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https://www.readbyqxmd.com/read/29454196/sexually-transmitted-infections-and-immune-activation-among-hiv-infected-but-virally-suppressed-youth-on-antiretroviral-therapy
#1
Tanya L Kowalczyk Mullins, Su X Li, James Bethel, Maureen M Goodenow, Stephanie Hudey, John W Sleasman
BACKGROUND: Human immunodeficiency virus (HIV) infection is associated with chronic immune activation, and concurrent sexually transmitted infections (STIs) may increase immune activation. OBJECTIVES: Because HIV-infected youth are at high risk of STIs and little is known about the impact of STIs on immune activation in HIV-infected youth, we conducted an exploratory study examining the association between STIs and systemic inflammation and immune activation among HIV-infected adolescents...
February 7, 2018: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29453551/characterization-of-hiv-recent-infection-among-high-risk-men-at-public-sti-clinics-in-mumbai
#2
Hong-Ha M Truong, Robin Fatch, Robert M Grant, Meenakshi Mathur, Sameer Kumta, Hemangi Jerajani, Timothy A Kellogg, Christina P Lindan
We examined associations with HIV recent infection and estimated transmitted drug resistance (TDR) prevalence among 3345 men at sexually transmitted infection clinics in Mumbai (2002-2005). HIV seroincidence was 7.92% by the BED-CEIA and was higher at a clinic located near brothels (12.39%) than at a hospital-based clinic (3.94%). HIV recent infection was associated with a lifetime history of female sex worker (FSW) partners, HSV-2, genital warts, and gonorrhea. TDR prevalence among recent infection cases was 5...
February 16, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29451274/helicase-primase-inhibitor-amenamevir-for-herpesvirus-infection-towards-practical-application-for-treating-herpes-zoster
#3
K Shiraki
Valacyclovir and famciclovir enabled successful systemic therapy for treating herpes simplex virus (HSV) and varicella zoster virus (VZV) infection by their phosphorylation with viral thymidine kinase. Helicase-primase inhibitors (HPIs) inhibit the progression of the replication fork, an initial step in DNA synthesis to separate the double strand into two single strands. The HPIs amenamevir and pritelivir have a novel mechanism of action, once-daily administration with nonrenal excretory characteristics, and clinical efficacy for genital herpes...
November 2017: Drugs of Today
https://www.readbyqxmd.com/read/29447697/herpes-simplex-virus-1-vp22-inhibits-aim2-dependent-inflammasome-activation-to-enable-efficient-viral-replication
#4
Yuhei Maruzuru, Takeshi Ichinohe, Ryota Sato, Kensuke Miyake, Tokuju Okano, Toshihiko Suzuki, Takumi Koshiba, Naoto Koyanagi, Shumpei Tsuda, Mizuki Watanabe, Jun Arii, Akihisa Kato, Yasushi Kawaguchi
The AIM2 inflammasome is activated by DNA, leading to caspase-1 activation and release of pro-inflammatory cytokines interleukin 1β (IL-1β) and IL-18, which are critical mediators in host innate immune responses against various pathogens. Some viruses employ strategies to counteract inflammasome-mediated induction of pro-inflammatory cytokines, but their in vivo relevance is less well understood. Here we show that the herpes simplex virus 1 (HSV-1) tegument protein VP22 inhibits AIM2-dependent inflammasome activation...
February 14, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29447144/quickstats-age-adjusted-trends-in-the-prevalence-of-herpes-simplex-virus-type-1-hsv-1-and-herpes-simplex-virus-type-2-hsv-2-among-adolescents-and-adults-aged-14-49-years-united-states-1999-2000-through-2015-2016
#5
(no author information available yet)
During 2015-2016, the age-adjusted prevalence of HSV-1 was 48.1% among adolescents and adults aged 14-49 years (50.9% for females and 45.2% for males). Prevalence was higher for females than males in most 2-year periods from 1999-2000 to 2015-2016. Also during 2015-2016, the age-adjusted prevalence of HSV-2 for those aged 14-49 years was 12.1% (15.9% among females compared to 8.2% among males) and was higher for females than males for all 2-year periods. Prevalence significantly declined from 1999-2000 through 2015-2016 for HSV-1 and HSV-2 among both males and females...
February 16, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29445241/is-early-life-exposure-to-polyomaviruses-and-herpesviruses-associated-with-obesity-indices-and-metabolic-traits-in-childhood
#6
Marianna Karachaliou, Silvia de Sanjose, Tim Waterboer, Theano Roumeliotaki, Maria Vassilaki, Katerina Sarri, Vasiliki Leventakou, Marina Vafeiadi, Georgia Chalkiadaki, Eftichia Stiakaki, Angelika Michel, Michael Pawlita, Manolis Kogevinas, Leda Chatzi
BACKGROUND: Evidence for an infectious origin of obesity is emerging. We explored whether common viruses were associated with obesity and metabolic traits. METHODS: We used cross-sectional (n = 674) and prospective (n = 440) data from children participating at the 4 and 6 years of age follow-up in the Rhea birth cohort. Presence of IgG antibodies to ten polyomaviruses (BKPyV, JCPyV, KIPyV, WUPyV, HPyV6, HPyV7, TSPyV, MCPyV, HPyV9, and HPyV10) and four herpesviruses (EBV, CMV, HSV-1, and HSV-2) were measured at age 4...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29444978/an-off-target-effect-of-bx795-blocks-herpes-simplex-virus-type-1-infection-of-the-eye
#7
Dinesh Jaishankar, Abraam M Yakoub, Tejabhiram Yadavalli, Alex Agelidis, Neel Thakkar, Satvik Hadigal, Joshua Ames, Deepak Shukla
Herpes simplex virus type 1 (HSV-1) causes recurrent mucocutaneous lesions in the eye that may advance to corneal blindness. Nucleoside analogs exemplified by acyclovir (ACV) form the primary class of antiherpetic drugs, but this class suffers limitations due to the emergence of viral resistance and other side effects. While studying the molecular basis of ocular HSV-1 infection, we observed that BX795, a commonly used inhibitor of TANK-binding kinase 1 (TBK1), strongly suppressed infection by multiple strains of HSV-1 in transformed and primary human cells, cultured human and animal corneas, and a murine model of ocular infection...
February 14, 2018: Science Translational Medicine
https://www.readbyqxmd.com/read/29444835/retrospective-review-of-t-pallidum-pcr-and-serology-results-are-both-tests-necessary
#8
Anna Brischetto, Ian Gassiep, David Whiley, Robert Norton
There has been a resurgence of syphilis diagnoses in Australia. We investigated whether our Treponema pallidum polymerase chain reaction (PCR) test provides any additional diagnostic information over syphilis serology (chemi-luminescence immunoassay (CMIA), Treponema pallidum particle agglutination (TPPA) and rapid reagin (RPR) flocculation test). A retrospective audit was conducted of all T. pallidum PCR requests that came through our laboratory from January 2010 to June 2017; data collected included age, gender, site of swab, T...
February 14, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29442994/prevalence-of-herpes-simplex-virus-type-1-and-type-2-in-persons-aged-14-49-united-states-2015-2016
#9
Geraldine McQuillan, Deanna Kruszon-Moran, Elaine W Flagg, Ryne Paulose-Ram
During 2015-2016, prevalence of herpes simplex virus type 1 (HSV-1) was 47.8%, and prevalence of herpes simplex virus type 2 (HSV-2) was 11.9%. Prevalence of both HSV-1 and HSV-2 increased with age. Prevalence of both HSV-1 and HSV-2 was higher among females than males. Prevalence of HSV-1 was highest among Mexican- American persons and lowest among non-Hispanic white persons. HSV-2 prevalence was highest among non-Hispanic black persons and lowest among non-Hispanic Asian persons. Prevalence of both HSV-1 and HSV-2 decreased from 1999-2000 to 2015-2016 (from 59...
February 2018: NCHS Data Brief
https://www.readbyqxmd.com/read/29439749/nmda-receptor-autoimmunity-in-mania-following-hsv-encephalitis
#10
Graham Blackman, Nicholas Moran, Eli Silber, Christopher Symeon, Franz Brunnhuber, Asif Mazumder, Fatima Jaffer, Thomas Pollak
No abstract text is available yet for this article.
February 14, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29437965/ctcf-binding-sites-in-the-hsv-1-genome-display-site-specific-ctcf-occupation-protein-recruitment-and-insulator-function
#11
Shannan D Washington, Farhana Musarrat, Monica K Ertel, Gregory L Backes, Donna M Neumann
There are seven conserved CTCF binding domains in the HSV-1 genome. These binding sites individually flank the LAT and the IE gene regions, suggesting that CTCF insulators differentially control transcriptional domains in HSV-1 latency. In this work, we show that two CTCF binding motifs in HSV-1 display enhancer-blocking in a cell-type specific manner. We found that CTCF binding to the latent HSV-1 genome was LAT-dependent and the quantity of bound CTCF was site-specific. Following reactivation, CTCF eviction was dynamic suggesting each CTCF site was independently regulated...
February 7, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29437883/cerebrospinal-fluid-reference-values-for-young-infants-undergoing-lumbar-puncture
#12
Joanna Thomson, Heidi Sucharew, Andrea T Cruz, Lise E Nigrovic, Stephen B Freedman, Aris C Garro, Fran Balamuth, Rakesh D Mistry, Joseph L Arms, Paul T Ishimine, Dina M Kulik, Mark I Neuman, Samir S Shah
OBJECTIVES: To determine age-specific reference values and quantify age-related changes for cerebrospinal fluid (CSF) white blood cell (WBC) counts and protein and glucose concentrations in infants ≤60 days of age. METHODS: This multicenter, cross-sectional study included infants ≤60 days old with CSF cultures and complete CSF profiles obtained within 24 hours of presentation. Those with conditions suspected or known to cause abnormal CSF parameters (eg, meningitis) and those with a hospital length of stay of >72 hours were excluded...
February 2, 2018: Pediatrics
https://www.readbyqxmd.com/read/29434285/generation-of-a-dual-target-safe-inexpensive-microbicide-that-protects-against-hiv-1-and-hsv-2-disease
#13
Christina Farr Zuend, John F Nomellini, John Smit, Marc S Horwitz
HSV-2 infection is a significant health problem and a major co-morbidity factor for HIV-1 acquisition, increasing risk of infection 2-4 fold. Condom based prevention strategies for HSV-2 and HIV-1 have not been effective at stopping the HIV-1 pandemic, indicating that alternative prevention strategies need to be investigated. We have previously developed an inexpensive HIV-1 specific microbicide that utilizes the S-layer mediated display capabilities of Caulobacter crescentus, and have shown that recombinant C...
February 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29429998/zdhhc11-modulates-innate-immune-response-to-dna-virus-by-mediating-mita-irf3-association
#14
Ying Liu, Qian Zhou, Li Zhong, Heng Lin, Ming-Ming Hu, Yan Zhou, Hong-Bing Shu, Shu Li
MITA is a central adaptor in innate immune responses to DNA viruses. The mechanisms responsible for recruitment of downstream kinase TBK1 and the transcription factor IRF3 to MITA remains enigmatic. Here we identified ZDHHC11, a member of DHHC palmitoyl transferase family, as a positive regulator of DNA virus-triggered signaling. Overexpression of ZDHHC11 activated the IFN-β promoter, while ZDHHC11-deficiency specifically impaired DNA virus HSV-1-induced transcription of downstream antiviral genes. Zdhhc11-/- mice exhibited lower serum cytokine levels and higher lethality after HSV-1 infection...
February 12, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29427675/relevance-of-non-synonymous-thymidine-kinase-mutations-for-antiviral-resistance-of-recombinant-herpes-simplex-virus-type-2-strains
#15
Anne-Kathrin Brunnemann, Anja Hoffmann, Stefanie Deinhardt-Emmer, Claus-Henning Nagel, Ruben Rose, Helmut Fickenscher, Andreas Sauerbrei, Andi Krumbholz
Therapy or prophylaxis of herpes simplex virus type 2 (HSV-2) infections with the nucleoside analog aciclovir (ACV) can lead to the emergence of drug-resistant HSV-2 strains, particularly in immunocompromised patients. In this context, multiple amino acid (aa) changes can accumulate in the ACV-converting viral thymidine kinase (TK) which hampers sequence-based diagnostics significantly. In this study, the so far unknown or still doubted relevance of several individual aa changes for drug resistance in HSV-2 was clarified...
February 7, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29427299/herpes-simplex-virus-type-2-igg-antibodies-in-sera-of-umbilical-cord-as-a-proxy-for-placental-infection-in-asymptomatic-pregnant-women
#16
Fabiana Finger-Jardim, Emiliana Claro Avila, Vanusa Pousada da Hora, Paula Costa Dos Santos, Carla Vitola Gonçalves, Gil Mor, Ana Maria Barral de Martinez, Marcelo Alves Soares
PROBLEM: Herpes simplex virus type 2 (HSV-2) infection is one of the most prevalent diseases worldwide and is mainly sexually transmitted. When infecting pregnant women, HSV-2 is able to infect the placenta, can reach the fetus, and may affect the fetal development. We sought to determine the prevalence of HSV-2 infection and reactivation in asymptomatic pregnant women, the correlation between IgG in the maternal circulation and cord blood, and the correlation between circulating IgG, placental, and newborn infection (blood cord)...
February 10, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29426904/trim56-mediated-monoubiquitination-of-cgas-for-cytosolic-dna-sensing
#17
Gil Ju Seo, Charlotte Kim, Woo-Jin Shin, Ella H Sklan, Hyungjin Eoh, Jae U Jung
Intracellular nucleic acid sensors often undergo sophisticated modifications that are critical for the regulation of antimicrobial responses. Upon recognition of DNA, the cytosolic sensor cyclic GMP-AMP (cGAMP) synthase (cGAS) produces the second messenger cGAMP, which subsequently initiates downstream signaling to induce interferon-αβ (IFNαβ) production. Here we report that TRIM56 E3 ligase-induced monoubiquitination of cGAS is important for cytosolic DNA sensing and IFNαβ production to induce anti-DNA viral immunity...
February 9, 2018: Nature Communications
https://www.readbyqxmd.com/read/29420244/chronic-lymphocytic-leukaemia-with-necrotic-herpetic-adenitis-an-elusive-clinical-condition
#18
Roma Srivastava, Doreen Griswold, Muhammad Omer Jamil
Herpes simplex virus (HSV) adenitis is a rare but important cause of morbidity in immunocompromised patients. Chronic lymphocytic leukaemia (CLL)/Small lymphocytic lymphoma (SLL) is an indolent disease which impairs the cellular and humoral immunity, predisposing patients to a myriad of infections. Clinically, herpetic adenitis can mimic large cell (Richter's) transformation in patients with CLL. To date, less than 30 cases of HSV adenitis have been reported in the literature. We report a case of a patient with CLL with no prior history of HSV infection, who presented with rapidly enlarging lymph nodes after initial response to idelalisib raising the suspicion of Richter's transformation...
February 2, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29409366/oral-shedding-of-hsv-1-and-ebv-and-oral-manifestations-in-paediatric-chronic-kidney-disease-patients-and-renal-transplant-recipients
#19
Rubens Caliento, Dmitry José de Santana Sarmento, Érika Mont'alverne Pereira Silva, Tânia Regina Tozetto-Mendoza, Priscila Lie Tobouti, Vanda Benini, Paulo Henrique Braz-Silva, Marina Gallottini
OBJECTIVE: Previous research demonstrated that salivary shedding of HSV-1 and EBV occurs often in adult renal transplant recipients, but there is a lack of studies on the presence of them in the saliva of paediatric population. Therefore, the objective of this study is to describe oral characteristics and to compare the shedding profile of HSV-1 and EBV in the saliva of children with renal transplant to that of chronic kidney disease patients and controls. METHODS: This is a cross-sectional study involving 100 children, being 25 renal transplant recipients, 25 chronic kidney disease patients and 50 healthy children...
February 6, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29408422/concordance-of-self-reported-hormonal-contraceptive-use-and-presence-of-exogenous-hormones-in-serum-among-african-women
#20
Maria Pyra, Jairam R Lingappa, Renee Heffron, David W Erikson, Steven W Blue, Rena C Patel, Kavita Nanda, Helen Rees, Nelly R Mugo, Nicole L Davis, Athena P Kourtis, Jared M Baeten
OBJECTIVES: Studies that rely on self-report to investigate the relationship between hormonal contraceptive use and HIV acquisition and transmission, as well as other health outcomes, could have compromised results due to misreporting. We determined the frequency of misreported hormonal contraceptive use among African women with and at risk for HIV. STUDY DESIGN: We tested 1102 archived serum samples from 664 African women who had participated in prospective HIV prevention studies...
February 2, 2018: Contraception
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