovascular treatment for ruptured Pcom aneurysm and with the intention to clarify predictors of recovery. METHODS: From May 2010 to October 2015, 210 patients with Pcom aneurysms underwent endovascular treatment at our institution...
November 2017: Neuroradiology
https://www.readbyqxmd.com/read/28875230/b-flow-sonography-for-evaluation-of-basal-cerebral-arteries-in-newborns
#19
M Groth, M Ernst, P Deindl, J Herrmann
The aim of the study was to evaluate the B‑flow sonography (BFS) to image the basal cerebral arteries in newborn infants. For this purpose 34 newborns, who underwent standardized ultrasound of the brain including BFS, color Doppler (CDS) and power Doppler (PDS) techniques were retrospectively assessed. Delineation of the anterior communicating (Acom), the posterior communicating (Pcom), the middle cerebral (M1 and M2 segments), the anterior cerebral (A1 and A2 segments), and the posterior cerebral artery (P1 and P2 segments) were visually scored...
September 5, 2017: Clinical Neuroradiology
https://www.readbyqxmd.com/read/28854589/use-of-the-serum-anti-m%C3%A3-llerian-hormone-assay-as-a-surrogate-for-polycystic-ovarian-morphology-impact-on-diagnosis-and-phenotypic-classification-of-polycystic-ovary-syndrome
#20
Alice Fraissinet, Geoffroy Robin, Pascal Pigny, Tiphaine Lefebvre, Sophie Catteau-Jonard, Didier Dewailly
STUDY QUESTION: Does the use of the serum anti-Müllerian hormone (AMH) assay to replace or complement ultrasound (U/S) affect the diagnosis or phenotypic distribution of polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Combining U/S and the serum AMH assay to define polycystic ovarian morphology (PCOM) diagnoses PCOS (according to the Rotterdam classification) in more patients than definitions using one or the other of these indicators exclusively. WHAT IS KNOWN ALREADY: Since 2003, PCOM, as defined by U/S, is one of the three diagnostic criteria for PCOS...
August 1, 2017: Human Reproduction
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