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https://www.readbyqxmd.com/read/28408613/air-pollution-and-the-incidence-of-ischaemic-and-haemorrhagic-stroke-in-the-south-london-stroke-register-a-case-cross-over-analysis
#1
B K Butland, R W Atkinson, S Crichton, B Barratt, S Beevers, A Spiridou, U Hoang, F J Kelly, C D Wolfe
BACKGROUND: Few European studies investigating associations between short-term exposure to air pollution and incident stroke have considered stroke subtypes. Using information from the South London Stroke Register for 2005-2012, we investigated associations between daily concentrations of gaseous and particulate air pollutants and incident stroke subtypes in an ethnically diverse area of London, UK. METHODS: Modelled daily pollutant concentrations based on a combination of measurements and dispersion modelling were linked at postcode level to incident stroke events stratified by haemorrhagic and ischaemic subtypes...
April 13, 2017: Journal of Epidemiology and Community Health
https://www.readbyqxmd.com/read/28388468/evaluating-the-diagnostic-utility-of-applying-a-machine-learning-algorithm-to-diffusion-tensor-mri-measures-in-individuals-with-major-depressive-disorder
#2
David M Schnyer, Peter C Clasen, Christopher Gonzalez, Christopher G Beevers
Using MRI to diagnose mental disorders has been a long-term goal. Despite this, the vast majority of prior neuroimaging work has been descriptive rather than predictive. The current study applies support vector machine (SVM) learning to MRI measures of brain white matter to classify adults with Major Depressive Disorder (MDD) and healthy controls. In a precisely matched group of individuals with MDD (n =25) and healthy controls (n =25), SVM learning accurately (74%) classified patients and controls across a brain map of white matter fractional anisotropy values (FA)...
March 23, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28343432/cognitive-and-affective-remediation-training-for-mood-disorders
#3
Richard J Porter, Åsa Hammar, Christopher G Beevers, Christopher R Bowie, Øystein O Nodtvedt, Andrew D Peckham, Greg J Siegle, Jordan A Tharp, Torill Ueland, Sophia Vinogradov, Sheri L Johnson
No abstract text is available yet for this article.
April 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28342846/new-studies-on-the-in%C3%A2-vitro-genotoxicity-of-sodium-molybdate-and-their-impact-on-the-overall-assessment-of-the-genotoxicity-of-molybdenum-substances
#4
Arne Burzlaff, Carol Beevers, Helen Pearce, Melvyn Lloyd, Kevin Klipsch
The potential of molybdenum substances to cause genotoxic effects has been studied previously. However, a review of existing in vitro data, including an assessment of relevance and reliability, has shown that inconsistent results have been observed in the past. To resolve the inconsistencies, new studies were performed with the highly soluble sodium molybdate dihydrate according to OECD test guidelines. In a bacterial reverse mutation assay sodium molybdate dihydrate did not induce reverse mutations in five strains of Salmonella typhimurium...
March 23, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28320342/enhanced-recovery-after-elective-caesarean-a-rapid-review-of-clinical-protocols-and-an-umbrella-review-of-systematic-reviews
#5
Ellena Corso, Daniel Hind, Daniel Beever, Gordon Fuller, Matthew J Wilson, Ian J Wrench, Duncan Chambers
BACKGROUND: The rate of elective Caesarean Section (CS) is rising in many countries. Many obstetric units in the UK have either introduced or are planning to introduce enhanced recovery (ER) as a means of reducing length of stay for planned CS. However, to date there has been very little evidence produced regarding the necessary components of ER for the obstetric population. We conducted a rapid review of the composition of published ER pathways for elective CS and undertook an umbrella review of systematic reviews evaluating ER components and pathways in any surgical setting...
March 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28316879/a-preliminary-study-of-genetic-variation-in-the-dopaminergic-and-serotonergic-systems-and-genome-wide-additive-genetic-effects-on-depression-severity-and-treatment-response
#6
Rohan H C Palmer, Christopher G Beevers, John E McGeary, Leslie A Brick, Valerie S Knopik
No abstract text is available yet for this article.
January 2017: Clinical Psychological Science
https://www.readbyqxmd.com/read/28230390/effectiveness-of-an-internet-intervention-deprexis-for-depression-in-a-united-states-adult-sample-a-parallel-group-pragmatic-randomized-controlled-trial
#7
Christopher G Beevers, Rahel Pearson, James S Hoffman, A Alban Foulser, Jason Shumake, Björn Meyer
OBJECTIVE: To examine the effectiveness of an Internet intervention for depression with a randomized, controlled trial in a large sample of adults recruited from the United States. METHOD: The current study examines the effectiveness of Deprexis, an Internet treatment for depression that was provided with relatively minimal support. There were 376 treatment-seeking adults (mean age = 32 years; 74% female; 77% Caucasian, 7% Asian, 7% multiple races, 4% African American, and 11% Hispanic/Latino) with elevated depression (Quick Inventory of Depressive Symptoms-Self-Report [QIDS-SR] > = 10) who were randomized to receive an 8-week course of treatment immediately (n = 285) or after an 8-week delay (n = 91; i...
April 2017: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/28062790/advice-and-guidance-on-flexible-working
#8
(no author information available yet)
Paul Beevers is from Legal Assistance Direct, which provides a free legal helpline to BVA members. Here, he discusses flexible working.
January 7, 2017: Veterinary Record
https://www.readbyqxmd.com/read/27902732/predictors-of-current-and-longer-term-patterns-of-abundance-of-american-pikas-ochotona-princeps-across-a-leading-edge-protected-area
#9
Lucas Moyer-Horner, Erik A Beever, Douglas H Johnson, Mark Biel, Jami Belt
American pikas (Ochotona princeps) have been heralded as indicators of montane-mammal response to contemporary climate change. Pikas no longer occupy the driest and lowest-elevation sites in numerous parts of their geographic range. Conversely, pikas have exhibited higher rates of occupancy and persistence in Rocky Mountain and Sierra Nevada montane 'mainlands'. Research and monitoring efforts on pikas across the western USA have collectively shown the nuance and complexity with which climate will often act on species in diverse topographic and climatic contexts...
2016: PloS One
https://www.readbyqxmd.com/read/27898945/effects-of-timing-and-duration-of-test-period-and-diet-type-on-intake-and-feed-efficiency-of-charolais-sired-cattle
#10
C J Cassady, T L Felix, J E Beever, D W Shike
Objectives of this experiment were to: 1) determine appropriate test length, timing, and repeatability of DMI, ADG, and efficiency over different biological time points; 2) determine the efficacy of using decoupled performance and intake data to generate accurate feed efficiency measures; and 3) determine the relationship between forage-and grain-feed efficiency measures. Over 2 yr, Charolais crossbred heifers ( = 308) and steers ( = 320) were fed for two 70 d periods and DMI, ADG, and 12th rib fat thickness were recorded...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27811334/effect-of-exhaust-and-nonexhaust-related-components-of-particulate-matter-on-long-term-survival-after-stroke
#11
Anita Desikan, Siobhan Crichton, Uy Hoang, Benjamin Barratt, Sean D Beevers, Frank J Kelly, Charles D A Wolfe
BACKGROUND AND PURPOSE: Outdoor air pollution represents a potentially modifiable risk factor for stroke. We examined the link between ambient pollution and mortality up to 5 years poststroke, especially for pollutants associated with vehicle exhaust. METHODS: Data from the South London Stroke Register, a population-based register covering an urban, multiethnic population, were used. Hazard ratios (HR) for a 1 interquartile range increase in particulate matter <2...
December 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27799556/precise-gene-editing-paves-the-way-for-derivation-of-mannheimia-haemolytica-leukotoxin-resistant-cattle
#12
Sudarvili Shanthalingam, Ahmed Tibary, Jonathan E Beever, Poothapillai Kasinathan, Wendy C Brown, Subramaniam Srikumaran
Signal peptides of membrane proteins are cleaved by signal peptidase once the nascent proteins reach the endoplasmic reticulum. Previously, we reported that, contrary to the paradigm, the signal peptide of ruminant CD18, the β subunit of β2 integrins, is not cleaved and hence remains intact on mature CD18 molecules expressed on the surface of ruminant leukocytes. Leukotoxin secreted by Mannheimia (Pasteurella) haemolytica binds to the intact signal peptide and causes cytolysis of ruminant leukocytes, resulting in acute inflammation and lung tissue damage...
November 15, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27786527/infants-early-visual-attention-and-social-engagement-as-developmental-precursors-to-joint-attention
#13
Brenda Salley, Stephen J Sheinkopf, A Rebecca Neal-Beevers, Elena J Tenenbaum, Cynthia L Miller-Loncar, Ed Tronick, Linda L Lagasse, Seetha Shankaran, Henrietta Bada, Charles Bauer, Toni Whitaker, Jane Hammond, Barry M Lester
This study examined infants' early visual attention (at 1 month of age) and social engagement (4 months) as predictors of their later joint attention (12 and 18 months). The sample (n = 325), drawn from the Maternal Lifestyle Study, a longitudinal multicenter project conducted at 4 centers of the National Institute of Child Health and Human Development Neonatal Research Network, included high-risk (cocaine-exposed) and matched noncocaine-exposed infants. Hierarchical regressions revealed that infants' attention orienting at 1 month significantly predicted more frequent initiating joint attention at 12 (but not 18) months of age...
November 2016: Developmental Psychology
https://www.readbyqxmd.com/read/27706935/the-london-hybrid-exposure-model-lhem-improving-human-exposure-estimates-to-no2-and-pm2-5-in-an-urban-setting
#14
James David Smith, Christina Mitsakou, Nutthida Kitwiroon, Ben M Barratt, Heather A Walton, Jonathon G Taylor, Hugh Ross Anderson, Frank J Kelly, Sean D Beevers
Here we describe the development of the London Hybrid Exposure Model (LHEM), which calculates exposure of the Greater London population to outdoor air pollution sources, in-buildings, in-vehicles and outdoors, using survey data of when and where people spend their time. For comparison and to estimate exposure misclassification we compared Londoners LHEM exposure with exposure at the residential address, a commonly used exposure metric in epidemiological research. In 2011, the mean annual LHEM exposure to outdoor sources was estimated to be 37÷ lower for PM2...
October 6, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27593899/genotoxicity-assessment-of-the-flavouring-agent-perillaldehyde
#15
Cheryl A Hobbs, Sean V Taylor, Carol Beevers, Melvyn Lloyd, Rachael Bowen, Lucinda Lillford, Robert Maronpot, Shim-Mo Hayashi
Perillaldehyde, a natural monocyclic terpenoid found most abundantly in the herb perilla, has a long history of use as a flavouring ingredient to add spiciness and citrus taste to foods. Previously, it was judged to be safe by several international expert panels. To confirm the safety of flavourings placed on the European Union list of flavourings, perillaldehyde was selected by the European Food Safety Authority as a representative of a subgroup of alicyclic aldehyde flavouring substances to be evaluated for genotoxic potential...
November 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27591803/air-pollution-ethnicity-and-telomere-length-in-east-london-schoolchildren-an-observational-study
#16
Robert T Walton, Ian S Mudway, Isobel Dundas, Nadine Marlin, Lee C Koh, Layla Aitlhadj, Tom Vulliamy, Jeenath B Jamaludin, Helen E Wood, Ben M Barratt, Sean Beevers, David Dajnak, Aziz Sheikh, Frank J Kelly, Chris J Griffiths, Jonathan Grigg
BACKGROUND: Short telomeres are associated with chronic disease and early mortality. Recent studies in adults suggest an association between telomere length and exposure to particulate matter, and that ethnicity may modify the relationship. However associations in children are unknown. OBJECTIVES: We examined associations between air pollution and telomere length in an ethnically diverse group of children exposed to high levels of traffic derived pollutants, particularly diesel exhaust, and to environmental tobacco smoke...
November 2016: Environment International
https://www.readbyqxmd.com/read/27500587/mechanistic-variables-can-enhance-predictive-models-of-endotherm-distributions-the-american-pika-under-current-past-and-future-climates
#17
Paul D Mathewson, Lucas Moyer-Horner, Erik A Beever, Natalie J Briscoe, Michael Kearney, Jeremiah M Yahn, Warren P Porter
How climate constrains species' distributions through time and space is an important question in the context of conservation planning for climate change. Despite increasing awareness of the need to incorporate mechanism into species distribution models (SDMs), mechanistic modeling of endotherm distributions remains limited in this literature. Using the American pika (Ochotona princeps) as an example, we present a framework whereby mechanism can be incorporated into endotherm SDMs. Pika distribution has repeatedly been found to be constrained by warm temperatures, so we used Niche Mapper, a mechanistic heat-balance model, to convert macroclimate data to pika-specific surface activity time in summer across the western United States...
August 8, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27492689/a-response-to-evaluation-of-pain
#18
Lee J Beever, Elvin R Kulendra, Richard L Meeson
No abstract text is available yet for this article.
September 20, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27491674/the-assessment-of-depression-in-people-with-multiple-sclerosis-a-systematic-review-of-psychometric-validation-studies
#19
Daniel Hind, Daphne Kaklamanou, Dan Beever, Rosie Webster, Ellen Lee, Michael Barkham, Cindy Cooper
BACKGROUND: The prevalence of depression in people with multiple sclerosis (PwMS) is high; however, symptoms common to both conditions makes measurement difficult. There is no high quality overview of validation studies to guide the choice of depression inventory for this population. METHODS: A systematic review of studies validating the use of generic depression inventories in people with MS was conducted using MEDLINE and PsycINFO. Studies validating the use of depression inventories in PwMS and published in English were included; validation studies of tests for cognitive function and general mental health were excluded...
2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27453731/bdnf-val66met-polymorphism-as-a-moderator-of-exercise-enhancement-of-smoking-cessation-treatment-in-anxiety-vulnerable-adults
#20
Jasper A J Smits, Mark B Powers, David Rosenfield, Michael J Zvolensky, Jolene Jacquart, Michelle L Davis, Christopher G Beevers, Bess H Marcus, Timothy S Church, Michael W Otto
BACKGROUND: Exercise interventions facilitate odds of quit success among high-anxiety sensitive adults smokers. We examined the dependency of these benefits on the genetic BDNF Val66Met (rs6265) polymorphism; individuals who are Met carriers have lower BDNF responses and reduced associated benefits from exercise. Accordingly, we hypothesized that the efficacy of vigorous exercise for smoking cessation would be specific to high-anxiety sensitive Val/Val carriers. METHODS: Participants were adults (N=55) of European ancestry who had participated in a randomized controlled trial comparing a smoking cessation program augmented with exercise vs...
March 2016: Mental Health and Physical Activity
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