Hui Li, Yaning Guo, Wei Su, Huan Zhang, Xiaoxi Wei, Xinyu Ma, Shuwen Gong, Gaoyang Qu, Lin Zhang, Hong Xu, Fuhai Shen, Shoufang Jiang, Dingjie Xu, Jinlong Li
Inorganic arsenic is a well-established environmental toxicant linked to acute liver injury, fibrosis, and cancer. While oxidative stress, pyroptosis, and ferroptosis are known contributors, the role of PTEN-induced kinase 1 (PINK1)-mediated mitophagy in arsenic-induced hepatic immunotoxicity remains underexplored. Our study revealed that acute arsenic exposure prompts differentiation of hepatic dendritic cells (DCs) and T helper (Th) 1, Th2, Th17, and regulatory T (Treg) cells, alongside increased transcription factors and cytokines...
April 22, 2024: Ecotoxicology and Environmental Safety