keyword
https://read.qxmd.com/read/38516962/an-international-review-of-the-characteristics-of-viral-nucleic-acid-amplification-testing-nat-reveals-a-trend-towards-the-use-of-smaller-pool-sizes-and-individual-donation-nat
#1
JOURNAL ARTICLE
Helen M Faddy, Carla Osiowy, Brian Custer, Michael Busch, Susan L Stramer, Melinda M Dean, Jessika Acutt, Elvina Viennet, Thijs van de Laar, Wai-Chiu Tsoi, Claire Styles, Phil Kiely, Angelo Margaritis, So-Yong Kwon, Yan Qiu, Xuelian Deng, Antoine Lewin, Signe Winther Jørgensen, Christian Erikstrup, David Juhl, Silvia Sauleda, Bernardo Armando Camacho Rodriguez, Lisbeth Jennifer Catherine Soto Coral, Paula Andrea Gaviria García, Sineenart Oota, Sheila F O'Brien, Silvano Wendel, Emma Castro, Laura Navarro Pérez, Heli Harvala, Katy Davison, Claire Reynolds, Lisa Jarvis, Piotr Grabarczyk, Aneta Kopacz, Magdalena Łętowska, Niamh O'Flaherty, Fiona Young, Padraig Williams, Lisa Burke, Sze Sze Chua, An Muylaert, Isabel Page, Ann Jones, Christoph Niederhauser, Marion Vermeulen, Syria Laperche, Pierre Gallian, Masahiro Satake, Marcelo Addas-Carvalho, Sebastián Blanco, Sandra V Gallego, Axel Seltsam, Marijke Weber-Schehl, Arwa Z Al-Riyami, Khuloud Al Maamari, Fatma Ba Alawi, Hem Chandra Pandey, Rochele Azevedo França, Richard Charlewood
BACKGROUND AND OBJECTIVES: Nucleic acid-amplification testing (NAT) is used for screening blood donations/donors for blood-borne viruses. We reviewed global viral NAT characteristics and NAT-yield confirmatory testing used by blood operators. MATERIALS AND METHODS: NAT characteristics and NAT-yield confirmatory testing used during 2019 was surveyed internationally by the International Society of Blood Transfusion Working Party Transfusion-Transmitted Infectious Diseases...
March 22, 2024: Vox Sanguinis
https://read.qxmd.com/read/38510319/operative-treatment-of-ulnar-collateral-ligament-injury-in-female-athletes
#2
JOURNAL ARTICLE
Nicholas O Gerard, Sean C Clark, Michael J O'Brien, Mary K Mulcahey, Felix H Savoie
BACKGROUND: Ulnar collateral ligament (UCL) reconstruction has been the standard surgical intervention for elite male athletes with UCL insufficiency. Recently, UCL repair and augmentation with an internal brace has been increasingly performed. PURPOSE: To evaluate the clinical and functional outcomes as well as return-to-sport rate after UCL repair in female athletes. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Included were 15 female athletes (mean age, 16...
March 2024: Orthopaedic Journal of Sports Medicine
https://read.qxmd.com/read/38509364/adaptive-foraging-behaviours-in-the-horn-of-africa-during-toba-supereruption
#3
JOURNAL ARTICLE
John Kappelman, Lawrence C Todd, Christopher A Davis, Thure E Cerling, Mulugeta Feseha, Abebe Getahun, Racheal Johnsen, Marvin Kay, Gary A Kocurek, Brett A Nachman, Agazi Negash, Tewabe Negash, Kaedan O'Brien, Michael Pante, Minghua Ren, Eugene I Smith, Neil J Tabor, Dereje Tewabe, Hong Wang, Deming Yang, Solomon Yirga, Jordan W Crowell, Matthew F Fanuka, Teshager Habtie, Jayde N Hirniak, Carla Klehm, Natalia D Loewen, Sahleselasie Melaku, Sierra M Melton, Timothy S Myers, Sarah Millonig, Megan C Plummer, Keenan J Riordan, Nicholas A Rosenau, Anne Skinner, Abraham K Thompson, Lindsey M Trombetta, Adrienne Witzel, Ephrem Assefa, Maria Bodansky, Ayenachew A Desta, Christopher J Campisano, Daniel Dalmas, Connor Elliott, Metasebia Endalamaw, Nicholas J Ford, Frederick Foster, Tomas Getachew, Yibai Li Haney, Brittney H Ingram, Jonayah Jackson, Curtis W Marean, Sissi Mattox, Karla de la Cruz Medina, Gebretsadkan Mulubrhan, Keri Porter, Alexis Roberts, Perla Santillan, Alaric Sollenberger, Julia Sponholtz, Jessica Valdes, Lani Wyman, Meklit Yadeta, Sierra Yanny
Although modern humans left Africa multiple times over 100,000 years ago, those broadly ancestral to non-Africans dispersed less than 100,000 years ago1 . Most models hold that these events occurred through green corridors created during humid periods because arid intervals constrained population movements2 . Here we report an archaeological site-Shinfa-Metema 1, in the lowlands of northwest Ethiopia, with Youngest Toba Tuff cryptotephra dated to around 74,000 years ago-that provides early and rare evidence of intensive riverine-based foraging aided by the likely adoption of the bow and arrow...
March 20, 2024: Nature
https://read.qxmd.com/read/38503661/vaccine-value-profile-for-klebsiella-pneumoniae
#4
JOURNAL ARTICLE
Ziyaad Dangor, Nicole Benson, James A Berkley, Julia Bielicki, Merijn W Bijsma, Jonathan Broad, Ed T Buurman, Alan Cross, Erin M Duffy, Kathryn E Holt, Pui-Ying Iroh Tam, Mark Jit, Konstantinos Karampatsas, Michael Katwere, Gaurav Kwatra, Ramanan Laxminarayan, Kirsty Le Doare, Robert Mboizi, Francesca Micoli, Catrin E Moore, Eve Nakabembe, Nichola R Naylor, Seamus O'Brien, Courtney Olwagen, Denasha Reddy, Charlene Rodrigues, David A Rosen, Manish Sadarangani, Padmini Srikantiah, Sharon M Tennant, Mateusz Hasso-Agopsowicz, Shabir A Madhi
Klebsiella pneumoniae causes community- and healthcare-associated infections in children and adults. Globally in 2019, an estimated 1.27 million (95% Uncertainty Interval [UI]: 0.91-1.71) and 4.95 million (95% UI: 3.62-6.57) deaths were attributed to and associated with bacterial antimicrobial resistance (AMR), respectively. K. pneumoniae was the second leading pathogen in deaths attributed to AMR resistant bacteria. Furthermore, the rise of antimicrobial resistance in both community- and hospital-acquired infections is a concern for neonates and infants who are at high risk for invasive bacterial disease...
March 18, 2024: Vaccine
https://read.qxmd.com/read/38491957/somatic-variants-as-a-cause-of-drug-resistant-epilepsy-including-mesial-temporal-lobe-epilepsy-with-hippocampal-sclerosis
#5
JOURNAL ARTICLE
Robert J Carton, Michael G Doyle, Hugh Kearney, Charles A Steward, Nicholas J Lench, Anthony Rogers, Erin L Heinzen, Seamus McDonald, Joanna Fay, Austin Lacey, Alan Beausang, Jane Cryan, Francesca Brett, Hany El-Naggar, Peter Widdess-Walsh, Daniel Costello, Ronan Kilbride, Colin P Doherty, Kieron J Sweeney, Donncha F O'Brien, David C Henshall, Norman Delanty, Gianpiero L Cavalleri, Katherine A Benson
OBJECTIVE: The contribution of somatic variants to epilepsy has recently been demonstrated, particularly in the etiology of malformations of cortical development. The aim of this study was to determine the diagnostic yield of somatic variants in genes that have been previously associated with a somatic or germline epilepsy model, ascertained from resected brain tissue from patients with multidrug-resistant focal epilepsy. METHODS: Forty-two patients were recruited across three categories: (1) malformations of cortical development, (2) mesial temporal lobe epilepsy with hippocampal sclerosis, and (3) nonlesional focal epilepsy...
March 16, 2024: Epilepsia
https://read.qxmd.com/read/38487212/cardiometabolic-improvements-after-metabolic-surgery-and-related-presurgery-factors
#6
JOURNAL ARTICLE
Lei Wang, Michael T O'Brien, Xinmeng Zhang, You Chen, Wayne J English, Brandon Williams, Matthew Spann, Vance Albaugh, Xiao-Ou Shu, Charles R Flynn, Danxia Yu
CONTEXT: Metabolic surgery remains the most effective and durable treatment for severe obesity and related metabolic diseases. OBJECTIVE: We examined cardiometabolic improvements after metabolic surgery and associated presurgery demographic and clinical factors in a large multiracial cohort. METHODS: Included were 7804 patients (20-79 years) undergoing first-time metabolic surgery at Vanderbilt University Medical Center from 1999 to 2022. Pre- and 1-year postsurgery cardiometabolic profiles were extracted from medical records, including body mass index (BMI), blood pressure, blood lipids, glucose, and hemoglobin A1c...
March 12, 2024: Journal of the Endocrine Society
https://read.qxmd.com/read/38473407/combined-antitumor-effect-of-the-serine-protease-urokinase-inhibitor-upamostat-and-the-sphingosine-kinase-2-inhibitor-opaganib-on-cholangiocarcinoma-patient-derived-xenografts
#7
JOURNAL ARTICLE
Faizal Z Asumda, Nellie A Campbell, Mohamed A Hassan, Reza Fathi, Daniella F Vasquez Rico, Melanie Kiem, Ethan V Vang, Yo Han Kim, Xin Luo, Daniel R O'Brien, Sarah A Buhrow, Joel M Reid, Michael J Moore, Vered Katz Ben-Yair, Mark L Levitt, Jennifer L Leiting, Amro M Abdelrahman, Xinli Zhu, Fabrice Lucien, Mark J Truty, Lewis R Roberts
Upamostat is an orally available small-molecule serine protease inhibitor that is a highly potent inhibitor of trypsin 1, trypsin 2, trypsin 3 (PRSS1/2/3), and the urokinase-type plasminogen activator (uPA). These enzymes are expressed in many cancers, especially during tissue remodeling and subsequent tumor cell invasion. Opaganib (ABC294640), a novel, orally available small molecule is a selective inhibitor of the phosphorylation of sphingosine to sphingosine-1-phosphate (S-1-P) by sphingosine kinase 2 (SPHK2)...
March 5, 2024: Cancers
https://read.qxmd.com/read/38469989/bornean-tropical-forests-recovering-from-logging-at-risk-of-regeneration-failure
#8
JOURNAL ARTICLE
David C Bartholomew, Robin Hayward, David F R P Burslem, Paulo R L Bittencourt, Daniel Chapman, Mohd Aminur Faiz Bin Suis, Reuben Nilus, Michael J O'Brien, Glen Reynolds, Lucy Rowland, Lindsay F Banin, Daisy Dent
Active restoration through silvicultural treatments (enrichment planting, cutting climbers and liberation thinning) is considered an important intervention in logged forests. However, its ability to enhance regeneration is key for long-term recovery of logged forests, which remains poorly understood, particularly for the production and survival of seedlings in subsequent generations. To understand the long-term impacts of logging and restoration we tracked the diversity, survival and traits of seedlings that germinated immediately after a mast fruiting in North Borneo in unlogged and logged forests 30-35 years after logging...
March 2024: Global Change Biology
https://read.qxmd.com/read/38456111/the-brain-economy-advancing-brain-science-to-better-understand-the-modern-economy
#9
EDITORIAL
Harris A Eyre, William Hynes, Rym Ayadi, Pawel Swieboda, Michael Berk, Agustin Ibanez, María E Castelló, Dilip V Jeste, Michelle Tempest, Jafri Malin Abdullah, Kelly O'Brien, Steve Carnevale, Alfred K Njamnshi, Michael Martino, Dan Mannix, Katrina Maestri, Ruojuan Yu, Shuo Chen, Chee H Ng, Heinrich C Volmink, Rajiv Ahuja, Frederic Destrebecq, George Vradenburg, Astrid Schmied, Facundo Manes, Michael L Platt
The coming years are likely to be turbulent due to a myriad of factors or polycrisis, including an escalation in climate extremes, emerging public health threats, weak productivity, increases in global economic instability and further weakening in the integrity of global democracy. These formidable challenges are not exogenous to the economy but are in some cases generated by the system itself. They can be overcome, but only with far-reaching changes to global economics. Our current socio-economic paradigm is insufficient for addressing these complex challenges, let alone sustaining human development, well-being and happiness...
February 2024: Malaysian Journal of Medical Sciences: MJMS
https://read.qxmd.com/read/38455057/il11-mediated-stromal-cell-activation-may-not-be-the-master-regulator-of-pro-fibrotic-signaling-downstream-of-tgf%C3%AE
#10
JOURNAL ARTICLE
Yunhao Tan, Kenta Mosallanejad, Qingxiu Zhang, Stephen O'Brien, Meghan Clements, Stuart Perper, Sarah Wilson, Sudiksha Chaulagain, Jing Wang, Mary Abdalla, Helen Al-Saidi, Danyal Butt, Anca Clabbers, Kwasi Ofori, Beth Dillon, Bohdan Harvey, John Memmott, Christopher Negron, David Winarta, Catherine Tan, Amlan Biswas, Feng Dong, Vanessa Morales-Tirado, Xiaoqing Lu, Gurminder Singh, Michael White, Shanna Ashley, Heather Knight, Susan Westmoreland, Lucy Phillips, Tracy Carr, Lauren Reinke-Breen, Rajeeva Singh, Jianwen Xu, Kan Wu, Lisa Rinaldi, Brian Stoll, Yupeng David He, Lisa Hazelwood, Jozsef Karman, Andrew McCluskey, William Stine, Ivan Correia, Stephen Gauld, Marc C Levesque, Geertruida Veldman, Cedric Hubeau, Timothy Radstake, Ramkrishna Sadhukhan, Edda Fiebiger
Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need. Interleukin 11 (IL11)-mediated cell activation has been identified as a central mechanism for promoting fibrosis downstream of TGFβ. IL11 signaling has recently been reported to promote fibroblast-to-myofibroblast transition, thus leading to various pro-fibrotic phenotypic changes. We confirmed increased mRNA expression of IL11 and IL11Rα in fibrotic diseases by OMICs approaches and in situ hybridization...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38448198/can-critical-care-transport-be-safely-reduced-in-children-intubated-during-emergency-management-of-status-epilepticus-in-the-united-kingdom-a-national-audit-with-case-control-analysis
#11
JOURNAL ARTICLE
Philip Knight, Victoria Norman, Rochelle Gully, Dora Wood, Dusan Raffaj, Laura Riddick, Stephen Hancock, Sanjay Revanna, Mohammed Uvaise, Sasha Herring, Mark Worrall, Ashley Daye, Mark Terris, Cormac O'Brien, Ananth Kumar, Sophie Scott, Lisa Pritchard, Srinivasan Palaniappan, Charlotte Hughes, Michael J Griksaitis, Shelley Riphagen, Padmanabhan Ramnarayan
OBJECTIVE: This study describes the baseline clinical characteristics, predictors of successful extubation at referring hospitals and short-term outcomes of children intubated for status epilepticus and referred to United Kingdom (UK) paediatric critical care transport teams (PCCTs). DESIGN: Multicentre audit with case-control analysis, conducted between 1 September 2018 and 1 September 2020. SETTING: This study involved 10 UK PCCTs. PATIENTS: Children over 1 month of age intubated during emergency management for status epilepticus (SE), referred to UK PCCTs...
March 6, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38447116/acute-pulmonary-injury-in-hematology-patients-supported-with-pathogen-reduced-and-conventional-platelet-components
#12
JOURNAL ARTICLE
Allison P Wheeler, Edward L Snyder, Majed A Refaai, Claudia S Cohn, Jessica Poisson, Magali J Fontaine, Mary Sehl, Ajay K Nooka, Lynne Uhl, Phillip C Spinella, Maly Fenelus, Darla K Liles, Thomas Coyle, Joanne Becker, Michael Raymond Jeng, Eric A Gehrie, Bryan R Spencer, Pampee P Young, Andrew David Johnson, Jennifer O'Brien, Gary J Schiller, John D Roback, Elizabeth Malynn, Ronald Jackups, Scott Avecilla, Kathy Liu, Stanley Bentow, Jeanne Varrone, Richard J Benjamin, Laurence Corash
Patients treated with anti-neoplastic therapy often develop thrombocytopenia requiring platelet transfusion which has potential to exacerbate pulmonary injury. This study tested the hypothesis that amotosalen-UVA pathogen reduced platelet components (PRPC) do not potentiate pulmonary dysfunction compared to conventional platelet components (CPC). A prospective, multi-center, open label, sequential cohort study evaluated the incidence of treatment emergent assisted mechanical ventilation initiated for pulmonary dysfunction (TEAMV-PD)...
March 6, 2024: Blood Advances
https://read.qxmd.com/read/38445749/a-systematic-review-of-the-impact-of-compression-therapy-on-quality-of-life-and-pain-among-people-with-a-venous-leg-ulcer
#13
REVIEW
Declan Patton, Pinar Avsar, Aicha Sayeh, Aglecia Budri, Tom O'Connor, Simone Walsh, Linda Nugent, Denis Harkin, Niall O'Brien, Jonathan Cayce, Michael Corcoran, Mario Gaztambide, Zena Moore
AIM: To gain a greater understanding of how compression therapy affects quality of life, this systematic review appraised existing published studies measuring the impact of compression therapy on health quality of life (HRQoL), and pain, among people with venous leg ulcers (VLU). METHOD: Five databases were searched, and two authors extracted data and appraised the quality of selected papers using the RevMan risk of bias tool. Due to heterogeneity in the types of compression and instruments used to evaluate HRQoL, meta-analysis was not appropriate; thus, a narrative synthesis of findings was undertaken...
March 2024: International Wound Journal
https://read.qxmd.com/read/38428643/pten-deficiency-induces-an-extrahepatic-cholangitis-cholangiocarcinoma-continuum-via-aurora-kinase-a-in-mice
#14
JOURNAL ARTICLE
Yan Yang, Jiale Wang, Jianhua Wan, Qianqian Cheng, Zenong Cheng, Xueli Zhou, Oliver Wang, Kelvin Shi, Lingxiang Wang, Bin Wang, Xiaohui Zhu, Jiaxiang Chen, Dongfeng Feng, Yang Liu, Yasmin Jahan-Mihan, Ashley N Haddock, Brandy H Edenfield, Guang Peng, Jessica D Hohenstein, Chantal E McCabe, Daniel R O'Brien, Chen Wang, Sumera I Ilyas, Liuyan Jiang, Michael S Torbenson, Huamin Wang, Raouf E Nakhleh, Xuemei Shi, Ying Wang, Yan Bi, Gregory J Gores, Tushar Patel, Baoan Ji
BACKGROUND & AIMS: The PTEN-AKT pathway is frequently altered in extrahepatic cholangiocarcinoma (eCCA). We aim to evaluate the role of PTEN in the pathogenesis of eCCA and find novel therapies for this disease. METHODS: The Pten gene in the biliary epithelial cells were genetically deleted using the Cre-loxp system. The pathologies were evaluated both macroscopically and histologically. The characteristics were further analyzed by immunohistochemistry (IHC), RT-PCR, cell culture, and RNAseq...
February 28, 2024: Journal of Hepatology
https://read.qxmd.com/read/38426071/safety-and-efficacy-of-whole-body-chlorhexidine-gluconate-cleansing-with-or-without-emollient-in-hospitalised-neonates-neochg-a-multicentre-randomised-open-label-factorial-pilot-trial
#15
JOURNAL ARTICLE
Neal Russell, Michelle N Clements, Kazi Shammin Azmery, Adrie Bekker, Julia Bielicki, Angela Dramowski, Sally Ellis, Aaqilah Fataar, Mahbubul Hoque, Kristen LeBeau, Seamus O'Brien, Francesca Schiavone, Peter Skoutari, Mohammad Shahidul Islam, Samir K Saha, Ann Sarah Walker, Andrew Whitelaw, Michael Sharland
BACKGROUND: Healthcare-associated infections account for substantial neonatal in-hospital mortality. Chlorhexidine gluconate (CHG) whole body skin application could reduce sepsis by lowering bacterial colonisation density, although safety and optimal application regimen is unclear. Emollients, including sunflower oil, may independently improve skin condition, thereby reducing sepsis. We aimed to inform which concentration and frequency of CHG, with or without emollient, would best balance safety and the surrogate marker of efficacy of reduction in bacterial colonisation, to be taken forward in a future pragmatic trial evaluating clinical outcomes of sepsis and mortality...
March 2024: EClinicalMedicine
https://read.qxmd.com/read/38422782/identifying-parkinsonism-in-mild-cognitive-impairment
#16
JOURNAL ARTICLE
Rishira Fernando, Alan J Thomas, Calum A Hamilton, Rory Durcan, Sally Barker, Joanna Ciafone, Nicola Barnett, Kirsty Olsen, Michael Firbank, Gemma Roberts, Jim Lloyd, George Petrides, Sean Colloby, Louise M Allan, Ian G McKeith, John T O'Brien, John-Paul Taylor, Paul C Donaghy
INTRODUCTION: Clinical parkinsonism is a core diagnostic feature for mild cognitive impairment with Lewy bodies (MCI-LB) but can be challenging to identify. A five-item scale derived from the Unified Parkinson's Disease Rating Scale (UPDRS) has been recommended for the assessment of parkinsonism in dementia. This study aimed to determine whether the five-item scale is effective to identify parkinsonism in MCI. METHODS: Participants with MCI from two cohorts (n = 146) had a physical examination including the UPDRS and [123I]-FP-CIT SPECT striatal dopaminergic imaging...
February 15, 2024: Journal of the Neurological Sciences
https://read.qxmd.com/read/38422128/a-far-ultraviolet-driven-photoevaporation-flow-observed-in-a-protoplanetary-disk
#17
JOURNAL ARTICLE
Olivier Berné, Emilie Habart, Els Peeters, Ilane Schroetter, Amélie Canin, Ameek Sidhu, Ryan Chown, Emeric Bron, Thomas J Haworth, Pamela Klaassen, Boris Trahin, Dries Van De Putte, Felipe Alarcón, Marion Zannese, Alain Abergel, Edwin A Bergin, Jeronimo Bernard-Salas, Christiaan Boersma, Jan Cami, Sara Cuadrado, Emmanuel Dartois, Daniel Dicken, Meriem Elyajouri, Asunción Fuente, Javier R Goicoechea, Karl D Gordon, Lina Issa, Christine Joblin, Olga Kannavou, Baria Khan, Ozan Lacinbala, David Languignon, Romane Le Gal, Alexandros Maragkoudakis, Raphael Meshaka, Yoko Okada, Takashi Onaka, Sofia Pasquini, Marc W Pound, Massimo Robberto, Markus Röllig, Bethany Schefter, Thiébaut Schirmer, Thomas Simmer, Benoit Tabone, Alexander G G M Tielens, Sílvia Vicente, Mark G Wolfire, Isabel Aleman, Louis Allamandola, Rebecca Auchettl, Giuseppe Antonio Baratta, Clément Baruteau, Salma Bejaoui, Partha P Bera, John H Black, Francois Boulanger, Jordy Bouwman, Bernhard Brandl, Philippe Brechignac, Sandra Brünken, Mridusmita Buragohain, Andrew Burkhardt, Alessandra Candian, Stéphanie Cazaux, Jose Cernicharo, Marin Chabot, Shubhadip Chakraborty, Jason Champion, Sean W J Colgan, Ilsa R Cooke, Audrey Coutens, Nick L J Cox, Karine Demyk, Jennifer Donovan Meyer, Cécile Engrand, Sacha Foschino, Pedro García-Lario, Lisseth Gavilan, Maryvonne Gerin, Marie Godard, Carl A Gottlieb, Pierre Guillard, Antoine Gusdorf, Patrick Hartigan, Jinhua He, Eric Herbst, Liv Hornekaer, Cornelia Jäger, Eduardo Janot-Pacheco, Michael Kaufman, Francisca Kemper, Sarah Kendrew, Maria S Kirsanova, Collin Knight, Sun Kwok, Álvaro Labiano, Thomas S-Y Lai, Timothy J Lee, Bertrand Lefloch, Franck Le Petit, Aigen Li, Hendrik Linz, Cameron J Mackie, Suzanne C Madden, Joëlle Mascetti, Brett A McGuire, Pablo Merino, Elisabetta R Micelotta, Jon A Morse, Giacomo Mulas, Naslim Neelamkodan, Ryou Ohsawa, Roberta Paladini, Maria Elisabetta Palumbo, Amit Pathak, Yvonne J Pendleton, Annemieke Petrignani, Thomas Pino, Elena Puga, Naseem Rangwala, Mathias Rapacioli, Alessandra Ricca, Julia Roman-Duval, Evelyne Roueff, Gaël Rouillé, Farid Salama, Dinalva A Sales, Karin Sandstrom, Peter Sarre, Ella Sciamma-O'Brien, Kris Sellgren, Matthew J Shannon, Adrien Simonnin, Sachindev S Shenoy, David Teyssier, Richard D Thomas, Aditya Togi, Laurent Verstraete, Adolf N Witt, Alwyn Wootten, Nathalie Ysard, Henning Zettergren, Yong Zhang, Ziwei E Zhang, Junfeng Zhen
Most low-mass stars form in stellar clusters that also contain massive stars, which are sources of far-ultraviolet (FUV) radiation. Theoretical models predict that this FUV radiation produces photodissociation regions (PDRs) on the surfaces of protoplanetary disks around low-mass stars, which affects planet formation within the disks. We report James Webb Space Telescope and Atacama Large Millimeter Array observations of a FUV-irradiated protoplanetary disk in the Orion Nebula. Emission lines are detected from the PDR; modeling their kinematics and excitation allowed us to constrain the physical conditions within the gas...
March 2024: Science
https://read.qxmd.com/read/38411286/patterns-of-subregional-cerebellar-atrophy-across-epilepsy-syndromes-an-enigma-epilepsy-study
#18
JOURNAL ARTICLE
Rebecca Kerestes, Andrew Perry, Lucy Vivash, Terence J O'Brien, Marina K M Alvim, Donatello Arienzo, Ítalo K Aventurato, Alice Ballerini, Gabriel F Baltazar, Núria Bargalló, Benjamin Bender, Ricardo Brioschi, Eva Bürkle, Maria Eugenia Caligiuri, Fernando Cendes, Jane de Tisi, John S Duncan, Jerome P Engel, Sonya Foley, Francesco Fortunato, Antonio Gambardella, Thea Giacomini, Renzo Guerrini, Gerard Hall, Khalid Hamandi, Victoria Ives-Deliperi, Rafael B João, Simon S Keller, Benedict Kleiser, Angelo Labate, Matteo Lenge, Cassandra Marotta, Pascal Martin, Mario Mascalchi, Stefano Meletti, Conor Owens-Walton, Costanza B Parodi, Saül Pascual-Diaz, David Powell, Jun Rao, Michael Rebsamen, Johannes Reiter, Antonella Riva, Theodor Rüber, Christian Rummel, Freda Scheffler, Mariasavina Severino, Lucas S Silva, Richard J Staba, Dan J Stein, Pasquale Striano, Peter N Taylor, Sophia I Thomopoulos, Paul M Thompson, Domenico Tortora, Anna Elisabetta Vaudano, Bernd Weber, Roland Wiest, Gavin P Winston, Clarissa L Yasuda, Hong Zheng, Carrie R McDonald, Sanjay M Sisodiya, Ian H Harding
OBJECTIVE: The intricate neuroanatomical structure of the cerebellum is of longstanding interest in epilepsy, but has been poorly characterized within the current corticocentric models of this disease. We quantified cross-sectional regional cerebellar lobule volumes using structural magnetic resonance imaging in 1602 adults with epilepsy and 1022 healthy controls across 22 sites from the global ENIGMA-Epilepsy working group. METHODS: A state-of-the-art deep learning-based approach was employed that parcellates the cerebellum into 28 neuroanatomical subregions...
February 27, 2024: Epilepsia
https://read.qxmd.com/read/38410945/sex-differences-in-revascularization-treatment-goals-and-outcomes-of-patients-with-chronic-coronary-disease-insights-from-the-ischemia-trial
#19
JOURNAL ARTICLE
Harmony R Reynolds, Derek D Cyr, C Noel Bairey Merz, Leslee J Shaw, Bernard R Chaitman, William E Boden, Karen P Alexander, Yves D Rosenberg, Sripal Bangalore, Gregg W Stone, Claes Held, John Spertus, Kaatje Goetschalckx, Olga Bockeria, Jonathan D Newman, Jeffrey S Berger, Ahmed Elghamaz, Renato D Lopes, James K Min, Daniel S Berman, Michael H Picard, Raymond Y Kwong, Robert A Harrington, Boban Thomas, Sean M O'Brien, David J Maron, Judith S Hochman
BACKGROUND: Women with chronic coronary disease are generally older than men and have more comorbidities but less atherosclerosis. We explored sex differences in revascularization, guideline-directed medical therapy, and outcomes among patients with chronic coronary disease with ischemia on stress testing, with and without invasive management. METHODS AND RESULTS: The ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial randomized patients with moderate or severe ischemia to invasive management with angiography, revascularization, and guideline-directed medical therapy, or initial conservative management with guideline-directed medical therapy alone...
February 27, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38399319/dual-glyoxalase-1-and-%C3%AE-klotho-gene-activated-scaffold-reduces-methylglyoxal-and-reprograms-diabetic-adipose-derived-stem-cells-prospects-in-improved-wound-healing
#20
JOURNAL ARTICLE
Nadia Pang, Ashang L Laiva, Noof Z Sulaiman, Priya Das, Fergal J O'Brien, Michael B Keogh
Tissue engineering approaches aim to provide biocompatible scaffold supports that allow healing to progress often in healthy tissue. In diabetic foot ulcers (DFUs), hyperglycemia impedes ulcer regeneration, due to complications involving accumulations of cellular methylglyoxal (MG), a key component of oxidated stress and premature cellular aging which further limits repair. In this study, we aim to reduce MG using a collagen-chondroitin sulfate gene-activated scaffold (GAS) containing the glyoxalase-1 gene (GLO-1) to scavenge MG and anti-fibrotic β-klotho to restore stem cell activity in diabetic adipose-derived stem cells (dADSCs)...
February 13, 2024: Pharmaceutics
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