keyword
MENU ▼
Read by QxMD icon Read
search

Cmv

keyword
https://www.readbyqxmd.com/read/29474231/clinical-and-serological-predictors-of-suicide-in-schizophrenia-and-major-mood-disorders
#1
Faith Dickerson, Andrea Origoni, Lucy A B Schweinfurth, Cassie Stallings, Christina L G Savage, Kevin Sweeney, Emily Katsafanas, Holly C Wilcox, Sunil Khushalani, Robert Yolken
Persons with serious mental illness are at high risk for suicide, but this outcome is difficult to predict. Serological markers may help to identify suicide risk. We prospectively assessed 733 persons with a schizophrenia spectrum disorder, 483 with bipolar disorder, and 76 with major depressive disorder for an average of 8.15 years. The initial evaluation consisted of clinical and demographic data as well as a blood samples from which immunoglobulin G antibodies to herpes viruses and Toxoplasma gondii were measured...
March 2018: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/29474137/pcr-multiplex-for-cmv-detection-in-patients-with-anterior-uveitis
#2
Alexandra Martín Ramírez, Laura Cardeñoso Domingo, J Jacobo González Guijarro
PURPOSE: Describing the utility of Polymerase Chain Reaction for Cytomegalovirus (CMV-PCR) in the diagnosis of suspected viral anterior uveitis (AU). PATIENTS AND METHODS: We analyzed aqueous humor (AH) CMV-PCR positivity and treatment modifications in 47 eyes of 46 patients with viral uveitis and its correlation with high intraocular pressure (HIOP), uveitis clinical characteristics and time intervals from samples to uveitis diagnosis and to relapse. RESULTS: CMV-PCR positive results occurred in 13 eyes (27...
February 23, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29471326/urinary-cytomegalovirus-shedding-in-the-united-states-the-national-health-and-nutrition-examination-surveys-1999-2004
#3
Minal M Amin, Stephanie R Bialek, Sheila C Dollard, Chengbin Wang
Background: There are no data on the prevalence of cytomegalovirus (CMV) shedding from a representative sample of the US population. This information is critical for understanding and preventing CMV. Methods: We tested urine specimens from CMV IgG-positive participants aged 6-49 years in three racial/ethnic groups from the National Health and Nutrition Examination Surveys (NHANES) 1999-2004 for the presence of CMV DNA with real-time polymerase chain reaction (PCR) assay...
February 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29467963/new-extracellular-factors-in-glioblastoma-multiforme-development-neurotensin-growth-differentiation-factor-15-sphingosine-1-phosphate-and-cytomegalovirus-infection
#4
REVIEW
Jan Korbecki, Izabela Gutowska, Ireneusz Kojder, Dariusz Jeżewski, Marta Goschorska, Agnieszka Łukomska, Anna Lubkowska, Dariusz Chlubek, Irena Baranowska-Bosiacka
Recent years have seen considerable progress in understanding the biochemistry of cancer. For example, more significance is now assigned to the tumor microenvironment, especially with regard to intercellular signaling in the tumor niche which depends on many factors secreted by tumor cells. In addition, great progress has been made in understanding the influence of factors such as neurotensin, growth differentiation factor-15 (GDF-15), sphingosine-1-phosphate (S1P), and infection with cytomegalovirus (CMV) on the 'hallmarks of cancer' in glioblastoma multiforme...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29465841/permanent-childhood-hearing-impairment-aetiological-evaluation-of-infants-identified-through-the-irish-newborn-hearing-screening-programme
#5
A Smith, A O'Connor, S Hennessy, P G O'Sullivan, L Gibson
The Newborn Hearing Screening Programme (NHSP) was established in Cork University Maternity Hospital (CUMH) in April 2011. Between April 2011 and July 2014, 42 infants were identified with a Permanent Childhood Hearing Impairment (PCHI). Following this diagnosis, infants underwent a paediatric assessment according to recognised guidelines with the intention of identifying the underlying aetiology of the PCHI. The aim of this study was to assess the findings of this aetiological workup via retrospective chart review...
December 18, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29465561/cross-sectional-study-of-cd4-cd8-ratio-recovery-in-young-adults-with-perinatally-acquired-hiv-1-infection
#6
Katrina M Pollock, Hannah Pintilie, Caroline Foster, Sarah Fidler
Antiretroviral therapy (ART) has improved survival into adulthood for young people with perinatally acquired HIV-1 (yp-PaHIV), but long-term prognosis remains unclear. We hypothesized that on-going immune activation, reflected in the failure of CD4:CD8 ratio normalization would be observed in yp-PaHIV, despite ART.A cross-sectional study of routinely collected clinical data from a cohort of yp-PaHIV (≥16 years).Data were collected from records of individuals attending a specialist clinic for yp-PaHIV transitioning to adult care...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29463426/comparison-of-two-commercial-quantitative-pcr-assays-and-correlation-with-the-first-who-international-standard-for-human-cmv
#7
Ilka Engelmann, Enagnon Kazali Alidjinou, Mouna Lazrek, Judith Ogiez, Jean-Marie Pouillaude, Emmanuel Chazard, Anny Dewilde, Didier Hober
Comparability between CMV assays could be facilitated by the first WHO International Standard for human CMV (standard). Standard dilutions were submitted to nucleic acid extraction with Versant kPCR Molecular systems SP or MagNA Pure LC System followed by the kPCR PLX™ CMV DNA (kPCR) or the CMV R-gene™ assay (R-gene), respectively; 139 clinical specimens were tested. Both assays correlated well with the standard (R2 > 0.96) and a matrix effect was observed. Quantitative results correlated reasonably between both assays for whole blood (R2 = 0...
January 7, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29459261/the-immune-response-to-cmv-infection-and-vaccination-in-mice-monkeys-and-humans-recent-developments
#8
REVIEW
Ann B Hill
The immune response to CMV is characterized by extremely large T cell and antibody responses that persist for a lifetime, but do not prevent superinfection with other CMV strains. This makes generation of a vaccine against CMV very difficult, but has facilitated development of CMV-vectored vaccines, which have shown promise in mouse tumor models and in monkey models of infectious disease. The serendipitous use of a mutant rhesus CMV vector for the SIV vaccine elicited extraordinary, CD8 T cell responses restricted by MHCII and non-classical MHCI molecules which apparently provide protection against SIV...
February 16, 2018: Current Opinion in Virology
https://www.readbyqxmd.com/read/29459054/a-case-of-late-onset-cytomegalovirus-myocarditis-in-an-orthotopic-heart-transplant-recipient-case-report-and-review-of-the-literature
#9
Ruben Mylvaganam, Allison Glaser, Noah Moss, Meenakshi Rana
We describe a male patient who presents 2 years posttransplant with cough and dyspnea. A negative pulmonary workup led to an endomyocardial biopsy and the diagnosis of cytomegalovirus (CMV) myocarditis. The patient was treated with ganciclovir and intravenous immunoglobulin. This illustrates a very late presentation of posttransplant CMV myocarditis and the usefulness of myocardial biopsy in diagnosis of CMV carditis.
January 31, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29457490/demonstration-of-resistant-or-wild-type-virus-in-recurrent-viremia-after-ganciclovir-resistant-cytomegaloviral-infection
#10
Margaret R Jorgenson, Jillian L Descourouez, Robert R Redfield, Jeannina A Smith, Didier A Mandelbrot
BACKGROUND: Ganciclovir-resistant cytomegalovirus (GR-CMV) is a serious complication of transplantation. Recurrence after primary infection is common. Little is known about CMV drug resistance and latency. OBJECTIVE: Review CMV genotype during episodes of recurrent CMV viremia after prior documentation of ganciclovir resistance to evaluate if resistance is redemonstrated. METHODS: All adult transplant recipients with history of GR-CMV viremia from January 1, 2011, to December 31, 2015, were screened; those with subsequent laboratory evidence of recurrent CMV viremia and genotyping were included...
February 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29456530/donor-genotype-in-the-interleukin-7-receptor-%C3%AE-chain-predicts-risk-of-graft-versus-host-disease-and-cytomegalovirus-infection-after-allogeneic-hematopoietic-stem-cell-transplantation
#11
Katrine Kielsen, Christian Enevold, Carsten Heilmann, Henrik Sengeløv, Anders Elm Pedersen, Lars P Ryder, Klaus Müller
The efficacy of allogeneic hematopoietic stem cell transplantation (HSCT) is challenged by acute and chronic graft-versus-host disease (aGVHD and cGVHD) and viral infections due to long-lasting immunodeficiency. Interleukin-7 (IL-7) is a cytokine essential for de novo T cell generation in thymus and peripheral T cell homeostasis. In this study, we investigated the impact of the single nucleotide polymorphism rs6897932 in the IL-7 receptor α-chain (IL-7Rα) which has previously been associated with several autoimmune diseases...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29456230/isolated-renal-involvement-of-cytomegalovirus-inclusion-disease-in-an-infant
#12
Subramaniam Murugananth, Rajendran Padmaraj, Natarajan Gopalakrishnan, Rajendran Manorajan, Anila Abraham Kurien, Jeyachandran Dhanapriya, Thanigachalam Dineshkumar, Ramanathan Sakthirajan
Cytomegalovirus (CMV) is the most common cause of congenital infections in humans occurring in 1% of all liveborns. Symptomatic congenital CMV infection involves multiple systems and causes significant morbidity and mortality in newborns. Isolated CMV infection of the kidneys in a living infant has not been reported in literature. Here, we report an infant who presented only with renomegaly and renal biopsy showed extensive CMV inclusions. Serum and urine polymerase chain reaction for CMV were positive, and CMV involvement of other organs was ruled out...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456214/outcome-of-renal-transplant-recipients-with-cytomegalovirus-and-bk-polyomavirus-co-infection-nephropathy
#13
Anupma Kaul, Shashi Kumar, Dharmendra Bhaduaria, Vinita Agrawal, R K Sharma, Narayan Prasad, Amit Gupta, Rishi Kumar
Reactivation of cytomegalovirus (CMV) and BK polyomavirus (BKV) can result in virus-associated tubulointerstitial nephritis in renal allografts. All those renal biopsies reported as viral cytopathic were isolated and examined by two independent renal histopathologists from our institute and classified as CMV, BKV, and CMV-BKV coinfection-associated viral cytopathic changes with confirmation through polymerase chain reaction technology in either serum or urine or both. All twenty patients were categorized as 10 in CMV, four in BKV, and six were in CMV-BKV coinfection...
January 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29456015/multi-antigenic-human-cytomegalovirus-mrna-vaccines-that-elicit-potent-humoral-and-cell-mediated-immunity
#14
Shinu John, Olga Yuzhakov, Angela Woods, Jessica Deterling, Kimberly Hassett, Christine A Shaw, Giuseppe Ciaramella
A cytomegalovirus (CMV) vaccine that is effective at preventing congenital infection and reducing CMV disease in transplant patients remains a high priority as no approved vaccines exist. While the precise correlates of protection are unknown, neutralizing antibodies and antigen-specific T cells have been implicated in controlling infection. We demonstrate that the immunization of mice and nonhuman primates (NHPs) with lipid nanoparticles (LNP) encapsulating modified mRNA encoding CMV glycoproteins gB and pentameric complex (PC) elicit potent and durable neutralizing antibody titers...
February 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29455458/diagnosis-presentation-and-initial-severity-of-autoimmune-hepatitis-aih-in-patients-attending-28-hospitals-in-the-uk
#15
Victoria Gordon, Ratul Adhikary, Victoria Appleby, Debasis Das, James Day, Toby Delahooke, Selena Dixon, David Elphick, Claire Hardie, Barbara Hoeroldt, Patricia Hooper, John Hutchinson, Rebecca Jones, Faisal Khan, Guruprasad P Aithal, John McGonigle, Andrew Nelson, Alick Nkhoma, Stavroula Pelitari, Martin Prince, Annell Prosser, Vinay Sathanarayana, Sophia Savva, Naina Shah, Sushma Saksena, Sreedhari Thayalasekaran, Deven Vani, Andrew Yeoman, Dermot Gleeson
BACKGROUND AND AIMS: There is limited information regarding patients with AIH outside relatively few large centres. We describe here the presenting features of patients with AIH, collected as part of an audit involving 28 UK hospitals. METHODS: Patients (incident since 1/1/2007 or prevalent since 1/1/2000) were >18 years and either met 1999 International AIH Group (IAIHG) diagnostic criteria (n=1164), or received immunosuppressive therapy for clinically diagnosed AIH (n=103)...
February 17, 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29454849/escmid-study-group-for-infections-in-compromised-hosts-esgich-consensus-document-on-the-safety-of-targeted-and-biological-therapies-an-infectious-diseases-perspective-intracellular-signaling-pathways-tyrosine-kinase-and-mtor-inhibitors
#16
REVIEW
Mark Reinwald, Jose T Silva, Nicolas J Mueller, Jesús Fortún, Christian Garzoni, Johan W de Fijter, Mario Fernández-Ruiz, Paolo Grossi, Jose María Aguado
BACKGROUND: The present review is part of the ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies. AIMS: To review, from an Infectious Diseases perspective, the safety profile of therapies targeting different intracellular signaling pathways and to suggest preventive recommendations. SOURCES: Computer-based MEDLINE searches with MeSH terms pertaining to each agent or therapeutic family...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29447718/no-240-cytomegalovirus-infection-in-pregnancy
#17
Yoav Yinon, Dan Farine, Mark H Yudin
OBJECTIVES: To review the principles of prenatal diagnosis of congenital cytomegalovirus (CMV) infection and to describe the outcomes of the affected pregnancies. OUTCOMES: Effective management of fetal infection following primary and secondary maternal CMV infection during pregnancy. Neonatal signs include intrauterine growth restriction (IUGR), microcephaly, hepatosplenomegaly, petechiae, jaundice, chorioretinitis, thrombocytopenia and anemia, and long-term sequelae consist of sensorineural hearing loss, mental retardation, delay of psychomotor development, and visual impairment...
February 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29447367/endometrial-natural-killer-nk-cells-reveal-a-tissue-specific-receptor-repertoire
#18
D Feyaerts, T Kuret, B van Cranenbroek, S van der Zeeuw-Hingrez, O W H van der Heijden, A van der Meer, I Joosten, R G van der Molen
STUDY QUESTION: Is the natural killer (NK) cell receptor repertoire of endometrial NK (eNK) cells tissue-specific? SUMMARY ANSWER: The NK cell receptor (NKR) expression profile in pre-pregnancy endometrium appears to have a unique tissue-specific phenotype, different from that found in NK cells in peripheral blood, suggesting that these cells are finely tuned towards the reception of an allogeneic fetus. WHAT IS KNOWN ALREADY: NK cells are important for successful pregnancy...
February 13, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29447285/murine-cytomegalovirus-degrades-mhc-class-ii-to-colonize-the-salivary-glands
#19
Joseph Yunis, Helen E Farrell, Kimberley Bruce, Clara Lawler, Stine Sidenius, Orry Wyer, Nicholas Davis-Poynter, Philip G Stevenson
Cytomegaloviruses (CMVs) persistently and systemically infect the myeloid cells of immunocompetent hosts. Persistence implies immune evasion, and CMVs evade CD8+ T cells by inhibiting MHC class I-restricted antigen presentation. Myeloid cells can also interact with CD4+ T cells via MHC class II (MHC II). Human CMV (HCMV) attacks the MHC II presentation pathway in vitro, but what role this evasion might play in host colonization is unknown. We show that Murine CMV (MCMV) down-regulates MHC II via M78, a multi-membrane spanning viral protein that captured MHC II from the cell surface and was necessary although not sufficient for its degradation in low pH endosomes...
February 15, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29445945/spectral-domain-optical-coherence-tomography-and-fundus-autofluorescence-findings-in-cytomegalovirus-retinitis-in-hiv-infected-patients
#20
Shigeko Yashiro, Takeshi Nishijima, Yuuka Yamamoto, Yumi Sekine, Natsuyo Yoshida-Hata, Tomohiro Iida, Shinichi Oka
PURPOSE: To assess the usefulness of spectral domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) findings in cytomegalovirus (CMV) retinitis. STUDY DESIGN: Observational case series. METHODS: Thirteen eyes of 11 human immunodeficiency virus (HIV)-positive patients with CMV retinitis underwent full ophthalmologic examinations, SD-OCT, and 4 eyes of 4 patients underwent FAF. FAF images included short-wavelength autofluorescence (SW-AF) and near-infrared autofluorescence (IR-AF)...
February 14, 2018: Japanese Journal of Ophthalmology
keyword
keyword
6658
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"