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Hal Martin

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https://www.readbyqxmd.com/read/29424783/repeat-testing-of-low-level-hiv-1-rna-assay-performance-and-implementation-in-clinical-trials
#1
Kirsten White, Will Garner, Lilian Wei, Joseph J Eron, Lijie Zhong, Michael D Miller, Hal Martin, Andrew Plummer, Cecilia Tran-Muchowski, Kim Lindstrom, James Porter, David Piontkowsky, Angela Light, Heinz Reiske, Erin Quirk
OBJECTIVE: Assess the performance of HIV-1 RNA repeat testing of stored samples in cases of low-level viremia during clinical trials. DESIGN: Prospective and retrospective analysis of randomized clinical trial samples and reference standards. METHODS: To evaluate assay variability of the Cobas AmpliPrep/Cobas TaqMan HIV-1 Test, v2.0, three separate sources of samples were utilized: the World Health Organization (WHO) HIV reference standard (assayed using 50 independent measurements at six viral loads <200 copies/ml), retrospective analysis of four to six aliquots of plasma samples from four clinical trial participants, and prospective repeat testing of 120 samples from participants in randomized trials with low-level viremia...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29394082/a-genome-wide-association-study-in-hispanics-latinos-identifies-novel-signals-for-lung-function-the-hispanic-community-health-study-study-of-latinos
#2
Kristin M Burkart, Tamar Sofer, Stephanie J London, Ani Manichaikul, Fernando P Hartwig, Qi Yan, María Soler Artigas, Lydiana Avila, Wei Chen, Sonia Davis Thomas, Alejandro A Diaz, Ian P Hall, Bernardo L Horta, Robert C Kaplan, Cathy C Laurie, Ana M Menezes, Jean V Morrison, Elizabeth C Oelsner, Deepa Rastogi, Stephen S Rich, Manuel Soto-Quiros, Adrienne M Stilp, Martin D Tobin, Louise V Wain, Juan C Celedón, R Graham Barr
RATIONALE: Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry. OBJECTIVES: Perform a GWAS of COPD-phenotypes in Hispanic/Latino populations to identify loci not previously detected in European populations. METHODS: GWAS of lung function and COPD in Hispanic/Latino participants from a population-based cohort...
February 2, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29299659/ex-vivo-expanded-nk-cells-from-blood-and-ascites-of-ovarian-cancer-patients-are-cytotoxic-against-autologous-primary-ovarian-cancer-cells
#3
Tina Nham, Sophie M Poznanski, Isabella Y Fan, Mira M Shenouda, Marianne V Chew, Amanda J Lee, Fatemeh Vahedi, Yalda Karimi, Martin Butcher, Dean A Lee, Hal Hirte, Ali A Ashkar
Ovarian cancer (OC) is the leading cause of gynecological cancer-related death in North America. Most ovarian cancer patients (OCPs) experience disease recurrence after first-line surgery and chemotherapy; thus, there is a need for novel second-line treatments to improve the prognosis of OC. Although peripheral blood-derived NK cells are known for their ability to spontaneously lyse tumour cells without prior sensitization, ascites-derived NK cells (ascites-NK cells) isolated from OCPs exhibit inhibitory phenotypes, impaired cytotoxicity and may play a pro-tumourigenic role in cancer progression...
January 3, 2018: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/29261671/tragedy-of-the-commons-in-the-chemostat
#4
Martin Schuster, Eric Foxall, David Finch, Hal Smith, Patrick De Leenheer
We present a proof of principle for the phenomenon of the tragedy of the commons that is at the center of many theories on the evolution of cooperation. Whereas the tragedy is commonly set in a game theoretical context, and attributed to an underlying Prisoner's Dilemma, we take an alternative approach based on basic mechanistic principles of species growth that does not rely on the specification of payoffs which may be difficult to determine in practice. We establish the tragedy in the context of a general chemostat model with two species, the cooperator and the cheater...
2017: PloS One
https://www.readbyqxmd.com/read/29238636/functional-outcome-of-neurologic-controlled-hal-exoskeletal-neurorehabilitation-in-chronic-spinal-cord-injury-a-pilot-with-one-year-treatment-and-variable-treatment-frequency
#5
Oliver Jansen, Thomas A Schildhauer, Renate C Meindl, Martin Tegenthoff, Peter Schwenkreis, Matthias Sczesny-Kaiser, Dennis Grasmücke, Christian Fisahn, Mirko Aach
Study Design: Longitudinal prospective study. Objectives: Whether 1-year HAL-BWSTT of chronic spinal cord injured patients can improve independent ambulated mobility further as a function of training frequency, after an initial 3-month training period. Methods: Eight patients with chronic SCI were enrolled. They initially received full standard physical therapy and neurorehabilitation in the acute/subacute posttrauma phase. During this trial, all patients first underwent a daily (5 per week) HAL-BWSTT for 12 weeks...
December 2017: Global Spine Journal
https://www.readbyqxmd.com/read/29234567/nerve-entrapment-in-the-hip-region-current-concepts-review
#6
RobRoy Martin, Hal David Martin, Benjamin R Kivlan
The purpose of this clinical commentary is to review the anatomy, etiology, evaluation, and treatment techniques for nerve entrapments of the hip region. Nerve entrapment can occur around musculotendinous, osseous, and ligamentous structures because of the potential for increased strain and compression on the peripheral nerve at those sites. The sequela of localized trauma may also result in nerve entrapment if normal nerve gliding is prevented. Nerve entrapment can be difficult to diagnose because patient complaints may be similar to and coexist with other musculoskeletal conditions in the hip and pelvic region...
December 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29203381/accuracy-of-3-clinical-tests-to-diagnose-proximal-hamstrings-tears-with-and-without-sciatic-nerve-involvement-in-patients-with-posterior-hip-pain
#7
RobRoy L Martin, Ricardo Gonçalves Schröder, Juan Gomez-Hoyos, Anthony N Khoury, Ian James Palmer, Ryan P McGovern, Hal David Martin
PURPOSE: To determine the diagnostic accuracy of the active hamstring test at 30° (A-30) and 90° (A-90) of knee flexion, the long stride heel strike (LSHS) test, and combination of the 3 tests for individuals with hamstring tendon tears, with and without sciatic nerve involvement. METHODS: A retrospective review of 564 consecutive clinical records identified 42 subjects with a mean age of 50.31 ± 15 years who underwent a standard physical examination prior to magnetic resonance imaging (MRI) evaluation and diagnostic injection for posterior hip...
December 1, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29198354/editorial-commentary-pioneering-the-gluteal-interval-understanding-and-treating-undersurface-and-full-thickness-gluteus-medius-tears-of-the-hip
#8
EDITORIAL
Hal David Martin
Lateral-based hip disease is severely impairing for many patients. Treatment decision making requires a thorough understanding of the biomechanical and clinical interpretation of the physical examination. The outcomes of these under-recognized pathologies are explained with success. A recent study has described the diagnostic and surgical treatment outcomes of this impairing condition of partial and full-thickness gluteus medius tears.
December 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29145543/association-of-ipilimumab-with-safety-and-antitumor-activity-in-women-with-metastatic-or-recurrent-human-papillomavirus-related-cervical-carcinoma
#9
Stephanie Lheureux, Marcus O Butler, Blaise Clarke, Mihaela C Cristea, Lainie P Martin, Katia Tonkin, Gini F Fleming, Anna V Tinker, Hal W Hirte, Daliah Tsoref, Helen Mackay, Neesha C Dhani, Prafull Ghatage, Johanne Weberpals, Stephen Welch, Nhu-An Pham, Vinicius Motta, Valentin Sotov, Lisa Wang, Katherine Karakasis, Smitha Udagani, Suzanne Kamel-Reid, Howard Z Streicher, Patricia Shaw, Amit M Oza
Importance: Based on evidence of human papillomavirus (HPV)-induced immune evasion, immunotherapy may be an attractive strategy in cervical cancer. Ipilimumab is a fully humanized monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4 (CTLA-4), which acts to downregulate the T-cell immune response. Objective: To assess the safety and antitumor activity of ipilimumab in recurrent cervical cancer. Design, Setting, and Participants: A multicenter trial was designed for patients with metastatic cervical cancer (squamous cell carcinoma or adenocarcinoma) with measurable disease and progression after at least 1 line of platinum chemotherapy...
November 16, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/29113931/neurobiological-mechanisms-of-chemotherapy-induced-cognitive-impairment-in-a-transgenic-model-of-breast-cancer
#10
Gordon Winocur, Hal Berman, Mary Nguyen, Malcolm A Binns, Mark Henkelman, Matthijs van Eede, Micheline Piquette-Miller, Melanie J Sekeres, J Martin Wojtowicz, Johnson Yu, Haibo Zhang, Ian F Tannock
Animal studies have reinforced clinical reports of cognitive impairment in cancer survivors following chemotherapy but, until now, all pre-clinical research in this area has been conducted on normal rodents. The present study investigated the effects of chemotherapy on cognition and underlying biological mechanisms in the FVB/N-Tg (MMTV-neu) 202 Mul/J mouse, a well-characterized transgenic model of breast cancer that has similarities to the tumorigenesis which occurs in humans. Tumor-bearing and control mice received three weekly injections of a combination of methotrexate + 5-fluorouracil, or an equal volume of saline...
November 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/29081392/hybrid-assistive-limb-exoskeleton-hal%C3%A2-in-the-rehabilitation-of-chronic-sci-proof-of-concept-the-results-of-21-patients
#11
Oliver Jansen, Dennis Grasmuecke, Renate C Meindl, Martin Tegenthoff, Peter Schwenkreis, Matthias Sczesny-Kaiser, Martin Wessling, Thomas A Schildhauer, Christian Fisahn, Mirko Aach
INTRODUCTION: The use of mobile exoskeletons is becoming more and more common in the field of spinal cord injury rehabilitation. The hybrid assistive limb exoskeleton (HAL) provides a tailored support depending on the patient's voluntary drive. MATERIALS AND METHODS: After a pilot study which included 8 chronic SCI patients (2014), this study of 21 chronic SCI patients serves as a proof of concept. It was conducted to provide further evidence regarding the efficacy of exoskeletal-based rehabilitation...
October 25, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28867497/bictegravir-emtricitabine-and-tenofovir-alafenamide-versus-dolutegravir-abacavir-and-lamivudine-for-initial-treatment-of-hiv-1-infection-gs-us-380-1489-a-double-blind-multicentre-phase-3-randomised-controlled-non-inferiority-trial
#12
Joel Gallant, Adriano Lazzarin, Anthony Mills, Chloe Orkin, Daniel Podzamczer, Pablo Tebas, Pierre-Marie Girard, Indira Brar, Eric S Daar, David Wohl, Jürgen Rockstroh, Xuelian Wei, Joseph Custodio, Kirsten White, Hal Martin, Andrew Cheng, Erin Quirk
BACKGROUND: Integrase strand transfer inhibitors (INSTIs) are recommended components of initial antiretroviral therapy with two nucleoside reverse transcriptase inhibitors. Bictegravir is a novel, potent INSTI with a high in-vitro barrier to resistance and low potential as a perpetrator or victim of clinically relevant drug-drug interactions. We aimed to assess the efficacy and safety of bictegravir coformulated with emtricitabine and tenofovir alafenamide as a fixed-dose combination versus coformulated dolutegravir, abacavir, and lamivudine...
November 4, 2017: Lancet
https://www.readbyqxmd.com/read/28866346/surgical-management-of-deep-gluteal-syndrome-causing-sciatic-nerve-entrapment-a-systematic-review
#13
REVIEW
Jeffrey Kay, Darren de Sa, Laura Morrison, Emily Fejtek, Nicole Simunovic, Hal D Martin, Olufemi R Ayeni
PURPOSE: To assess the causes, surgical indications, patient-reported clinical outcomes, and complications in patients with deep gluteal syndrome causing sciatic nerve entrapment. METHODS: Three databases (PubMed, Ovid [MEDLINE], and Embase) were searched by 2 reviewers independently from database inception until September 7, 2016. The inclusion criteria were studies reporting on both arthroscopic and open surgery and those with Level I to IV evidence. Systematic reviews, conference abstracts, book chapters, and technical reports with no outcome data were excluded...
December 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28790030/notch-shapes-the-innate-immunophenotype-in-breast-cancer
#14
Qiang Shen, Brenda Cohen, Weiyue Zheng, Ramtin Rahbar, Bernard Martin, Kiichi Murakami, Sara Lamorte, Patrycja Thompson, Hal Berman, Juan Carlos Zúñiga-Pflücker, Pamela S Ohashi, Michael Reedijk
Notch activation, which is associated with basal-like breast cancer (BLBC), normally directs tissue patterning, suggesting that it may shape the tumor microenvironment. Here, we show that Notch in tumor cells regulates the expression of two powerful proinflammatory cytokines, IL1β and CCL2, and the recruitment of tumor-associated macrophages (TAM). Notch also regulates TGFβ-mediated activation of tumor cells by TAMs, closing a Notch-dependent paracrine signaling loop between these two cell types. We use a mouse model in which Notch can be regulated in spontaneous mammary carcinoma to confirm that IL1β and CCL2 production, and macrophage recruitment are Notch-dependent...
August 8, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/28722720/a-guiding-map-for-inflammation
#15
Mihai G Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y Donath, Evangelos J Giamarellos-Bourboulis, Douglas Golenbock, Mark S Gresnigt, Michael T Heneka, Hal M Hoffman, Richard Hotchkiss, Leo A B Joosten, Daniel L Kastner, Martin Korte, Eicke Latz, Peter Libby, Thomas Mandrup-Poulsen, Alberto Mantovani, Kingston H G Mills, Kristen L Nowak, Luke A O'Neill, Peter Pickkers, Tom van der Poll, Paul M Ridker, Joost Schalkwijk, David A Schwartz, Britta Siegmund, Clifford J Steer, Herbert Tilg, Jos W M van der Meer, Frank L van de Veerdonk, Charles A Dinarello
Biologists, physicians and immunologists have contributed to the understanding of the cellular participants and biological pathways involved in inflammation. Here, we provide a general guide to the cellular and humoral contributors to inflammation as well as to the pathways that characterize inflammation in specific organs and tissues.
July 19, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28630740/the-effects-of-hip-abduction-on-sciatic-nerve-biomechanics-during-terminal-hip-flexion
#16
Hal David Martin, Anthony N Khoury, Ricardo Schroder, Juan Gomez-Hoyos, Samrat Yeramaneni, Manoj Reddy, Ian James Palmer
Terminal hip flexion contributes to increased strain in peripheral nerves at the level of the hip joint. The effects of hip abduction and femoral version on sciatic nerve biomechanics are not well understood. A decrease in sciatic nerve strain will be observed during terminal hip flexion and hip abduction, independent of femoral version. Six un-embalmed human cadavers were utilized. Three Differential Variable Reluctance Transducers (DVRTs) sensors were placed on the sciatic nerve while the leg was flexed to 70° with a combination of - 10°, 0°, 20° and 40° adduction/abduction...
July 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28630728/parameters-for-assessment-of-the-inferior-acetabulum-morphology-in-300-adult-hips
#17
Munif A Hatem, Luiz A M da Cunha, João C M Abdo, Hal David Martin
The inferior acetabulum (IA) has been studied as a stabilizer of the hip in flexed positions with potential implications in femoroacetabular impingement and hip instability. However, there is a paucity of studies considering the normal morphology and parameters for assessment of the IA. The purpose of this study was to define parameters to assess the IA morphology and their normal range. Specifically, the objectives were to assess: (i) the width of the anterior horn (AH) and posterior horn (PH) of the acetabulum; (ii) the inclination of the articular surface of the AH angle (AHA) and PH angle (PHA) in the axial plane; (iii) the anterior opening angle of the IA and differences between genders...
January 2017: Journal of Hip Preservation Surgery
https://www.readbyqxmd.com/read/28463613/against-the-odds-what-to-expect-in-rehabilitation-of-chronic-spinal-cord-injury-with-a-neurologically-controlled-hybrid-assistive-limb-exoskeleton-a-subgroup-analysis-of-55-patients-according-to-age-and-lesion-level
#18
Dennis Grasmücke, Amrei Zieriacks, Oliver Jansen, Christian Fisahn, Matthias Sczesny-Kaiser, Martin Wessling, Renate C Meindl, Thomas A Schildhauer, Mirko Aach
Objective Age and lesion level are believed to represent outcome predictors in rehabilitation of patients with chronic spinal cord injury (SCI). The Hybrid Assistive Limb (HAL) exoskeleton enables patients to perform a voluntary controlled gait pattern via an electromyography-triggered neuromuscular feedback system, and has been introduced as a temporary gait training tool in patients with SCI. The aim of this prospective pre- and postintervention study was to examine functional outcomes as a function of age and lesion level in patients with chronic incomplete SCI (iSCI) or chronic complete SCI (cSCI) with zones of partial preservation (ZPP) by using the HAL as a temporary training tool...
May 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28453881/effect-of-an-acute-exercise-bout-on-immediate-post-exercise-irisin-concentration-in-adults-a-meta-analysis
#19
REVIEW
J Fox, B V Rioux, E D B Goulet, N M Johanssen, D L Swift, D R Bouchard, H Loewen, M Sénéchal
Irisin is a recently discovered myokine that increases adipocyte metabolism, induces further "browning" of white adipose tissue, and enhances glucose metabolism. No study has ever determined how an acute bout of exercise impacts immediate post-exercise irisin concentration using a meta-analytic approach. The purpose of this study is to determine the impact of an acute bout of exercise on the magnitude of post-exercise irisin concentration in adults using meta-analytic procedures. Searches were performed on PubMed, EMBASE, CINAHL, PEDro, SCOPUS, and SPORTDiscus databases...
April 28, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28390662/influence-of-aging-on-microvascular-supply-of-the-gluteus-medius-tendon-a-cadaveric-and-histologic-study
#20
William H Márquez-Arabia, Juan Gómez-Hoyos, Marcela Gómez, Isabel Flórez, Jaime A Gallo, Francisco Monsalve, Luis F Arias, Hal D Martin
PURPOSE: The purpose of this cadaveric study was to assess the relation between age and microvascular supply of 3 areas of the gluteus medius tendon using a previously validated CD31 immunohistochemistry staining technique. METHODS: Twenty-four fresh-frozen gluteus medius specimens were obtained through a posterolateral approach to the hip. Specimens aged 18 years or older, of either sex, and of any race were considered for this study. The average age of donors was 47...
April 5, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
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