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https://www.readbyqxmd.com/read/28188362/comparing-renal-function-preservation-after-laparoscopic-radio-frequency-ablation-assisted-tumor-enucleation-and-laparoscopic-partial-nephrectomy-for-clinical-t1a-renal-tumor-using-a-3d-parenchyma-measurement-system
#1
Liangsong Zhu, Guangyu Wu, Jiwei Huang, Jianfeng Wang, Ruiyun Zhang, Wen Kong, Wei Xue, Yiran Huang, Yonghui Chen, Jin Zhang
PURPOSE: To compare the renal function preservation between laparoscopic radio frequency ablation assisted tumor enucleation and laparoscopic partial nephrectomy. METHODS: Data were analyzed from 246 patients who underwent laparoscopic radio frequency ablation assisted tumor enucleation and laparoscopic partial nephrectomy for solitary cT1a renal cell carcinoma from January 2013 to July 2015. To reduce the intergroup difference, we used a 1:1 propensity matching analysis...
February 10, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28183419/acute-kidney-injury-in-patients-continued-on-renin-angiotensin-system-blockers-during-hospitalization
#2
Numan Alabdan, Elvira O Gosmanova, Nhu Quynh T Tran, Carrie S Oliphant, Hu Pan, Joyce E Broyles, Joanna Q Hudson
BACKGROUND: Acute kidney injury (AKI) is common in hospitalized patients and is associated with adverse outcomes. This study aimed to evaluate patient characteristics and interventions during hospitalization associated with the development of AKI in patients continued on renin-angiotensin system (RAS) blockers during hospitalization. METHODS: A retrospective study of 184 adult patients admitted between January 2012 and September 2014 and continued on RAS blockers was conducted...
February 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28176949/prophylactic-furosemide-infusion-decreasing-early-major-postoperative-renal-dysfunction-in-on-pump-adult-cardiac-surgery-a-randomized-clinical-trial
#3
Solmaz Fakhari, Fariba Mirzaei Bavil, Eissa Bilehjani, Sona Abolhasani, Moussa Mirinazhad, Bahman Naghipour
INTRODUCTION: Acute renal dysfunction is a common complication of cardiac surgery. Furosemide is used in prevention, or treatment, of acute renal dysfunction. This study was conducted to evaluate the protective effects of intra- and early postoperative furosemide infusion on preventing acute renal dysfunction in elective adult cardiac surgery. METHODS: Eighty-one patients, candidates of elective cardiac surgery, were enrolled in this study in either the furosemide (n=41) or placebo (n=40) group...
2017: Research and Reports in Urology
https://www.readbyqxmd.com/read/28168047/suppression-of-human-tenon-fibroblast-cell-proliferation-by-lentivirus-mediated-vegf-small-hairpin-rna
#4
Zhongqiu Li, Wen Hua, Xuedong Li, Wei Wang
Purpose. The functions of vascular endothelial growth factor (VEGF) in scar formation after trabeculectomy were investigated in a human Tenon fibroblast cell line from glaucoma patients using lentivirus-mediated VEGF shRNA. Methods. Human Tenon fibroblast (HTF) cells were isolated from scar tissue of glaucoma patients during secondary surgery. Lentivirus-VEGF-shRNA was constructed and transfected into HTF cells. Subsequently, VEGF mRNA and protein expression were analyzed using quantitative RT-PCR and western blotting, respectively, and the effects of VEGF knockdown were analyzed...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/28166753/aortic-calcification-burden-predicts-deterioration-of-renal-function-after-radical-nephrectomy
#5
Ken Fukushi, Shingo Hatakeyama, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Osamu Soma, Teppei Matsumoto, Itsuto Hamano, Takuma Narita, Atsushi Imai, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Yuriko Terayama, Tomihisa Funyu, Chikara Ohyama
BACKGROUND: Radical nephrectomy for renal cell carcinoma (RCC) is a risk factor for the development of chronic kidney disease (CKD), and the possibility of postoperative deterioration of renal function must be considered before surgery. We investigated the contribution of the aortic calcification index (ACI) to the prediction of deterioration of renal function in patients undergoing radical nephrectomy. METHODS: Between January 1995 and December 2012, we performed 511 consecutive radical nephrectomies for patients with RCC...
February 6, 2017: BMC Urology
https://www.readbyqxmd.com/read/28161843/validation-of-3d-volumetric-based-renal-function-prediction-calculator-for-nephron-sparing-surgery
#6
Renato Corradi, Aashish Kabra, Melissa Suarez, Jacob Oppenheimer, Zhamshid Okhunov, Hugh White, Stephanie Nougaret, Hebert A Vargas, Jaime Landman, Jonathan Coleman, Michael A Liss
OBJECTIVE: To evaluate a recently published volume-based renal function prediction calculator intended to be used in small renal mass surgical counseling. METHODS: Retrospective data collection included three-dimensional calculation of renal mass and parenchyma of patients who have undergone extirpative therapy. The predicted glomerular filtration rate (GFR) was calculated using the online calculator. The predicted GFR was compared with the actual 6-month GFR. The Pearson correlation coefficient, paired t test and root-mean-square error (RMSE) are utilized for statistical analysis...
February 4, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28161263/the-measured-glomerular-filtration-rate-mgfr-before-and-6%C3%A2-months-after-bariatric-surgery-a-pilot-study
#7
Maëva Clerte, Sandra Wagner, Claire Carette, Albane Brodin-Sartorius, Éve Vilaine, Jean-Claude Alvarez, Emuri Abe, Charles Barsamian, Sébastien Czernichow, Ziad A Massy
INTRODUCTION: Over the last few decades, the prevalence of obesity has increased dramatically. This increase has been mirrored by a rise in the risk of a number of health conditions, including hypertension, diabetes and chronic kidney disease. Although the weight loss following bariatric surgery has been shown to relieve the severity of diabetes and reduce hypertension, the effect on renal function has been less extensively evaluated. OBJECTIVE: The aims of the present study were to: (i) compare the estimated glomerular filtration rate (eGFR, using the MDRD and CKD-EPI equations) and the calculated glomerular filtration rate (using the 24-hour urine volume) with the measured glomerular filtration rate (mGFR) assessed with the plasma iohexol clearance method in severely obese patients, and (ii) evaluate the effect of weight loss on the mGFR 6 months after bariatric surgery...
February 1, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/28159494/compensatory-structural-and-functional-adaptation-after-radical-nephrectomy-for-renal-cell-carcinoma-according-to-preoperative-stage-of-chronic-kidney-disease-choi-dk-jung-sb-park-bh-jeong-bc-seo-si-jeon-ss-lee-hm-choi-hy-jeon-hg-j-urol-2015-oct-194-4-910-5
#8
Raman Jay, S B Jung, B H Park, B C Jeong, S I Seo, S S Jeon, H M Lee, H Y Choi, H G Jeon
PURPOSE: We investigated structural hypertrophy and functional hyperfiltration as compensatory adaptations after radical nephrectomy in patients with renal cell carcinoma according to the preoperative chronic kidney disease stage. MATERIALS AND METHODS: We retrospectively identified 543 patients who underwent radical nephrectomy for renal cell carcinoma between 1997 and 2012. Patients were classified according to preoperative glomerular filtration rate as no chronic kidney disease-glomerular filtration rate 90ml/min/1...
March 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28157649/prograf-produces-more-benefits-for-cyp3a5-low-expression-patients-in-early-stage-after-kidney-transplantation
#9
Bohan Fan, Kui Qiu, Yihang Jiang, Xiaopeng Hu, Hang Yin, Wei Wang, Liang Ren, Hang Liu, Wei Wang, Xiaodong Zhang
OBJECTIVE: This study is to analyze concentration changes of the prolonged-release and shorter-acting formulation of tacrolimus in patients with different CYP3A5 genotypes after kidney transplantation. METHODS: A single-factor retrospective analysis was performed in patients underwent allogeneic kidney transplantation with postoperative administration of Advagraf or Prograf in our hospital from May 2013 to June 2014. The CYP3A5 genotypes were determined, and tacrolimus trough concentrations in whole blood were measured within 28days after transplantation...
January 31, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28142133/perioperative-hemodynamic-instability-and-fluid-overload-are-associated-with-increasing-acute-kidney-injury-severity-and-worse-outcome-after-cardiac-surgery
#10
Anja Haase-Fielitz, Michael Haase, Rinaldo Bellomo, Paolo Calzavacca, Anke Spura, Hassina Baraki, Ingo Kutschka, Christian Albert
PURPOSE: The study aimed to investigate patients' characteristics, fluid and hemodynamic management, and outcomes according to the severity of cardiac surgery-associated acute kidney injury (CSA-AKI). METHODS: In a single-center, prospective cohort study, we enrolled 282 adult cardiac surgical patients. In a secondary analysis, we assessed preoperative patients' characteristics, physiological variables, and medication for intra- and postoperative fluid and hemodynamic management and outcomes according to CSA-AKI stages by the Renal risk, Injury, Failure, Loss, End-stage renal disease (RIFLE) classification...
January 31, 2017: Blood Purification
https://www.readbyqxmd.com/read/28124281/a-single-centre-experience-of-zero-ischaemia-laparoscopic-partial-nephrectomy-in-ireland
#11
C Browne, P E Lonergan, E M Bolton, F D'Arcy, T H Lynch
BACKGROUND: Nephron-sparing surgery in the form of partial nephrectomy is increasingly becoming the standard of care in patients with small renal tumours. Oncological outcomes for partial nephrectomy are equivalent to radical nephrectomy, however, clamping of the hilar vessels to allow resection of tumours during partial nephrectomy may cause ischaemic damage to the kidney and result in long-term renal impairment. AIM: We carried out a retrospective review of 43 patients undergoing laparoscopic partial nephrectomy (LPN) and assessed functional and oncological outcomes...
January 25, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28119865/predictors-of-morbidity-and-mortality-after-surgery-for-intestinal-perforation
#12
Rumi Shin, Sang Mok Lee, Beonghoon Sohn, Dong Woon Lee, Inho Song, Young Jun Chai, Hae Won Lee, Hye Seong Ahn, In Mok Jung, Jung Kee Chung, Seung Chul Heo
PURPOSE: An intestinal perforation is a rare condition, but has a high mortality rate, even after immediate surgical intervention. The clinical predictors of postoperative morbidity and mortality are still not well established, so this study attempted to identify risk factors for postoperative morbidity and mortality after surgery for an intestinal perforation. METHODS: We retrospectively analyzed the cases of 117 patients who underwent surgery for an intestinal perforation at a single institution in Korea from November 2008 to June 2014...
December 2016: Annals of Coloproctology
https://www.readbyqxmd.com/read/28114196/early-gains-in-renal-function-following-implantation-of-heartmate-ii-left-ventricular-assist-devices-may-not-persist-to-one-year
#13
Tal Hasin, Avishay Grupper, John J Dillon, Joseph J Maleszewski, Zhuo Li, Yan Topilsky, Robert P Frantz, Brooks S Edwards, Naveen L Pereira, Simon Maltais, John M Stulak, Lyle Joyce, Richard Daly, Soon J Park, Sudhir S Kushwaha
Renal function improves early after left ventricular assist device (LVAD) implantation but later decline has been observed. We sought to determine the occurrence and evaluate possible causes for this decline. In 62 consecutive patients with HeartMateII LVAD with available calculated glomerular filtration rate (GFR, ml/min/1.73m) one year after implant, GFR was assessed repeatedly and possible predictors for decline from 3 to 12 months were investigated. Post-mortem renal specimens for patients supported with an LVAD were evaluated...
January 19, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28102538/comparing-early-liver-graft-function-from-heart-beating-and-living-donors-a-pilot-study-aiming-to-identify-new-biomarkers-of-liver-injury
#14
Qi Joy Yang, Michael Kluger, Krzysztof Goryński, Janusz Pawliszyn, Barbara Bojko, Ai-Ming Yu, Keumhan Noh, Markus Selzner, Angela Jerath, Stuart McCluskey, K Sandy Pang, Marcin Wąsowicz
: Liver and kidney functions among recipients of liver transplantation (LT) surgery with heart beating (HBD, n = 13) or living donors (LD, n = 9) with different cold ischemic times were examined during the neohepatic phase for clearing rocuronium bromide (ROC, cleared by liver and kidney) and tranexamic acid (TXA, cleared by kidney). Solid phase micro-extraction and LC-MS/MS was applied to determine the plasma concentrations of ROC and TXA, and creatinine was determined by standard laboratory methods...
January 19, 2017: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/28101451/laparoscopic-vs-open-donor-nephrectomy-lessons-learnt-from-single-academic-center-experience
#15
Georgios Tsoulfas, Polyxeni Agorastou, Dicken S C Ko, Martin Hertl, Nahel Elias, A B Cosimi, Tatsuo Kawai
AIM: To compare laparoscopic and open living donor nephrectomy, based on the results from a single center during a decade. METHODS: This is a retrospective review of all living donor nephrectomies performed at the Massachusetts General Hospital, Harvard Medical School, Boston, between 1/1998 - 12/2009. Overall there were 490 living donors, with 279 undergoing laparoscopic living donor nephrectomy (LLDN) and 211 undergoing open donor nephrectomy (OLDN). Demographic data, operating room time, the effect of the learning curve, the number of conversions from laparoscopic to open surgery, donor preoperative glomerular filtration rate and creatinine (Cr), donor and recipient postoperative Cr, delayed graft function and donor complications were analyzed...
January 6, 2017: World Journal of Nephrology
https://www.readbyqxmd.com/read/28099405/insights-in-transplanting-complex-paediatric-renal-recipients-with-vascular-anomalies
#16
Pankaj Chandak, Nicos Kessaris, Chris J Callaghan, Francis Calder, Jelena Stojanovic, Jonathon Olsburgh, Martin Drage, Helen Hume-Smith, Zubir Ahmed, Anna Adamusiak, Derek Roebuck, Colin Forman, Stephen D Marks, Nizam Mamode
BACKGROUND: Children with end-stage kidney disease may have co-existing iatrogenic or congenital vascular anomalies making transplantation difficult. We describe our approach in 5 recipients with vascular anomalies and significant co-morbidities, including one case of blood group incompatibility. METHODS: Five children aged 3 - 17 (median 7) years, weighing 14 - 34 (median 18) kg of whom 4 had occluded inferior vena cava or iliac veins and 2 had previous complex vascular reconstructions prior to transplantation for mid-aortic syndrome and multiple aortic aneurysms, respectively underwent renal transplantation...
January 17, 2017: Transplantation
https://www.readbyqxmd.com/read/28098067/renal-function-in-type-2-diabetes-following-gastric-bypass
#17
Adrian T Billeter, Stefan Kopf, Martin Zeier, Katharina Scheurlen, Lars Fischer, Thilo M Schulte, Hannes G Kenngott, Barbara Israel, Philipp Knefeli, Markus W Büchler, Peter P Nawroth, Beat P Müller-Stich
BACKGROUND: Metabolic surgery for obese patients with type 2 diabetes (T2D) yields short- and long-term remission rates of 60-90%. Its effects on diabetesassociated complications such as neuropathy and nephropathy have not been well studied to date. Hardly any data are available on this subject with respect to moderately obese patients (body mass index [BMI] 25-35 kg/m2) with insulin-dependent T2D. Our previous studies suggest that, in such patients, treatment with a Roux-en-Y gastric bypass (RYGB) improves diabetic neuropathy...
December 9, 2016: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28093632/ureterocystoneostomy-in-complex-oncological-cases-with-an-uebelhoer-modified-boari-bladder-flap
#18
Jan P Radtke, Nina Korzeniewski, Johannes Huber, Celine D Alt, Sascha Pahernik, Boris A Hadaschik, Markus Hohenfellner, Dogu Teber
PURPOSE: The study aims to describe the technique and analyze the outcome of an arcuated bladder incision with building of a triangular flap, first described by Uebelhoer (UBBF), as a modification of the classical rectangular Boari bladder flap (BBF), that is often viable, but can present difficulties, such as reduced flap vascularization and mobility in pretreated patients. METHODS: Twelve consecutive patients with distal or mid ureteral leakage or stenosis, that underwent UBBF, were retrospectively analyzed...
January 16, 2017: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/28089737/browplasminin-a-condensed-tannin-with-anti-plasmin-activity-isolated-from-an-aqueous-extract-of-brownea-grandiceps-jacq-flowers
#19
Betzabeth Pereira, Josmary Brazón, Mónica Rincón, Eva Vonasek
ETHNOPHARMACOLOGICAL RELEVANCE: Following Venezuelan traditional medicine, females with heavy menstrual blood loss (menorrhagia) drink Brownea grandiceps Jacq. flowers (BG) decoctions to reduce the bleeding. In a previous study, we demonstrated that BG aqueous extract (E) possesses a potent anti-fibrinolytic activity capable of inhibiting plasmin, the main serine-protease that degrades fibrin. It is widely known that plasmin inhibitors are often used as anti-fibrinolytics to reduce bleeding during surgeries with high risk of blood loss such as cardiac, liver, vascular, tooth extraction and large orthopedic procedures, as well as for menorrhagia treatments...
January 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28088523/the-selective-cysteinyl-leukotriene-receptor-1-cyslt1r-antagonist-montelukast-regulates-extracellular-matrix-remodeling
#20
Jingli Peng, Hezheng Zhou, Guoping Kuang, Lilian Xie, Tao Tian, Ru Liu
Scar formation after filtration surgery of glaucoma is mainly caused by excessive synthesis of new extracellular matrix (ECM) and contraction of subconjunctival tissue mediated by human Tenon fibroblasts (HTFs) and the transforming growth factor (TGF-β1). Montelukast, a potent and specific cysteinyl leukotriene receptor 1 (cysLT1R) antagonist, is a licensed drug clinically used for the treatment of bronchial asthma. In this study, we investigated the effects of montelukast on the contractility of HTFs cultured in a three-dimensional collagen gel...
March 11, 2017: Biochemical and Biophysical Research Communications
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