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JOURNAL ARTICLE
Sean Coeckelenbergh, Maxim Soucy-Proulx, Philippe Van der Linden, Matthieu Clanet, Joseph Rinehart, Maxime Cannesson, Jacques Duranteau, Alexandre Joosten
Intensive care unit (ICU) nurses frequently manually titrate norepinephrine to maintain a predefined mean arterial pressure (MAP) target after high-risk surgery. However, achieving this task is often suboptimal. We have developed a closed-loop vasopressor (CLV) controller to better maintain MAP within a narrow range. After ethical committee approval, fifty-three patients admitted to the ICU following high-risk abdominal surgery were randomized to CLV or manual norepinephrine titration. In both groups, the aim was to maintain MAP in the predefined target of 80-90 mmHg...
December 18, 2023: Journal of Clinical Monitoring and Computing
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JOURNAL ARTICLE
Johannie Audet, Charly G Lecomte, Jonathan Harnie, Sirine Yassine, Rasha Al Arab, Félix Soucy, Caroline Morency, Stephen Mari, Pierre Jéhannin, Angèle N Merlet, Alain Frigon
Mammals walk in different directions, such as forward and backward. In human infants/adults and decerebrate cats, one leg can walk forward and the other backward simultaneously on a split-belt treadmill, termed hybrid or bidirectional locomotion. The purpose of the present study was to determine if spinal sensorimotor circuits generate hybrid locomotion and if so, how the limbs remain coordinated. We tested hybrid locomotion in 11 intact cats and in five following complete spinal thoracic transection (spinal cats) at three treadmill speeds with the hindlimbs moving forward, backward or bidirectionally...
November 28, 2023: Journal of Physiology
#23
JOURNAL ARTICLE
Benjamin Littenberg, Jessica Clifton, Abigail M Crocker, Laura-Mae Baldwin, Levi N Bonnell, Ryan E Breshears, Peter Callas, Prama Chakravarti, Kelly Clark/Keefe, Deborah J Cohen, Frank V deGruy, Lauren Eidt-Pearson, William Elder, Chester Fox, Sylvie Frisbie, Katie Hekman, Juvena Hitt, Jennifer Jewiss, David C Kaelber, Kairn Stetler Kelley, Rodger Kessler, Jennifer B O'Rourke-Lavoie, George S Leibowitz, C R Macchi, Matthew P Martin, Mark McGovern, Brenda Mollis, Daniel Mullin, Zsolt Nagykaldi, Lisa W Natkin, Wilson Pace, Richard G Pinckney, Douglas Pomeroy, Paula Reynolds, Gail L Rose, Sarah Hudson Scholle, William J Sieber, Jeni Soucie, Terry Stancin, Kurt C Stange, Kari A Stephens, Kathryn Teng, Elizabeth Needham Waddell, Constance van Eeghen
PURPOSE: Patient outcomes can improve when primary care and behavioral health providers use a collaborative system of care, but integrating these services is difficult. We tested the effectiveness of a practice intervention for improving patient outcomes by enhancing integrated behavioral health (IBH) activities. METHODS: We conducted a pragmatic, cluster randomized controlled trial. The intervention combined practice redesign, quality improvement coaching, provider and staff education, and collaborative learning...
2023: Annals of Family Medicine
#24
JOURNAL ARTICLE
Cristiano Schaffer Aguzzoli, Pâmela C L Ferreira, Guilherme Povala, João Pedro Ferrari-Souza, Bruna Bellaver, Carolina Soares Katz, Hussein Zalzale, Firoza Z Lussier, Francieli Rohden, Sarah Abbas, Douglas T Leffa, Marina Scop Medeiros, Joseph Therriault, Andréa L Benedet, Cécile Tissot, Stijn Servaes, Nesrine Rahmouni, Arthur Cassa Macedo, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Vanessa Pallen, Ann Cohen, Oscar L Lopez, Dana L Tudorascu, William E Klunk, Victor L Villemagne, Jean Paul Soucy, Eduardo R Zimmer, Lucas P Schilling, Thomas K Karikari, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Serge Gauthier, Victor Valcour, Bruce L Miller, Pedro Rosa-Neto, Tharick A Pascoal
IMPORTANCE: Neuropsychiatric symptoms are commonly encountered and are highly debilitating in patients with Alzheimer disease. Understanding their underpinnings has implications for identifying biomarkers and treatment for these symptoms. OBJECTIVE: To evaluate whether glial markers are associated with neuropsychiatric symptoms in individuals across the Alzheimer disease continuum. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study was conducted from January to June 2023, leveraging data from the Translational Biomarkers in Aging and Dementia cohort at McGill University, Canada...
November 1, 2023: JAMA Network Open
#25
JOURNAL ARTICLE
Hussein Bdair, Min Su Kang, Julie Ottoy, Arturo Aliaga, Peter Kunach, Thomas A Singleton, Stephan Blinder, Jean-Paul Soucy, Marco Leyton, Pedro Rosa-Neto, Alexey Kostikov
Positron emission tomography (PET) is a noninvasive functional imaging modality that involves in vivo detection of spatiotemporal changes in the binding of radioactive pharmaceuticals (a.k.a. PET tracers) to their target sites in different organs. The development of new PET tracers commonly involves their preclinical evaluation in small rodents. Moreover, laboratory animal PET research is now being used with progressively greater frequency to complement human PET studies, to investigate in greater depth the underlying pathophysiology of human diseases, and to monitor the efficiency of novel therapeutic interventions...
2024: Methods in Molecular Biology
#26
JOURNAL ARTICLE
Jonathan R Soucy, Levi Todd, Emil Kriukov, Monichan Phay, Volha V Malechka, John Dayron Rivera, Thomas A Reh, Petr Baranov
Ongoing cell therapy trials have demonstrated the need for precision control of donor cell behavior within the recipient tissue. We present a methodology to guide stem cell-derived and endogenously regenerated neurons by engineering the microenvironment. Being an "approachable part of the brain," the eye provides a unique opportunity to study neuron fate and function within the central nervous system. Here, we focused on retinal ganglion cells (RGCs)-the neurons in the retina are irreversibly lost in glaucoma and other optic neuropathies but can potentially be replaced through transplantation or reprogramming...
November 14, 2023: Proceedings of the National Academy of Sciences of the United States of America
#27
JOURNAL ARTICLE
Clyde J Belasso, Zhengchen Cai, Gleb Bezgin, Tharick Pascoal, Jenna Stevenson, Nesrine Rahmouni, Cécile Tissot, Firoza Lussier, Pedro Rosa-Neto, Jean-Paul Soucy, Hassan Rivaz, Habib Benali
BACKGROUND: Alzheimer's disease (AD) diagnosis in its early stages remains difficult with current diagnostic approaches. Though tau neurofibrillary tangles (NFTs) generally follow the stereotypical pattern described by the Braak staging scheme, the network degeneration hypothesis (NDH) has suggested that NFTs spread selectively along functional networks of the brain. To evaluate this, we implemented a Bayesian workflow to develop hierarchical multinomial logistic regression models with increasing levels of complexity of the brain from tau-PET and structural MRI data to investigate whether it is beneficial to incorporate network-level information into an ROI-based predictive model for the presence/absence of AD...
2023: Frontiers in Aging Neuroscience
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JOURNAL ARTICLE
John Broach, Olga Brown, Caitlin McEachern, Janell Forget, Peter Lancette, Norman Soucie, Julie Inzerillo, Robert Klugman, Stephen Tosi, Abraham Haddad, Pamela Manor, Richard Bylund, Gio Dellostritto, Max Grecchi, Connie Camelo, Jeanne Shirshac, Katharine Eshghi, Nardy Vega, Stacy Hampson, Kassandra Follwell, Rafael Gonzalez, Theresa Hicks, Victoria McCandless, Timothy VanStratten, Mina Botros, Tracy Jalbert, Catherine Merwin, Wendy Schellhammer, Ian Pelto, Maggie Rodriguez, Cheryl LaPriore, Monica Lowell, Elizabeth Radigan, Lorie Gull, Alana Gruszecki, Sarah Benoit, Eric Dickson, Michelle Muller
The SARS CoV-2 (COVID-19) pandemic presented unprecedented challenges as communities attempted to respond to the administration of a novel vaccine that faced cold chain logistical requirements and vaccine hesitancy among many, as well as complicated phased rollout plans that changed frequently as availability of the vaccine waxed and waned. The COVID-19 pandemic also disproportionately affected communities of color and communities with barriers to accessing healthcare. In the setting of these difficulties, a program was created specifically to address inequity in vaccine administration with a focus on communities of color and linguistic diversity as well as those who had technological barriers to online sign-up processes common at mass vaccination sites...
2023: Frontiers in Public Health
#29
JOURNAL ARTICLE
Alexander Thiel, Alexey Kostikov, Hailey Ahn, Youstina Daoud, Jean-Paul Soucy, Stephan Blinder, Carolin Jaworski, Carmen Wängler, Björn Wängler, Freimut Juengling, Shirin A Enger, Ralf Schirrmacher
BACKGROUND: Reduced expression or impaired signalling of tropomyosin receptor kinases (Trk receptors) are found in a vast spectrum of CNS disorders. [18 F]TRACK is the first PET radioligand for TrkB/C with proven in vivo brain penetration and on-target specific signal. Here we report dosimetry data for [18 F]TRACK in healthy humans. 6 healthy participants (age 22-61 y, 3 female) were scanned on a General Electric Discovery PET/CT 690 scanner. [18 F]TRACK was synthesized with high molar activities (Am = 250 ± 75 GBq/µmol), and a dynamic series of 12 whole-body scans were acquired after injection of 129 to 147 MBq of the tracer...
October 23, 2023: EJNMMI Radiopharmacy and Chemistry
#30
JOURNAL ARTICLE
Milad Soltanzadeh, Solenna Blanchard, Jean-Paul Soucy, Habib Benali
It is well known that glucose serves as the main energy substrate for the brain, and emerging evidence emphasizes its involvement in both physiological processes and disease (traumatic brain injury, memory, epilepsy, etc.). Furthermore, the usefulness of mathematical modeling in deciphering underlying dynamics of the brain to investigate lactate roles and mechanisms of action has been well established. Here, we analyze a novel mathematical model of brain lactate exchanges between four compartments: neurons, astrocytes, capillaries, and extracellular space...
October 19, 2023: Journal of Theoretical Biology
#31
Peter Kunach, Jaime Vaquer-Alicea, Matthew S Smith, Robert Hopewell, Jim Monistrol, Luc Moquin, Joseph Therriault, Cecile Tissot, Nesrine Rahmouni, Gassan Massarweh, Jean-Paul Soucy, Marie-Christine Guiot, Brian K Shoichet, Pedro Rosa-Neto, Marc I Diamond, Sarah H Shahmoradian
Positron Emission Tomography (PET) ligands have advanced Alzheimer's disease (AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identified AD brain tissue with elevated tau burden, purified filaments, and determined the structure of second-generation high avidity PET ligand MK-6240 at 2.31 Å resolution, which bound at a 1:1 ratio within the cleft of tau paired-helical filament (PHF), engaging with glutamine 351, lysine K353, and isoleucine 360. This information elucidates the basis of MK-6240 PET in quantifying PHF deposits in AD and may facilitate the structure-based design of superior ligands against tau amyloids...
September 22, 2023: bioRxiv
#32
JOURNAL ARTICLE
Dana B McCarty, Stacey C Dusing, Alana Gilbert, Kristen D LeBlond, Meredith Soucie, T Michael O'Shea
Mothers of extremely preterm infants experience high rates of mental health disorders that impair maternal-infant interaction and lead to worse infant developmental outcomes. Therapist Education and Massage for Parent-Infant Outcomes (TEMPO) is a therapist-led program that standardizes the nature and frequency of parent education through weekly scheduled therapy sessions. Using a family-centered approach, the therapist facilitates positive maternal-infant interactions and massage interventions from birth throughout hospitalization with the goal of improving maternal mental health...
August 25, 2023: Children
#33
Naomi Wilcox, Martine Dumont, Anna González-Neira, Sara Carvalho, Charles Joly Beauparlant, Marco Crotti, Craig Luccarini, Penny Soucy, Stéphane Dubois, Rocio Nuñez-Torres, Guillermo Pita, Eugene J Gardner, Joe Dennis, M Rosario Alonso, Nuria Álvarez, Caroline Baynes, Annie Claude Collin-Deschesnes, Sylvie Desjardins, Heiko Becher, Sabine Behrens, Manjeet K Bolla, Jose E Castelao, Jenny Chang-Claude, Sten Cornelissen, Thilo Dörk, Christoph Engel, Manuela Gago-Dominguez, Pascal Guénel, Andreas Hadjisavvas, Eric Hahnen, Mikael Hartman, Belén Herráez, Audrey Jung, Renske Keeman, Marion Kiechle, Jingmei Li, Maria A Loizidou, Michael Lush, Kyriaki Michailidou, Mihalis I Panayiotidis, Xueling Sim, Soo Hwang Teo, Jonathan P Tyrer, Lizet E van der Kolk, Cecilia Wahlström, Qin Wang, John R B Perry, Javier Benitez, Marjanka K Schmidt, Rita K Schmutzler, Paul D P Pharoah, Arnaud Droit, Alison M Dunning, Anders Kvist, Peter Devilee, Douglas F Easton, Jacques Simard
No abstract text is available yet for this article.
September 26, 2023: Nature Genetics
#34
JOURNAL ARTICLE
João Pedro Ferrari-Souza, Bruna Bellaver, Pâmela C L Ferreira, Andréa L Benedet, Guilherme Povala, Firoza Z Lussier, Douglas T Leffa, Joseph Therriault, Cécile Tissot, Carolina Soares, Yi-Ting Wang, Mira Chamoun, Stijn Servaes, Arthur C Macedo, Marie Vermeiren, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, Ann Cohen, Oscar L Lopez, William E Klunk, Jean-Paul Soucy, Serge Gauthier, Diogo O Souza, Gallen Triana-Baltzer, Ziad S Saad, Hartmuth C Kolb, Thomas K Karikari, Victor L Villemagne, Dana L Tudorascu, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Eduardo R Zimmer, Pedro Rosa-Neto, Tharick A Pascoal
The mechanisms by which the apolipoprotein E ε4 (APOEε4) allele influences the pathophysiological progression of Alzheimer's disease (AD) are poorly understood. Here we tested the association of APOEε4 carriership and amyloid-β (Aβ) burden with longitudinal tau pathology. We longitudinally assessed 94 individuals across the aging and AD spectrum who underwent clinical assessments, APOE genotyping, magnetic resonance imaging, positron emission tomography (PET) for Aβ ([18 F]AZD4694) and tau ([18 F]MK-6240) at baseline, as well as a 2-year follow-up tau-PET scan...
October 2023: Nature aging
#35
REVIEW
Jonathan R Soucy, Erika A Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A Saleem, Xue-Wei Wang, Juilette Wohlschlegel, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K Gokoffski, Jeffrey L Goldberg, William Guido, Alex L Kolodkin, Carol A Mason, Yvonne Ou, Thomas A Reh, Ahmara G Ross, Brian C Samuels, Derek Welsbie, Donald J Zack, Thomas V Johnson
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in irreversible vision loss due to the mammalian central nervous system's limited regenerative capacity. RGC repopulation is a promising therapeutic approach to reverse vision loss from optic neuropathies if the newly introduced neurons can reestablish functional retinal and thalamic circuits. In theory, RGCs might be repopulated through the transplantation of stem cell-derived neurons or via the induction of endogenous transdifferentiation...
September 21, 2023: Molecular Neurodegeneration
#36
JOURNAL ARTICLE
David Henault, David Stephen, Pierre-Antoine St-Hilaire, Nouredin Messaoudi, Franck Vandenbroucke-Menu, Eve Simoneau, Zhixia Rong, Marylène Plasse, Richard Létourneau, André Roy, Michel Dagenais, Réal Lapointe, Bich Nguyen, Anne-Marie Mes-Masson, G Soucy, Simon Turcotte
In colorectal cancer liver metastases (CRLM), the density of tumor-infiltrating lymphocytes, the expression of class I major histocompatibility complex (MHC-I), and the pathological response to preoperative chemotherapy have been associated with oncological outcomes after complete resection. However, the prognostic significance of the heterogeneity of these features in patients with multiple CRLMs remains under investigation. We used a tissue microarray of 220 mismatch repair-gene proficient CRLMs resected in 97 patients followed prospectively to quantify CD3+ T cells and MHC-I by immunohistochemistry...
2023: Oncoimmunology
#37
JOURNAL ARTICLE
Joseph Therriault, Firoza Z Lussier, Cécile Tissot, Mira Chamoun, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Gleb Bezgin, Stijn Servaes, Peter Kunach, Yi-Ting Wang, Jaime Fernandez-Arias, Marie Vermeiren, Tharick A Pascoal, Gassan Massarweh, Paolo Vitali, Jean-Paul Soucy, Paramita Saha-Chaudhuri, Serge Gauthie, Pedro Rosa-Neto
INTRODUCTION: [18F]AZD4694 is an amyloid beta (Aβ) imaging agent used in several observational studies and clinical trials. However, no studies have yet published data on longitudinal Aβ accumulation measured with [18F]AZD4694. METHODS: We assessed 146 individuals who were evaluated with [18F]AZD4694 at baseline and 2-year follow-up. We calculated annual rates of [18F]AZD4694 change for clinically defined and biomarker-defined groups. RESULTS: Cognitively unimpaired (CU) older adults displayed subtle [18F]AZD4694 standardized uptake value ratio (SUVR) accumulation over the follow-up period...
2023: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
#38
JOURNAL ARTICLE
Béatrice Soucy, Dillon Lee, Amélie Moreau-Bourbonnais, Marc Filiatrault, Isabelle Denis, Min Cheol Chang, Mathieu Boudier-Revéret
INTRODUCTION: Fluoroscopic guidance has become the standard for a variety of medical procedures. Mastering these techniques requires practice, which may entail additional radiation for patients and providers. Despite their widespread use, the literature examining factors influencing radiation exposure in fluoroscopically guided pain procedures is scarce. OBJECTIVE: To evaluate the influence of resident involvement on radiation exposure during fluoroscopy-guided spinal interventions...
August 28, 2023: PM & R: the Journal of Injury, Function, and Rehabilitation
#39
JOURNAL ARTICLE
Margot Cazals, Emilie Bédard, Chantal Soucy, Patrice Savard, Michèle Prévost
BACKGROUND: Ice machines in healthcare facilities have been suspected and even linked to outbreaks and pseudo-outbreaks. Guidelines exist for maintenance of these devices but there is no clear independent infection control standard, and little is known on their microbial contamination. AIM: To evaluate the microbial contamination, amplification, and presence of opportunistic pathogens in ice-water machines in a healthcare facility. METHODS: Concentrations of general microbial indicators (heterotrophic plate counts (HPC), total and intact cells), faecal indicators (enterococci) and opportunistic pathogens (Pseudomonas aeruginosa, nontuberculous mycobacteria (NTM), Candida spp...
August 19, 2023: Journal of Hospital Infection
#40
JOURNAL ARTICLE
Carolina Lyon De Ana, Anukul T Shenoy, Kimberly A Barker, Emad I Arafa, Neelou S Etesami, Filiz T Korkmaz, Alicia M Soucy, Michael P Breen, Ian M C Martin, Brian R Tilton, Priyadharshini Devarajan, Nicholas A Crossland, Riley M F Pihl, Wesley N Goltry, Anna C Belkina, Matthew R Jones, Lee J Quinton, Joseph P Mizgerd
Streptococcus pneumoniae is the most common etiology of bacterial pneumonia, one of the leading causes of death in children and the elderly worldwide. During non-lethal infections with S. pneumoniae, lymphocytes accumulate in the lungs and protect against reinfection with serotype-mismatched strains. CD4+ resident memory T (TRM ) cells are known to be crucial for this protection, but the diversity of lung CD4+ TRM cells has yet to be fully delineated. We aimed to identify unique subsets and their contributions to lung immunity...
August 19, 2023: Mucosal Immunology
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