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JOURNAL ARTICLE
Alberto Lázaro-García, Daniel Láinez-González, Marta González-Rodríguez, Santiago Cano Alsua, Edwin Uriel Suárez M, Laura Solán-Blanco, Javier Cornago-Navascués, José Luis López-Lorenzo, Pilar Llamas-Sillero, Juan Manuel Alonso-Domínguez
CONTEXT: Music listening (ML) has been shown to have a beneficial effect on patients with cancer. However, novel intervention approaches are needed. OBJECTIVES: We aimed to determine whether ML based on the iso-principle, conducted using a mobile application (GloMus), improves symptom burden, quality of life (QoL), anxiety, and depression in patients undergoing stem cell transplantation (SCT) and intensive induction chemotherapy for acute myeloid leukemia (AML)...
March 4, 2024: Journal of Pain and Symptom Management
#22
JOURNAL ARTICLE
Caroline Dartigeas, Anne Quinquenel, Loïc Ysebaert, Marie-Sarah Dilhuydy, Bruno Anglaret, Borhane Slama, Katell Le Du, Stéphanie Tardy, Emmanuelle Tchernonog, Hubert Orfeuvre, Laurent Voillat, Stéphanie Guidez, Jean-Valère Malfuson, Sandrine Dupuis, Marine Deslandes, Pierre Feugier, Véronique Leblond
We conducted an observational study (FIRE) to understand the effectiveness and safety outcomes of ibrutinib in patients with chronic lymphocytic leukemia (CLL) in France, after a maximum follow-up of five years. Patients were included according to the French marketing authorization in 2016 (i.e. patients with relapsed or refractory CLL or to previously untreated CLL patients with deletion 17p and/or tumor protein p53 mutations unsuitable for chemoimmunotherapy) and could have initiated ibrutinib more than 30 days prior their enrolment in the study (i...
March 6, 2024: Annals of Hematology
#23
JOURNAL ARTICLE
Meixiang Wang, Jia Fang, Xiaoyan Hu, Tingting Cai, Fulei Wu, Yan Lin
PURPOSE: Children with leukemia may experience a range of chemotherapy-related symptoms. Identifying subgroups and their distinct characteristics of symptoms may improve symptom management. We aimed to identify subgroups and their distinct characteristics of chemotherapy-related symptoms in children with leukemia. METHODS: A cross-sectional survey was conducted among 500 children with leukemia, who completed questionnaires that assessed their demographic and clinical characteristics, as well as the Memorial Symptom Assessment Scale...
March 4, 2024: Supportive Care in Cancer
#24
REVIEW
Zhenzhen Su, Liyan Zhang, Xuemin Lian, Miaomiao Guan
BACKGROUND: Virtual reality-based exercise rehabilitation (VRER) is a promising intervention for patients with cancer-related dysfunctions (CRDs). However, studies focusing on VRER for CRDs are lacking, and the results are inconsistent. OBJECTIVE: We aimed to review the application of VRER in patients with CRDs. METHODS: This scoping review was conducted following the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) checklist framework...
February 26, 2024: Journal of Medical Internet Research
#25
JOURNAL ARTICLE
Danli Zhou, Qian Zhou, Wenjian Liu, Jianping Cai
BACKGROUND: Nutritional imbalances can significantly impact clinical efficacy and chemotherapy tolerance in cases of acute lymphoblastic leukemia. Despite the potential significance, there is limited research in this domain, and clinicians have paid limited attention to it. OBJECTIVE: This study aims to investigate the impact of continuous nutritional intervention on pediatric patients with acute lymphoblastic leukemia. METHODS: A comparative analysis was conducted by dividing the children into observation and control groups, examining the effects of intermittent diet intervention and continuous nutrition intervention post-nutritional risk assessment...
February 9, 2024: Alternative Therapies in Health and Medicine
#26
JOURNAL ARTICLE
Xiao-Fang Chen, Xian-Ling Chen, Yuan-Zhong Chen
OBJECTIVE: To investigate the effect of TCP1 expression on the proliferation and the accumulation of intracellular drug of HL60/A and HL60 cells and its possible molecular mechanism. METHODS: Lentiviral transfection technology was used to construct HL60/A and HL60 cells with knocked down or overexpressed TCP1 and their control cells. The efficiency of knockdown and overexpression was evaluated by Western blot. The cell proliferation was detected by CCK-8 assay. The intracellular drug accumulation was detected by laser confocal detection and flow cytometry...
February 2024: Zhongguo Shi Yan Xue Ye Xue za Zhi
#27
JOURNAL ARTICLE
Hengxu Liu, Jingqi Yin, Kun Wang, Shiqi Liu, Yi Yang, Ziyi Song, Caiyun Dong, Tingran Zhang, Jiong Luo
OBJECTIVE: To systematically evaluate the impact of physical exercise intervention on children with acute lymphoblastic leukemia (ALL) during the treatment and rehabilitation consolidation periods. METHOD: Randomized controlled trials (RCTs) were retrieved from PubMed, Scopus, Web of Science, CNKI, and Cochrane databases, with a search time range from database establishment to September 1, 2023. The quality of the included RCTs was evaluated using the Cochrane risk assessment tool, and a systematic evaluation was conducted using RevMan 5...
February 21, 2024: Supportive Care in Cancer
#28
REVIEW
Leila Ahmadinia, Shahid B Rangrej, Maria Miranda, Christine Shailer, Waleed Ahmed, Victoria Carvalho, Rajni Rathore
Hematopoietic stem-cell transplantation (HSCT) has emerged as a groundbreaking therapeutic option for acute myeloid leukemia (AML) and specific subtypes of acute lymphoblastic leukemia (ALL). The prognostic significance of the NOD2/CARD15 gene has been explored alongside various factors, encompassing diverse patient cohorts and gene variants. Siblings and unrelated donors used for stem cell transplantation exhibit significant associations between their genetic variations and graft-versus-host disease incidence...
January 2024: Curēus
#29
JOURNAL ARTICLE
Maddalena Migliavacca, Federica Barzaghi, Claudia Fossati, Paola M V Rancoita, Michela Gabaldo, Francesca Dionisio, Stefania Giannelli, Federica Andrea Salerio, Francesca Ferrua, Francesca Tucci, Valeria Calbi, Vera Gallo, Salvatore Recupero, Giulia Consiglieri, Roberta Pajno, Maria Sambuco, Alessio Priolo, Chiara Ferri, Vittoria Garella, Ilaria Monti, Paolo Silvani, Silvia Darin, Miriam Casiraghi, Ambra Corti, Stefano Zancan, Margherita Levi, Daniela Cesana, Filippo Carlucci, Anna Pituch-Noworolska, Dalia AbdElaziz, Ulrich Baumann, Andrea Finocchi, Caterina Cancrini, Saverio Ladogana, Andrea Meinhardt, Isabelle Meyts, Davide Montin, Lucia Dora Notarangelo, Fulvio Porta, Marlène Pasquet, Carsten Speckmann, Polina Stepensky, Alberto Tommasini, Marco Rabusin, Zeynep Karakas, Miguel Galicchio, Lucia Leonardi, Marzia Duse, Sukru Nail Guner, Clelia Di Serio, Fabio Ciceri, Maria Ester Bernardo, Alessandro Aiuti, Maria Pia Cicalese
Adenosine deaminase (ADA) deficiency leads to severe combined immunodeficiency (SCID). Previous clinical trials showed that autologous CD34+ cell gene therapy (GT) following busulfan reduced-intensity conditioning is a promising therapeutic approach for ADA-SCID, but long-term data are warranted. Here we report an analysis on long-term safety and efficacy data of 43 patients with ADA-SCID who received retroviral ex vivo bone marrow-derived hematopoietic stem cell GT. Twenty-two individuals (median follow-up 15...
February 14, 2024: Nature Medicine
#30
Tomoki Aoyama, Mari Matsuoka
A 26-year-old woman previously treated for acute lymphoblastic leukemia (ALL) 14 years ago faced challenges in managing chronic pain resulting from right femoral head necrosis, a complication of her earlier ALL treatment. Ultimately, the persistent chronic pain was successfully treated via a comprehensive rehabilitation approach. The patient presented with hip contractures, muscle weakness, and reduced endurance without evident arthropathic changes or inflammatory findings in the femoral head. Active physiotherapy was implemented with the primary objective of increasing her social activity...
January 2024: Curēus
#31
REVIEW
Mukesh Kumar Manickasamy, Anjana Sajeev, Bandari BharathwajChetty, Mohammed S Alqahtani, Mohamed Abbas, Mangala Hegde, Babu Santha Aswani, Mehdi Shakibaei, Gautam Sethi, Ajaikumar B Kunnumakkara
Hematological malignancies (HM) represent a subset of neoplasms affecting the blood, bone marrow, and lymphatic systems, categorized primarily into leukemia, lymphoma, and multiple myeloma. Their prognosis varies considerably, with a frequent risk of relapse despite ongoing treatments. While contemporary therapeutic strategies have extended overall patient survival, they do not offer cures for advanced stages and often lead to challenges such as acquisition of drug resistance, recurrence, and severe side effects...
February 9, 2024: Cellular and Molecular Life Sciences: CMLS
#32
JOURNAL ARTICLE
Megan Rodriguez, Baharan Fekry, Brianna Murphy, Mary Figueroa, Tiewei Cheng, Margaret Raber, Lisa Wartenberg, Donna Bell, Lisa Triche, Karla Crawford, Huaxian Ma, Kendra Allton, Ruwaida Ahmed, Jaime Tran, Christine Ranieri, Marina Konopleva, Michelle Barton, Cesar Nunez, Kristin Eckel-Mahan, Joya Chandra
BACKGROUND: Acute myeloid leukemia (AML) with an internal tandem duplication in the fms-like tyrosine kinase receptor 3 gene (FLT3-ITD) is associated with poor survival, and few studies have examined the impact of modifiable behaviors, such as nutrient quality and timing, in this subset of acute leukemia. METHODS: The influence of diet composition (low-sucrose and/or low-fat diets) and timing of diet were tested in tandem with anthracycline treatment in orthotopic xenograft mouse models...
January 2024: Cancer Medicine
#33
JOURNAL ARTICLE
Xia Wu, Jiao Chao, Qiufang Xu
BACKGROUND: Allogeneic hematopoietic stem cell transplantation stands as a vital treatment for leukemia, yet its implementation poses considerable challenges and complications. A comprehensive understanding of these challenges is crucial for appreciating the significance of enhanced nursing care. OBJECTIVE: To explore and summarise the nursing experience of allogeneic haematopoietic stem cell transplantation for acute lymphoblastic leukaemia. The significance of this objective lies in the potential transformative impact that enhanced nursing care can have on overall patient outcomes within the context of allogeneic hematopoietic stem cell transplantation...
January 31, 2024: Alternative Therapies in Health and Medicine
#34
JOURNAL ARTICLE
Shuzhang Sun, Yixuan Cheng, Wanxin Hou, Yinjie Yan, Tian Meng, Hegen Li, Ning Xiao
Chemotherapy is the most common treatment for acute lymphoblastic leukemia (ALL). However, many ALL patients eventually develop relapse and treating relapsed ALL has always been challenging. Therefore, exploring the resistance mechanism of chemotherapeutic drugs and proposing feasible intervention strategies are of great significance for ALL treatment. Here, we show that SENP8, whose coding protein is an important deNEDDylase targeting the substrate for deNEDDylation, is highly expressed in relapsed ALL specimens...
March 2024: Biochemistry and Biophysics Reports
#35
JOURNAL ARTICLE
Hazal Ozdemir Koyu, Gökce Algül, Naime Altay, Ebru Kilicarslan
PURPOSE: Hope in pediatric oncology guides parents as an inner guidance compass through their child's challenging journey toward cancer treatment. This study was designed to examine the effects of psychological resilience, spiritual well-being, and some child- and parent-related factors on parents' experience of hope while their child is undergoing cancer treatment. DESIGN AND METHODS: This cross-sectional, correlational study was conducted between March and July 2022 in the pediatric oncology-hematology ward of a university hospital in Turkey...
February 1, 2024: Journal of Pediatric Nursing
#36
JOURNAL ARTICLE
Chai-Eng Tan, Novia Admodisastro, Sie Chong Doris Lau, Kit Aun Tan, Kok Hoi Teh, Chee Chan Lee, Sherina Mohd Sidik
OBJECTIVE: Malaysian parents of children diagnosed with leukemia or lymphoma stand to benefit from a comprehensive Malay-language online resource, complementing existing caregiver education practices. This study aimed to develop and assess the efficacy of e-Hematological Oncology Parents Education (e-HOPE), an online caregiver education resource in Malay, designed to enhance the knowledge of parents with children diagnosed with leukemia or lymphoma in Malaysia. METHODS: A user profile and topic list were established based on previous needs analysis studies...
February 2024: Asia-Pacific Journal of Oncology Nursing
#37
JOURNAL ARTICLE
Neuronatin Promotes the Progression of Non-Small Cell Lung Cancer by Activating the NF-κB Signaling.
Huanwen Xiong, Guohua Chen, Ke Fang, Weiguo Gu, Feng Qiu
BACKGROUND AND OBJECTIVE: Understanding the regulatory mechanisms involving neuronatin (NNAT) in non-small cell lung cancer (NSCLC) is an ongoing challenge. This study aimed to elucidate the impact of NNAT knockdown on NSCLC by employing both in vitro and in vivo approaches. METHODS: To investigate the role of NNAT, its expression was silenced in NSCLC cell lines A549 and H226. Subsequently, various parameters, including cell proliferation, invasion, migration, and apoptosis, were assessed...
January 30, 2024: Current Cancer Drug Targets
#38
JOURNAL ARTICLE
Yin-Xiao Du, Jing Yang, Han Yan, Yan-Ling Liu, Xiao-Ping Chen
Cytarabine (Ara-C) is widely used in the induction chemotherapy for acute myeloid leukemia (AML). Association between LncRNA GAS5 genetic polymorphism and the recovery of hematopoietic function after Ara-C-based chemotherapy is observed. This study aimed to identify whether intervention of GAS5 expression and GAS5 genotype affect Ara-C-induced inhibition of hematopoietic stem cells (HSCs) differentiation. In this study, cord blood-derived CD34+ cells were cultured in vitro, and a cell model of myelosuppression was established by treatment of CD34+ cells with Ara-C...
January 28, 2024: Toxicology and Applied Pharmacology
#39
REVIEW
Mohamed El-Tanani, Hamdi Nsairat, Ismail I Matalka, Yin Fai Lee, Manfredi Rizzo, Alaa A Aljabali, Vijay Mishra, Yachana Mishra, Altijana Hromić-Jahjefendić, Murtaza M Tambuwala
Chronic Myeloid Leukemia (CML) is characterized by chromosomal aberrations involving the fusion of the BCR and ABL genes on chromosome 22, resulting from a reciprocal translocation between chromosomes 9 and 22. This fusion gives rise to the oncogenic BCR-ABL, an aberrant tyrosine kinase identified as Abl protein. The Abl protein intricately regulates the cell cycle by phosphorylating protein tyrosine residues through diverse signaling pathways. In CML, the BCR-ABL fusion protein disrupts the first exon of Abl, leading to sustained activation of tyrosine kinase and resistance to deactivation mechanisms...
January 22, 2024: Pathology, Research and Practice
#40
JOURNAL ARTICLE
Emanuel Quartin, Susana Rosa, Sara Gonzalez-Anton, Laura Mosteo Lopez, Vitor Francisco, Delfim Duarte, Cristina Lo Celso, Ricardo Pires das Neves, Lino Ferreira
More effective approaches are needed in the treatment of blood cancers, in particular acute myeloid leukemia (AML), that are able to eliminate resistant leukemia stem cells (LSCs) at the bone marrow (BM), after a chemotherapy session, and then enhance hematopoietic stem cell (HSC) engraftment for the re-establishment of the HSC compartment. Here, we investigate whether light-activatable nanoparticles (NPs) encapsulating all-trans-retinoic acid (RA+ NPs) could solve both problems. Our in vitro results show that mouse AML cells transfected with RA+ NPs differentiate towards antitumoral M1 macrophages through RIG...
April 2024: Bioactive Materials
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