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Aging epidemiology

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https://www.readbyqxmd.com/read/28324921/epidemiology-of-intracranial-metastases-in-korea-a-national-cohort-investigation
#1
Tackeun Kim, Changhoon Song, Jung Ho Han, In-Ah Kim, Yu Jung Kim, Se Hyun Kim, Jee Hyun Kim, Chae-Yong Kim
Purpose: To investigate the epidemiologic features of intracranial metastases (ICMET) in Korea, we performed a cohort study using the National Health Insurance Service-National Sample Cohort database, which comprised healthcare usage information of approximately 1 million Korean individuals over 12 years. Materials and Methods: We enrolled 998,602 subjects, after excluding 18,218 subjects diagnosed with any cancer during the washout period (2002-2004). The observation period was 9 years (2005-2013; 8,725,438 person-years)...
March 21, 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/28324321/structured-data-entry-in-the-electronic-medical-record-perspectives-of-pediatric-specialty-physicians-and-surgeons
#2
Ruth A Bush, Cynthia Kuelbs, Julie Ryu, Wen Jiang, George Chiang
The Epic electronic health record (EHR) platform supports structured data entry systems (SDES), which allow developers, with input from users, to create highly customized patient-record templates in order to maximize data completeness and to standardize structure. There are many potential advantages of using discrete data fields in the EHR to capture data for secondary analysis and epidemiological research, but direct data acquisition from clinicians remains one of the largest obstacles to leveraging the EHR for secondary use...
May 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28323992/quantification-of-thyroid-cancer-and-multinodular-goiter-risk-in-the-dicer1-syndrome-a-family-based-cohort-study
#3
Nicholas E Khan, Andrew J Bauer, Kris Ann P Schultz, Leslie Doros, Rosamma M Decastro, Alexander Ling, Maya B Lodish, Laura A Harney, Ron G Kase, Ann G Carr, Christopher T Rossi, Amanda Field, Anne K Harris, Gretchen M Williams, Louis P Dehner, Yoav H Messinger, D Ashley Hill, Douglas R Stewart
Context: The risk of thyroid cancer and multinodular goiter (MNG) in the DICER1 syndrome, a rare tumor-predisposition disorder, is unknown. Objective: To quantify the risk of thyroid cancer and MNG in individuals with the DICER1 syndrome. Design: Family-based cohort study. Setting: National Institutes of Health (NIH) Clinical Center (CC). Participants: The National Cancer Institute DICER1 syndrome cohort consisted of 145 individuals with a DICER1 germline mutation and 135 family controls from 48 families...
February 2, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28323855/etiology-of-acute-diarrhea-in-the-elderly-in-china-a-six-year-observational-study
#4
Zike Zhang, Shengjie Lai, Jianxing Yu, Qibin Geng, Wanqi Yang, Yu Chen, Jianguo Wu, Huaiqi Jing, Weizhong Yang, Zhongjie Li
Acute diarrhea leads to a substantial disease burden among the elderly worldwide. However, in the context of increasingly aging trend in China, the prevalence of etiological agents among elderly diarrheal patients was undetermined. This study aimed to explore the major enteropathogens of acute diarrhea among outpatients older than 65 years in China, and also the epidemiological features of the pathogens. Demographic and clinical data for acute diarrhea among outpatients older than 65 years were collected from 213 participating hospitals from 2009 to 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28323831/genetic-assessment-of-age-associated-alzheimer-disease-risk-development-and-validation-of-a-polygenic-hazard-score
#5
Rahul S Desikan, Chun Chieh Fan, Yunpeng Wang, Andrew J Schork, Howard J Cabral, L Adrienne Cupples, Wesley K Thompson, Lilah Besser, Walter A Kukull, Dominic Holland, Chi-Hua Chen, James B Brewer, David S Karow, Karolina Kauppi, Aree Witoelar, Celeste M Karch, Luke W Bonham, Jennifer S Yokoyama, Howard J Rosen, Bruce L Miller, William P Dillon, David M Wilson, Christopher P Hess, Margaret Pericak-Vance, Jonathan L Haines, Lindsay A Farrer, Richard Mayeux, John Hardy, Alison M Goate, Bradley T Hyman, Gerard D Schellenberg, Linda K McEvoy, Ole A Andreassen, Anders M Dale
BACKGROUND: Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction. METHODS AND FINDINGS: Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of Alzheimer's Project (IGAP Stage 1), we identified AD-associated SNPs (at p < 10-5)...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28323829/potentially-modifiable-lifestyle-factors-cognitive-reserve-and-cognitive-function-in-later-life-a-cross-sectional-study
#6
Linda Clare, Yu-Tzu Wu, Julia C Teale, Catherine MacLeod, Fiona Matthews, Carol Brayne, Bob Woods
BACKGROUND: Potentially modifiable lifestyle factors may influence cognitive health in later life and offer potential to reduce the risk of cognitive decline and dementia. The concept of cognitive reserve has been proposed as a mechanism to explain individual differences in rates of cognitive decline, but its potential role as a mediating pathway has seldom been explored using data from large epidemiological studies. We explored the mediating effect of cognitive reserve on the cross-sectional association between lifestyle factors and cognitive function in later life using data from a population-based cohort of healthy older people...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28323666/febrile-infant-update
#7
Kate Dorney, Richard G Bachur
PURPOSE OF REVIEW: The approach to febrile young infants remains challenging. This review serves as an update on the care of febrile infants less than 90 days of age with a focus on the changing epidemiology of serious bacterial infection (SBI), refinement of management strategies based on biomarkers, and the development of novel diagnostics. RECENT FINDINGS: There is high variability in the emergency department management of febrile young infants without significant differences in outcomes...
March 20, 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28323645/pediatric-multiple-sclerosis
#8
Anusha K Yeshokumar, Sona Narula, Brenda Banwell
PURPOSE OF REVIEW: This review discusses the epidemiologic factors involved in the pathogenesis of pediatric multiple sclerosis (MS), which have been the focus of numerous studies in the last several years. We also review the clinical features (including diagnostic evaluation and differential diagnosis) of, treatment approach to, and prognosis of pediatric MS. RECENT FINDINGS: Up to 10% of patients with MS have their initial demyelinating before the age of 18 years...
March 20, 2017: Current Opinion in Neurology
https://www.readbyqxmd.com/read/28323524/comparison-of-two-predictive-models-for-short-term-mortality-in-patients-after-severe-traumatic-brain-injury
#9
Klara Julia Kesmarky, Cécile Delhumeau, Marie Zenobi, Bernhard Walder
The Glasgow Coma Scale (GCS) and the abbreviated injury score of the head region (HAIS) are validated prognostic factors in traumatic brain injury (TBI). The aim of this study was to compare the prognostic performance of an alternative predictive model including motor GCS, pupillary reactivity, age, HAIS, and presence of multi-trauma for short term mortality with a reference predictive model including motor GCS, pupil reaction and age (IMPACT core model). A secondary analysis of a prospective epidemiological cohort study in Switzerland including patients after severe TBI (HAIS >3) with the outcome death at 14 days was performed...
March 21, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28323463/injury-mortality-in-individuals-with-autism
#10
Joseph Guan, Guohua Li
OBJECTIVES: To examine epidemiological patterns of injury fatalities in individuals with a diagnosis of autism. METHODS: We identified individuals with a diagnosis of autism who died between 1999 and 2014 by screening causes of death in the multiple cause-of-death data files in the National Vital Statistics System based on the International Classification of Diseases, 10th Revision, code F84.0. We used the general US population as the reference to calculate proportionate mortality ratios (PMRs) and 95% confidence intervals (CIs)...
March 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28320174/etiological-agents-of-viral-meningitis-in-children-from-a-dengue-endemic-area-southeast-region-of-brazil
#11
Danilo B de Oliveira, Talitah M Candiani, Ana Paula M Franco-Luiz, Gabriel M F Almeida, Jônatas S Abrahão, Maria Rios, Roney S Coimbra, Erna G Kroon
Meningitis is a disease with a global distribution that constitutes a worldwide burden, with viruses as the primary etiologic agents. The range of viral meningitis severity depends mainly on age, immune status and etiological agent. The aim of this work was to investigate the suspected cases of viral meningitis using molecular techniques to confirm the viral infection. The diagnosed virus was correlated with clinical findings and cytochemical parameters in cerebrospinal liquid (CSF) of patients. CSF of 70 children with the presumptive diagnosis of viral meningitis was analyzed by real time PCR (qPCR)...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28320146/stroke-related-stigma-among-west-africans-patterns-and-predictors
#12
Fred Stephen Sarfo, Michelle Nichols, Suparna Qanungo, Abeba Teklehaimanot, Arti Singh, Nathaniel Mensah, Raelle Saulson, Mulugeta Gebregziabher, Uvere Ezinne, Mayowa Owolabi, Carolyn Jenkins, Bruce Ovbiagele
BACKGROUND: Disability-adjusted life-years lost after stroke in Low & Middle-Income Countries (LMICs) is almost seven times those lost in High-income countries. Although individuals living with chronic neurological and mental disorders are prone to stigma, there is a striking paucity of literature on stroke-related stigma particularly from LMICs. OBJECTIVE: To assess the prevalence, severity, determinants and psycho-social consequences of stigma among LMIC stroke survivors...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319691/trajectories-of-maternal-depressive-symptoms-in-the-early-childhood-period-and-family-wide-clustering-of-risk
#13
Sheri Madigan, Mark Wade, André Plamondon, Jennifer M Jenkins
BACKGROUND: Previous research on individual differences in the course of maternal depressive symptoms has yielded inconsistent findings, with significant variation in the number and pattern of trajectories identified. In addition, missing from the literature is a comprehensive examination of predictors and longitudinal consequences of particular depression trajectories. METHOD: Participants in this study included a community cohort of 501 women assessed for depression using the Center for Epidemiologic Depression Scale at infant age 2, 18, 36, and 54 months...
March 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28319688/attenuated-dhea-and-dhea-s-response-to-acute-psychosocial-stress-in-individuals-with-depressive-disorders
#14
Xiaoling Jiang, Wen Zhong, Haiyan An, Mingyu Fu, Yuanyuan Chen, Zhenggang Zhang, Zhongju Xiao
BACKGROUND: In recent years, a relationship between depression and basal dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) levels has frequently been suggested, but responses of these adrenal steroids to psychosocial stress have not been examined in individuals with depressive disorders. In this study, we examined salivary DHEA, DHEA-S, and cortisol/DHEA response to the Trier Social Stress Test (TSST) in individuals with depressive disorders and in healthy controls to discover whether the responses of DHEA and DHEA-S to acute psychosocial stress could be a more sensitive marker of HPA dysfunction in depressive disorders...
March 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28319530/oral-chemical-burns-reported-to-the-poisons-information-centre-in-erfurt-germany-from-1997-to-2014
#15
Juliane Nehrlich, Hans-Peter Klöcking, Helmut Hentschel, Amelie Lupp
Devastating oral burns often followed by lifelong complications can result from ingestion of caustic substances. However, although being one of the most challenging situations in clinical practice, literature data on the epidemiology of oral burns are still scarce. Retrospective analysis of all cases of oral burns after ingestion of corrosive substances reported to the Poisons Information Centre in Erfurt, Germany, from 1997 to 2014 was performed. In total, 482 calls because of oral burns were registered, with no change in the numbers of cases during the years...
March 13, 2017: Journal of Burn Care & Research: Official Publication of the American Burn Association
https://www.readbyqxmd.com/read/28319180/effect-of-outdoor-air-pollution-on-asthma-exacerbations-in-children-and-adults-systematic-review-and-multilevel-meta-analysis
#16
Pablo Orellano, Nancy Quaranta, Julieta Reynoso, Brenda Balbi, Julia Vasquez
BACKGROUND: Several observational studies have suggested that outdoor air pollution may induce or aggravate asthma. However, epidemiological results are inconclusive due to the presence of numerous moderators which influence this association. The goal of this study was to assess the relationship between outdoor air pollutants and moderate or severe asthma exacerbations in children and adults through a systematic review and multilevel meta-analysis. MATERIAL AND METHODS: We searched studies published in English on PubMed, Scopus, and Google Scholar between January 2000 and October 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28318900/epidemiological-and-mycological-characteristics-of-candidemia-in-iran-a-systematic-review-and-meta-analysis
#17
REVIEW
A Vaezi, H Fakhim, S Khodavaisy, A Alizadeh, M Nazeri, A Soleimani, T Boekhout, H Badali
To date, there has been no comprehensive review of the epidemiology, risk factors, species distribution, and outcomes of candidemia in Iran. This study aimed to perform a systematic review and meta-analysis of all reported candidemia cases in Iran until December 2015. The review process occurred in three steps, namely a literature search, data extraction and statistical analyses. After a comprehensive literature search, we identified 55 cases. The mean age of patients was 46.80±24.30 years (range 1-81 years)...
March 16, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28318817/clinical-and-mutational-characteristics-of-duchenne-muscular-dystrophy-patients-based-on-a-comprehensive-database-in-south-china
#18
Dan-Ni Wang, Zhi-Qiang Wang, Lei Yan, Jin He, Min-Ting Lin, Wan-Jin Chen, Ning Wang
The development of clinical trials for Duchenne muscular dystrophy (DMD) in China faces many challenges due to limited information about epidemiological data, natural history and clinical management. To provide these detailed data, we developed a comprehensive database based on registered DMD patients from South China and analysed their clinical and mutational characteristics. The database included DMD registrants confirmed by clinical presentation, family history, genetic detection, prognostic outcome, and/or muscle biopsy...
February 21, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28318516/-venous-thromboembolism-what-other-risk-factors-in-a-north-african-population-a-study-of-276%C3%A2-cases
#19
I Boukhris, M Abdallah, K Bouslema, S Hamzaoui, T Larbi, A Harmel, N Khalfallah, S Mrad
INTRODUCTION: Venous thromboembolism is a multicausal disease. Understanding interactions between risk factors is the key to advance knowledge about the etiology of venous thrombosis. These interactions are still unclear. In addition to traditional risk factors, there is data about many other risk factors, recorded with few populations based prospective epidemiologic studies or punctually reported. Interactions between these risk factors remain unclear. The aim of our work is to identify and analyze combinations of risk factors...
March 16, 2017: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/28318462/the-epidemiology-of-operation-stress-during-continuing-promise-2011-a-humanitarian-response-and-disaster-relief-mission-aboard-a-us-navy-hospital-ship
#20
William T Scouten, Melissa L Mehalick, Elizabeth Yoder, Andrea McCoy, Tracy Brannock, Mark S Riddle
Introduction Operational stress describes individual behavior in response to the occupational demands and tempo of a mission. The stress response of military personnel involved in combat and peace-keeping missions has been well-described. The spectrum of effect on medical professionals and support staff providing humanitarian assistance, however, is less well delineated. Research to date concentrates mainly on shore-based humanitarian missions. Problem The goal of the current study was to document the pattern of operational stress, describe factors responsible for it, and the extent to which these factors impact job performance in military and civilian participants of Continuing Promise 2011 (CP11), a ship-based humanitarian medical mission...
March 20, 2017: Prehospital and Disaster Medicine
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