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https://www.readbyqxmd.com/read/29039128/distal-femoral-flexion-deformity-from-growth-disturbance-treated-with-a-two-level-osteotomy-and-internal-lengthening-nail
#1
Austin T Fragomen, Fiona R Fragomen
Salter Harris fractures of the distal femur can lead to growth disturbance with resulting leg length inequality and knee deformity. We have looked at a case series (3) of patients who presented with a distal femur flexion malunion and shortening treated with a distal femoral osteotomy and plating and a proximal femoral osteotomy with a magnetic internal lengthening nail. Does a two-level osteotomy and internal fixation approach provide a reliable result both radiographically and functionally? The average knee extension loss was 12°, LLD 47 mm, PDFA 65°, MAD 2 mm...
October 16, 2017: Strategies in Trauma and Limb Reconstruction
https://www.readbyqxmd.com/read/29033612/increased-detection-of-precancerous-cervical-lesions-with-adjunctive-dynamic-spectral-imaging
#2
Sara A DeNardis, Philip T Lavin, Jeff Livingston, William R Salter, Nanette James-Patrick, Emmanouil Papagiannakis, Christopher G Olson, Lori Weinberg
OBJECTIVE: To validate, in US community-based colposcopy clinics, previous reports of increased detection of high-grade cervical intraepithelial neoplasia (CIN2+) with biopsies selected using dynamic spectral imaging (DSI) mapping after standard colposcopy. STUDY DESIGN: Cross-sectional observational study of 26 colposcopists across nine clinics recruiting consecutive colposcopy patients. Standard assessment with biopsy selections was completed before seeing the DSI map which was subsequently interpreted and used for additional biopsies per clinical judgment...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/29027185/advanced-containment-methods-for-legg-calv%C3%A3-perthes-disease-triple-pelvic-osteotomy-versus-chiari-osteotomy
#3
Olivier Rosello, Federico Solla, Ioana Oborocianu, Edouard Chau, Tony ElHayek, Jean-Luc Clement, Virginie Rampal
INTRODUCTION: The goal of intervention in Legg-Calvé-Perthes disease (LCPD) is to prevent femoral head deformation by containing the head within the acetabulum. Currently, surgical containment methods are the mainstay of treatment, and pelvic osteotomies have been shown to be successful. They include triple pelvic osteotomy (TPO), Salter osteotomy, Chiari osteotomy and shelf procedure. The purpose of this study was to compare clinical and radiologic results for Chiari osteotomy and TPO in LCPD...
October 11, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29025614/outcome-of-distal-tibia-physeal-fractures-a-review-of-cases-as-related-to-risk-factors
#4
Fabio D'Angelo, Giuseppe Solarino, Davide Tanas, Alessia Zani, Paolo Cherubino, Biagio Moretti
INTRODUCTION: The physeal fractures represent the 20-30% of all fractures of the child. The distal tibial physis is the third most frequently injured. The most important complication is the premature physeal closure (PPC). Aim of this study is to evaluate risk factors that can influence the outcome like fracture pattern, fracture displacement, mechanism of injury and treatment method. MATERIAL AND METHODS: The records of 46 patients treated for distal tibia physeal fractures between 2003 and 2013 were reviewed...
October 2017: Injury
https://www.readbyqxmd.com/read/29024046/traumatic-brain-injury-in-the-prodromal-period-of-parkinson-disease-a-large-epidemiological-study-using-medicare-data
#5
Alejandra Camacho-Soto, Mark N Warden, Susan Searles Nielsen, Amber Salter, David L Brody, Heidi Prather, Brad A Racette
OBJECTIVE: Studies suggest a greater risk of Parkinson disease (PD) after traumatic brain injury (TBI), but it is possible that the risk of TBI is greater in the prodromal period of PD. We aimed to examine the time-to-TBI in PD patients in their prodromal period compared to population-based controls. METHODS: We identified 89,790 incident PD cases and 118,095 comparable controls > 65 years of age in 2009 using Medicare claims data. Using data from the preceding five years, we compared time-to-TBI in PD patients in their prodromal period to controls...
October 10, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29023275/proximal-radial-head-fractures-in-young-gymnasts-a-case-series-of-newly-described-overuse-injuries
#6
Jaron Santelli, Teri M McCambridge, Amy E Valasek, Kathleen Standiford
We report a case series of unilateral Salter-Harris IV fractures of the proximal radial heads in young female gymnasts. To date, there are no previous reports of such injuries in gymnastics. In all 3 athletes, no significant injury preceded presentation or diagnosis. Radiographs and magnetic resonance imaging showed fractures and associated bone marrow edema of the proximal radial head, respectively. All but 1 was treated nonoperatively with success. Given the lack of acute trauma, lack of large effusion, and good range of motion at presentation, these injuries are believed to be chronic in nature and related to overuse...
October 11, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29019753/imaging-of-pediatric-growth-plate-disturbances
#7
Jie C Nguyen, B Keegan Markhardt, Arnold C Merrow, Jerry R Dwek
The growth plates, or physes, are visible on virtually all images obtained in skeletally immature children. The proper function of these growth plates depends on an intricate balance between chondrocyte proliferation, which requires nourishment from the epiphyseal vessels, and chondrocyte death, which requires the integrity of the metaphyseal vessels. Therefore, injury to the growth plate (ie, direct insult) or vascular compromise on either side of the growth plate (ie, indirect insult) can cause growth plate dysfunction...
October 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28990190/a-randomized-waitlist-control-community-study-of-social-cognition-and-interaction-training-for-people-with-schizophrenia
#8
Anne Gordon, Penelope J Davis, Susan Patterson, Christopher A Pepping, James G Scott, Kerri Salter, Melissa Connell
OBJECTIVE: Social Cognition and Interaction Training (SCIT) has demonstrated effectiveness in improving social cognition and functioning of people with schizophrenia. This pilot study examines the acceptability, feasibility, and effectiveness of SCIT with individuals who have schizophrenia-spectrum disorders and are receiving care through a public mental health service. METHOD: In a pragmatic randomized waitlist controlled trial, 36 participants (aged 19-55 years) with a schizophrenia spectrum disorder were randomly allocated to SCIT or treatment as usual (TAU)...
October 9, 2017: British Journal of Clinical Psychology
https://www.readbyqxmd.com/read/28984686/intraobserver-and-interobserver-reliability-of-radiographic-analysis-of-proximal-humerus-fractures-in-adolescents
#9
Michelle C Burke, Christopher Minnock, Christopher B Robbins, Matthew D Abbott, Michelle S Caird, Frances A Farley, Jacob Kirsch, Jared Thomas, Ying Li
BACKGROUND: Multiple studies have shown low intrarater and interrater agreement of radiographic classification systems for proximal humerus fractures (PHFs) in adults. There is no standardized method of measuring angulation of pediatric PHFs, nor is there consensus as to the amount of angulation and displacement that require operative fixation of adolescent PHFs. We propose a new standardized method to measure fracture angulation that is similar to the method used to measure the epiphyseal-shaft angle for slipped capital femoral epiphysis...
October 3, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28984680/pan-tibial-avascular-necrosis-in-a-12-year-old-boy-a-case-report
#10
Nirmal R Gopinathan, Balaji Saibaba, Siva S Santhanam, Kevin Syam
We report a unique case of post-traumatic avascular necrosis of tibia in a 12-year-old boy following a Salter-Harris type II physeal injury of the proximal tibia. The diagnosis was made on the basis of classical radiological findings. The only clinical symptom was diffuse shin pain. The patient was managed conservatively. At our 2-year follow-up, there was clinical and radiological evidence of spontaneous resolution of avascular necrosis, but with sequelae. The child developed a limb-length discrepancy and genu valgum...
October 3, 2017: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/28968382/a-longitudinal-study-of-the-infant-nasopharyngeal-microbiota-the-effects-of-age-illness-and-antibiotic-use-in-a-cohort-of-south-east-asian-children
#11
Susannah J Salter, Claudia Turner, Wanitda Watthanaworawit, Marcus C de Goffau, Josef Wagner, Julian Parkhill, Stephen D Bentley, David Goldblatt, Francois Nosten, Paul Turner
A longitudinal study was undertaken in infants living in the Maela refugee camp on the Thailand-Myanmar border between 2007 and 2010. Nasopharyngeal swabs were collected monthly, from birth to 24 months of age, with additional swabs taken if the infant was diagnosed with pneumonia according to WHO clinical criteria. At the time of collection, swabs were cultured for Streptococcus pneumoniae and multiple serotype carriage was assessed. The bacterial 16S rRNA gene profiles of 544 swabs from 21 infants were analysed to see how the microbiota changes with age, respiratory infection, antibiotic consumption and pneumococcal acquisition...
October 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28958578/efficient-targeting-and-activation-of-antigen-presenting-cells-in%C3%A2-vivo-after-modified-mrna-vaccine-administration-in-rhesus-macaques
#12
Frank Liang, Gustaf Lindgren, Ang Lin, Elizabeth A Thompson, Sebastian Ols, Josefine Röhss, Shinu John, Kimberly Hassett, Olga Yuzhakov, Kapil Bahl, Luis A Brito, Hugh Salter, Giuseppe Ciaramella, Karin Loré
mRNA vaccines are rapidly emerging as a powerful platform for infectious diseases because they are well tolerated, immunogenic, and scalable and are built on precise but adaptable antigen design. We show that two immunizations of modified non-replicating mRNA encoding influenza H10 hemagglutinin (HA) and encapsulated in lipid nanoparticles (LNP) induce protective HA inhibition titers and H10-specific CD4(+) T cell responses after intramuscular or intradermal delivery in rhesus macaques. Administration of LNP/mRNA induced rapid and local infiltration of neutrophils, monocytes, and dendritic cells (DCs) to the site of administration and the draining lymph nodes (LNs)...
August 12, 2017: Molecular Therapy: the Journal of the American Society of Gene Therapy
https://www.readbyqxmd.com/read/28957060/femtosecond-laser-inscription-of-bragg-grating-waveguides-in-bulk-diamond
#13
V Bharadwaj, A Courvoisier, T T Fernandez, R Ramponi, G Galzerano, J Nunn, M J Booth, R Osellame, S M Eaton, P S Salter
Femtosecond laser writing is applied to form Bragg grating waveguides in the diamond bulk. Type II waveguides are integrated with a single pulse point-by-point periodic laser modification positioned toward the edge of the waveguide core. These photonic devices, operating in the telecommunications band, allow for simultaneous optical waveguiding and narrowband reflection from a fourth-order grating. This fabrication technology opens the way toward advanced 3D photonic networks in diamond for a range of applications...
September 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28947584/author-response-high-hypothetical-interest-in-physician-assisted-death-in-multiple-sclerosis
#14
Ruth Ann Marrie, Amber Salter, Tuula Tyry, Gary R Cutter, Robert J Fox
No abstract text is available yet for this article.
September 26, 2017: Neurology
https://www.readbyqxmd.com/read/28941639/the-role-of-the-immune-system-in-alzheimer-disease-etiology-and-treatment
#15
REVIEW
Stefan Jevtic, Ameet S Sengar, Michael W Salter, JoAnne McLaurin
The immune system is now considered a major factor in Alzheimer Disease (AD). This review seeks to demonstrate how various aspects of the immune system, both in the brain and peripherally, interact to contribute to AD. We highlight classical nervous system immune components, such as complement and microglia, as well as novel aspects of the peripheral immune system that can influence disease, such as monocytes and lymphocytes. By detailing the roles of various immune cells in AD, we summarize an emerging perspective for disease etiology and future therapeutic targets...
September 21, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28930867/pancreatic-neuroendocrine-tumors-computed-tomography-enhancement-but-not-histological-grade-correlates-with-tumor-aggression
#16
Motoyo Yano, Sunil Misra, Danielle H Carpenter, Amber Salter, Charles F Hildebolt
OBJECTIVES: The aims of this study were to assess computed tomography enhancement of pancreatic neuroendocrine tumors (NETs), determine correlation with histological vascularity and fibrosis, and identify a biomarker for tumor aggression. METHODS: The arterial and venous enhancement of NET was calculated on computed tomography for 56 patients. Tumor size and vascularity/fibrosis were assessed. Tumor aggression was grouped by World Health Organization and Hochwald grade and the presence of metastases...
November 2017: Pancreas
https://www.readbyqxmd.com/read/28928921/an-unusual-cause-of-genu-valgum-and-persistent-instability
#17
Edward Holloway, Paul Sutton, Robert Cooper
We present the case of a professional adolescent footballer who attended our clinic with ongoing instability symptoms and valgus knee deformity after conservative management of an medial collateral ligament injury. The patient was found to have sustained a contra-coup Salter Harris Type V injury to his lateral distal femur physis resulting in premature growth arrest and deformity. Salter Harris Type V injuries are rare, and often not diagnosed until growth has arrest has occurred due to lack of identifiable features on initial plain radiographs...
August 2017: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/28928514/component-analysis-of-nutritionally-rich-chloroplasts-recovery-from-conventional-and-unconventional-green-plant-species
#18
Mohamed A Gedi, Rhianna Briars, Felius Yuseli, Noorazwani Zainol, Randa Darwish, Andrew M Salter, David A Gray
A study of the literature indicates that chloroplasts synthesise a range of molecules, many of which have nutritional value for humans, but the nutritional credentials of chloroplasts recovered from plant cells are not established. Chloroplast-rich-fractions (CRFs) were prepared from green plant species and the macro- and micro-nutrient composition compared with the whole leaf materials (WLMs). The results indicated that, on a dry weight basis, CRF material from a range of green biomass was enriched in lipids and proteins, and in a range of micronutrients compared with the WLM...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28927786/discovery-of-highly-potent-selective-covalent-inhibitors-of-jak3
#19
James Kempson, Damaso Ovalle, Junqing Guo, Stephen T Wrobleski, Shuqun Lin, Steven H Spergel, James J-W Duan, Bin Jiang, Zhonghui Lu, Jagabandhu Das, Bingwei V Yang, John Hynes, Hong Wu, John Tokarski, John S Sack, Javed Khan, Gary Schieven, Yuval Blatt, Charu Chaudhry, Luisa M Salter-Cid, Aberra Fura, Joel C Barrish, Percy H Carter, William J Pitts
A useful and novel set of tool molecules have been identified which bind irreversibly to the JAK3 active site cysteine residue. The design was based on crystal structure information and a comparative study of several electrophilic warheads.
September 11, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28925312/what-is-the-best-treatment-for-displaced-salter-harris-ii-physeal-fractures-of-the-distal-tibia
#20
Hoon Park, Dong Hoon Lee, Seung Hwan Han, Sungmin Kim, Nam Kyu Eom, Hyun Woo Kim
Background and purpose - The optimal treatment of displaced Salter-Harris (SH) II fractures of the distal tibia is controversial. We compared the outcomes of operative and nonoperative treatment of SH II distal tibial fractures with residual gap of >3 mm. Factors that may be associated with the incidence of premature physeal closure (PPC) were analyzed. Patients and methods - We retrospectively reviewed 95 patients who were treated for SH II distal tibial fractures with residual gap of >3 mm after closed reduction...
September 19, 2017: Acta Orthopaedica
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