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https://www.readbyqxmd.com/read/29332078/magnetic-resonance-guided-high-intensity-focused-ultrasound-for-treating-movement-disorders
#1
Young Goo Kim, Eun Jung Kweon, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang
Transcranial magnetic resonance-guided focused ultrasound (MRgFUS) surgery has recently gained favor as a novel, noninvasive alternative to conventional neurosurgery. In contrast to traditional ablative interventions, transcranial MRgFUS surgery is entirely imaging-guided and uses continuous temperature measurements at the target and surrounding tissue taken in real-time. Unlike Gamma Knife radiosurgery, MRgFUS surgery can make a lesion immediately and does not use ionizing radiation. Moreover, since no metallic device is implanted, MR imaging-based diagnosis is not restricted throughout life...
2018: Progress in Neurological Surgery
https://www.readbyqxmd.com/read/29331361/uterine-artery-embolization-an-analysis-of-online-patient-information-quality-and-readability-with-historical-comparison
#2
Timothy E Murray, Tayyaub Mansoor, Dermot J Bowden, Damien C O'Neill, Michael J Lee
RATIONALE AND OBJECTIVES: Investigators aimed to assess online information describing uterine artery embolization (UAE) to examine the quality and readability of websites patients are accessing. MATERIALS AND METHODS: A list of applicable, commonly used searchable terms was generated, including "Uterine Artery Embolization," "Fibroid Embolization," "Uterine Fibroid Embolization," and "Uterine Artery Embolisation." Each possible term was assessed across the five most-used English language search engines to determine the most commonly used term...
January 10, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29328939/outcome-of-patients-with-uterine-fibroids-after-3-month-ulipristal-acetate-therapy
#3
Jean-Luc Brun, José Rajaonarison, Alizée Froeliger, Anne-Coline Monseau-Thiburce, Rado Randriamboavonjy, Andrej Vogler
OBJECTIVES: To determine the proportion and the characteristics of patients who did or did not respond after 3 months of ulipristal acetate (UPA) therapy. STUDY DESIGN: In this retrospective cohort study conducted in the University Hospital of Bordeaux (France) and University Medical Center Ljubljana (Slovenia), symptomatic non-menopausal patients with fibroids that qualified for surgery were pretreated by 3 months of oral UPA 5 mg/day. Clinical success was defined by normalization of the bleeding score, and/or regression of pelvic pain, and/or abdominal distension...
December 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29320956/transvaginal-elastosonography-as-an-imaging-technique-for-diagnosing-adenomyosis
#4
Xishi Liu, Ding Ding, Yunyun Ren, Sun-Wei Guo
To test the hypothesis that the lesional stiffness as measured by transvaginal elastosonography (TVESG) correlates with the extent of fibrosis in adenomyotic (AM) lesions, and thus TVESG can be used to diagnose AM, we conducted 2 studies. The first evaluated the relationship, if any, between lesional stiffness and lesional histology in 35 women with histologically confirmed AM in comparison with tissue stiffness in 11 control myometrial (CM) and 8 uterine fibroids (UFs) tissue samples. The second validated the relationship between lesional stiffness and the severity of dysmenorrhea and the amount of menses in AM patients by recruiting 112 patients diagnosed with AM, 67 with UF, and 130 controls...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29320955/therapeutic-roles-of-statins-in-gynecology-and-obstetrics-the-current-evidence
#5
Burak Zeybek, Maged Costantine, Gokhan S Kilic, Mostafa A Borahay
INTRODUCTION: Statins are a class of drugs, which act by inhibiting the rate-limiting enzyme of cholesterol biosynthesis (3-hydroxy-3-methyl-glutaryl-CoA reductase). The inhibition of mevalonate synthesis leads to subsequent inhibition of downstream products of this pathway, which explains the pleiotropic effects of these agents in addition to their well-known lipid-lowering effects. Accumulating evidence suggests that statins might be beneficial in various obstetric and gynecologic conditions...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29317071/recently-discovered-interstitial-cells-telocytes-as-players-in-the-pathogenesis-of-uterine-leiomyomas
#6
Ivan Varga, Martin Klein, Ladislav Urban, Ludovit Danihel, Stefan Polak, Ludovit Danihel
Uterine telocytes are interstitial cells characterized by a very long cytoplasmic prolongations, which form a 3D network, functionally integrating a wide variety of different cells. Leiomyomas (uterine fibroids) are benign tumors, which pose a huge threat concerning various health problems in women affected by this condition. The exact cause of leiomyomas development is, however, still largely unknown. Therefore, in an attempt to clarify their etiology, we performed an immunohistochemical characterization of telocytes in leiomyomas as well as in normal myometrium...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29307983/huge-9-kg-broad-ligament-fibroid-mimicking-sarcoma-of-uterus-a-case-report-and-review-of-literature
#7
Rajshree Dayanand Katke
Fibroids are most common benign tumors of the uterus, mostly situated in the body of the uterus. Rarely, they arise from extrauterine sites with broad ligament fibroids being uncommon. We present a case of a 47-year-old female, multipara who presented in outpatient department in CAMA hospital with a history of sudden development of dysuria 10 days back. Intraoperatively, uterus was pushed to side and large broad ligament fibroid of 25 cm × 20 cm × 20 cm seen arising from right-sided broad ligament. The fibroid was densely adherent to bowel and bladder...
October 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29307982/current-practices-for-treatment-of-uterine-fibroids
#8
Shalini Singh, Tanmay Thulkar, Monisha Pawanarkar, Jyoti Thulkar
The treatment of uterine fibroids depends on symptoms of patients, size of the fibroid, desire for future pregnancy, and preference of the treating gynecologist. The present study was undertaken to compare treatment preferences in women desirous and nondesirous of pregnancy by an experienced gynecologist in symptomatic uterine fibroids. Newer medical or minimally invasive treatment modalities are increasingly being used for the treatment of fibroids. However, conventional surgical treatment such as myomectomy and hysterectomy are still preferred by gynecologists...
October 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29303934/calcification-a-disregarded-or-ignored-issue-in-the-gynecologic-tumor-microenvironments
#9
Jirui Wen, Yali Miao, Shichao Wang, Ruijie Tong, Zhiwei Zhao, Jiang Wu
Although calcification in the gynecologic tumor microenvironments is a common phenomenon, doctors and researchers still disregard or ignore the issue. In fact, this change in the gynecologic tumor microenvironments is clinically significant and a number of studies have reported an association between calcification and gynecological tumor progression. In ovarian cancer, calcification is predominantly psammomatous and largely occurs in serous papillary ovarian tumors. In addition, calcification in ovarian cancer correlated with lower histologic grade and may indicate a poorer survival rate...
January 4, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29301450/effects-of-a-microbubble-ultrasound-contrast-agent-on-high-intensity-focused-ultrasound-for-uterine-fibroids-a-randomised-controlled-trial
#10
Yan Chen, Jing Jiang, Yuhua Zeng, Xiaobing Tian, Miao Zhang, Hong Wu, Honggui Zhou
OBJECTIVE: To investigate the effects of a microbubble ultrasound contrast agent on high-intensity focused ultrasound (HIFU) treatment of uterine fibroids. METHODS: A total of 120 patients with solitary uterine fibroid were randomly assigned into Groups A, B, C and D. Patients in Groups A and B received 1.5 ml of SonoVue, Groups C and D received 1.5 ml of saline before HIFU ablation. HIFU sonication started at 6 min after administration of SonoVue or saline in Groups A and C, whereas it started at 10 min in Groups B and D...
January 4, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29299762/risk-reduction-surgery-rrs-for-tubo-ovarian-cancer-in-an-irish-gynaecological-practice-an-analysis-of-indications-and-outcomes
#11
Claire Thompson, Ciara McCormick, Waseem Kamran, Ciaran O'Riain, Lucy Norris, David Gallagher, Noreen Gleeson
BACKGROUND: High-grade serous carcinoma (HGSC) is the most common tubo-ovarian cancer. The fallopian tube harbours the precursor lesion: serous tubal intraepithelial carcinoma (STIC). Bilateral salpingo-oophorectomy is an effective risk-reducing surgical (RRS) strategy for breast cancer susceptibility gene mutation carriers (BRCAm). The value of RRS in those without defined genetic risk is unknown but these women represent a substantial cohort in prophylactic surgical practice. METHODS: This is a retrospective review of RRS at an Irish university teaching hospital...
January 3, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29288921/outcome-of-magnetic-resonance-guided-focused-ultrasound-surgery-mrgfus-for-figo-class-1-fibroids
#12
Roy Mashiach, Yael Inbar, Jaron Rabinovici, Aya Mohr Sasson, Aviva Alagem-Mizrachi, Ronit Machtinger
OBJECTIVE: Intracavitary uterine fibroids and fibroids that distort the uterine cavity are associated with excessive vaginal bleeding and infertility. While intracavitary fibroids smaller than 4 cm are usually treated safely by operative hysteroscopy, larger fibroids may require multiple surgeries or more extensive surgery with possible damage to the integrity of the uterine wall. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is a noninvasive approach for treating uterine fibroids, mainly the intramural type...
December 14, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29288067/nationwide-trends-in-the-utilization-of-and-payments-for-hysterectomy-in-the-united-states-among-commercially-insured-women
#13
Daniel M Morgan, Neil S Kamdar, Carolyn W Swenson, Emily K Kobernik, Anne G Sammarco, Brahmajee Nallamothu
BACKGROUND: Laparotomy followed by inpatient hospitalization has traditionally been the most common surgical care for hysterectomy. The financial implications of the increased use of laparoscopy and outpatient hysterectomy are unknown. OBJECTIVES: To quantify the increasing use of laparoscopy and outpatient hysterectomy and to describe the financial implications among women with commercially based insurance in the United States. STUDY DESIGN: Hysterectomies between 2010 and 2013 were identified in the Health Care Cost Institute, a national dataset with inpatient and outpatient private insurance claims for more than 25 million women...
December 26, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29285023/treating-symptomatic-uterine-fibroids-with-myomectomy-current-practice-and-views-of-uk-consultants
#14
R Mallick, F Odejinmi
No abstract text is available yet for this article.
2017: Gynecological Surgery
https://www.readbyqxmd.com/read/29278943/a-retrospective-study-of-ultrasound-guided-high-intensity-focussed-ultrasound-ablation-for-multiple-uterine-fibroids-in-south-africa
#15
Min He, Hayley Jacobson, Cai Zhang, Raymond Setzen, Lian Zhang
OBJECTIVE: To evaluate the shrinkage rate, symptom relief and improvement of the quality of life following ultrasound-guided high intensity focussed ultrasound (USgHIFU) for multiple uterine fibroids. METHODS: From October 2015 to November 2016, 81 black women with multiple symptomatic fibroids underwent USgHIFU. The number of the fibroids ranged from 3 to 9. The shrinkage rate of fibroids, symptom severity score and quality of life were evaluated following USgHIFU...
January 5, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29274830/the-past-present-and-future-of-selective-progesterone-receptor-modulators-in-the-management-of-uterine-fibroids
#16
REVIEW
Sukhbir S Singh, Liane Belland, Nicholas Leyland, Sarah von Riedemann, Ally Murji
Uterine fibroids (UF) are common in women of reproductive age and can have a significant impact on quality of life and fertility. Although a number of international OB/GYN societies have issued evidence-based clinical practice guidelines for the management of symptomatic UF, many of these guidelines do not yet reflect the most recent clinical evidence and approved indication for one of the key medical management options: the selective progesterone receptor modulator (SPRM) class. This paper aims to share the clinical experience gained with SPRMs in Europe and Canada by reviewing the historical development of SPRMs, current best practices for SPRM use based on available data, and potential future uses for SPRMs in UF and other gynecologic conditions...
December 21, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29260904/ulipristal-acetate-for-the-management-of-acute-heavy-menstrual-bleeding-without-fibroids
#17
Josep Estadella, Pia Español, Fiorella Ascencio, Josep Perelló, Joaquim Calaf
Heavy menstrual bleeding is a common condition among women of childbearing age. Although hysterectomy was the usual approach in acute cases in the past, other minimally invasive therapies or pharmacological alternatives, such as the levonorgestrel intrauterine device have shown to be highly effective. This case report presents the case of a pluripathological patient with acute heavy menstrual bleeding and severe anemia, who was successfully managed with ulipristal acetate, a selective progesterone receptor modulator...
December 20, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29259861/inflammatory-fibroid-polyp-of-the-gastric-antrum-presenting-as-hypovolemic-shock-case-report-and-literature-review
#18
Kyle D Klingbeil, Alexandra Balaban, Raymond M Fertig, A Caresse Gamret, Yuna Gong, Carolyn Torres, Shevonne S Satahoo
Inflammatory fibroid polyps (IFP) are an extremely rare entity that arise within the submucosa of the gastrointestinal tract, and represent less than 0.1% of all gastric polyps. They are most commonly localized to the gastric antrum, small intestines and recto-sigmoid colon. IFPs are most commonly found incidentally upon endoscopic evaluation in the absence of symptoms. Presenting symptoms depend on the location of the tumor, although polyps located in the stomach most commonly present with epigastric pain and early satiety...
November 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29259779/uterine-fibroids-what-s-new
#19
REVIEW
Alistair R W Williams
Uterine fibroids are the commonest benign tumours of women and affect all races with a cumulative lifetime risk of around 70%. Despite their high prevalence and the heavy economic burden of treatment, fibroids have received remarkably little attention compared to common female malignant tumours. This article reviews recent progress in understanding the biological nature of fibroids, their life cycle and their molecular genetic origins. Recent progress in surgical and interventional management is briefly reviewed, and medical management options, including treatment with selective progesterone receptor modulators, are also discussed...
2017: F1000Research
https://www.readbyqxmd.com/read/29251677/indications-for-morcellation-in-gynecologic-surgery
#20
William H Parker
PURPOSE OF REVIEW: Minimally invasive gynecologic procedures, in particular laparoscopic hysterectomy and myomectomy, often require tissue morcellation. RECENT FINDINGS: Whether morcellated or not, myometrial cells can be found in the abdomen and pelvis after either laparoscopic or open myomectomy. Following morcellation, careful inspection for and removal of tissue fragments and copious irrigation and suctioning of fluid can remove residual tissue and cells without the use of containment bags...
February 2018: Current Opinion in Obstetrics & Gynecology
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