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Mesenchymal chondrosarcoma

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https://www.readbyqxmd.com/read/29783007/intracranial-mesenchymal-chondrosarcoma-report-of-16-cases
#1
Xiujian Ma, Ke Wang, Teng-Xian Guo, Liang Wang, Da Li, Shu-Yu Hao, Gui-Jun Jia, Wang Jia, Jun-Ting Zhang, Li-Wei Zhang, Zhen Wu
OBJECTIVES: Limited data about intracranial mesenchymal chondrosarcoma (MCS) are available. The goal of this study was to report the clinical characteristics, challenges in management and poor outcomes of intracranial MCS. METHODS: Clinical data of 16 patients with MCS were reviewed retrospectively to evaluate their clinical characteristics, management and outcomes. RESULTS: This study included 11 male and 5 female patients with a mean age of 22...
May 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29755276/primary-mesenchymal-chondrosarcoma-of-the-orbit-histopathological-report-of-3-pediatric-cases
#2
Hind M Alkatan, Charles G Eberhart, Khalid M Alshomar, Sahar M Elkhamary, Azza M Y Maktabi
Mesenchymal chondrosarcoma (MCS) is an unusual tumor mainly found in the skeleton. Around third of the cases occur in extra-skeletal sites with the orbit being the third most common site in these cases. In previous reviews of the orbital cases, it has been concluded that orbital MCS tends to occur in women in the second or third decades of life. However, 8 cases of orbital MCS have been reported so far in the pediatric age group (age less than 18 years-old) one of which has been considered congenital MCS in a 5-days old newborn girl...
January 2018: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/29721355/pituitary-fossa-chondrosarcoma-an-unusual-cause-of-a-sellar-suprasellar-mass-masquerading-as-pituitary-adenoma
#3
Gautam Dutta, Daljit Singh, Hukum Singh, Arvind Kumar Srivastava, Anita Jagetia, Deepashu Sachdeva
Background: Chondrosarcoma is a mesenchymal malignant tumor composed of tumor cells producing cartilage. It is more commonly found in older age group and usually affects the axial skeleton. Intracranial chondrosarcoma is extremely rare, and chondrosarcoma arising from the sellar region are even rarer with only a few cases described in the literature. We report a case of chondrosarcoma mimicking a sellar suprasellar mass with parasellar extension. Case Description: A 22-year old male presented with generalized intermittent headache along with diplopia and diminished visual acuity without any history of sexual dysfunction or galactorrhea...
2018: Surgical Neurology International
https://www.readbyqxmd.com/read/29682386/extraosseous-intradural-chondrosarcoma-of-the-cervical-spine-a-case-report-with-brief-review-of-literature
#4
Elizabeth Presutto, Sejal Patel, Joseph Fullmer, Sajeev Ezhapilli
Mesenchymal chondrosarcoma (MCS) is a malignant cancer of the cartilage that accounts for less than 1% of all chondrosarcomas and typically occurs within the bone. One-third of all mesenchymal chondrosarcomas are extraosseous soft tissue sarcomas, rendering this as an uncommon entity. We report a rare case of an extraosseous chondrosarcoma with the cervical spinal canal in a 21-year-old male. The purpose of this case report is to discuss the imaging characteristics of this pathology proven diagnosis.
2018: Case Reports in Radiology
https://www.readbyqxmd.com/read/29596896/minute-mesenchymal-chondrosarcoma-within-osteochondroma-an-unexpected-diagnosis-confirmed-by-hey1-ncoa2-fusion
#5
Shunichi Toki, Toru Motoi, Mototaka Miyake, Eisuke Kobayashi, Akira Kawai, Akihiko Yoshida
Mesenchymal chondrosarcoma is rare and can be challenging to diagnose. Herein, we report a minute mesenchymal chondrosarcoma within an osteochondroma. A 12-year-old girl presented with an asymptomatic exophytic lesion of the rib. The tumor was clinically diagnosed as osteochondroma, and was excised after observation for 3years. The resected specimen revealed an unexpected minute (0.9cm) "monophasic" mesenchymal chondrosarcoma in the apex of the lesion. The sarcoma consisted of monomorphic spindle cells without hyaline cartilage...
March 26, 2018: Human Pathology
https://www.readbyqxmd.com/read/29582189/mesenchymal-chondrosarcoma-a-review-with-emphasis-on-its-fusion-driven-biology
#6
REVIEW
Marc El Beaino, Jason Roszik, John A Livingston, Wei-Lien Wang, Alexander J Lazar, Behrang Amini, Vivek Subbiah, Valerae Lewis, Anthony P Conley
Mesenchymal chondrosarcoma is a rare but deadly form of chondrosarcoma that typically affects adolescents and young adults. While curative intent is possible for patients with localized disease, few options exist for patients in the unresectable/metastatic setting. Thus, it is imperative to understand the fusion-driven biology of this rare malignant neoplasm so as to lead to the future development of better therapeutics for this disease. This manuscript will briefly review the clinical and pathologic features of mesenchymal chondrosarcoma followed by an appraisal of existing data linked to the fusions, HEY1-NCOA2 and IRF2BP2-CDX1, and the associated downstream pathways...
March 26, 2018: Current Oncology Reports
https://www.readbyqxmd.com/read/29572501/array-based-dna-methylation-profiling-in-sarcomas-with-small-blue-round-cell-histology-provides-valuable-diagnostic-information
#7
Christian Koelsche, Wolfgang Hartmann, Daniel Schrimpf, Damian Stichel, Susanne Jabar, Andreas Ranft, David E Reuss, Felix Sahm, David T W Jones, Melanie Bewerunge-Hudler, Marcel Trautmann, Thomas Klingebiel, Christian Vokuhl, Manfred Gessler, Eva Wardelmann, Iver Petersen, Daniel Baumhoer, Uta Flucke, Cristina Antonescu, Manel Esteller, Stefan Fröhling, Marcel Kool, Stefan M Pfister, Gunhild Mechtersheimer, Uta Dirksen, Andreas von Deimling
Undifferentiated solid tumors with small blue round cell histology and expression of CD99 mostly resemble Ewing sarcoma. However, they also may include other tumors such as mesenchymal chondrosarcoma, synovial sarcoma, or small cell osteosarcoma. Definitive classification usually requires detection of entity-specific mutations. While this approach identifies the majority of Ewing sarcomas, a subset of lesions remains unclassified and, therefore, has been termed "Ewing-like sarcomas" or small blue round cell tumors not otherwise specified...
March 23, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29559236/mesenchymal-chondrosarcomas-showing-immunohistochemical-evidence-of-rhabdomyoblastic-differentiation-a-potential-diagnostic-pitfall
#8
Andrew L Folpe, Rondell P Graham, Anthony Martinez, David Schembri-Wismayer, Jennifer Boland, Karen J Fritchie
The diagnosis of mesenchymal chondrosarcoma, a distinctive biphasic malignant neoplasm harboring the HEY1-NCOA2 gene fusion and consisting of primitive round to spindled cells admixed with foci of relatively mature hyaline cartilage, is usually straightforward by morphological evaluation alone. However, in the setting of a limited biopsy, specimens lacking cartilage generate a broad differential diagnosis, encompassing a variety of other primitive sarcomas, including spindle cell/ sclerosing rhabdomyosarcoma...
March 17, 2018: Human Pathology
https://www.readbyqxmd.com/read/29361725/chondrosarcoma-a-rare-misfortune-in-aging-human-cartilage-the-role-of-stem-and-progenitor-cells-in-proliferation-malignant-degeneration-and-therapeutic-resistance
#9
REVIEW
Karen A Boehme, Sabine B Schleicher, Frank Traub, Bernd Rolauffs
Unlike other malignant bone tumors including osteosarcomas and Ewing sarcomas with a peak incidence in adolescents and young adults, conventional and dedifferentiated chondrosarcomas mainly affect people in the 4th to 7th decade of life. To date, the cell type of chondrosarcoma origin is not clearly defined. However, it seems that mesenchymal stem and progenitor cells (MSPC) in the bone marrow facing a pro-proliferative as well as predominantly chondrogenic differentiation milieu, as is implicated in early stage osteoarthritis (OA) at that age, are the source of chondrosarcoma genesis...
January 21, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29342030/mesenchymal-chondrosarcoma-of-the-lacrimal-gland
#10
Hayyam Kiratli, Yağmur Deniz, Berrin Büyükeren, Gökhan Gedikoğlu
A 23-year-old woman presented with right-sided painless proptosis that developed in 12 months. MRI studies demonstrated a well-delineated tumorous enlargement of the right lacrimal gland with homogenous signal intensity and compressing the globe. The tumor was removed totally and in 1 piece with the tentative diagnosis of a pleomorphic adenoma. Pathologic examination revealed biphasic neoplastic elements, which were composed of the cartilaginous matrix and small round cell component. Immunohistopathological examination showed positive CD99 staining and negative reaction to S100, panCK, and CD15...
January 16, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29339836/the-role-of-metabolic-enzymes-in-mesenchymal-tumors-and-tumor-syndromes-genetics-pathology-and-molecular-mechanisms
#11
REVIEW
Inga-Marie Schaefer, Jason L Hornick, Judith V M G Bovée
The discovery of mutations in genes encoding the metabolic enzymes isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (FH) has expanded our understanding not only of altered metabolic pathways but also epigenetic dysregulation in cancer. IDH1/2 mutations occur in enchondromas and chondrosarcomas in patients with the non-hereditary enchondromatosis syndromes Ollier disease and Maffucci syndrome and in sporadic tumors. IDH1/2 mutations result in excess production of the oncometabolite (D)-2-hydroxyglutarate...
January 16, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29332118/primary-extraskeletal-mesenchymal-chondrosarcoma-arising-from-the-iliac-vein
#12
Mahmood D Al-Mendalawi
[No Abstract Available].
January 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29327709/insm1-expression-and-its-diagnostic-significance-in-extraskeletal-myxoid-chondrosarcoma
#13
Akihiko Yoshida, Naohiro Makise, Susumu Wakai, Akira Kawai, Nobuyoshi Hiraoka
Extraskeletal myxoid chondrosarcoma is a rare subtype of sarcoma that affects the soft tissue and bones in middle-aged and elderly adults. Its diagnosis can be challenging, with the differential diagnoses including a wide variety of mesenchymal tumors. The line of differentiation of extraskeletal myxoid chondrosarcoma has been controversial, but recent evidence suggests a neuroendocrine phenotype. INSM1 is a zinc-finger transcription factor that plays a pivotal role in neuroendocrine differentiation, and has been proposed as a promising immunohistochemical marker of neuroendocrine carcinoma...
January 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29238848/biology-of-bone-sarcomas-and-new-therapeutic-developments
#14
REVIEW
Hannah K Brown, Kristina Schiavone, François Gouin, Marie-Françoise Heymann, Dominique Heymann
Bone sarcomas are tumours belonging to the family of mesenchymal tumours and constitute a highly heterogeneous tumour group. The three main bone sarcomas are osteosarcoma, Ewing sarcoma and chondrosarcoma each subdivided in diverse histological entities. They are clinically characterised by a relatively high morbidity and mortality, especially in children and adolescents. Although these tumours are histologically, molecularly and genetically heterogeneous, they share a common involvement of the local microenvironment in their pathogenesis...
February 2018: Calcified Tissue International
https://www.readbyqxmd.com/read/29230266/-shoulder-tumor-of-startling-appearance
#15
Ilhame Naciri, Baderddine Hassam
Chondrosarcoma is a malignant tumor of bone of mesenchymal origin which usually occurs in people after age 40 at the level of the pelvis and the shoulder. We report the case of a 65-year old female patient, with no particular past medical history, with impaired general condition, hospitalized for exploration of a large tumor of the right shoulder, evolving over 3 years. Clinical examination showed giant, humpbacked, hard, adherent tumor measuring 44 × 32 cm along its longer axis, with inflammatory signs associated with signs of vasculo-nervous compression...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29229475/a-huge-mass-in-a-boy-s-chest-an-unusual-case-of-mesenchymal-chondrosarcoma
#16
Min Li, Rongchun Wang, Zhuang Luo
No abstract text is available yet for this article.
December 8, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/29215408/18f-fdg-pet-ct-findings-of-mesenchymal-chondrosarcoma-of-the-orbit
#17
Mitsuteru Tsuchiya, Takayuki Masui, Yoshiro Otsuki, Harumi Sakahara
Mesenchymal chondrosarcoma of the orbit is an extremely rare and aggressive tumor. We report image findings of F-fluorodeoxyglucose (FDG) positron emission/computed tomography (PET/CT) in 2 cases, one primary case and one recurrent case. The F-FDG PET/CT images revealed high uptake with an SUVmax of 6.7 and 11.7, respectively. In both cases, the HEY1-CoA2 gene fusion was positive. The high uptake of F-FDG in mesenchymal chondrosarcoma of the orbit well suggests the malignancy of this tumor.
February 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29160138/a-case-of-dedifferentiated-chondrosarcoma-arising-in-the-cricoid-cartilage-that-mimicked-an-aneurysmal-bone-cyst
#18
Lixiao Chen, Ziwei Yu, Rui Jiang, Pin Dong, Bin Shen, Yu Li
Dedifferentiated chondrosarcoma of the larynx is a rare and highly malignant tumor. We present the report of a 59-year-old man with dedifferentiated laryngeal chondrosarcoma, which was difficult to diagnose even under microscopic examination. The original diagnosis was an aneurysmal bone cyst, and the final diagnosis was established only after careful consideration of the imaging, surgical, and microscopic findings. In clinical practice, there are many similarities between dedifferentiated chondrosarcoma and aneurysmal bone cysts...
March 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29143958/intraspinal-mesenchymal-chondrosarcoma-report-of-a-pediatric-case-and-literature-review
#19
Angela Di Giannatale, Marta Colletti, Ida Russo, Valentina Ferruzzi, Vito Andrea Dell' Anna, Raffaele Cozza, Giovanna Stefania Colafati, Raffaella Messina, Angela Mastronuzzi, Rita De Vito, Giuseppe Maria Milano
PURPOSE: Mesenchymal chondrosarcoma (MCS) is an aggressive variant of chondrosarcoma and is a rare tumor, particularly within the pediatric population. Commonly, MCS originates in the bone, but it can also arise in extraskeletal sites, such as the brain and the intraspinal area. Due to the rarity of this tumor, there are no guidelines for its optimal treatment. METHODS: We report a case of intradural extramedullary MCS, located at the T11-T12 level, in a 14-year-old male...
November 15, 2017: Tumori
https://www.readbyqxmd.com/read/29044531/mesenchymal-chondrosarcoma-a-japanese-musculoskeletal-oncology-group-jmog-study-on-57-patients
#20
Yusuke Tsuda, Koichi Ogura, Michiyuki Hakozaki, Kazutaka Kikuta, Keisuke Ae, Hiroyuki Tsuchiya, Shintaro Iwata, Takafumi Ueda, Hirotaka Kawano, Akira Kawai
BACKGROUND: This study aimed to elucidate the clinical features and prognostic factors of mesenchymal chondrosarcoma (MCS) and investigate optimal treatment strategies. METHODS: Data from 57 patients with MCS were collected from a Japanese Musculoskeletal Oncology Group (JMOG) and retrospectively analyzed. RESULTS: Data from 29 males and 28 females were collected. Primary tumor sites were the head and neck (7 patients), trunk (35 patients), and extremities (15 patients)...
May 2017: Journal of Surgical Oncology
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