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JOURNAL ARTICLE
Vera H J van Hal, Jan-Willem Muller, Marc R H M van Sambeek, Richard G P Lopata, Hans-Martin Schwab
Abdominal ultrasound image quality is hampered by phase aberration, that is mainly caused by the large speed-of-sound (SoS) differences between fat and muscle tissue in the abdominal wall. The mismatch between the assumed and actual SoS distribution introduces general blurring of the ultrasound images, and acoustic refraction can lead to geometric distortion of the imaged features. Large aperture imaging or dual-transducer imaging can improve abdominal imaging at deep locations by providing increased contrast and resolution...
February 7, 2023: Ultrasonics
#22
Bhuwan Khatri, Kandice L Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A Aqrawi, Eva Baecklund, Johan G Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglænd Johnsen, Malin V Jonsson, Marika Kvarnström, Jennifer A Kelly, He Li, Thomas Mandl, Javier Martín, Gaétane Nocturne, Katrine Brække Norheim, Øyvind Palm, Kathrine Skarstein, Anna M Stolarczyk, Kimberly E Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J Wallace, Kiely M Grundahl, Kimberly S Hefner, Lida Radfar, David M Lewis, Donald U Stone, C Erick Kaufman, Michael T Brennan, Joel M Guthridge, Judith A James, R Hal Scofield, Patrick M Gaffney, Lindsey A Criswell, Roland Jonsson, Per Eriksson, Simon J Bowman, Roald Omdal, Lars Rönnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A Darise Farris, Xavier Mariette, Marta E Alarcon-Riquelme, Caroline H Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J Lessard
No abstract text is available yet for this article.
February 3, 2023: Nature Communications
#23
JOURNAL ARTICLE
Deanna K Meinke, William Hal Martin
Ambient noise in the test environment will impact signal detection during hearing threshold measurements due to psychoacoustic masking effects. Technical standards specify the maximum permissible ambient noise levels (MPANLs) for use during audiometric testing. MPANLs are dependent on several factors, including transducer characteristics (supra-aural, circumaural, type of ear cushions or earphone enclosures, and insert earphones), the nature of the hearing test being performed (air conduction vs bone conduction and threshold test vs screen at a suprathreshold level), and measurement instrumentation...
January 2023: Journal of the Acoustical Society of America
#24
Bhuwan Khatri, Kandice L Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A Aqrawi, Eva Baecklund, Johan G Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglænd Johnsen, Malin V Jonsson, Marika Kvarnström, Jennifer A Kelly, He Li, Thomas Mandl, Javier Martín, Gaétane Nocturne, Katrine Brække Norheim, Øyvind Palm, Kathrine Skarstein, Anna M Stolarczyk, Kimberly E Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J Wallace, Kiely M Grundahl, Kimberly S Hefner, Lida Radfar, David M Lewis, Donald U Stone, C Erick Kaufman, Michael T Brennan, Joel M Guthridge, Judith A James, R Hal Scofield, Patrick M Gaffney, Lindsey A Criswell, Roland Jonsson, Per Eriksson, Simon J Bowman, Roald Omdal, Lars Rönnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A Darise Farris, Xavier Mariette, Marta E Alarcon-Riquelme, Caroline H Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J Lessard
No abstract text is available yet for this article.
October 31, 2022: Nature Communications
#25
JOURNAL ARTICLE
Jennifer W Leiding, Tiphanie P Vogel, Valentine G J Santarlas, Rahul Mhaskar, Madison R Smith, Alexandre Carisey, Alexander Vargas-Hernández, Manuel Silva-Carmona, Maximilian Heeg, Anne Rensing-Ehl, Bénédicte Neven, Jérôme Hadjadj, Sophie Hambleton, Timothy Ronan Leahy, Kornvalee Meesilpavikai, Charlotte Cunningham-Rundles, Cullen M Dutmer, Svetlana O Sharapova, Mervi Taskinen, Ignatius Chua, Rosie Hague, Christian Klemann, Larysa Kostyuchenko, Tomohiro Morio, Akaluck Thatayatikom, Ahmet Ozen, Anna Scherbina, Cindy S Bauer, Sarah E Flanagan, Eleonora Gambineri, Lisa Giovannini-Chami, Jennifer Heimall, Kathleen E Sullivan, Eric Allenspach, Neil Romberg, Sean G Deane, Benjamin T Prince, Melissa J Rose, John Bohnsack, Talal Mousallem, Rohith Jesudas, Maria Marluce Dos Santos Vilela, Michael O'Sullivan, Jana Pachlopnik Schmid, Štěpánka Průhová, Adam Klocperk, Matthew Rees, Helen Su, Sami Bahna, Safa Baris, Lisa M Bartnikas, Amy Chang Berger, Tracy A Briggs, Shannon Brothers, Vanessa Bundy, Alice Y Chan, Shanmuganathan Chandrakasan, Mette Christiansen, Theresa Cole, Matthew C Cook, Mukesh M Desai, Ute Fischer, David A Fulcher, Silvanna Gallo, Amelie Gauthier, Andrew R Gennery, José Gonçalo Marques, Frédéric Gottrand, Bodo Grimbacher, Eyal Grunebaum, Emma Haapaniemi, Sari Hämäläinen, Kaarina Heiskanen, Tarja Heiskanen-Kosma, Hal M Hoffman, Luis Ignacio Gonzalez-Granado, Anthony L Guerrerio, Leena Kainulainen, Ashish Kumar, Monica G Lawrence, Carina Levin, Timi Martelius, Olaf Neth, Peter Olbrich, Alejandro Palma, Niraj C Patel, Tamara Pozos, Kahn Preece, Saúl Oswaldo Lugo Reyes, Mark A Russell, Yael Schejter, Christine Seroogy, Jan Sinclair, Effie Skevofilax, Daniel Suan, Daniel Suez, Paul Szabolcs, Helena Velasco, Klaus Warnatz, Kelly Walkovich, Austen Worth, Mikko R J Seppänen, Troy R Torgerson, Georgios Sogkas, Stephan Ehl, Stuart G Tangye, Megan A Cooper, Joshua D Milner, Lisa R Forbes Satter
BACKGROUND: In 2014, germline signal transducer and activator of transcription (STAT) 3 gain-of-function (GOF) mutations were first described to cause a novel multisystem disease of early-onset lymphoproliferation and autoimmunity. OBJECTIVE: This pivotal cohort study defines the scope, natural history, treatment, and overall survival of a large global cohort of patients with pathogenic STAT3 GOF variants. METHODS: We identified 191 patients from 33 countries with 72 unique mutations...
April 2023: Journal of Allergy and Clinical Immunology
#26
JOURNAL ARTICLE
Reference equivalent threshold sound pressure levels for the Wireless Automated Hearing Test System.
Odile H Clavier, James A Norris, David W Hinckley, William Hal Martin, Shi Yuan Lee, Sigfrid D Soli, Douglas S Brungart, Jaclyn R Schurman, Erik Larsen, Golbarg Mehraei, Tera M Quigley
This paper presents reference equivalent threshold sound pressure levels (RETSPLs) for the Wireless Automated Hearing Test System (WAHTS), a recently commercialized device developed for use as a boothless audiometer. Two initial studies were conducted following the ISO 389-9 standard [ISO 389-9 (2009). "Acoustics-Reference zero for the calibration of audiometric equipment. Part 9: Preferred test conditions for the determinations of reference hearing threshold levels" (International Organization for Standardization, Geneva)]...
July 2022: Journal of the Acoustical Society of America
#27
JOURNAL ARTICLE
Bhuwan Khatri, Kandice L Tessneer, Astrid Rasmussen, Farhang Aghakhanian, Tove Ragna Reksten, Adam Adler, Ilias Alevizos, Juan-Manuel Anaya, Lara A Aqrawi, Eva Baecklund, Johan G Brun, Sara Magnusson Bucher, Maija-Leena Eloranta, Fiona Engelke, Helena Forsblad-d'Elia, Stuart B Glenn, Daniel Hammenfors, Juliana Imgenberg-Kreuz, Janicke Liaaen Jensen, Svein Joar Auglænd Johnsen, Malin V Jonsson, Marika Kvarnström, Jennifer A Kelly, He Li, Thomas Mandl, Javier Martín, Gaétane Nocturne, Katrine Brække Norheim, Øyvind Palm, Kathrine Skarstein, Anna M Stolarczyk, Kimberly E Taylor, Maria Teruel, Elke Theander, Swamy Venuturupalli, Daniel J Wallace, Kiely M Grundahl, Kimberly S Hefner, Lida Radfar, David M Lewis, Donald U Stone, C Erick Kaufman, Michael T Brennan, Joel M Guthridge, Judith A James, R Hal Scofield, Patrick M Gaffney, Lindsey A Criswell, Roland Jonsson, Per Eriksson, Simon J Bowman, Roald Omdal, Lars Rönnblom, Blake Warner, Maureen Rischmueller, Torsten Witte, A Darise Farris, Xavier Mariette, Marta E Alarcon-Riquelme, Caroline H Shiboski, Marie Wahren-Herlenius, Wan-Fai Ng, Kathy L Sivils, Indra Adrianto, Gunnel Nordmark, Christopher J Lessard
Sjögren's disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren's cases of European ancestry: CD247, NAB1, PTTG1-MIR146A, PRDM1-ATG5, TNFAIP3, XKR6, MAPT-CRHR1, RPTOR-CHMP6-BAIAP6, TYK2, SYNGR1. Polygenic risk scores yield predictability (AUROC = 0.71) and relative risk of 12.08. Interrogation of bioinformatics databases refine the associations, define local regulatory networks of GWS SNPs from the 95% credible set, and expand the implicated gene list to >40...
July 27, 2022: Nature Communications
#28
EDITORIAL
Yongjin Zhou, Martin Grininger, Hal Alper
No abstract text is available yet for this article.
December 2022: Synthetic and Systems Biotechnology
#29
JOURNAL ARTICLE
Richard Feng, Munif Hatem, Scott J Nimmons, Ashley Disantis, RobRoy L Martin, Hal David Martin
The association between hip and spine abnormalities is frequent, and limitation in hip extension has been linked with low back pain. The purpose of this study was to assess the radiographic osseous findings in nonarthritic hips of patients with hip pain, low back pain, and limited hip extension. Ninety patients (92 hips) were included in this study. Hip extension was tested in the contralateral decubitus position with the hip in neutral abduction/adduction and neutral rotation. In sequence, hip extension was tested by adding passive abduction, followed by internal/external rotation of the hip...
2022: Proceedings of the Baylor University Medical Center
#30
REVIEW
Nicole Töpfner, Martin Alberer, Tobias Ankermann, Stephan Bender, Reinhard Berner, Jan de Laffolie, Jens Dingemann, Dirk Heinicke, Johannes Peter Haas, Markus Hufnagel, Thomas Hummel, Hans-Iko Huppertz, Markus Knuf, Robin Kobbe, Thomas Lücke, Joachim Riedel, Josef Rosenecker, Joachim Wölfle, Barbara Schneider, Dominik Schneider, Valentin Schriever, Anne Schroeder, Silvia Stojanov, Tobias Tenenbaum, Stefan Trapp, Daniel Vilser, Folke Brinkmann, Uta Behrends
This current consensus paper for long COVID complements the existing AWMF S1 guidelines for long COVID with a detailed overview on the various clinical aspects of long COVID in children and adolescents. Members of 19 different pediatric societies of the DGKJ convent and collaborating societies together provide expert-based recommendations for the clinical management of long COVID based on the currently available but limited academic evidence for long COVID in children and adolescents. It contains screening questions for long COVID and suggestions for a structured, standardized pediatric medical history and diagnostic evaluation for patients with suspected long COVID...
2022: Monatsschrift Kinderheilkunde: Organ der Deutschen Gesellschaft Für Kinderheilkunde
#31
JOURNAL ARTICLE
Anupriya Aggarwal, Alberto Ospina Stella, Gregory Walker, Anouschka Akerman, Camille Esneau, Vanessa Milogiannakis, Deborah L Burnett, Samantha McAllery, Mariana Ruiz Silva, Yonghui Lu, Charles S P Foster, Fabienne Brilot, Aleha Pillay, Sabastiaan Van Hal, Vennila Mathivanan, Christina Fichter, Andrea Kindinger, Alexandra Carey Hoppe, Mee Ling Munier, Supavadee Amatayakul-Chantler, Nathan Roth, Germano Coppola, Geoff P Symonds, Peter Schofield, Jennifer Jackson, Helen Lenthall, Jake Y Henry, Ohan Mazigi, Hans-Martin Jäck, Miles P Davenport, David R Darley, Gail V Matthews, David S Khoury, Deborah Cromer, Christopher C Goodnow, Daniel Christ, Roselle Robosa, Damien J Starck, Nathan W Bartlett, William D Rawlinson, Anthony D Kelleher, Stuart G Turville
Genetically distinct variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged since the start of the COVID-19 pandemic. Over this period, we developed a rapid platform (R-20) for viral isolation and characterization using primary remnant diagnostic swabs. This, combined with quarantine testing and genomics surveillance, enabled the rapid isolation and characterization of all major SARS-CoV-2 variants circulating in Australia in 2021. Our platform facilitated viral variant isolation, rapid resolution of variant fitness using nasopharyngeal swabs and ranking of evasion of neutralizing antibodies...
June 2022: Nature Microbiology
#32
JOURNAL ARTICLE
Franco Maggiolo, Giuliano Rizzardini, Jean-Michel Molina, Federico Pulido, Stephane De Wit, Linos Vandekerckhove, Juan Berenguer, Michelle L D'Antoni, Christiana Blair, Susan K Chuck, David Piontkowsky, Hal Martin, Richard Haubrich, Ian R McNicholl, Joel Gallant
OBJECTIVES: Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) is an effective treatment for HIV-1 infection; however, clinical trial data in older people living with HIV (PLWH) are lacking. The primary 24-week and secondary 48-week analyses of study GS-US-380-4449 (NCT03405935), which assessed the efficacy and safety of switching to B/F/TAF in older PLWH, have been published. Here we report the results of the final 96-week analyses from the study. METHODS: In this 96-week, phase 3b, open-label, single-arm trial, virologically suppressed PLWH aged ≥65 years switched from elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide or a tenofovir disoproxil fumarate-based regimen to B/F/TAF...
May 8, 2022: HIV Medicine
#33
JOURNAL ARTICLE
Pilar Mata-Romero, Daniel Martín-Holgado, Hal C Ferreira-Nossa, Pedro L González-Cordero, Ana Izquierdo-Martín, Patricia Barros-García, Nuria Fernandez-Gonzalez, Luis Fernández-Pereira, Carmen Cámara-Hijón, Javier Molina-Infante
BACKGROUND: Ultra-short coeliac disease (USCD) is a novel celiac disease (CD) subtype limited to the duodenal bulb (D1). HLA haplotypes and flow cytometry have not been assessed yet. AIMS: To compare genetic, clinical, serologic, histopathologic and inmmunophenotypic parameters between USCD and conventional celiac disease (CCD) patients. METHODS: Prospective single-center study in children and adult patients undergoing duodenal biopsies on a gluten-containing diet...
November 2022: Gastroenterología y Hepatología
#34
JOURNAL ARTICLE
Paul E Sax, Kristen Andreatta, Jean-Michel Molina, Eric S Daar, Debbie Hagins, Rima Acosta, Michelle L D'Antoni, Silvia Chang, Ross Martin, Hui Liu, Christiana Blair, Ian McNicholl, Joel Gallant, Sean E Collins, Hal Martin, Kirsten L White
OBJECTIVE: We investigated the prevalence of preexisting M184V/I and associated risk factors among clinical trial participants with suppressed HIV and evaluated the impact of M184V/I on virologic response after switching to bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF). DESIGN: Participant data were pooled from six clinical trials investigating the safety and efficacy of switching to B/F/TAF in virologically suppressed people with HIV. METHODS: Preexisting drug resistance was assessed by historical genotypes and/or baseline proviral DNA genotyping...
September 1, 2022: AIDS
#35
JOURNAL ARTICLE
R Hal Scofield, Valerie M Lewis, Joshua Cavitt, Biji T Kurien, Shervin Assassi, Javier Martin, Olga Gorlova, Peter Gregersen, Annette Lee, Lisa G Rider, Terrance O'Hanlon, Simon Rothwell, James Lilleker, Yuta Kochi, Chikacshi Terao, Ann Igoe, Wendy Stevens, Joanne Sahhar, Janet Roddy, Maureen Rischmueller, Sue Lester, Susanna Proudman, Sixia Chen, Matthew A Brown, Maureen D Mayes, Janine A Lamb, Frederick W Miller
OBJECTIVE: We undertook this study to examine the X chromosome complement in participants with systemic sclerosis (SSc) as well as idiopathic inflammatory myopathies. METHODS: The participants met classification criteria for the diseases. All participants underwent single-nucleotide polymorphism typing. We examined X and Y single-nucleotide polymorphism heterogeneity to determine the number of X chromosomes. For statistical comparisons, we used χ2 analyses with calculation of 95% confidence intervals...
June 2022: ACR open rheumatology
#36
JOURNAL ARTICLE
Martin Sillence, Alexandra Meier, Melody de Laat, Rebecca Klee, Dania Reiche
BACKGROUND: Although several studies have investigated factors associated with the onset and occurrence of hyperinsulinaemia-associated laminitis (HAL), few have examined the factors associated with the rate of improvement during recovery from an acute bout of the disease. This observational study sought to discover if a range of demographic, morphologic, hormonal and metabolic variables are associated with the improvement rate from HAL in 37 naturally-occurring cases identified by 16 clinics across Germany...
January 18, 2022: BMC Veterinary Research
#37
JOURNAL ARTICLE
A Ross Brown, Martin K S Lilley, Jamie Shutler, Claire Widdicombe, Paul Rooks, Andrea McEvoy, Ricardo Torres, Yuri Artioli, Gary Rawle, John Homyard, Charles R Tyler, Chris Lowe
Harmful algal blooms (HABs) can have severe ecological, societal and economic impacts upon marine ecosystems, human health and the seafood industry. We evaluated changes in marine plankton communities with prevailing physico-chemical conditions throughout an exceptionally warm summer (2018), to elucidate key factors governing HABs and their impacts on shellfish mariculture in the western English Channel. Despite warm, stable weather conditions and widespread seasonal stratification throughout the summer, divergent plankton community compositions were observed at two rope-grown mussel (Mytilus edulis) farms (St Austell Bay and Lyme Bay) and a long-term ecological research LTER site (Plymouth L4)...
January 2022: Harmful Algae
#38
JOURNAL ARTICLE
Sarah Zimmermann, Elisheva van der Hal, Martin Auerbach, Danny Brom, Liron Ben-Ezra, Randy Tischler, Liora Cassif-Weissberg, Reut Nof, Simon Forstmeier
Having reached the last phase of their lives, many Holocaust survivors (HS) experience an increase in vulnerability. Despite their remarkable ability to adapt, the process of aging presents them with new challenges, often leading to an increased need for therapy. This is made all the more difficult by the fact that there is little research on trauma therapy in old age. To date, no randomized controlled study has been carried out to examine the effectiveness of psychotherapy in HS. The present case studies report the implementation of life review therapy (LRT-HS) undertaken with two female HS with symptoms of post-traumatic stress disorder (PTSD)...
December 23, 2021: Psychotherapy
#39
JOURNAL ARTICLE
Michelle L D'Antoni, Kristen Andreatta, Rima Acosta, Hal Martin, Silvia Chang, Ross Martin, Kirsten L White
BACKGROUND: Preexisting drug resistance limits the utility of HIV antiretroviral therapy. Studies have demonstrated safety and efficacy of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), including in patients with M184V/I substitutions. SETTING: We investigated virologic outcomes through 48 weeks of B/F/TAF treatment in individuals with preexisting primary integrase strand transfer inhibitor resistance (INSTI-R). METHODS: Preexisting INSTI-R was retrospectively evaluated from 7 B/F/TAF studies...
April 1, 2022: Journal of Acquired Immune Deficiency Syndromes: JAIDS
#40
RANDOMIZED CONTROLLED TRIAL
Michael Gnant, Amylou C Dueck, Sophie Frantal, Miguel Martin, Hal J Burstein, Richard Greil, Peter Fox, Antonio C Wolff, Arlene Chan, Eric P Winer, Georg Pfeiler, Kathy D Miller, Marco Colleoni, Jennifer M Suga, Gabor Rubovsky, Judith M Bliss, Ingrid A Mayer, Christian F Singer, Zbigniew Nowecki, Olwen Hahn, Jacqui Thomson, Norman Wolmark, Kepa Amillano, Hope S Rugo, Guenther G Steger, Blanca Hernando Fernández de Aránguiz, Tufia C Haddad, Antonia Perelló, Meritxell Bellet, Hannes Fohler, Otto Metzger Filho, Anita Jallitsch-Halper, Kadine Solomon, Céline Schurmans, Kathy P Theall, Dongrui R Lu, Kathleen Tenner, Christian Fesl, Angela DeMichele, Erica L Mayer
PURPOSE: Palbociclib is a cyclin-dependent kinase 4 and 6 inhibitor approved for advanced breast cancer. In the adjuvant setting, the potential value of adding palbociclib to endocrine therapy for hormone receptor-positive breast cancer has not been confirmed. PATIENTS AND METHODS: In the prospective, randomized, phase III PALLAS trial, patients with hormone receptor-positive, human epidermal growth factor receptor 2-negative early breast cancer were randomly assigned to receive 2 years of palbociclib (125 mg orally once daily, days 1-21 of a 28-day cycle) with adjuvant endocrine therapy or adjuvant endocrine therapy alone (for at least 5 years)...
January 20, 2022: Journal of Clinical Oncology
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