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https://www.readbyqxmd.com/read/28214061/open-physeal-fracture-of-the-distal-phalanx-of-the-hallux-case-study-diagnosis-and-management
#1
Brandon Morris, Scott Mullen, Paul Schroeppel, Bryan Vopat
Open physeal fractures of the distal phalanx of the hallux are the lesser described counterpart to the same fracture of the finger, known by its eponym as a "Seymour fracture". Displaced Salter-Harris phalangeal fractures present with a concomitant nailbed or soft tissue injury. Often these fractures occur in the summer months when open-toe footwear can be worn, however, they may occur indoors as well. Frequently, the injury results from direct axial load of the toe, or "stubbing", which causes the fracture and associated soft tissue injury...
February 6, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28213181/allergic-asthmatic-subjects-have-elevated-levels-of-ige-b-cells-in-the-airways
#2
John-Paul Oliveria, Brittany M Salter, Stephanie Phan, Caitlin D Obminski, Caroline E Munoz, Steven G Smith, Tara X Scime, Richard M Watson, Roma Sehmi, Gail M Gauvreau
No abstract text is available yet for this article.
February 14, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28206647/fasiglifam-tak-875-mechanistic-investigation-and-retrospective-identification-of-hazards-for-drug-induced-liver-injury-dili
#3
Monicah A Otieno, Jan Snoeys, Wing Lam, Avi Ghosh, Mark R Player, Alessandro Pocai, Rhys Salter, Damir Simic, Hollie Skaggs, Bhanu Singh, Lim Heng-Keang
No abstract text is available yet for this article.
February 16, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28202953/fully-human-cd19-specific-chimeric-antigen-receptors-for-t-cell-therapy
#4
D Sommermeyer, T Hill, S M Shamah, A I Salter, Y Chen, K M Mohler, S R Riddell
Impressive results have been achieved by adoptively transferring T-cells expressing CD19-specific CARs with binding domains from murine mAbs to treat B-cell malignancies. T-cell mediated immune responses specific for peptides from the murine scFv antigen-binding domain of the CAR can develop in patients and result in premature elimination of CAR-T-cells increasing the risk of tumor relapse. As fully human scFv might reduce immunogenicity, we generated CD19-specific human scFvs with similar binding characteristics as the murine FMC63-derived scFv using human Ab/DNA-libraries...
February 16, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28199046/bone-regeneration-in-a-rabbit-critical-femoral-defect-by-means-of-magnetic-hydroxyapatite-macroporous-scaffolds
#5
A Russo, M Bianchi, M Sartori, M Boi, G Giavaresi, D M Salter, M Jelic, M C Maltarello, A Ortolani, S Sprio, M Fini, A Tampieri, M Marcacci
Magnetic scaffolds have recently attracted significant attention in tissue engineering due to the prospect of improving bone tissue formation by conveying soluble factors such as growth factors, hormones, and polypeptides directly to the site of implantation, as well as to the possibility of improving implant fixation and stability. The objective of this study was to compare bone tissue formation in a preclinical rabbit model of critical femoral defect treated either with a hydroxyapatite (HA)/magnetite (90/10 wt %) or pure HA porous scaffolds at 4 and 12 weeks after implantation...
February 15, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28198550/birth-injuries-to-growth-plates-a-sheep-in-wolves-clothing
#6
Jerrin Varghese, Matthew Teng, Mingqian Huang, Dvorah Balsam
Growth plate injuries (Salter-Harris type 1 or physeal fractures) of the long bones in the newborn are easily misdiagnosed as joint fractures with dislocations due to their nonossified epiphyses on plain radiographs. Diagnosis with musculoskeletal ultrasound (US) is advantageous due to its ability to visualize the nonossified epiphysis. We present two cases of humeral growth plate fractures in newborns, one at the shoulder (proximal humerus) and the other at the elbow (distal humerus). These cases emphasize the importance of quick and noninvasive diagnosis with US to avoid unnecessary intervention...
February 15, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28194488/adult-onset-idiopathic-chondrolysis-of-the-hip
#7
Liam Z Yapp, Liusaidh McClymont, Ian Beggs, Paul Gaston, Donald M Salter
We report the case of a 23-year-old man diagnosed with adult-onset idiopathic chondrolysis of the hip. Chondrolysis of the hip is a disorder most frequently seen in children who have suffered with slipped capital femoral epiphyses. Idiopathic chondrolysis of the hip is extremely rare and to our knowledge, its onset has never been documented in adults aged over 20. With reference to the available medical literature, we summarise the current clinical management of this unusual but important cause of young adult hip pain...
February 13, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28185935/progesterone-transfer-among-cohabitating-female-big-brown-bats-eptesicus-fuscus
#8
Lucas J Greville, Tyler Pollock, Joseph C Salter, Paul A Faure, Denys deCatanzaro
Experiments using female mice and bats have demonstrated that tritium-labeled 17β-estradiol ((3)H-E2) can be absorbed via cutaneous and intranasal routes and distributed to reproductive and neural tissues. Radioactivity has also been measured in tissues of untreated females after 48 h cohabitation with (3)H-E2 injected males. The present study was designed to quantify steroid transfer among female bats. Radioactive quantification via liquid scintillation counting revealed absorption of tritium-labeled progesterone ((3)H-P4) in adult females 1 h after cutaneous and intranasal application (10 μCi)...
February 6, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28165143/potentially-modifiable-factors-associated-with-physical-activity-in-individuals-with-multiple-sclerosis
#9
Nadia Reider, Amber R Salter, Gary R Cutter, Tuula Tyry, Ruth Ann Marrie
Physical activity levels among persons with multiple sclerosis (MS) are worryingly low. We aimed to identify the factors associated with physical activity for people with MS, with an emphasis on factors that have not been studied previously (bladder and hand dysfunction) and are potentially modifiable. This study was a secondary analysis of data collected in the spring of 2012 during the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry. NARCOMS participants were surveyed regarding smoking using questions from the Behavioral Risk Factor Surveillance Survey; disability using the Patient Determined Disease Steps; fatigue, cognition, spasticity, sensory, bladder, vision and hand function using self-reported Performance Scales; health literacy using the Medical Term Recognition Test; and physical activity using questions from the Health Information National Trends Survey...
February 6, 2017: Research in Nursing & Health
https://www.readbyqxmd.com/read/28164055/proximal-tibial-epiphysis-injury-flexion-type-salter-harris-type-1
#10
Pratik Israni, Mangesh Panat
INTRODUCTION: Fractures of the proximal tibial epiphysis rare. It has been estimated that fractures of the upper tibial epiphysis account for 0.5-3.1% of all epiphyseal injuries. Who had no neurovascular deficit, with fixed extension deformity at the left knee was treated early with closed reduction techniques. CASE REPORT: We present a case of a 16-year-old boy who while playing cricket on the road was hit by a car. The patient presented in emergency room with extremely swollen knee and soft tissue swelling (hemarthrosis), he was unable to lift his leg actively due to severe pain because of hamstrings spasm, and he had no wound over his left knee and had no other associated injuries...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28164054/a-very-rare-presentation-of-type-1-monteggia-equivalent-fracture-with-ipsilateral-fracture-of-distal-forearm-approach-with-outcome-case-report
#11
Dhananjay Singh, Bhanu Awasthi, Vikas Padha, Sanjay Thakur
INTRODUCTION: We report a case of Type 1 Monteggia equivalent injury with intact radio-capitellar congruity, associated with epiphyseal fracture of distal radius and distal ulna shaft in an 11-year-old boy. There are only a few cases of Monteggia or Monteggia equivalent injury with ipsilateral forearm fractures in children, and injury pattern being reported by us is not only rare but also the only case reported thus far to the best of our knowledge, Sood et al. described Type 1 equivalent with epiphyseal injuries of both radius and ulna Osada et al...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28162324/-517-potential-barriers-for-achieving-exercise-maintenance-among-trauma-exposed-female-veterans-with-fibromyalgia
#12
C Lonberger, S McSheffrey, K Allsup, M Sillice, M Driscoll, D Higgins, A Tyzik, M Gerber, E Scioli-Salter
No abstract text is available yet for this article.
April 2016: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28152945/choosing-wisely-opportunities-for-improving-value-of-cancer-care-in-the-deep-south
#13
Gabrielle Betty Rocque, Kelly Kenzik, Bradford E Jackson, Yufeng Li, Aras Acemgil, Richard A Taylor, Terri Salter, Edward E Partridge
: 13 Background: Under the Choosing Wisely (CW) Campaign, the American Society of Clinical Oncology (ASCO) and the American Society of Therapeutic Radiology and Oncology (ASTRO) recommend against non-evidence-based costly medications, tests, and procedures. CW recommendation adherence in the Deep South is largely unknown, and opportunities to reduce overuse and costs may exist. METHODS: Analysis of administrative claims and tumor registry data from 12 cancer centers of the University of Alabama Health System Cancer Community Network, for Medicare beneficiaries ≥65 years old with cancer...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28145951/outcome-after-combined-pelvic-and-femoral-osteotomies-in-patients-with-legg-calv%C3%A3-perthes-disease
#14
N Mosow, E Vettorazzi, S Breyer, K Ridderbusch, R Stücker, M Rupprecht
BACKGROUND: The aim of this study was to evaluate the outcome at skeletal maturity of combined pelvic and femoral varus osteotomies in children with Legg-Calvé-Perthes (LCP) disease. METHODS: From January 1998 to December 2009, 69 patients with LCP disease underwent combined osteotomies at our institution. Fifty-two children (19 girls and 33 boys) met the inclusion criteria and were enrolled in the study. The LCP disease was classified and the cases of all patients were reviewed at skeletal maturity...
February 1, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28132121/assessment-of-caregiver-inventory-for-rett-syndrome
#15
Jane B Lane, Amber R Salter, Nancy E Jones, Gary Cutter, Joseph Horrigan, Steve A Skinner, Walter E Kaufmann, Daniel G Glaze, Jeffrey L Neul, Alan K Percy
Rett syndrome (RTT) requires total caregiver attention and leads to potential difficulties throughout life. The Caregiver Burden Inventory, designed for Alzheimer disease, was modified to a RTT Caregiver Inventory Assessment (RTT CIA). Reliability and face, construct, and concurrent validity were assessed in caregivers of individuals with RTT. Chi square or Fisher's exact test for categorical variables and t tests or Wilcoxon two-sample tests for continuous variables were utilized. Survey completed by 198 caregivers; 70 caregivers completed follow-up assessment...
January 28, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28130045/hematopoietic-processes-in-eosinophilic-asthma
#16
Brittany M Salter, Roma Sehmi
Airway eosinophilia is a hallmark of allergic asthma and understanding mechanisms that promote increases in lung eosinophil numbers is important for effective pharmaco-therapeutic development. It has become evident that expansion of hemopoietic compartments in the bone marrow promotes differentiation and trafficking of mature eosinophils to the airways. Hematopoietic progenitor cells egress the bone marrow and home to the lungs, where in-situ differentiative processes within the tissue provide an ongoing source of pro-inflammatory cells...
January 24, 2017: Chest
https://www.readbyqxmd.com/read/28108251/discovery-of-7-3-piperazin-1-yl-phenyl-pyrrolo-2-1-f-1-2-4-triazin-4-amine-derivatives-as-highly-potent-and-selective-pi3k%C3%AE-inhibitors
#17
Lan-Ying Qin, Zheming Ruan, Robert J Cherney, T G Murali Dhar, James Neels, Carolyn A Weigelt, John S Sack, Anurag S Srivastava, Lyndon A M Cornelius, Joseph A Tino, Kevin Stefanski, Xiaomei Gu, Jenny Xie, Vojkan Susulic, Xiaoxia Yang, Melissa Yarde-Chinn, Stacey Skala, Ruth Bosnius, Christine Goldstein, Paul Davies, Stefan Ruepp, Luisa Salter-Cid, Rajeev S Bhide, Michael A Poss
As demonstrated in preclinical animal models, the disruption of PI3Kδ expression or its activity leads to a decrease in inflammatory and immune responses. Therefore, inhibition of PI3Kδ may provide an alternative treatment for autoimmune diseases, such as RA, SLE, and respiratory ailments. Herein, we disclose the identification of 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives as highly potent, selective and orally bioavailable PI3Kδ inhibitors. The lead compound demonstrated efficacy in an in vivo mouse KLH model...
January 10, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28106992/discovery-of-n-pyridin-4-yl-1-5-naphthyridin-2-amines-as-potential-tau-pathology-pet-tracers-for-alzheimer-s-disease
#18
Frederik J R Rombouts, José-Ignacio Andrés, Manuela Ariza, José Manuel Alonso, Nigel Austin, Astrid Bottelbergs, Lu Chen, Vladimir Chupakhin, Erna Cleiren, Katleen Fierens, Alberto Fontana, Xavier Langlois, Joseph E Leenaerts, Jonas Mariën, Carolina Martínez Lamenca, Rhys Salter, Mark E Schmidt, Paula Te Riele, Cindy Wintmolders, Andrés A Trabanco, Wei Zhang, Gregor Macdonald, Dieder Moechars
A mini-HTS on 4000 compounds selected using 2D fragment-based similarity and 3D pharmacophoric and shape similarity to known selective tau aggregate binders identified N-(6-methylpyridin-2-yl)quinolin-2-amine 10 as a novel potent binder to human AD aggregated tau with modest selectivity versus aggregated β-amyloid (Aβ). Initial medicinal chemistry efforts identified key elements for potency and selectivity, as well as suitable positions for radiofluorination, leading to a first generation of fluoroalkyl-substituted quinoline tau binding ligands with suboptimal physicochemical properties...
February 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28093026/out-of-sight-out-of-mind-racial-retrieval-cues-increase-the-accessibility-of-social-justice-concepts
#19
Phia S Salter, Nicholas J Kelley, Ludwin E Molina, Luyen T Thai
Photographs provide critical retrieval cues for personal remembering, but few studies have considered this phenomenon at the collective level. In this research, we examined the psychological consequences of visual attention to the presence (or absence) of racially charged retrieval cues within American racial segregation photographs. We hypothesised that attention to racial retrieval cues embedded in historical photographs would increase social justice concept accessibility. In Study 1, we recorded gaze patterns with an eye-tracker among participants viewing images that contained racial retrieval cues or were digitally manipulated to remove them...
January 16, 2017: Memory
https://www.readbyqxmd.com/read/28081210/mutations-in-hyal2-encoding-hyaluronidase-2-cause-a-syndrome-of-orofacial-clefting-and-cor-triatriatum-sinister-in-humans-and-mice
#20
Martina M A Muggenthaler, Biswajit Chowdhury, S Naimul Hasan, Harold E Cross, Brian Mark, Gaurav V Harlalka, Michael A Patton, Miho Ishida, Elijah R Behr, Sanjay Sharma, Kenneth Zahka, Eissa Faqeih, Brian Blakley, Mike Jackson, Melissa Lees, Vernon Dolinsky, Leroy Cross, Philip Stanier, Claire Salter, Emma L Baple, Fowzan S Alkuraya, Andrew H Crosby, Barbara Triggs-Raine, Barry A Chioza
Orofacial clefting is amongst the most common of birth defects, with both genetic and environmental components. Although numerous studies have been undertaken to investigate the complexities of the genetic etiology of this heterogeneous condition, this factor remains incompletely understood. Here, we describe mutations in the HYAL2 gene as a cause of syndromic orofacial clefting. HYAL2, encoding hyaluronidase 2, degrades extracellular hyaluronan, a critical component of the developing heart and palatal shelf matrix...
January 2017: PLoS Genetics
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