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https://www.readbyqxmd.com/read/28332239/clinical-application-of-calculated-split-renal-volume-using-computed-tomography-based-renal-volumetry-after-partial-nephrectomy-correlation-with-technetium-99m-dimercaptosuccinic-acid-renal-scan-data
#1
Chan Ho Lee, Young Joo Park, Ja Yoon Ku, Hong Koo Ha
OBJECTIVE: To evaluate the clinical application of computed tomography-based measurement of renal cortical volume and split renal volume as a single tool to assess the anatomy and renal function in patients with renal tumors before and after partial nephrectomy, and to compare the findings with technetium-99m dimercaptosuccinic acid renal scan. METHODS: The data of 51 patients with a unilateral renal tumor managed by partial nephrectomy were retrospectively analyzed...
March 22, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28331057/upregulation-of-distinct-collagen-transcripts-in-post-surgery-scar-tissue-a-study-of-conjunctival-fibrosis
#2
Li-Fong Seet, Li Zhen Toh, Stephanie W L Chu, Sharon N Finger, Jocelyn L L Chua, Tina T Wong
Excessive accumulation of collagen is often used to assess the development of fibrosis. This study aims to identify collagen genes that define fibrosis in the conjunctiva following glaucoma filtration surgery (GFS). Using the mouse model of GFS, we have identified collagen transcripts that were upregulated in the fibrotic phase of wound healing via RNA-seq. The top three highest induced collagen transcripts belong to Col8a1, Col11a1 and Col8a2 Further validation of the Col8a1, Col11a1 and Col8a2 transcripts revealed their increase by 67-, 54- and 18-folds respectively in the fibrotic phase, compared to 12-fold for Col1a1, the most commonly evaluated collagen gene for fibrosis...
March 22, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28319643/grooved-glaucoma-drainage-devices-that-continuously-deliver-cyclosporine-a-decrease-postsurgical-scar-formation-in-rabbit-eyes
#3
Zhaoxing Dai, Xiaobo Yu, Jianguo Sun, Xinghuai Sun
Purpose: To study the functional outcomes of filtration surgery by implanting improved glaucoma drainage devices (GDDs) comprising surface grooves and a composite coating of cyclosporine A (CsA) and PLGA in experimental rabbit eyes. Methods: Improved GDDs were designed and prepared by modifying normal GDD with surface grooves and a CsA-PLGA composite coating. Normal GDDs, grooved GDDs (G-GDDs), and G-GDDs with a CsA-PLGA composite coating (CsA@G-GDD) were implanted into 18 rabbit eyes (six eyes per group)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28283892/a-review-of-the-ahmed-glaucoma-valve-implant-and-comparison-with-other-surgical-operations
#4
REVIEW
Ivano Riva, Gloria Roberti, Andreas Katsanos, Francesco Oddone, Luciano Quaranta
The Ahmed glaucoma valve (AGV) is a popular glaucoma drainage implant used for the control of intraocular pressure in patients with glaucoma. While in the past AGV implantation was reserved for glaucoma patients poorly controlled after one or more filtration procedures, mounting evidence has recently encouraged its use as a primary surgery in selected cases. AGV has been demonstrated to be safe and effective in reducing intraocular pressure in patients with primary or secondary refractory glaucoma. Compared to other glaucoma surgeries, AGV implantation has shown favorable efficacy and safety...
March 11, 2017: Advances in Therapy
https://www.readbyqxmd.com/read/28271700/the-actual-role-of-robotics-in-the-management-of-endometriosis
#5
Vito Cela, Maria E Obino, Claudia Sergiampietri, Giovanna Simi, Francesca Papini, Sara Pinelli, Letizia Freschi, Paolo G Artini
The advent of robot-assisted laparoscopy (RAL) represents an important innovation and has opened new perspectives for treatment of endometriosis, in particular in deep infiltrating endometriosis (DIE). RAL could offer several technical advantages in treating this complex disease, such as 3D vision, tremor filtration and better surgical ergonomy, would be able to improve surgical performances without increasing in surgical time, blood loss, intra- and postoperative complications and it reduces the rates of conversion to laparotomy...
March 7, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28263109/glomerular-filtration-rate-determination-by-computed-tomography-in-two-pet-rabbits-with-renal-disease
#6
Graham Zoller, Isabelle Langlois, Kate Alexander
CASE DESCRIPTION A 3-year-old and a 7-year-old spayed female rabbit (Oryctolagus cuniculus) were evaluated because of digestive stasis associated with renal asymmetry. CLINICAL FINDINGS Neoplasia of the right kidney was diagnosed via cytologic analysis in the 3-year-old rabbit. Ureterolithiasis of the left kidney was diagnosed via abdominal ultrasonography in the 7-year-old rabbit. To evaluate whether unilateral nephrectomy was indicated, evaluation of glomerular filtration rate by dynamic CT (CT-GFR) was performed on both rabbits...
March 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28259474/excisional-precision-matters-understanding-the-influence-of-excisional-volume-loss-on-renal-function-after-partial-nephrectomy
#7
Julien Dagenais, Matthew J Maurice, Pascal Mouracade, Onder Kara, Ercan Malkoc, Jihad H Kaouk
Renal function after partial nephrectomy (PN) may depend on modifiable factors including ischemia time, excision of healthy parenchyma (excisional volume loss, EVL), and reconstructive methods. We retrospectively reviewed our institutional robotic PN database to identify the predictors of glomerular filtration rate (GFR) preservation (GFR-P) at 3-12 mo postoperatively, during which GFR decline plateaus. Baseline clinical, sociodemographic, and radiologic characteristics were captured. Univariate and multivariate (MV) linear regression analyses were performed and marginal effects were employed to examine the relative effect of EVL on renal function...
March 1, 2017: European Urology
https://www.readbyqxmd.com/read/28257136/surgical-management-of-malignant-glaucoma-a-retrospective-analysis-of-fifty-eight-eyes
#8
S Balekudaru, N S Choudhari, P Rewri, R George, P S Bhende, M Bhende, V Lingam, G Lingam
PurposeTo assess outcomes of surgical management of malignant glaucoma in terms of re-formation of anterior chamberMethodsThis was a retrospective analysis of consecutive patients who underwent surgical treatment for malignant glaucoma between January 1995 and December 2013 at a tertiary care ophthalmic institute, with a minimum follow up of 2 months.ResultsFifty eight eyes of 58 patients were included. Fifty two (89.7%) patients had primary angle closure glaucoma. The majority had undergone glaucoma filtration surgery earlier (n=53, 91...
March 3, 2017: Eye
https://www.readbyqxmd.com/read/28256495/the-evaluation-of-renal-parenchymal-scarring-using-static-renal-scintigraphy-after-percutaneous-nephrolithotomy-operations
#9
S Yalcinkaya, N Ates, M Yuksel, E Islamoglu, H Tokgoz, E U Ates, A Yildız, S Yilmaz, M Savas
OBJECTIVE: To analyze whether operative techniques and other variables related to patient and renal stone characteristics affect potential renal parenchymal damage. MATERIALS AND METHODS: The study population comprised 64 patients who underwent percutaneous nephrolithotomy operations (PCNL). Data of the operated renal units, renal stone burden, route and number of entries, dilation techniques, duration of surgery, preoperative and postoperative glomerular filtration rate (GFR) and relative dimercaptosuccinic acid (DMSA) uptakes, as well as the changes in hemoglobin values, were recorded and analyzed for all patients...
March 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28255639/cisplatin-nephrotoxicity-is-not-detected-by-urinary-cell-cycle-arrest-biomarkers-in-lung-cancer-patients
#10
Zeki Toprak, Egemen Cebeci, Serife Aysen Helvaci, Ilkim Deniz Toprak, Yasin Kutlu, Abdullah Sakin, Tufan Tukek
PURPOSE: Cisplatin is a chemotherapeutic agent with potential nephrotoxicity. Delayed increase in serum creatinine after cisplatin administration shows that serum creatinine may not be a sufficient marker for early detection of nephrotoxicity. Urinary insulin-like growth factor binding protein-7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2) which are cell-cycle arrest biomarkers have been proposed recently for early detection of acute kidney injury (AKI). Herein, we evaluated urinary TIMP-2/IGFBP7 levels before and after cisplatin administration to patients with lung cancer and their role was examined in the early diagnosis of AKI...
March 2, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28255226/ahmed-glaucoma-valve-implant-surgical-technique-and-complications
#11
REVIEW
Ivano Riva, Gloria Roberti, Francesco Oddone, Anastasios Gp Konstas, Luciano Quaranta
Implantation of Ahmed glaucoma valve is an effective surgical technique to reduce intraocular pressure in patients affected with glaucoma. While in the past, the use of this device was reserved to glaucoma refractory to multiple filtration surgical procedures, up-to-date mounting experience has encouraged its use also as a primary surgery for selected cases. Implantation of Ahmed glaucoma valve can be challenging for the surgeon, especially in patients who already underwent previous multiple surgeries. Several tips have to be acquired by the surgeon, and a long learning curve is always needed...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28248709/intraoperative-hypotension-and-change-in-estimated-glomerular-filtration-rate-after-major-abdominal-surgery-a-prospective-observational-study
#12
Thijs C D Rettig, Erik Vermeulen, Ineke M Dijkstra, Wilton A van Klei, Ewoudt M W van de Garde, Linda M Peelen, Peter G Noordzij
No abstract text is available yet for this article.
April 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28244295/safety-of-using-matrix-metalloproteinase-inhibitor-in-experimental-glaucoma-filtration-surgery
#13
Wool Suh, Kyung Eun Han, Jae Ryong Han
We evaluated the safety of matrix metalloproteinase (MMP) inhibitor in experimental glaucoma filtration surgery in an animal model. Fifteen New Zealand white rabbits underwent an experimental trabeculectomy and were randomly allocated into 3 groups according to the adjuvant agent: no treatment group (n = 5), 0.02% mitomycin C (MMC) soaking group (n = 5), and MMP inhibitor (ilomastat) subconjunctival injection group (n = 5). Slit lamp examination with Seidel testing, pachymetry, and specular microscopy was performed preoperatively and postoperatively...
April 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28243862/preoperative-exercise-capacity-is-associated-with-the-prevalence-of-postoperative-delirium-in-elective-cardiac-surgery
#14
Masato Ogawa, Kazuhiro P Izawa, Seimi Satomi-Kobayashi, Aki Kitamura, Yasunori Tsuboi, Kodai Komaki, Rei Ono, Yoshitada Sakai, Hiroshi Tanaka, Yutaka Okita
BACKGROUND: Postoperative delirium (POD) is a critical complication that is closely associated with mortality and major morbidity in elective cardiac surgery. The identification of patients at risk for POD is crucial but has not been fully explored. AIMS: The aim of this study was to determine the predictive value of the assessment of preoperative exercise capacity for POD. METHODS: We enrolled 313 consecutive patients (mean age, 68.6 ± 14...
February 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28216932/role-of-calculated-glomerular-filtration-rate-using-percutaneous-nephrostomy-creatinine-clearance-in-the-era-of-radionuclide-scintigraphy
#15
Sunil Raghunath Patil, Prakash Wamanrao Pawar, Abhishek Jaysukhbhai Savalia, Shankar Tanaji Mundhe, Sayalee Suryabhan Narwade, Ashwin Sunil Tamhankar
CONTEXT: Gates method tends to over-estimate glomerular filtration rate (GFR) in borderline functioning kidneys. We study the role of calculated GFR in these cases in decision-making regarding performing kidney-sparing surgery or nephrectomy. AIMS: The aim of this study is to find the correlation between GFR calculated by percutaneous nephrostomy (PCN) urine creatinine clearance in obstructed kidneys and GFR by radionuclide scintigraphy. It also studies the role of this calculated GFR in borderline functioning kidneys...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28188362/comparing-renal-function-preservation-after-laparoscopic-radio-frequency-ablation-assisted-tumor-enucleation-and-laparoscopic-partial-nephrectomy-for-clinical-t1a-renal-tumor-using-a-3d-parenchyma-measurement-system
#16
Liangsong Zhu, Guangyu Wu, Jiwei Huang, Jianfeng Wang, Ruiyun Zhang, Wen Kong, Wei Xue, Yiran Huang, Yonghui Chen, Jin Zhang
PURPOSE: To compare the renal function preservation between laparoscopic radio frequency ablation assisted tumor enucleation and laparoscopic partial nephrectomy. METHODS: Data were analyzed from 246 patients who underwent laparoscopic radio frequency ablation assisted tumor enucleation and laparoscopic partial nephrectomy for solitary cT1a renal cell carcinoma from January 2013 to July 2015. To reduce the intergroup difference, we used a 1:1 propensity matching analysis...
February 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28183419/acute-kidney-injury-in-patients-continued-on-renin-angiotensin-system-blockers-during-hospitalization
#17
Numan Alabdan, Elvira O Gosmanova, Nhu Quynh T Tran, Carrie S Oliphant, Hu Pan, Joyce E Broyles, Joanna Q Hudson
BACKGROUND: Acute kidney injury (AKI) is common in hospitalized patients and is associated with adverse outcomes. This study aimed to evaluate patient characteristics and interventions during hospitalization associated with the development of AKI in patients continued on renin-angiotensin system (RAS) blockers during hospitalization. METHODS: A retrospective study of 184 adult patients admitted between January 2012 and September 2014 and continued on RAS blockers was conducted...
February 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28176949/prophylactic-furosemide-infusion-decreasing-early-major-postoperative-renal-dysfunction-in-on-pump-adult-cardiac-surgery-a-randomized-clinical-trial
#18
Solmaz Fakhari, Fariba Mirzaei Bavil, Eissa Bilehjani, Sona Abolhasani, Moussa Mirinazhad, Bahman Naghipour
INTRODUCTION: Acute renal dysfunction is a common complication of cardiac surgery. Furosemide is used in prevention, or treatment, of acute renal dysfunction. This study was conducted to evaluate the protective effects of intra- and early postoperative furosemide infusion on preventing acute renal dysfunction in elective adult cardiac surgery. METHODS: Eighty-one patients, candidates of elective cardiac surgery, were enrolled in this study in either the furosemide (n=41) or placebo (n=40) group...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28168047/suppression-of-human-tenon-fibroblast-cell-proliferation-by-lentivirus-mediated-vegf-small-hairpin-rna
#19
Zhongqiu Li, Wen Hua, Xuedong Li, Wei Wang
Purpose. The functions of vascular endothelial growth factor (VEGF) in scar formation after trabeculectomy were investigated in a human Tenon fibroblast cell line from glaucoma patients using lentivirus-mediated VEGF shRNA. Methods. Human Tenon fibroblast (HTF) cells were isolated from scar tissue of glaucoma patients during secondary surgery. Lentivirus-VEGF-shRNA was constructed and transfected into HTF cells. Subsequently, VEGF mRNA and protein expression were analyzed using quantitative RT-PCR and western blotting, respectively, and the effects of VEGF knockdown were analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28166753/aortic-calcification-burden-predicts-deterioration-of-renal-function-after-radical-nephrectomy
#20
Ken Fukushi, Shingo Hatakeyama, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Osamu Soma, Teppei Matsumoto, Itsuto Hamano, Takuma Narita, Atsushi Imai, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Yuriko Terayama, Tomihisa Funyu, Chikara Ohyama
BACKGROUND: Radical nephrectomy for renal cell carcinoma (RCC) is a risk factor for the development of chronic kidney disease (CKD), and the possibility of postoperative deterioration of renal function must be considered before surgery. We investigated the contribution of the aortic calcification index (ACI) to the prediction of deterioration of renal function in patients undergoing radical nephrectomy. METHODS: Between January 1995 and December 2012, we performed 511 consecutive radical nephrectomies for patients with RCC...
February 6, 2017: BMC Urology
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