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https://www.readbyqxmd.com/read/28427709/upper-limb-impairment-is-associated-with-use-of-assistive-devices-and-unemployment-in-multiple-sclerosis
#1
Ruth Ann Marrie, Gary R Cutter, Tuula Tyry, Stacey S Cofield, Robert Fox, Amber Salter
BACKGROUND: Individuals with multiple sclerosis (MS) frequently suffer from impaired sensory function, reduced strength and tremor in the upper limbs, which may interfere with upper limb function. However, upper limb impairment in MS is under-recognized and understudied. We aimed to evaluate the prevalence of upper limb impairment in a large sample of persons with MS; the association between upper limb function and employment status in MS; and the frequency of use of assistive devices aimed at addressing upper limb impairments...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28422515/allergen-induced-increases-in-sputum-levels-of-group-2-innate-lymphoid-cells-in-asthmatic-subjects
#2
Ruchong Chen, Steven G Smith, Brittany Salter, Amani El-Gammal, John Paul Oliveria, Caitlin Obminski, Rick Watson, Paul M O'Byrne, Gail M Gauvreau, Roma Sehmi
RATIONALE: Group 2 innate lymphoid cells (ILC2), a major source of type 2 cytokines, initiate eosinophilic inflammatory responses in murine models of asthma. OBJECTIVES: Investigate the role of ILC2 in allergen-induced airway eosinophilic responses in atopic asthmatics. METHODS: Using a diluent-controlled allergen challenge cross-over study, where all subjects (n=10) developed allergen-induced early and late responses , airway eosinophilia and increased methacholine airway responsiveness, bone marrow, blood and sputum samples were collected pre- and post-inhalation challenge...
April 19, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28418213/pain-thresholds-supra-threshold-pain-and-lidocaine-sensitivity-in-patients-with-erythromelalgia-including-the-i848tmutation-in-nav-1-7
#3
T Helås, D Sagafos, I P Kleggetveit, H Quiding, B Jönsson, M Segerdahl, Z Zhang, H Salter, M Schmelz, E Jørum
OBJECTIVES: Nociceptive thresholds and supra-threshold pain ratings as well as their reduction upon local injection with lidocaine were compared between healthy subjects and patients with erythromelalgia (EM). METHODS: Lidocaine (0.25, 0.50, 1.0 or 10 mg/mL) or placebo (saline) was injected intradermally in non-painful areas of the lower arm, in a randomized, double-blind manner, to test the effect on dynamic and static mechanical sensitivity, mechanical pain sensitivity, thermal thresholds and supra-threshold heat pain sensitivity...
April 18, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28410587/overview-of-cancer-incidence-and-mortality-among-people-living-with-hiv-aids-in-british-columbia-canada-implications-for-haart-use-and-nadm-development
#4
Connie G Chiu, Danielle Smith, Kate A Salters, Wendy Zhang, Steve Kanters, David Milan, Julio S G Montaner, Andy Coldman, Robert S Hogg, Sam M Wiseman
BACKGROUND: The objective of this study is to evaluate the incidence of non-AIDS defining malignancies (NADMs) among people living with HIV/AIDS (PLWHA) in British Columbia, focusing on clinical correlates, highly active antiretroviral therapy (HAART) use, and survival, in order to elucidate mechanisms for NADM development. METHODS: A retrospective population based analysis was carried out for individuals with HIV/AIDS that began their treatment between 1996 and 2008...
April 14, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28405783/how-do-clinical-genetics-consent-forms-address-the-familial-approach-to-confidentiality-and-incidental-findings-a-mixed-methods-study
#5
Sandi Dheensa, Gillian Crawford, Claire Salter, Michael Parker, Angela Fenwick, Anneke Lucassen
Genetic test results can be relevant to patients and their relatives. Questions thus arise around whether clinicians regard genetic information as confidential to individuals or to families, and about how they broach this and other issues, including the potential for incidental findings, in consent (forms) for genetic testing. We conducted a content analysis of UK-wide genetic testing consent forms and interviewed 128 clinicians/laboratory scientists. We found that almost all genetic services offered patients multiple, sometimes unworkable, choices on forms, including an option to veto the use of familial genetic information to benefit relatives...
April 12, 2017: Familial Cancer
https://www.readbyqxmd.com/read/28396585/phase-heterogeneity-in-carbonate-production-by-marine-fish-influences-their-roles-in-sediment-generation-and-the-inorganic-carbon-cycle
#6
Michael A Salter, Alastair R Harborne, Chris T Perry, Rod W Wilson
Marine teleost fish are important carbonate producers in neritic and oceanic settings. However, the fates of the diverse carbonate phases (i.e., mineral and amorphous forms of CaCO3) they produce, and their roles in sediment production and marine inorganic carbon cycling, remain poorly understood. Here we quantify the carbonate phases produced by 22 Bahamian fish species and integrate these data with regional fish biomass data from The Bahamas to generate a novel platform-scale production model that resolves these phases...
April 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28385071/treatment-of-missing-data-in-follow-up-studies-of-randomised-controlled-trials-a-systematic-review-of-the-literature
#7
Thomas R Sullivan, Lisa N Yelland, Katherine J Lee, Philip Ryan, Amy B Salter
BACKGROUND/AIMS: After completion of a randomised controlled trial, an extended follow-up period may be initiated to learn about longer term impacts of the intervention. Since extended follow-up studies often involve additional eligibility restrictions and consent processes for participation, and a longer duration of follow-up entails a greater risk of participant attrition, missing data can be a considerable threat in this setting. As a potential source of bias, it is critical that missing data are appropriately handled in the statistical analysis, yet little is known about the treatment of missing data in extended follow-up studies...
April 1, 2017: Clinical Trials: Journal of the Society for Clinical Trials
https://www.readbyqxmd.com/read/28380753/hybrid-laser-written-waveguides-in-fused-silica-for-low-loss-and-polarization-independence
#8
Jun Guan, Xiang Liu, Patrick S Salter, Martin J Booth
Photonic integrated circuits (PICs) written with an ultrashort pulsed laser provide advantages in a range of applications, such as photon-based quantum information processing, where low insertion loss and low polarization dependence are critical concerns. Here we demonstrate the inscription of hybrid waveguides in fused silica at a pulse repetition rate of 1MHz that fulfill both these criteria. The mechanisms for propagation and coupling losses are identified and decoupled, with separate sections of the waveguide minimizing for each and an adiabatic mode conversion between the two...
March 6, 2017: Optics Express
https://www.readbyqxmd.com/read/28365987/an-experimental-and-master-equation-study-of-the-kinetics-of-oh-od-so2-the-limiting-high-pressure-rate-coefficients
#9
Mark A Blitz, Robert J Salter, Dwayne E Heard, Paul W Seakins
The kinetics of the reaction OH/OD + SO2 were studied using a laser flash photolysis/laser-induced fluorescence technique. Evidence for two-photon photolysis of SO2 at 248 nm is presented and quantified, and which appears to have been evident to some extent in most previous photolysis studies, potentially leading to values for the rate coefficient k1 that are too large. The kinetics of the reaction OH(v = 0) + SO2 (T = 295 K, p = 25-300 torr) were measured under conditions where SO2 photolysis was taken into account...
April 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28363245/an-experimental-study-of-the-kinetics-of-oh-od-v-1-2-3-so2-the-limiting-high-pressure-rate-coefficients-as-a-function-of-temperature
#10
Mark A Blitz, Robert J Salter, Dwayne E Heard, Paul W Seakins
The kinetics of the reaction OH/OD(v = 1,2,3) + SO2 were studied using a photolysis/laser-induced fluorescence technique. The rate coefficients OH/OD(v = 1,2,3) + SO2, k1, over the temperature range of 295-810 K were used to determine the limiting high-pressure limit k1(∞). This method is usually applicable if the reaction samples the potential well of the adduct HOSO2 and if intramolecular vibrational relaxation is fast. In the present case, however, the rate coefficients showed an additional fast removal contribution as evidenced by the increase in k1 with vibrational level; this behavior together with its temperature dependence is consistent with the existence of a weakly bound complex on the potential energy surface prior to adduct formation...
April 20, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28351749/the-link-between-smoking-status-and-co-morbid-conditions-in-individuals-with-multiple-sclerosis-ms
#11
Pamela Newland, Louise Flick, Amber Salter, David Dixon, Mark P Jensen
BACKGROUND: In individuals with multiple sclerosis (MS) comorbidities and quality of life (QOL) may be affected by tobacco use. OBJECTIVE: To evaluate the associations between smoking status, in particular quit attempts, and comorbidities among individuals with MS. METHODS: We used a web-based survey to obtain cross-sectional data from 335 individuals with MS who were members of the Gateway Chapter of the National MS Society email registry...
March 23, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28347506/antidepressant-associated-microscopic-colitis-a-case-report-and-literature-review
#12
Thomas G Salter, Mark D Williams
No abstract text is available yet for this article.
January 19, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28334801/a-systematic-review-of-the-physical-activity-assessment-tools-used-in-primary-care
#13
Toby O Smith, Máire C McKenna, Charlotte Salter, Wendy Hardeman, Kathryn Richardson, Melvyn Hillsdon, Carly A Hughes, Nicholas Steel, Andy P Jones
Background.: Primary care is an ideal setting for physical activity interventions to prevent and manage common long-term conditions. To identify those who can benefit from such interventions and to deliver tailored support, primary care professionals (e.g. GPs, practice nurses, physiotherapists, health care assistants) need reliable and valid tools to assess physical activity. However, there is uncertainty about the best-performing tool. Objective.: To identify the tools used in the literature to assess the physical activity in primary care and describe their psychometric properties...
February 21, 2017: Family Practice
https://www.readbyqxmd.com/read/28323542/organized-abuse-in-adulthood-survivor-and-professional-perspectives
#14
Michael Salter
This paper reports on the preliminary findings of a qualitative study of Australian women disclosing organized abuse in adulthood and the mental health professionals who treat them. Drawing on interviews with survivors and mental health professionals, the paper analyses the fraught relationship between mental health and physical safety for adults subject to organized abuse. The therapeutic progress of adult organized abuse victims can be disrupted by ongoing threats, stalking, and group violence, which in turn reinforces the dissociative responses and pathological attachments that render them vulnerable to revictimization...
February 23, 2017: Journal of Trauma & Dissociation
https://www.readbyqxmd.com/read/28320058/regional-differences-between-perisynovial-and-infrapatellar-adipose-tissue-depots-and-their-response-to-class-ii-and-iii-obesity-in-patients-with-oa
#15
Natalia S Harasymowicz, Nick D Clement, Asim Azfer, Richard Burnett, Donald M Salter, A Hamish W R Simpson
OBJECTIVE: Obesity is associated with an increased risk of developing Osteoarthritis (OA), which is postulated to be secondary to inflammation from adipose tissue (AT). There are peri-articular adipose depots in synovial joints, the association of this tissue with OA has not been extensively explored. The aim of this study was to investigate differences in local AT depots in knees with OA and changes related to class II and III obesity. METHODS: Synovium and the infrapatellar fat pad (IPFP) were collected during total knee replacement from 69 patients with end-stage OA...
March 20, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28300049/type-i-monteggia-with-ipsilateral-fracture-of-distal-radius-epiphyseal-injury-a-rare-case-report
#16
Gaurav Mundada, Sohael Mohammed Khan, Shraddha K Singhania, Varun Gupta, Pradeep K Singh, Saherish Khan
Simultaneous Monteggia injuries of the elbow and ipsilateral fracture distal radius with epiphyseal injury both bone are a unique case. A unique case of a Type I Monteggia fracture equivalent with ipsilateral fracture distal radius with epiphyseal injury (Salter-Harris Type II) in a child is reported. We describe the management of this unique fracture and discuss the possible mechanism of injury. We have highlighted a rare combination of injuries. Early recognition and prompt surgical intervention can lead to a satisfactory outcome even in these complex injuries...
January 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/28299936/development-of-decarboxylative-cyanation-reactions-for-c-13-c-14-carboxylic-acid-labeling-using-an-electrophilic-cyanating-reagent
#17
Fengbin Song, Rhys Salter, Lu Chen
Degradation-reconstruction approaches for isotope labeling synthesis have been known for their remarkable efficiency, but applications are scarce due to some fundamental limitations of the chemistries developed to date. The decarboxylative cyanation reaction, as a degradation-reconstruction approach, is especially useful in rapid carboxylic acid carbon isotope labeling, however development toward its application as a widespread technique has stalled at the early stages due to numerous limitations which include somewhat narrow applicability...
March 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28298551/high-hypothetical-interest-in-physician-assisted-death-in-multiple-sclerosis
#18
Ruth Ann Marrie, Amber Salter, Tuula Tyry, Gary R Cutter, Stacey Cofield, Robert J Fox
OBJECTIVE: To assess the opinions of persons with multiple sclerosis (MS) regarding physician-assisted death (PAD). METHODS: We surveyed participants in the North American Research Committee on Multiple Sclerosis (NARCOMS) Registry regarding PAD. For each of 5 hypothetical situations, respondents indicated whether they definitely would, probably would, probably would not, or definitely would not consider PAD. They also reported their sociodemographics, disability status using Patient-Determined Disease Steps, depression status, pain status, religiosity, and degree of social support...
March 15, 2017: Neurology
https://www.readbyqxmd.com/read/28297331/comparison-of-surface-matching-and-target-matching-for-image-guided-pelvic-radiation-therapy-for-both-supine-and-prone-patient-positions
#19
Hui Zhao, Brian Wang, Vikren Sarkar, Prema Rassiah-Szegedi, Y Jessica Huang, Martin Szegedi, Long Huang, Victor Gonzalez, Bill Salter
We investigate the difference between surface matching and target matching for pelvic radiation image guidance. The uniqueness of our study is that all patients have multiple CT-on-rails (CTOR) scans to compare to corresponding AlignRT images. Ten patients receiving pelvic radiation were enrolled in this study. Two simulation CT scans were performed in supine and prone positions for each patient. Body surface contours were generated in treatment planning system and exported to AlignRT to serve as reference images...
May 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28274407/comparison-of-2-transabdominal-ultrasound-image-guidance-techniques-for-prostate-and-prostatic-fossa-radiation-therapy
#20
COMPARATIVE STUDY
Bill J Salter, Martin Szegedi, Christine Boehm, Vikren Sarkar, Prema Rassiah-Szegedi, Brian Wang, Hui Zhao, Jessica Huang, Long Huang, Kris Kokeny, Jonathan D Tward
PURPOSE: Our clinic is a long-term user of a first-generation transabdominal (TA) biplanar (2.5-dimensional [2.5D]) ultrasound image guidance (USIG) system for prostate cancer treatments. We are also an early adopter and development partner for a new, second-generation, fully 3D USIG system that allows for volumetric TA localization of the prostate. This new system has been evaluated at our institution by direct comparison with the previously established first-generation TA method for prostate alignment...
March 2017: Practical Radiation Oncology
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