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https://www.readbyqxmd.com/read/28930815/variability-in-usual-care-mechanical-ventilation-for-pediatric-acute-respiratory-distress-syndrome-time-for-a-decision-support-protocol
#1
Christopher J L Newth, Katherine A Sward, Robinder G Khemani, Kent Page, Kathleen L Meert, Joseph A Carcillo, Thomas P Shanley, Frank W Moler, Murray M Pollack, Heidi J Dalton, David L Wessel, John T Berger, Robert A Berg, Rick E Harrison, Richard Holubkov, Allan Doctor, J Michael Dean, Tammara L Jenkins, Carol E Nicholson
OBJECTIVES: Although pediatric intensivists philosophically embrace lung protective ventilation for acute lung injury and acute respiratory distress syndrome, we hypothesized that ventilator management varies. We assessed ventilator management by evaluating changes to ventilator settings in response to blood gases, pulse oximetry, or end-tidal CO2. We also assessed the potential impact that a pediatric mechanical ventilation protocol adapted from National Heart Lung and Blood Institute acute respiratory distress syndrome network protocols could have on reducing variability by comparing actual changes in ventilator settings to those recommended by the protocol...
September 19, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28926324/treatment-of-anorexia-nervosa-the-importance-of-disease-progression-in-the-prognosis
#2
Rodrigo Andrade, Manuel Gonçalves-Pinho, António Roma-Torres, Isabel Brandão
INTRODUCTION: Anorexia nervosa is a severe, usually chronic, life-threatening disease of complex etiology characterized by food restriction, overestimation of the importance of body weight and image, intense fear of weight gain and distortion of body image. Anorexia nervosa is associated with high rates of mortality, suicide and decreased quality of life. Our aim is to present an anorexia nervosa treatment program offered in a major university hospital in Portugal, and to determine the impact of illness duration before admission on the outcome...
August 31, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28924264/neurocognitive-and-behavioral-functioning-in-adolescents-with-sleep-disordered-breathing-a-population-based-dual-energy-x-ray-absorptiometry-study
#3
S S Frye, J Fernandez-Mendoza, S L Calhoun, J Gaines, M D Sawyer, F He, D Liao, A N Vgontzas, E O Bixler
BACKGROUND/OBJECTIVES: Sleep disordered breathing (SDB) has been associated with neurocognitive and behavioral problems in young children; however, this association is less studied in adolescents. Evidence suggests that obesity plays a key role in the development of SDB, although its relative association with neurobehavioral functioning remains unclear. We examined whether SDB and obesity are associated with neurocognitive and behavior problems in adolescents. SUBJECTS/METHODS: 421 adolescents (17...
September 19, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28923661/the-influence-of-the-aquatic-environment-on-the-center-of-pressure-impulses-and-upper-and-lower-trunk-accelerations-during-gait-initiation
#4
Andresa R Marinho-Buzelli, Kei Masani, Hossein Rouhani, Ana M Barela, Gustavo T B Fernandes, Mary C Verrier, Milos R Popovic
Gait initiation is defined as the transition from stationary standing to steady-state walking. Despite the frequent use of therapy pools for training walking in early stages of rehabilitation, none have been reported on the effects of immersion on gait initiation. We aimed to analyze the center of pressure (COP) trajectories, the vertical and anteroposterior impulses and upper and lower trunk accelerations during anticipatory (APA) and execution phases of gait initiation. In the COP trajectory, the execution (EXE) phase was further subdivided in two phases: predominantly mediolateral (EXE1), and predominantly anteroposterior (EXE2)...
September 8, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28919842/international-society-of-sports-nutrition-position-stand-nutrient-timing
#5
REVIEW
Chad M Kerksick, Shawn Arent, Brad J Schoenfeld, Jeffrey R Stout, Bill Campbell, Colin D Wilborn, Lem Taylor, Doug Kalman, Abbie E Smith-Ryan, Richard B Kreider, Darryn Willoughby, Paul J Arciero, Trisha A VanDusseldorp, Michael J Ormsbee, Robert Wildman, Mike Greenwood, Tim N Ziegenfuss, Alan A Aragon, Jose Antonio
The International Society of Sports Nutrition (ISSN) provides an objective and critical review regarding the timing of macronutrients in reference to healthy, exercising adults and in particular highly trained individuals on exercise performance and body composition. The following points summarize the position of the ISSN:Nutrient timing incorporates the use of methodical planning and eating of whole foods, fortified foods and dietary supplements. The timing of energy intake and the ratio of certain ingested macronutrients may enhance recovery and tissue repair, augment muscle protein synthesis (MPS), and improve mood states following high-volume or intense exercise...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28919065/metabolically-healthy-obesity-the-low-hanging-fruit-in-obesity-treatment
#6
REVIEW
Norbert Stefan, Hans-Ulrich Häring, Matthias B Schulze
Obesity increases the risk of several other chronic diseases and, because of its epidemic proportions, has become a major public health problem worldwide. Alarmingly, a lower proportion of adults have tried to lose weight during the past decade than during the mid-1980s to 1990s. The first-line treatment option for obesity is lifestyle intervention. Although this approach can decrease fat mass in the short term, these beneficial effects typically do not persist. If a large amount of weight loss is not an easily achievable goal, other goals that might motivate people with obesity to adopt a healthy lifestyle should be considered...
September 14, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28919064/genetics-of-obesity-what-genetic-association-studies-have-taught-us-about-the-biology-of-obesity-and-its-complications
#7
REVIEW
Mark O Goodarzi
Genome-wide association studies (GWAS) for BMI, waist-to-hip ratio, and other adiposity traits have identified more than 300 single-nucleotide polymorphisms (SNPs). Although there is reason to hope that these discoveries will eventually lead to new preventive and therapeutic agents for obesity, this will take time because such developments require detailed mechanistic understanding of how an SNP influences phenotype (and this information is largely unavailable). Fortunately, absence of functional information has not prevented GWAS findings from providing insights into the biology of obesity...
September 14, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28918909/progesterone-analogues-reduce-plasma-epstein-barr-virus-dna-load-and-improve-pain-control-in-recurrent-metastatic-nasopharyngeal-carcinoma-patients-under-supportive-care
#8
Chia-Yen Hung, Tung-Liang Lin, Yung-Chia Kuo, Chia-Hsun Hsieh, Hung-Ming Wang, Cheng-Lung Hsu
BACKGROUND: Progesterone analogues, such as megestrol acetate (MA) and medroxyprogesterone (MPA), have been used for the palliative care of cancer cachexia for decades and have proven to increase body weight and improve quality of life and performance status. The objective of this study was to determine the effect of progesterone analogue use on quality of life in terms of pain control, performance status, body weight gain, and Epstein-Barr virus (EBV) DNA load in recurrent/metastatic nasopharyngeal carcinoma (NPC) patients...
August 2017: Biomedical Journal
https://www.readbyqxmd.com/read/28917228/parenteral-nutrition-combined-with-enteral-feeding-improves-the-outcome-of-cancer-patients
#9
Pei-Chun Chao, Cheau-Feng Lin, Hui-Ju Chuang
BACKGROUND AND OBJECTIVES: This study investigated whether total parenteral nutrition combined with enteral nutrition is associated with improved biochemical and clinical outcomes in cancer patients with gastrointestinal dysfunction. METHODS AND STUDY DESIGN: From January to December 2014, the clinical data of 68 patients in a cancer ward were retrospectively collected, and these patients were classified into two groups according to nutrition delivery, through parenteral nutrition, combined with enteral nutrition more (group A) or less (group B) than 250 kcal/day...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28917003/effects-of-obesity-and-diabetes-on-rate-of-bone-density-loss
#10
W D Leslie, S N Morin, S R Majumdar, L M Lix
In this large registry-based study, women with diabetes had marginally greater bone mineral density (BMD) loss at the femoral neck but not at other measurement sites, whereas obesity was not associated with greater BMD loss. Our data do not support the hypothesis that rapid BMD loss explains the increased fracture risk associated with type 2 diabetes and obesity observed in prior studies. INTRODUCTION: Type 2 diabetes and obesity are associated with higher bone mineral density (BMD) which may be less protective against fracture than previously assumed...
September 15, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28916570/dietary-poly-phenols-brown-adipose-tissue-activation-and-energy-expenditure-a-narrative-review
#11
REVIEW
Laura Mele, Guillaume Bidault, Pedro Mena, Alan Crozier, Furio Brighenti, Antonio Vidal-Puig, Daniele Del Rio
The incidence of overweight and obesity has reached epidemic proportions, making the control of body weight and its complications a primary health problem. Diet has long played a first-line role in preventing and managing obesity. However, beyond the obvious strategy of restricting caloric intake, growing evidence supports the specific antiobesity effects of some food-derived components, particularly (poly)phenolic compounds. The relatively new rediscovery of active brown adipose tissue in adult humans has generated interest in this tissue as a novel and viable target for stimulating energy expenditure and controlling body weight by promoting energy dissipation...
September 2017: Advances in Nutrition
https://www.readbyqxmd.com/read/28916405/love-death-a-retrospective-and-prospective-follow-up-mortality-study-over-45-years
#12
Lena Lange, Barbra Zedler, Marcel A Verhoff, Markus Parzeller
BACKGROUND: Although sexual activity can cause moderate stress, it can cause natural death in individuals with pre-existing illness. The aim of this study was to identify additional pre-existing health problems, sexual practices, and potential circumstances that may trigger fatal events. METHODS: This medicolegal postmortem, retrospective, and prospective study is based on data of autopsies performed at the Institute of Legal Medicine of the University hospital, Goethe-University, Frankfurt/Main, Germany...
September 12, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28916383/heterologous-expression-and-structure-function-relationship-of-low-temperature-and-alkaline-active-protease-from-acinetobacter-sp-ihb-b-5011-mn12
#13
Richa Salwan, Vivek Sharma, Mohinder Pal, Ramesh Chand Kasana, Sudesh Kumar Yadav, Arvind Gulati
The gene encoding protease from Acinetobacter sp. IHB B 5011(MN12) was cloned and expressed in Escherichia coli BL21(DE3). The nucleotide sequence revealed 1323bp ORF encoding 441 amino acids protein with molecular weight 47.2kDa. The phylogenetic analysis showed clustering of Alp protease with subtilisin-like serine proteases of S8 family. The amino acid sequence was comprised of N-terminal signal peptide 1-21 amino acids, pre-peptide 22-143 amino acids, peptidase S8 domain 144-434 amino acids, and pro-peptide 435-441 amino acids at C-terminus...
September 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28916164/-analysis-of-clinical-relevance-applied-to-3methods-of-reducing-weight-in-overweight-or-obesity-followed-up-for-one-year
#14
M L Tárraga Marcos, J M Panisello Royo, J A Carbayo Herencia, N Rosich Domenech, J Alins Presas, E Castell Panisello, P J Tárraga López
OBJECTIVE: To analyse the effect of the use/implementation of 3methods to reduce weight in overweight or obese patients during one year of follow up. MATERIAL AND METHODS: The design corresponds to a double-blind, randomised, controlled clinical trial with 3arms, and 12 months of follow-up. Patients were randomised into 3intervention groups: obesity motivational intervention, with a nurse previously trained in motivational intervention by expert psychologists (G1; n=60); lower intensity consultation, non-motivational group, with digital platform support (G2; N=61), and a third group that received recommendations for weight loss and follow-up in Primary Care Clinic (G3; n=59)...
September 12, 2017: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/28914732/predictors-of-weight-related-quality-of-life-in-adolescents-who-are-overweight-or-obese
#15
Carolyn E Ievers-Landis, Oluwatomisin Olayinka, Christopher Burant, Shirley Moore
OBJECTIVE: Weight-related quality of life (WRQOL) is a type of health-related QOL that may serve as a patient-reported outcome of the potential burden of overweight. The present study uses structural equation modeling path analysis methods to examine body mass index (BMI) and other potential predictors of WRQOL components among adolescents who were overweight/obese from predominantly low-income, urban households. METHODS: Baseline data were obtained from 360 participants (10-13 year olds; 57...
September 13, 2017: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/28912152/distinct-effects-of-body-mass-index-and-waist-hip-ratio-on-risk-of-breast-cancer-by-joint-estrogen-and-progestogen-receptor-status-results-from-a-case-control-study-in-northern-and-eastern-china-and-implications-for-chemoprevention
#16
Fei Wang, Liyuan Liu, Shude Cui, Fuguo Tian, Zhimin Fan, Cuizhi Geng, Xuchen Cao, Zhenlin Yang, Xiang Wang, Hong Liang, Shu Wang, Hongchuan Jiang, Xuening Duan, Haibo Wang, Guolou Li, Qitang Wang, Jianguo Zhang, Feng Jin, Jinhai Tang, Liang Li, Shiguang Zhu, Wenshu Zuo, Zhongbing Ma, Fei Zhou, Lixiang Yu, Yujuan Xiang, Liang Li, Shuohao Shen, Zhigang Yu
BACKGROUND: Obesity is a consideration in the pharmacologic intervention for estrogen receptor (ER) positive (ER+) breast cancer risk. Body mass index (BMI) and waist/hip ratio (WHR) have demonstrated different effects on breast cancer risk in relation to estrogen receptor (ER) status, but the results have been inconsistent. Furthermore, the situation in Chinese women remains unclear. MATERIALS AND METHODS: We conducted a case-control study including 1,439 breast cancer cases in Northern and Eastern China...
September 14, 2017: Oncologist
https://www.readbyqxmd.com/read/28912051/the-relationship-between-coronary-artery-disease-risk-factors-and-carotid-intima-media-thickness-in-children
#17
Dan White, Rebecca Place, Timothy Michael, Eric Hoffman, Paul M Gordon, Paul Visich
OBJECTIVE: To determine the number of coronary artery disease risk factors and the individual coronary artery disease risk factors that have a negative influence on carotid intima-media thickness in children. STUDY DESIGN: One hundred and nineteen children (mean age 10.51 ± 0.52 years; 51% female) participated. Each subject was assessed for carotid intima-media thickness, total cholesterol, high-density lipoprotein cholesterol (HDL-C), glucose, body mass index (BMI), and resting blood pressure...
September 11, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28911179/deciphering-the-function-of-the-blunt-circadian-rhythm-of-melatonin-in-the-newborn-lamb-impact-on-adrenal-and-heart
#18
Maria Seron-Ferre, Claudia Torres-Farfan, Francisco J Valenzuela, Sebastian Castillo-Galan, Auristela Rojas, Natalia Mendez, Henry Reynolds, Guillermo J Valenzuela, Anibal J Llanos
Neonatal lambs, as with human and other neonates, have low arrhythmic endogenous levels of melatonin for several weeks until they start their own pineal rhythm of melatonin production at approximately 2 weeks of life. During pregnancy, daily rhythmic transfer of maternal melatonin to the fetus has important physiological roles in sheep, nonhuman primates, and rats. This melatonin rhythm provides a circadian signal and also participates in adjusting the physiology of several organs in preparation for extrauterine life...
September 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28910788/uremia-retention-molecules-and-clinical-outcomes
#19
Fellype Carvalho Barreto, Daniela Veit Barreto, Maria Eugênia Fernandes Canziani
Chronic kidney disease is characterized by the accumulation of organic compounds in the bloodstream that may exert a variety of toxic effects in the body. These compounds, collectively known as uremic toxins, may be classified according to their physicochemical properties as free water-soluble low molecular weight molecules, middle molecules or protein-bound uremic toxins. Most of these retention molecules, due to either their size and/or binding to protein, constitute a complex therapeutic challenge to the nephrologist, particularly in end-stage renal disease, because of their limited removal by conventional dialysis therapies...
2017: Contributions to Nephrology
https://www.readbyqxmd.com/read/28910146/management-of-ards-and-refractory-hypoxemia-a-multicenter-observational-study
#20
Erick H Duan, Neill Kj Adhikari, Frederick D'Aragon, Deborah J Cook, Sangeeta Mehta, Waleed Alhazzani, Ewan Goligher, Emmanuel Charbonney, Yaseen M Arabi, Tim Karachi, Alexis F Turgeon, Lori Hand, Qi Zhou, Peggy Austin, Jan Friedrich, Francois Lamontagne, François Lauzier, Rakesh Patel, John Muscedere, Richard Hall, Pierre Aslanian, Thomas Piraino, Martin Albert, Sean M Bagshaw, Mike Jacka, Gordon Wood, William Henderson, Delbert Dorscheid, Niall D Ferguson, Maureen O Meade
RATIONALE: Clinicians' current practice patterns in the management of acute respiratory distress syndrome (ARDS) and refractory hypoxemia are not well described. OBJECTIVES: To describe mechanical ventilation strategies and treatment adjuncts for adults with ARDS including refractory hypoxemia. METHODS: Prospective cohort study (March 2014-February 2015) of mechanically ventilated adults with moderate-to-severe ARDS requiring FiO2 ≥0.50 in 24 ICUs...
September 14, 2017: Annals of the American Thoracic Society
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