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https://www.readbyqxmd.com/read/28814293/regulation-of-human-airway-smooth-muscle-cell-migration-and-relevance-to-asthma
#1
REVIEW
Brittany Salter, Cara Pray, Katherine Radford, James G Martin, Parameswaran Nair
Airway remodelling is an important feature of asthma pathogenesis. A key structural change inherent in airway remodelling is increased airway smooth muscle mass. There is emerging evidence to suggest that the migration of airway smooth muscle cells may contribute to cellular hyperplasia, and thus increased airway smooth muscle mass. The precise source of these cells remains unknown. Increased airway smooth muscle mass may be collectively due to airway infiltration of myofibroblasts, neighbouring airway smooth muscle cells in the bundle, or circulating hemopoietic progenitor cells...
August 16, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28814104/factors-associated-with-low-neighborhood-cohesion-among-women-living-with-hiv-impacted-by-social-structural-inequities-in-british-columbia
#2
Kalysha Closson, Alexis K Palmer, Alexandra B Collins, Kate Salters, Wendy Zhang, Julio S G Montaner, Robert S Hogg, Surita Parashar
Built and social environments, including one's perception of their environment, are important determinants of health. The intersection of gender and HIV status may complicate the role of neighborhood cohesion in safety, personal well-being, and health outcomes for populations impacted by social and structural inequities. Among women in particular, social cohesion within the neighborhood they reside in may have a greater influence on health outcomes compared to their male counterparts. We sought to examine perception of neighborhood cohesion (validated scale with a range 0-100, with higher scores indicating higher perceived neighborhood cohesion) among women living with HIV, impacted by social-structural inequities, receiving combination antiretroviral therapy, and enrolled in the Longitudinal Investigations into Supportive Ancillary health services (LISA) study in British Columbia, Canada...
August 17, 2017: AIDS Care
https://www.readbyqxmd.com/read/28812936/investigation-of-goldmann-perimetry-in-evaluation-of-patients-for-upper-eyelid-blepharoplasty
#3
John D Pemberton, Michael Salter, Aaron Fay, Bradley Thuro, Horace Spencer, Omar Dajani
PURPOSE: To determine if preoperative Goldmann Visual Field (GVF) testing in patients with functional dermatochalasis accurately depicts the postoperative superior visual field (SVF) outcome. METHODS: A prospective cohort study was done to compare preoperative and postoperative GVF field tests in patients undergoing upper eyelid blepharoplasty for treatment of dermatochalasis. This study was conducted in accordance with the Declaration of Helsinki and approved by the University of Arkansas for Medical Sciences institutional review board...
August 16, 2017: Orbit
https://www.readbyqxmd.com/read/28768791/the-correlation-between-salter-s-criteria-for-avascular-necrosis-of-the-femoral-head-and-kalamchi-s-prognostic-classification-following-the-treatment-of-developmental-dysplasia-of-the-hip
#4
Y Tsukagoshi, M Kamegaya, H Kamada, T Saisu, M Morita, J Kakizaki, Y Tomaru, M Yamazaki
AIMS: The aim of this study was to evaluate the correlation between Salter's criteria and Kalamchi's classification of avascular necrosis in patients treated for developmental dysphasia of the hip (DDH). PATIENTS AND METHODS: The study involved a retrospective analysis of 123 patients (123 hips) with DDH treated by operative and non-operative reduction before the age of two years, with a minimum follow-up of ten years. Salter's criteria (S1 to S4) were determined from radiographs obtained at one to two years post-reduction, whilst the Kalamchi grade was determined from radiographs obtained at ten or more years of age...
August 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28766993/streamlined-edss-for-use-in-multiple-sclerosis-clinical-practice-development-and-cross-sectional-comparison-to-edss
#5
Laura E Baldassari, Amber R Salter, Erin E Longbrake, Anne H Cross, Robert T Naismith
BACKGROUND: The Expanded Disability Status Scale (EDSS) is the standard measure of disability in multiple sclerosis clinical trials. The EDSS has limited application in the clinical setting due to required completion time and scoring complexity. Systematically recording an objective, simplified, less time-intensive, and neurologist-derived disability score would be beneficial for patient care. OBJECTIVE: To develop and validate a streamlined version of the Expanded Disability Status Scale (sEDSS) for clinical monitoring...
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28745719/vip-cortical-conductors-set-the-tone-for-chronic-pain
#6
Erika K Harding, Michael W Salter
No abstract text is available yet for this article.
July 26, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/28740937/impact-of-prone-versus-supine-positioning-on-small-bowel-dose-with-pelvic-intensity-modulated-radiation-therapy
#7
Victor J Gonzalez, Craig R Hullett, Lindsay Burt, Prema Rassiah-Szegedi, Vikren Sarkar, Jonathan D Tward, Lisa J Hazard, Y Jessica Huang, Bill J Salter, David K Gaffney
PURPOSE: To report the results of a prospective study that compares small bowel doses during prone and supine pelvic intensity modulated radiation therapy. METHODS AND MATERIALS: Ten patients receiving pelvic radiation therapy each had 2 intensity modulated radiation therapy plans generated: supine and prone on a belly board (PBB). Computed tomography on rails was performed weekly throughout treatment in both positions (10 scans per patient). After image fusion, doses to small bowel (SB) loops and clinical target volume were calculated for each scan...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28735839/epidemiology-of-proximal-humeral-fractures-a-detailed-survey-of-711-patients-in-a-metropolitan-area
#8
Daniele Passaretti, Vittorio Candela, Pasquale Sessa, Stefano Gumina
BACKGROUND: Literature lacks data concerning several epidemiologic aspects of proximal humeral fractures (PHFs). METHODS: This retrospective study included 711 consecutive patients (209 men, 502 women) who sustained a PHF in the last 3 years. Participants were divided into 2 groups, adults and children. Data regarding age, sex, date, and fracture side were collected. According to the mechanism of injury, we arbitrarily distinguished 7 subgroups. PHFs were classified according to the head-greater-lesser-shaft (HGLS)-Hertel classification and to the Salter-Harris classification using x-ray and computed tomography imaging...
July 20, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28727731/pregnancy-incidence-and-intention-after-hiv-diagnosis-among-women-living-with-hiv-in-canada
#9
Kate Salters, Mona Loutfy, Alexandra de Pokomandy, Deborah Money, Neora Pick, Lu Wang, Shahab Jabbari, Allison Carter, Kath Webster, Tracey Conway, Daniele Dubuc, Nadia O'Brien, Karene Proulx-Boucher, Angela Kaida
BACKGROUND: Pregnancy incidence rates among women living with HIV (WLWH) have increased over time due to longer life expectancy, improved health status, and improved access to and HIV prevention benefits of combination antiretroviral therapy (cART). However, it is unclear whether intended or unintended pregnancies are contributing to observed increases. METHODS: We analyzed retrospective data from the Canadian HIV Women's Sexual and Reproductive Health Cohort Study (CHIWOS)...
2017: PloS One
https://www.readbyqxmd.com/read/28696683/standard-free-bioanalytical-approach-for-absolute-quantitation-of-drug-metabolites-utilizing-biosynthesis-of-reciprocal-radio-and-stable-isotopologues-and-its-application
#10
Yong Gong, Jie Chen, Yifan Shi, Heng-Keang Lim, Naidong Weng, Rhys Salter
The following work describes a combined enzymatic and bioanalytical method that permits absolute quantitation of metabolites in biological samples without the requirement for reference metabolite standards. This technique was exemplified using a radio ((14)C) isotopologue and a stable ((13)C6) isotopologue of acetaminophen as substrates for in vitro biosynthesis of the corresponding radio and stable isotope labeled metabolites, namely, (14)C- and (13)C6-glucuronides and sulfates. By supplanting the use of authentic metabolite standards, traditionally used to calibrate (13)C6-metabolites via liquid chromatography-tandem mass spectrometry (LC-MS/MS), (13)C6-metabolites were radiocalibrated by their (14)C-isotopologues via liquid chromatography coupled with radioactivity detection and mass spectrometry (LC-RAD/MS)...
July 25, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28690745/closed-reduction-of-a-traumatic-hip-dislocation-in-children-case-report
#11
Achraf El Bakkaly, Fouad Ettayebi, Houda Oubeja, Mounir Erraji, Hicham Zerhouni
Traumatic dislocation of the hip in children is a rare disease. It only represents 5% of hip dislocations in all age groups. Before 10 years, the mechanism is often a minimal domestic accident; after 10 years, the dislocation occurs with the waning of an accident of the public highway. It is different from that of the adult by its rarity, its ease of reduction and better prognosis. This is an emergency trauma: risk necrosis of the femoral head (If delayed reduction). We report a rare case of a 3 year old boy, who suffered from bipolar trauma after a fall near his height of his house causing him a detachment of the right humerus and post-traumatic dislocation of the left hip...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28682837/closed-loop-and-decision-assist-guided-fluid-therapy-of-human-hemorrhage
#12
Gabriel Hundeshagen, George C Kramer, Nicole Ribeiro Marques, Michael G Salter, Aristides K Koutrouvelis, Husong Li, Daneshvari R Solanki, Alexander Indrikovs, Roger Seeton, Sheryl N Henkel, Michael P Kinsky
OBJECTIVES: We sought to evaluate the efficacy, efficiency, and physiologic consequences of automated, endpoint-directed resuscitation systems and compare them to formula-based bolus resuscitation. DESIGN: Experimental human hemorrhage and resuscitation. SETTING: Clinical Research Laboratory. SUBJECTS: Healthy volunteers. INTERVENTIONS: Subjects (n = 7) were subjected to hemorrhage and underwent a randomized fluid resuscitation scheme on separate visits 1) formula-based bolus resuscitation; 2) semiautonomous (decision assist) fluid administration; and 3) fully autonomous (closed loop) resuscitation...
July 4, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28676523/macrophage-11%C3%AE-hsd1-deficiency-promotes-inflammatory-angiogenesis
#13
Zhenguang Zhang, Agnes E Coutinho, Janet Tak Yun Man, Tiina M J Kipari, Patrick Hadoke, Donald M Salter, Jonathan R Seckl, Karen Chapman
11β-hydroxysteroid dehydrogenase-1 (11β-HSD1) predominantly converts inert glucocorticoids into active forms, thereby contributing to intracellular glucocorticoid levels. 11β-HSD1 is dynamically regulated during inflammation, including in macrophages where it regulates phagocytic capacity. The resolution of inflammation in some disease models including inflammatory arthritis, is impaired by 11β-HSD1 deficiency or inhibition. However, 11β-HSD1 deficiency/inhibition also promotes angiogenesis, which is beneficial in mouse models of surgical wound healing, myocardial infarction or obesity...
July 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28671877/single-screw-fixation-of-adolescent-salter-ii-proximal-humeral-fractures-biomechanical-analysis-of-the-one-pass-door-lock-technique
#14
Mark Carl Miller, Christopher N Redman, Ronald J Mistovich, Muturi Muriuki, Mark J Sangimino
BACKGROUND: Pin fixation of Salter-II proximal humeral fractures in adolescents approaching skeletal maturity has potential complications that can be avoided with single-screw fixation. However, the strength of screw fixation relative to parallel and diverging pin fixation is unknown. To compare the biomechanical fixation strength between these fixation modalities, we used synthetic composite humeri, and then compared these results in composite bone with cadaveric humeri specimens. METHODS: Parallel pinning, divergent pinning, and single-screw fixation repairs were performed on synthetic composite humeri with simulated fractures...
June 30, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28671188/revising-the-hygroscopicity-of-inorganic-sea-salt-particles
#15
P Zieger, O Väisänen, J C Corbin, D G Partridge, S Bastelberger, M Mousavi-Fard, B Rosati, M Gysel, U K Krieger, C Leck, A Nenes, I Riipinen, A Virtanen, M E Salter
Sea spray is one of the largest natural aerosol sources and plays an important role in the Earth's radiative budget. These particles are inherently hygroscopic, that is, they take-up moisture from the air, which affects the extent to which they interact with solar radiation. We demonstrate that the hygroscopic growth of inorganic sea salt is 8-15% lower than pure sodium chloride, most likely due to the presence of hydrates. We observe an increase in hygroscopic growth with decreasing particle size (for particle diameters <150 nm) that is independent of the particle generation method...
July 3, 2017: Nature Communications
https://www.readbyqxmd.com/read/28665197/increased-ige-b-cells-in-sputum-but-not-blood-bone-marrow-or-tonsils-after-inhaled-allergen-challenge-in-subjects-with-asthma
#16
John-Paul Oliveria, Brittany M Salter, Jonathan MacLean, Shweta Kotwal, Ashley Smith, Jeffrey M Harris, Heleen Scheerens, Roma Sehmi, Gail M Gauvreau
No abstract text is available yet for this article.
July 1, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28661948/continuous-in-home-symptom-and-mobility-measures-for-individuals-with-multiple-sclerosis-a-case-presentation
#17
Pamela Newland, Alyssa Kimutis, Amber Salter, Louise Flick, Florian P Thomas, Marilyn Rantz, Marjorie Skubic
Gait impairment represents one of the most common and disabling symptoms of multiple sclerosis (MS). To identify which temporal or spatial parameters of gait could be used as outcome measures in interventional studies of individuals with MS with different levels of disability, we evaluated characteristics of these parameters in a case study of 3 participants with MS, using 1 case as an exemplar and the other participants as validation. A case study of an exemplar participant was conducted with a 67-year-old woman with secondary progressive MS served as exemplar, with 2 other participants (52 and 55 years old) as validation...
August 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28638969/introduction-childhood-and-disability
#18
EDITORIAL
Erica K Salter
From growth attenuation therapy for severely developmentally disabled children to the post-natal management of infants with trisomy 13 and 18, pediatric treatment decisions regularly involve assessments of the probability and severity of a child's disability. Because these decisions are almost always made by surrogate decision-makers (parents and caregivers) and because these decision-makers must often make decisions based on both prognostic guesses and potentially biased quality of life judgments, they are among the most ethically complex in pediatric care...
June 21, 2017: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/28637489/synaptoimmunology-roles-in-health-and-disease
#19
REVIEW
Robert Nisticò, Eric Salter, Celine Nicolas, Marco Feligioni, Dalila Mango, Zuner A Bortolotto, Pierre Gressens, Graham L Collingridge, Stephane Peineau
Mounting evidence suggests that the nervous and immune systems are intricately linked. Many proteins first identified in the immune system have since been detected at synapses, playing different roles in normal and pathological situations. In addition, novel immunological functions are emerging for proteins typically expressed at synapses. Under normal conditions, release of inflammatory mediators generally represents an adaptive and regulated response of the brain to immune signals. On the other hand, when immune challenge becomes prolonged and/or uncontrolled, the consequent inflammatory response leads to maladaptive synaptic plasticity and brain disorders...
June 20, 2017: Molecular Brain
https://www.readbyqxmd.com/read/28633789/displaced-salter-harris-type-i-distal-fibula-fractures-two-case-reports-and-a-review-of-the-literature
#20
Jeremy Korsh, Stephen Adolfsen
Salter-Harris type I (SH-I) fractures of the distal fibula are commonly encountered in pediatric orthopedics. We describe 2 unique cases of adolescents with completely displaced SH-I distal fibula fractures that were treated operatively. In the first case, a closed reduction attempt failed and the patient required open reduction and internal fixation of the distal fibula and syndesmosis. The syndesmotic ligaments were avulsed from the distal fibular metaphysis. In the second case, closed reduction of the distal fibula fracture was partially successful, but anatomic reduction could not be achieved without open reduction...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
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