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https://www.readbyqxmd.com/read/29778292/high-prevalence-of-clinically-important-echocardiographic-abnormalities-in-patients-with-a-normal-electrocardiogram-referred-for-transthoracic-echocardiography
#1
Jeremy R Stone, Linda Lee, Jack P Ward, R Parker Ward
BACKGROUND: Normal electrocardiographic (ECG) results have been reported to be associated with a low prevalence of structural heart disease and thus may preclude the need for transthoracic echocardiographic (TTE) imaging. The goal of this study was to determine the prevalence of important TTE abnormalities in patients with a normal ECG referred for TTE imaging. METHODS: Consecutive electrocardiograms over 6 months were reviewed. Patients with a normal ECG who underwent TTE imaging within 30 days formed the study group...
May 16, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29777255/inhibition-of-sialidase-activity-and-cellular-invasion-by-the-bacterial-vaginosis-pathogen-gardnerella-vaginalis
#2
G Govinden, J L Parker, K L Naylor, A M Frey, D O C Anumba, G P Stafford
Bacterial vaginosis is a genital tract infection, thought to be caused by transformation of a lactobacillus-rich flora to a dysbiotic microbiota enriched in mixed anaerobes. The most prominent of these is Gardnerella vaginalis (GV), an anaerobic pathogen that produces sialidase enzyme to cleave terminal sialic acid residues from human glycans. Notably, high sialidase activity is associated with preterm birth and low birthweight. We explored the potential of the sialidase inhibitor Zanamavir against GV whole cell sialidase activity using methyl-umbelliferyl neuraminic acid (MU-NANA) cleavage assays, with Zanamavir causing a 30% reduction in whole cell GV sialidase activity (p < 0...
May 18, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29776604/biased-agonism-antagonism-of-cardiovascular-gpcrs-for-heart-failure-therapy
#3
Victoria L Desimine, Katie A McCrink, Barbara M Parker, Shelby L Wertz, Jennifer Maning, Anastasios Lymperopoulos
G protein-coupled receptors (GPCRs) are among the most important drug targets currently used in clinic, including drugs for cardiovascular indications. We now know that, in addition to activating heterotrimeric G protein-dependent signaling pathways, GPCRs can also activate G protein-independent signaling, mainly via the βarrestins. The major role of βarrestin1 and -2, also known as arrestin2 or -3, respectively, is to desensitize GPCRs, i.e., uncoupled them from G proteins, and to subsequently internalize the receptor...
2018: International Review of Cell and Molecular Biology
https://www.readbyqxmd.com/read/29775431/national-health-and-nutrition-examination-survey-estimation-procedures-2011-2014
#4
Te-Ching Chen, Jennifer D Parker, Jason Clark, Hee-Choon Shin, Jennifer R Rammon, Vicki L Burt
This report describes the methods used to create NHANES 2011-2014 sample weights and variance units for the public-use data files, including sample weights for selected subsamples, such as the fasting subsample. The impacts of sample design changes on estimation for NHANES 2011-2014 and the addition of the NHANES National Youth Fitness Survey (NNYFS) 2012 are described. Approaches that data users can employ to modify sample weights when combining survey cycles or when combining subsamples are also included.
January 2018: Vital and Health Statistics. Series 2, Data Evaluation and Methods Research
https://www.readbyqxmd.com/read/29773767/the-role-of-brincidofovir-in-preparation-for-a-potential-smallpox-outbreak
#5
Scott A Foster, Scott Parker, Randall Lanier
Smallpox (variola) virus is considered a Category A bioterrorism agent due to its ability to spread rapidly and the high morbidity and mortality rates associated with infection. Current recommendations recognize the importance of oral antivirals and call for having at least two smallpox antivirals with different mechanisms of action available in the event of a smallpox outbreak. Multiple antivirals are recommended due in large part to the propensity of viruses to become resistant to antiviral therapy, especially monotherapy...
October 30, 2017: Viruses
https://www.readbyqxmd.com/read/29772202/rnp-granule-assembly-via-ataxin-2-disordered-domains-is-required-for-long-term-memory-and-neurodegeneration
#6
Baskar Bakthavachalu, Joern Huelsmeier, Indulekha P Sudhakaran, Jens Hillebrand, Amanjot Singh, Arnas Petrauskas, Devasena Thiagarajan, M Sankaranarayanan, Laura Mizoue, Eric N Anderson, Udai Bhan Pandey, Eric Ross, K VijayRaghavan, Roy Parker, Mani Ramaswami
Human Ataxin-2 is implicated in the cause and progression of amyotrophic lateral sclerosis (ALS) and type 2 spinocerebellar ataxia (SCA-2). In Drosophila, a conserved atx2 gene is essential for animal survival as well as for normal RNP-granule assembly, translational control, and long-term habituation. Like its human homolog, Drosophila Ataxin-2 (Atx2) contains polyQ repeats and additional intrinsically disordered regions (IDRs). We demonstrate that Atx2 IDRs, which are capable of mediating liquid-liquid phase transitions in vitro, are essential for efficient formation of neuronal mRNP assemblies in vivo...
May 16, 2018: Neuron
https://www.readbyqxmd.com/read/29772066/3d-specific-absorption-rate-estimation-from-high-intensity-focused-ultrasound-sonications-using-the-green-s-function-heat-kernel
#7
Nicholas J Freeman, Henrik Odéen, Dennis L Parker
PURPOSE: Evaluate a numerical inverse Green's function method of deriving specific absorption rates (SARs) from high intensity focused ultrasound (HIFU) sonications given tissue parameters (thermal conductivity, specific heat capacity, and mass density) and 3-D magnetic resonance imaging (MRI) temperature measurements. METHODS: SAR estimates were evaluated using simulations and MR temperature measurements from HIFU sonications. For simulations, a "true" SAR was calculated using the hybrid angular spectrum method for ultrasound simulations...
May 17, 2018: Medical Physics
https://www.readbyqxmd.com/read/29768942/updated-meta-review-of-evidence-on-support-for-carers
#8
Jane Dalton, Sian Thomas, Melissa Harden, Alison Eastwood, Gillian Parker
Objective To update a 2010 meta-review of systematic reviews of effective interventions to support carers of ill, disabled, or older adults. In this article, we report the most promising interventions based on the best available evidence. Methods Rapid meta-review of systematic reviews published from January 2009 to 2016. Results Sixty-one systematic reviews were included (27 high quality, 25 medium quality, and nine low quality). The quality of reviews has improved since the original review, but primary studies remain limited in quality and quantity...
January 1, 2018: Journal of Health Services Research & Policy
https://www.readbyqxmd.com/read/29767774/common-and-rare-variants-genetic-association-analysis-of-cigarettes-per-day-among-ever-smokers-in-copd-cases-and-controls
#9
Sharon M Lutz, Brittni Frederiksen, Ferdouse Begum, Merry-Lynn McDonald, Michael H Cho, Brian Hobbs, Margaret M Parker, Dawn L DeMeo, Craig P Hersh, Marissa Eringher, Kendra Young, Lai Jiang, Marilyn G Foreman, Greg L Kinney, Barry J Make, David A Lomas, Per Bakke, Amund Gulsvik, James D Crapo, Edwin K Silverman, Terri H Beaty, John E Hokanson
Introduction: Cigarette smoking is a major environmental risk factor for many diseases, including chronic obstructive pulmonary disease (COPD). There are shared genetic influences on cigarette smoking and COPD. Genetic risk factors for cigarette smoking in cohorts enriched for COPD are largely unknown. Methods: We performed genome-wide association analyses for average cigarettes per day (CPD) across the COPDGene Non-Hispanic White (NHW) (n=6,659) and African American (AA) (n=3,260), GenKOLS (n=1,671), and ECLIPSE (n=1,942) cohorts...
May 15, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29767424/cultural-adaptations-of-evidence-based-home-visitation-models-in-tribal-communities
#10
Vanessa Y Hiratsuka, Myra E Parker, Jenae Sanchez, Rebecca Riley, Debra Heath, Julianna C Chomo, Moushumi Beltangady, Michelle Sarche
The Tribal Maternal, Infant, and Early Childhood Home Visiting (Tribal MIECHV) Program provides federal grants to tribes, tribal consortia, tribal organizations, and urban Indian organizations to implement evidence-based home-visiting services for American Indian and Alaska Native (AI/AN) families. To date, only one evidence-based home-visiting program has been developed for use in AI/AN communities. The purpose of this article is to describe the steps that four Tribal MIECHV Programs took to assess community needs, select a home-visiting model, and culturally adapt the model for use in AI/AN communities...
May 16, 2018: Infant Mental Health Journal
https://www.readbyqxmd.com/read/29766765/control-of-transitions-between-locomotor-like-and-paw-shake-like-rhythms-in-a-model-of-a-multistable-central-pattern-generator
#11
Jessica Rae Parker, Brain Bondy, Boris I Prilutsky, Gennady S Cymbalyuk
The ability of the same neuronal circuit to control different motor functions is an actively debated concept. Previously, we have shown in a model that a single multistable CPG could produce two different rhythmic motor patterns, slow and fast, corresponding to cat locomotion and paw-shaking. A locomotor-like rhythm (~2 Hz) and a paw-shake-like rhythm (~10 Hz) did coexist and, by applying a single pulse of current, we could switch the CPG from one regime to another (Bondy et al. 2016). Here, we investigate roles of slow intrinsic ionic currents in this multistability...
May 16, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29765658/nest-size-is-predicted-by-female-identity-and-the-local-environment-in-the-blue-tit-cyanistes-caeruleus-but-is-not-related-to-the-nest-size-of-the-genetic-or-foster-mother
#12
Louis G O'Neill, Timothy H Parker, Simon C Griffith
The potential for animals to respond to changing climates has sparked interest in intraspecific variation in avian nest structure since this may influence nest microclimate and protect eggs and offspring from inclement weather. However, there have been relatively few large-scale attempts to examine variation in nests or the determinates of individual variation in nest structure within populations. Using a set of mostly pre-registered analyses, we studied potential predictors of variation in the size of a large sample (803) of blue tit ( Cyanistes caeruleus ) nests across three breeding seasons at Wytham Woods, UK...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29765636/vibrational-spectroscopy-of-metal-methanesulfonates-m-na-cs-cu-ag-cd
#13
Stewart F Parker, Lisha Zhong
In this work, we have used a combination of vibrational spectroscopy (infrared, Raman and inelastic neutron scattering) and periodic density functional theory to investigate six metal methanesulfonate compounds that exhibit four different modes of complexation of the methanesulfonate ion: ionic, monodentate, bidentate and pentadentate. We found that the transition energies of the modes associated with the methyl group (C-H stretches and deformations, methyl rock and torsion) are essentially independent of the mode of coordination...
April 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29764351/fifo-fifo-and-off-to-work-we-woe
#14
Gordon B Parker Ao
No abstract text is available yet for this article.
May 21, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29761832/psychophysical-evaluation-of-a-tactile-display-based-on-coin-motors
#15
H Christiaan Stronks, Daniel J Parker, Ashley Stacey, Nick Barnes
Tactile vision substitution devices present visual images as tactile representations on the skin. In this study we have tested the performance of a prototype 96-tactor vibrotactile using a subset of 64 tactors. We have determined the tactile spatial acuity and intensity discrimination in 14 naïve subjects. Spatial acuity was determined using a grating acuity task. Subjects could successfully identify the orientation of horizontal and vertical gratings with an average psychophysical threshold of 120 mm. When diagonal gratings were included in the analysis, the median performance dropped below psychophysical threshold, but was still significantly above chance at gratings of 142 mm wide...
May 15, 2018: Artificial Organs
https://www.readbyqxmd.com/read/29760670/validating-the-copenhagen-psychosocial-questionnaire-copsoq-ii-using-set-esem-identifying-psychosocial-risk-factors-in-a-sample-of-school-principals
#16
Theresa Dicke, Herbert W Marsh, Philip Riley, Philip D Parker, Jiesi Guo, Marcus Horwood
School principals world-wide report high levels of strain and attrition resulting in a shortage of qualified principals. It is thus crucial to identify psychosocial risk factors that reflect principals' occupational wellbeing. For this purpose, we used the Copenhagen Psychosocial Questionnaire (COPSOQ-II), a widely used self-report measure covering multiple psychosocial factors identified by leading occupational stress theories. We evaluated the COPSOQ-II regarding factor structure and longitudinal, discriminant, and convergent validity using latent structural equation modeling in a large sample of Australian school principals ( N = 2,049)...
2018: Frontiers in Psychology
https://www.readbyqxmd.com/read/29759735/preoperative-serum-st2-level-predicts-acute-kidney-injury-after-adult-cardiac-surgery
#17
Kevin W Lobdell, Devin M Parker, Donald S Likosky, Michael Rezaee, Moritz Wyler von Ballmoos, Shama S Alam, Sherry Owens, Heather Thiessen-Philbrook, Todd MacKenzie, Jeremiah R Brown
OBJECTIVE: The purpose of this study was to evaluate the relationship between preoperative levels of serum soluble ST2 (ST2) and acute kidney injury (AKI) after cardiac surgery. Previous research has shown that biomarkers facilitate the prediction of AKI and other complications after cardiac surgery. METHODS: Preoperative ST2 proteins were measured in 1498 patients undergoing isolated coronary artery bypass graft surgery at 8 hospitals participating in the Northern New England Biomarker Study from 2004 to 2007...
April 11, 2018: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29758910/assessing-the-effect-of-chlorinated-hydrocarbon-degradation-in-aquitards-on-plume-persistence-due-to-back-diffusion
#18
Philipp Wanner, Beth L Parker, Daniel Hunkeler
This modeling study aims to investigate how reactive processes in aquitards impact plume persistence in adjacent aquifers. For that purpose the migration of a trichloroethene (TCE) plume in an aquifer originating from dense non-aqueous phase liquid (DNAPL) source dissolution and back-diffusion from an underlying reactive aquitard was simulated in a 2D-numerical model. Two aquitard degradation scenarios were modeled considering one-step degradation from TCE to cis-dichloroethene (cDCE): a uniform (constant degradation with aquitard depth) and a non-uniform scenario (decreasing degradation with aquitard depth) and were compared with a no-degradation scenario...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29757897/coagulation-defects-in-the-cirrhotic-patient-undergoing-liver-transplantation
#19
Arabesque Parker, Constantine J Karvellas
Patients with cirrhosis undergoing liver transplantation have unique challenges with regard to the prevention and management of thrombosis and hemorrhage. Patients with cirrhosis have an unstable balance of the coagulation system due to defects in both prothrombotic and antithrombotic components. These changes make laboratory monitoring challenging, prophylaxis against bleeding and thrombosis controversial, and therapy for the same uncertain. When cirrhotic patients undergo liver transplantation they frequently have significant transfusion requirements...
May 7, 2018: Transplantation
https://www.readbyqxmd.com/read/29757620/separation-of-protactinium-employing-sulfur-based-extraction-chromatographic-resins
#20
Tara Mastren, Benjamin W Stein, T Gannon Parker, Valery Radchenko, Roy Copping, Allison Owens, Lance E Wyant, Mark Brugh, Stosh A Kozimor, F Meiring Nortier, Eva R Birnbaum, Kevin D John, Michael Ernst-Heinrich Fassbender
Protactinium-230 (t1/2 17.4 d) is the parent isotope of 230U (t1/2 20.8 d), a radionuclide of interest for targeted alpha therapy (TAT). Column chromatographic methods have been developed to separate no-carrier-added 230Pa from proton irradiated thorium targets and accompanying fission products. Results reported within demonstrate the use of novel sulfur bearing chromatographic extraction resins for the selective separation of protactinium. The recovery yield of 230Pa was 93 ± 4 % employing a R3P=S type commercially available resin and 88 ± 4 % employing a DGTA (diglycothioamide) containing custom synthesized extraction chromatographic resin...
May 14, 2018: Analytical Chemistry
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