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https://www.readbyqxmd.com/read/28222402/impact-of-anchor-type-on-porcine-lumbar-biomechanics-finite-element-modelling-and-in-vitro-validation
#1
Martin Brummund, Vladimir Brailovski, Yvan Petit, Yann Facchinello, Jean-Marc Mac-Thiong
BACKGROUND: Rigid posterior implants used for spinal stabilization can be anchored to the vertebrae using pedicle screws or screws combined with transverse process hooks. In the present study, a finite element model of a porcine lumbar spine instrumented with screws and hooks is presented and validated. METHODS: The porcine lumbar spine model was validated using in-vitro measurements on six porcine specimens. Validation metrics included intervertebral rotations (L1 to L6) and nucleus pressure in the topmost cranial instrumented disc...
February 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28222388/microbial-profile-of-dental-plaque-associated-to-white-spot-lesions-in-orthodontic-patients-immediately-after-the-bracket-removal
#2
Moniek W Beerens, Jacob M Ten Cate, Monique H van der Veen
OBJECTIVE: Denaturing Gradient Gel Electrophoresis (DGGE) is suggested to predict caries risk in young children. Such a tool would be valuable in orthodontic patients undergoing treatment with fixed appliances. In this cross-sectional study the applicability of DGGE and conventional microbiology for caries risk assessment in orthodontic patients were assessed. DESIGN: Dental plaque was obtained from orthodontic patients immediately prior to bracket removal. Presence of white spot lesions (WSL) was assessed immediately post debracketing...
February 9, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28222386/heterogeneous-fractionation-profiles-of-meta-analytic-coactivation-networks
#3
Angela R Laird, Michael C Riedel, Mershack Okoe, Radu Jianu, Kimberly L Ray, Simon B Eickhoff, Stephen M Smith, Peter T Fox, Matthew T Sutherland
Computational cognitive neuroimaging approaches can be leveraged to characterize the hierarchical organization of distributed, functionally specialized networks in the human brain. To this end, we performed large-scale mining across the BrainMap database of coordinate-based activation locations from over 10,000 task-based experiments. Meta-analytic coactivation networks were identified by jointly applying independent component analysis (ICA) and meta-analytic connectivity modeling (MACM) across a wide range of model orders (i...
February 18, 2017: NeuroImage
https://www.readbyqxmd.com/read/28222293/inhibitory-control-mapping-medial-frontal-cortex
#4
Nandakumar S Narayanan, Mark Laubach
Functional anatomy in frontal cortex has been elusive and controversial. A new study combines neuronal ensemble recordings and optogenetics to map a functional gradient in rodent prefrontal cortex that supports inhibitory control.
February 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28222255/stemness-signature-of-equine-marrow-derived-mesenchymal-stem-cells
#5
Morteza Zahedi, Abbas Parham, Hesam Dehghani, Hossein Kazemi Mehrjerdi
Background: Application of competent cells such as mesenchymal stem cells (MSCs) for treatment of musculoskeletal disorders in equine athletes is increasingly needed. Moreover, similarities of horse and human in size, load and types of joint injuries, make horse as a good model for MSCs therapy studies. This study was designed to isolate and characterize stemness signature of equine bone marrow-derived mesenchymal stem cells (BM-MSCs). Methods: BM of three mares was aspirated and the mononuclear cells (MNCs) were isolated using density gradient...
February 28, 2017: International Journal of Stem Cells
https://www.readbyqxmd.com/read/28222234/transcriptome-analysis-of-the-brassica-napus-leptosphaeria-maculans-pathosystem-identifies-receptor-signalling-and-structural-genes-underlying-plant-resistance
#6
Michael G Becker, Xuehua Zhang, Philip L Walker, Joey C Wan, Jenna L Millar, Deirdre Khan, Matthew J Granger, Jacob D Cavers, Ainsley C Chan, Dilantha W G Fernando, Mark F Belmonte
The hemibiotrophic fungal pathogen Leptosphaeria maculans is the causal agent of blackleg disease in Brassica napus (canola, oilseed rape) and causes significant yield loss worldwide. While genetic resistance has been used to mitigate the disease using traditional breeding strategies, there is little knowledge about the genes contributing to blackleg resistance. RNA sequencing and a streamlined bioinformatics pipeline identified unique genes and plant defense pathways specific to plant resistance in the B. napus-L...
February 21, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28222140/in-situ-single-cell-detection-via-microfluidic-magnetic-bead-assay
#7
Fan Liu, Pawan Kc, Ge Zhang, Jiang Zhe
We present a single cell detection device based on magnetic bead assay and micro Coulter counters. This device consists of two successive micro Coulter counters, coupled with a high gradient magnetic field generated by an external magnet. The device can identify single cells in terms of the transit time difference of the cell through the two micro Coulter counters. Target cells are conjugated with magnetic beads via specific antibody and antigen binding. A target cell traveling through the two Coulter counters interacts with the magnetic field, and have a longer transit time at the 1st counter than that at the 2nd counter...
2017: PloS One
https://www.readbyqxmd.com/read/28222006/adaptive-discrete-hypergraph-matching
#8
Junchi Yan, Changsheng Li, Yin Li, Guitao Cao
This paper addresses the problem of hypergraph matching using higher-order affinity information. We propose a solver that iteratively updates the solution in the discrete domain by linear assignment approximation. The proposed method is guaranteed to converge to a stationary discrete solution and avoids the annealing procedure and ad-hoc post binarization step that are required in several previous methods. Specifically, we start with a simple iterative discrete gradient assignment solver. This solver can be trapped in an m-circle sequence under moderate conditions, where m is the order of the graph matching problem...
February 17, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28221241/hyperpolarized-helium-3-diffusion-weighted-magnetic-resonance-imaging-detects-abnormalities-of-lung-structure-in-children-with-bronchopulmonary-dysplasia
#9
Lucia Flors, John P Mugler, Alix Paget-Brown, Deborah K Froh, Eduard E de Lange, James T Patrie, Talissa A Altes
PURPOSE: The aim of the study was to determine whether hyperpolarized He diffusion-weighted magnetic resonance imaging detects abnormalities in the lungs in children with bronchopulmonary dysplasia (BPD) as compared with age-matched normal children. MATERIALS AND METHODS: All experiments were compliant with Health Insurance Portability and Accountability Act (HIPAA) and performed with Food and Drug Administration approval under an IND application. The protocol was approved by our Institutional Review Board, and written informed consent was obtained...
February 17, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28221162/antiferromagnetic-spin-cantings-as-a-driving-force-of-ferroelectricity-in-multiferroic-cu-sub-2-sub-oseo-sub-3-sub
#10
Viacheslav Chizhikov, V Dmitrienko
Ferroelectric properties of cubic chiral magnet Cu<sub>2</sub>OSeO<sub>3</sub> can emerge due to the spin noncollinearity induced by antiferromagnetic cantings. The cantings are the result of the Dzyaloshinskii-Moriya interaction and in many ways similar to the ferromagnetic cantings in weak ferromagnets. An expression for the local electric polarization is derived, including terms with gradients of magnetization <b>M</b>(<b>r</b>). When averaged over the crystal the electric polarization has a non-vanishing part associated with the anisotropy of the crystal point group 23...
February 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28221081/threat-intensity-widens-fear-generalization-gradients
#11
Joseph E Dunsmoor, Marijn C W Kroes, Stephen H Braren, Elizabeth A Phelps
Research in nonhuman animals reveals threat-sensitive generalization of defensive behavior that favors widespread generalization when threat intensity is high and limited generalization (i.e., specificity) when threat intensity is low. Here, we used Pavlovian fear conditioning to systematically investigate whether threat intensity widens behavioral generalization gradients to stimuli that decreasingly resemble a learned threat cue. Using a between-subjects design, volunteers underwent fear conditioning with a tone paired with either a high-intensity or low-intensity aversive stimulus prior to a test of fear generalization to novel tones...
February 20, 2017: Behavioral Neuroscience
https://www.readbyqxmd.com/read/28221030/control-of-grafting-density-and-distribution-in-graft-polymers-by-living-ring-opening-metathesis-copolymerization
#12
Tzu-Pin Lin, Alice B Chang, Hsiang-Yun Chen, Allegra L Liberman-Martin, Christopher M Bates, Matthew J Voegtle, Christina A Bauer, Robert H Grubbs
Control over polymer sequence and architecture is crucial to both understanding structure-property relationships and designing functional materials. In pursuit of these goals, we developed a new synthetic approach that enables facile manipulation of the density and distribution of grafts in polymers via living ring-opening metathesis polymerization (ROMP). Discrete endo,exo-norbornenyl dialkylesters (dimethyl DME, diethyl DEE, di-n-butyl DBE) were strategically designed to copolymerize with a norbornene-functionalized polystyrene (PS), polylactide (PLA), or polydimethylsiloxane (PDMS) macromonomer mediated by the 3rd generation catalyst (G3)...
February 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28220944/magnetic-resonance-examination-of-patients-with-implanted-pacemakers-an-evaluation-of-magnetic-field-gradients-slew-rate
#13
Diego Trevisan, Gloria Miori, Armando Correale, Davide Libralon
Performing safe magnetic resonance imaging of patients with "MR conditional" pacemakers needs to meet some specific restrictions. One of these is related to the slew rate (SR) parameter, defined as the speed of magnetic field gradients rising up to their required strengths. Unfortunately, SR values cannot be easily checked at the tomograph console. The present work provides an accurate evaluation of the maximum SR for a set of widely used clinical MR sequences. The experimental approach is based on indirect measurement of time-varying spatial magnetic field gradients...
February 21, 2017: Bioelectromagnetics
https://www.readbyqxmd.com/read/28220835/effects-of-abiotic-factors-on-ecosystem-health-of-taihu-lake-china-based-on-eco-exergy-theory
#14
Ce Wang, Jun Bi, Brian D Fath
A lake ecosystem is continuously exposed to environmental stressors with non-linear interrelationships between abiotic factors and aquatic organisms. Ecosystem health depicts the capacity of system to respond to external perturbations and still maintain structure and function. In this study, we explored the effects of abiotic factors on ecosystem health of Taihu Lake in 2013, China from a system-level perspective. Spatiotemporal heterogeneities of eco-exergy and specific eco-exergy served as thermodynamic indicators to represent ecosystem health in the lake...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220617/wave-caipi-for-highly-accelerated-mp-rage-imaging
#15
Daniel Polak, Kawin Setsompop, Stephen F Cauley, Borjan A Gagoski, Himanshu Bhat, Florian Maier, Peter Bachert, Lawrence L Wald, Berkin Bilgic
PURPOSE: To introduce a highly accelerated T1-weighted magnetization-prepared rapid gradient echo (MP-RAGE) acquisition that uses wave-controlled aliasing in parallel imaging (wave-CAIPI) encoding to retain high image quality. METHODS: Significant acceleration of the MP-RAGE sequence is demonstrated using the wave-CAIPI technique. Here, sinusoidal waveforms are used to spread aliasing in all three directions to improve the g-factor. Combined with a rapid (2 s) coil sensitivity acquisition and data-driven trajectory calibration, we propose an online integrated acquisition-reconstruction pipeline for highly efficient MP-RAGE imaging...
February 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28220443/contaminated-area-instability-along-%C3%A3-ngerman%C3%A3-lven-river-northern-sweden
#16
A Ströberg, K Ebert, J Jarsjö, A Frampton
Industrially utilized river basins are frequently exposed to contaminants originating from polluting activities. However, the physical instability and probability of mass movement mobilization of contaminated soil into rivers have only received little attention. In this study, we present a GIS-based method to produce a regional overview of where and how contaminated areas are potentially exposed to slope instability. A landslide susceptibility-index was used to study the degree and distribution of overlap between contaminated sites and unstable ground...
March 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28220365/binding-of-11-c-pittsburgh-compound-b-correlated-with-white-matter-injury-in-hypertensive-small-vessel-disease
#17
Tetsuya Hashimoto, Chiaki Yokota, Kazuhiro Koshino, Takashi Temma, Makoto Yamazaki, Satoshi Iguchi, Ryo Shimomura, Toshiyuki Uehara, Naoko Funatsu, Tenyu Hino, Kazuo Minematsu, Hidehiro Iida, Kazunori Toyoda
OBJECTIVE: (11)C-Pittsburgh compound-B ((11)C-PIB) positron emission tomography (PET) is used to visualize and quantify amyloid deposition in the brain cortex in pathological conditions such as Alzheimer's disease (AD). Intense (11)C-PIB retention is also observed in the white matter (WM) of both healthy individuals and AD patients. However, the clinical implications of this retention in brain WM have not been clarified. We investigated the relationship between the extent of white matter lesions (WMLs) and the binding potential of (11)C-PIB (BPND) in the WM in patients with hypertensive small vessel disease...
February 20, 2017: Annals of Nuclear Medicine
https://www.readbyqxmd.com/read/28220275/open-source-vendor-independent-automated-multi-beat-tissue-doppler-echocardiography-analysis
#18
Niti M Dhutia, Massoud Zolgharni, Michael Mielewczik, Madalina Negoita, Stefania Sacchi, Karikaran Manoharan, Darrel P Francis, Graham D Cole
Current guidelines for measuring cardiac function by tissue Doppler recommend using multiple beats, but this has a time cost for human operators. We present an open-source, vendor-independent, drag-and-drop software capable of automating the measurement process. A database of ~8000 tissue Doppler beats (48 patients) from the septal and lateral annuli were analyzed by three expert echocardiographers. We developed an intensity- and gradient-based automated algorithm to measure tissue Doppler velocities. We tested its performance against manual measurements from the expert human operators...
February 20, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28219924/time-trends-and-educational-inequalities-in-out-of-hospital-coronary-deaths-in-norway-1995-2009-a-cardiovascular-disease-in-norway-cvdnor-project
#19
Enxhela Sulo, Ottar Nygård, Stein Emil Vollset, Jannicke Igland, Marta Ebbing, Truls Østbye, Torben Jørgensen, Gerhard Sulo, Grethe S Tell
BACKGROUND: Recent time trends and educational gradients characterizing out-of-hospital coronary deaths (OHCD) are poorly described. METHODS AND RESULTS: We identified all deaths from coronary heart disease occurring outside the hospital in Norway during 1995 to 2009. Time trends were explored using Poisson regression analysis with year as the independent, continuous variable. Information on the highest achieved education was obtained from The National Education Database and classified as primary (up to 10 years of compulsory education), secondary (high school or vocational school), or tertiary (college/university)...
February 20, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28219796/simultaneous-quantitation-of-abiraterone-enzalutamide-n-desmethyl-enzalutamide-and-bicalutamide-in-human-plasma-by-lc-ms-ms
#20
Kyu-Pyo Kim, Robert A Parise, Julianne L Holleran, Lionel D Lewis, Leonard Appleman, Nielka van Erp, Michael J Morris, Jan H Beumer
Inhibiting the androgen receptor (AR) pathway is an important clinical strategy in metastatic prostate cancer. Novel agents including abiraterone acetate and enzalutamide have been shown to prolong life in men with metastatic, castration-resistant prostate cancer (mCRPC). To evaluate the pharmacokinetics of AR-targeted agents, we developed and validated an LC-MS/MS assay for the quantitation of enzalutamide, N-desmethyl enzalutamide, abiraterone and bicalutamide in 0.05mL human plasma. After protein precipitation, chromatographic separation was achieved with a Phenomenex Synergi Polar-RP column and a linear gradient of 0...
February 13, 2017: Journal of Pharmaceutical and Biomedical Analysis
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