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https://www.readbyqxmd.com/read/28327550/significant-role-of-collagen-xvii-and-integrin-%C3%AE-4-in-migration-and-invasion-of-the-less-aggressive-squamous-cell-carcinoma-cells
#1
Jyri M Moilanen, Stefanie Löffek, Nina Kokkonen, Sirpa Salo, Juha P Väyrynen, Tiina Hurskainen, Aki Manninen, Pilvi Riihilä, Ritva Heljasvaara, Claus-Werner Franzke, Veli-Matti Kähäri, Tuula Salo, Markus J Mäkinen, Kaisa Tasanen
Collagen XVII and integrin α6β4 have well-established roles as epithelial adhesion molecules. Their binding partner laminin 332 as well as integrin α6β4 are largely recognized to promote invasion and metastasis in various cancers, and collagen XVII is essential for the survival of colon and lung cancer stem cells. We have studied the expression of laminin γ2, collagen XVII and integrin β4 in tissue microarray samples of squamous cell carcinoma (SCC) and its precursors, actinic keratosis and Bowen's disease...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28290742/patients-beliefs-about-the-causes-of-myomas-a-pilot-study-from-a-large-european-city
#2
Matthias David, Miriam Alpheus, Heribert Kentenich
INTRODUCTION: Patients usually develop subjective concepts about their illness, which then influences their further health behaviors and treatment decisions. This study aimed to evaluate several possible patient beliefs about the causal factors of illness, in a large sample of women seeking treatment for myomas. METHODS: From November 2011 to October 2013, all patients at a specialized myoma clinic in a large European city were surveyed about their beliefs about the causes of myomas...
March 14, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28267814/safety-after-extended-repeated-use-of-ulipristal-acetate-for-uterine-fibroids
#3
Bart C J M Fauser, Jacques Donnez, Philippe Bouchard, David H Barlow, Francisco Vázquez, Pablo Arriagada, Sven O Skouby, Santiago Palacios, Janusz Tomaszewski, Boguslaw Lemieszczuk, Alistair R W William
OBJECTIVE: To assess long term safety of extended repeated 3-month courses of ulipristal acetate (UPA) 10 mg/day, for up to 8 courses, with focus on endometrial and laboratory safety parameters. METHODS: This long-term, multi-center, open-label cohort, follow up study consisted of up to 8 consecutive 3-month courses of daily UPA 10 mg, each separated by a drug free period of 2 spontaneous menstrual bleeds. Sixty-four pre-menopausal women, with moderate to severe symptomatic uterine myoma(s) and heavy bleeding were enrolled and were studied for approximately 4 years...
2017: PloS One
https://www.readbyqxmd.com/read/28260688/suturing-method-as-a-factor-for-uterine-vascularity-after-laparoscopic-myomectomy
#4
Akihisa Fujimoto, Chieko Morimoto, Yumi Hosokawa, Akiko Hasegawa
OBJECTIVE: To evaluate the vascularity of the myometrium after laparoscopic myomectomy sutured by two different methods using contrast-enhanced Magnetic Resonance Imaging. STUDY DESIGN: Twenty-eight women who had symptomatic leiomyomas and underwent laparoscopic myomectomy between June 2013 and July 2014 were included in the present study. In the first half period, continuous sutures were used in 12 patients, and in the latter half period, single interrupted sutures were used in 16 patients...
February 28, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28250723/ulipristal-acetate-before-high-complexity-endoscopic-hysteroscopic-laparoscopic-myomectomy-a-mini-review
#5
REVIEW
Włodzimierz Baranowski
Uterine myomas (fibromas, leiomyomas) are the most common tumours in women, and their clinical signs and symptoms are presented by 25-40% of patients with these benign tumours. According to current guidelines, the armamentarium for myoma management consists of: medical therapy (GnRH, SPRMs), non-surgical alternatives including uterine artery embolisation (UAE), vaginal temporary occlusion of uterine arteries using clamp-like device or MRgFUS technique, and surgical treatment (including minimally invasive techniques)...
December 2016: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28242959/is-laparoscopic-power-morcellation-of-fibroids-a-cardinal-sin-in-2017
#6
EDITORIAL
Gautam N Allahbadia
The diagnosis of an unsuspected leiomyosarcoma after hysterectomy for the treatment of a presumed benign leiomyoma is a rare but highly clinically significant event. In order to facilitate removal of large uterine specimens using a minimally invasive surgical approach, morcellation with extraction in pieces is often performed. In the event of unsuspected malignancy, this may result in abdominal dispersion of the tumor and contribute to poorer survival. Modern surgical innovations always work toward improving minimally invasive strategies...
February 2017: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/28217668/endometrial-polyp-surveillance-in-premenopausal-breast-cancer-patients-using-tamoxifen
#7
Se Jeong Jeon, Jae Il Lee, Maria Lee, Hee Seung Kim, Jae Weon Kim, Noh Hyun Park, Yong Sang Song
OBJECTIVE: To describe the endometrial pathologic lesions in premenopausal breast cancer patients with a history of tamoxifen (TMX) use. METHODS: We retrospectively reviewed the medical records of 120 premenopausal breast cancer patients with a history of TMX use that had undergone a gynecological examination. RESULTS: Among 120 patients, 44.2% (n=53) were asymptomatic with an endometrial thickness ≥5 mm, as assessed by transvaginal ultrasonography...
January 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28215514/robotic-single-site-myomectomy-clinical-analysis-of-61consecutive-cases
#8
Eun Ji Choi, A Mi Rho, Sa Ra Lee, Kyungah Jeong, Hye-Sung Moon
STUDY OBJECTIVE: To report 61 consecutive cases of successful robotic single-site myomectomy(RSSM) and to evaluate the feasibility and safety of RSSM. DESIGN: Retrospective analysis of 61 cases of RSSM DESIGN: Classification: Canadian Task Force classification III SETTING: Department of Obstetrics and Gynecology, School of Medicine, Robot Surgery Center, Ewha Womans University PATIENTS: 61 patients who had RSSM INTERVENTIONS: Patients underwent RSSM by 3 gynecologic surgeons at Ewha Womans University Medical Center from December 2014 to May 2016...
February 12, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28210025/vascular-lipoleiomyoma-of-the-uterus-an-unusual-case
#9
Vesna Chibisheva, Vesna Antovska, Milka Trajanova, Drage Dabeski, Rubens Jovanovic, Ivana Kijajova
INTRODUCTION: Uterine lipoleiomyomas are a rare type of uterine myomas, which have been seldom diagnosed and are less known and still unusual. Histologically they are composed of smooth muscle cells with multiple fat cells and fibrous tissue. Their pathogenesis is still a stigmata and their preoperative diagnosis is still questionable. CASE REPORT HISTORY: A 39-year old woman presented at the University clinic for obstetrics and gynecology with complaints of a mild low abdominal and pelvic pain, increased frequency of vaginal bleeding and abdominal distension...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28203626/diffuse-peritoneal-leiomyomatosis-status-post-laparoscopic-hysterectomy-with-power-morcellation-a-case-report-with-review-of-literature
#10
Don Nguyen, Rishi Maheshwary, Cassie Tran, Scott Rudkin, Luke Treaster
•Leiomyomatosis following laparoscopic hysterectomy with morcellation is reported.•Parasitic myomas grow in a benign fashion but may be fatal depending on location.•Fibroids are a contraindication for laparoscopic hysterectomy with morcellation.•Containment bags may address intraperitoneal spillage of malignant tissue.
February 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28174410/-benign-metastasizing-leiomyoma-of-the-lung-report-of-a-case
#11
Takahiro Sawada, Satoshi Yamamoto, Hajime Sugihara, Akinori Iwasaki
A 71-year-old woman, in whom computed tomography revealed a solitary mass shadow at the base of the left lung, underwent resection of the mass. Histopathological examination showed estrogen receptor-positive leiomyoma cells growing in cords and mixed with glandular structures composed of alveolar cells. These findings led to a diagnosis of benign metastatic leiomyoma. Benign metastatic leiomyoma is a rare disease in which histologically benign uterine leiomyoma cells metastasize to different sites of the body...
February 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/28168805/cesarean-myomectomy-in-modern-obstetrics-more-light-and-fewer-shadows
#12
REVIEW
Radmila Sparić, Saša Kadija, Aleksandar Stefanović, Svetlana Spremović Radjenović, Ivana Likić Ladjević, Jela Popović, Andrea Tinelli
The study aim was to evaluate management of myomas during cesarean section, the pro and cons and the outcomes of cesarean myomectomy. Moreover, we tried to investigate the long-term outcomes of cesarean myomectomy. The authors conducted a literature review using scientific databases, focusing on the benefits and outcomes of cesarean myomectomy and the recent trends regarding this topic, and identified relevant articles, related references and other papers citing them. Despite the demonstrated advantages of cesarean myomectomy, postponed myomectomy after cesarean section was recommended in some instances...
February 7, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28159054/long-term-sequelae-of-unconfined-morcellation-during-laparoscopic-gynecological-surgery
#13
REVIEW
Aviad Cohen, Togas Tulandi
Although rare, unconfined morcellation of occult sarcoma has been associated with reduced survival rates. Morcellation of uterus and myoma can also lead to iatrogenic endometriosis, parasitic myoma and, albeit rarely, disseminated peritoneal leiomyomatosis. These benign sequelae of morcellation occur more often than malignant dissemination of sarcomatous tissue. Accordingly, confined morcellation should be performed with a minimally invasive technique while eliminating tissue dissemination inside the abdominal cavity...
March 2017: Maturitas
https://www.readbyqxmd.com/read/28121646/minimally-invasive-myomectomy
#14
Rebecca Flyckt, Kathryn Coyne, Tommaso Falcone
Uterine fibroids can significantly impact a woman's health, fertility, and quality of life. When medical therapy fails, surgery is recommended; the gold standard in uterine-sparing surgery is myomectomy. The evidence-based benefits of minimally invasive myomectomy are detailed in this manuscript. Minimally invasive myomectomy techniques are reviewed, including laparoscopic, robotic-assisted, and laparoscopic or robotic-assisted with mini-laparotomy. Criteria for minimally invasive myomectomy are outlined and preoperative planning is discussed...
January 24, 2017: Clinical Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28104498/laparoscopic-myomectomy-a-single-centre-retrospective-review-of-514-patients
#15
Elisabeth Mary Ruth Bean, Alfred Cutner, Tom Holland, Arvind Vashisht, Davor Jurkovic, Ertan Saridogan
STUDY OBJECTIVE: To review surgical outcomes and histopathological findings following laparoscopic myomectomy by a team at a university teaching hospital. DESIGN: This was a retrospective review of consecutive cases of laparoscopic myomectomy carried out by members of our minimal access surgery team between January 2004 and December 2015. DESIGN CLASSIFICATION: Canadian Task Force Classification II-3 SETTING: University Teaching Hospital PATIENTS: Women undergoing laparoscopic myomectomy INTERVENTIONS: Laparoscopic myomectomy MEASUREMENTS AND MAIN RESULTS: We collected women's demographic data, clinical histories and surgical outcomes, including complication rates and the incidence of undiagnosed uterine malignancy...
January 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28089570/use-of-augmented-reality-in-laparoscopic-gynecology-to-visualize-myomas
#16
Nicolas Bourdel, Toby Collins, Daniel Pizarro, Clement Debize, Anne-Sophie Grémeau, Adrien Bartoli, Michel Canis
OBJECTIVE: To report the use of augmented reality (AR) in gynecology. DESIGN: AR is a surgical guidance technology that enables important hidden surface structures to be visualized in endoscopic images. AR has been used for other organs, but never in gynecology and never with a very mobile organ like the uterus. We have developed a new AR approach specifically for uterine surgery and demonstrated its use for myomectomy. SETTING: Tertiary university hospital...
March 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28076829/comparing-the-effect-of-aromatase-inhibitor-letrozole-cabergoline-dostinex-and-letrozole-alone-on-uterine-myoma-regression-a-randomized-clinical-trial
#17
M Sayyah-Melli, M Mobasseri, P M Gharabaghi, E Ouladsahebmadarek, V Rahmani
OBJECTIVE: To evaluate the effect of letrozole in combination with cabergoline and letrozole alone on regression of symptomatic uterine myomas in women of reproductive age. DESIGN: Randomized controlled clinical trial. SETTING: University hospital. PATIENTS: Ninety-one women of reproductive age were enrolled in the study and 88 women were eligible. Eight participants were excluded from the study. INTERVENTIONS: Eighty women of reproductive age with symptomatic myomas >4cm were evaluated in two groups...
December 23, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28069179/rewriting-the-script-time-to-rethink-the-indications-for-myoma-surgery
#18
EDITORIAL
Jacques Donnez, Olivier Donnez, Marie-Madeleine Dolmans
No abstract text is available yet for this article.
February 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28064548/amniotic-fluid-sludge-prevalence-and-clinical-significance-of-it-in-asymptomatic-patients-at-high-risk-for-spontaneous-preterm-delivery
#19
Ilknur Adanir, Ozgur Ozyuncu, Ayse Filiz Gokmen Karasu, Lutfu S Onderoglu
INTRODUCTION: The aim of our study is to determine prevalence and clinical significance of the presence of amniotic fluid "sludge" among asymptomatic patients at high-risk for spontaneous preterm delivery, prospectively. MATERIAL AND METHODS: In our study, 99 patients at high risk for spontaneous preterm delivery were evaluated for the presence of amniotic fluid sludge with transvaginal ultrasonography at 20-22, 26-28, and 32-34 gestational weeks, prospectively; between August 2009 and October 2010 in Hacettepe University Hospital...
January 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28049197/venous-air-embolism-during-hysteroscopic-myomectomy-an-analysis-of-7-cases
#20
Cédric Van Dijck, Steffen Rex, Jasper Verguts, Dirk Timmerman, Marc Van de Velde, An Teunkens
Venous air embolism (VAE) is a rare but potentially fatal complication of hysteroscopic myomectomy. The symptoms of VAE range from mild and clinically insignificant to complete cardiovascular collapse during surgery. Anesthesiologists and surgeons should be aware of the clinical characteristics and predisposing factors of this possible adverse event. This report analyzes 7 cases of VAE, which occurred at the University Hospitals Leuven, in patients undergoing hysteroscopic myomectomy from April 2009 to April 2011...
January 4, 2017: Gynecologic and Obstetric Investigation
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