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https://www.readbyqxmd.com/read/28737082/myth-manners-and-medical-ritual-defensive-medicine-and-the-fetish-of-antibiotics
#1
Alex Broom, Emma Kirby, Alexandra F Gibson, Jeffrey J Post, Jennifer Broom
Given the global crisis of antimicrobial resistance, the continued misuse of antibiotics is perplexing, particularly despite persistent attempts to curb usage. This issue extends beyond traditional "wastage" areas, of livestock and community medicine, to hospitals, raising questions regarding the current principles of hospital practice. Drawing on five focus group discussions, we explore why doctors act in the ways they do regarding antibiotics, revealing how practices are done, justified, and perpetuated. We posit that antibiotic misuse is better understood in terms of social relations of fear, survival and a desire for autonomy; everyday rituals, performances, and forms of professional etiquette; and the mixed obligations evident in the health sector...
July 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28734274/genetic-analysis-of-iranian-patients-with-familial-hypercholesterolemia
#2
Mahdis Ekrami, Maryam Torabi, Soudeh Ghafouri-Fard, Javad Mowla, Bahram Mohammad Soltani, Feyzollah Hashemi-Gorji, Zahra Mohebbi, Mohammad Miryounesi
Background: Familial hypercholesterolemia (FH) is a frequent autosomal dominant disorder of lipoprotein metabolism. This disorder is generally caused by mutations in low-density lipoprotein receptor (LDLR), apolipoprotein B 100 (APOB), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. In the present study, we aimed at identifying the common LDLR and APOB gene mutations in an Iranian population. Methods: Eighty unrelated Iranian patients with FH entered the study, based on Simon Broome diagnostic criteria...
July 23, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/28732477/a-web-based-clinical-decision-tool-to-support-treatment-decision-making-in-psychiatry-a-pilot-focus-group-study-with-clinicians-patients-and-carers
#3
Catherine Henshall, Lisa Marzano, Katharine Smith, Mary-Jane Attenburrow, Stephen Puntis, Jakov Zlodre, Kathleen Kelly, Matthew R Broome, Susan Shaw, Alvaro Barrera, Andrew Molodynski, Alastair Reid, John R Geddes, Andrea Cipriani
BACKGROUND: Treatment decision tools have been developed in many fields of medicine, including psychiatry, however benefits for patients have not been sustained once the support is withdrawn. We have developed a web-based computerised clinical decision support tool (CDST), which can provide patients and clinicians with continuous, up-to-date, personalised information about the efficacy and tolerability of competing interventions. To test the feasibility and acceptability of the CDST we conducted a focus group study, aimed to explore the views of clinicians, patients and carers...
July 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28726346/imaging-characteristics-and-treatment-of-a-penetrating-brain-injury-caused-by-an-oropharyngeal-foreign-body-in-a-dog
#4
Jennifer McKenzie, Megan Cooper Murphy, Cameron Broome, Hamaseh Tayari, Rodrigo Gutierrez-Quintana
A 4-year-old Border collie was presented with one episode of collapse, altered mentation, and a suspected pharyngeal stick injury. Magnetic resonance imaging (MRI) and computed tomography showed a linear foreign body penetrating the right oropharynx, through the foramen ovale and the brain parenchyma. The foreign body was surgically removed and medical treatment initiated. Complete resolution of clinical signs was noted at recheck 8 weeks later. Repeat MRI showed chronic secondary changes in the brain parenchyma...
July 20, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28719550/does-an-annular-puncture-influence-the-herniation-path-an-in-vitro-mechanical-and-structural-investigation
#5
Vonne M van Heeswijk, Ashvin Thambyah, Peter A Robertson, Neil D Broom
STUDY DESIGN: A study of mechanically-induced herniation in punctured ovine discs followed by structural analysis. OBJECTIVE: To investigate whether an annular puncture influences the path that herniation takes by providing direct passage for nucleus through the annulus and therefore whether it increases the risk of acute herniation from overload at the site of damage independent of any longer-term degeneration. SUMMARY OF BACKGROUND DATA: 10 years after treatment with discography both degenerative changes and frequency of herniation have been shown to increase compared to untreated discs...
July 17, 2017: Spine
https://www.readbyqxmd.com/read/28710274/computational-tools-help-improve-protein-stability-but-with-a-solubility-tradeoff
#6
Aron Broom, Zachary Jacobi, Kyle Trainor, Elizabeth M Meiering
Accurately predicting changes in protein stability upon amino acid substitution is a much sought after goal. Destabilizing mutations are often implicated in disease, while stabilizing mutations are of great value for industrial and therapeutic biotechnology. Increasing protein stability is an especially challenging task, with random substitution yielding stabilizing mutations in only ~2% of cases. To overcome this bottleneck, computational tools that aim to predict the effect of mutations have been developed; however, achieving accuracy and consistency remains challenging...
July 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28708141/static-ft-imaging-spectrometer-based-on-a-modified-waveguide-mzi-array
#7
Minyue Yang, Mingyu Li, Jian-Jun He
We proposed a large aperture push-broom static Fourier transform (FT) imaging spectrometer for hyper-spectral imaging. The spectroscopic system was based on the silicon-on-insulator (SOI) platform, consisting of spot size converters, a Mach-Zehnder interferometer (MZI) array, and a detector array. The arm length differences of the 201 MZI arrays are linearly varied. It is one on-chip FT spectrometer operating in a large spectral range from 1100 to 1700 nm with a resolution of 24  cm<sup>-1</sup> and small foot print (chip size: 11  mm×15  mm)...
July 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28690927/quantitative-proteome-level-analysis-of-paulownia-witches-broom-disease-with-methyl-methane-sulfonate-assistance-reveals-diverse-metabolic-changes-during-the-infection-and-recovery-processes
#8
Zhe Wang, Wenshan Liu, Guoqiang Fan, Xiaoqiao Zhai, Zhenli Zhao, Yanpeng Dong, Minjie Deng, Yabing Cao
Paulownia witches' broom (PaWB) disease caused by phytoplasma is a fatal disease that leads to considerable economic losses. Although there are a few reports describing studies of PaWB pathogenesis, the molecular mechanisms underlying phytoplasma pathogenicity in Paulownia trees remain uncharacterized. In this study, after building a transcriptome database containing 67,177 sequences, we used isobaric tags for relative and absolute quantification (iTRAQ) to quantify and analyze the proteome-level changes among healthy P...
2017: PeerJ
https://www.readbyqxmd.com/read/28685289/erratum-to-complete-genome-sequence-of-longan-witches-broom-associated-virus-a-novel-member-of-the-family-potyviridae
#9
Jang-Kyun Seo, Mi-Kyeong Kim, Hae-Ryun Kwak, Jeong-Soo Kim, Hong-Soo Choi
No abstract text is available yet for this article.
July 7, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28672800/use-of-vegetable-fibers-for-prb-to-remove-heavy-metals-from-contaminated-aquifers-comparisons-among-cabuya-fibers-broom-fibers-and-zvi
#10
Celia Margarita Mayacela Rojas, María Fernanda Rivera Velásquez, Adalgisa Tavolaro, Antonio Molinari, Carmine Fallico
The Zero Valent Iron (ZVI) is the material most commonly used for permeable reactive barriers (PRB). For technical and economic reasons, hoter reactive substances usable in alternative to ZVI are investigated. The present study takes into account a vegetable fibers, the cabuya, investigating its capacity to retain heavy metals. The capacity of the cabuya fibers to adsorb heavy metals was verified in laboratory, by batch and column tests. The batch tests were carried out with cabuya and ZVI, using copper (Cu), zinc (Zn), cadmium (Cd) and lead (Pb)...
June 24, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28670254/trichoscopy-of-scalp-dysesthesia
#11
Adriana Rakowska, Małgorzata Olszewska, Lidia Rudnicka
INTRODUCTION: Scalp dysesthesia is characterized by localized pruritus, burning sensations or even pain. AIM: To describe characteristic trichoscopic features of scalp dysesthesia. MATERIAL AND METHODS: The study was a retrospective analysis (2010-2016) of 9 patients (8 females and 1 male; median age: 52 years; range: 38-66 years). A total of 61 trichoscopic images were analyzed by two independent evaluators. RESULTS: In all cases, oval or round areas covered with short hairs: broom hairs (77%; 7/9), block hairs (88%; 8/9), short hairs with trichorrhexis nodosa (78%; 7/9) were found...
June 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28666764/evolutionary-dynamics-and-the-evolution-of-multiplayer-cooperation-in-a-subdivided-population
#12
Karan Pattni, Mark Broom, Jan Rychtář
The classical models of evolution have been developed to incorporate structured populations using evolutionary graph theory and, more recently, a new framework has been developed to allow for more flexible population structures which potentially change through time and can accommodate multiplayer games with variable group sizes. In this paper we extend this work in three key ways. Firstly by developing a complete set of evolutionary dynamics so that the range of dynamic processes used in classical evolutionary graph theory can be applied...
September 21, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28663044/carotid-artery-plaques-are-risk-factors-the-same-in-men-and-women-with-familial-hypercholesterolemia
#13
Małgorzata Waluś-Miarka, Danuta Czarnecka, Małgorzata Kloch-Badełek, Wiktoria Wojciechowska, Maria Kapusta, Maciej T Malecki
BACKGROUND AND AIMS: High low-density lipoprotein (LDL)-cholesterol levels are a major cause of premature coronary heart disease (CHD) and death in patients with familial hypercholesterolemia (FH). It is uncertain whether these risk factors affect men and women equally. We aimed to compare the risk factors of carotid plaques, which are reliable surrogates of coronary atherosclerosis, in men and women with FH. METHODS: 154 patients with FH (40.9% men) were included, diagnosed according to Simon Broome criteria...
June 21, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28661028/increased-use-of-heated-humidified-high-flow-nasal-cannula-is-associated-with-longer-oxygen-requirements
#14
Rachael C Heath Jeffery, Margaret Broom, Bruce Shadbolt, David A Todd
AIM: There has been an increased use of heated humidified high flow nasal canula (HFNC) in premature babies (PBs) admitted to our neonatal unit. The aim of this study is to identify clinical characteristics in PBs < 29 weeks gestational age (GA) that distinguish between those who did not or did receive HFNC. METHODS: This study compared prospectively collected data from 2010 to 2012. Comparisons were undertaken between PBs<29 weeks GA who received continuous positive airway pressure (CPAP: 44/72 (61...
June 29, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/28652183/genome-wide-identification-and-characterization-of-the-spl-gene-family-in-ziziphus-jujuba
#15
Fenjuan Shao, Qiang Lu, Iain W Wilson, Deyou Qiu
SQUAMOSA Promoter-Binding Protein-Likes (SPLs) are plant specific transcription factors playing important roles in plant growth and development. The SPL gene family has been studied in various plant species; however, there is no report about SPLs in Zizyphus jujuba. In this study, we identified 18 putative ZjSPL genes in Z. jujuba using a genome-wide analysis. Sequence features, gene structures, conserved domains and motifs were analyzed. The phylogenetic relationships of SPLs in Z. jujuba and A. thaliana were revealed...
June 23, 2017: Gene
https://www.readbyqxmd.com/read/28649859/medical-authority-managerial-power-and-political-will-a-bourdieusian-analysis-of-antibiotics-in-the-hospital
#16
Emma Kirby, Alex Broom, Alexandra Gibson, Jennifer Broom, Trent Yarwood, Jeffrey Post
Antibiotic resistance poses a significant global threat, yet clinically inappropriate antibiotic use within hospitals continues despite the implementation of abatement strategies. Antibiotic use and the viability of existing antibiotic options now sit precariously at the nexus of political will, institutional governance and clinical priorities 'at the bedside'. Yet no study has hitherto explored the perspectives of managers, instead of focusing on clinicians. In this article, drawing on qualitative interviews with hospital managers, we explore accounts of responding to antimicrobial resistance, managing antibiotic governance and negotiating clinical and managerial priorities...
June 1, 2017: Health (London)
https://www.readbyqxmd.com/read/28642193/unusual-x-ray-finding-after-mandibular-reconstruction
#17
H Zrounba, E Lanthemann, M Broome
No abstract text is available yet for this article.
June 19, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28638944/the-effect-of-fight-cost-structure-on-fighting-behaviour-involving-simultaneous-decisions-and-variable-investment-levels
#18
Mark Broom, Michal Johanis, Jan Rychtář
In the "producer-scrounger" model, a producer discovers a resource and is in turn discovered by a second individual, the scrounger, who attempts to steal it. This resource can be food or a territory, and in some situations, potentially divisible. In a previous paper we considered a producer and scrounger competing for an indivisible resource, where each individual could choose the level of energy that they would invest in the contest. The higher the investment, the higher the probability of success, but also the higher the costs incurred in the contest...
June 21, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28635585/the-meaning-and-experience-of-bereavement-support-a-qualitative-interview-study-of-bereaved-family-caregivers
#19
Emma Kirby, Katherine Kenny, Alex Broom, John MacArtney, Phillip Good
OBJECTIVE: Experiences of bereavement can be stressful and are frequently complicated by emotional, familial, and financial issues. Some-though not all-caregivers may benefit from bereavement support. While considered standard within palliative care services in Australia, bereavement support is not widely utilized by family caregivers. There is little research focused on the forms of bereavement support desired or required by family caregivers, how such care is viewed, and/or how bereavement support is experienced...
June 21, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/28632156/image-mosaicking-approach-for-a-double-camera-system-in-the-gaofen2-optical-remote-sensing-satellite-based-on-the-big-virtual-camera
#20
Yufeng Cheng, Shuying Jin, Mi Wang, Ying Zhu, Zhipeng Dong
The linear array push broom imaging mode is widely used for high resolution optical satellites (HROS). Using double-cameras attached by a high-rigidity support along with push broom imaging is one method to enlarge the field of view while ensuring high resolution. High accuracy image mosaicking is the key factor of the geometrical quality of complete stitched satellite imagery. This paper proposes a high accuracy image mosaicking approach based on the big virtual camera (BVC) in the double-camera system on the GaoFen2 optical remote sensing satellite (GF2)...
June 20, 2017: Sensors
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