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https://www.readbyqxmd.com/read/29777984/lc-ms-analysis-to-determine-the-biodistribution-of-a-polymer-coated-ilomastat-ocular-implant
#1
Abeer H A Mohamed-Ahmed, Alastair Lockwood, Hala Fadda, Shivam Madaan, Peng T Khaw, Steve Brocchini, Kersti Karu
Ilomastat is a matrix metalloproteinase inhibitor (MMPi) that has shown the potential to inhibit scarring (fibrosis) by mediating healing after injury or surgery. A long lasting ocular implantable pharmaceutical formulation of ilomastat is being developed to mediate the healing process to prevent scarring after glaucoma filtration surgery. The ilomastat implant was coated with water permeable and biocompatible phosphoryl choline polymer (PC1059) displayed extended slow release of ilomastat in vitro and in vivo...
May 16, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29771328/association-of-preoperative-plasma-fibrinogen-level-with-postoperative-bleeding-after-on-pump-coronary-bypass-surgery-does-plasma-fibrinogen-level-affect-the-amount-of-postoperative-bleeding
#2
Sameh Alagha, Murat Songur, Tugba Avci, Kerem Vural, Sadi Kaplan
OBJECTIVES: Our primary aim was to investigate the association between the preoperative concentration of plasma fibrinogen and the volume of postoperative bleeding. Our secondary aim was to identify whether there is a possible correlation between the patients' different characteristics and haemostatic laboratory variables and the postoperative amount of bleeding after on-pump coronary artery bypass grafting procedures. METHODS: A total of 550 adult patients undergoing isolated coronary artery bypass grafting on cardiopulmonary bypass in our hospital were enrolled and investigated retrospectively...
May 15, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29770263/evaluation-of-quantitative-and-qualitative-renal-outcome-following-nephron-sparing-surgery
#3
Gautam Ram Choudhary, Arup Kumar Mandal, Uttam Mete, Ravimohan Mavuduru, Anish Bhatacharia, Anupam Lal, Suresh Goyal
Purpose: Preservation of renal function after nephron-sparing surgery (NSS) is multifactorial and the impact of individual factors on it is still a debate. This prospective study investigates the impact of factors responsible for quantitative and functional outcome after NSS. Patients and Methods: Fifty-two patients of localized renal mass (≤7 cm) were included in the study. A contrast-enhanced computed tomography abdomen was performed for characterization of tumor...
2018: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/29768132/post-operative-infections-among-patients-undergoing-radical-cystectomy-at-a-tertiary-center
#4
Krystian Kaczmarek, Artur Lemiński, Aleksandra Bańcarz, Alicja Zakrzewska, Marcin Słojewski
BACKGROUND: Post-operative infection after radical cystectomy is a common complication. It is essential to identify modifiable risk factors that can predict post-operative infection to reduce the incidence of infection after radical cystectomy. We investigated the incidence of post-operative infection, associated pathogens, and risk factors for post-operative infection after radical cystectomy. PATIENTS AND METHODS: Patients who underwent radical cystectomy for bladder cancer in a single urologic department from 2014 to 2016 were included...
May 2018: Surgical Infections
https://www.readbyqxmd.com/read/29767556/hydronephrosis-is-associated-with-elevated-plasmin-in-urine-in-pediatric-patients-and-rats-and-changes-in-ncc-and-%C3%AE-enac-abundance-in-rat-kidney
#5
Rikke Zachar, Ammar Al-Mashhadi, Henrik Dimke, Per Svenningsen, Boye L Jensen, Mattias Carlström
Obstruction of urine flow at the level of the pelvo-ureteric junction (UPJO) and subsequent development of hydronephrosis is one of the most common congenital renal malformations. UPJO is associated with development of salt-sensitive hypertension, which is set by the obstructed kidney, and with a stimulated renin-angiotensin-aldosterone system (RAAS) in rodent models. This study aimed at investigating the hypothesis that i) in pediatric patients with UPJO the RAAS is activated prior to surgical relief of the obstruction; ii) in rats with UPJO the RAAS activation is reflected by increased abundance of renal aldosterone-stimulated Na+ transporters; and iii) the injured UPJO kidney allows aberrant filtration of plasminogen leading to proteolytic activation of the epithelial sodium channel gamma subunit (γ-ENaC)...
May 16, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29763932/microvesicles-from-human-adipose-tissue-derived-mesenchymal-stem-cells-as-a-new-protective-strategy-in-osteoarthritic-chondrocytes
#6
Miguel Tofiño-Vian, Maria Isabel Guillén, María Dolores Pérez Del Caz, Antonio Silvestre, María José Alcaraz
BACKGROUND/AIMS: Chronic inflammation contributes to cartilage degeneration during the progression of osteoarthritis (OA). Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. In the present work, we have isolated and characterized the extracellular vesicles from human AD-MSC to investigate their role in the chondroprotective actions of these cells. METHODS: AD-MSC were isolated by collagenase treatment from adipose tissue from healthy individuals subjected to abdominal lipectomy surgery...
May 9, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29761689/percutaneous-nephrolithotomy-in-solitary-kidneys-effective-safe-and-improves-renal-functions
#7
Volkan Caglayan, Sedat Oner, Efe Onen, Sinan Avci, Murat Aydos, Metin Kilic, Murat Demirbas
BACKGROUND: To evaluate success and complication rates of endourological stone treatments and to evaluate effects of percutaneous nephrolithotomy (PCNL) on renal functions, in patients with solitary kidneys. METHODS: In our center, 3150 patients underwent PCNL between 2003 and 2017 and 142 patients underwent retrograd intrarenal surgery (RIRS) between 2013 and 2017. We retrospectively analysed the data of 82 patients with solitary kidney who underwent PCNL and of 8 patients with solitary kidney who underwent RIRS...
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29753505/off-pump-technique-reduces-surgical-mortality-after-elective-coronary-artery-bypass-grafting-in-patients-with-preoperative-renal-failure
#8
Chikara Ueki, Hiroaki Miyata, Noboru Motomura, Ryuzo Sakata, Genichi Sakaguchi, Takehide Akimoto, Shinichi Takamoto
OBJECTIVES: Most randomized controlled trials of off-pump versus on-pump coronary artery bypass grafting (CABG) have included limited numbers of patients with preoperative renal failure. This study was performed to evaluate the association between the clinical benefit of the off-pump technique and chronic kidney disease stage. METHODS: We analyzed 38,051 patients with chronic kidney disease who underwent primary nonemergent isolated CABG from 2013 to 2015 as reported in the Japan Cardiovascular Surgery Database-Adult section...
April 12, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29750009/xen-glaucoma-treatment-system-in-the-management-of-refractory-glaucomas-a-short-review-on-trial-data-and-potential-role-in-clinical-practice
#9
REVIEW
A De Gregorio, E Pedrotti, G Stevan, A Bertoncello, S Morselli
The recent development of new devices that are significantly less invasive, collectively termed minimally invasive glaucoma surgery, offers new perspective of intraocular pressure reduction with less risk, short operating times, and rapid recovery. The aim of this work is to provide a panoramic review of the currently published clinical data to assess the potential role of XEN gel stent (Allergan PLC, Irvine, CA, USA) in the management of glaucoma, which is the only filtering minimally invasive glaucoma surgery device that allows the subconjunctival filtration...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29733108/reliability-of-serum-creatinine-based-formulae-estimating-renal-function-in-non-critically-ill-surgery-patients-focus-on-augmented-renal-clearance
#10
Peter Declercq, Matthias Gijsen, Björn Meijers, Marie Schetz, Stefaan Nijs, André D'Hoore, Joost Wauters, Isabel Spriet
WHAT IS KNOWN AND OBJECTIVES: Formulae estimating glomerular filtration rate (GFR) are frequently used to guide drug dosing. The objectives of this prospective single-center study were to evaluate agreement between these equations and measured creatinine clearance (CrCl) in non-critically ill surgery patients with normal kidney function and augmented renal clearance (ARC, CrCl ≥ 130 mL/min/1.73 m²), to determine predictors for disagreement, define a GFR estimator cut-off value identifying ARC and determine the ARC prevalence and duration in non-critically ill surgical patients...
May 7, 2018: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/29732207/oncological-and-functional-efficacy-of-nephron-sparing-surgery-versus-radical-nephrectomy-in-renal-cell-carcinoma-stages-%C3%A2-ct1b-a-single-institution-matched-analysis
#11
Ralf Veys, Firas Abdollah, Alberto Briganti, Maarten Albersen, Hein Van Poppel, Steven Joniau
Introduction: The purpose of this paper is to compare oncological outcomes of partial nephrectomy (PN) versus radical nephrectomy (RN) in renal cell carcinoma (RCC) clinical stages ≥T1b, in a retrospective propensity-score matched cohort of a high-volume, tertiary referral center. This paper also aims to compare renal function and complication rates between groups. Material and methods: Our single-institution RCC database was queried to select patients with clinical stages defined by tumor size (T), lymph nodes(N), and metastasis (M) scores of T1b-4 N0 M0, that underwent PN or RN between 2000 and 2014...
2018: Central European Journal of Urology
https://www.readbyqxmd.com/read/29731059/long-term-follow-up-of-living-kidney-donors-with-chronic-kidney-disease-at-1-year-after-nephrectomy
#12
J C Na, J S Park, M-G Yoon, H H Lee, Y E Yoon, K H Huh, Y S Kim, W K Han
BACKGROUND: Although renal function recovery of living kidney donors has been reported in a number of studies, many patients show poor recovery, and the long-term prognosis of these patients has not been well studied. In this investigation we explored the long-term prognosis of renal function in patients with chronic kidney disease (CKD) at 1 year after nephrectomy. METHODS: Patients who underwent donor nephrectomy during the period from March 2006 to April 2014, with a follow-up creatinine study at 1 year postoperatively and more than 3 years of follow-up, were included in the study...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29728307/outcome-measures-used-to-report-kidney-function-in-studies-investigating-surgical-management-of-kidney-tumours-a-systematic-review
#13
REVIEW
Robert J Ellis, Yeoungjee Cho, Sharon J Del Vecchio, Megan McStea, Christudas Morais, Jeff S Coombes, Simon T Wood, Glenda C Gobe, Ross S Francis
CONTEXT: Most practice decisions relevant to preserving kidney function in patients managed surgically for kidney tumours are driven by observational studies. A wide range of outcome measures are used in these studies, which reduces comparability and increases the risk of reporting bias. OBJECTIVE: To comprehensively and succinctly describe the outcomes used to evaluate kidney function in studies evaluating surgical management of kidney tumours. EVIDENCE ACQUISITION: Electronic search of the PubMed database was conducted to identify studies with at least one measure of kidney function in patients managed surgically for kidney tumours, published between January 2000 and September 2017...
May 1, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29726039/relationship-between-intraoperative-serum-lactate-and-hemoglobin-levels-on-postoperative-renal-function-in-patients-undergoing-elective-cardiac-surgery
#14
Steven C Mitchell, Anirudh Vinnakota, Salil V Deo, Alan H Markowitz, Basar Sareyyupoglu, Yakov Elgudin, Benjamin Medalion, Adam Tzagournis, Joseph Sabik, Soon J Park
BACKGROUND AND AIM: We examined the relationship between serum lactate and hemoglobin levels on renal function and postoperative outcome in low-risk elective coronary artery bypass graft (CABG) patients. METHODS: Intraoperative hemoglobin and lactate levels were measured in elective isolated CABG patients. Patients with renal dysfunction (baseline creatinine>2 mg/dL) were excluded. Multivariate logistic regression was used to determine associations between lactate, hemoglobin, and acute kidney injury (AKI)...
May 3, 2018: Journal of Cardiac Surgery
https://www.readbyqxmd.com/read/29719583/a-novel-macroscale-acoustic-device-for-blood-filtration
#15
Brian Dutra, Maria Carmen Mora, Tyler I Gerhardson, Brianna Sporbert, Alexandre Dufresne, Katharine R Bittner, Carolanne Lovewell, Michael J Rust, Michael V Tirabassi, Louis Masi, Bart Lipkens, Daniel R Kennedy
Retransfusion of a patient's own shed blood during cardiac surgery is attractive since it reduces the need for allogeneic transfusion, minimizes cost, and decreases transfusion related morbidity. Evidence suggests that lipid micro-emboli associated with the retransfusion of the shed blood are the predominant causes of the neurocognitive disorders. We have developed a novel acoustophoretic filtration system that can remove lipids from blood at clinically relevant flow rates. Unlike other acoustophoretic separation systems, this ultrasound technology works at the macroscale, and is therefore able to process larger flow rates than typical micro-electromechanical system (MEMS) scale acoustophoretic separation devices...
March 2018: Journal of Medical Devices
https://www.readbyqxmd.com/read/29718365/high-and-low-estimated-glomerular-filtration-rates-are-associated-with-adverse-outcomes-in-patients-undergoing-surgery-for-gastrointestinal-malignancies
#16
Takashi Ui, Yoshitsugu Obi, Akihiro Shimomura, Alan K Lefor, Reza Fazl Alizadeh, Hyder Said, Ninh T Nguyen, Michael J Stamos, Kamyar Kalantar-Zadeh, Naohiro Sata, Hirohito Ichii
Background: Abnormally high estimated glomerular filtration rates (eGFRs) are associated with endothelial dysfunction and frailty. Previous studies have shown that low eGFR is associated with increased morbidity, but few reports address high eGFR. The purpose of this study is to evaluate the association of high eGFR with surgical outcomes in patients undergoing surgery for gastrointestinal malignancies. Methods: We identified patients who underwent elective surgery for gastrointestinal malignancies from 2005 to 2015 in the American College of Surgeons National Surgical Quality Improvement Program database...
April 27, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29714043/vasomotion-as-an-oscillatory-sign-of-functional-impairment-in-the-human-internal-thoracic-artery-a-study-based-on-risk-factors-and-vessel-reactivity
#17
Diogo A Fonseca, Pedro E Antunes, Manuel J Antunes, Maria Dulce Cotrim
NEW FINDINGS: What is the central question of this study? Vasomotion has been viewed as a rhythmic oscillation of the vascular tone that is physiologically important for optimal tissue perfusion. Also, it has been primarily studied in the microcirculation. However, the precise underlying mechanisms and the physiological significance remain unknown. What is the main finding and its importance? Vasomotion is not specific of the microcirculation, as shown by our findings. In human arteries from patients undergoing cardiac surgery, an increased incidence was associated with endothelial dysfunction settings...
April 30, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29713141/risk-factors-for-requirement-of-filtration-surgery-after-vitrectomy-in-patients-with-proliferative-diabetic-retinopathy
#18
Masashi Sakamoto, Ryuya Hashimoto, Izumi Yoshida, Takatoshi Maeno
Purpose: We retrospectively reviewed patients with postoperative neovascular glaucoma (NVG) after vitrectomy for proliferative diabetic retinopathy to investigate how variables assessed before, during, and after vitrectomy are associated with the requirement for filtration surgery. Patients and methods: The subjects in this retrospective, observational, comparative study were 55 consecutive patients (61 eyes) who underwent vitrectomy for proliferative diabetic retinopathy at Toho University Sakura Medical Center between December 2011 and November 2016, were followed up for at least 6 months after surgery, and developed NVG within 2 years after surgery...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29708031/the-use-of-remowell-oxygenator-integrated-device-in-the-prevention-of-the-complications-related-to-aortic-valve-surgery-in-the-elderly-patient-preliminary-results
#19
Alberto Molardi, Maria V Di Chicco, Davide Carino, Matteo Goldoni, Matteo Ricci, Bruno Borrello, Florida Gripshi, Tiziano Gherli, Francesco Nicolini
Background The effects of fat microembolization due to cardiopulmonary bypass are well known in cardiac surgery. Our aim is to evaluate the use of the RemoweLL device (Eurosets, Medolla, Italy) during elective aortic valve replacement in elderly patients (>70 years old) to rate its biochemical and clinical effects. The RemoweLL device is an oxygenator-integrated reservoir which combines two strategies for fat emboli and leucocytes removal: filtration and supernatant elimination. Methods Forty-four elderly patients were enrolled and assigned randomly to a Group A (standard device) and a Group B (RemoweLL)...
June 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29697508/in-line-filtration-reduces-postoperative-venous-peripheral-phlebitis-associated-with-cannulation-a-randomized-clinical-trial
#20
Gianluca Villa, Cosimo Chelazzi, Rosa Giua, Lorenzo Tofani, Giovanni Zagli, Paolo Boninsegni, Fulvio Pinelli, A Raffaele De Gaudio, Stefano Romagnoli
BACKGROUND: Peripheral venous cannulation is an everyday practice of care for patients undergoing anesthesia and surgery. Particles infused with intravenous fluids (eg, plastic/glass/drugs particulate) contribute to the pathogenesis of peripheral phlebitis. The aim of this study is to demonstrate the efficacy of in-line filtration in reducing the incidence of postoperative phlebitis associated with peripheral short-term vascular access. METHODS: In this controlled trial, 268 surgical patients were randomly assigned to in-line filtration and standard care (NCT03193827)...
April 23, 2018: Anesthesia and Analgesia
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