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Hal Martin

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https://www.readbyqxmd.com/read/28219610/bictegravir-versus-dolutegravir-each-with-emtricitabine-and-tenofovir-alafenamide-for-initial-treatment-of-hiv-1-infection-a-randomised-double-blind-phase-2-trial
#1
Paul E Sax, Edwin DeJesus, Gordon Crofoot, Douglas Ward, Paul Benson, Robin Dretler, Anthony Mills, Cynthia Brinson, Julie Peloquin, Xuelian Wei, Kirsten White, Andrew Cheng, Hal Martin, Erin Quirk
BACKGROUND: All recent treatment guidelines recommend integrase strand transfer inhibitors (INSTIs) as components of initial HIV therapy. Bictegravir, a novel, once-daily, unboosted INSTI, showed potent activity in a 10 day monotherapy study and has a high in-vitro resistance barrier. On the basis of these results, we did a phase 2 trial comparing bictegravir with dolutegravir. METHODS: In this randomised, double-blind, phase 2 trial, we recruited previously untreated adults (aged ≥18 years) with HIV-1 infections from 22 outpatient centres in the USA...
February 14, 2017: Lancet HIV
https://www.readbyqxmd.com/read/28219544/the-society-of-thoracic-surgeons-congenital-heart-surgery-database-2017-update-on-outcomes-and-quality
#2
Jeffrey P Jacobs, John E Mayer, Constantine Mavroudis, Sean M O'Brien, Erle H Austin, Sara K Pasquali, Kevin D Hill, David M Overman, James D St Louis, Tara Karamlou, Christian Pizarro, Jennifer C Hirsch-Romano, Donna McDonald, Jane M Han, Susan Becker, Christo I Tchervenkov, Francois Lacour-Gayet, Carl L Backer, Charles D Fraser, James S Tweddell, Martin J Elliott, Hal Walters, Richard A Jonas, Richard L Prager, David M Shahian, Marshall L Jacobs
The Society of Thoracic Surgeons Congenital Heart Surgery Database is the largest congenital and pediatric cardiac surgical clinical data registry in the world. It is the platform for all activities of The Society of Thoracic Surgeons related to the analysis of outcomes and the improvement of quality in this subspecialty. This report summarizes current aggregate national outcomes in congenital and pediatric cardiac surgery and reviews related activities in the areas of quality measurement, performance improvement, and transparency...
March 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28215378/program-sustainability-hearing-loss-and-tinnitus-prevention-in-american-indian-communities
#3
William Hal Martin, Judith L Sobel, Susan E Griest, Linda C Howarth, Thomas M Becker
INTRODUCTION: An important goal of any health promotion effort is to have it maintained in delivery and effectiveness over time. The purpose of this study was to establish a community-based noise-induced hearing loss and tinnitus prevention program in three different types of American Indian communities and evaluate them for evidence of long-term sustainability. METHODS: The target population was fourth- and fifth-grade students from three different models of American Indian communities...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28215376/hearing-related-health-among-adult-american-indians-from-a-pacific-northwest-tribe
#4
Kapuaolaokalaniakea Gellert, William Hal Martin, Jodi A Lapidus, Leslie Wosnig, Thomas M Becker
INTRODUCTION: Hearing loss and tinnitus are common in most populations, although few data have addressed hearing-related health among tribal members and the need for public health interventions. METHODS: This cross-sectional study examined prevalence and risk factors for hearing loss and tinnitus among 217 adults in a Pacific Northwest tribe. Frequency measures were conducted for difficulty hearing certain sounds and hearing aid use. In 2006, risk factors were examined for two outcomes-hearing loss and tinnitus-with analysis conducted in the same year...
March 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28196003/antiviral-activity-safety-and-pharmacokinetics-of-bictegravir-as-10-day-monotherapy-in-hiv-1-infected-adults
#5
Joel E Gallant, Melanie Thompson, Edwin DeJesus, Gene W Voskuhl, Xuelian Wei, Heather Zhang, Kirsten White, Andrew Cheng, Erin Quirk, Hal Martin
OBJECTIVE: to evaluate antiviral activity, safety, and pharmacokinetics of short-term monotherapy with bictegravir (bic), a novel, potent hiv integrase strand-transfer inhibitor (insti) DESIGN:: Phase 1b, randomized, double-blinded, adaptive, sequential cohort, placebo-controlled study METHODS:: HIV-infected adults not taking antiretroviral therapy were randomized to receive BIC (5, 25, 50, or 100 mg) or placebo once daily for 10 days. Primary endpoint was time-weighted average change from baseline to Day 11 (DAVG11) for plasma HIV-1 RNA...
February 8, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28165478/a-distinct-innate-lymphoid-cell-population-regulates-tumor-associated-t-cells
#6
Sarah Q Crome, Linh T Nguyen, Sandra Lopez-Verges, S Y Cindy Yang, Bernard Martin, Jennifer Y Yam, Dylan J Johnson, Jessica Nie, Michael Pniak, Pei Hua Yen, Anca Milea, Ramlogan Sowamber, Sarah Rachel Katz, Marcus Q Bernardini, Blaise A Clarke, Patricia A Shaw, Philipp A Lang, Hal K Berman, Trevor J Pugh, Lewis L Lanier, Pamela S Ohashi
Antitumor T cells are subject to multiple mechanisms of negative regulation. Recent findings that innate lymphoid cells (ILCs) regulate adaptive T cell responses led us to examine the regulatory potential of ILCs in the context of cancer. We identified a unique ILC population that inhibits tumor-infiltrating lymphocytes (TILs) from high-grade serous tumors, defined their suppressive capacity in vitro, and performed a comprehensive analysis of their phenotype. Notably, the presence of this CD56(+)CD3(-) population in TIL cultures was associated with reduced T cell numbers, and further functional studies demonstrated that this population suppressed TIL expansion and altered TIL cytokine production...
February 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28105847/compact-ultrahigh-pressure-nanoflow-capillary-liquid-chromatograph
#7
Xiaofeng Zhao, Xiaofeng Xie, Sonika Sharma, Luke T Tolley, Alex Plistil, Hal E Barnett, Martin P Brisbin, Adam C Swensen, John C Price, Paul B Farnsworth, H Dennis Tolley, Stanley D Stearns, Milton L Lee
A compact ultrahigh-pressure nanoflow liquid chromatograph (LC) was developed with the purpose in mind of creating a portable system that could be easily moved to various testing locations or placed in close proximity to other instruments for optimal coupling, such as with mass spectrometry (MS). The system utilized innovative nanoflow pumps integrated with a very low volume stop-flow injector and mixing tee. The system weighed only 5.9 kg (13 lbs) or 4.5 kg (10 lbs) without a controller and could hold up to 1100 bar (16000 psi) of pressure...
January 3, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28054324/corr-insights-%C3%A2-the-femoro-epiphyseal-acetabular-roof-fear-index-a-new-measurement-associated-with-instability-in-borderline-hip-dysplasia
#8
Hal David Martin
No abstract text is available yet for this article.
March 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27729164/preemptive-analgesia-in-hip-arthroscopy-a-randomized-controlled-trial-of-preemptive-periacetabular-or-intra-articular-bupivacaine-in-addition-to-postoperative-intra-articular-bupivacaine
#9
Amir Shlaifer, Zachary Tuvya Sharfman, Hal David Martin, Eyal Amar, Efi Kazum, Yaniv Warschawski, Matan Paret, Silviu Brill, Michael Drexler, Ehud Rath
PURPOSE: To evaluate and compare the efficacy of intra-articular and periacetabular blocks for postoperative pain control after hip arthroscopy. METHODS: Forty-two consecutive patients scheduled for hip arthroscopy were randomized into 2 postoperative pain control groups. One group received preemptive intra-articular 20 mL of bupivacaine 0.5% injection, and the second group received preemptive periacetabular 20 mL of bupivacaine 0.5% injection. Before closure all patients received an additional dose of 20 mL of bupivacaine 0...
January 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27720302/contribution-of-the-pubofemoral-ligament-to-hip-stability-a-biomechanical-study
#10
Hal D Martin, Anthony N Khoury, Ricardo Schröder, Eric Johnson, Juan Gómez-Hoyos, Salvador Campos, Ian J Palmer
PURPOSE: To determine the isolated function of the pubofemoral ligament of the hip capsule and its contribution to hip stability in external/internal rotational motion during flexion greater than 30° and abduction. METHODS: Thirteen hips from 7 fresh-frozen pelvis-to-toe cadavers were skeletonized from the lumbar spine to the distal femur with the capsular ligaments intact. Computed tomographic imaging was performed to ensure no occult pathological state existed, and assess bony anatomy...
February 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27624149/parallel-role-for-the-dopamine-d1-receptor-in-gambling-and-amphetamine-reinforcement-in-healthy-volunteers
#11
Martin H Zack, Daniela S Lobo, Candice Biback, Tim Fang, Kelly Smart, Daniel Tatone, Aditi Kalia, Daniel Digiacomo, James L Kennedy
This study investigated the role of dopamine, and specifically the D1 receptor (D1R), in the reinforcing effects of a slot-machine game in healthy volunteers (n=30). To compare gambling and drug effects, subjects received the prototypic psychostimulant drug d-amphetamine (AMPH; 20 mg) in a multi-session, placebo-controlled design. To isolate D1R, half the subjects were pretreated with the preferential D2 receptor antagonist haloperidol (HAL; 3 mg), and the other half with the mixed D1-D2 antagonist fluphenazine (FLU; 3 mg) before the game (Phase I) and AMPH (Phase II)...
September 13, 2016: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/27599822/the-hip-spine-effect-a-biomechanical-study-of-ischiofemoral-impingement-effect-on-lumbar-facet-joints
#12
Juan Gómez-Hoyos, Anthony Khoury, Ricardo Schröder, Eric Johnson, Ian J Palmer, Hal D Martin
PURPOSE: To assess the relation between ischiofemoral impingement (IFI) and lumbar facet joint load during hip extension in cadavers. METHODS: Twelve hips in 6 fresh T1-to-toes cadaveric specimens were tested. A complete pretesting imaging evaluation was performed using computed tomography scan. Cadavers were positioned in lateral decubitus and fixed to a dissection table. Both legs were placed on a frame in a simulated walking position. Through a posterior lumbar spine approach L3-4 and L4-5 facet joints were dissected bilaterally...
January 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27594331/editorial-commentary-arthroscopic-hip-preservation-is-critical-for-preserving-health-and-function-in-adolescents-and-adults
#13
EDITORIAL
Hal David Martin
Hip health is a critical factor in preserving daily life activities and wellbeing for both adults and adolescents. There are several potential economic influences in developing arthroscopic hip techniques for the evaluation and treatment of hip pathology in patients of all ages.
September 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27453504/an-exome-array-study-of-the-plasma-metabolome
#14
Eugene P Rhee, Qiong Yang, Bing Yu, Xuan Liu, Susan Cheng, Amy Deik, Kerry A Pierce, Kevin Bullock, Jennifer E Ho, Daniel Levy, Jose C Florez, Sek Kathiresan, Martin G Larson, Ramachandran S Vasan, Clary B Clish, Thomas J Wang, Eric Boerwinkle, Christopher J O'Donnell, Robert E Gerszten
The study of rare variants may enhance our understanding of the genetic determinants of the metabolome. Here, we analyze the association between 217 plasma metabolites and exome variants on the Illumina HumanExome Beadchip in 2,076 participants in the Framingham Heart Study, with replication in 1,528 participants of the Atherosclerosis Risk in Communities Study. We identify an association between GMPS and xanthosine using single variant analysis and associations between HAL and histidine, PAH and phenylalanine, and UPB1 and ureidopropionate using gene-based tests (P<5 × 10(-8) in meta-analysis), highlighting novel coding variants that may underlie inborn errors of metabolism...
July 25, 2016: Nature Communications
https://www.readbyqxmd.com/read/27354947/endoscopy-assisted-periacetabular-osteotomy
#15
Dean K Matsuda, Hal D Martin, Javad Parvizi
Minimizing soft tissue dissection and improving visualization of vital structures during periacetabular osteotomy (PAO) is of paramount importance to improve patient outcome and minimize complications. The endoscopy-assisted PAO was introduced to accomplish this objective. It involves an initial hip arthroscopy, for treatment of central compartment pathology, followed by a mini-open Bernese periacetabular osteotomy under fluoroscopic and endoscopic guidance, and completed by final dynamic hip arthroscopy to assess acetabular reorientation and fixation and to perform femoroplasty in relation to the new acetabular rim position, if needed...
April 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27343397/ischiofemoral-impingement-and-hamstring-syndrome-as-causes-of-posterior-hip-pain-where-do-we-go-next
#16
REVIEW
Hal David Martin, Anthony Khoury, Ricardo Schröder, Ian James Palmer
Recent advances in understanding hip joint anatomy and biomechanics have contributed to improvement of diagnosis and treatment decisions for distal causes of deep gluteal syndrome (DGS). Ischiofemoral impingement and hamstrings syndrome are sources of posterior hip pain that can simulate symptoms of DGS. The combination of a comprehensive history and physical examination with imaging and ancillary testing are critical for diagnosis. Six key physical examination tests are described to differentiate distal versus proximal sources of extrapelvic posterior hip pain...
July 2016: Clinics in Sports Medicine
https://www.readbyqxmd.com/read/27212048/capsulotomy-size-affects-hip-joint-kinematic-stability
#17
Thomas H Wuerz, Sang H Song, Jeffrey S Grzybowski, Hal D Martin, Richard C Mather, Michael J Salata, Alejandro A Espinoza Orías, Shane J Nho
PURPOSE: To evaluate the effect of capsulotomy size and subsequent repair on the biomechanical stability of hip joint kinematics through external rotation of a cadaveric hip in neutral flexion. METHODS: Eight fresh-frozen cadaveric hip specimens were used in this study. Each hip was tested under torsional loads of 6 N·m applied by a servohydraulic frame and transmitted by a pulley system. The test conditions were (1) neutral flexion with the capsule intact, (2) neutral flexion with a 4-cm interportal capsulotomy, (3) neutral flexion with a 6-cm capsulotomy, and (4) neutral flexion with capsulotomy repair...
August 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27025186/cediranib-in-patients-with-relapsed-platinum-sensitive-ovarian-cancer-icon6-a-randomised-double-blind-placebo-controlled-phase-3-trial
#18
RANDOMIZED CONTROLLED TRIAL
Jonathan A Ledermann, Andrew C Embleton, Fharat Raja, Timothy J Perren, Gordon C Jayson, Gordon J S Rustin, Stan B Kaye, Hal Hirte, Elizabeth Eisenhauer, Michelle Vaughan, Michael Friedlander, Antonio González-Martín, Daniel Stark, Elizabeth Clark, Laura Farrelly, Ann Marie Swart, Adrian Cook, Richard S Kaplan, Mahesh K B Parmar
BACKGROUND: Angiogenesis is a validated clinical target in advanced epithelial ovarian cancer. Cediranib is an oral antiangiogenic vascular endothelial growth factor receptor 1-3 inhibitor that has shown antitumour activity in recurrent ovarian cancer. We assessed efficacy and safety of cediranib in combination with platinum-based chemotherapy and as continued maintenance treatment in patients with first relapse of platinum-sensitive ovarian cancer. METHODS: In this randomised, three-arm, double-blind, placebo-controlled phase 3 trial, we randomly assigned patients aged 18 years or older with relapsed platinum-sensitive ovarian cancer at 63 centres in Australia, Canada, New Zealand, Spain, and the UK...
March 12, 2016: Lancet
https://www.readbyqxmd.com/read/27020393/accuracy-of-2-clinical-tests-for-ischiofemoral-impingement-in-patients-with-posterior-hip-pain-and-endoscopically-confirmed-diagnosis
#19
Juan Gómez-Hoyos, RobRoy L Martin, Ricardo Schröder, Ian James Palmer, Hal David Martin
PURPOSE: To establish the accuracy of the long-stride walking (LSW) and ischiofemoral impingement (IFI) tests for diagnosing IFI in patients whose primary symptom is posterior hip pain. METHODS: Confirmed IFI cases and cases in which IFI had been ruled out were identified considering imaging, injections, and endoscopic assessment, combined with pain relief and negative IFI-specific tests after treatment. Demographic data, duration of symptoms, pain location, ischiofemoral space, quadratus femoris space, quadratus femoris edema, surgical findings, and visual analog scale score for pain before and after treatment were computed for all patients included in this study...
July 2016: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/27011866/a-mri-study-of-the-lesser-trochanteric-version-and-its-relationship-to-proximal-femoral-osseous-anatomy
#20
Ricardo Gonçalves Schröder, Manoj Reddy, Munif Ahamad Hatem, Juan Gómez-Hoyos, Leon Toye, Anthony Khoury, Hal David Martin
The purpose of this study is to quantify the lesser trochanteric version and determine the angle and the relationship between lesser trochanter and femoral neck version. Investigate the influence of the lesser trochanter version in the width of ischiofemoral space. Two hundred and fifty asymptomatic hips were evaluated with axial magnetic resonance image. The lesser trochanter version was calculated. The difference between the femoral neck version and the lesser trochanter version formed the angle between each structure...
December 2015: Journal of Hip Preservation Surgery
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