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Dirk W Donker, Christiaan L Meuwese, Sue A Braithwaite, Michael Broomé, Joris J van der Heijden, Jeannine A Hermens, Marc Platenkamp, Michel de Jong, Jacqueline G D Janssen, Martin Balík, Jan Bělohlávek
Extracorporeal life support (ECLS) is a mainstay of current practice in severe respiratory, circulatory or cardiac failure refractory to conventional management. The inherent complexity of different ECLS modes and their influence on the native pulmonary and cardiovascular system require patient-specific tailoring to optimize outcome. Echocardiography plays a key role throughout the ECLS care, including patient selection, adequate placement of cannulas, monitoring, weaning and follow-up after decannulation. For this purpose, echocardiographers require specific ECLS-related knowledge and skills, which are outlined here...
May 2018: Perfusion
Arden L Corter, Reuben Broom, David Porter, Vernon Harvey, Michael Findlay
BACKGROUND: Failing to take endocrine therapy (ET) as prescribed (nonadherence) increases risk of morbidity and mortality from breast cancer recurrence. We explored predictors of nonadherence, including demographic, clinical, treatment and personal factors, among women newly prescribed ET for early stage breast cancer. We also examined predictors of their thoughts about stopping treatment (TST). METHODS: A baseline survey prior to ET assessed demographics, illness beliefs, beliefs about medicines, fear of recurrence, symptoms and negative affect...
May 18, 2018: Psycho-oncology
Rebekah A Frampton, Sarah M Thompson, Falk Kalamorz, Charles David, Shea M Addison, Grant R Smith
Here, we report the draft genome sequence of " Candidatus Liberibacter europaeus" ASNZ1, assembled from broom psyllids ( Arytainilla spartiophila ) from New Zealand. The assembly comprises 15 contigs, with a total length of 1.33 Mb and a G+C content of 33.5%.
May 17, 2018: Genome Announcements
Stephen Weng, Joe Kai, Jennifer Tranter, Jo Leonardi-Bee, Nadeem Qureshi
BACKGROUND AND AIMS: Familial hypercholesterolaemia (FH) is a major cause of premature heart disease but remains unrecognised in most patients. This study investigated if a systematic primary care-based approach to identify and manage possible FH improves recommended best clinical practice. METHODS: Pre- and post-intervention study in six UK general practices (population 45,033), which invited patients with total cholesterol >7.5 mmol/L to be assessed for possible FH...
April 30, 2018: Atherosclerosis
S E Humphries, J A Cooper, M Seed, N Capps, P N Durrington, B Jones, I F W McDowell, H Soran, H A W Neil
BACKGROUND AND AIMS: Patients with familial hypercholesterolaemia (FH) have an elevated risk of coronary heart disease (CHD). Here we compare changes in CHD mortality in patients with heterozygous (FH) pre 1992, before lipid-lowering therapy with statins was used routinely, and in the periods 1992-2008 and 2008-2016. METHODS: 1903 Definite (DFH) and 1650 Possible (PFH) patients (51% women) aged 20-79 years, recruited from 21 lipid clinics in the United Kingdom and followed prospectively between 1980 and 2016 for 67,060 person-years...
May 1, 2018: Atherosclerosis
A Estrada-Angulo, F Coronel-Burgos, B I Castro-Pérez, A Barreras, R A Zinn, L Corona-Gochi, A Plascencia
Sorghum panicle residue (SPR), a by-product of Sorghum vulgare, obtained in the manufacture of brooms and wisks, has potential as a partial substitute for grain in growing-finishing diets for feedlot lambs. Accordingly, 48 Pelibuey×Katahdin lambs (initial weight=16.2±4.3 kg) were used in an 84-d growth-performance trial to evaluate its comparative feeding value. Lambs were blocked by weight and assigned within weight groupings to 12 pens (4 lambs per pen). The SPR was finely ground before it was incorporated into the diet...
May 9, 2018: Animal: An International Journal of Animal Bioscience
Billie Castle, Monica Wendel, Jelani Kerr, Derrick Brooms, Aaron Rollins
OBJECTIVES: Recently, public health has acknowledged racism as a social determinant of health. Much evidence exists on the impact of individual-level racism and discrimination, with little to no examination of racism from the standpoint of systems and structures. The purpose of this systematic literature review is to analyze the extent to which public health currently addresses systemic racism in the published literature. METHODS: Utilizing the PRISMA guidelines, this review examines three widely used databases to examine published literature covering the topic as well as implications for future research and practice...
May 4, 2018: Journal of Racial and Ethnic Health Disparities
C S Paththinige, J R D K Rajapakse, G R Constantine, K P Sem, R R Singaraja, R W Jayasekara, V H W Dissanayake
BACKGROUND: Hypercholesterolemia is a major determinant of cardiovascular disease-associated morbidity and mortality. Mutations in the LDL-receptor (LDLR) gene are implicated in the majority of the cases with familial hypercholesterolemia (FH). However, the spectrum of mutations in the LDLR gene in Sri Lankan patients has not been investigated. The objective of this study was to report the frequency and spectrum of variants in LDLR in a cohort of Sri Lankan patients with FH. METHODS: A series of consecutive patients with FH, diagnosed according to Modified Simon Broome criteria or Dutch Lipid Clinic Network criteria at the University Medical Unit, Colombo, were recruited...
May 2, 2018: Lipids in Health and Disease
Emma Quinn, Kai Hsiao, George Truman, Nectarios Rose, Richard Broome
Geographic information systems (GIS) have emerged in the past few decades as a technology capable of assisting in the control of infectious disease outbreaks. A Legionnaires' disease cluster investigation in May 2016 in Sydney, New South Wales (NSW), Australia, demonstrated the importance of using GIS to identify at-risk water sources in real-time for field investigation to help control any immediate environmental health risk, as well as the need for more staff trained in the use of this technology. Sydney Local Health District Public Health Unit (PHU) subsequently ran an exercise (based on this investigation) with 11 staff members from 4 PHUs across Sydney to further test staff capability to use GIS across NSW...
May 2, 2018: Disaster Medicine and Public Health Preparedness
Huiyu Wang, Xia Ye, Jidong Li, Bin Tan, Peng Chen, Jun Cheng, Wei Wang, Xianbo Zheng, Jiancan Feng
BACKGROUND: Jujube witches' broom (JWB), caused by a phytoplasma, devastates jujube tree (Ziziphus jujuba) growth and production in Asia. Although host responses to phytoplasmas are studied at the phenotypic, physiological, biochemical and molecular levels, it remains unclear how a host plant responds at the molecular level during the primary stage of infection. METHODS: To understand the response of the jujube tree to JWB infection, leaves were sampled at different times during the phytoplasma infection...
April 27, 2018: Gene
Leon J Broom, Michael H Kogut
The intestine performs the critical roles of nutrient acquisition, tolerance of innocuous and beneficial microorganisms, while retaining the ability to respond appropriately to undesirable microbes or microbial products and preventing their translocation to more sterile body compartments. Various components contribute to antimicrobial defenses in the intestine. The mucus layer(s), antimicrobial peptides and IgA provide the first line of defense, and seek to trap and facilitate the removal of invading microbes...
April 29, 2018: Animal Health Research Reviews
Marion E Broome, Dave Bowersox, Michael Relf
Public and private higher education funding models are shifting from traditional funding of schools and departments to a model in which schools increasingly rely on revenue other than tuition to fulfill and supplement activities related to their core missions. In this paper we discuss what nursing deans need to know about non tuition funding in this contemporary paradigm. We focus on how the Duke University School of Nursing created a Business Development Initiative (BDI) that provides additional revenue to help meets the financial needs of its' programs while nurturing the entrepreneurial spirit of faculty and staff...
March 2018: Journal of Professional Nursing: Official Journal of the American Association of Colleges of Nursing
Amy Lee Bredlau, Anjan Motamarry, Chao Chen, M A McCrackin, Kris Helke, Kent E Armeson, Katrina Bynum, Ann-Marie Broome, Dieter Haemmerich
Most drugs cannot penetrate the blood-brain barrier (BBB), greatly limiting the use of anti-cancer agents for brain cancer therapy. Temperature sensitive liposomes (TSL) are nanoparticles that rapidly release the contained drug in response to hyperthermia (>40 °C). Since hyperthermia also transiently opens the BBB, we hypothesized that localized hyperthermia can achieve drug delivery across the BBB when combined with TSL. TSL-encapsulated doxorubicin (TSL-Dox) was infused intravenously over 30 min at a dose of 0...
November 2018: Drug Delivery
John L Oliffe, Alex Broom, Mary T Kelly, Joan L Bottorff, Genevieve M Creighton, Olivier Ferlatte
Although male suicide has received research attention, the gendered experiences of men bereaved by male suicide are poorly understood. Addressing this knowledge gap, we share findings drawn from a photovoice study of Canadian-based men who had lost a male friend, partner, or family member to suicide. Two categories depicting the men's overall account of the suicide were inductively derived: (a) unforeseen suicide and (b) rationalized suicide. The "unforeseen suicides" referred to deaths that occurred without warning wherein participants spoke to tensions between having no idea that the deceased was at risk while reflecting on what they might have done to prevent the suicide...
April 1, 2018: Qualitative Health Research
Guoqiang Fan, Yabing Cao, Zhe Wang
Paulownia witches' broom caused by phytoplasma infection affects the production of Paulownia trees worldwide. Emerging evidence showed that long noncoding RNAs (lncRNA) play a protagonist role in regulating the expression of genes in plants. So far, the identification of lncRNAs has been limited to a few model plant species, and their roles in mediating responses to Paulownia tomentosa that free of phytoplasma infection are yet to be characterized. Here, whole-genome identification of lncRNAs, based on strand-specific RNA sequencing, from four Paulownia tomentosa samples, was performed and identified 3689 lncRNAs...
2018: International Journal of Genomics
Michel S McElroy, Alberto J R Navarro, Guiliana Mustiga, Conrad Stack, Salvador Gezan, Geover Peña, Widem Sarabia, Diego Saquicela, Ignacio Sotomayor, Gavin M Douglas, Zoë Migicovsky, Freddy Amores, Omar Tarqui, Sean Myles, Juan C Motamayor
Cacao ( Theobroma cacao ) is a globally important crop, and its yield is severely restricted by disease. Two of the most damaging diseases, witches' broom disease (WBD) and frosty pod rot disease (FPRD), are caused by a pair of related fungi: Moniliophthora perniciosa and Moniliophthora roreri , respectively. Resistant cultivars are the most effective long-term strategy to address Moniliophthora diseases, but efficiently generating resistant and productive new cultivars will require robust methods for screening germplasm before field testing...
2018: Frontiers in Plant Science
Trevor Simper, Caroline Dalton, David Broom, Waleed Ibrahim, Lingjin Li, Charles Bankole, Sisi Chen
There are ethnic differences recorded in glycaemic response and rates of type 2 diabetes mellitus (DM) between Chinese and Caucasian populations. Whether these differences are evident in matched healthy, lean, active, young adults is unclear. This study compares the postprandial glycaemic response of a group of Chinese participants ( n = 49) with a group of similar Caucasians, ( n = 48) aged 23.8 (±4.35 years), body mass index (BMI) 22.7 (±2.6) kg/m², healthy (free from non-communicable disease), and lean (body fat % 23...
April 14, 2018: Nutrients
C E Alvarez, F Trajtenberg, N Larrieux, M Saigo, A Golic, C S Andreo, S A Hogenhout, M A Mussi, M F Drincovich, A Buschiazzo
Phytoplasmas are wall-less phytopathogenic bacteria that produce devastating effects in a wide variety of plants. Reductive evolution has shaped their genome, with the loss of many genes, limiting their metabolic capacities. Owing to the high concentration of C4 compounds in plants, and the presence of malic enzyme (ME) in all phytoplasma genomes so far sequenced, the oxidative decarboxylation of L-malate might represent an adaptation to generate energy. Aster yellows witches'-broom (Candidatus Phytoplasma) ME (AYWB-ME) is one of the smallest of all characterized MEs, yet retains full enzymatic activity...
April 1, 2018: Acta Crystallographica. Section D, Structural Biology
Chaoling Xue, Zhiguo Liu, Li Dai, Jiaodi Bu, Mengjun Liu, Zhihui Zhao, Zihui Jiang, Weilin Gao, Jin Zhao
Phytoplasmas parasitize plant phloem tissue and cause many economically important plant diseases. Jujube witches' broom disease is a destructive phytoplasma disease of Chinese jujube (Ziziphus jujuba Mill.). To elucidate the influence of phytoplasma on host photosynthetic, carbohydrate and energy metabolisms, four types of jujube tissues showing disease symptoms with different severity were investigated at the structural, physiological and molecular levels. qRT-PCR and HPLC results showed that the down-regulation of genes related to photosynthesis and the lower contents of chlorophyll in diseased leaves...
April 12, 2018: Phytopathology
Joshua A Horsley, Richard A Broome, Fay H Johnston, Martin Cope, Geoffrey G Morgan
No abstract text is available yet for this article.
April 16, 2018: Medical Journal of Australia
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