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https://www.readbyqxmd.com/read/29149865/cytoreductive-surgery-and-hyperthermic-intra-operative-peritoneal-chemotherapy-with-cisplatin-for-gastric-peritoneal-carcinomatosis-monocentric-phase-2-nonrandomized-prospective-clinical-trial
#1
Baki Topal, Karel Demey, Halit Topal, Joris Jaekers, Eric Van Cutsem, Vincent Vandecaveye, Xavier Sagaert, Hans Prenen
BACKGROUND: Cytoreductive surgery (CRS) plus hyperthermic intra-operative peritoneal chemotherapy (HIPC) for gastric peritoneal carcinomatosis (PC) is controversial, and selection criteria for this treatment modality are lacking. METHODS: Thirty-two patients (F/M ratio 12/20; median (range) age 58 (32-75) years) underwent CRS + HIPC with cisplatin for PC from gastric adenocarcinoma in 2010-2014. This monocentric phase-2 nonrandomized prospective study with a power of 90% aimed to improve the 1-year overall survival (OS) rate with 40% (historical reference of 52% to 72%)...
November 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29143892/update-in-the-therapy-of-advanced-neuroendocrine-tumors
#2
REVIEW
Inbal Uri, Shani Avniel-Polak, David J Gross, Simona Grozinsky-Glasberg
Neuroendocrine tumors (NETs) are rare neoplasms, with an estimated annual incidence of ~ 6.9/100,000. NETs arise throughout the body from cells of the diffuse endocrine system. More than half originate from endocrine cells of the gastrointestinal tract and the pancreas, thus being referred to as gastroenteropancreatic NETs (GEP-NETs). The only treatment that offers a cure is surgery; however, most patients are diagnosed with metastatic disease, and curative surgery is usually not an option. These patients can be offered long-term systemic treatment, for both symptomatic relief and tumor growth suppression...
November 16, 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/29143144/carcinosarcoma-of-the-ovary-compared-to-ovarian-high-grade-serous-carcinoma-impact-of-optimal-cytoreduction-and-standard-adjuvant-treatment
#3
Ibrahim Yalcin, Mehmet Mutlu Meydanli, Ahmet Taner Turan, Salih Taskin, Mustafa Erkan Sari, Tayfun Gungor, Ozgur Akbayir, Ali Ayhan
OBJECTIVE: The purpose of this retrospective study was to compare the prognoses of women with ovarian carcinosarcoma (OCS) who had optimal cytoreductive surgery followed by platinum plus taxane combination chemotherapy to those of women with ovarian high-grade serous carcinoma (HGSC) treated in the same manner. METHODS: A multicenter, retrospective department database review was performed to identify patients with OCS at eight gynecologic oncology centers in Turkey...
November 16, 2017: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29138949/multiple-high-grade-gliomas-epidemiology-management-and-outcome-a-systematic-review-and-meta-analysis
#4
REVIEW
Davide Tiziano Di Carlo, Federico Cagnazzo, Nicola Benedetto, Riccardo Morganti, Paolo Perrini
Multiple high-grade gliomas (M-HGGs) are well--separated tumors, differentiated as multifocal (MF) and multicentric (MC) by their MRI features. The authors performed a systematic review and meta-analysis of literature examining epidemiology, clinical and radiological characteristics, management, and the overall survival from M-HGGs. According to PRISMA guidelines, a comprehensive review of studies published between January 1990 and January 2017 was carried out. The authors identified studies that examined the prevalence rate, clinical and radiological characteristics, treatment, and overall survival from M-HGGs in patients with HGG...
November 14, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/29137079/treatment-of-hypermyoglobinemia-after-crs-hipec-for-patients-with-peritoneal-carcinomatosis-a-retrospective-comparative-study
#5
Gang Liu, Zhong-He Ji, Yang Yu, Xin-Bao Li, Yan-Bin Zhang, Kai-Wen Peng, Yan Li
This retrospective comparative study aims to explore the time courses of serum myoglobin (Mb) changes, and summarize our experience in treating patients with hypermyoglobinemia after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC).This study covered 60 patients with peritoneal carcinomatosis treated with CRS + HIPEC as the study group, and another 25 cancer patients treated with conventional extensive surgery without HIPEC as the control group from February to October 2016...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29136604/extragenital-malignant-mixed-mesodermal-tumor-a-case-report
#6
Mauro Del Papa, Gabriele D'Amata, Fulvio Manzi, Luca Musmeci, Marco Crovaro, Carlo Buonocore, Gaetano Florio, Andrea Giannetti
INTRODUCTION: Primary malignant mixed mesodermal tumor (MMMt, also called malignant mixed Mullerian tumor and designated in the WHO classification of female genital tract neoplasms as carcinosarcoma) is an infrequent tumor that develops usually in the uterus and more rarely in the ovary. Extragenital tumor, including primary peritoneal MMMt, is an extremely rare and aggressive neoplasm with only few case reported in the literature. PRESENTATION OF CASE: We report a case of a 70-year's old female who presented with nausea and abdominal discomfort for 6 months...
November 9, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29135665/cryoablation-of-bone-metastases-from-renal-cell-carcinoma-for-local-tumor-control
#7
Carly S Gardner, Joe E Ensor, Kamran Ahrar, Steven Y Huang, Sharjeel H Sabir, Nizar M Tannir, Valerae O Lewis, Alda L Tam
BACKGROUND: Patients with bone metastases from renal cell carcinoma often are not surgical candidates and have a poor prognosis. There are limited data on the use of cryoablation as a locoregional therapy for bone metastases. Our objective was to assess the local tumor-control rate following cryoablation of bone metastases in the setting of renal cell carcinoma. METHODS: We retrospectively reviewed the medical records of patients with metastatic renal cell carcinoma who underwent cryoablation for bone metastases between 2007 and 2014...
November 15, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29135123/hepatobiliary-and-pancreatic-procedures-during-cytoreductive-surgery-and-hipec
#8
Ioannis Kyriazanos, Nikolaos Kopanakis, Vasileios Kalles, Alexios Tzivanakis, Georgios Nikolaou, Elias Efstathiou, John Spiliotis
PURPOSE: The combination of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has been used as locoregional treatment in selected patients with peritoneal malignancy. The purpose of this study was to report on the outcomes of patients undergoing hepatobiliary and pancreatic procedures during CRS and HIPEC. METHODS: A prospectively maintained database was used to identify patients that underwent hepatobilliary and/or pancreatic procedures during CRS and HIPEC...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29135095/does-upfront-therapy-with-cytoreductive-surgery-and-hipec-confer-a-survival-benefit-in-patients-with-synchronous-gastric-peritoneal-carcinomatosis-when-compared-with-patients-with-metachronous-gastric-peritoneal-carcinomatosis
#9
Nikolaos Kopanakis, Elias Efstathiou, Dimitrios Sarris, John Spiliotis
Gastric cancer (GC) remains the second leading cause of cancer death worldwide, accounting for 8% of the total cases and 10% of total deaths in 2008. Surgery remains the curative treatment option for GC and the main reason for treatment failure is peritoneal recurrence which, according to the literature, occurs in 40-60% of the cases, despite extensive surgery including D2 lymph node dissection. The hyperthermic intraperitoneal chemotherapy (HIPEC) technique is increasingly used in the treatment of primary and digestive peritoneal carcinomatosis (PC), in association with cytoreductive surgery (CRS)...
September 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29134372/systematic-review-of-cytoreductive-surgery-and-bevacizumab-containing-chemotherapy-in-advanced-ovarian-cancer-focus-on-safety
#10
REVIEW
Marco Petrillo, Camilla Nero, Vittoria Carbone, Matteo Bruno, Giovanni Scambia, Anna Fagotti
BACKGROUND: Initial experiences reported increased surgical morbidities in patients receiving cytoreductive surgery for colorectal cancer after bevacizumab-containing chemotherapy; however, more recent literature suggests a favorable toxicity profile in patients with advanced ovarian cancer (AOC). With the aim of providing a more objective point of view on this controversial issue, we present here a systematic literature review. METHODS: Systematic revision of the available literature was conducted using the PubMed, MEDLINE, and EMBASE electronic databases...
November 13, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29132550/cytoreductive-cryosurgery-in-patients-with-bone-metastatic-prostate-cancer-a-retrospective-analysis
#11
Ming-Xiong Sheng, Ling-Ling Wan, Chang-Ming Liu, Chun-Xiao Liu, Shu-Shang Chen
The current study is a retrospective analysis of 49 patients with bone metastatic prostate cancer: 26 receiving androgen deprivation therapy (ADT) alone versus 23 receiving cytoreductive cryosurgery of the primary tumor plus ADT treatment. Progression-free survival (PFS) was the primary outcome variable, and Cox proportional hazards regression analysis was used to identify predictors for PFS. The baseline characteristics were generally comparable between the 2 groups. Median follow-up time was 41 months (range 24-56) and 37 months (range 19-53) in ADT alone group and cryosurgery groups, respectively...
December 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29132061/synchronous-peritoneal-metastases-of-small-bowel-adenocarcinoma-insights-into-an-underexposed-clinical-phenomenon
#12
Laura M Legué, Geert A Simkens, Geert-Jan M Creemers, Valery E P P Lemmens, Ignace H J T de Hingh
BACKGROUND: The aim of this population-based study was to provide insight into the incidence, risk factors and treatment-related survival of patients with peritoneal metastases (PM) of small bowel adenocarcinoma (SBA). METHODS: Data from the Netherlands Cancer Registry were used. All patients diagnosed with SBA between 2005 and 2014 were included. The influence of patient and tumour characteristics on the odds of developing PM was analysed. Subsequently, for all further analyses, patients without synchronous PM of SBA were excluded...
November 10, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29129391/centralization-of-ovarian-cancer-in-the-netherlands-hospital-of-diagnosis-no-longer-determines-patients-probability-of-undergoing-surgery
#13
Maite Timmermans, Melinda S Schuurman, Vincent K Y Ho, Leon F Massuger, Hans W Nijman, Toon van Gorp, Gabe S Sonke, Roy F P M Kruitwagen, Maaike A van der Aa
OBJECTIVE: Surgical care for advanced stage epithelial ovarian cancer (EOC) patients has been centralized in the Netherlands since 2012. We evaluated whether the likelihood for patients to undergo surgery depends on the hospital of initial diagnosis before and after centralization of surgical care. METHODS: Patients with EOC FIGO stage IIB-IV, diagnosed in the Netherlands between 2000 and 2015, were identified from the Netherlands Cancer Registry. Multilevel multivariate logistic regression was used to study the association between hospital of diagnosis and patients' likelihood of undergoing surgery in subsequent time periods...
November 9, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29128421/trends-in-usage-of-cytoreductive-partial-nephrectomy-and-effect-on-overall-survival-in-patients-with-metastatic-renal-cell-carcinoma
#14
Andrew T Lenis, Amirali H Salmasi, Nicholas M Donin, Izak Faiena, David C Johnson, Alexandra Drakaki, Kiran Gollapudi, Jeremy Blumberg, Arie S Belldegrun, Allan J Pantuck, Karim Chamie
PURPOSE: Cytoreductive radical nephrectomy (cRN) improves survival in select patients with metastatic renal cell carcinoma (mRCC). It is unclear, however, whether cytoreductive partial nephrectomy (cPN) compromises oncologic efficacy. We evaluated trends in utilization of cPN and compared overall survival (OS) in patients who underwent cRN or cPN for mRCC. MATERIALS AND METHODS: We queried the National Cancer Database from 2006 to 2013 and identified patients who underwent cPN and cRN for mRCC...
November 8, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29128106/who-are-the-long-term-survivors-of-high-grade-serous-ovarian-cancer
#15
REVIEW
Claire Hoppenot, Mark A Eckert, Samantha M Tienda, Ernst Lengyel
Although the median survival for epithelial ovarian cancer (EOC) is <5years, approximately 15% of patients will survive for >10years. A better understanding of these exceptional responders could reveal opportunities to improve the dismal prognosis of most EOC patients. In this review, we examine the clinical and genomic features that have been associated with long-term survival, which is generally defined as survival of >7-10years after initial diagnosis. Clinical features influencing long-term survival have been best reported in large retrospective population-based studies...
November 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29128105/factors-associated-with-delivery-of-neoadjuvant-chemotherapy-in-women-with-advanced-stage-ovarian-cancer
#16
Emily Hinchcliff, Alexander Melamed, Amy Bregar, Elisabeth Diver, Joel Clemmer, Marcela Del Carmen, John O Schorge, J Alejandro Rauh-Hain
PURPOSE: To identify clinical and non-clinical factors associated with utilization of primary cytoreductive surgery (PCS) or neoadjuvant chemotherapy (NACT) in women with advanced stage epithelial ovarian cancer (EOC). METHODS: Using the National Cancer Database, we identified women with stage IIIC and IV EOC diagnosed from 2012 to 2014. The primary outcome was receipt of NACT, defined in the primary analysis as utilization of chemotherapy as the first cancer-directed therapy, irrespective of whether interval surgery was performed...
November 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29122377/the-role-of-surgery-in-metastatic-bladder-cancer-a-systematic-review
#17
REVIEW
Mohammad Abufaraj, Guido Dalbagni, Siamak Daneshmand, Simon Horenblas, Ashish M Kamat, Ryu Kanzaki, Alexandre R Zlotta, Shahrokh F Shariat
CONTEXT: The role of surgery in metastatic bladder cancer (BCa) is unclear. OBJECTIVE: In this collaborative review article, we reviewed the contemporary literature on the surgical management of metastatic BCa and factors associated with outcomes to support the development of clinical guidelines as well as informed clinical decision-making. EVIDENCE ACQUISITION: A systematic search of English language literature using PubMed-Medline and Scopus from 1999 to 2016 was performed...
November 6, 2017: European Urology
https://www.readbyqxmd.com/read/29121779/image-guided-surgery-in-gynecologic-oncology
#18
Henri Azaïs, Geoffroy Canlorbe, Yohan Kerbage, Anne Grabarz, Pierre Collinet, Serge Mordon
Image-guided surgery is a relevant way to reduce surgical morbidity and maximize cytoreductive surgery approach especially in ovarian cancer. Sentinel lymph node detection is a promising approach to avoid radical lymph node dissection and is slightly becoming standard in daily practice in endometrial and cervical cancer surgery even if it needs to be evaluated more precisely. Regarding carcinomatosis of ovarian origin, detection and treatment of microscopic disease could be appropriate to avoid local recurrences...
November 10, 2017: Future Oncology
https://www.readbyqxmd.com/read/29120491/clinical-studies-in-crs-and-hipec-trials-tribulations-and-future-directions-a-systematic-review
#19
William F Morano, Marian Khalili, Dennis S Chi, Wilbur B Bowne, Jesus Esquivel
BACKGROUND: The field of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has suffered from a lack of clinical trials to validate its expanding use. OBJECTIVE: To evaluate published and ongoing clinical trials seeking to better define role of CRS/HIPEC in the treatment of peritoneal surface malignancies. METHODS: Systematic review by PubMed search was performed using terms "Clinical trial," "intraperitoneal chemotherapy," and "HIPEC...
November 9, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29120401/does-locoregional-chemotherapy-still-matter-in-the-treatment-of-advanced-pelvic-melanoma
#20
Stefano Guadagni, Giammaria Fiorentini, Marco Clementi, Giancarlo Palumbo, Paola Palumbo, Alessandro Chiominto, Stefano Baldoni, Francesco Masedu, Marco Valenti, Ambra Di Tommaso, Bianca Fabi, Camillo Aliberti, Donatella Sarti, Veronica Guadagni, Cristina Pellegrini
Pelvic Melanoma relapse occurs in 15% of patients with loco regional metastases, and 25% of cases do not respond to new target-therapy and/or immunotherapy. Melphalan hypoxic pelvic perfusion may, therefore, be an option for these non-responsive patients. Overall median survival time (MST), stratified for variables, including BRAF V600E mutation and eligibility for treatments with new immunotherapy drugs, was retrospectively assessed in 41 patients with pelvic melanoma loco regional metastases. They had received a total of 175 treatments with Melphalan hypoxic perfusion and cytoreductive excision...
November 9, 2017: International Journal of Molecular Sciences
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