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Janna N Vrijsen, Justin Dainer-Best, Sara M Witcraft, Santiago Papini, Paula Hertel, Christopher G Beevers, Eni S Becker, Jasper A J Smits
Memory bias is a risk factor for depression. In two independent studies, the efficacy of one CBM-Memory session on negative memory bias and depressive symptoms was tested in vulnerable samples. We compared positive to neutral (control) CBM-Memory trainings in highly-ruminating individuals (N = 101) and individuals with elevated depressive symptoms (N = 100). In both studies, participants studied positive, neutral, and negative Swahili words paired with their translations. In five study-test blocks, they were then prompted to retrieve either only the positive or neutral translations...
March 15, 2018: Cognition & Emotion
Lee James Beever, Kirsty Giles, Richard Lawrence Meeson
OBJECTIVES:  To quantify and evaluate risks of complications attributable to external skeletal fixator (ESF) usage in dogs. METHODS:  A retrospective review of medical records following ESF placement. RESULTS:  Case records of 97 dogs were reviewed; fixator-associated complications occurred in 79/97 dogs. Region of ESF placement was significantly associated with complication development ( p  = 0.005), not complication type ( p  = 0...
February 2018: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Michael C Mullarkey, Igor Marchetti, Christopher G Beevers
Experiencing depression symptoms, even at mild to moderate levels, is associated with maladaptive outcomes for adolescents. We used network analysis to evaluate which symptoms (and associations between symptoms) are most central to adolescent depression. Participants were part of a large, diverse community sample (N = 1,409) of adolescents between 13 and 19 years of age. Network analysis was used to identify the most central symptoms (nodes) and associations between symptoms (edges) assessed by the Children's Depression Inventory...
March 13, 2018: Journal of Clinical Child and Adolescent Psychology
Catharine A Rhodes, D Gareth Beevers, David Churchill
To assess the feasibility of a prospective randomised trial of ambulatory blood pressure monitoring (ABPM) versus clinic blood pressure (CBP) readings for managing pregnancy hypertension. The primary outcome measure was admission to hospital. The secondary measures were number of antenatal attendances, use of anti-hypertensive drugs and duration of hospital stay. In general, there were no statistical differences between the two groups including the primary outcome, the rate of hospital admission p=0.76. 89% of participants would undergo ABPM in future pregnancies...
January 2018: Pregnancy Hypertension
Mark A T Blaskovich, Karl A Hansford, Yujing Gong, Mark S Butler, Craig Muldoon, Johnny X Huang, Soumya Ramu, Alberto B Silva, Mu Cheng, Angela M Kavanagh, Zyta Ziora, Rajaratnam Premraj, Fredrik Lindahl, Tanya A Bradford, June C Lee, Tomislav Karoli, Ruby Pelingon, David J Edwards, Maite Amado, Alysha G Elliott, Wanida Phetsang, Noor Huda Daud, Johan E Deecke, Hanna E Sidjabat, Sefetogi Ramaologa, Johannes Zuegg, Jason R Betley, Andrew P G Beevers, Richard A G Smith, Jason A Roberts, David L Paterson, Matthew A Cooper
The public health threat posed by a looming 'post-antibiotic' era necessitates new approaches to antibiotic discovery. Drug development has typically avoided exploitation of membrane-binding properties, in contrast to nature's control of biological pathways via modulation of membrane-associated proteins and membrane lipid composition. Here, we describe the rejuvenation of the glycopeptide antibiotic vancomycin via selective targeting of bacterial membranes. Peptide libraries based on positively charged electrostatic effector sequences are ligated to N-terminal lipophilic membrane-insertive elements and then conjugated to vancomycin...
January 2, 2018: Nature Communications
Rachel B Smith, Daniela Fecht, John Gulliver, Sean D Beevers, David Dajnak, Marta Blangiardo, Rebecca E Ghosh, Anna L Hansell, Frank J Kelly, H Ross Anderson, Mireille B Toledano
Objective  To investigate the relation between exposure to both air and noise pollution from road traffic and birth weight outcomes. Design  Retrospective population based cohort study. Setting  Greater London and surrounding counties up to the M25 motorway (2317 km2 ), UK, from 2006 to 2010. Participants  540 365 singleton term live births. Main outcome measures  Term low birth weight (LBW), small for gestational age (SGA) at term, and term birth weight. Results  Average air pollutant exposures across pregnancy were 41 μg/m3 nitrogen dioxide (NO2 ), 73 μg/m3 nitrogen oxides (NOx ), 14 μg/m3 particulate matter with aerodynamic diameter <2...
December 5, 2017: BMJ: British Medical Journal
Khoa Nguyen, Bertha Ben Khallouq, Amanda Schuster, Christopher Beevers, Nyla Dil, Denise Kay, Jonathan D Kibble, David M Harris
Most assessments of physiology in medical school use multiple choice tests that may not provide information about a student's critical thinking (CT) process. There are limited performance assessments, but high-fidelity patient simulations (HFPS) may be a feasible platform. The purpose of this pilot study was to determine whether a group's CT process could be observed over a series of HFPS. An instrument [Critical Thinking Skills Rating Instrument CTSRI)] was designed with the IDEAS framework. Fifteen groups of students participated in three HFPS that consisted of a basic knowledge quiz and introduction, HFPS session, and debriefing...
December 1, 2017: Advances in Physiology Education
Adrian Gerard Barnett, Ian Stewart, Andrea Beevers, John F Fraser, David Platts
OBJECTIVE: To examine whether providing thermal clothing improved the health of patients with heart failure during winter. DESIGN: Parallel group randomised controlled trial. SETTING: Large public hospital in Brisbane during winter 2016. PARTICIPANTS: 91 patients with systolic or diastolic heart failure who were over 50 years old. INTERVENTION: 47 patients were randomised to receive thermal clothes (socks, top and hat) and 44 received usual care...
October 8, 2017: BMJ Open
Justin Dainer-Best, Logan T Trujillo, David M Schnyer, Christopher G Beevers
This study investigated the link between self-reference and attentional engagement in adults with (n=22) and without (HC; n=24) Major Depressive Disorder (MDD). Event-related potentials (ERPs) were recorded while participants completed the Self-Referent Encoding Task (SRET). MDD participants endorsed significantly fewer positive words and more negative words as self-descriptive than HC participants. A whole-scalp data analysis technique revealed that the MDD participants had larger difference wave (negative words minus positive words) ERP amplitudes from 380 to 1000ms across posterior sites, which positively correlated with number of negative words endorsed...
October 2017: Biological Psychology
Jonathan Beever, Nicolae Morar
No abstract text is available yet for this article.
September 2017: American Journal of Bioethics: AJOB
Lynda Rutherford, Lee Beever, Mieghan Bruce, Gert Ter Haar
The aims of this observational, analytical, retrospective study were to (i) obtain computed tomographic (CT) cricoid dimensions (height, width, and transverse-sectional area), (ii) compare the cricoid dimensions between brachycephalic and mesaticephalic breeds, and (iii) compare cricoid cartilage dimensions between dogs without and affected with brachycephalic airway syndrome. The study is important to help to further evaluate and understand the anatomical components of brachycephalic airway syndrome. Measurements were performed in 147 brachycephalic and 59 mesaticephalic dogs...
July 30, 2017: Veterinary Radiology & Ultrasound
A B Kelani, H Moumouni, A W Issa, H Younsaa, Hmu Fokou, R Sani, S Sanoussi, L J Denholm, J E Beever, M Catala
No abstract text is available yet for this article.
November 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Joel E Beevers, Mang Ching Lai, Emma Collins, Heather D E Booth, Federico Zambon, Laura Parkkinen, Jane Vowles, Sally A Cowley, Richard Wade-Martins, Tara M Caffrey
The H1 haplotype of the microtubule-associated protein tau (MAPT) locus is genetically associated with neurodegenerative diseases, including Parkinson's disease (PD), and affects gene expression and splicing. However, the functional impact on neurons of such expression differences has yet to be fully elucidated. Here, we employ extended maturation phases during differentiation of induced pluripotent stem cells (iPSCs) into mature dopaminergic neuronal cultures to obtain cultures expressing all six adult tau protein isoforms...
August 8, 2017: Stem Cell Reports
Alena Shantsila, Eduard Shantsila, D Gareth Beevers, Gregory Y H Lip
OBJECTIVE: Malignant hypertension represents a high-risk condition and there are scarce data on current clinical patterns of this condition. The aim of the study is to identify the clinical and demographic factors associated with poor outcome. METHODS: The data collected from 1958 to May 2016 included a total of 351 patients whose 5-year survival status was known: 221 white Caucasians (63%, age 51 ± 13 years, 64% male), 83 African-Caribbeans (24%, 45 ± 11 years, 61% male), and 47 South Asians (13%, 42 ± 11 years, 74% male)...
November 2017: Journal of Hypertension
Lee Beever, Kirsty Giles, Richard Meeson
OBJECTIVES: The objective of this study was to quantify complications associated with external skeletal fixators (ESFs) in cats and to identify potential risk factors. METHODS: A retrospective review of medical records and radiographs following ESF placement was performed. RESULTS: Case records of 140 cats were reviewed; fixator-associated complications (FACs) occurred in 19% of cats. The region of ESF placement was significantly associated with complication development...
July 2017: Journal of Feline Medicine and Surgery
Christopher M Seabury, David L Oldeschulte, Mahdi Saatchi, Jonathan E Beever, Jared E Decker, Yvette A Halley, Eric K Bhattarai, Maral Molaei, Harvey C Freetly, Stephanie L Hansen, Helen Yampara-Iquise, Kristen A Johnson, Monty S Kerley, JaeWoo Kim, Daniel D Loy, Elisa Marques, Holly L Neibergs, Robert D Schnabel, Daniel W Shike, Matthew L Spangler, Robert L Weaber, Dorian J Garrick, Jeremy F Taylor
BACKGROUND: Single nucleotide polymorphism (SNP) arrays for domestic cattle have catalyzed the identification of genetic markers associated with complex traits for inclusion in modern breeding and selection programs. Using actual and imputed Illumina 778K genotypes for 3887 U.S. beef cattle from 3 populations (Angus, Hereford, SimAngus), we performed genome-wide association analyses for feed efficiency and growth traits including average daily gain (ADG), dry matter intake (DMI), mid-test metabolic weight (MMWT), and residual feed intake (RFI), with marker-based heritability estimates produced for all traits and populations...
May 18, 2017: BMC Genomics
Andrew V Beddows, Nutthida Kitwiroon, Martin L Williams, Sean D Beevers
Gaussian process emulation techniques have been used with the Community Multiscale Air Quality model, simulating the effects of input uncertainties on ozone and NO2 output, to allow robust global sensitivity analysis (SA). A screening process ranked the effect of perturbations in 223 inputs, isolating the 30 most influential from emissions, boundary conditions (BCs), and reaction rates. Community Multiscale Air Quality (CMAQ) simulations of a July 2006 ozone pollution episode in the UK were made with input values for these variables plus ozone dry deposition velocity chosen according to a 576 point Latin hypercube design...
June 6, 2017: Environmental Science & Technology
B K Butland, R W Atkinson, S Crichton, B Barratt, S Beevers, A Spiridou, U Hoang, F J Kelly, C D Wolfe
BACKGROUND: Few European studies investigating associations between short-term exposure to air pollution and incident stroke have considered stroke subtypes. Using information from the South London Stroke Register for 2005-2012, we investigated associations between daily concentrations of gaseous and particulate air pollutants and incident stroke subtypes in an ethnically diverse area of London, UK. METHODS: Modelled daily pollutant concentrations based on a combination of measurements and dispersion modelling were linked at postcode level to incident stroke events stratified by haemorrhagic and ischaemic subtypes...
July 2017: Journal of Epidemiology and Community Health
David M Schnyer, Peter C Clasen, Christopher Gonzalez, Christopher G Beevers
Using MRI to diagnose mental disorders has been a long-term goal. Despite this, the vast majority of prior neuroimaging work has been descriptive rather than predictive. The current study applies support vector machine (SVM) learning to MRI measures of brain white matter to classify adults with Major Depressive Disorder (MDD) and healthy controls. In a precisely matched group of individuals with MDD (n =25) and healthy controls (n =25), SVM learning accurately (74%) classified patients and controls across a brain map of white matter fractional anisotropy values (FA)...
June 30, 2017: Psychiatry Research
Richard J Porter, Åsa Hammar, Christopher G Beevers, Christopher R Bowie, Øystein O Nodtvedt, Andrew D Peckham, Greg J Siegle, Jordan A Tharp, Torill Ueland, Sophia Vinogradov, Sheri L Johnson
No abstract text is available yet for this article.
April 2017: Australian and New Zealand Journal of Psychiatry
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