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https://www.readbyqxmd.com/read/29052561/a-bayesian-stepwise-discriminant-model-for-predicting-risk-factors-of-preterm-premature-rupture-of-membranes-a-case-control-study
#1
Li-Xia Zhang, Yang Sun, Hai Zhao, Na Zhu, Xing-De Sun, Xing Jin, Ai-Min Zou, Yang Mi, Ji-Ru Xu
BACKGROUND: Preterm premature rupture of membrane (PPROM) can lead to serious consequences such as intrauterine infection, prolapse of the umbilical cord, and neonatal respiratory distress syndrome. Genital infection is a very important risk which closely related with PPROM. The preliminary study only made qualitative research on genital infection, but there was no deep and clear judgment about the effects of pathogenic bacteria. This study was to analyze the association of infections with PPROM in pregnant women in Shaanxi, China, and to establish Bayesian stepwise discriminant analysis to predict the incidence of PPROM...
October 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/29046461/human-embryonic-stem-cell-derived-neurons-are-highly-permissive-for-varicella-zoster-virus-lytic-infection
#2
Tomohiko Sadaoka, Cindi L Schwartz, Labchan Rajbhandari, Arun Venkatesan, Jeffrey I Cohen
Varicella-zoster virus (VZV) is highly cell-associated when grown in culture and has a much higher (4,000 to 20,000-fold increased) particle-to-plaque forming unit (PFU) ratio in vitro than herpes simplex virus (HSV). In contrast, VZV is highly infectious in vivo by airborne transmission. Neurons are major targets for VZV in vivo, in which the virus can establish latency and reactivate to produce infectious virus. Using neurons derived from human embryonic stem cells (hESC) and cell-free wild-type (WT) VZV, we demonstrate that neurons are nearly 100 times more permissive for WT VZV infection than very early passage human embryonic lung cells or MRC-5 diploid human fibroblasts, the cells used for vaccine production or virus isolation...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29046455/extended-synaptotagmin-1-interacts-with-the-herpes-simplex-virus-type-1-glycoprotein-m-and-negatively-modulates-virus-induced-membrane-fusion
#3
Imane El Kasmi, Bita Khadivjam, Miki Lackman, Johanne Duron, Eric Bonneil, Pierre Thibault, Roger Lippé
Enveloped viruses typically encode their own fusion machinery to enter cells. Herpesviruses are particular as they fuse with a number of cellular compartments throughout their life cycle. As the uncontrolled mixing of the host membranes should be avoided in these events, the tight regulation of the viral fusion machinery is critical. While studying the herpes simplex virus type 1 glycoprotein gM, we identified the cellular protein E-Syt1 (Extended synaptotagmin-1) as an interaction partner. This took place in both infected and transfected cells, suggesting other viral proteins were not required for this interaction...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29046447/a-functional-carboxy-terminal-fluorescent-protein-fusion-to-pseudorabies-virus-small-capsid-protein-vp26
#4
Ian B Hogue, Jolie Jean, Andrew D Esteves, Nikhila S Tanneti, Julian Scherer, Lynn W Enquist
Fluorescent protein fusions to herpesvirus capsids have proven to be a valuable method to study virus particle transport in living cells. Fluorescent protein fusions to the amino terminus of small capsid protein VP26 are the most widely-used method to visualize Pseudorabies Virus (PRV) and Herpes Simplex Virus (HSV) particles in living cells. However, these fusion proteins do not incorporate to full occupancy, and have modest effects on virus replication and pathogenesis. Recent cryo electron microscopy studies have revealed that herpesvirus small capsid proteins bind to capsids via their amino terminus, whereas the carboxy terminus is unstructured and may therefore better tolerate fluorescent protein fusions...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29046357/structural-and-thermodynamic-analyses-reveal-critical-features-of-glycopeptide-recognition-by-the-human-pilr%C3%AE-immune-cell-receptor
#5
Atsushi Furukawa, Kosuke Kakita, Tomoki Yamada, Mikihiro Ishizuka, Jiro Sakamoto, Nanao Hatori, Naoyoshi Maeda, Fumina Ohsaka, Takashi Saitoh, Takao Nomura, Kimiko Kuroki, Hisanori Nambu, Hisashi Arase, Shigeki Matsunaga, Masahiro Anada, Toyoyuki Ose, Shunichi Hashimoto, Katsumi Maenaka
Before entering host cells, herpes simplex virus-1 (HSV-1) uses its envelope glycoprotein B (gB) to bind paired immunoglobulin-like type 2 receptor α (PILRα) on immune cells. PILRα belongs to the Siglec (sialic acid (SA)-binding immunoglobulin-like lectin)-like family, members of which bind SA. PILRα is the only Siglec member to recognize not only the sialylated O-linked sugar T antigen (sTn) but also its attached peptide region. We previously determined the crystal structure of PILRα complexed with the sTn-linked glycopeptide of gB, revealing the simultaneous recognition of sTn and peptide by the receptor...
October 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29044877/sustained-fxn-expression-in-dorsal-root-ganglia-from-a-nonreplicative-genomic-hsv-1-vector
#6
Maria Ventosa, Zetang Wu, Filip Lim
BACKGROUND: Friedreich's ataxia (FA) is an autosomal recessive neurodegenerative disease caused by mutations in the frataxin gene (FXN), which lead to reduced levels of the essential mitochondrial protein frataxin. Currently there is no effective cure. METHODS: With the aim of developing a gene therapy for FA neuropathology, here we describe the construction and preliminary characterization of a high capacity nonreplicative genomic herpes simplex virus type 1 vector (H24B-FXNlac vector) carrying a reduced version of the human FXN genomic locus, comprising the 5 kb promoter and the FXN cDNA with the inclusion of intron 1...
October 17, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/29043989/antiviral-screening-of-four-plant-extracts-against-acyclovir-resistant-herpes-simplex-virus-type-1
#7
Masoud Parsania, Mohammad-Bagher Rezaee, Seyed Hamidreza Monavari, Kamkar Jaimand, Seyed Milad Mousavi-Jazayeri, Mehdi Razazian, Mohammad Hossein Nadjarha
Herpes simplex virus type 1 (HSV-1) causes serious infections particularly in immunocompromised patients. Methanolic extract of four plants were evaluated for their anti-viral effects against acyclovir resistant HSV-1 in HeLa cell line. The 50% cytotoxic concentration (CC50) as well as the effective minimal cytotoxic concentration of each plant extract were evaluated by MTT assay. Antiviral effects of the plant extracts on HSV-1 were examined at different concentrations of the extract. The effective minimal cytotoxic concentration was evaluated at different times of virus replication after infection...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29037754/antiviral-effects-of-lactobacillus-crispatus-against-hsv-2-in-mammalian-cell-lines
#8
Elham Mousavi, Manoochehr Makvandi, Ali Teimoori, Angila Ataei, Shokouh Ghafari, Alireza Samarbaf-Zadeh
BACKGROUND: Herpes simplex virus type 2 (HSV-2) infectious disease is one of the most common viral sexually transmitted diseases. As regards, vaginal lactobacilli play an important role in protecting host against the urogenital pathogens; here we assessed the potential antiviral activity of Lactobacillus crispatus against HSV-2 infection in vitro. METHODS: Both Vero and HeLa cell lines were treated by L. crispatus before, during and after HSV-2 infection. The pre-incubation assay was also performed for the evaluating of virus adsorption by L...
October 13, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29036805/determining-the-igm-and-igg-antibodies-titer-against-hsv1-hsv2-and-cmv-in-the-serum-of-schizophrenia-patients
#9
Masome Mohagheghi, Mohammad Yousef Alikhani, Mohammad Taheri, Mohammad Mahdi Eftekharian
Schizophrenia is a destructive clinical syndrome with diverse mental pathologies. Different mechanisms and factors have a role in this disease. A possible mechanism is that teratogenic viruses cause brain changes and results in the disease appearance. The schizophrenia patients were diagnosed by psychologists and with the consent of patients, five CC of venous blood was drawn. Than Serum samples were isolated and immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies against herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2) and cytomegalovirus (CMV) were quantified by ELISA sandwich kit...
September 8, 2017: Human Antibodies
https://www.readbyqxmd.com/read/29036216/herpesviruses-in-etiopathogenesis-of-aggressive-periodontitis-a-meta-analysis-based-on-case-control-studies
#10
Fei Li, Ce Zhu, Feng-Ying Deng, May Chun Mei Wong, Hai-Xia Lu, Xi-Ping Feng
OBJECTIVE: Previous studies have found that herpesviruses are associated with aggressive periodontitis (AgP). However, these findings are controversial. This meta-analysis was aimed at clarifying the association between herpesviruses and AgP. METHODS: We identified eligible case-control studies evaluating the association between herpesviruses and AgP from PubMed and Embase databases in October 2015. Original data were extracted and quality assessment was done. Overall odds ratios (ORs) and 95% confidence intervals (CIs) were estimated...
2017: PloS One
https://www.readbyqxmd.com/read/29034313/newly-characterized-murine-undifferentiated-sarcoma-models-sensitive-to-virotherapy-with-oncolytic-hsv-1-m002
#11
Eric K Ring, Rong Li, Blake P Moore, Li Nan, Virginia M Kelly, Xiaosi Han, Elizabeth A Beierle, James M Markert, Jianmei W Leavenworth, G Yancey Gillespie, Gregory K Friedman
Despite advances in conventional chemotherapy, surgical techniques, and radiation, outcomes for patients with relapsed, refractory, or metastatic soft tissue sarcomas are dismal. Survivors often suffer from lasting morbidity from current treatments. New targeted therapies with less toxicity, such as those that harness the immune system, and immunocompetent murine sarcoma models to test these therapies are greatly needed. We characterized two new serendipitous murine models of undifferentiated sarcoma (SARC-28 and SARC-45) and tested their sensitivity to virotherapy with oncolytic herpes simplex virus 1 (HSV-1)...
December 15, 2017: Molecular Therapy Oncolytics
https://www.readbyqxmd.com/read/29033632/review-of-viral-encephalitis-cases-seen-at-a-tertiary-care-center-in-turkey-focus-on-herpes-simplex-type-1
#12
Beyza Çiftçi Kavaklioğlu, Eda Çoban, Aysu Şen, Elif Söylemezoğlu, Mehmet Ali Aldan, Dilek Atakli, Aysun Soysal
INTRODUCTION: The objective of this study was to determine the incidence of herpes simplex encephalitis (HSE), known as the most common, potentially mortal, and treatable cause of sporadic encephalitis, in a sample Turkish population. METHODS: The demographic, clinical, laboratory, imaging, electrophysiology, and polymerase chain reaction (PCR) DNA results of patients examined with a pre-diagnosis of encephalitis were retrospectively examined. RESULTS: A total of 68 patients were included in the study...
September 2017: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/29031157/a-european-multi-centre-external-quality-assessment-eqa-study-on-phenotypic-and-genotypic-methods-used-for-herpes-simplex-virus-hsv-drug-resistance-testing
#13
Baharak Afshar, David F Bibby, Renata Piorkowska, Natasha Ohemeng-Kumi, Robert Snoeck, Graciela Andrei, Sarah Gillemot, Florence Morfin, Emilie Frobert, Sonia Burrel, David Boutolleau, Brendan Crowley, Jean L Mbisa
BACKGROUND: Herpes Simplex Virus (HSV) drug resistance is a significant public health concern among immunocompromised individuals. Phenotypic assays are considered the gold standard method for detecting HSV drug resistance. However, plaque reduction assays (PRAs) are technically demanding, often with long turnaround times of up to four weeks. In contrast, genotypic tests can be performed within a few days. OBJECTIVES: The development and coordination of the first European External Quality Assessment (EQA) study to evaluate phenotypic and genotypic methods used for HSV drug resistance testing in specialised reference laboratories...
October 6, 2017: Journal of Clinical Virology: the Official Publication of the Pan American Society for Clinical Virology
https://www.readbyqxmd.com/read/29026166/virus-and-host-specific-differences-in-oral-human-herpesvirus-shedding-kinetics-among-ugandan-women-and-children
#14
Laura Matrajt, Soren Gantt, Bryan T Mayer, Elizabeth M Krantz, Jackson Orem, Anna Wald, Lawrence Corey, Joshua T Schiffer, Corey Casper
Human herpesviruses (HHV) establish lifelong latent infection and are transmitted primarily via shedding at mucosal surfaces. Each HHV causes a unique spectrum of disease depending on the infected individual's age and immunity. We collected weekly oral swabs from young children and mothers in 32 Ugandan households for a median of one year. We characterized kinetics of oral shedding during primary and chronic infection for each virus. Cytomegalovirus (CMV), Epstein-Barr virus (EBV), and HHV-6 were shed at high rates following primary infection...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025419/strong-associations-between-national-prevalence-of-various-stis-suggests-sexual-network-connectivity-is-a-common-underpinning-risk-factor
#15
Chris Kenyon
BACKGROUND: If national peak Human Immunodeficiency Virus (HIV) prevalence is positively associated with the prevalence of other sexually transmitted infections (STIs) from before or early on in the HIV epidemics this would suggest common underlying drivers. METHODS: Pearson's correlations were calculated between the prevalence of seven STIs at a country-level: chlamydia, gonorrhoea, trichomoniasis, syphilis, bacterial vaginosis, herpes simplex virus-2 (HSV-2) and HIV...
October 12, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29022511/metabolism-of-nucleosides-and-nucleotides-prodrugs
#16
Coralie De Schutter, Maryam Ehteshami, Emily T Hammond, Franck Amblard, Raymond F Schinazi
BACKGROUND: Modified nucleoside and nucleotide analogs are now the cornerstone of antiviral and anticancer chemotherapies. However, these compounds are not active on their own and need, after entering the cell, to be metabolized to their active 5'-triphosphate form. METHOD: Limitations of these metabolic processes led to development of nucleoside/nucleotide prodrugs in which nucleosides are masked with different groups that can be intracellularly cleaved either chemically or enzymatically...
October 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29016638/penile-coital-injuries-in-men-decline-after-circumcision-results-from-a-prospective-study-of-recently-circumcised-and-uncircumcised-men-in-western-kenya
#17
Nelli Westercamp, Supriya D Mehta, Walter Jaoko, Timothy A Okeyo, Robert C Bailey
BACKGROUND: Penile coital injuries are one of the suggested mechanisms behind the increased risk of HIV among uncircumcised men. We evaluated the prevalence and correlates of self-reported penile coital injuries in a longitudinal community-based cohort of young (18-24 years old), newly circumcised and uncircumcised men in Western Kenya. METHODS: Self-reported penile coital injuries were assessed at baseline, 6, 12, 18 and 24 months of follow-up, and were defined as scratches, cuts or abrasions during sex, penile soreness during sex, and skin of the penis bleeding during sex...
2017: PloS One
https://www.readbyqxmd.com/read/29016635/hiv-human-herpesvirus-co-infections-impact-on-tryptophan-kynurenine-pathway-and-immune-reconstitution
#18
Siew Hwei Yap, Noor Kamila Abdullah, Megan McStea, Kozo Takayama, Meng Li Chong, Elisa Crisci, Marie Larsson, Iskandar Azwa, Adeeba Kamarulzaman, Kok Hoong Leong, Yin Ling Woo, Reena Rajasuriar
BACKGROUND: Co-infections with human herpesvirus (HHV) have been associated with residual chronic inflammation in antiretroviral (ART)-treated human immunodeficiency virus (HIV)-infected individuals. However, the role of HHV in modulating the tryptophan-kynurenine pathway and clinical outcomes in HIV-infected individuals is poorly understood. Thus, we investigated the seroprevalence of four common HHVs among treated HIV-infected participants and their impact on kynurenine/tryptophan (K/T) ratio and long-term CD4 T-cell recovery in HIV/HHV co-infected participants...
2017: PloS One
https://www.readbyqxmd.com/read/28991189/translational-implication-of-galectin-9-in-the-pathogenesis-and-treatment-of-viral-infection
#19
REVIEW
Jenn-Haung Lai, Shue-Fen Luo, Mei-Yi Wang, Ling-Jun Ho
The interaction between galectin-9 and its receptor, Tim-3, triggers a series of signaling events that regulate immune responses. The expression of galectin-9 has been shown to be increased in a variety of target cells of many different viruses, such as hepatitis C virus (HCV), hepatitis B virus (HBV), herpes simplex virus (HSV), influenza virus, dengue virus (DENV), and human immunodeficiency virus (HIV). This enhanced expression of galectin-9 following viral infection promotes significant changes in the behaviors of the virus-infected cells, and the resulting events tightly correlate with the immunopathogenesis of the viral disease...
October 8, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28987880/heparin-functionalized-polymer-graft-surface-eluting-mk2-inhibitory-peptide-to-improve-hemocompatibility-and-anti-neointimal-activity
#20
Yunki Lee, Phuong Le Thi, Gyeung Mi Seon, Seung Bae Ryu, Colleen M Brophy, YongTae Kim, Jong-Chul Park, Ki Dong Park, Joyce Cheung-Flynn, Hak-Joon Sung
The leading cause of synthetic graft failure includes thrombotic occlusion and intimal hyperplasia at the site of vascular anastomosis. Herein, we report a co-immobilization strategy of heparin and potent anti-neointimal drug (Mitogen Activated Protein Kinase II inhibitory peptide; MK2i) by using a tyrosinase-catalyzed oxidative reaction for preventing thrombotic occlusion and neointimal formation of synthetic vascular grafts. The binding of heparin-tyramine polymer (HT) onto the polycarprolactone (PCL) surface enhanced blood compatibility with significantly reduced protein absorption (64...
October 4, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
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