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https://www.readbyqxmd.com/read/29913517/periradicular-infiltration-of-the-cervical-spine-how-new-ct-scanner-techniques-and-protocol-modifications-contribute-to-the-achievement-of-low-dose-interventions
#1
Fabian Henry Jürgen Elsholtz, Julia Evi-Katrin Kamp, Janis Lucas Vahldiek, Bernd Hamm, Stefan Markus Niehues
PURPOSE:  CT-guided periradicular infiltration of the cervical spine is an effective symptomatic treatment in patients with radiculopathy-associated pain syndromes. This study evaluates the robustness and safety of a low-dose protocol on a CT scanner with iterative reconstruction software. MATERIALS AND METHODS:  A total of 183 patients who underwent periradicular infiltration therapy of the cervical spine were included in this study. 82 interventions were performed on a new CT scanner with a new intervention protocol using an iterative reconstruction algorithm...
June 18, 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29913479/prioritizing-and-modelling-of-putative-drug-target-proteins-of-candida-albicans-by-systems-biology-approach
#2
Tariq Ismail, Nighat Fatima, Syed Aun Muhammad, Syed Saoud Zaidi, Nisar Rehman, Izhar Hussain, Najam Us Sahr Tariq, Imran Amirzada, Abdul Mannan
Candida albicans (Candida albicans) is one of the major sources of nosocomial infections in humans which may prove fatal in 30% of cases. The hospital acquired infection is very difficult to treat affectively due to the presence of drug resistant pathogenic strains, therefore there is a need to find alternative drug targets to cure this infection. In silico and computational level frame work was used to prioritize and establish antifungal drug targets of Candida albicans. The identification of putative drug targets was based on acquiring 5090 completely annotated genes of Candida albicans from available databases which were categorized into essential and non-essential genes...
2018: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/29913379/the-role-of-social-support-in-family-socio-economic-disparities-in-depressive-symptoms-during-early-pregnancy-evidence-from-a-chinese-birth-cohort
#3
Dong-Mei Wei, Shiu Lun Au Yeung, Jian-Rong He, Wan-Qing Xiao, Jin-Hua Lu, Si Tu, Nian-Nian Chen, Kin Bong Hubert Lam, Kar-Keung Cheng, Gabriel M Leung, Hui-Min Xia, C Mary Schooling, Xiu Qiu
BACKGROUND: Few studies have examined the association between a composite measure of family socio-economic position (SEP)2 and depressive symptoms among Chinese pregnant women, nor any potential underlying mechanisms which may be amenable to preventative interventions. METHODS: We investigated the association between a composite SEP measure and depressive symptoms during early pregnancy, and tested for mediation by social support and moderation by parity in the Born in Guangzhou Cohort Study (n = 12,382) using adjusted logistic regression and causal mediation analysis...
June 5, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29913351/shedding-light-on-the-association-between-repetitive-negative-thinking-and-deficits-in-cognitive-control-a-meta-analysis
#4
REVIEW
Ulrike Zetsche, Paul-Christian Bürkner, Lars Schulze
Individuals who experience recurrent negative thoughts are at elevated risk for mood and anxiety disorders. It is thus essential to understand why some individuals get stuck in recurrent negative thinking (RNT), whereas others are able to disengage eventually. Theoretical models propose that individuals high in recurrent negative thinking suffer from deficits in controlling the contents of working memory. Empirical findings, however, are inconclusive. In this meta-analysis, we synthesize findings from 94 studies to examine the proposed association between RNT and deficits in cognitive control...
June 11, 2018: Clinical Psychology Review
https://www.readbyqxmd.com/read/29913348/from-linear-care-plan-through-concept-map-to-concepto-plan-the-creation-of-an-innovative-and-holistic-care-plan
#5
M Sherry McDonald, Melanie Neumeier, Mark E Olver
Linear care plans have traditionally been used in nursing education to support nursing students in identifying potential and actual health care problems, and to follow up on those issues with nursing interventions. However, the linear care plan does not support the nursing student with learning in-depth critical thinking, clinical reasoning, creative thinking, and other ways of thinking. Concept mapping was introduced as a way to support the nursing student to improve upon critical thinking and clinical reasoning and to identify relationships among the patient's health care problems...
May 26, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29913345/variation-in-and-factors-associated-with-psychosocial-interventions-for-hospitalised-self-harm-patients-in-new-south-wales-australia
#6
Wei Du, Matt Luther, Jane Desborough, Mark Rogalewicz, Nicholas Glasgow
OBJECTIVE: Psychosocial interventions demonstrate benefits during care for self-harm patients, however their adoption in hospital care remain largely unknown. This study aimed to evaluate the variation in and factors associated with psychosocial intervention use when treating self-harm patients at New South Wales (NSW) public hospitals. METHOD: We used the all-inclusive NSW Admitted Patient Data from July 2001 to June 2014. The primary outcome was receipt of hospital based psychosocial intervention...
June 12, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29913318/the-evidence-needed-to-demonstrate-impact-a-synthesis-of-the-evidence-from-a-phased-social-and-emotional-wellbeing-intervention
#7
Leigh-Ann Onnis, Helen Klieve, Komla Tsey
Policy decisions are based on evidence that demonstrates the effectiveness of interventions; however, the quantity and type of evidence that is needed to demonstrate the effectiveness of an intervention is not universally agreed upon. The aim of this study was to collaborate with researchers who have not been involved directly in Family Wellbeing interventions to lead a review of characteristics of the Family Wellbeing intervention evaluation output to date, and to assess for evidence of the FWB intervention's impact on participants and their communities...
May 31, 2018: Evaluation and Program Planning
https://www.readbyqxmd.com/read/29913297/zoonoses-under-our-noses
#8
Alice R Cross, Victoria M Baldwin, Sumita Roy, Angela E Essex-Lopresti, Joann L Prior, Nicholas J Harmer
One Health is an effective approach for the management of zoonotic disease in humans, animals and environments. Examples of the management of bacterial zoonoses in Europe and across the globe demonstrate that One Health approaches of international surveillance, information-sharing and appropriate intervention methods are required to successfully prevent and control disease outbreaks in both endemic and non-endemic regions. Additionally, a One Health approach enables effective preparation and response to bioterrorism threats...
June 15, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29913256/the-effect-of-glucocorticoids-on-bone-mineral-density-in-patients-with-rheumatoid-arthritis-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#9
Anne-Birgitte Blavnsfeldt, Annette de Thurah, Malissa Dawn Thomsen, Simon Tarp, Bente Langdahl, Ellen-Margrethe Hauge
PURPOSE: The role of glucocorticoids in the treatment of rheumatoid arthritis (RA) is widely debated. Impairment of bone formation may be counter-balanced by reduced systemic inflammation. This review aims to assess the effect of prednisolone/prednisone on bone mineral density (BMD) in patients with RA analyzed in randomized, controlled trials. METHODS: We performed a systematic literature search and identified randomized, double-blinded placebo-controlled studies including patients with RA and using prednisolone or prednisone as the intervention...
June 15, 2018: Bone
https://www.readbyqxmd.com/read/29913227/effects-of-bright-light-exposure-on-human-fear-conditioning-extinction-and-associated-prefrontal-activation
#10
Takuya Yoshiike, Motoyasu Honma, Naoto Yamada, Yoshiharu Kim, Kenichi Kuriyama
Bright light (BL) not only regulates human emotion and circadian physiology but can also directly modulate emotional memories. Impaired fear extinction and enhanced fear acquisition and consolidation are hallmarks of fear-circuitry disorders; thus, we tested whether BL facilitates fear extinction and inhibits fear acquisition. We randomly exposed 29 healthy humans to high- (9000 lx) or low-intensity light (<500 lx) for 15 min, near the nadir of the phase response to light, in a single-blind manner...
June 15, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29913174/low-dose-aspirin-is-associated-with-reduced-spontaneous-preterm-birth-in-nulliparous-women
#11
Maria Andrikopoulou, Stephanie E Purisch, Roxane Handal-Orefice, Cynthia Gyamfi-Bannerman
BACKGROUND: Preterm birth (PTB) is one of the leading causes of perinatal morbidity and mortality. Clinical data suggests that low dose aspirin may decrease the rate of overall PTB, but investigators have speculated that this is likely due to a decrease in medically indicated PTB through its effect on the incidence of preeclampsia and other placental disease. We hypothesized that low dose aspirin may also impact the mechanism of spontaneous preterm labor. OBJECTIVE: Our objective was to determine whether low dose aspirin reduces the rate of spontaneous PTB in nulliparous women without medical co-morbidities...
June 15, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29913088/development-of-therapist-adherence-in-relation-to-treatment-outcomes-of-adolescents-with-behavioral-problems
#12
Aurelie M C Lange, Rachel E A van der Rijken, Marc J M H Delsing, Jan J V Busschbach, Ron H J Scholte
Therapist adherence to the treatment manual is assumed to be crucial for adequate implementation and subsequent achievement of the intended, positive treatment outcomes. Although adherence has been mostly studied as a static factor, recent studies suggest that adherence might be dynamic and changes over time. We investigated how parent-perceived adherence to the multisystemic therapy (MST) model develops during treatment and how this development is related to treatment outcomes up to 18 months posttreatment, controlling for the effect of alliance...
June 18, 2018: Journal of Clinical Child and Adolescent Psychology
https://www.readbyqxmd.com/read/29913081/anxiety-management-participants-experiences-of-a-physiotherapeutic-group-treatment-in-swedish-psychiatric-outpatient-care
#13
Helena Ölund, Louise Danielsson, Susanne Rosberg
Anxiety disorders are among the most persistent mental health syndromes. There is extensive research showing effectiveness of pharmacotherapy and psychotherapy interventions targeting anxiety, while knowledge is still sparse for other treatment options. The aim of this study was to explore how participants with anxiety disorders experience a physiotherapeutic group treatment in psychiatric outpatient care, and their perceived ability to manage anxiety within two months after participating in the treatment. Semi-structured interviews with participants were conducted to explore experiences of the treatment...
June 18, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29913020/effect-of-tamsulosin-on-passage-of-symptomatic-ureteral-stones-a-randomized-clinical-trial
#14
Andrew C Meltzer, Pamela Katzen Burrows, Allan B Wolfson, Judd E Hollander, Michael Kurz, Ziya Kirkali, John W Kusek, Patrick Mufarrij, Stephen V Jackman, Jeremy Brown
Importance: Urinary stone disease is a common presentation in the emergency department, and α-adrenergic receptor blockers, such as tamsulosin, are commonly used to facilitate stone passage. Objective: To determine if tamsulosin promotes the passage of urinary stones within 28 days among emergency department patients. Design, Setting, and Participants: We conducted a double-blind, placebo-controlled clinical trial from 2008 to 2009 (first phase) and then from 2012 to 2016 (second phase)...
June 18, 2018: JAMA Internal Medicine
https://www.readbyqxmd.com/read/29912966/adenosine-a1-receptor-a-neuroprotective-target-in-light-induced-retinal-degeneration
#15
Manuel Soliño, Ester María López, Manuel Rey-Funes, César Fabián Loidl, Ignacio M Larrayoz, Alfredo Martínez, Elena Girardi, Juan José López-Costa
Light induced retinal degeneration (LIRD) is a useful model that resembles human retinal degenerative diseases. The modulation of adenosine A1 receptor is neuroprotective in different models of retinal injury. The aim of this work was to evaluate the potential neuroprotective effect of the modulation of A1 receptor in LIRD. The eyes of rats intravitreally injected with N6-cyclopentyladenosine (CPA), an A1 agonist, which were later subjected to continuous illumination (CI) for 24 h, showed retinas with a lower number of apoptotic nuclei and a decrease of Glial Fibrillary Acidic Protein (GFAP) immunoreactive area than controls...
2018: PloS One
https://www.readbyqxmd.com/read/29912954/impact-of-smartphone-assisted-prenatal-home-visits-on-women-s-use-of-facility-delivery-results-from-a-cluster-randomized-trial-in-rural-tanzania
#16
Kristy Hackett, Curtis Lafleur, Peter Nyella, Ophira Ginsburg, Wendy Lou, Daniel Sellen
BACKGROUND: About half of births in rural Tanzania are assisted by skilled providers. Point-of-care mobile phone applications hold promise in boosting job support for community health workers aiming to ensure safe motherhood through increased facility delivery awareness, access and uptake. We conducted a controlled comparison to evaluate a smartphone-based application designed to assist community health workers with data collection, education delivery, gestational danger sign identification, and referrals...
2018: PloS One
https://www.readbyqxmd.com/read/29912918/girls-only-vs-mixed-gender-groups-in-the-delivery-of-a-universal-wellness-programme-among-adolescents-a-cluster-randomized-controlled-trial
#17
Reut Agam-Bitton, Wiessam Abu Ahmad, Moria Golan
BACKGROUND: Investigation of the optimal setting for body image prevention programmes is important to maximize the outcomes of such programmes. OBJECTIVES: We examined the preferred setting for a school-based wellness programme called "In Favour of Myself". METHODS: A total of 259 girls (mean 13.82±0.64 years) were divided into a girls-only intervention group, a mixed-gender intervention and a waiting list control group. The participants completed self-report questionnaires at baseline, post-intervention (2 months) and at follow-up (3 months) examining changes in self-esteem, media literacy, body image and risk factors for eating disorders...
2018: PloS One
https://www.readbyqxmd.com/read/29912814/factors-associated-with-hiv-infection-among-female-sex-workers-in-brazil
#18
Célia Landmann Szwarcwald, Giseli Nogueira Damacena, Paulo Roberto Borges de Souza-Júnior, Mark Drew Crosland Guimarães, Wanessa da Silva de Almeida, Arthur Pate de Souza Ferreira, Orlando da Costa Ferreira-Júnior, Inês Dourado
BACKGROUND: Female sex workers (FSWs) are one of the most-at-risk population groups for human immunodeficiency virus (HIV) infection. This paper aims at identifying the main predictors of HIV infection among FSW recruited in the 2nd Biological and Behavioral Surveillance Survey in 12 Brazilian cities in 2016. METHOD: Data were collected on 4245 FSW recruited by respondent driven sampling (RDS). Weights were inversely proportional to participants' network sizes. To establish the correlates of HIV infection, we used logistic regression models taking into account the dependence of observations resultant from the recruitment chains...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29912757/dietary-interventions-in-liver-cirrhosis
#19
Chu Kion Yao, James Fung, Natural Hoi Sing Chu, Victoria Ping Yi Tan
Liver cirrhosis is associated with significant nutritional risks that often result in serious hepatic complications and poor survival rates. Diet is an important but underutilized aspect in the treatment modality of cirrhosis. Therefore, the aims of this review are to ascertain nutritional risks associated with its pathophysiology and to summarize existing evidence that support dietary recommendations for managing this patient population. Alterations in substrate utilization for energy production is a main feature of liver cirrhosis, resulting in increased catabolism of protein stores and a predisposition toward protein-energy malnutrition, even in the early stages of the disease...
June 16, 2018: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29912727/ultrasound-imaging-for-sarcopenia-spasticity-and-painful-muscle-syndromes
#20
Levent Özçakar, Ayşe Merve Ata, Bayram Kaymak, Murat Kara, Dinesh Kumbhare
PURPOSE OF REVIEW: On the basis of its various advantages and the relevant awareness of physicians, ultrasound imaging has overwhelmingly taken its place in the scientific arena. This is true both from the side of daily clinical applications and also from the side of research. Yet, ultrasound provides real-time (diagnostic) imaging and (interventional) guidance for a wide spectrum of muscle disorders. In this regard, this review aims to discuss the potential/actual utility of ultrasound imaging in particular muscle disorders, that is, sarcopenia, spasticity and fibromyalgia/myofascial pain syndrome...
June 15, 2018: Current Opinion in Supportive and Palliative Care
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