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Skeletal muscle damage

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https://www.readbyqxmd.com/read/28104750/gene-networks-in-skeletal-muscle-following-endurance-exercise-are-co-expressed-in-blood-neutrophils-and-linked-with-blood-inflammation-markers
#1
James A Broadbent, Dayle Sampson, Surendran Sabapathy, Luke J Haseler, Karl-Heinz Wagner, Andrew Cameron Bulmer, Jonathan M Peake, Oliver Neubauer
It remains incompletely understood whether there is an association between the transcriptome profiles of skeletal muscle and blood leukocytes in response to exercise or other physiological stressors. We have previously analyzed the changes in the muscle and blood neutrophil transcriptome in eight trained men before and 3 h, 48 h and 96 h after 2 h cycling and running. Because we collected muscle and blood in the same individuals and under the same conditions, we were able to directly compare gene expression between the muscle and blood neutrophils...
January 19, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28091823/skeletal-muscle-inflammation-and-atrophy-in-heart-failure
#2
Kory J Lavine, Oscar L Sierra
Heart failure represents a systemic disease with profound effects on multiple peripheral tissues including skeletal muscle. Within the context of heart failure, perturbations in skeletal muscle physiology, structure, and function strongly contribute to exercise intolerance and the morbidity of this devastating disease. There is growing evidence that chronic heart failure imparts specific pathological changes within skeletal muscle beds resulting in muscle dysfunction and tissue atrophy. Mechanistically, systemic and local inflammatory responses drive critical aspects of this pathology...
January 14, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28089792/pharmacological-inhibition-of-pkc%C3%AE-counteracts-muscle-disease-in-a-mouse-model-of-duchenne-muscular-dystrophy
#3
V Marrocco, P Fiore, A Benedetti, S Pisu, E Rizzuto, A Musarò, L Madaro, B Lozanoska-Ochser, M Bouché
: Inflammation plays a considerable role in the progression of Duchenne Muscular Dystrophy (DMD), a severe muscle disease caused by a mutation in the dystrophin gene. We previously showed that genetic ablation of Protein Kinase C θ (PKCθ) in mdx, the mouse model of DMD, improves muscle healing and regeneration, preventing massive inflammation. To establish whether pharmacological targeting of PKCθ in DMD can be proposed as a therapeutic option, in this study we treated young mdx mice with the PKCθ inhibitor Compound 20 (C20)...
January 7, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28078069/skeletal-muscle-microalterations-in-patients-carrying-malignant-hyperthermia-related-mutations-of-the-e-c-coupling-machinery
#4
Manuela Lavorato, Pawan K Gupta, Philip M Hopkins, Clara Franzini-Armstrong
We have compared the ultrastructure of skeletal muscle biopsies from patients that have survived a [Malignant Hyperthermia, MH] episode and siblings that test positive for MH susceptibility with those from siblings that tested negatives. The aim is to establish whether life long exposure to the MH-related mutation effects may result in subtle abnormalities even in the absence of active episodes and/or clinically detectable deficiencies. Although a specific ultrastructural signature for MH mutants cannot be demonstrated, an MH related pattern of minor alterations does exist...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28078067/%C3%AE-linolenic-acid-reduces-tnf-induced-apoptosis-in-c2c12-myoblasts-by-regulating-expression-of-apoptotic-proteins
#5
Felicia Carotenuto, Dario Coletti, Paolo Di Nardo, Laura Teodori
Impaired regeneration and consequent muscle wasting is a major feature of muscle degenerative diseases. Nutritional interventions such as adjuvant strategy for preventing these conditions are recently gaining increasing attention. Ingestion of n3-polyunsaturated fatty acids has been suggested as having a positive impact on muscle diseases. We recently demonstrated that a diet enriched with plant derived n3-fatty acid, α-linolenic acid (ALA), exerts potent beneficial effects in preserving skeletal muscle regeneration in models of muscle dystrophy...
September 15, 2016: European Journal of Translational Myology
https://www.readbyqxmd.com/read/28076414/a-mri-compatible-combined-mechanical-loading-and-mr-elastography-setup-to-study-deformation-induced-skeletal-muscle-damage-in-rats
#6
Jules L Nelissen, Larry de Graaf, Willeke A Traa, Tom J L Schreurs, Kevin M Moerman, Aart J Nederveen, Ralph Sinkus, Cees W J Oomens, Klaas Nicolay, Gustav J Strijkers
Deformation of skeletal muscle in the proximity of bony structures may lead to deep tissue injury category of pressure ulcers. Changes in mechanical properties have been proposed as a risk factor in the development of deep tissue injury and may be useful as a diagnostic tool for early detection. MRE allows for the estimation of mechanical properties of soft tissue through analysis of shear wave data. The shear waves originate from vibrations induced by an external actuator placed on the tissue surface. In this study a combined Magnetic Resonance (MR) compatible indentation and MR Elastography (MRE) setup is presented to study mechanical properties associated with deep tissue injury in rats...
2017: PloS One
https://www.readbyqxmd.com/read/28068562/epigenetic-histopathological-and-transcriptomic-effects-following-exposure-to-depleted-uranium-in-adult-zebrafish-and-their-progeny
#7
Kewin Gombeau, Jean-Paul Bourdineaud, Jean-Luc Ravanat, Olivier Armant, Virginie Camilleri, Isabelle Cavalie, Magali Floriani, Christelle Adam-Guillermin
This study investigated the effects of adult zebrafish exposure to a nominal concentration of 20μgL(-1) of depleted uranium (DU) for six days upon DNA methylation, gene expression and the appearance of histopathological damage in their progeny. In the embryos at the 2-8 cell stage, the parental exposure induced significant DU accumulation, with levels seven times higher than those measured in the control embryos, but in larvae 96h post-fertilisation (hpf), uranium concentration had already returned to a level identical to that of the control larvae...
December 8, 2016: Aquatic Toxicology
https://www.readbyqxmd.com/read/28067975/assessment-of-acute-thermal-damage-volumes-in-muscle-using-magnetization-prepared-3d-t2-weighted-imaging-following-mri-guided-high-intensity-focused-ultrasound-therapy
#8
Robert M Staruch, Joris Nofiele, Jamie Walker, Chenchen Bing, Ananth J Madhuranthakam, April Bailey, Young-Sun Kim, Avneesh Chhabra, Dennis Burns, Rajiv Chopra
PURPOSE: To evaluate magnetization-prepared 3D T2 -weighted magnetic resonance imaging (MRI) measurements of acute tissue changes produced during ablative MR high-intensity focused ultrasound (MR-HIFU) exposures. MATERIALS AND METHODS: A clinical MR-HIFU system (3T) was used to generate thermal lesions (n = 24) in the skeletal muscles of three pigs. T1 -weighted, 2D T2 -weighted, and magnetization-prepared 3D T2 -weighted sequences were acquired before and after therapy to evaluate tissue changes following ablation...
January 9, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28060273/induction-and-assessment-of-exertional-skeletal-muscle-damage-in-humans
#9
Michael R Deyhle, Jacob R Sorensen, Robert D Hyldahl
Contraction-induced muscle damage via voluntary eccentric (lengthening) contractions offers an excellent model for studying muscle adaptation and recovery in humans. Herein we discuss the design of an eccentric exercise protocol to induce damage in the quadriceps muscles, marked by changes in strength, soreness, and plasma creatine kinase levels. This method is simple, ethical, and widely applicable since it is performed in human participants and eliminates the interspecies translation of the results. Subjects perform 300 maximal eccentric contractions of the knee extensor muscles at a speed of 120°/sec on an isokinetic dynamometer...
December 11, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28043891/adaptive-responses-of-heart-and-skeletal-muscle-to-spermine-oxidase-overexpression-evaluation-of-a-new-transgenic-mouse-model
#10
Roberta Ceci, Guglielmo Duranti, Alessia Leonetti, Stefano Pietropaoli, Federico Spinozzi, Lucia Marcocci, Roberto Amendola, Francesco Cecconi, Stefania Sabatini, Paolo Mariottini, Manuela Cervelli
Spermine oxidase oxidizes spermine to produce H2O2, spermidine, and 3-aminopropanal. It is involved in cell drug response, apoptosis, and in the etiology of several pathologies, including cancer. Spermine oxidase is an important positive regulator of muscle gene expression and fiber size and, when repressed, leads to muscle atrophy. We have generated a transgenic mouse line overexpressing Smox gene in all organs, named Total-Smox. The spermine oxidase overexpression was revealed by β-Gal staining and reverse-transcriptase/PCR analysis, in all tissues analysed...
December 30, 2016: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28042053/potential-role-for-the-vdr-agonist-elocalcitol-in-metabolic-control-evidences-in-human-skeletal-muscle-cells
#11
Cristina Antinozzi, Clarissa Corinaldesi, Carla Giordano, Annalinda Pisano, Bruna Cerbelli, Silvia Migliaccio, Luigi Di Luigi, Katia Stefanantoni, Gabriella Barbara Vannelli, Salvatore Minisola, Guido Valesini, Valeria Riccieri, Andrea Lenzi, Clara Crescioli
Vitamin D plays a pivotal role to maintain skeletal muscle integrity and health. Vitamin D deficiency characterizes inflammatory myopathy (IM) and diabetes, often overlapping diseases involving skeletal muscle damage. Vitamin D receptor (VDR) agonists likely exert beneficial effects in both IM and metabolic disturbances. We aim to evaluate in vitro the effect of elocalcitol, a non-hypercalcemic VDR agonist, on the biomolecular metabolic machinery of human skeletal muscle cells (Hfsmc), vs. insulin (I). We analyzed GLUT4, Flotillin-1, Caveolin-3 and Caveolin-1 cell expression/localization; mTOR, AKT, ERK and 4E-BP1 phosphorylation; IL-6 myokine release; VDR expression...
December 29, 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28040084/do-skeletal-muscle-mscs-in-humans-contribute-to-bone-repair-a-systematic-review
#12
Heather Owston, Peter V Giannoudis, Elena Jones
Mesenchymal stem cells (MSC) from bone marrow and periosteum are known to be heavily involved in fracture repair and bone regeneration is thought to be impaired when the surrounding skeletal muscle is damaged. Recent literature from mouse in vivo models suggest that cells originating from skeletal muscle can occupy a fracture callus during open fracture repair when periosteum is compromised. This systematic review set out to ascertain whether there are MSCs residing in human skeletal muscle and whether cells from human skeletal muscle are capable of forming bone in vitro and in vivo...
December 2016: Injury
https://www.readbyqxmd.com/read/28039193/short-term-intense-exercise-training-reduces-stress-markers-and-alters-the-transcriptional-response-to-exercise-in-skeletal-muscle
#13
James Matthew Hinkley, Adam R Konopka, Miranda K Suer, Matthew P Harber
The purpose of this investigation was to examine the influence of short-term intense endurance training on cycling performance, along with the acute and chronic signaling responses of skeletal muscle stress and stability markers. Ten recreationally active subjects (25 ± 2 yr, 79 ± 3 kg, 47 ± 2 ml·kg·min-1) were studied before and after a 12-day cycling protocol to examine the effects of short-term intense (70-100% VO2max) exercise training on resting and exercise-induced regulation of molecular factors related to skeletal muscle cellular stress and protein stability...
December 30, 2016: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28035727/the-role-of-tgf-%C3%AE-1-during-skeletal-muscle-regeneration
#14
REVIEW
Kamila Delaney, Paulina Kasprzycka, Maria A Ciemerych, Malgorzata Zimowska
The injury of adult skeletal muscle initiates series of well-coordinated events that lead to the efficient repair of the damaged tissue. Any disturbances during muscle myolysis or reconstruction may result in the unsuccessful regeneration, characterized by strong inflammatory response and formation of connective tissue, i.e. fibrosis. The switch between proper regeneration of skeletal muscle and development of fibrosis is controlled by various factors. Among them are those belonging to the transforming growth factor β family...
December 29, 2016: Cell Biology International
https://www.readbyqxmd.com/read/28031099/low-dose-simvastatin-increases-skeletal-muscle-sensitivity-to-caffeine-and-halothane
#15
Xu-Lei Cui, Ying-Lin Wang, Gang Tan, Ai-Lun Luo, Xiang-Yang Guo
Objective To determine whether the myotoxic side effects of statin simvastatin affect skeletal muscle's sensitivity to caffeine and halothane.Methods Primary cultured neonate rat skeletal myotubes were treated with 0.01-5.0 μmol/L simvastatin for 48 hours. MTT was used to evaluate cellular viability. The gross morphology and microstructure of the myotubes were observed with a light and electron microscope, respectively. The intracellular calcium concentrations ([Ca(2+)]i) at rest and in response to caffeine and halothane were investigated by fluorescence calcium imaging...
June 20, 2016: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
https://www.readbyqxmd.com/read/28027662/redox-control-of-skeletal-muscle-regeneration
#16
Emmeran Le Moal, Vincent Pialoux, Gaëtan Juban, Carole Groussard, Hassan Zouhal, Bénédicte Chazaud, Rémi Mounier
Skeletal muscle shows high plasticity in response to external demand. Moreover, adult skeletal muscle is capable of complete regeneration after injury, due to the properties of Muscle Stem Cells (MuSCs), the satellite cells, which follow a tightly regulated myogenic program to generate both new myofibers and new MuSCs for further needs. Whereas reactive oxygen species (ROS) and reactive nitrogen species (RNS) have long been associated with skeletal muscle physiology, their implication in the cell and molecular processes at work during muscle regeneration is more recent...
December 27, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28027190/purified-human-skeletal-muscle-derived-stem-cells-enhance-the-repair-and-regeneration-in-the-damaged-urethra
#17
Nobuyuki Nakajima, Tetsuro Tamaki, Maki Hirata, Shuichi Soeda, Masahiro Nitta, Akio Hoshi, Toshiro Terachi
BACKGROUND: Postoperative damage of the urethral rhabdosphincter and nerve-vascular networks is a major complication of radical prostatectomy and generally causes incontinence and/or erectile dysfunction. The human skeletal muscle-derived stem cells, which have a synchronized reconstitution capacity of muscle-nerve-blood vessel units, were applied to this damage. METHODS: Cells were enzymatically extracted from the human skeletal muscle, sorted using flow cytometry as CD34/45 (Sk-34) and CD29/34/45 (Sk-DN/29) fractions, and separately cultured/expanded in appropriate conditions within 2 weeks...
December 23, 2016: Transplantation
https://www.readbyqxmd.com/read/28024587/novel-approach-towards-aligned-pcl-collagen-nanofibrous-constructs-from-a-benign-solvent-system
#18
Dirk Dippold, Aijia Cai, Moritz Hardt, Aldo R Boccaccini, Raymund Horch, Justus P Beier, Dirk W Schubert
Under several conditions such as severe trauma skeletal muscle lack the ability to reorganize and the loss of muscle function is inevitable. The application of tissue engineered constructs is a promising approach in regenerative therapies for damaged muscular tissue. Therefore, the development of highly aligned scaffolds based on polycaprolactone (PCL) has been studied extensively. Nanofiber scaffolds containing collagen have mostly been fabricated via electrospinning using highly corrosive 1,1,1,3,3,3 hexafluoro-2-propanol (HFIP) so far...
March 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28012598/mechanisms-underpinning-protection-against-eccentric-exercise-induced-muscle-damage-by-ischemic-preconditioning
#19
Alexander Franz, Michael Behringer, Kazunori Nosaka, Bettina Alexandra Buhren, Holger Schrumpf, Constantin Mayer, Christoph Zilkens, Moritz Schumann
Eccentric exercise training is effective for increasing muscle mass and strength, and improving insulin sensitivity and blood lipid profiles. However, potential muscle damage symptoms such as prolonged loss of muscle function and delayed onset of muscle soreness may restrict the use of eccentric exercise, especially in clinical populations. Therefore, strategies to reduce eccentric exercise-induced muscle damage (EIMD) are necessary, and an extensive number of scientific studies have tried to identify potential intervention modalities to perform eccentric exercises without adverse effects...
January 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/27999547/myocardial-contractile-dysfunction-is-present-without-histopathology-in-a-mouse-model-of-limb-girdle-muscular-dystrophy-2f-and-is-prevented-after-claudin-5-virotherapy
#20
Nima Milani-Nejad, Eric J Schultz, Jessica L Slabaugh, Paul M L Janssen, Jill A Rafael-Fortney
Mutations in several members of the dystrophin glycoprotein complex lead to skeletal and cardiomyopathies. Cardiac care for these muscular dystrophies consists of management of symptoms with standard heart medications after detection of reduced whole heart function. Recent evidence from both Duchenne muscular dystrophy patients and animal models suggests that myocardial dysfunction is present before myocardial damage or deficiencies in whole heart function, and that treatment prior to heart failure symptoms may be beneficial...
2016: Frontiers in Physiology
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