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https://www.readbyqxmd.com/read/27917331/percutaneous-cannulated-screw-fixation-for-pediatric-epiphyseal-ankle-fractures
#1
Özgür Çiçekli, Güzelali Özdemir, Mustafa Uysal, Vedat Biçici, İzzet Bingöl
BACKGROUND: Ankle injuries are among the most common injuries in children. The aim of this study was to compare the efficacies of two percutaneous fixation methods after closed reduction in physeal ankle fractures. METHODS: We reviewed the cases of 24 patients with a mean age of 12.29 years; 16 were male, and 8 were female. Only patients with fractures of Salter-Harris types 2, 3, and 4 with displacements greater than 2 mm were included in the study. Patients were treated with closed reduction manipulation and percutaneous screw fixation...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27906469/corrective-osteotomy-of-a-metacarpal-deviation-caused-by-fracture-in-a-9-month-old-german-fleckvieh-heifer
#2
Theresa S Tschoner, Roberto G Köstlin, Melanie Feist
OBJECTIVE: To describe the surgical treatment of a metacarpal deviation caused by an untreated Salter-Harris type I fracture in a heifer. STUDY DESIGN: Case report. ANIMAL: 9-month-old German Fleckvieh heifer. METHODS: A closing wedge osteotomy was performed to correct deviation of fused metacarpal III and IV. A triangular bone wedge was removed and the proximal and distal fragments of the bone were brought into apposition and stabilized with an 11-hole T-plate...
December 1, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27882811/the-ao-pediatric-comprehensive-classification-of-long-bone-fractures-pccf-part-ii
#3
Alexander Joeris, Nicolas Lutz, Andrea Blumenthal, Theddy Slongo, Laurent Audigé
Background and purpose - To achieve a common understanding when dealing with long bone fractures in children, the AO Pediatric Comprehensive Classification of Long Bone Fractures (AO PCCF) was introduced in 2007. As part of its final validation, we present the most relevant fracture patterns in the lower extremities of a representative population of children classified according to the PCCF. Patients and methods - We included patients up to the age of 17 who were diagnosed with 1 or more long bone fractures between January 2009 and December 2011 at either of 2 tertiary care university hospitals in Switzerland...
November 24, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27882802/the-ao-pediatric-comprehensive-classification-of-long-bone-fractures-pccf-part-i
#4
Alexander Joeris, Nicolas Lutz, Andrea Blumenthal, Theddy Slongo, Laurent Audigé
Background and purpose - To achieve a common understanding when dealing with long bone fractures in children, the AO Pediatric Comprehensive Classification of Long Bone Fractures (AO PCCF) was introduced in 2007. As part of its final validation, we present the most relevant fracture patterns in the upper extremities of a representative population of children classified according to the PCCF. Patients and methods - We included children and adolescents (0-17 years old) diagnosed with 1 or more long bone fractures between January 2009 and December 2011 at the university hospitals in Bern and Lausanne (Switzerland)...
November 24, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27849102/kirschner-wire-fixation-of-salter-harris-type-iv-fracture-of-the-lateral-aspect-of-the-humeral-condyle-in-growing-dogs-a-retrospective-study-of-35-fractures
#5
Filippo Cinti, Guido Pisani, Luca Vezzoni, Bruno Peirone, Aldo Vezzoni
OBJECTIVES: To evaluate the use of Kirschner wires for treatment of fractures of the lateral aspect of the humeral condyle in growing dogs. METHODS: Retrospective analysis of 35 elbow fractures (33 dogs) of the lateral aspect of the humeral condyle treated by insertion of multiple transcondylar and one anti-rotational Kirschner wires. Radiographic and clinical re-evaluations were carried out immediately after surgery, at four weeks and, when required, at eight weeks postoperatively...
November 16, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
https://www.readbyqxmd.com/read/27847682/examining-the-joint-effect-of-disability-health-behaviors-and-comorbidity-on-mortality-in-ms
#6
Amber Salter, Tuula Tyry, Guoqiao Wang, Robert J Fox, Gary Cutter, Ruth Ann Marrie
BACKGROUND: In multiple sclerosis (MS), comorbidities have been associated with disability progression and an increased risk of mortality. We investigated the association between comorbidities and mortality in MS after accounting for disability and health behaviors. METHODS: We followed North American Research Committee on Multiple Sclerosis (NARCOMS) Registry participants who completed the Fall 2006 survey on comorbidities until death (reported or matched in the National Death Index) or date of last follow-up in 2014...
October 2016: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/27846394/restoring-p53-function-in-human-melanoma-cells-by-inhibiting-mdm2-and-cyclin-b1-cdk1-phosphorylated-nuclear-iaspp
#7
Min Lu, Hilde Breyssens, Victoria Salter, Shan Zhong, Ying Hu, Caroline Baer, Indrika Ratnayaka, Alex Sullivan, Nicholas R Brown, Jane Endicott, Stefan Knapp, Benedikt M Kessler, Mark R Middleton, Christian Siebold, E Yvonne Jones, Elena V Sviderskaya, Jonathan Cebon, Thomas John, Otavia L Caballero, Colin R Goding, Xin Lu
No abstract text is available yet for this article.
November 14, 2016: Cancer Cell
https://www.readbyqxmd.com/read/27844080/peeling-the-astronomical-onion
#8
Alexander Rosu-Finsen, Demian Marchione, Tara L Salter, James W Stubbing, Wendy A Brown, Martin R S McCoustra
Water ice is the most abundant solid in the Universe. Understanding the formation, structure and multiplicity of physicochemical roles for water ice in the cold, dense interstellar environments in which it is predominantly observed is a crucial quest for astrochemistry as these are regions active in star and planet formation. Intuitively, we would expect the mobility of water molecules deposited or synthesised on dust grain surfaces at temperatures below 50 K to be very limited. This work delves into the thermally-activated mobility of H2O molecules on model interstellar grain surfaces...
November 15, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27825797/an-analog-of-camptothecin-inactive-against-topoisomerase-i-is-broadly-neutralizing-of-hiv-1-through-inhibition-of-vif-dependent-apobec3g-degradation
#9
Ryan P Bennett, Ryan A Stewart, Priscilla A Hogan, Roger G Ptak, Marie K Mankowski, Tracy L Hartman, Robert W Buckheit, Beth A Snyder, Jason D Salter, Guillermo A Morales, Harold C Smith
Camptothecin (CPT) is a natural product discovered to be active against various cancers through its ability to inhibit Topoisomerase I (TOP1). CPT analogs also have anti-HIV-1 (HIV) activity that was previously shown to be independent of TOP1 inhibition. We show that a cancer inactive CPT analog (O2-16) inhibits HIV infection by disrupting multimerization of the HIV protein Vif. Antiviral activity depended on the expression of the cellular viral restriction factor APOBEC3G (A3G) that, in the absence of functional Vif, has the ability to hypermutate HIV proviral DNA during reverse transcription...
December 2016: Antiviral Research
https://www.readbyqxmd.com/read/27807193/ptpn22-is-a-critical-regulator-of-fc%C3%AE-receptor-mediated-neutrophil-activation
#10
Sonja Vermeren, Katherine Miles, Julia Y Chu, Donald Salter, Rose Zamoyska, Mohini Gray
Neutrophils act as a first line of defense against bacterial and fungal infections, but they are also important effectors of acute and chronic inflammation. Genome-wide association studies have established that the gene encoding the protein tyrosine phosphatase nonreceptor 22 (PTPN22) makes an important contribution to susceptibility to autoimmune disease, notably rheumatoid arthritis. Although PTPN22 is most highly expressed in neutrophils, its function in these cells remains poorly characterized. We show in this article that neutrophil effector functions, including adhesion, production of reactive oxygen species, and degranulation induced by immobilized immune complexes, were reduced in Ptpn22(-/-) neutrophils...
December 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27803638/disability-progression-after-switching-from-natalizumab-to-fingolimod-or-interferon-beta-glatiramer-acetate-therapies-a-narcoms-analysis
#11
Stacey S Cofield, Robert J Fox, Tuula Tyry, Amber R Salter, Denise Campagnolo
Background: Physicians must weigh the benefits against the risk of progressive multifocal leukoencephalopathy (PML) in patients treated with natalizumab, especially beyond 2 years. However, disability progression associated with switching therapies versus continuing natalizumab therapy after 2 years has not been fully evaluated. Methods: In this retrospective analysis using the NARCOMS Registry, disability progression (Patient-Determined Disease Steps [PDDS] scale) and physical health-related quality of life (HRQOL) worsening (12-item Short Form Health Status Survey Physical Component Score [SF-12 PCS]) were compared between participants switching to fingolimod (n = 50) or interferon beta (IFNβ)/glatiramer acetate (GA) (n = 71) therapy and those continuing natalizumab (n = 406) after 2 years or more of treatment (median follow-up: natalizumab, 4 years; fingolimod, 4...
September 2016: International Journal of MS Care
https://www.readbyqxmd.com/read/27800206/immune-complex-mediated-glomerulonephritis-with-acute-thrombotic-microangiopathy-following-newly-detected-hepatitis-b-virus-infection-in-a-kidney-transplant-recipient
#12
Tracey Salter, Hannah Burton, Sam Douthwaite, William Newsholme, Catherine Horsfield, Rachel Hilton
Hepatitis B virus (HBV) presents a risk to patients and staff in renal units. To minimise viral transmission, there are international and UK guidelines recommending HBV immunisation for patients commencing renal replacement therapy (RRT) and HBV surveillance in kidney transplant recipients. We report the case of a 56-year-old male who was immunised against HBV before starting haemodialysis. He received a deceased donor kidney transplant three years later, at which time there was no evidence of HBV infection...
2016: Case Reports in Transplantation
https://www.readbyqxmd.com/read/27781142/pathological-nociceptors-in-two-patients-with-erythromelalgia-like-symptoms-and-rare-genetic-nav-1-9-variants
#13
Inge P Kleggetveit, Roland Schmidt, Barbara Namer, Hugh Salter, Tormod Helås, Martin Schmelz, Ellen Jørum
INTRODUCTION: The sodium channel Nav 1.9 is expressed in peripheral nociceptors and has recently been linked to human pain conditions, but the exact role of Nav 1.9 for human nociceptor excitability is still unclear. METHODS: C-nociceptors from two patients with late onset of erythromelalgia-like pain, signs of small fiber neuropathy, and rare genetic variants of Nav 1.9 (N1169S, I1293V) were assessed by microneurography. RESULTS: Compared with patients with comparable pain phenotypes (erythromelalgia-like pain without Nav-mutations and painful polyneuropathy), there was a tendency toward more activity-dependent slowing of conduction velocity in mechanoinsensitive C-nociceptors...
October 2016: Brain and Behavior
https://www.readbyqxmd.com/read/27755266/pediatric-phalanx-fractures
#14
Joshua M Abzug, Karan Dua, Andrea Sesko Bauer, Roger Cornwall, Theresa O Wyrick
Phalangeal fractures are the most common type of hand fracture that occurs in the pediatric population and account for the second highest number of emergency department visits for fractures in the United States. The incidence of phalangeal fractures is the highest in children aged 10 to 14 years, which coincides with the time that most children begin playing contact sports. Younger children are more likely to sustain a phalangeal fracture in the home setting as a result of crush and laceration injuries. Salter-Harris type II fractures of the proximal phalanx are the most common type of finger fracture...
November 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27739425/glucocorticoid-regulation-of-atp-release-from-spinal-astrocytes-underlies-diurnal-exacerbation-of-neuropathic-mechanical-allodynia
#15
Satoru Koyanagi, Naoki Kusunose, Marie Taniguchi, Takahiro Akamine, Yuki Kanado, Yui Ozono, Takahiro Masuda, Yuta Kohro, Naoya Matsunaga, Makoto Tsuda, Michael W Salter, Kazuhide Inoue, Shigehiro Ohdo
Diurnal variations in pain hypersensitivity are common in chronic pain disorders, but the underlying mechanisms are enigmatic. Here, we report that mechanical pain hypersensitivity in sciatic nerve-injured mice shows pronounced diurnal alterations, which critically depend on diurnal variations in glucocorticoids from the adrenal glands. Diurnal enhancement of pain hypersensitivity is mediated by glucocorticoid-induced enhancement of the extracellular release of ATP in the spinal cord, which stimulates purinergic receptors on microglia in the dorsal horn...
October 14, 2016: Nature Communications
https://www.readbyqxmd.com/read/27726358/identification-of-tricyclic-agonists-of-sphingosine-1-phosphate-receptor-1-s1p1-employing-ligand-based-drug-design
#16
Hai-Yun Xiao, Scott H Watterson, Charles M Langevine, Anurag S Srivastava, Soo S Ko, Yanlei Zhang, Robert Joseph Cherney, Weiwei Guo, John L Gilmore, James E Sheppeck, Dauh-Rurng Wu, Peng Li, Duraisamy Ramasamy, Pirama Nayagam Arunachalam, Arvind Mathur, Tracy L Taylor, David J Shuster, Kim W McIntyre, Ding Ren Shen, Melissa Yarde, Mary Ellen Cvijic, Anthony M Marino, Praveen V Balimane, Zheng Yang, Dana M Banas, Georgia Cornelius, Celia J D Arienzo, Bethanne M Warrack, Lois D Lehman-McKeeman, Luisa M Salter-Cid, Jenny H Xie, Joel C Barrish, Percy H Carter, Alaric J Dyckman, T G Murali Dhar
Fingolimod (1) is the first approved oral therapy for the treatment of relapsing remitting multiple sclerosis. While the phosphorylated metabolite of fingolimod was found to be a non-selective S1P receptor agonist, agonism specifically of S1P1 is responsible for the peripheral blood lymphopenia believed to be key to its efficacy. Identification of modulators that maintain activity on S1P1 while sparing activity on other S1P receptors could offer equivalent efficacy with reduced liabilities. We disclose in this paper a ligand based drug design approach that led to the discovery of a series of potent tricyclic agonists of S1P1 with selectivity over S1P3 and were efficacious in a pharmacodynamic model of suppression of circulating lymphocytes...
October 11, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27694232/listeria-monocytogenes-in-stone-fruits-linked-to-a-multistate-outbreak-enumeration-of-cells-and-whole-genome-sequencing
#17
Yi Chen, Laurel S Burall, Yan Luo, Ruth Timme, David Melka, Tim Muruvanda, Justin Payne, Charles Wang, George Kastanis, Anna Maounounen-Laasri, Antonio J De Jesus, Phillip E Curry, Robert Stones, Okumu K'Aluoch, Eileen Liu, Monique Salter, Thomas S Hammack, Peter S Evans, Mickey Parish, Marc W Allard, Atin Datta, Errol A Strain, Eric W Brown
: In 2014, the identification of stone fruits contaminated with Listeria monocytogenes led to the subsequent identification of a multistate outbreak. Simultaneous detection and enumeration of L. monocytogenes were performed on 105 fruits, each weighing 127 to 145 g, collected from 7 contaminated lots. The results showed that 53.3% of the fruits yielded L. monocytogenes (lower limit of detection, 5 CFU/fruit), and the levels ranged from 5 to 2,850 CFU/fruit, with a geometric mean of 11...
December 15, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/27687241/the-role-of-mitogen-activated-protein-kinases-and-sterol-receptor-coactivator-1-in-tgf-%C3%AE-regulated-expression-of-genes-implicated-in-macrophage-cholesterol-uptake
#18
Rebecca C Salter, Pelagia Foka, Thomas S Davies, Hayley Gallagher, Daryn R Michael, Tim G Ashlin, Dipak P Ramji
The anti-atherogenic cytokine TGF-β inhibits macrophage foam cell formation by suppressing the expression of key genes implicated in the uptake of modified lipoproteins. We have previously shown a critical role for p38 MAPK and JNK in the TGF-β-mediated regulation of apolipoprotein E expression in human monocytes. However, the roles of these two MAPK pathways in the control of expression of key genes involved in the uptake of modified lipoproteins in human macrophages is poorly understood and formed the focus of this study...
September 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27685819/spontaneous-pneumothorax-a-collapse-in-management
#19
G Watson, N Salter, J Ryan
Revised guidelines for the management of spontaneous pneumothoraces were published by the British Thoracic Society in 2010, however compliance remains poor. A retrospective review was performed on patients diagnosed with a pneumothorax over a 26 month period (January 2012 to March 2014). Of the 57 patients identified, 43 (75%) were diagnosed with spontaneous pneumothorax. 12 patients (21%) had pre-existing lung disease, and 16 patients (28%) admitted to having had a previously documented pneumothorax. 19 patients (33%) were reported as smokers...
2016: Irish Medical Journal
https://www.readbyqxmd.com/read/27685606/allergen-induced-increases-in-interleukin-25-and-interleukin-25-receptor-expression-in-mature-eosinophils-from-atopic-asthmatics
#20
Wei Tang, Steven G Smith, Brittany Salter, John Paul Oliveria, Patrick Mitchell, Graeme M Nusca, Karen Howie, Gail M Gauvreau, Paul M O'Byrne, Roma Sehmi
BACKGROUND: Interleukin (IL)-25 plays a pivotal role in type 2 immune responses. In a baseline cross-sectional study, we previously showed that IL-25 plasma levels and IL-25 receptor (IL-25R: IL-17RA, IL-17RB, and IL-17RA/RB) expression on mature blood eosinophils are increased in atopic asthmatics compared to normal nonatopic controls. This study investigated allergen-induced changes in IL-25 and IL-25R expression in eosinophils from asthmatics. METHODS: Dual responder atopic asthmatics (n = 14) were enrolled in this randomized diluent-controlled crossover allergen challenge study...
2016: International Archives of Allergy and Immunology
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