keyword
https://read.qxmd.com/read/38455841/a-bayesian-machine-learning-approach-for-estimating-heterogeneous-survivor-causal-effects-applications-to-a-critical-care-trial
#1
JOURNAL ARTICLE
Xinyuan Chen, Michael O Harhay, Guangyu Tong, Fan Li
Assessing heterogeneity in the effects of treatments has become increasingly popular in the field of causal inference and carries important implications for clinical decision-making. While extensive literature exists for studying treatment effect heterogeneity when outcomes are fully observed, there has been limited development in tools for estimating heterogeneous causal effects when patient-centered outcomes are truncated by a terminal event, such as death. Due to mortality occurring during study follow-up, the outcomes of interest are unobservable, undefined, or not fully observed for many participants in which case principal stratification is an appealing framework to draw valid causal conclusions...
March 2024: Annals of Applied Statistics
https://read.qxmd.com/read/38454954/pulmonary-hypertension-in-an-adult-patient-with-congenital-central-hypoventilation-syndrome-a-case-report
#2
Yosuke Terui, Shoko Ohura, Tetsuji Nozaki, Takuya Yagi
BACKGROUND: Congenital central hypoventilation syndrome (CCHS) is a life-threatening disorder of autonomic respiratory control. Mutations in the paired-like homeobox 2B (PHOX2B) gene impair respiratory drive, causing hypercarbia and hypoxaemia. Most patients with CCHS are diagnosed in the neonatal period; however, a few are diagnosed in adulthood. CASE SUMMARY: We report a 32-year-old man with a history of unexplained cyanosis 14 days after birth. He presented to our hospital with breathlessness and abnormal electrocardiogram findings discovered in a health check-up...
March 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38452926/intraoperative-effects-of-an-alveolar-recruitment-manoeuvre-in-patients-undergoing-laparoscopic-colon-surgery
#3
JOURNAL ARTICLE
Rocío Mato-Búa, Ana Prado-Rodríguez, David López-López, Pablo Rama-Maceiras, Nieves Molins-Gauna, Felisa Álvarez-Refojo
INTRODUCTION: Pulmonary atelectasis is common in patients undergoing laparoscopic abdominal surgery under general anaesthesia, which increases the risk of perioperative respiratory complications. Alveolar recruitment manoeuvres (ARM) are used to open up the lung parenchyma with atelectasis, although the duration of their benefit has not been clearly established. The aim of this study was to determine the effectiveness of an ARM in laparoscopic colon surgery, the duration of response over time, and its haemodynamic impact...
March 5, 2024: Revista española de anestesiología y reanimación
https://read.qxmd.com/read/38380202/hepatopulmonary-syndrome-diagnosis-in-the-icu-the-relevance-of-bedside-contrast-saline-echocardiography
#4
Rita Morais Passos, Francisca Cardoso, Francisco Teixeira da Silva, Rogério Corga da Silva, José Caldeiro
Hepatopulmonary syndrome (HPS) is an underdiagnosed complication of chronic liver disease (CLD) characterised by the presence of hypoxaemia due to intrapulmonary vascular dilatations. We present two cases of HPS diagnosed during their stay in the ICU. Both patients had a medical history of alcoholic CLD with portal hypertension (PH). The first patient was transferred to the ICU for acute hypoxic respiratory failure (AHRF) due to decompensated cirrhosis with large-volume hydrothorax and diagnosis of acute-on-chronic liver failure (ACLF) grade 2...
January 2024: Curēus
https://read.qxmd.com/read/38268196/effects-of-butorphanol-on-respiration-in-white-rhinoceros-ceratotherium-simum-immobilized-with-etorphine-azaperone
#5
JOURNAL ARTICLE
Peter Buss, Michele Miller, Andrea Fuller, Anna Haw, Emily Thulson, Francisco Olea-Popelka, Leith Meyer
This article reports on respiratory function in white rhinoceros (Ceratotherium simum) immobilized with etorphine-azaperone and the changes induced by butorphanol administration as part of a multifaceted crossover study that also investigated the effects of etorphine or etorphine-butorphanol treatments. Six male white rhinoceros underwent two immobilizations by using 1) etorphine-azaperone and 2) etorphine-azaperone-butorphanol. Starting 10 min after recumbency, arterial blood gases, limb muscle tremors, expired minute ventilation, and fR were evaluated at 5-min intervals for 25 min...
January 25, 2024: Journal of Wildlife Diseases
https://read.qxmd.com/read/38219385/l-cysteine-ethylester-reverses-the-adverse-effects-of-morphine-on-breathing-and-arterial-blood-gas-chemistry-while-minimally-affecting-antinociception-in-unanesthetized-rats
#6
JOURNAL ARTICLE
Santhosh M Baby, Walter J May, Alex P Young, Christopher G Wilson, Paulina M Getsy, Gregory A Coffee, Tristan H J Lewis, Yee-Hee Hsieh, James N Bates, Stephen J Lewis
L-cysteine ethylester (L-CYSee) is a membrane-permeable analogue of L-cysteine with a variety of pharmacological effects. The purpose of this study was to determine the effects of L-CYSee on morphine-induced changes in ventilation, arterial-blood gas (ABG) chemistry, Alveolar-arterial (A-a) gradient (i.e., a measure of the index of alveolar gas-exchange), antinociception and sedation in male Sprague Dawley rats. An injection of morphine (10 mg/kg, IV) produced adverse effects on breathing, including sustained decreases in minute ventilation...
January 13, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38154981/-budd-chiari-syndrome-with-hepatopulmonary-syndrome-a-case-report-and-literature-review
#7
REVIEW
F Y Tian, X Dong, X H Hou, R Y Yuan, Y W Pan, D Zhang
Objective: To summarize the clinical features and prognosis of Budd-Chiari syndrome with hepatopulmonary syndrome (HPS) in children. Methods: The clinical data of a child who had Budd-Chiari syndrome with HPS treated at the Department of Pediatrics of the First Affiliated Hospital of Zhengzhou University in December 2016 was analyzed retrospectively. Taking "Budd-Chiari syndrome" and "hepatopulmonary syndrome" in Chinese or English as the keywords, literature was searched at CNKI, Wanfang, China Biomedical Literature Database and PubMed up to July 2023...
January 2, 2024: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/38093907/asymmetric-and-symmetric-dimethylarginine-in-high-altitude-pulmonary-hypertension-haph-and-high-altitude-pulmonary-edema-hape
#8
JOURNAL ARTICLE
Juliane Hannemann, Julius Freytag, Lisa Maria Schiefer, Franziska Macholz, Mahdi Sareban, Lena Schmidt-Hutten, Heike Stang, Edzard Schwedhelm, Erik R Swenson, Rainer Böger, Marc Moritz Berger
Introduction: High altitude exposure may lead to high altitude pulmonary hypertension (HAPH) and high altitude pulmonary edema (HAPE). The pathophysiologic processes of both entities have been linked to decreased nitric oxide (NO) availability. Methods: We studied the effect of acute high altitude exposure on the plasma concentrations of asymmetric (ADMA) and symmetric dimethylarginine (SDMA), L-arginine, L-ornithine, and L-citrulline in two independent studies. We further investigated whether these biomarkers involved in NO metabolism were related to HAPH and HAPE, respectively...
2023: Frontiers in Physiology
https://read.qxmd.com/read/38003068/study-of-transcriptomic-analysis-of-yak-bos-grunniens-and-cattle-bos-taurus-pulmonary-artery-smooth-muscle-cells-under-oxygen-concentration-gradients-and-differences-in-their-lung-histology-and-expression-of-pyruvate-dehydrogenase-kinase-1-related-factors
#9
JOURNAL ARTICLE
Yiyang Zhang, Manlin Zhou, Yuxin Liang, Rui Li, Lan Zhang, Shuwu Chen, Kun Yang, Haie Ding, Xiao Tan, Qian Zhang, Zilin Qiao
The aim of this study was to investigate the molecular mechanisms by which hypoxia affects the biological behavior of yak PASMCs, the changes in the histological structure of yak and cattle lungs, and the relationships and regulatory roles that exist regarding the differences in the distribution and expression of PDK1 and its hypoxia-associated factors screened for their role in the adaptation of yak lungs to the plateau hypoxic environment. The results showed that, at the level of transcriptome sequencing, the molecular regulatory mechanisms of the HIF-1 signaling pathway, glucose metabolism pathway, and related factors (HK2/PGK1/ENO1/ENO3/ALDOC/ALDOA) may be closely related to the adaptation of yaks to the hypoxic environment of the plateau; at the tissue level, the presence of filled alveoli and semi-filled alveoli, thicker alveolar septa and basement membranes, a large number of erythrocytes, capillary distribution, and collagen fibers accounted for all levels of fine bronchioles in the lungs of yaks as compared to cattle...
November 8, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37993127/nebulised-granulocyte-macrophage-colony-stimulating-factor-gm-csf-in-autoimmune-pulmonary-alveolar-proteinosis-a-systematic-review-and-meta-analysis
#10
REVIEW
Maitri Munsif, Duncan Sweeney, Tracy L Leong, Rob G Stirling
BACKGROUND: Autoimmune pulmonary alveolar proteinosis (aPAP) results from impaired macrophage-mediated clearance of alveolar surfactant lipoproteins. Whole lung lavage has been the first-line treatment but recent reports suggest the efficacy of granulocyte-macrophage colony-stimulating factor (GM-CSF). We aimed to review the efficacy and safety of nebulised GM-CSF in aPAP. METHODS: We conducted a systematic review and meta-analysis searching Embase, CINAHL, MEDLINE and Cochrane Collaborative databases (1946-1 April 2022)...
December 31, 2023: European Respiratory Review: An Official Journal of the European Respiratory Society
https://read.qxmd.com/read/37924360/neurogenic-pulmonary-edema-and-takotsubo-cardiomyopathy-in-aneurysmal-subarachnoid-hemorrhage
#11
JOURNAL ARTICLE
Eui-Hyun Hwang, Ja Ho Koo, Yeon Hu Lee, Ji Hye Song, Yong Cheol Lim
PURPOSE: Neurogenic pulmonary edema (NPE) combined with Takotsubo cardiomyopathy (TCM) is a rare condition associated with aneurysmal subarachnoid hemorrhage (aSAH). Although several mechanisms have been proposed, the pathophysiology and management strategies are not yet fully established. We aimed to determine the radiological and clinical outcomes of patients with NPE and with TCM after aSAH to propose management strategies. METHODS: We analyzed the data of 564 patients with aSAH recorded at a single medical center from February 2015 to July 2022...
November 4, 2023: Acta Neurochirurgica
https://read.qxmd.com/read/37885800/effects-of-sub-lethal-doses-of-fentanyl-on-vital-physiologic-functions-and-withdrawal-like-behaviors-in-adult-goats
#12
JOURNAL ARTICLE
Suzanne E Neumueller, Nicole Buiter, Grace Hilbert, Kirstyn Grams, Reiauna Taylor, John Desalvo, Grace L Hodges, Madeline M Hodges, Lawrence G Pan, Stephen J Lewis, Hubert V Forster, Matthew R Hodges
Synthetic opioids like fentanyl have improved the standard of care for many patients in the clinical setting, but their abuse leads to tens of thousands of overdose deaths annually. The current opioid epidemic underscores a critical need for insights into the physiological effects of fentanyl on vital functions. High doses of opioids in small mammals cause opioid-induced respiratory depression (OIRD) leading to hypoventilation, hypoxemia, and hypercapnia. In addition, opioids can also increase the alveolar to arterial oxygen (A-a) gradient and airway dysfunction...
2023: Frontiers in Physiology
https://read.qxmd.com/read/37654953/bilateral-arteriovenous-shunting-through-pial-and-perforating-vessels-with-multiple-strokes-in-a-patient-with-hepatopulmonary-syndrome
#13
Baha Aljeradat, Manisha Koneru, Renato Oliveira, Hamza Shaikh
Hepatopulmonary syndrome (HPS) is a condition characterized by chronic liver disease, intrapulmonary arteriovenous shunting, and increased alveolar-arterial oxygen gradient. This case report presents a 54-year-old male patient with a history of stroke, liver cirrhosis, portal vein thrombosis, hypertension, diabetes, and bladder cancer, who presented with worsening headaches and confusion over the course of five years. Digital subtraction angiogram (DSA) revealed multiple bilateral arteriovenous shunts, suggesting a shunting mechanism similar to that observed in HPS...
July 2023: Curēus
https://read.qxmd.com/read/37575612/effects-of-three-immobilizing-drug-combinations-on-ventilation-gas-exchange-and-metabolism-in-free-living-african-lions-panthera-leo
#14
JOURNAL ARTICLE
Ashleigh Claire Donaldson, Peter Erik Buss, Andrea Fuller, Leith Carl Rodney Meyer
Free-living lions (12 per group) were immobilized with tiletamine-zolazepam-medetomidine (TZM), ketamine-medetomidine (KM), or ketamine-butorphanol-medetomidine (KBM). During immobilization, respiratory, blood gas and acid-base variables were monitored for 30 minutes. Respiratory rates were within expected ranges and remained constant throughout the immobilizations. Ventilation increased in lions over the immobilization period from 27.2 ± 9.5 to 35.1 ± 25.4 L/min (TZM), 26...
2023: Conservation Physiology
https://read.qxmd.com/read/37408073/alteration-of-circulating-redox-balance-in-coronavirus-disease-19-induced-acute-respiratory-distress-syndrome
#15
JOURNAL ARTICLE
Francesco Bellanti, Sławomir Kasperczyk, Aleksandra Kasperczyk, Michał Dobrakowski, Gabriella Pacilli, Giuseppina Vurchio, Alessandro Maddalena, Stefano Quiete, Aurelio Lo Buglio, Cristiano Capurso, Gaetano Serviddio, Gianluigi Vendemiale
BACKGROUND: Mechanisms underpinning ARDS induced by COVID-19 are mostly immune-mediated, but need to be completely clarified. This study aimed to investigate redox balance in COVID-19 patients with ARDS, trying to recognize possible differences from typical ARDS related to the pathophysiology of severe disease. METHODS: Patients affected by ARDS and positive for the SARS-CoV-2 virus (N = 40, COVID-19) were compared to ARDS patients negative to the molecular test (N = 42, No COVID-19)...
July 5, 2023: Journal of Intensive Care
https://read.qxmd.com/read/37306270/comparison-of%C3%A2-positive-pressure-extubation-with-traditional-extubation-in-critically-ill-patients-a%C3%A2-randomised-control-study
#16
RANDOMIZED CONTROLLED TRIAL
Ajeetviswanath Thanjavur Prabhakaran, Darlong Vanalal, Kapil Soni, Dalim Baidya, Richa Aggarwal, Harsha Binu, Shivanand Gamanagatti, Maya Dehran, Anjan Trikha
BACKGROUND: Two extubation methods are commonly used in the intensive care unit (ICU): the traditional method with endotracheal suctioning and the positive- pressure method without suctioning. Better physiological outcomes were found in lab studies using the latter, as the air passing between the endotracheal tube and the larynx pushes out the collected subglottic secretions, which can be suctioned. METHODS: 70 mechanically ventilated patients in a tertiary ICU were randomised into 2 groups of 35 patients each...
2023: Anaesthesiology Intensive Therapy
https://read.qxmd.com/read/37297869/barotrauma-during-noninvasive-respiratory-support-in-covid-19-pneumonia-outside-icu-the-ancillary-covimix-2-study
#17
JOURNAL ARTICLE
Luigi Vetrugno, Cristian Deana, Nadia Castaldo, Alberto Fantin, Alessandro Belletti, Emanuela Sozio, Maria De Martino, Miriam Isola, Diego Palumbo, Federico Longhini, Gianmaria Cammarota, Savino Spadaro, Salvatore Maurizio Maggiore, Flavio Bassi, Carlo Tascini, Vincenzo Patruno, Covimix-Study Group
BACKGROUND: Noninvasive respiratory support (NIRS) has been extensively used during the COVID-19 surge for patients with acute respiratory failure. However, little data are available about barotrauma during NIRS in patients treated outside the intensive care unit (ICU) setting. METHODS: COVIMIX-2 was an ancillary analysis of the previous COVIMIX study, a large multicenter observational work investigating the frequencies of barotrauma (i.e., pneumothorax and pneumomediastinum) in adult patients with COVID-19 interstitial pneumonia...
May 25, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37137756/a-systematic-review-and-meta-analysis-of-clinical-respiratory-and-biochemical-risk-factors-for-acute-exacerbation-of-idiopathic-pulmonary-fibrosis
#18
REVIEW
Angelo Zinellu, Alessandro G Fois, Pietro Pirina, Ciriaco Carru, Arduino A Mangoni
BACKGROUND: A better capacity to identify patients with idiopathic pulmonary fibrosis (IPF) at risk of acute exacerbation (AEIPF) might improve outcomes and reduce healthcare costs. AIMS: We critically appraised the available evidence of the differences in clinical, respiratory, and biochemical parameters between AEIPF and IPF patients with stable disease (SIPF) by conducting a systematic review and meta-analysis. METHODS: PubMed, Web of Science and Scopus were reviewed up until August 1, 2022, for studies reporting differences in clinical, respiratory, and biochemical parameters (including investigational biomarkers) between AEIPF and SIPF patients...
May 1, 2023: Archives of Medical Research
https://read.qxmd.com/read/37081515/association-between-one-session-bilateral-whole-lung-lavage-and-periprocedural-complications-in-patients-with-pulmonary-alveolar-proteinosis-a-retrospective-cohort-study
#19
JOURNAL ARTICLE
Xiaohan Xu, Huanrong Qiu, Fei Chen, Yuelun Zhang, Xinlun Tian, Yongjian Liu, Ping Wang, Bo Zhu, Yuguang Huang
BACKGROUND: Whole lung lavage (WLL) has been recognized as the most effective therapy of severe pulmonary alveolar proteinosis (PAP). Most centers perform the lavage of each lung in two sessions under general anesthesia at an interval of several days to weeks. Compared with two-session WLL, one-session bilateral sequential WLL only requires general anesthesia once. However, the safety of one-session WLL in PAP patients has not been assessed by large cohort studies. In this study, we aimed to investigate the association between the mode of WLL procedure (one-session or two-session) and the risk of periprocedural complications in PAP patients...
April 20, 2023: Orphanet Journal of Rare Diseases
https://read.qxmd.com/read/37076114/alveolar-arterial-oxygen-gradient-nonlinearly-impacts-the-28-day-mortality-of-patients-with-sepsis-secondary-data-mining-based-on-the-mimic-iv-database
#20
MULTICENTER STUDY
Ying Wang, Yan He, Lu Chen, Ying Liu, Jia Yuan, Hongying Bi, Qimin Chen, Xianjun Chen, Feng Shen
OBJECTIVE: Lung is often implicated in sepsis, resulting in acute respiratory distress syndrome (ARDS). The alveolar-arterial oxygen gradient [D(A-a)O2 ] reflects lung diffusing capacity, which is usually compromised in ARDS. But whether D(A-a)O2 impacts the prognosis of patients with sepsis remains to be explored. Our study aims to investigate the association between D(A-a)O2 and 28-day mortality in patients with sepsis using a large sample, multicenter Medical Information Mart for Intensive Care (MIMIC)-IV database...
May 2023: Clinical Respiratory Journal
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