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https://www.readbyqxmd.com/read/29031144/senegenin-exerts-anti-depression-effect-in-mice-induced-by-chronic-un-predictable-mild-stress-via-inhibition-of-nf-%C3%AE%C2%BAb-regulating-nlrp3-signal-pathway
#1
Hongwei Li, Shiyi Lin, Tingting Qin, Hongyan Li, Zhanqiang Ma, Shiping Ma
Depressive disorder is a kind of affective disturbance disease. Emerging evidence has suggested that inflammation may contribute to the pathologic process of depressive disorder. Senegenin (SEN), a major bioactive constituent in Polygala tenuifolia Willd, has much bioactivity including anti-inflammatory and neuroprotection effects. However, the mechanism of its anti-depressant effect in mice remains unknown. This study aimed to explore the anti-depressant effects of SEN on behavioral changes and inflammatory responses in mice induced by chronic un-predictable mild stress (CUMS)...
October 11, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29028550/paternal-exposure-to-environmental-17-alpha-ethinylestradiol-concentrations-modifies-testicular-transcription-affecting-the-sperm-transcript-content-and-the-offspring-performance-in-zebrafish
#2
David G Valcarce, Elena Vuelta, Vanesa Robles, Maria Paz Herráez
The synthetic estrogen 17-α-ethinylestradiol (EE2), a major constituent in contraceptive pills, is an endocrine disrupting chemical (EDC) present in the aquatic environment at concentrations of ng/L. Developmental exposure to these low concentrations in fish can induce several disorders. Zebrafish (Danio rerio) is a perfect organism for monitoring the effects of environmental contaminants. Our hypothesis is that changes promoted by EE2 in the germ line of male adults could be transmitted to the unexposed progeny...
September 28, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/29027584/the-ceratopteris-fern-developing-motile-gamete-walls-contain-diverse%C3%A2-polysaccharides-but-not-pectin
#3
Renee A Lopez, Karen S Renzaglia
Unlike most plant cell walls, the five consecutive walls laid down during spermatogenesis in the model fern Ceratopteris contain sparse cellulose, lack pectin and are enriched with callose and hemicelluloses. Seed-free plants like bryophytes and pteridophytes produce swimming male gametes for sexual reproduction. During spermatogenesis, unique walls are formed that are essential to the appropriate development and maturation of the motile gametes. Other than the detection of callose and general wall polysaccharides in scattered groups, little is known about the sequence of wall formation and the composition of these walls during sperm cell differentiation in plants that produce swimming sperm...
October 13, 2017: Planta
https://www.readbyqxmd.com/read/29026523/medical-support-during-an-ironman-70-3-triathlon-race
#4
Hae-Rang Yang, Jinwoo Jeong, Injoo Kim, Ji Eun Kim
BACKGROUND: The Ironman 70.3 race is also called a half Ironman, and consists of 1.9 km of swimming, 90.1 km of cycling, and 21.1 km of running. The authors provide practical insights that may be useful for medical support in future events by summarizing the process and results of on-scene medical care. METHODS: The medical post was established at the transition area between the cycling and running courses, which was close to the finish line, and staffed with the headquarters team comprised of an emergency physician, an EMT, two nurses, and an ambulance with a driver...
2017: F1000Research
https://www.readbyqxmd.com/read/29026429/markers-of-neuroprotection-of-combined-epa-and-dha-provided-by-fish-oil-are-higher-than-those-of-epa-nannochloropsis-and-dha-schizochytrium-from-microalgae-oils-in-wistar-rats
#5
Paula A Lopes, Narcisa M Bandarra, Susana V Martins, Joana Martinho, Cristina M Alfaia, Marta S Madeira, Carlos Cardoso, Cláudia Afonso, Maria C Paulo, Rui M A Pinto, José L Guil-Guerrero, José A M Prates
BACKGROUND: To overcome the current overexploitation of fish rich in n-3 long chain polyunsaturated fatty acids (LCPUFA), microalgae have become a promising marine lipid source. The purpose of this study was to assess eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), isolated or combined from distinct marine origins, on the promotion of neuroprotective effects. METHODS: The experiment lasted for 10 weeks and involved 32 Wistar rats, divided into 4 diets (n = 8): a diet rich in milk fat was taken as control (Milk Fat) and compared to n-3 LCPUFA enriched diets, either in EPA + DHA form through fish oil (Fish Oil), or EPA through Nannochloropsis oil (Nanno), or DHA through Schizochytrium oil (Schyzo), while maintaining Milk Fat incorporation...
2017: Nutrition & Metabolism
https://www.readbyqxmd.com/read/29026130/effects-of-predator-lipids-on-dinoflagellate-defence-mechanisms-increased-bioluminescence-capacity
#6
Jenny Lindström, Wiebke Grebner, Kristie Rigby, Erik Selander
Short flashes of blue light (bioluminescence) from dinoflagellates can reduce copepod grazing of light-emitting cells. Other protective strategies against grazing are toxicity, reduced cell chain length and altered swimming patterns in different phytoplankton. Both toxicity and bioluminescence capacity in dinoflagellates decrease in copepod-free cultures, but toxin production can be restored in response to chemical alarm signals from copepods, copepodamides. Here we show that strains of the dinoflagellates Lingulodinium polyedra and Alexandrium tamarense, kept in culture for 14 and 9 years respectively, are capable of increasing their total bioluminescence capacity in response to copepodamides...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025407/severe-anemia-due-to-pharyngeal-leech-infestation-a%C3%A2-case-report-from-ethiopia
#7
Nebiyu Shitaye, Segenet Shibabaw
BACKGROUND: Leeches are rare blood-sucking endoparasites. Swimming in streams and ponds as well as drinking contaminated water are the major ways to acquire leeches. CASE PRESENTATION: A 6 year old boy who came with a history of hematemesis, frequent spitting of blood stained saliva, fatigue and anorexia to a rural hospital in Ethiopia. This was a rare case of severe anemia caused by a single leech infestation of laryngopharynx that required blood transfusion. CONCLUSION: Leech infestation should be considered as a source of unexplained hematemesis, spitting of blood and severe anemia in rural areas...
October 12, 2017: BMC Surgery
https://www.readbyqxmd.com/read/29025071/the-expression-characteristics-of-fam71d-and-its-association-with-sperm-motility
#8
Qian Ma, Yuchi Li, Manling Luo, Huan Guo, Shouren Lin, Jianbo Chen, Ye Du, Zhimao Jiang, Yaoting Gui
STUDY QUESTION: What are the features of FAM71D (Family with sequence similarity 71, member D) expression and is there an association between FAM71D expression and sperm motility? SUMMARY ANSWER: FAM71D, a novel protein exclusively expressed in the testis, is located in sperm flagella and is functionally involved in sperm motility. WHAT IS KNOWN ALREADY: Some testis-specific proteins have been reported as potential diagnostic biomarkers to evaluate the spermatogenesis process and sperm quality...
September 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29024898/maternal-and-embryonic-exposure-to-the-water-soluble-fraction-of-crude-oil-or-lead-induces-behavioral-abnormalities-in-zebrafish-danio-rerio-and-the-mechanisms-involved
#9
Yuanchuan Wang, Chao Shen, Chonggang Wang, Yixi Zhou, Dongxu Gao, Zhenghong Zuo
The water-soluble fraction (WSF) of crude oil plays an important role in the toxicity of crude oil in aquatic environments. Heavy metals, such as lead (Pb) are also important environmental contaminants, which can reach aquatic systems via the effluents of industrial, urban and mining sources. In the present study, we investigated whether maternal and embryonic exposure to the WSF (5, 50 μg/L) or Pb (10, 100 μg/L) could induce behavioral abnormalities in zebrafish. Our results showed that maternal and embryonic exposure to the WSF (5, 50 μg/L) and Pb (10, 100 μg/L) induced swimming activity alterations in larval and juvenile zebrafish...
September 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/29023496/pacing-the-phasing-of-leg-and-arm-movements-in-breaststroke-swimming-to-minimize-intra-cyclic-velocity-fluctuations
#10
Josje van Houwelingen, Melvyn Roerdink, Alja V Huibers, Lotte L W Evers, Peter J Beek
In swimming propelling efficiency is partly determined by intra-cyclic velocity fluctuations. The higher these fluctuations are at a given average swimming velocity, the less efficient is the propulsion. This study explored whether the leg-arm coordination (i.e. phase relation ϕ) within the breaststroke cycle can be influenced with acoustic pacing, and whether the so induced changes are accompanied by changes in intra-cyclic velocity fluctuations. Twenty-six participants were asked to couple their propulsive leg and arm movements to a double-tone metronome beat and to keep their average swimming velocity constant over trials...
2017: PloS One
https://www.readbyqxmd.com/read/29022796/aural-exostoses-surfer-s-ear-provide-vital-fossil-evidence-of-an-aquatic-phase-in-man-s-early-evolution
#11
P H Rhys Evans, M Cameron
For over a century, otolaryngologists have recognised the condition of aural exostoses, but their significance and aetiology remains obscure, although they tend to be associated with frequent swimming and cold water immersion of the auditory canal. The fact that this condition is usually bilateral is predictable since both ears are immersed in water. However, why do exostoses only grow in swimmers and why do they grow in the deep bony meatus at two or three constant sites? Furthermore, from an evolutionary point of view, what is or was the purpose and function of these rather incongruous protrusions? In recent decades, paleoanthropological evidence has challenged ideas about early hominid evolution...
September 15, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/29022517/do-contamination-of-and-exposure-to-chicken-meat-and-water-drive-the-temporal-dynamics-of-campylobacter-cases
#12
J M David, F Pollari, K D M Pintar, A Nesbitt, A J Butler, A Ravel
Campylobacteriosis, the most frequent bacterial enteric disease, shows a clear yet unexplained seasonality. The study purpose was to explore the influence of seasonal fluctuation in the contamination of and in the behaviour exposures to two important sources of Campylobacter on the seasonality of campylobacteriosis. Time series analyses were applied to data collected through an integrated surveillance system in Canada in 2005-2010. Data included sporadic, domestically-acquired cases of Campylobacter jejuni infection, contamination of retail chicken meat and of surface water by C...
October 12, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29022257/acute-and-chronic-exercise-in-animal-models
#13
Vu Thi Thu, Hyoung Kyu Kim, Jin Han
Numerous animal cardiac exercise models using animal subjects have been established to uncover the cardiovascular physiological mechanism of exercise or to determine the effects of exercise on cardiovascular health and disease. In most cases, animal-based cardiovascular exercise modalities include treadmill running, swimming, and voluntary wheel running with a series of intensities, times, and durations. Those used animals include small rodents (e.g., mice and rats) and large animals (e.g., rabbits, dogs, goats, sheep, pigs, and horses)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29022188/swimming-in-a-tsunami-of-change
#14
Saad Y Salim, Jonathan White
No abstract text is available yet for this article.
October 11, 2017: Advances in Health Sciences Education: Theory and Practice
https://www.readbyqxmd.com/read/29021905/the-waterpolo-shoulder-paradigm-results-of-ultrasound-surveillance-at-poolside
#15
Felice Galluccio, Eleonora Bellucci, Francesco Porta, Lorenzo Tofani, Amato De Paulis, Diana Bianchedi, Tatiana Barskova, Marco Matucci-Cerinic
BACKGROUND: Waterpolo consists of a combination of swimming and throwing with close contact between players. The shoulder is the most frequently injured joint, with a combination of rotator cuff tear and tendinopathy, long head biceps tendinopathy, superior labral lesions and shoulder impingement. This unique combination is a challenge for the clinician who must determine which of these shoulder pathologies is responsible for the onset of pain and the best strategy to rehabilitate the joint and prevent recurrence...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29021593/a-coordinated-sequence-of-distinct-flagellar-waveforms-enables-a-sharp-flagellar-turn-mediated-by-squid-sperm-ph-taxis
#16
Tomohiro Iida, Yoko Iwata, Tatsuma Mohri, Shoji A Baba, Noritaka Hirohashi
Animal spermatozoa navigate by sensing ambient chemicals to reach the site of fertilization. Generally, such chemicals derive from the female reproductive organs or cells. Exceptionally, squid spermatozoa mutually release and perceive carbon dioxide to form clusters after ejaculation. We previously identified the pH-taxis by which each spermatozoon can execute a sharp turn, but how flagellar dynamics enable this movement remains unknown. Here, we show that initiation of the turn motion requires a swim down a steep proton gradient (a theoretical estimation of ≥0...
October 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021391/a-dual-axis-rotation-rule-for-updating-the-head-direction-cell-reference-frame-during-movement-in-three-dimensions
#17
Hector J I Page, Jonathan J Wilson, Kate J Jeffery
In the mammalian brain, allocentric (Earth-referenced) head direction, called azimuth, is encoded by head direction (HD) cells, which fire according to the facing direction of the animal's head. On a horizontal surface, rotations of the head around the dorso-ventral (D-V) axis, called yaw, correspond to changes in azimuth, and elicit appropriate updating of the HD 'compass' signal to enable large-scale navigation. However, if the animal moves through three-dimensional (3D) space then there is no longer a simple relationship between yaw rotations and azimuth changes, and so processing of three-dimensional rotations is needed...
October 11, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29020418/striatal-n-acetylaspartate-synthetase-shati-nat8l-regulates-depression-like-behaviors-via-mglur3-mediated-serotonergic-suppression-in-mice
#18
Yoshiaki Miyamoto, Noriyuki Iegaki, Kequan Fu, Yudai Ishikawa, Kazuyuki Sumi, Sota Azuma, Kyosuke Uno, Shin-Ichi Muramatsu, Atsumi Nitta
Background: Several clinical studies have suggested that N-acetylaspartate (NAA) and N-acetylaspartylglutamate (NAAG) levels in the human brain are associated with various psychiatric disorders, including major depressive disorder. We have previously identified Shati/Nat8l, an N-acetyltransferase, in the brain using an animal model of psychosis. Shati/Nat8l synthesizes NAA from L-aspartate and acetyl-coenzyme A. Further, NAA is converted into NAAG, a neurotransmitter for metabotropic glutamate receptor 3 (mGluR3)...
August 31, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29020410/the-requirement-of-l-type-voltage-dependent-calcium-channel-l-vdcc-in-the-rapid-acting-antidepressant-like-effects-of-scopolamine-in-mice
#19
Hanjie Yu, Mengmeng Li, Xinbei Shen, Dan Lv, Xin Sun, Jinting Wang, Xinmei Gu, Jingning Hu, Chuang Wang
Background: Previous studies have shown that a low dose of scopolamine produces rapid-acting antidepressant-like actions in rodents. Understanding the mechanisms underlying this effect and the dose-dependent variations of drug responses remains an important task. L-type voltage-dependent calcium channels (L-VDCC) were found to mediate rapid-acting antidepressant effects of certain medications (e.g., ketamine). Therefore, it is of great interest to determine the involvement of L-VDCC in the action of scopolamine...
August 25, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29019029/hippocampal-acetylation-may-improve-prenatal-stress-induced-depression-like-behavior-of-male-offspring-rats-through-regulating-ampars-expression
#20
Yong Lu, Junli Zhang, Lin Zhang, Shaokang Dang, Qian Su, Huiping Zhang, Tianwei Lin, Xiaoxiao Zhang, Yurong Zhang, Hongli Sun, Zhongliang Zhu, Hui Li
This study is to determine the role and mechanism of hippocampal acetylation in prenatal stress (PS) induced depression-like behavior of male offspring rats. PS-induced depression rat model was established. Sucrose preference and forced swim test were used to observe the behavior changes of male offspring rats. Hippocampal acetylation was induced by Trichostatin A injection. Quantitative real-time PCR and Western blot were used to determine the changes of AMPARs in acetylated hippocampus. The behavioral tests proved that AMPA was involved in the PS-induced depression-like behavior in offspring rats...
October 10, 2017: Neurochemical Research
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