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https://www.readbyqxmd.com/read/29331401/preoperative-dipstick-albuminuria-and-other-urine-abnormalities-predict-acute-kidney-injury-and-patient-outcomes
#1
Sehoon Park, Soojin Lee, Anna Lee, Jin Hyuk Paek, Ho Jun Chin, Ki Young Na, Dong-Wan Chae, Sejoong Kim
BACKGROUND: It is unclear whether pathologic findings on preoperative urinalysis are associated with the risk of postoperative acute kidney injury (AKI). Therefore, we performed a retrospective review to investigate this association. METHODS: We assessed the clinical significance of preoperative dipstick urinalysis in a 10-year surgery cohort from a tertiary hospital in Korea. Patients without available information on perioperative serum creatinine levels or kidney injury prior to surgery were excluded...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29331397/persistent-hyperparathyroidism-as-a-risk-factor-for-long-term-graft-failure-the-need-to-discuss-indication-for-parathyroidectomy
#2
Maria Júlia Correia Lima Nepomuceno Araujo, Janaina Almeida Mota Ramalho, Rosilene Motta Elias, Vanda Jorgetti, William Nahas, Melani Custodio, Rosa M A Moysés, Elias David-Neto
BACKGROUND: Although a successful kidney transplant (KTx) improves most of the mineral and bone disorders (MBD) produced by chronic kidney disease (CKD), hyperparathyroidism may persist (pHPT). Current guidelines recommend parathyroidectomy if serum parathormone is persistently elevated 1 year after KTx, because pHPT has been recently associated with poor graft outcomes. However, whether patients with pHPT and adequate renal function are at risk for long-term graft failure is unknown...
January 10, 2018: Surgery
https://www.readbyqxmd.com/read/29327032/three-dimensional-volumetric-analysis-of-3-fat-processing-techniques-for-facial-fat-grafting-a-randomized-clinical-trial
#3
Rongwei Wu, Xiaonan Yang, Xiaolei Jin, Haibin Lu, Zhenhua Jia, Binghang Li, Haiyue Jiang, Zuoliang Qi
Importance: Autologous fat grafting has revolutionized the field of facial soft-tissue augmentation, despite a lack of standardization. Objective data are needed to arrive at consensus regarding the best technique for optimal volume retention. Objective: To compare 3 fat-processing techniques with 3-dimensional (3-D) technology to explore the optimal fat-processing technique for improving the volume retention of grafted fat. Design, Setting, and Participants: From September 2015 to December 2016, patients with facial asymmetry were treated by initial facial fat grafting at the Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College...
January 11, 2018: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29326843/risk-of-acute-kidney-injury-in-patients-randomized-to-a-restrictive-versus-liberal-approach-to-red-blood-cell-transfusion-in-cardiac-surgery-a-substudy-protocol-of-the-transfusion-requirements-in-cardiac-surgery-iii-noninferiority-trial
#4
Amit X Garg, Nadine Shehata, Shay McGuinness, Richard Whitlock, Dean Fergusson, Ron Wald, Chirag Parikh, Sean M Bagshaw, Boris Khanykin, Alex Gregory, Summer Syed, Gregory M T Hare, Meaghan S Cuerden, Kevin E Thorpe, Judith Hall, Subodh Verma, Pavel S Roshanov, Jessica M Sontrop, C David Mazer
Background: When safe to do so, avoiding blood transfusions in cardiac surgery can avoid the risk of transfusion-related infections and other complications while protecting a scarce resource and reducing costs. This protocol describes a kidney substudy of the Transfusion Requirements in Cardiac Surgery III (TRICS-III) trial, a multinational noninferiority randomized controlled trial to determine whether the risk of major clinical outcomes in patients undergoing planned cardiac surgery with cardiopulmonary bypass is no greater with a restrictive versus liberal approach to red blood cell transfusion...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29325738/the-effect-of-patient-and-surgical-characteristics-on-renal-function-after-partial-nephrectomy
#5
Andrew G Winer, Emily C Zabor, Michael J Vacchio, A Ari Hakimi, Paul Russo, Jonathan A Coleman, Edgar A Jaimes
BACKGROUND: The purpose of the study was to identify patient and disease characteristics that have an adverse effect on renal function after partial nephrectomy. PATIENTS AND METHODS: We conducted a retrospective review of 387 patients who underwent partial nephrectomy for renal tumors between 2006 and 2014. A line plot with a locally weighted scatterplot smoothing was generated to visually assess renal function over time. Univariable and multivariable longitudinal regression analyses incorporated a random intercept and slope to evaluate the association between patient and disease characteristics with renal function after surgery...
December 6, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29303873/case-report-xen-ab-interno-gel-stent-use-in-a-refractory-glaucoma-patient-with-previous-filtration-surgeries
#6
Simrenjeet Sandhu, Michael W Dorey
This case study reports the successful implantation of the Xen ab interno gel stent in a 44-year-old male with refractory chronic open angle glaucoma. The patient had multiple unsuccessful filtration surgeries including a trabeculectomy and two Ahmed glaucoma valves placed superotemporally and inferonasally OD. The patients intraocular pressure was reduced from 29▒mm Hg preoperatively to 17▒mm Hg 1 year after surgery, without any ocular complications. The Xen gel stent may be considered as a possible intervention to lower IOP in patients with refractory glaucoma, despite previous filtration surgeries if the superonasal conjunctiva is spared and healthy...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29299887/is-the-homocysteine-level-a-good-predictive-marker-for-evaluating-kidney-function-in-patients-after-percutaneous-nephrolithotomy
#7
Ismail Karlidag, Deniz Abat, Adem Altunkol, Volkan Izol, Erkan Demir, Ibrahim Atilla Aridogan
PURPOSE: The purpose of this study is to evaluate the preoperative, early and late postoperative homocysteine levels and its relationship with kidney function in patients after undergoing percutaneous nephrolithotomy (PNL). MATERIALS AND METHODS: Twenty-three patients with kidney stones underwent PNL and blood samples were taken preoperatively as well as at 48 hours and three months after the operation. The homocysteine level was determined by high pressure liquid chromatography and the fluorometric method in blood samples with ethylenediaminetetraaceticacid...
January 4, 2018: Urology Journal
https://www.readbyqxmd.com/read/29286070/nppb-modulates-apoptosis-proliferation-migration-and-extracellular-matrix-synthesis-of-conjunctival-fibroblasts-by-inhibiting-pi3k-akt-signaling
#8
Lixia Sun, Yaru Dong, Jing Zhao, Yuan Yin, Bainan Tong, Yajuan Zheng, Hua Xin
When treating glaucoma, excessive scar tissue reactions reduce the postoperative survival rate of the filtering bleb. Accumulating evidence has demonstrated that the proliferation, migration and extracellular matrix (ECM) synthesis of fibroblasts are important molecular mechanisms underlying scar formation. Recent evidence has demonstrated that chloride channels play an important role in controlling cell proliferation, apoptosis, migration and the cell cycle process in several cell types, but the effects of chloride channels on conjunctival fibroblasts have not be studied...
December 15, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29285239/low-density-lipoprotein-rosiglitazone-chitosan-calcium-alginate-nanoparticles-inhibition-of-human-tenon-s-fibroblasts-activation-and-proliferation
#9
Yi Gong, Jia-Yang Yin, Bo-Ding Tong, Jie-Xi Zeng, Wei Xiong
Anti-fibrotic therapeutic methods with safety and efficiency after glaucoma filtration surgery (GFS) are desirable. In our previous study, by using Human Tenon's Fibroblasts (HTFs) as a model, we proved the expression of peroxisome proliferator activates receptor-γ (PPAR-γ) in HTFs; in addition, rosiglitazone (RSG), an agonist of PPAR-γ, can inhibit transforming growth factorsβ1 (TGF-β1)-induced reactivation of HTFs, thus to inhibit specifically scarring after GFS through intervening TGF-β/Smads signal pathway...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29285078/antiproliferative-effect-of-double-suicide-gene-delivery-mediated-by-polyamidoamine-dendrimers-in-human-tenon-s-capsule-fibroblasts
#10
Jin Yang, Liu Kun Shi, Hui Min Sun, Yan Ming Wang
The aim of the present study was to investigate the therapeutic potential of a double suicide gene, thymidine kinase (TK) combined with cytosine deaminase (CD), mediated by generation of 5-polyamidoamine dendrimers (G5-PAMAM-D) on human Tenon's capsule fibroblasts (HTFs) as an anti-scarring agent. The pAcGFP1-Hyg-TK-CD plasmid was transfected into HTFs, and reverse-transcription polymerase chain reaction (RT-PCR) was used to detect TK-CD expression. MTT cell proliferation assay was used to evaluate the cytotoxic effects of ganciclovir (GCV) and 5-flurocytosine (5-FC) on HTFs...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29284159/characteristics-and-clinical-outcomes-of-living-renal-donors-in-hong-kong
#11
Y L Hong, C H Yee, C B Leung, J Yc Teoh, B Ch Kwan, P Kt Li, S Sm Hou, C F Ng
INTRODUCTION: In Asia, few reports are available on the outcomes for living renal donors. We report the short- and long-term clinical outcomes of individuals following living donor nephrectomy in Hong Kong. METHODS: We retrospectively reviewed the characteristics and clinical outcomes of all living renal donors who underwent surgery from January 1990 to December 2015 at our centre in Hong Kong. Information was obtained from hospital records and territory-wide electronic patient records...
December 29, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29284123/conversion-of-robot-assisted-partial-nephrectomy-to-radical-nephrectomy-a-prospective-multi-institutional-study
#12
Sohrab Arora, Brian Chun, Rajesh K Ahlawat, Ronney Abaza, James Adshead, James R Porter, Benjamin Challacombe, Prokar Dasgupta, Giorgio Gandaglia, Daniel A Moon, T B Yuvaraja, Umberto Capitanio, Alessandro Larcher, Francesco Porpiglia, Alexander Mottrie, Mahendra Bhandari, Craig Rogers
OBJECTIVES: To assess the incidence, and factors affecting conversion from robot-assisted partial nephrectomy (RAPN) to radical nephrectomy. METHODS: Between November 2014 and February 2017, 501 patients underwent attempted RAPN by 22 surgeons at 14 centers in nine countries within the Vattikuti Collaborative Quality Initiative database. Patients were permanently logged for RAPN prior to surgery and were analysed on an intention-to-treat basis. Multivariable logistic regression with backward stepwise selection of variables was done to assess the factors associated with conversion to radical nephrectomy...
December 25, 2017: Urology
https://www.readbyqxmd.com/read/29274024/the-effect-of-trabeculectomy-on-contrast-sensitivity-corneal-topography-and-aberrations
#13
Fereshteh Abolbashari, Asieh Ehsaei, Ramin Daneshvar, Nasrin Moghaddas Sharif, Ahmad Gholami, Naeemeh Monfared, Seyed Mahdi Ahmadi Hosseini
PURPOSE: To investigate the effect of trabeculectomy on corneal topography, corneal sensitivity and aberrations. METHODS: Twenty-four eyes of 24 subjects with open-angle glaucoma who required glaucoma filtration surgery were assessed. The evaluation of corneal topography, corneal sensitivity and aberrations were done before the trabeculectomy procedure, 1 week and 1 month after the trabeculectomy. RESULTS: There were significant differences in cylindrical power (P = 0...
December 22, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29260635/comparison-of-two-indices-to-annotate-complications-after-radical-nephroureterectomy
#14
Rosa Park, Christopher Rjepaj, Kathleen Lehman, Jay D Raman
INTRODUCTION: The Clavien-Dindo (CD) and Comprehensive Complication Index (CCI) are two grading systems that annotate adverse events following surgical procedures. We compare these two classification systems in a cohort of patients undergoing radical nephroureterectomy (RNU). MATERIALS AND METHODS: The charts of 110 consecutive RNU patients were reviewed for complications occurring within 30 days of surgery. Grading by the CD classification system and values for CCI were calculated...
December 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29242028/blockade-of-kca3-1-a-novel-target-to-treat-tgf-%C3%AE-1-induced-conjunctival-fibrosis
#15
Govindaraj Anumanthan, Philip J Wilson, Ratnakar Tripathi, Nathan P Hesemann, Rajiv R Mohan
Postoperative conjunctival fibrosis is common in patients after glaucoma filtration surgery. The calcium activated potassium (KCa3.1) channel has been shown to inhibit fibrosis in many non-ocular tissues. However, its potential in treating ocular fibrosis remains unknown. We tested the anti-fibrotic potential of TRAM34, a selective blocker of KCa3.1 channel, in treating conjunctival fibrosis. Primary human conjunctival fibroblast (HCF) cultures derived from donor tissues. Myofibroblasts causing conjunctival fibrosis were generated by growing HCFs in the presence of TGFβ1 for 72 h...
December 11, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/29230572/responsiveness-of-internal-thoracic-arteries-to-nitroglycerin-in-patients-with-renal-failure
#16
Masashi Tawa, Takeshi Kinoshita, Tohru Asai, Tomoaki Suzuki, Takaharu Ishibashi, Tomio Okamura
Nitroglycerin is commonly used as an antispasmodic for treating spasm of coronary artery bypass grafts. This study investigated whether the presence of renal failure affects reactivity to nitroglycerin in internal thoracic arteries obtained from patients undergoing coronary bypass surgery. The patients were divided into three groups according to estimated glomerular filtration rate (eGFR, mL/min/1.73 m2): without renal failure (60 ≤ eGFR, n = 13), with moderate renal failure (30 ≤ eGFR < 60, n = 10), and with severe renal failure (eGFR < 30, n = 10)...
December 11, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/29226570/campath-calcineurin-inhibitor-reduction-and-chronic-allograft-nephropathy-the-3c-study-results-of-a-randomized-controlled-clinical-trial
#17
Richard Haynes, Lisa Blackwell, Natalie Staplin, William G Herrington, Jonathan Emberson, Parminder K Judge, Benjamin C Storey, Martin J Landray, Paul N Harden, Colin Baigent, Peter Friend
Calcineurin inhibitors (CNI e.g. tacrolimus) reduce short-term kidney transplant failure, but chronic nephrotoxicity may contribute to late transplant loss. Elective conversion to inhibitors of the mammalian target of rapamycin pathway (mTOR e.g. sirolimus) might avoid long-term CNI renal damage and improve outcomes. The 3C Study was a pragmatic randomized controlled trial comprising sequential randomizations between alemtuzumab and basiliximab induction therapy (at the time of surgery) and between tacrolimus and sirolimus maintenance therapy at 6-months post-transplant...
December 11, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29225814/perioperative-plasma-lyte-use-reduces-the-incidence-of-renal-replacement-therapy-and-hyperkalaemia-following-renal-transplantation-when-compared-with-0-9-saline-a-retrospective-cohort-study
#18
Anamika Adwaney, David W Randall, Mark J Blunden, John R Prowle, Christopher J Kirwan
Background: Kidney transplant recipients often receive large volumes of intravenous fluid replacement in the peri-operative period. Administration of 0.9% saline has previously been associated with acidosis, hyperkalaemia and acute kidney injury. The perioperative use of physiologically balanced replacement fluids may reduce the incidence of post-operative renal replacement therapy and hyperkalaemia. Methods: A retrospective review of consecutive renal transplants before and after a change in perioperative fluid prescription from 0...
December 2017: Clinical Kidney Journal
https://www.readbyqxmd.com/read/29222505/a-comparison-of-methods-to-measure-central-and-peripheral-oxytocin-concentrations-in-human-and-non-human-primates
#19
Arthur Lefevre, Raphaëlle Mottolese, Manon Dirheimer, Carmine Mottolese, Jean-René Duhamel, Angela Sirigu
Oxytocin (OT) concentration in the blood is considered to be a marker of its action in the brain. However, two problems have emerged when measuring OT level in the blood. First, it is unclear whether different methods of assessment lead to similar OT values. Second, it is unclear if plasma OT concentrations is informative on what OT does in the brain. To clarify these issues, we collected cerebrospinal fluid (CSF) from the brain ventricle of 25 patients during surgery to compare with plasma OT after simultaneous blood withdrawal...
December 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29207229/-bilirubin-removal-with-coupled-plasma-filtration-and-adsorption-in-patients-affected-by-hilar-cholangiocarcinoma
#20
Walter De Simone, Francesco Crafa, Adele Noviello, Francesco Esposito, Bruno Zito, Rocco Manganelli, Antonella De Simone, Luigi Covotta, Giuseppe Palladino, Emanuele De Simone
Background: Patients affected by hilar cholangiocarcinoma are eligible for surgery only in the 20-30% of the cases and postoperative mortality is 40-50%. Many specialists are involved in the treatment of this disease, like surgeons, gastroenterologists, oncologists and radiotherapists. Recent studies have shown that preoperative bilirubinaemia is a predictor of morbidity and mortality after surgery. Coupled Plasma Filtration and Adsorption (CPFA) is a blood purification extracorporeal therapy recommended for sepsis and able to reduce bilirubinaemia...
December 5, 2017: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
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