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Lymph node metastasis thyroid carcinoma

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https://www.readbyqxmd.com/read/29680915/medullary-thyroid-carcinoma-application-of-thyroid-imaging-reporting-and-data-system-ti-rads-classification
#1
Gabin Yun, Yeo Koon Kim, Sang Il Choi, Ji-Hoon Kim
PURPOSE: To evaluate the applicability of ultrasound (US)-based Thyroid Imaging Reporting and Data System (TI-RADS) for evaluating medullary thyroid carcinoma (MTC). MATERIALS AND METHODS: US images and medical records of patients with cytopathology-confirmed MTC between June 2003 and November 2016 were retrospectively reviewed. Four independent reviewers (two experienced and two inexperienced radiologists) evaluated 57 pre-operative US images of patients with MTC for shape, composition, echogenicity, margin, calcification of the MTC nodules, and categorized the nodules using TI-RADS classification...
April 21, 2018: Endocrine
https://www.readbyqxmd.com/read/29676367/sclerosing-mucoepidermoid-carcinoma-with-eosinophilia-of-thyroid-gland-not-so-indolent-a-neoplasm
#2
Anila Kunjulekshmi Amma Raveendran Nair, Nebu A George, Rejnish Kumar, A Sreekumar, K Jayasree
A 58-year-old female, a known diabetic and hypertensive, presented with left-sided swelling on the anterior aspect of the neck of 1-year duration, which was rapidly increasing in size for the past 6 months. She was on Eltroxin for hypothyroidism for the past 1 year. Computed tomography study of the neck showed a nodule in the left lobe of thyroid which on fine-needle aspiration was suspicious for malignancy. Total thyroidectomy with left posterolateral lymph node dissection was done. Histopathological examination showed sclerosing mucoepidermoid carcinoma with eosinophilia (SMECE) of the thyroid gland with lymph node metastasis...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29665129/overexpression-of-epidermal-growth-factor-receptor-and-its-downstream-effector-focal-adhesion-kinase-correlates-with-papillary-thyroid-carcinoma-progression
#3
Sonja Šelemetjev, Aleksandar Bartolome, Tijana Išić Denčić, Ilona Đorić, Ivan Paunović, Svetislav Tatić, Dubravka Cvejić
Epidermal growth factor receptor (EGFR) and its downstream effector, focal adhesion kinase (FAK), have been shown to be overexpressed frequently in human malignancies and implicated in tumour aggressiveness. We aimed to investigate the relationship between EGFR and FAK expression and their possible correlation with the clinical phenotype of patients with papillary thyroid carcinoma (PTC). Expression profiles of EGFR and FAK were analysed in PTC tissue samples (n = 104) by immunohistochemistry and Western blotting...
April 17, 2018: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/29663723/intraocular-metastasis-of-medullary-thyroid-carcinoma-investigated-by-transscleral-fine-needle-aspiration-a-case-report-and-review-of-the-literature
#4
Małgorzata Gajdzis, Nathalie Cassoux, Maria Lesnik, Caroline Hoffmann, Nathalie Badois, Paweł Gajdzis, Jerzy Klijanienko
Medullary thyroid carcinoma occurs in a sporadic setting and may also be inherited in an autosomal dominant fashion, which is related with germline mutations of the RET gene. Metastases are often present at the time of a diagnosis-most frequently within the cervical lymph nodes, followed by the liver, lungs, and bones. Intraocular metastases are extremely rare. We present a case of choroidal metastasis as a first presentation of disease progression in a patient with Multiple Endocrine Neoplasia type 2A syndrome (MEN2A) who had undergone thyroidectomy 33 years earlier for medullary thyroid carcinoma...
April 16, 2018: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29615431/clinical-significance-of-ret-and-ras-mutations-in-sporadic-medullary-thyroid-cancer-a-meta-analysis
#5
Huy Gia Vuong, Toru Odate, Hanh T T Ngo, Thong Quang Pham, Thao T K Tran, Kunio Mochizuki, Tadao Nakazawa, Ryohei Katoh, Tetsuo Kondo
There are ongoing debates with respect to the prognostic roles of molecular biomarkers in sporadic medullary thyroid carcinoma (MTC). In this study, we aimed at investigating the prognostic value of RET and RAS mutations - the two most common mutations in sporadic MTCs. A search was conducted in four electronic databases. Relevant data were extracted and pooled into odds ratios (OR), mean differences (MD) and corresponding 95% confidence intervals (CI) using the random-effect model. We used Egger's regression test and visual of funnel plots to assess the publication bias...
April 3, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29603330/a-clinical-decision-support-system-using-ultrasound-textures-and-radiologic-features-to-distinguish-metastasis-from-tumor-free-cervical-lymph-nodes-in-patients-with-papillary-thyroid-carcinoma
#6
Ali Abbasian Ardakani, Reza Reiazi, Afshin Mohammadi
OBJECTIVES: This study investigated the potential of a clinical decision support approach for the classification of metastatic and tumor-free cervical lymph nodes (LNs) in papillary thyroid carcinoma on the basis of radiologic and textural analysis through ultrasound (US) imaging. METHODS: In this research, 170 metastatic and 170 tumor-free LNs were examined by the proposed clinical decision support method. To discover the difference between the groups, US imaging was used for the extraction of radiologic and textural features...
March 30, 2018: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29599647/prognostic-value-of-long-non-coding-rna-blacat1-in-patients-with-papillary-thyroid-carcinoma
#7
Denghui Liao, Gang Lv, Ting Wang, Jie Min, Yadong Wang, Shengchun Liu
Background: Long noncoding RNAs (lncRNAs) have been reported to have potential diagnostic and prognostic values for numerous cancers. However, the plasma expression of lncRNA BLACAT1 and its clinical value in patients with papillary thyroid cancer (PTC) remain unknown. Methods: The expression profile of BLACAT1 in 87 PTC patients (case group) and 36 patients with nodular goiter (control group) were investigated by qRT-PCR. The Kaplan-Meier method was used for RFS curves, and the univariate survival differences were analyzed by the log-rank test...
2018: Cancer Cell International
https://www.readbyqxmd.com/read/29593418/mir-622-suppresses-tumor-formation-by-directly-targeting-vegfa-in-papillary-thyroid-carcinoma
#8
Renjie Wang, Qingjie Ma, Linlin Ji, Yue Yao, Mengshi Ma, Qiang Wen
Background: MicroRNAs (miRNAs) were reportedly to play crucial roles in papillary thyroid carcinoma (PTC) tumorigenesis and development. Therefore, the discovery of miRNAs may provide a new and powerful tool for diagnosis and treatment of PTC. Purpose: The aim of this study was to investigate the biological function and underlying mechanism of miR-622 in PTC. Materials and methods: The expression levels of miR-622 in PTC patient tissues and cell lines were determined by quantitative RT-PCR (qRT-PCR)...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29588604/primary-mucinous-carcinoma-of-thyroid-gland-with-prominent-signet-ring-cell-differentiation-a-case-report-and-review-of-the-literature
#9
Jian Wang, Qie-Re Guli, Xiao-Cui Ming, Hai-Tao Zhou, Yong-Jie Cui, Yue-Feng Jiang, Di Zhang, Yang Liu
Purpose: This study reports a case of primary mucinous carcinoma of the thyroid gland with signet-ring-cell differentiation, and reviews the literature to evaluate its real incidence and the prognosis of these patients. Patients and methods: A 74-year-old Chinese woman, presenting with a mass in the right lobe of thyroid gland, came to the hospital. Computed tomography revealed a mass in the right lobe of the thyroid gland, accompanied with right neck lymphadenectasis and airway deviation caused by tumor compression...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29578160/concomitant-high-expression-of-survivin-and-vascular-endothelial-growth-factor-c-is-strongly-associated-with-metastatic-status-of-lymph-nodes-in-papillary-thyroid-carcinoma
#10
Sonja Selemetjev, Svetlana Savin, Ivan Paunovic, Svetislav Tatic, Dubravka Cvejic
Purpose: Papillary thyroid carcinoma (PTC) has a strong propensity to metastasize to regional lymph nodes which increases the risk of local-regional relapse and affects the course of the disease. Molecular pathogenesis of lymph node metastasis (LNM) is not yet fully understood. Survivin, a multifunctionale molecule involved in apoptosis, proliferation and angiogenesis, and vascular endothelial growth factor-C (VEGF-C) are suggested to be implicated in lymphatic metastases of human malignancies...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29575838/-study-on-the-relationship-between-ultrasonographic-features-of-papillary-thyroid-carcinoma-and-central-cervical-lymph-node-metastasis
#11
X Q Wang, W Wei, X Wei, Y Xu, H L Wang, X J Xing, S Zhang
Objective: To investigate the correlation between ultrasonographic features of papillary thyroid carcinoma and central cervical lymph node metastasis. Methods: We retrospectively analyzed 486 patients with papillary thyroid carcinoma(PTC), pathologically confirmed after surgery in Tianjin Medical University Cancer Institute & Hospital. All patients were divided into central cervical lymph node metastasis group and non-metastasis group. No lateral cervical lymph node metastasis was found in preoperative ultrasonography and postoperative pathology...
March 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29575557/reliable-sonographic-features-for-nodal-thyroglobulin-to-diagnose-recurrent-lymph-node-metastasis-from-papillary-thyroid-carcinoma
#12
He-Jiun Jiang, Che-Wei Wu, Feng-Yu Chiang, Hsin-Ying Clair Chiou, I-Ju Chen, Pi-Jung Hsiao
OBJECTIVES: Ultrasound guided aspiration cytology (US-FNAC) was previously used to diagnose lymph node metastasis of papillary thyroid carcinoma (PTC). Combined US-FNAC with nodal thyroglobulin (LN-FNA-Tg) significantly improved the diagnostic rate. However, diagnostic accuracy depends on proper node selection. Therefore, it is crucial to choose the nodes with reliable sonographic features to guide clinician for confirmation. DESIGN AND SETTING: Retrospective cohort study was done in one medical center within 2011 to 2014...
March 25, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29569965/analysis-of-risk-factors-for-cervical-lymph-node-metastases-in-patients-with-sporadic-medullary-thyroid-carcinoma
#13
Weina Fan, Cheng Xiao, Fusheng Wu
Objective Medullary thyroid carcinoma (MTC) is classified as either sporadic or inherited. This study was performed to analyze the risk factors for cervical lymph node metastases and predict the indication for prophylactic lateral neck dissection in patients with sporadic MTC. Methods Sixty-five patients with sporadic MTC were retrospectively reviewed. Univariate analysis with the chi-square test and multiple logistic regression analysis were applied to identify the clinicopathological features (sex, age, tumor size, number of tumor foci, capsule or vascular invasion, and others) associated with cervical lymph node metastases...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29563836/clinical-behaviors-of-rare-variants-of-papillary-thyroid-carcinoma-are-associated-with-survival-a-population-level-analysis
#14
Chenghao Jiang, Tong Cheng, Xucai Zheng, Shikai Hong, Song Liu, Jianjun Liu, Jing Wang, Shengying Wang
Objective: This study was to evaluate the risk factors of survival in patients with columnar cell variant (CCV) and encapsulated variant (ECV). Materials and methods: The Surveillance, Epidemiology, and End Results database (1988-2013) was used to compare the characteristics of CCV and ECV with those of classic papillary thyroid carcinoma (PTC). Survival was analyzed by the Kaplan-Meier method, the log-rank test, and Cox multivariate regression. Multivariate logistic regression was used to further analyze lymph node metastases and distant metastasis...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29562496/predictive-gene-signatures-of-nodal-metastasis-in-papillary-thyroid-carcinoma
#15
Kyu Young Choi, Jin Hwan Kim, Il Seok Park, Young Soo Rho, Gee Hwan Kwon, Dong Jin Lee
BACKGROUND: Cervical lymph node metastases (LNM) in papillary thyroid carcinomas (PTCs) are common and develop in approximately 30-80% of PTCs. The presence of cervical LNM significantly increases the rate of locoregional recurrence in PTCs. OBJECTIVE: To search for predictive gene signatures for nodal metastasis in PTCs. METHODS: We used unsupervised clustering with unbiased manner to compare molecular profiles between PTCs with nodal metastasis and PTCs without nodal metastasis using mRNA-seq of TCGA data...
March 1, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29550935/clinicopathologic-risk-factors-for-right-paraesophageal-lymph-node-metastasis-in-patients-with-papillary-thyroid-carcinoma
#16
Q A Yu, D K Ma, K P Liu, P Wang, C M Xie, Y H Wu, W J Dai, H C Jiang
OBJECTIVES: To investigate risk factors associated with right paraesophageal lymph node (RPELN) metastasis in patients with papillary thyroid carcinoma (PTC) and to determine the indications for right lymph node dissection. METHODS: Clinicopathologic data from 829 patients (104 men and 725 women) with PTC, operated on by the same thyroid surgery team at the First Affiliated Hospital of Harbin Medical University from January 2013 to May 2017, were analyzed. Overall, 309 patients underwent total thyroidectomy with bilateral lymph node dissection, 488 underwent right thyroid lobe and isthmic resection with right central compartment lymph node dissection, and 32 underwent near-total thyroidectomy (ipsilateral thyroid lobectomy with contralateral near-total lobectomy) with bilateral lymph node dissection...
March 17, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29545855/expression-of-serum-ampd1-in-thyroid-carcinoma-and-its-clinical-significance
#17
Tianzhou Zha, Haorong Wu
This study investigated the expression of adenosine monophosphate deaminase 1 (AMPD1) in serum of patients with papillary thyroid carcinoma (PTC) and its clinical significance. The expression levels of AMPD1 mRNA in serum of 157 patients with PTC and 100 normal controls were detected by real-time fluorescent quantitative polymerase chain reaction (PCR), and the relationships between expression level of AMPD1 in serum of PTC patients and clinicopathological factors as well as prognosis were analyzed. The results of real-time fluorescent quantitative PCR showed that the expression of AMPD1 mRNA in serum of PTC patients was lower than that in normal human serum (P<0...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29533940/usp33-is-a-biomarker-of-disease-recurrence-in-papillary-thyroid-carcinoma
#18
Meng Jia, Yaman Guo, Xiubo Lu
BACKGROUND/AIMS: To investigate the clinical significance and functional mechanisms of deubiquitinase USP33 in papillary thyroid carcinoma (PTC). METHODS: Immunohistochemistry staining was conducted to explore the expression of USP33 in PTC tissues and adjacent normal thyroid tissues. Patients' prognosis was evaluated by disease-free survival. The prognostic role of USP33 was tested by univariate and multivariate analyses. To confirm the effect of USP33 in cell proliferation and invasion, overexpression and knockdown of USP33 were performed in two PTC cell lines...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29532783/ultrasound-guided-radiofrequency-ablation-for-cervical-lymph-nodes-metastasis-from-papillary-thyroid-carcinoma
#19
Yang Guang, Yu-Kun Luo, Yan Zhang, Ming-Bo Zhang, Nan Li, Ying Zhang, Jie Tang
Objective To assess the effectiveness and safety of ultrasound-guided percutaneous radiofrequency ablation (RFA) for nonsurgical treatment of metastatic lymph nodes (LNs) in the neck from papillary thyroid carcinoma (PTC). Methods Totally 45 PTC patients who had been treated with total thyroidectomy and radioiodine therapy were enrolled in this retrospective study. A total of 71 metastatic LNs in the neck from PTC were confirmed by percutaneous biopsy. Follow-up consisted of conventional ultrasound,contrast-enhanced ultrasound,and thyroglobulin (Tg) measurement 1,3 and 6 months after RFA and then every 6 months...
February 28, 2018: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/29523762/functional-toll-like-receptor-4-overexpression-in-papillary-thyroid-cancer-by-mapk-erk-induced-ets1-transcriptional-activity
#20
Victoria Peyret, Magalí Nazar, Mariano Martin, Amado A Quintar, Elmer A Fernandez, Romina C Geysels, Cesar Fuziwara, María M Montesinos, Cristina A Maldonado, Pilar Santisteban, Edna T Kimura, Claudia G Pellizas, Juan P Nicola, Ana M Masini-Repiso
Emerging evidence suggests that unregulated Toll-like receptors (TLRs) signaling promotes tumor survival signals, thus favoring tumor progression. Here, the mechanism underlying TLR4 overexpression in papillary thyroid carcinomas (PTCs) mainly harboring the BRAFV600E mutation was studied. TLR4 was overexpressed in PTCs compared to non-neoplastic thyroid tissue. Moreover, paired clinical specimens of primary PTC and its lymph node metastasis showed a significant upregulation of TLR4 levels in the metastatic tissues...
March 9, 2018: Molecular Cancer Research: MCR
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