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https://www.readbyqxmd.com/read/29655396/are-lateral-ankle-injuries-in-children-fractures-or-sprains
#1
Erica Beatty, Maude Deschênes, Patrick Archambault
Clinical questionWhat is the prevalence of Salter-Harris type I distal fibula fractures in children with lateral ankle injuries?Article chosenBoutis K, Plint A, Stimec J, et al. Radiograph-negative lateral ankle injuries in children occult growth plate fracture or sprain? JAMA Pediatr 2016;170(1):e154114.
April 15, 2018: CJEM
https://www.readbyqxmd.com/read/29644319/traumatic-pediatric-shoulder-fracture-dislocation-treated-with-closed-reduction-and-intramedullary-nailing-a-case-report
#2
Ghazi Fannouch, Yasser I Al Khalife, Abdulaziz S Al Turki, Ayman H Jawadi
Background: Although rare, pediatric proximal humerus fractures may coexist with glenohumeral dislocations. Most of these injuries are Salter -Harris type of injuries. The treatment usually consists of closed or open reduction and k- wires fixation. The case: In this case report; a 10-year-old girl presented with a rare traumatic humeral surgical neck fracture with a posterior shoulder dislocation that was treated by closed reduction and flexible intramedullary nailing...
June 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29624080/supporting-the-sexual-rights-of-women-living-with-hiv-a-critical-analysis-of-sexual-satisfaction-and-pleasure-across-five-relationship-types
#3
Allison Carter, Saara Greene, Deborah Money, Margarite Sanchez, Kath Webster, Valerie Nicholson, Lori A Brotto, Catherine Hankins, Mary Kestler, Neora Pick, Kate Salters, Karène Proulx-Boucher, Nadia O'Brien, Sophie Patterson, Alexandra de Pokomandy, Mona Loutfy, Angela Kaida
In the context of human immunodeficiency virus (HIV), a focus on protecting others has overridden concern about women's own sexual well-being. Drawing on feminist theories, we measured sexual satisfaction and pleasure across five relationship types among women living with HIV in Canada. Of the 1,230 women surveyed, 38.1% were completely or very satisfied with their sexual lives, while 31.0% and 30.9% were reasonably or not very/not at all satisfied, respectively. Among those reporting recent sexual experiences (n = 675), 41...
April 6, 2018: Journal of Sex Research
https://www.readbyqxmd.com/read/29614089/hippocampal-protein-kinase-d1-is-necessary-for-dhpg-induced-learning-and-memory-impairments-in-rats
#4
Wei Wang, Florian Duclot, Bradley R Groveman, Nicole Carrier, Haifa Qiao, Xiao-Qian Fang, Hui Wang, Wenkuan Xin, Xing-Hong Jiang, Michael W Salter, Xin-Sheng Ding, Mohamed Kabbaj, Xian-Min Yu
BACKGROUND: Understanding molecular mechanisms underlying the induction of learning and memory impairments remains a challenge. Recent investigations have shown that the activation of group I mGluRs (mGluR1 and mGluR5) in cultured hippocampal neurons by application of (S)-3,5-Dihydroxyphenylglycine (DHPG) causes the regulated internalization of N-methyl-D-aspartate receptors (NMDARs), which subsequently activates protein kinase D1 (PKD1). Through phosphorylating the C-terminals of the NMDAR GluN2 subunits, PKD1 down-regulates the activity of remaining (non-internalized) surface NMDARs...
2018: PloS One
https://www.readbyqxmd.com/read/29609878/a-new-class-of-antiretroviral-enabling-innate-immunity-by-protecting-apobec3-from-hiv-vif-dependent-degradation
#5
REVIEW
Ryan P Bennett, Jason D Salter, Harold C Smith
The infectivity of HIV depends on overcoming APOBEC3 (A3) innate immunity, predominantly through the expression of the viral protein Vif, which induces A3 degradation in the proteasome. Disruption of the functional interactions of Vif enables A3 mutagenesis of the HIV genome during viral replication, which can result in a broadly neutralizing antiviral effect. Vif function requires self-association along with interactions with A3 proteins, protein chaperones, and factors of the ubiquitination machinery and these are described here as a potential platform for novel antiviral drug discovery...
March 30, 2018: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/29582019/truncating-slc5a7-mutations-underlie-a-spectrum-of-dominant-hereditary-motor-neuropathies
#6
Claire G Salter, Danique Beijer, Holly Hardy, Katy E S Barwick, Matthew Bower, Ines Mademan, Peter De Jonghe, Tine Deconinck, Mark A Russell, Meriel M McEntagart, Barry A Chioza, Randy D Blakely, John K Chilton, Jan De Bleecker, Jonathan Baets, Emma L Baple, David Walk, Andrew H Crosby
Objective: To identify the genetic cause of disease in 2 previously unreported families with forms of distal hereditary motor neuropathies (dHMNs). Methods: The first family comprises individuals affected by dHMN type V, which lacks the cardinal clinical feature of vocal cord paralysis characteristic of dHMN-VII observed in the second family. Next-generation sequencing was performed on the proband of each family. Variants were annotated and filtered, initially focusing on genes associated with neuropathy...
April 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/29561460/spinal-dysraphism-and-dislocated-hip-beware-of-anomalous-sciatic-nerve-through-ilium-a-case-report
#7
Amanda T Whitaker, James Kasser, Young-Jo Kim
RATIONALE: The sciatic nerve runs a predictable course combining L4-S3 nerve roots through the true pelvis and under the greater sciatic notch. There are reports of bony protuberances from the sacrum and ilium in cases of spinal dysraphism; however advanced imaging, treatment, or outcomes are not described. There are no cases with associated fibular hemimelia in the current literature. PATIENT CONCERNS: This is a 4-year-old girl with tethered cord, acetabular dysplasia with hip subluxation, congenital short femur, anterior cruciate ligament (ACL) deficiency, and fibular hemimelia with her sciatic nerve coursing through the ilium...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29559840/dexamethasone-down-regulates-osteocalcin-in-bone-cells-through-leptin-pathway
#8
Shu-Mei Chen, Yi-Jen Peng, Chih-Chien Wang, Sui-Lung Su, Donald M Salter, Herng-Sheng Lee
Glucocorticoid therapy, especially at higher doses, is associated with significant adverse side effects including osteoporosis. Leptin, secreted from adipose tissue, has diverse effects on bone tissue regulation. As glucocorticoids stimulate leptin synthesis and secretion directly in adipose tissue we hypothesised that dexamethasone (DEX) induced osteoporosis may, in part, be mediated by an osteoblast dependent leptin-leptin receptor pathway. Human bone cells expressed leptin and leptin receptors (Ob-Ra and Ob-Rb)...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29558292/synergy-of-sex-differences-in-visceral-fat-measured-with-ct-and-tumor-metabolism-helps-predict-overall-survival-in-patients-with-renal-cell-carcinoma
#9
Gerard K Nguyen, Vincent M Mellnick, Aldrin Kay-Yuen Yim, Amber Salter, Joseph E Ippolito
Purpose To determine if sex differences in abdominal visceral fat composition, measured by using computed tomography (CT), and tumor glucose metabolism, measured by gene expression, can help predict outcomes in patients with clear cell renal cell carcinoma (RCC). Materials and Methods This retrospective cohort study included 222 patients with clear cell RCC from The Cancer Imaging Atlas. By using CT, body fat was segmented into subcutaneous fat and visceral fat areas (VFAs) and normalized to total fat to obtain the relative VFA (rVFA) and relative subcutaneous fat area...
March 20, 2018: Radiology
https://www.readbyqxmd.com/read/29555137/when-a-private-community-neurology-practice-executes-home-sleep-apnea-testing-benefits-identified-and-lessons-learned-in-a-retrospective-observational-study
#10
Charlene E Gamaldo, Alyssa A Gamaldo, Laurence T Hou, Aadi Kalloo, Daniel Hexter, Brian Salter, Molly Price, Maya Carter, Rachel Marie E Salas
OBJECTIVE: To investigate the feasibility and utility of a private community neurology practice-initiated home sleep apnea testing (HSAT) program. METHODS: A private community neurology practice conducted HSAT on patients clinically identified as high risk for obstructive sleep apnea (OSA). An academic board-certified sleep specialist performed all study interpretations. The presence and severity of OSA and its association with patient demographics (eg, sex, age) and comorbid health conditions relevant to OSA were evaluated...
April 2018: Sleep Health
https://www.readbyqxmd.com/read/29535113/elevated-platelet-counts-in-a-cohort-of-children-with-moderate-severe-osteogenesis-imperfecta-suggest-that-inflammation-is-present
#11
Lois Salter, Amaka C Offiah, Nicholas Bishop
BACKGROUND: Elevated platelet counts are observed in cancer, autoimmunity and inflammation with concurrent illness. Proinflammatory cytokines are elevated in murine osteogenesis imperfecta (OI) models. We hypothesised that platelet counts might be elevated in children with moderate-severe OI. METHODS: We reviewed the hospital records of 71 children with moderate-severe OI, treated in the Sheffield Children's Hospital's Severe, Complex and Atypical Osteogenesis Imperfecta Highly Specialised Service...
March 13, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29517284/thermal-ablation-versus-surgical-resection-for-localized-hepatocellular-carcinoma-a-population-study-using-the-seer-database
#12
Abigail Mills, David Thayer, Christopher Noda, Amber Salter, Yu Tao, Minzhi Xing, Robert Martin, Raja Ramaswamy, Olaguoke Akinwande
AIM: To compare overall survival (OS) and liver cancer-specific survival (LCSS) in patients with localized hepatocellular carcinoma treated with surgical resection (SR) or thermal ablation (TA) using the Surveillance, Epidemiology and End Results database. MATERIALS & METHODS: Kaplan-Meier, competing risk and Cox regression analyses were performed after identifying patients. Propensity score matching was then applied. RESULTS: There was significantly better OS in the SR group and significantly lower probability of LCSS in the TA group...
March 2018: Future Oncology
https://www.readbyqxmd.com/read/29510324/a-survey-of-dietary-characteristics-in-a-large-population-of-people-with-multiple-sclerosis
#13
Kathryn C Fitzgerald, Tuula Tyry, Amber Salter, Stacey S Cofield, Gary Cutter, Robert J Fox, Ruth Ann Marrie
INTRODUCTION: Dietary approaches to management of MS has been proposed for several decades, yet very little is known concerning dietary composition or adherence to specialized diets in people with multiple sclerosis (MS). METHODS: We conducted a survey of participants in the North American Research Committee on MS (NARCOMS) registry assessing diet composition and the prevalence of 19 different diets. We characterized prevalence of different diets and compared diet composition with estimated intakes from the National Health and Nutrition Examination Survey (NHANES) survey respondents and across demographics and MS clinical characteristics...
February 27, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29504171/evaluation-of-noncontrast-mr-enterography-for-pediatric-inflammatory-bowel-disease-assessment
#14
Michael Hunter Lanier, Anup S Shetty, Amber Salter, Geetika Khanna
BACKGROUND: Gadolinium deposition in normal tissues is being increasingly recognized. Children with inflammatory bowel disease (IBD) undergo frequent imaging with contrast-enhanced MR enterography (MRE). PURPOSE: To determine the impact of intravenous (IV) gadolinium in assessment of pediatric IBD by MRE. STUDY TYPE: Retrospective, case series. POPULATION: Radiology information system was searched to identify all children who underwent MRE and endoscopy within 30 days in 2016...
March 5, 2018: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29485016/comparing-the-bioburden-measured-by-adenosine-triphosphate-atp-luminescence-technology-to-contact-plate-based-microbiologic-sampling-to-assess-the-cleanliness-of-the-patient-care-environment
#15
Elizabeth Salsgiver, Daniel Bernstein, Matthew S Simon, William Greendyke, Haomiao Jia, Amy Robertson, Selma Salter, Audrey N Schuetz, Lisa Saiman, E Yoko Furuya, David P Calfee
The correlation between ATP concentration and bacterial burden in the patient care environment was assessed. These findings suggest that a correlation exists between ATP concentration and bacterial burden, and they generally support ATP technology manufacturer-recommended cutoff values. Despite relatively modest discriminative ability, this technology may serve as a useful proxy for cleanliness. Infect Control Hosp Epidemiol 2018;1-3.
February 27, 2018: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29484463/medial-humeral-condyle-fracture-in-childhood-a-rare-but-often-overlooked-injury
#16
F F Fernandez, S Vatlach, T Wirth, O Eberhardt
The medial condyle fracture of the humerus is-in comparison to the lateral condyle fracture-a very rare Salter-Harrison IV-fracture of the elbow. In this prospective study 14 children were included and reviewed. One child had minimal displacement fracture type I, one child had type II, and 12 children had type III-fractures. One patient was treated conservatively by an upper arm cast; thirteen were surgically treated using open reduction and osteosynthetical treatment. Postoperatively the elbow was immobilized in 90° flexion and neutral position in a long-arm cast for 4-6 weeks...
February 26, 2018: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/29477021/factors-associated-with-excessive-sitting-time-in-multiple-sclerosis
#17
Jeffer E Sasaki, Robert W Motl, Gary Cutter, Ruth Ann Marrie, Tuula Tyry, Amber Salter
OBJECTIVE: The objective of this study was to examine the sociodemographic, clinical, and behavioral factors associated with excessive sitting time in persons with multiple sclerosis (MS). METHODS: Useful data were obtained from 6483 persons with MS who completed the semi-annual survey of the North American Research Committee on Multiple Sclerosis registry conducted in the spring of 2015. Sociodemographic, clinical, and behavioral data were collected using self-report questionnaires...
February 10, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29474423/seasonal-variability-in-the-persistence-of-dissolved-environmental-dna-edna-in-a-marine-system-the-role-of-microbial-nutrient-limitation
#18
Ian Salter
Environmental DNA (eDNA) can be defined as the DNA pool recovered from an environmental sample that includes both extracellular and intracellular DNA. There has been a significant increase in the number of recent studies that have demonstrated the possibility to detect macroorganisms using eDNA. Despite the enormous potential of eDNA to serve as a biomonitoring and conservation tool in aquatic systems, there remain some important limitations concerning its application. One significant factor is the variable persistence of eDNA over natural environmental gradients, which imposes a critical constraint on the temporal and spatial scales of species detection...
2018: PloS One
https://www.readbyqxmd.com/read/29456832/interleukin-25-and-eosinophils-progenitor-cell-mobilization-in-allergic-asthma
#19
Wei Tang, Steven G Smith, Wei Du, Akash Gugilla, Juan Du, John Paul Oliveria, Karen Howie, Brittany M Salter, Gail M Gauvreau, Paul M O'Byrne, Roma Sehmi
Background: Eosinophil-lineage committed progenitor cells (EoP) migrate from the bone marrow and differentiate locally to provide an ongoing source of mature eosinophils in asthmatic inflammatory responses in the airways. Sputum levels of EoP are increased in asthmatics compared to normal controls suggesting an exaggerated eosinophilopoietic environment in the airways. Understanding what factors promote EoP traffic to the airways is important to understand the diathesis of asthma pathology...
2018: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/29454563/radiological-and-clinical-outcomes-of-medial-approach-open-reduction-by-using-two-intervals-in-developmental-dysplasia-of-the-hip
#20
Afsar T Ozkut, Yusuf Iyetin, Omer K Unal, M Salih Soylemez, Esat Uygur, Irfan Esenkaya
OBJECTIVE: To evaluate the midterm clinical and radiological outcomes of the medial approach using two intervals for developmental hip dysplasia (DDH). METHODS: The study involved 62 hips of 47 patients (41 girls, 6 boys) treated with medial approach for DDH from 1999 to 2010. The age of the patients at surgery was 18.7 ± 2.25 months. Follow up of the patients was 11.3 ± 3.07 years. The age of the patients at the last follow up was 12.6 ± 1.74 years. According to the Tönnis classification, 13 hips were grade II, 27 hips were grade III and 22 hips were grade IV...
February 14, 2018: Acta Orthopaedica et Traumatologica Turcica
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