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Skeletal muscle damage

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https://www.readbyqxmd.com/read/28435079/polyurethane-acrylates-as-effective-substrates-for-sustained-in-vitro-culture-of-human-myotubes
#1
Yosephine Andriani, Jason Chua Min-Wen, Benjamin Chua Yan-Jiang, Phang In Yee, Ng Shyh-Chang, Tan Wui Siew
Muscular disease has debilitating effects with severe damage leading to death. Our knowledge of muscle biology, disease and treatment is largely derived from non human cell models, even though non human cells are known to differ from human cells in their biochemical responses. Attempts to develop highly sought after in vitro human cell models have been plagued by early cell delamination and difficulties in achieving human myotube culture in vitro. In this work, we developed polyurethane acrylate (PUA) materials to support long term in vitro culture of human skeletal muscle tissue...
April 20, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28432755/mitochondria-and-ageing-role-in-heart-skeletal-muscle-and-adipose-tissue
#2
REVIEW
Kerstin Boengler, Maik Kosiol, Manuel Mayr, Rainer Schulz, Susanne Rohrbach
Age is the most important risk factor for most diseases. Mitochondria play a central role in bioenergetics and metabolism. In addition, several lines of evidence indicate the impact of mitochondria in lifespan determination and ageing. The best-known hypothesis to explain ageing is the free radical theory, which proposes that cells, organs, and organisms age because they accumulate reactive oxygen species (ROS) damage over time. Mitochondria play a central role as the principle source of intracellular ROS, which are mainly formed at the level of complex I and III of the respiratory chain...
April 21, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28425943/beneficial-effect-of-voluntary-exercise-on-experimental-colitis-in-mice-fed-a-high-fat-diet-the-role-of-irisin-adiponectin-and-proinflammatory-biomarkers
#3
Agnieszka Irena Mazur-Bialy, Jan Bilski, Dagmara Wojcik, Bartosz Brzozowski, Marcin Surmiak, Magdalena Hubalewska-Mazgaj, Anna Chmura, Marcin Magierowski, Katarzyna Magierowska, Tomasz Mach, Tomasz Brzozowski
Inflammatory bowel diseases (IBDs) are a heterogeneous group of disorders exhibited by two major phenotypic forms: Crohn's disease and ulcerative colitis. Although the aetiology of IBD is unknown, several factors coming from the adipose tissue and skeletal muscles, such as cytokines, adipokines and myokines, were suggested in the pathogenesis of ulcerative colitis; however, it has not been extensively studied whether voluntary exercise can ameliorate that disorder. We explored the effect of moderate exercise (i...
April 20, 2017: Nutrients
https://www.readbyqxmd.com/read/28425181/effects-of-different-aerobic-exercise-frequencies-on%C3%A2-streptozotocin-nicotinamide-induced-type-2-diabetic-rats-continuous-versus-short-bouts-and-weekend-warrior-exercises
#4
Nuray Alaca, Serap Uslu, Guldal Gulec Suyen, Umit Ince, Mustafa Serteser, Hızır Kurtel
BACKGROUND: Exercise training is known to exert multiple beneficial effects on type 2 diabetes mellitus (T2DM). In this study, we aimed at exploring the effects of aerobic exercise frequencies on diabetic parameters, the histopathological structure of skeletal muscle, diabetic myopathy and mitochondrial enzyme activities in an experimental model of T2DM. METHODS: T2DM was induced by using nicotinamide (110 mg/kg) and streptozotocin (65 mg/kg) in Sprague Dawley rats (n: 35)...
April 20, 2017: Journal of Diabetes
https://www.readbyqxmd.com/read/28423313/power-grid-protection-of-the-muscle-mitochondrial-reticulum
#5
Brian Glancy, Lisa M Hartnell, Christian A Combs, Armel Fenmou, Junhui Sun, Elizabeth Murphy, Sriram Subramaniam, Robert S Balaban
Mitochondrial network connectivity enables rapid communication and distribution of potential energy throughout the cell. However, this connectivity puts the energy conversion system at risk, because damaged elements could jeopardize the entire network. Here, we demonstrate the mechanisms for mitochondrial network protection in heart and skeletal muscle (SKM). We find that the cardiac mitochondrial reticulum is segmented into subnetworks comprising many mitochondria linked through abundant contact sites at highly specific intermitochondrial junctions (IMJs)...
April 18, 2017: Cell Reports
https://www.readbyqxmd.com/read/28420091/dietary-sugars-and-endogenous-formation-of-advanced-glycation-endproducts-emerging-mechanisms-of-disease
#6
REVIEW
Manuela Aragno, Raffaella Mastrocola
The rapid increase in metabolic diseases, which occurred in the last three decades in both industrialized and developing countries, has been related to the rise in sugar-added foods and sweetened beverages consumption. An emerging topic in the pathogenesis of metabolic diseases related to modern nutrition is the role of Advanced Glycation Endproducts (AGEs). AGEs can be ingested with high temperature processed foods, but also endogenously formed as a consequence of a high dietary sugar intake. Animal models of high sugar consumption, in particular fructose, have reported AGE accumulation in different tissues in association with peripheral insulin resistance and lipid metabolism alterations...
April 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28419894/muscle-cell-communication-in-development-and-repair
#7
REVIEW
Alexis R Demonbreun, Elizabeth M McNally
Under basal conditions, postnatal skeletal muscle displays little cell turnover. With injury, muscle initiates a rapid repair response to reseal damaged membrane, reactivating many developmental pathways to facilitate muscle regeneration and prevent tissue loss. Muscle precursor cells become activated accompanied by differentiation and fusion during both muscle growth and regeneration; inter-cellular communication is required for successful completion of these processes. Cellular communication is mediated by lipids, fusogenic membrane proteins, and exosomes...
April 15, 2017: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/28417082/improving-glucose-tolerance-by-muscle-damaging-exercise
#8
Chien-Te Ho, Machiko Otaka, Chia-Hua Kuo
Tissue damage is regarded as an unwanted medical condition to be avoided. However, introducing tolerable tissue damages has been used as a therapeutic intervention in traditional and complementary medicine to cure discomfort and illness. Eccentric exercise is known to cause significant necrosis and insulin resistance of skeletal muscle. The purpose of this study was to determine the magnitude of muscle damage and blood glucose responses during an oral glucose tolerance test (OGTT) after eccentric training in 21 young participants...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28406165/myostatin-mediates-abdominal-aortic-atherosclerosis-progression-by-inducing-vascular-smooth-muscle-cell-dysfunction-and-monocyte-recruitment
#9
D Verzola, S Milanesi, M Bertolotto, S Garibaldi, B Villaggio, C Brunelli, M Balbi, P Ameri, F Montecucco, D Palombo, G Ghigliotti, G Garibotto, J H Lindeman, C Barisione
Myostatin (Mstn) is a skeletal muscle growth inhibitor involved in metabolic disorders and heart fibrosis. In this study we sought to verify whether Mstn is also operative in atherosclerosis of abdominal aorta. In human specimens, Mstn expression was almost absent in normal vessels, became detectable in the media of non-progressive lesions and increased with the severity of the damage. In progressive atherosclerotic lesions, Mstn was present in the media, neointima, plaque shoulder and in infiltrating macrophages...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28397803/tomatidine-enhances-lifespan-and-healthspan-in-c-elegans-through-mitophagy-induction-via-the-skn-1-nrf2-pathway
#10
Evandro F Fang, Tyler B Waltz, Henok Kassahun, Qiping Lu, Jesse S Kerr, Marya Morevati, Elayne M Fivenson, Bradley N Wollman, Krisztina Marosi, Mark A Wilson, Wendy B Iser, D Mark Eckley, Yongqing Zhang, Elin Lehrmann, Ilya G Goldberg, Morten Scheibye-Knudsen, Mark P Mattson, Hilde Nilsen, Vilhelm A Bohr, Kevin G Becker
Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Small molecules capable of improving the health of older individuals are being explored. Small molecules that enhance cellular stress resistance are a promising avenue to alleviate declines seen in human aging. Tomatidine, a natural compound abundant in unripe tomatoes, inhibits age-related skeletal muscle atrophy in mice. Here we show that tomatidine extends lifespan and healthspan in C. elegans, an animal model of aging which shares many major longevity pathways with mammals...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28392896/injury-to-skeletal-muscle-of-mice-following-acute-and-sub-acute-pregabalin-exposure
#11
Mohammad Moshiri, Seyed Adel Moallem, Armin Attaranzadeh, Zahra Saberi, Leila Etemad
OBJECTIVES: Pregabalin (PGB) is a new antiepileptic drug that has received FDA approval for patient who suffers from central neuropathic pain, partial seizures, generalized anxiety disorder, fibromyalgia and sleep disorders. This study was undertaken to evaluate the possible adverse effects of PGB on the muscular system of mice. MATERIALS AND METHODS: To evaluate the effect of PGB on skeletal muscle, the animals were exposed to a single dose of 1, 2 or 5 g /kg or daily doses of 20, 40 or 80 mg/kg for 21 days, intraperitoneally (IP)...
March 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28391962/su9516-increases-%C3%AE-7%C3%AE-1-integrin-and-ameliorates-disease-progression-in-the-mdx-mouse-model-of-duchenne-muscular-dystrophy
#12
Apurva Sarathy, Ryan D Wuebbles, Tatiana M Fontelonga, Ashley R Tarchione, Lesley A Mathews Griner, Dante J Heredia, Andreia M Nunes, Suzann Duan, Paul D Brewer, Tyler Van Ry, Grant W Hennig, Thomas W Gould, Andrés E Dulcey, Amy Wang, Xin Xu, Catherine Z Chen, Xin Hu, Wei Zheng, Noel Southall, Marc Ferrer, Juan Marugan, Dean J Burkin
Duchenne muscular dystrophy (DMD) is a fatal muscle disease caused by mutations in the dystrophin gene, resulting in a complete loss of the dystrophin protein. Dystrophin is a critical component of the dystrophin glycoprotein complex (DGC), which links laminin in the extracellular matrix to the actin cytoskeleton within myofibers and provides resistance to shear stresses during muscle activity. Loss of dystrophin in DMD patients results in a fragile sarcolemma prone to contraction-induced muscle damage. The α7β1 integrin is a laminin receptor protein complex in skeletal and cardiac muscle and a major modifier of disease progression in DMD...
April 5, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28386340/lipoxin-a4-pretreatment-mitigates-skeletal-muscle-ischemia-reperfusion-injury-in-rats
#13
Haiyang Zong, Xinghui Li, Haodong Lin, Chunlin Hou, Fenfen Ma
The aim of this study was to investigate the protective effects and underlying anti-oxidative molecular mechanism of lipoxin A4 (LA4) in rats with ischemia/reperfusion (I/R)-injured skeletal muscle. A rat model of I/R-injured skeletal muscle was obtained by subjecting rats to a 3-h ligation of the right femoral artery followed by 3 h of reperfusion. Treatment with LA4 significantly ameliorated histological damage scores in I/R-injured skeletal muscle. LA4 treatment resulted in remarkable decreases in the wet weight/dry weight ratio (W/D ratio), inflammatory response, oxidative stress, and cell apoptosis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28371514/bi-layer-silk-fibroin-grafts-support-functional-esophageal-repair-in-a-rodent-model-of-caustic-injury
#14
Khalid Algarrahi, Debra Franck, Alyssa Savarino, Vivian Cristofaro, Xuehui Yang, Saif Affas, Frank-Mattias Schäfer, Maryrose P Sullivan, Carlos R Estrada, Joshua R Mauney
Surgical repair of caustic esophageal injuries with autologous gastrointestinal segments is often associated with dysmotility, dysphagia, and donor site morbidity and therefore alternative graft options are needed. Bi-layer silk fibroin (BLSF) scaffolds were assessed for their ability to support functional restoration of damaged esophageal tissues in a rat model of onlay esophagoplasty. Transient exposure of isolated esophageal segments with 40% NaOH led to corrosive esophagitis and a 91% reduction in the luminal cross-sectional area of damaged sites...
March 30, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28368329/vitamin-a-oral-supplementation-induces-oxidative-stress-and-suppresses-il-10-and-hsp70-in-skeletal-muscle-of-trained-rats
#15
Lyvia Lintzmaier Petiz, Carolina Saibro Girardi, Rafael Calixto Bortolin, Alice Kunzler, Juciano Gasparotto, Thallita Kelly Rabelo, Cristiane Matté, José Claudio Fonseca Moreira, Daniel Pens Gelain
Exercise training intensity is the major variant that influences the relationship between exercise, redox balance, and immune response. Supplement intake is a common practice for oxidative stress prevention; the effects of vitamin A (VA) on exercise training are not yet described, even though this molecule exhibits antioxidant properties. We investigated the role of VA supplementation on redox and immune responses of adult Wistar rats subjected to swimming training. Animals were divided into four groups: sedentary, sedentary + VA, exercise training, and exercise training + VA...
April 2, 2017: Nutrients
https://www.readbyqxmd.com/read/28367506/regulation-of-protein-and-mrna-expression-of-the-mtorc1-repressor-redd1-in-response-to-leucine-and-serum
#16
Adam J Black, Bradley S Gordon, Michael D Dennis, Leonard S Jefferson, Scot R Kimball
Expression of the mTORC1 repressor, Regulated in DNA Damage and Development 1 (REDD1), is elevated in skeletal muscle during various catabolic conditions including fasting, hindlimb immobilization, and sepsis. Conversely, REDD1 expression is suppressed by anabolic stimuli such as resistance exercise or nutrient consumption following a fast. Though it is known that nutrient consumption reduces REDD1 expression, it is largely unknown how nutrients and hormones individually contribute to the reduction in REDD1 expression...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28364603/ampelopsin-attenuates-the-atrophy-of-skeletal-muscle-from-d-gal-induced-aging-rats-through-activating-ampk-sirt1-pgc-1%C3%AE-signaling-cascade
#17
Xianjuan Kou, Jie Li, Xingran Liu, Xiaoqi Yang, Jingjing Fan, Ning Chen
The atrophy of skeletal muscle is highly correlated with oxidative damage, excessive apoptosis and dysfunctional autophagy. Ampelopsin, a natural flavonoid, has multiple biological functions including anti-inflammatory, anti-oxidative, and hepatoprotective functions. Sprague-Dawley (SD) rats subjected to intraperitoneal injection of d-galactose (d-gal) at the dose of 150mg/kg·d revealed an obvious atrophy of skeletal muscle with significantly reduced muscle mass/body mass ratio, cross-sectional area and fiber diameter of skeletal muscle in d-gal-induced aging rats when compared to normal control rats without d-gal administration for 6 consecutive weeks...
March 29, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28362420/isolation-of-intact-mitochondria-from-skeletal-muscle-by-differential-centrifugation-for-high-resolution-respirometry-measurements
#18
Siamak Djafarzadeh, Stephan Mathias Jakob
Mitochondria are involved in cellular energy metabolism and use oxygen to produce energy in the form of adenosine triphosphate (ATP). Differential centrifugation at low- and high-speed is commonly used to isolate mitochondria from tissues and cultured cells. Crude mitochondrial fractions obtained by differential centrifugation are used for respirometry measurements. The differential centrifugation technique is based on the separation of organelles according to their size and sedimentation velocity. The isolation of mitochondria is performed immediately after tissue harvesting...
March 8, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28346707/periurethral-muscle-derived-mononuclear-cell-injection-improves-urethral-sphincter-restoration-in-rats
#19
Marcelo Pitelli Turco, Alex Balduino de Souza, Isida de Campos Sousa, Paula Fratini, Mariana Matera Veras, Marcio Nogueira Rodrigues, José de Bessa, Marina Pandolphi Brolio, Katia Ramos Moreira Leite, Homero Bruschini, Miguel Srougi, Maria Angélica Miglino, Cristiano Mendes Gomes
AIMS: Investigate the effect of a novel cell-based therapy with skeletal muscle-derived mononuclear cells (SMDMCs) in a rat model of stress urinary incontinence. METHODS: Male Wistar-Kyoto rats' hind limb muscles were enzymatically dissociated, and SMDMCs were isolated without needing expansion. The cell population was characterized. Twenty female rats underwent urethrolysis. One week later, 10 rats received periurethral injection of 10(6) cells (SMDMC group), and 10 rats received saline injections (Saline group)...
March 27, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28338417/a-3d-tissue-printing-approach-for-validation-of-diffusion-tensor-imaging-in-skeletal-muscle
#20
David B Berry, Shangting You, John Warner, Lawrence R Frank, Shaochen Chen, Samuel R Ward
The ability to noninvasively assess skeletal muscle microstructure, which predicts function and disease, would be of significant clinical value. One method that holds this promise is diffusion tensor magnetic resonance imaging (DT-MRI), which is sensitive to the microscopic diffusion of water within tissues and has become ubiquitous in neuroimaging as a way of assessing neuronal structure and damage. However, its application to the assessment of changes in muscle microstructure associated with injury, pathology, or age remains poorly defined, because it is difficult to precisely control muscle microstructural features in vivo...
March 24, 2017: Tissue Engineering. Part A
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