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https://www.readbyqxmd.com/read/28926722/innovation-in-care-for-individuals-with-cognitive-impairment-can-reimbursement-policy-spread-best-practices
#1
Soo Borson, Joshua Chodosh, Cyndy Cordell, Beth Kallmyer, Malaz Boustani, Anna Chodos, Jatin K Dave, Lisa Gwyther, Susan Reed, David B Reuben, Stephen Stabile, Monica Willis-Parker, William Thies
There is now an unprecedented opportunity to improve the care of the over 5 million people who are living with Alzheimer's disease and related dementias and many more with cognitive impairment due to brain injury, systemic diseases, and other causes. The introduction of a new Medicare care planning benefit-long sought openly by advocacy organizations and clinicians and badly needed by patients and families-could greatly improve health care quality, but only if widely and fully implemented. We describe the components of this new benefit and its promise of better clinical care, as well as its potential to create a new platform for clinical and health outcomes research...
September 16, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28926676/randomized-controlled-trial-of-increasing-physical-activity-on-objectively-measured-and-self-reported-cognitive-functioning-among-breast-cancer-survivors-the-memory-motion-study
#2
Sheri J Hartman, Sandahl H Nelson, Emily Myers, Loki Natarajan, Dorothy D Sears, Barton W Palmer, Lauren S Weiner, Barbara A Parker, Ruth E Patterson
BACKGROUND: Increasing physical activity can improve cognition in healthy and cognitively impaired adults; however, the benefits for cancer survivors are unknown. The current study examined a 12-week physical activity intervention, compared with a control condition, on objective and self-reported cognition among breast cancer survivors. METHODS: Sedentary breast cancer survivors were randomized to an exercise arm (n = 43) or a control arm (n = 44). At baseline and at 12 weeks, objective cognition was measured with the National Institutes of Health Cognitive Toolbox, and self-reported cognition using the Patient-Reported Outcomes Measurement Information System scales...
September 19, 2017: Cancer
https://www.readbyqxmd.com/read/28926300/an-updated-scheme-for-categorizing-foods-implicated-in-foodborne-disease-outbreaks-a-tri-agency-collaboration
#3
LaTonia C Richardson, Michael C Bazaco, Cary Chen Parker, Daniel Dewey-Mattia, Neal Golden, Karen Jones, Karl Klontz, Curtis Travis, Joanna Zablotsky Kufel, Dana Cole
BACKGROUND: Foodborne disease data collected during outbreak investigations are used to estimate the percentage of foodborne illnesses attributable to specific food categories. Current food categories do not reflect whether or how the food has been processed and exclude many multiple-ingredient foods. MATERIALS AND METHODS: Representatives from three federal agencies worked collaboratively in the Interagency Food Safety Analytics Collaboration (IFSAC) to develop a hierarchical scheme for categorizing foods implicated in outbreaks, which accounts for the type of processing and provides more specific food categories for regulatory purposes...
September 19, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28925785/risk-adjusted-therapy-in-chronic-lymphocytic-leukemia-a-phase-ii-cancer-trials-ireland-ctrial-ie-icorg-07-01-study-of-fludarabine-cyclophosphamide-and-rituximab-therapy-evaluating-response-adapted-abbreviated-frontline-therapy-with-fcr-in-non-del-17p-cll
#4
Niamh Appleby, David O'Brien, Fiona M Quinn, Liam Smyth, Johanna Kelly, Imelda Parker, Kathleen Scott, Mary R Cahill, Gerard Crotty, Helen Enright, Brian Hennessy, Andrew Hodgson, Maeve Leahy, Hilary O'Leary, Michael O'Dwyer, Amjad Hayat, Elisabeth A Vandenberghe
Minimal residual disease negative complete response (MRD-negative CR) provides an early marker for time to treatment failure (TTF) in CLL treated with fludarabine, cyclophosphamide, and rituximab (FCR). MRD was assessed after four FCR cycles (FCR4); MRD-negative CR patients discontinued treatment. Fifty-two patients (35M; 17F) were enrolled. Eighteen (18/52; 34.6%) patients reached MRD-negative CR after FCR4 and 29/52 (55.8%) were MRD-negative CR at end of treatment (EOT). Median TTF was 71.1 months (95% CI 61...
September 19, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28925732/interleukin-10-gene-transfer-in-rat-limbal-transplantation
#5
Claude Kaufmann, Lauren A Mortimer, Helen M Brereton, Yazad D Irani, Douglas Ga Parker, Donald S Anson, Lucas M Bachmann, Keryn A Williams
PURPOSE: To evaluate the gene transfer of the interleukin (IL)-10 cytokine as a treatment modality for prolonging limbal allograft survival in a rat model. MATERIALS AND METHODS: Adenoviral (AV) and lentiviral (LV) vectors were produced for ex vivo gene transfer into limbal graft tissue prior to orthotopic transplantation. Experimental groups comprised unmodified isografts, unmodified allografts, allografts transfected with a reporter gene, and allografts transfected with IL-10...
September 19, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28924239/the-autophagy-initiator-ulk1-sensitizes-ampk-to-allosteric-drugs
#6
Toby A Dite, Naomi X Y Ling, John W Scott, Ashfaqul Hoque, Sandra Galic, Benjamin L Parker, Kevin R W Ngoei, Christopher G Langendorf, Matthew T O'Brien, Mondira Kundu, Benoit Viollet, Gregory R Steinberg, Kei Sakamoto, Bruce E Kemp, Jonathan S Oakhill
AMP-activated protein kinase (AMPK) is a metabolic stress-sensing enzyme responsible for maintaining cellular energy homeostasis. Activation of AMPK by salicylate and the thienopyridone A-769662 is critically dependent on phosphorylation of Ser108 in the β1 regulatory subunit. Here, we show a possible role for Ser108 phosphorylation in cell cycle regulation and promotion of pro-survival pathways in response to energy stress. We identify the autophagy initiator Unc-51-like kinase 1 (ULK1) as a β1-Ser108 kinase in cells...
September 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28923562/intralesional-injection-of-collagenase-clostridium-histolyticum-may-increase-the-risk-of-late-onset-penile-fracture
#7
REVIEW
Jonathan A Beilan, Jared J Wallen, Adam S Baumgarten, Kevin N Morgan, Justin L Parker, Rafael E Carrion
INTRODUCTION: The use of intralesional injection of collagenase Clostridium histolyticum (CCH) has become a valid treatment option in the management of Peyronie's disease (PD). Multiple studies have shown the drug's safety and efficacy. However, sparse literature exists on the utility of the injection protocol's 14-day "observation period," in which patients are instructed to abstain from all sexual activity. AIM: To summarize the contemporary literature and report on our series of patients treated with CCH in an effort to explore the effectiveness of the postinjection observation period...
September 8, 2017: Sexual Medicine Reviews
https://www.readbyqxmd.com/read/28923140/working-memory-capacity-and-surgical-performance-while-exposed-to-mild-hypoxic-hypoxemia
#8
Paul J Parker, Andrew J Manley, Ross Shand, John P O'Hara, Adrian Mellor
INTRODUCTION: Medical Emergency Response Team (MERT) helicopters fly at altitudes of 3000 m in Afghanistan (9843 ft). Civilian hospitals and disaster-relief surgical teams may have to operate at such altitudes or even higher. Mild hypoxia has been seen to affect the performance of novel tasks at flight levels as low as 5000 ft. Aeromedical teams frequently work in unpressurized environments; it is important to understand the implications of this mild hypoxia and investigate whether supplementary oxygen systems are required for some or all of the team members...
October 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28922695/strategies-for-detecting-colon-cancer-in-patients-with-inflammatory-bowel-disease
#9
REVIEW
William A Bye, Tran M Nguyen, Claire E Parker, Vipul Jairath, James E East
BACKGROUND: Patients with longstanding ulcerative colitis and colonic Crohn's disease have an increased risk of colorectal cancer (CRC) compared with the general population. This review assessed the evidence that endoscopic surveillance may prolong life by allowing earlier detection of CRC or its pre-cursor lesion, dysplasia, in patients with inflammatory bowel disease (IBD). OBJECTIVES: To assess the effectiveness of cancer surveillance programs for diagnosis of IBD-associated colorectal cancer and in reducing the mortality rate from colorectal cancer in patients with IBD...
September 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28922517/effective-relief-of-pain-and-associated-symptoms-with-closed-loop-spinal-cord-stimulation-system-preliminary-results-of-the-avalon-study
#10
Marc Russo, Michael J Cousins, Charles Brooker, Nathan Taylor, Tillman Boesel, Richard Sullivan, Lawrence Poree, Nastaran Hesam Shariati, Erin Hanson, John Parker
OBJECTIVES: Conventional spinal cord stimulation (SCS) delivers a fixed-input of energy into the dorsal column. Physiologic effects such as heartbeat, respiration, spinal cord movement, and history of stimulation can cause both the perceived intensity and recruitment of stimulation to increase or decrease, with clinical consequences. A new SCS system controls stimulation dose by measuring the recruitment of fibers in the dorsal column and by using the amplitude of the evoked compound action potentials (ECAPs) to maintain stimulation within an individualized therapeutic range...
September 18, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/28921967/quantifying-secondary-structure-changes-in-calmodulin-using-2d-ir-spectroscopy
#11
Lucy Minnes, Daniel John Shaw, Benjamin P Cossins, Paul M Donaldson, Gregory M Greetham, Michael Towrie, Anthony Parker, Matthew James Baker, Alistair J Henry, Richard J Taylor, Neil T Hunt
Revealing the details of biomolecular processes in solution needs tools that can monitor structural dynamics over a range of time and length scales. We assess the ability of 2D-IR spectroscopy in combination with multivariate data analysis to quantify changes in secondary structure of the multifunctional calcium-binding messenger protein Calmodulin (CaM) as a function of temperature and Ca2+ concentration. Our approach produced quantitative agreement with circular dichroism (CD) spectroscopy in detecting the domain melting transitions of Ca2+-free (apo) CaM (reduction in α-helix structure by 13% (CD) and 15% (2D))...
September 18, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28921784/the-evolution-of-gonad-expenditure-and-gonadosomatic-index-gsi-in-male-and-female-broadcast-spawning-invertebrates
#12
Geoff A Parker, Steven A Ramm, Jussi Lehtonen, Jonathan M Henshaw
Sedentary broadcast-spawning marine invertebrates, which release both eggs and sperm into the water for fertilization, are of special interest for sexual selection studies. They provide unique insight into the early stages of the evolutionary succession leading to the often-intense operation of both pre- and post-mating sexual selection in mobile gonochorists. Since they are sessile or only weakly mobile, adults can interact only to a limited extent with other adults and with their own fertilized offspring...
September 18, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28920553/where-is-the-nurse-in-nutritional-care
#13
Xiaoyue Xu, Deborah Parker, Caleb Ferguson, Louise Hickman
No abstract text is available yet for this article.
June 2017: Contemporary Nurse
https://www.readbyqxmd.com/read/28919979/reversal-of-fibrosis-in-patients-with-nonalcoholic-steatohepatosis-after-gastric-bypass-surgery
#14
Brian M Parker, Jiang Wu, Jing You, David S Barnes, Lisa Yerian, John P Kirwan, Philip R Schauer, Daniel I Sessler
BACKGROUND: Roux-en-Y gastric bypass (RYGB) improves the pathophysiology that contributes to obesity-related nonalcoholic steatohepatitis (NASH). Whether obesity-related fibrosis improves is unclear. We hypothesized that RYGB reverses NASH and fibrosis, and indocyanine green (ICG) clearance provides a sensitive measure for detecting asymptomatic fatty liver disease. METHODS: One hundred six obese adults scheduled for RYGB had preoperative liver function assessed using standard tests and ICG clearance and core liver biopsies obtained during RYGB...
2017: BMC Obesity
https://www.readbyqxmd.com/read/28919839/ground-up-top-down-a-mixed-method-action-research-study-aimed-at-normalising-research-in-practice-for-nurses-and-midwives
#15
Vicki Parker, Gena Lieschke, Michelle Giles
BACKGROUND: Improving health, patient and system outcomes through a practice-based research agenda requires infrastructural supports, leadership and capacity building approaches, at both the individual and organisational levels. Embedding research as normal nursing and midwifery practice requires a flexible approach that is responsive to the diverse clinical contexts within which care is delivered and the variable research skills and interest of clinicians. This paper reports the study protocol for research being undertaken in a Local Health District (LHD) in New South Wales (NSW) Australia...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28919180/development-of-a-cyclosporin-a-derivative-with-excellent-anti-hepatitis-c-virus-potency
#16
Jiping Fu, Christopher Becker, Li Cao, Michael Capparelli, Regis Denay, Roger Fujimoto, Yu Gai, Zhaobo Gao, Christian Guenat, Subramanian Karur, Hongyong Kim, Weikuan Li, Xiaolin Li, Wei Li, Thomas Lochmann, Amy Lu, Peichao Lu, Alexandre Luneau, Nicole Meier, Wosenu Mergo, Simon Ng, David Parker, Yunshan Peng, Bernard Riss, Alexey Rivkin, Silvio Roggo, Harald Schroeder, Friedrich Schuerch, Robert L Simmons, Feng Sun, Zachary K Sweeney, Meiliana Tjandra, Michael Wang, Ruidong Wang, Andrew H Weiss, Nicolas Wenger, Quanbing Wu, Xin Xiong, Su Xu, Wenjian Xu, Aregahegn Yifru, Jibin Zhao, Jianguang Zhou, Christian Zürcher, Fabrice Gallou
Synthetic modification of cyclosporin A at P3-P4 positions led to the discovery of NIM258, a next generation cyclophilin inhibitor with excellent anti-hepatitis C virus potency, with decreased transporter inhibition, and pharmacokinetics suitable for coadministration with other drugs. Herein is disclosed the evolution of the synthetic strategy to from the original medicinal chemistry route, designed for late diversification, to a convergent and robust development synthesis. The chiral centers in the P4 fragment were constructed by an asymmetric chelated Claisen rearrangement in the presence of quinidine as the chiral ligand...
September 7, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28918874/the-outcome-of-intracapsular-hip-fracture-fixation-using-the-targon-femoral-neck-tfn-locking-plate-system-or-cannulated-cancellous-screws-a-comparative-study-involving-2004-patients
#17
Zeiad Alshameeri, Mohamed Elbashir, Martyn J Parker
AIM: This study compares the outcome of intracapsular hip fracture fixation using the Targon Femoral Neck (TFN) locking plate system with the standard fixation using cannulated cancellous screws (CCS). PATIENTS AND METHOD: Analyses of a prospectively collected data of all patients treated for intracapsular hip fractures using the TFN system and CCS at our department over a period of 28 years. Baseline characteristics and specific outcome measures where compared...
September 1, 2017: Injury
https://www.readbyqxmd.com/read/28918732/acupuncture-for-analgesia-in-the-emergency-department-a-multicentre-randomised-equivalence-and-non-inferiority-trial
#18
Marc M Cohen, De Villiers Smit, Nick Andrianopoulos, Michael Ben-Meir, David McD Taylor, Shefton J Parker, Chalie C Xue, Peter A Cameron
OBJECTIVES: This study aimed to assess analgesia provided by acupuncture, alone or in combination with pharmacotherapy, to patients presenting to emergency departments with acute low back pain, migraine or ankle sprain. DESIGN: A pragmatic, multicentre, randomised, assessor-blinded, equivalence and non-inferiority trial of analgesia, comparing acupuncture alone, acupuncture plus pharmacotherapy, and pharmacotherapy alone for alleviating pain in the emergency department...
June 19, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28918726/a-day-in-the-life-social-media-for-clinical-practice-and-medical-education
#19
Victoria Brazil, Casey Parker
No abstract text is available yet for this article.
June 19, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28918424/systemic-inflammatory-response-is-a-prognostic-marker-in-hiv-infected-patients-with-hepatocellular-carcinoma
#20
David J Pinato, Marco Merli, Alessia Dalla Pria, Shiraz Jamshaid, Kizzy Parker, Nicole Pagani, Hamid Hasson, Caterina Uberti Foppa, Emanuela Messina, Rohini Sharma, Mark Nelson, Mark Bower
BACKGROUND: Hepatocellular carcinoma (HCC) is increasingly prevalent in people living with HIV. Systemic inflammation is a prognostic factor requiring validation in HIV-associated HCC. AIMS: Using a multi-centre database of consecutive HCC cases, we investigated the prognostic role of a panel of inflammatory markers, including neutrophil to lymphocyte ratio (NLR), using univariate and multivariate survival analyses. RESULTS: Fifty-nine patients with HIV-associated HCC secondary to hepatitis C (69%) or B virus infection (32%) were identified...
September 16, 2017: Oncology
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