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https://www.readbyqxmd.com/read/29785640/switching-from-high-fat-diet-to-foods-containing-resveratrol-as-a-calorie-restriction-mimetic-changes-the-architecture-of-arcuate-nucleus-to-produce-more-newborn-anorexigenic-neurons
#1
Maryam Safahani, Hadi Aligholi, Farshid Noorbakhsh, Mahmoud Djalali, Hamideh Pishva, Sayed Mostafa Modarres Mousavi, Leila Alizadeh, Ali Gorji, Fariba Koohdani
PURPOSE: These days, obesity threatens the health for which one of the main interventions is calorie restriction (CR). Due to the difficulty of compliance with this treatment, CR mimetics such as resveratrol (RSV) have been considered. The present study compared the effects of RSV and CR on hypothalamic remodeling in a diet-switching experiment. METHODS: C57BL/6 male mice received high-fat diet (HFD) for 4 weeks, subsequently their diet switched to chow diet, HFD + RSV, chow diet + RSV or CR diet for a further 6 weeks...
May 21, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29776868/hemorrhagic-cystitis-after-hematopoietic-stem-cell-transplantation-a-challenge-for-the-pediatric-urologist
#2
REVIEW
Romy Gander, Marino Asensio, Gabriela Guillén, Gloria Fatou Royo, Andrea Bolaños, Mercedes Pérez, Cristina Diaz-De-Heredia, Maribel Benitez, Manuel López
OBJECTIVE: Hemorrhagic cystitis (HC) is a serious event that can occur after hematopoietic stem cell transplantation (HSCT). Treatment goals are primarily to preserve life, and then the functionality of the bladder. There is no standard therapeutic approach for HC. Described treatment options provide low success rates and are related to potential life-threatening side effects. The aim of this study was to describe our experience in treatment of HC following HSCT. PATIENTS AND METHODS: This was a retrospective study of patients with HC treated at our institution between January 2010 and October 2016...
April 20, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29772082/child-symptoms-parent-behaviors-and-family-strain-in-long-term-survivors-of-childhood-acute-lymphoblastic-leukemia
#3
I-Chan Huang, Tara M Brinkman, Larry Mullins, Ching-Hon Pui, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: How family environment and parental factors affect health status and symptoms in childhood cancer survivors is understudied. We examined the influence of family cohesion, parent distress, and overprotection on child symptom burden and health-related quality of life (HRQOL) and family strain in survivors of childhood acute lymphoblastic leukemia (ALL). METHODS: Parents of 213 children treated with chemotherapy-only completed a survey when survivors were at least five-years post-diagnosis...
May 17, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29771338/cost-effectiveness-analysis-of-an-adherence-promotion-intervention-for-children-with-leukemia-a-markov-model-based-simulation
#4
Meghan E McGrady, Mark H Eckman, Maureen M O'Brien, Ahna L H Pai
Objective: Improving medication adherence among children with B-cell precursor acute lymphoblastic leukemia (B-ALL) has the potential to reduce relapse rates but requires an investment in resources. An economic evaluation is needed to understand the potential costs and benefits of delivering adherence-promotion interventions (APIs) as part of standard clinical care. Methods: A Markov decision analytic model was used to simulate the potential incremental cost-effectiveness per quality-adjusted life year (QALY) to be gained from an API for children with B-ALL in first continuous remission compared with treatment as usual (TAU, no intervention)...
May 15, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29741279/testing-physical-function-in-children-undergoing-intense-cancer-treatment-a-respect-feasibility-study
#5
Martin K F Nielsen, Jesper F Christensen, Thomas L Frandsen, Troels Thorsteinsson, Lars B Andersen, Karl B Christensen, Jacob Nersting, Marianne Faber, Kjeld Schmiegelow, Hanne B Larsen
BACKGROUND: The physical function of children with cancer is reduced during treatment, which can compromise the quality of life and increase the risk of chronic medical conditions. The study, "REhabilitation, including Social and Physical activity and Education in Children and Teenagers with cancer" (Clinicaltrials.gov: NCT01772862) examines the efficacy of multimodal rehabilitation strategies introduced at cancer diagnosis. This article addresses the feasibility of and obstacles to testing physical function in children with cancer...
May 9, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29701183/-in-vitro-study-of-joint-intervention-of-e-cad-and-bmi-1-mediated-by-transcription-activator-like-effector-nuclease-in-nasopharyngeal-carcinoma
#6
Tingting Luo, Aifen Yan, Lian Liu, Hong Jiang, Cuilan Feng, Guannan Liu, Fang Liu, Dongsheng Tang, Tianhong Zhou
To explore the effect of intervention of E-cadherin (E-cad) and B-lymphoma Moloney murine leukemia virus insertion region-1 (Bmi-1) mediated by transcription activator-like effector nuclease (TALEN) on the biological behaviors of nasopharyngeal carcinoma cells.
 Methods: Multi-locus gene targeting vectors pUC-DS1-CMV-E-cad-2A-Neo-DS2 and pUC-DS1-Bmi-1 shRNA-Zeo-DS2 were constructed, and the E-cad and Bmi-1 targeting vectors were transferred with TALEN plasmids to CNE-2 cells individually or simultaneously...
March 28, 2018: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29698556/more-frequent-use-of-health-care-services-among-distressed-compared-with-nondistressed-survivors-of-lymphoma-and-chronic-lymphocytic-leukemia-results-from-the-population-based-profiles-registry
#7
Lindy P J Arts, Simone Oerlemans, Lidwine Tick, Ad Koster, Henk T J Roerdink, Lonneke V van de Poll-Franse
BACKGROUND: Follow-up care for a growing population of survivors of lymphoma and chronic lymphocytic leukemia (CLL) together with the adverse effects these survivors may experience as a result of their cancer and treatment have led to more pressure being placed on health care services. The objectives of the current study were to: 1) compare the use of medical care services by survivors with that of a normative population; 2) evaluate the use of medical and psychosocial care services among distressed and nondistressed survivors; and 3) identify associated sociodemographic and clinical factors...
April 26, 2018: Cancer
https://www.readbyqxmd.com/read/29682216/physical-training-interventions-for-children-and-teenagers-affected-by-acute-lymphoblastic-leukemia-and-related-treatment-impairments
#8
REVIEW
Carolina Simioni, Giorgio Zauli, Alberto M Martelli, Marco Vitale, Simona Ultimo, Daniela Milani, Luca M Neri
A decreased physical fitness has been reported in patients and survivors of acute lymphoblastic leukemia (ALL). This is influenced by the negative effects of the disease and by the treatments of childhood cancer. In the past, children were advised to recover in bed, and to take as much relax as possible. Nowadays, it is considered that too much immobility may result in a further decrease of physical fitness and functioning. Exercise training for ALL children has frequently been reported to improve physical fitness and the well-being of the children, since it prevents the negative effects of a sedentary life-style, such as obesity and a poor skeletal health...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29658352/chronic-subdural-collection-overlying-an-intra-axial-hemorrhagic-lesion-in-chronic-myelomonocytic-leukemia-special-report-and-review-of-the-literature
#9
Anne-Laure Bernat, Stefano Maria Priola, Ahmad Elsawy, Faisal Farrash, Shervin Taslimi, Fred Gentili
Chronic myelomonocytic leukaemia (CMML) is a clonal hematopoietic stem cell disorder characterized by the presence of an absolute monocytosis in the peripheral blood (>1 x 109 /L) and the presence of myelodysplastic and myeloproliferative features in the bone marrow. Involvement of the central nervous system (CNS) is uncommon in CMML. Areas covered: Herein described is a case report of a CMML patient who presents with symptomatic chronic subdural collection overlying a haemorrhagic brain lesion, along with diffuse dural infiltration, after two cycles of azacytidine...
April 19, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29531929/determination-relation-of-the-zinc-serum-level-in-acute-leukemia-adult-patients-with-mucositis-and-neutropenic-prevalence-before-and-after-treatment-in-isfahan-seyed-al-shohada-hospital-2012-2013
#10
Valiollah Mehrzad, Mehdi Mahmood-Zadeh, Awat Feizi, Arash Raisi
Background: Neutropenic fever and mucositis with 70% outbreak average is one of the major reasons of death in the acute leukemia adult patients. The aim of this study was to determine the relationship of serum zinc level with neutropenic fever and mucositis prevalence in acute leukemia adult patients and comparison of the effects of therapeutic intervention with the serum zinc correct level in the group of patients with zinc deficiency. Materials and Methods: From May 2012 to May 2013 in a double-blind, randomized, placebo-controlled study, on the basis of zinc serum level, 40 acute leukemia adult patients were divided into two groups of normal and deficiency zinc, and neutropenic fever and mucositis prevalence were taken into consideration in each and every group...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29512846/progressive-multifocal-leukoencephalopathy-after-allogeneic-stem-cell-transplantation-case-report-and-review-of-the-literature
#11
Cai Yuan, Candace Deberardinis, Rushang Patel, Seema M Shroff, Steven A Messina, Steven Goldstein, Shahram Mori
Progressive multifocal leukoencephalopathy (PML) is a rare, yet typically fatal complication of allogeneic stem cell transplantation. It is caused by reactivation of the John Cunningham (JC) virus in an immunocompromised host. This report describes an unfortunate case of PML in a recipient of an allogeneic stem cell transplant for acute myelogenous leukemia. The JC virus was undetectable in the patient's cerebrospinal fluid by polymerase chain reaction (PCR); however, a positive diagnosis was made after a brain biopsy...
March 7, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29419431/sequential-loss-of-tumor-surface-antigens-following-chimeric-antigen-receptor-t-cell-therapies-in-diffuse-large-b-cell-lymphoma
#12
LETTER
Haneen Shalabi, Ira L Kraft, Hao-Wei Wang, Constance M Yuan, Bonnie Yates, Cindy Delbrook, Julie D Zimbelman, Roger Giller, Maryalice Stetler-Stevenson, Elaine S Jaffe, Daniel W Lee, Jack F Shern, Terry J Fry, Nirali N Shah
No abstract text is available yet for this article.
May 2018: Haematologica
https://www.readbyqxmd.com/read/29415326/pediatric-acute-lymphoblastic-leukemia-proportion-of-patients-who-continue-hospital-visits
#13
Naoko Maeda, Akiko Saito, Akiko Kada, Toshihiko Imamura, Akira Hayakawa, Keizo Horibe, Atsushi Sato
BACKGROUND: Long-term follow up in adulthood after childhood cancer therapy is particularly important because of the risk of late effects, and information on the rate of continuing hospital visits by childhood cancer survivors (CCS) is also important for the planning of studies on the risk of late effects. METHODS: The rate of continuing hospital visits ("long-term follow up") in 1,252 cases registered in the multicenter Japan Association of Childhood Leukemia Study on Acute Lymphoblastic Leukemia (JACLS ALL-02) was investigated using data from its electronic data capture (EDC) system, including case number, date of diagnosis, date of therapy completion, date of birth, sex, survival or death, date of death, date of last outcome confirmation, and facility code...
February 7, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29406239/coagulopathic-side-effect-of-l-asparaginase-on-fibrinogen-level-in-childhood-acute-lymphoblastic-leukemia-during-induction-phase
#14
Alauldeen Mudhafar Zubair Alqasim, Raji Hussein Al-Hadithi, Aseel Nashaat Al-Khalidi
BACKGROUND: L-asparaginase is chemotherapeutic agent commonly used in treatment of Acute Lymphoblastic Leukemia. Thromboembolic and to a lesser extent bleeding events are serious complications associated with administration of this drug during the induction phase in ALL especially in children resulting from reduced synthesis of proteins such as Antithrombin & fibrinogen. OBJECTIVE: Evaluation of the coagulopathic side effect of L-asparaginase during the induction phase in treatment of ALL in children by measuring fibrinogen levels before & after administration of this drug...
February 1, 2018: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/29401514/patient-and-provider-experiences-with-active-surveillance-a-scoping-review
#15
REVIEW
Claire Kim, Frances C Wright, Nicole J Look Hong, Gary Groot, Lucy Helyer, Pamela Meiers, May Lynn Quan, Robin Urquhart, Rebecca Warburton, Anna R Gagliardi
OBJECTIVE: Active surveillance (AS) represents a fundamental shift in managing select cancer patients that initiates treatment only upon disease progression to avoid overtreatment. Given uncertain outcomes, patient engagement could support decision-making about AS. Little is known about how to optimize patient engagement for AS decision-making. This scoping review aimed to characterize research on patient and provider communication about AS, and associated determinants and outcomes. METHODS: MEDLINE, EMBASE, CINAHL, and The Cochrane Library were searched from 2006 to October 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29398801/neurocognitive-consequences-of-childhood-leukemia-and-its-treatment
#16
Ayşe Bozkurt Turhan, S Tülin Fidan, Coşkun Yarar, E Nazlı Sakallı, Zeynep Canan Özdemir, Özcan Bör
As survival rates have improved in pediatric patients with leukemia, late side effects from chemotherapeutics and radiotherapy have become important considerations. We investigated these side effects and evaluated their impact on neurocognitive functions. The observational study included 68 patients with acute leukemia who were treated at Eskisehir Osmangazi University Medical Faculty. The study also included 62 of the patients' closest age siblings as a control group. Demographic and clinical data, chemotherapy protocol, use of radiotherapy were recorded, neurological and ophthalmological examinations, cranial imaging, electroencephalography, visual evoked potential, and hearing investigations were performed, and neurocognitive functions were evaluated...
January 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29374563/does-the-use-of-melatonin-overcome-drug-resistance-in-cancer-chemotherapy
#17
REVIEW
Mohammad Hossein Asghari, Emad Ghobadi, Milad Moloudizargari, Marjan Fallah, Mohammad Abdollahi
Our knowledge regarding the implications of melatonin in the therapy of numerous medical conditions, including cancer is constantly expanding. Melatonin can variably affect cancer pathology via targeting several key aspects of any neoplastic condition, including the very onset of carcinogenesis as well as tumor growth, differentiation, and dissemination. Numerous studies have examined the effects of melatonin in the context of various cancers reporting the enhanced efficacy of chemo/radiotherapy in combination with this compound...
March 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29334369/dual-gene-activation-and-knockout-screen-reveals-directional-dependencies-in-genetic-networks
#18
Michael Boettcher, Ruilin Tian, James A Blau, Evan Markegard, Ryan T Wagner, David Wu, Xiulei Mo, Anne Biton, Noah Zaitlen, Haian Fu, Frank McCormick, Martin Kampmann, Michael T McManus
Understanding the direction of information flow is essential for characterizing how genetic networks affect phenotypes. However, methods to find genetic interactions largely fail to reveal directional dependencies. We combine two orthogonal Cas9 proteins from Streptococcus pyogenes and Staphylococcus aureus to carry out a dual screen in which one gene is activated while a second gene is deleted in the same cell. We analyze the quantitative effects of activation and knockout to calculate genetic interaction and directionality scores for each gene pair...
February 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29316888/the-preventive-effect-of-sensorimotor-and-vibration-exercises-on-the-onset-of-oxaliplatin-or-vinca-alkaloid-induced-peripheral-neuropathies-stop
#19
Fiona Streckmann, Maryam Balke, Helmar C Lehmann, Vanessa Rustler, Christina Koliamitra, Thomas Elter, Michael Hallek, Michael Leitzmann, Tilman Steinmetz, Petra Heinen, Freerk T Baumann, Wilhelm Bloch
BACKGROUND: Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected. CIPN is induced by neurotoxic chemotherapeutic agents and can manifest with sensory and/or motor deficits. It is associated with significant disability and poor recovery. Common symptoms include pain, altered sensation, reduced or absent reflexes, muscle weakness, reduced balance control and insecure gait...
January 10, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29296741/osteonecrosis-in-children-and-adolescents-with-acute-lymphoblastic-leukemia-a-therapeutic-challenge
#20
REVIEW
Michaela Kuhlen, Marina Kunstreich, Kathinka Krull, Roland Meisel, Arndt Borkhardt
Osteonecrosis (ON) represents one of the most common and debilitating sequelae of antileukemic treatment in children and adolescents with acute lymphoblastic leukemia (ALL). Systematic screening strategies can focus on early detection and intervention to prevent ON from progressing to stages associated with pain and functional impairment. These strategies hold promise for reducing ON-associated morbidity without the risk of impairing leukemia control. Herein, we critically reviewed clinical data on pharmacological, nonpharmacological/nonsurgical, and surgical (including cellular) treatment options for ON, which are covered in the literature and/or are conceivable based on the supposed underlying ON pathophysiology...
June 13, 2017: Blood Advances
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