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Mesenchymal chondrosarcoma

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https://www.readbyqxmd.com/read/28271053/renal-extra-skeletal-mesenchymal-chondrosarcoma-a-case-report
#1
Mehdi Salehipour, Masood Hosseinzadeh, Afshin Molaei Sisakhti, Vahid Abdol Mohammadi Parvin, Amin Sadraei, Ali Adib
Primary mesenchymal chondrosarcoma of the Kidney is an extremely rare entity and very few cases have been reported in literature. We report a 22-year-old male with a right renal mass; after radical nephrectomy, pathologic examination revealed primary extra skeletal mesenchymal chondrosarcoma.
May 2017: Urology Case Reports
https://www.readbyqxmd.com/read/28258179/extraskeletal-orbital-mesenchymal-chondrosarcoma-surgical-approach-and-mini-review
#2
REVIEW
Ashish Jakhetiya, Nootan Kumar Shukla, Dillip Muduly, Shashank S Kale
Extraskeletal orbital mesenchymal chondrosarcoma (MC) is an extremely rare and highly aggressive tumour. It has characteristic radiological features and pathognomic histological biphasic pattern. Radical resection with negative margins is the mainstay of treatment; role of adjuvant chemotherapy and radiotherapy is yet not well defined. We report a rare case of 18-year-old man who was diagnosed to have orbital MC. He presented with locally advanced disease with no vision in the affected eye. He underwent right orbital exenteration; a transcranial intradural approach was used to divide the optic nerve, and the temporalis muscle flap was utilised to fill the exenterated orbit...
March 3, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28219175/-a-child-with-extraskeletal-mesenchymal-chondrosarcoma-in-nasal-cavity-and-sinus-a-case-report
#3
M Li, C B Guo, J Xing
No abstract text is available yet for this article.
February 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28164050/extraskeletal-mesenchymal-chondrosarcoma-of-shoulder-an-extremely-rare-case
#4
Salman Ghaffari, Ali Farsavian, Seyed Mohamad Mehdi Daneshpoor, Masoud Shayesteh Azar
INTRODUCTION: Extraskeletal chondrosarcoma (EMC) is a rare, aggressive neoplasm which has been seen in the soft tissue area. This soft tissue sarcoma is classified to myxoid and mesenchymal based on histologic criteria. The mesenchymal subtype has a poor prognosis. In approximately 50% of patient with EMC, we could observe soft tissue lesion and stippled calcification in the conventional radiography. CASE REPORT: In the current paper, we introduced a 47-year-old Iranian male patient having painless, mobile, nontender, and firm mass in left shoulder...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28112277/the-expression-of-sirt1-regulates-the-metastaticplasticity-of-chondrosarcoma-cells-by-inducing-epithelial-mesenchymal-transition
#5
Helin Feng, Jin Wang, Jianfa Xu, Congcong Xie, Fulu Gao, Zhiyong Li
SIRT1 belongs to the mammalian sirtuin family and plays an important role in deacetylating histone and nonhistone proteins. It is reported that SIRT1 is associated with tumor metastasis in several kinds of tumors. However, the effect of SIRT1 on the metastasis of chondrosarcoma cells is still unknown. In this study, we demonstrated that up and down-regulation of SIRT1 expression could significantly change the invasive and metastatic potential in chondrosarcoma cell line. Besides that, the result from the nude mice confirmed the effect of SIRT1 on metastasis of chondrosarcoma cells...
January 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28071641/epidemiological-data-and-case-load-spectrum-of-patients-presenting-to-bone-and-soft-tissue-disease-management-group-at-a-tertiary-cancer-center
#6
A Gulia, A Puri, S Chorge, P K Panda
INTRODUCTION AND BACKGROUND: This study was conducted to know the spectrum and number of bone and soft tissue (BST) tumors presenting to our institute. We needed to assess the gap between the number of patients seen and infrastructure available, and based on this information, help formulate guidelines for optimum utilization of resources and to provide best possible evidence-based cancer care. SETTINGS AND DESIGNS: This is a prospective observational study (epidemiological)...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28060373/small-round-blue-cell-tumors-of-the-sinonasal-tract-a-differential-diagnosis-approach
#7
Lester Dr Thompson
One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28042016/spontaneous-intraventricular-hemorrhage-a-rare-presentation-of-a-skull-base-mesenchymal-chondrosarcoma
#8
Altaf Ali Laghari, Gohar Javed, Muhammad Faheem Khan, Syed Ijlal Ahmed, Karim Rizwan Nathani, Riyasat Ahmed
BACKGROUND: Chondrosarcomas are very rare malignant, slow-growing tumors that develop in or near the petroclival region of the brain. We report a very rare case in which the tumor originated from left petrous bone and induced intraventricular hemorrhage leading to an acute comatose presentation. CASE DESCRIPTION: A 28-year-old man initially presented to the outpatient department with a 1-month history of headache, vomiting, vertigo, and left facial numbness. A lesion at the cerebellopontine angle with extension into the middle cranial fossa was demonstrated on computed tomography and magnetic resonance imaging...
March 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28000897/bortezomib-induces-apoptosis-and-suppresses-cell-growth-and-metastasis-by-inactivation-of-stat3-signaling-in-chondrosarcoma
#9
Xing Bao, Tingting Ren, Yi Huang, Chongmin Ren, Kang Yang, Hongliang Zhang, Wei Guo
Bortezomib, formerly known as PS341, is a novel proteasome inhibitor with in vitro and in vivo antineoplastic effects in many malignancies. However, diverse antitumor mechanisms of bortezomib have been identified in many investigations and preclinical studies. Understanding the molecular and cellular mechanisms through which bortezomib acts will improve the therapeutic utility of this drug in different cancer types. In the present study, we investigated the in vitro and in vivo effects of bortezomib on chondrosarcoma...
February 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/27900099/effect-of-cytostatic-proline-rich-polypeptide-1-on-tumor-suppressors-of-inflammation-pathway-signaling-in-chondrosarcoma
#10
Karina Galoian, Shihua Luo, Amir Qureshi, Parthik Patel, Rachel Price, Ashlyn S Morse, Gor Chailyan, Silva Abrahamyan, H T Temple
Cytokines produced in the tumour microenvironment exert an important role in cancer pathogenesis and in the inhibition of disease progression. Cancer of the cartilage is termed metastatic chondrosarcoma; however, the signaling events resulting in mesenchymal cell transformation to sarcoma have yet to be fully elucidated. The present study aimed to characterize the cytokine expression profile in the human JJ012 chondrosarcoma cell line, as well as the effect of cytostatic proline-rich polypeptide-1 (PRP-1). Western blot experiments demonstrated that the levels of suppressor of cytokine signaling 3 (SOCS3) were upregulated in chondrocytes compared with chondrosarcoma cells...
November 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27821242/-primary-ovarian-mesenchymal-chondrosarcoma-report-of-a-case
#11
Z Y Yue, D X Song, J Miao, H Wang, Y G Dong
No abstract text is available yet for this article.
November 8, 2016: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/27790706/clinical-outcomes-for-patients-after-surgery-and-radiation-therapy-for-mesenchymal-chondrosarcomas
#12
Karen De Amorim Bernstein, Norbert Liebsch, Yen-Lin Chen, Andrzej Niemierko, Joseph H Schwab, Kevin Raskin, Santiago A Lozano-Calderon, Gregory Cote, David C Harmon, Edwin Choy, Alex Haynes, John Mullen, Francis J Hornicek, Thomas F DeLaney
INTRODUCTION: We report the outcome of 23 patients with mesenchymal chondrosarcomas treated with surgery and radiation therapy +/- chemotherapy. The intent of the project was to review the impact of patient and treatment variables on treatment outcome, in particular with regard to extent of surgery and radiation dose. PATIENTS AND METHODS: Twenty-three patients with mesenchymal chondrosarcomas were treated with surgery and radiation therapy (min. dose 44 Gy; max...
December 2016: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27765044/bladder-chondrosarcoma-plus-urothelial-carcinoma-in-recurred-transitional-cell-carcinoma-of-the-upper-urinary-tract-a-case-report-and-literature-review
#13
Min Hyun Cho, Sung Han Kim, Weon Seo Park, Jae Young Joung, Ho Kyung Seo, Jinsoo Chung, Kang Hyun Lee
BACKGROUND: Sarcomatoid urothelial carcinoma (SUC) is a rare malignant neoplasm of the urinary bladder comprising 0.2-0.6 % of all histological bladder tumor subtypes. It presents as a high-stage malignancy and exhibits aggressive biological behavior, regardless of the treatment employed. It is defined as histologically indistinguishable from sarcoma and as a high-grade biphasic neoplasm with malignant epithelial and mesenchymal components. The mean age of patients presenting with SUC is 66 years, and the male-to-female ratio is 3:1...
October 20, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27756397/primary-alveolar-rhabdomyosarcoma-of-the-bone-two-cases-and-review-of-the-literature
#14
Petra Balogh, Rita Bánusz, Monika Csóka, Zsófia Váradi, Edit Varga, Zoltán Sápi
BACKGROUND: Rhabdomyosarcoma (RMS) is a malignant tumor of mesenchymal origin and comprises the largest category of soft-tissue sarcomas both in children and adolescents. From a pediatric oncology point of view, RMS has traditionally been classified into alveolar (ARMS) and embryonal (ERMS) subtypes. The anatomical localization of the tumor may vary, but commonly involve the head/neck regions, male and female urogenital tract or the trunk and extremities. CASE PRESENTATION: Here, we report two challenging cases involving 17- and 9-years-olds males where diffuse and multiplex bone lesions suggested either a hematological disease or a primary bone tumor (mesenchymal chondrosarcoma)...
October 18, 2016: Diagnostic Pathology
https://www.readbyqxmd.com/read/27721626/mesenchymal-chondrosarcoma-of-mandible
#15
Sumit Majumdar, Rajyalakshmi Boddepalli, Divya Uppala, A Kameswara Rao
Mesenchymal chondrosarcomas (MC) are rare and aggressive forms of chondrosarcoma. They are distinct tumors arising in unicentric or multicentric locations from both skeletal and extraskeletal tissues. The most affected region is the facial skeleton, especially the jaws. In this report, we present a case of MC primarily involving the mandible in a 60-year-old female patient.
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27703933/coexistence-of-extraskeletal-mesenchymal-chondrosarcoma-and-isolated-hemihyperplasia-a-case-report
#16
Nihat Demirhan Demirkiran, Olcay Akdeniz, Onur Hapa, Hasan Havıtçıoğlu
INTRODUCTION: Arthroscopic fixation of tibial spine fracture without damage to the growth plate is very important in patients with open physis. The present article describes a simple and effective technique being used for the first time to treat this condition. CASE REPORT: A 16-year-old boy sustained avulsion fractures of tibial spine while playing. He was treated arthroscopically with excellent result. CONCLUSION: Arthroscopic fixation of tibial spine fracture in patients with open physis with two cannulated screws perpendicular to each other is a very simple technique which provides strong construct, and allows early mobilization without risk of damage to the growth plate...
April 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/27639272/lhrh-receptor-expression-in-sarcomas-of-bone-and-soft-tissue
#17
Chenthuran Deivaraju, H Thomas Temple, Norman Block, Philip Robinson, Andrew V Schally
AIM: Luteinizing hormone releasing hormone (LHRH) is a neurohormone, secreted by the hypothalamus, which regulates the secretion of gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the pituitary. LHRH acts by binding to receptors located in the pituitary gland. These receptors (LHRH receptors) have also been found in the cytoplasm of many tumor cells that involve both the reproductive and non-reproductive organs. These receptors have been demonstrated in prostate and breast cancers, endometrial carcinomas, renal cell carcinoma, lymphoma, carcinoma of liver, pancreas and skin...
November 1, 2016: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/27617402/inhibition-of-bcl-2-family-members-sensitizes-mesenchymal-chondrosarcoma-to-conventional-chemotherapy-report-on-a-novel-mesenchymal-chondrosarcoma-cell-line
#18
Yvonne de Jong, Annemiek M van Maldegem, Adrian Marino-Enriquez, Danielle de Jong, Johnny Suijker, Inge H Briaire-de Bruijn, Alwine B Kruisselbrink, Anne-Marie Cleton-Jansen, Karoly Szuhai, Hans Gelderblom, Jonathan A Fletcher, Judith V M G Bovée
Mesenchymal chondrosarcomas are rare and highly aggressive sarcomas occurring in bone and soft tissue, with poor overall survival. Bcl-2 expression was previously shown to be upregulated in mesenchymal chondrosarcomas. We here report on a newly derived mesenchymal chondrosarcoma cell line, MCS170, in which we investigated treatment with the BH3 mimetic ABT-737 alone or in combination with conventional chemotherapy as a possible new therapeutic strategy. The presence of the characteristic HEY1-NCOA2 fusion was confirmed in the MCS170 cell line using FISH, RT-PCR, and sequencing...
October 2016: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27602960/endothelin-1-promotes-epithelial-mesenchymal-transition-in-human-chondrosarcoma-cells-by-repressing-mir-300
#19
Min-Huan Wu, Pei-Han Huang, Mingli Hsieh, Chun-Hao Tsai, Hsien-Te Chen, Chih-Hsin Tang
Chondrosarcoma is a malignant tumor of mesenchymal origin predominantly composed of cartilage-producing cells. This type of bone cancer is extremely resistant to radiotherapy and chemotherapy. Surgical resection is the primary treatment, but is often difficult and not always practical for metastatic disease, so more effective treatments are needed. In particular, it would be helpful to identify molecular markers as targets for therapeutic intervention. Endothelin-1 (ET-1), a potent vasoconstrictor, has been shown to enhance chondrosarcoma angiogenesis and metastasis...
October 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27600784/-lymph-node-metastasis-of-osteosarcomas
#20
REVIEW
N V Vasil'ev
Lymph node metastasis of osteosarcomas is a rather rare phenomenon; according to different authors, the incidence of lymph node metastasis is 4 to 11%. The detection of lymph node metastases in osteosarcoma is associated with a significant reduction in the 5-year survival of patients and allows its classification as clinical stage IV tumor. The risk factors for lymph node metastases in patients with bone sarcomas are age (≥64 years), gender (female), nosological entity (undifferentiated pleomorphic sarcoma, osteosarcoma, chondrosarcoma), tumor depth (muscle, bone), and the size of primary tumor (>5 сm)...
July 2016: Arkhiv Patologii
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