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Bacteroides fragilis

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https://www.readbyqxmd.com/read/29660284/non-microbicidal-small-molecule-inhibition-of-polysaccharide-metabolism-in-human-gut-microbes-a-potential-therapeutic-avenue
#1
Anthony D Santilli, Elizabeth M Dawson, Kristi Whitehead, Daniel C Whitehead
A new approach for the non-microbicidal phenotypic manipulation of prominent gastrointestinal microbes is presented. Low micromolar concentrations of a chemical probe, acarbose, can selectively inhibit the Starch Utilization System and ablate the ability of Bacteroides thetaiotaomicron and B. fragilis strains to metabolize potato starch and pullulan. This strategy has potential therapeutic relevance for the selective modulation of the GI microbiota in a non-microbicidal manner.
April 16, 2018: ACS Chemical Biology
https://www.readbyqxmd.com/read/29651861/the-first-characterized-carbapenem-resistant-bacteroides-fragilis-strain-from-croatia-and-the-case-study-for-it
#2
Maja Bogdan, Ljilijana Perić, Katalin Ördög, Dubravka Vuković, Edit Urbán, József Sóki
An imipenem-resistant Bacteroides fragilis strain was isolated from the blood of a 72-year-old male patient with a urinary bladder tumor in Osijek, Croatia. This strain was also resistant to ampicillin, piperacillin/tazobactam, cefoxitin, clindamycin, tetracycline, and harbored cfiA, ermF, and tetQ genes where the high-level expression of the cfiA carbapenem-resistant gene was driven by an IS1187 element. Interestingly, despite the carbapenem-resistant feature of the B. fragilis from blood, the patient relatively easily recovered from the bacteremia...
April 13, 2018: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/29642940/multi-cohort-analysis-of-colorectal-cancer-metagenome-identified-altered-bacteria-across-populations-and-universal-bacterial-markers
#3
Zhenwei Dai, Olabisi Oluwabukola Coker, Geicho Nakatsu, William K K Wu, Liuyang Zhao, Zigui Chen, Francis K L Chan, Karsten Kristiansen, Joseph J Y Sung, Sunny Hei Wong, Jun Yu
BACKGROUND: Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes as markers for early diagnosis has also been reported. However, cohort specific noises may distort the structure of microbial dysbiosis in CRC and lead to inconsistent results among studies. In this regard, our study targeted at exploring changes in gut microbiota that are universal across populations at species level...
April 11, 2018: Microbiome
https://www.readbyqxmd.com/read/29642831/-identification-of-anaerobic-gram-negative-bacilli-isolated-from-various-clinical-specimens-and-determination-of-antibiotic-resistance-profiles-with-e-test-methods
#4
Cengiz Demir, Recep Keşli
The aim of this study was to identify gram-negative anaerobic bacilli isolated from various clinical specimens that were obtained from patients with suspected anaerobic infections and to determine the antibiotic resistance profiles by using the antibiotic concentration gradient method. The study was performed in Afyon Kocatepe University Ahmet Necdet Sezer Research and Practice Hospital, Medical Microbiology Laboratory between 1 November 2014 and 30 October 2015. Two hundred and seventyeight clinical specimens accepted for anaerobic culture were enrolled in the study...
January 2018: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/29626622/bacteroides-fragilis-a-whole-maldi-based-workflow-from-identification-to-confirmation-of-carbapenemase-production-for-routine-laboratories
#5
M Cordovana, M Kostrzewa, J Sóki, E Witt, S Ambretti, A B Pranada
Bacteroides fragilis is a frequent anaerobic pathogen and can cause severe infections. Resistance to carbapenems, associated with the cfiA gene encoded carbapenemase, represents an emerging problem. To date, no rapid methods are available to detect and confirm this resistance mechanism in routine laboratories, and the missed recognition of carbapenemase-producing strains can lead to therapeutic failures. In this study we have investigated a whole MALDI-TOF MS-based workflow to detect carbapenemase-producing B...
April 4, 2018: Anaerobe
https://www.readbyqxmd.com/read/29625653/the-role-of-efflux-pumps-in-bacteroides-fragilis-resistance-to-antibiotics
#6
REVIEW
Reza Ghotaslou, Mina Yekani, Mohammad Yousef Memar
The resistance of Bacteroides fragilis to the most antimicrobial agents has been reported in the world. Identification of the microbial resistance mechanisms can play an important role in controlling these resistances. Currently, B. fragilis is resistant to most antibiotics. The multi-drug efflux pumps have been shown to underlie the antimicrobial resistance in B. fragilis strains. Two types of these efflux pumps including RND and MATE can be regarded as main structures responsible for antibiotic resistance...
May 2018: Microbiological Research
https://www.readbyqxmd.com/read/29615954/microbiome-mediated-upregulation-of-microrna-146a-in-sporadic-alzheimer-s-disease
#7
Yuhai Zhao, Walter J Lukiw
The first indication of a potential mechanistic link between the pathobiology of the human gastrointestinal (GI)-tract microbiome and its contribution to the pathogenetic mechanisms of sporadic Alzheimer's disease (AD) came a scant 4 years ago (1). Ongoing research continues to strengthen the hypothesis that neurotoxic microbial-derived components of the GI tract microbiome can cross aging GI tract and blood-brain barriers and contribute to progressive proinflammatory neurodegeneration, as exemplified by the AD-process...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29608253/the-direct-and-indirect-association-of-cervical-microbiota-with-the-risk-of-cervical-intraepithelial-neoplasia
#8
Chaoting Zhang, Ying Liu, Weijiao Gao, Yaqi Pan, Yunong Gao, Jing Shen, Hongchao Xiong
Cervical microbiota composition is associated with cervical HPV infection and CIN severity. Previous studies only assessed the total association between cervical microbiota and HPV infections or CINs, and yet no study reported the direct and indirect associations between cervical microbiota and CINs mediated by HPV infection, respectively. The aim of this study was to investigate the direct and indirect associations between microbiotas and CIN severity. Cervical microbiota of 126 women with CIN 1- (normal cytology and CIN 1) and 40 with CIN 2+ (CIN 2 and CIN 3) were analyzed using Illumina sequencing based on the 16S rRNA gene...
April 2, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29573336/the-impact-of-klebsiella-pneumoniae-in-lower-gastrointestinal-tract-diseases
#9
REVIEW
Christina Parvinder Kaur, Jamuna Vadivelu, Samudi Chandramathi
The 2016 Global Burden of Disease report by WHO revealed that diseases of the gastrointestinal tract had one of the highest incidence rates worldwide. The plethora of factors that contribute to the development of gastrointestinal tract (GIT) related illnesses can be divided into genetic, environmental and lifestyle factors. Apart from that, the role that infectious agents play in the development of GIT diseases has piqued the interest of researchers worldwide. The human gut harbours approximately 101 to 1012 cfu/ml bacteria in it with increasing concentration towards the lower GIT...
March 24, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29555391/antimicrobial-susceptibility-of-common-pathogens-isolated-from-postoperative-intra-abdominal-infections-in-japan
#10
Yoshio Takesue, Shinya Kusachi, Hiroshige Mikamo, Junko Sato, Akira Watanabe, Hiroshi Kiyota, Satoshi Iwata, Mitsuo Kaku, Hideaki Hanaki, Yoshinobu Sumiyama, Yuko Kitagawa, Kazuhiko Nakajima, Takashi Ueda, Motoi Uchino, Toru Mizuguchi, Yoshiyasu Ambo, Masafumi Konosu, Keiichiro Ishibashi, Akihisa Matsuda, Kazuo Hase, Yasushi Harihara, Koji Okabayashi, Shiko Seki, Takuo Hara, Koshi Matsui, Yoichi Matsuo, Minako Kobayashi, Shoji Kubo, Kazuhisa Uchiyama, Junzo Shimizu, Ryohei Kawabata, Hiroki Ohge, Shinji Akagi, Masaaki Oka, Toshiro Wakatsuki, Katsunori Suzuki, Kohji Okamoto, Katsunori Yanagihara
The principle of empirical therapy for patients with intra-abdominal infections (IAI) should include antibiotics with activity against Enterobacteriaceae and Bacteroides fragilis group species. Coverage of Pseudomonas aeruginosa, Enterobacter cloacae, and Enterococcus faecalis is also recommended for hospital-associated IAI. A nationwide survey was conducted to investigate the antimicrobial susceptibility of pathogens isolated from postoperative IAI. All 504 isolates were collected at 26 institutions and referred to a central laboratory for susceptibility testing...
March 16, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29544099/bacteroides-fragilis-toxin-coordinates-a-pro-carcinogenic-inflammatory-cascade-via-targeting-of-colonic-epithelial-cells
#11
Liam Chung, Erik Thiele Orberg, Abby L Geis, June L Chan, Kai Fu, Christina E DeStefano Shields, Christine M Dejea, Payam Fathi, Jie Chen, Benjamin B Finard, Ada J Tam, Florencia McAllister, Hongni Fan, Xinqun Wu, Sudipto Ganguly, Andriana Lebid, Paul Metz, Sara W Van Meerbeke, David L Huso, Elizabeth C Wick, Drew M Pardoll, Fengyi Wan, Shaoguang Wu, Cynthia L Sears, Franck Housseau
No abstract text is available yet for this article.
March 14, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29528123/finding-a-needle-in-a-haystack-bacteroides-fragilis-polysaccharide-a-as-the-archetypical-symbiosis-factor
#12
REVIEW
Deniz Erturk-Hasdemir, Dennis L Kasper
Starting from birth, all animals develop a symbiotic relationship with their resident microorganisms that benefits both the microbe and the host. Recent advances in technology have substantially improved our ability to direct research toward the identification of important microbial species that affect host physiology. The identification of specific commensal molecules from these microbes and their mechanisms of action is still in its early stages. Polysaccharide A (PSA) of Bacteroides fragilis is the archetypical example of a commensal molecule that can modulate the host immune system in health and disease...
March 12, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29501419/antimicrobial-susceptibility-testing-of-bacteroides-fragilis-using-the-maldi-biotyper-antibiotic-susceptibility-test-rapid-assay-mbt-astra
#13
Ulrik Stenz Justesen, Ziyap Acar, Thomas Vognbjerg Sydenham, Åsa Johansson
This study evaluated the MBT-ASTRA for antimicrobial susceptibility testing of Bacteroides fragilis with different classes of antibiotics. MALDI-TOF MS peak AUCs from suspensions with B. fragilis with and without an antibiotic were used to calculate the relative growth (AUC "with antibiotic" divided by "without antibiotic"). Antimicrobial susceptibility testing of B. fragilis ATCC 25285 (susceptible) and B. fragilis O18 (resistant) was demonstrated with a clear difference of the relative growth between susceptible and resistant...
March 2, 2018: Anaerobe
https://www.readbyqxmd.com/read/29454108/detection-of-b-fragilis-group-and-diversity-of-bft-enterotoxin-and-antibiotic-resistance-markers-cepa-cfia-and-nim-among-intestinal-bacteroides-fragilis-strains-in-patients-with-inflammatory-bowel-disease
#14
Marjan Rashidan, Masoumeh Azimirad, Masoud Alebouyeh, Mehdi Ghobakhlou, Hamid Asadzadeh Aghdaei, Mohammad Reza Zali
We compared frequency of the members of B. fragilis group in 100 and 20 colon biopsy specimens of inflammatory bowel disease (IBD) and non-IBD patients. Agar dilution and PCR were orderly used to detect minimal inhibitory concentration of ampicillin, imipenem, and metronidazole, and carriage of related resistance genes cepA, cfi, and nim. B. fragilis group was detected in 38% of IBD (UC: 36/89; CD:1/11) and 25% (5/20) of non-IBD patients. While B. vulgatus (UC: 20/36, CD: 1/2, control: 1/6); B. fragilis (UC: 18/36, CD: 1/2, control: 5/6); B...
February 14, 2018: Anaerobe
https://www.readbyqxmd.com/read/29432848/characterization-of-a-recombinant-bacteroides-fragilis-sialidase-expressed-in-escherichia-coli
#15
Takaaki Yamamoto, Hideyo Ugai, Haruyuki Nakayama-Imaohji, Ayano Tada, Miad Elahi, Hitoshi Houchi, Tomomi Kuwahara
The human gut commensal Bacteroides fragilis produces sialidases that remove a terminal sialic acid from host-derived polysaccharides. Sialidase is considered to be involved in B. fragilis infection pathology. A native B. fragilis sialidase has been purified and characterized, and was shown to be post-translationally modified by glycosylation. However, the biochemical properties of recombinant B. fragilis sialidase expressed in a heterologous host remain uncharacterized. In this study, we examined the enzymatic properties of the 60-kDa sialidase NanH1 of B...
February 9, 2018: Anaerobe
https://www.readbyqxmd.com/read/29420293/patients-with-familial-adenomatous-polyposis-harbor-colonic-biofilms-containing-tumorigenic-bacteria
#16
Christine M Dejea, Payam Fathi, John M Craig, Annemarie Boleij, Rahwa Taddese, Abby L Geis, Xinqun Wu, Christina E DeStefano Shields, Elizabeth M Hechenbleikner, David L Huso, Robert A Anders, Francis M Giardiello, Elizabeth C Wick, Hao Wang, Shaoguang Wu, Drew M Pardoll, Franck Housseau, Cynthia L Sears
Individuals with sporadic colorectal cancer (CRC) frequently harbor abnormalities in the composition of the gut microbiome; however, the microbiota associated with precancerous lesions in hereditary CRC remains largely unknown. We studied colonic mucosa of patients with familial adenomatous polyposis (FAP), who develop benign precursor lesions (polyps) early in life. We identified patchy bacterial biofilms composed predominately of Escherichia coli and Bacteroides fragilis Genes for colibactin ( clbB ) and Bacteroides fragilis toxin ( bft ), encoding secreted oncotoxins, were highly enriched in FAP patients' colonic mucosa compared to healthy individuals...
February 2, 2018: Science
https://www.readbyqxmd.com/read/29420132/tumour-associated-and-non-tumour-associated-microbiota-addendum
#17
Burkhardt Flemer, Maeve Herlihy, Micheal O'Riordain, Fergus Shanahan, Paul W O'Toole
In a recent study1 we reported that tissue-associated microbial Co-abundance Groups (CAGs) were differentially associated with CRC. Two of the CAGs, which we named Pathogen CAG and Prevotella CAG, were correlated with a gene expression signature indicative of a TH17 response. A TH17 response has been associated with decreased survival in patients with CRC2, and members of the Pathogen CAG such as Fusobacterium nucleatum, Escherichia coli and Bacteroides fragilis have been repeatedly reported to be associated with CRC-development...
February 8, 2018: Gut Microbes
https://www.readbyqxmd.com/read/29412357/identification-of-the-alpha-enolase-p46-in-the-extracellular-membrane-vesicles-of-bacteroides-fragilis
#18
Thais Gonçalves Ferreira, Camilla Nunes Dos Reis Trindade, Petra Bell, André Teixeira-Ferreira, Jonas E Perales, Rossiane C Vommaro, Regina Maria Cavalcanti Pilotto Domingues, Eliane de Oliveira Ferreira
BACKGROUND: Members of the Bacteroides fragilis group are the most important components of the normal human gut microbiome, but are also major opportunistic pathogens that are responsible for significant mortality, especially in the case of bacteraemia and other severe infections, such as intra-abdominal abscesses. Up to now, several virulence factors have been described that might explain the involvement of B. fragilis in these infections. The secretion of extracellular membrane vesicles (EMVs) has been proposed to play a role in pathogenesis and symbiosis in gram-negative bacteria, by releasing soluble proteins and other molecules...
March 2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29398651/bacteroides-fragilis-toxin-coordinates-a-pro-carcinogenic-inflammatory-cascade-via-targeting-of-colonic-epithelial-cells
#19
Liam Chung, Erik Thiele Orberg, Abby L Geis, June L Chan, Kai Fu, Christina E DeStefano Shields, Christine M Dejea, Payam Fathi, Jie Chen, Benjamin B Finard, Ada J Tam, Florencia McAllister, Hongni Fan, Xinqun Wu, Sudipto Ganguly, Andriana Lebid, Paul Metz, Sara W Van Meerbeke, David L Huso, Elizabeth C Wick, Drew M Pardoll, Fengyi Wan, Shaoguang Wu, Cynthia L Sears, Franck Housseau
Pro-carcinogenic bacteria have the potential to initiate and/or promote colon cancer, in part via immune mechanisms that are incompletely understood. Using ApcMin mice colonized with the human pathobiont enterotoxigenic Bacteroides fragilis (ETBF) as a model of microbe-induced colon tumorigenesis, we show that the Bacteroides fragilis toxin (BFT) triggers a pro-carcinogenic, multi-step inflammatory cascade requiring IL-17R, NF-κB, and Stat3 signaling in colonic epithelial cells (CECs). Although necessary, Stat3 activation in CECs is not sufficient to trigger ETBF colon tumorigenesis...
February 14, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29396061/anaerobic-bacterial-meningitis-in-adults
#20
Jun-Jun Lee, Chia-Yi Lien, Chun-Chih Chien, Chi-Ren Huang, Nai-Wen Tsai, Chiung-Chih Chang, Cheng-Hsien Lu, Wen-Neng Chang
Anaerobic infection is a very uncommon condition in adult bacterial meningitis (ABM), and its clinical characteristics have yet to be clarified. We enrolled 540 patients with culture-proven bacterial meningitis during a study period of 30 years (1986-2015), of whom 13 (2.4%) had anaerobic infections. These 13 patients were eight men and five women, aged 22-77 years. Among them, 53.8% (7/13) had a postneurosurgical state as the preceding event, and 79.6% (10/13) had underlying medical conditions including diabetes mellitus, malignancy, liver cirrhosis, cerebral infarct and alcoholism...
April 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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