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Lymph node metastasis thyroid carcinoma

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https://www.readbyqxmd.com/read/29451143/familial-nonmedullary-thyroid-carcinoma-a-retrospective-analysis-of-117-families
#1
Ya-Bing Zhang, Xiao-Xin Wang, Xi-Wei Zhang, Zheng-Jiang Li, Jie Liu, Zhen-Gang Xu, Ping-Zhang Tang
Background: The first and most important step in characterizing familial nonmedullary thyroid carcinoma (NMTC) is to distinguish the true familial patients, which is the prerequisite for all accurate analyses. This study aimed to investigate whether patients from families with ≥3 first-degree relatives affected with NMTC have different characteristics than patients from families with only two affected members, and to compare these patients with those with sporadic disease. Methods: We analyzed the clinicopathological features and prognosis of 209 familial and 1120 sporadic cases of NMTC...
February 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29445071/a-case-report-of-thyroid-metastasis-from-p16-positive-oropharyngeal-squamous-cell-carcinoma
#2
Masao Takenobu, Sueyoshi Moritani, Kana Yoshioka, Tsuyoshi Morisaki, Hiroya Kitano
Thyroid metastasis from head and neck squamous cell carcinoma (SCC) is a very rare form of rarely observed metastatic thyroid tumor. We herein report a case of thyroid metastasis from oropharyngeal SCC (OSCC). The patient was a 68-year-old male diagnosed with p16-positive tonsillar OSCC on the right side with multiple lymph node metastases and a thyroid mass, which was determined as metastatic p16-positive OSCC by immunohistochemistry of specimens collected by fine-needle aspiration cytology (FNAC). He received one cycle of induction chemotherapy followed by concurrent chemoradiotherapy...
February 15, 2018: Endocrine Journal
https://www.readbyqxmd.com/read/29439716/risk-factors-of-lateral-lymph-node-metastasis-in-cn0-papillary-thyroid-carcinoma
#3
Daixing Hu, Jing Zhou, Wei He, Jie Peng, Yijia Cao, Haoyu Ren, Yu Mao, Yi Dou, Wei Xiong, Qi Xiao, Xinliang Su
BACKGROUND: Cervical lymph node metastasis of papillary thyroid carcinoma (PTC) is common. However, whether undergoing prophylactic central lymph node (CLN) dissection or lateral lymph node (LLN) dissections to prevent metastasis is still controversial. This study aimed to retrospectively investigate the risk factors of LLN metastasis in clinical lymph node-negative (cN0) PTC patients. METHODS: We retrospectively studied 783 lymph node-negative (cN0) PTC patients who underwent total thyroidectomy plus CLN dissection and LLN dissection...
February 13, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29439612/a-nomogram-based-on-the-characteristics-of-metastatic-lymph-nodes-to-predict-papillary-thyroid-carcinoma-recurrence
#4
Jianyong Lei, Jinjing Zhong, Zhihui Li, Tao Wei, Rixiang Gong, Jinqiang Zhu
BACKGROUND AND AIMS: The extent of metastatic LN invasion was not considered in the postoperative stratification of the recurrence risk of papillary thyroid carcinoma (PTC) in the 2015 American Thyroid Association (ATA) guidelines, and the recommended risk stratification cannot be applied to individuals. A nomogram based on these risk factors was developed based on the risk factors to predict individual recurrence risk. PATIENTS AND METHODS: Data from 1788 PTC patients at the West China Hospital and 306 cases from the Shang Jin Nan Fu Hospital between August 2013 and July 2015 were included in our study...
February 14, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29438531/characteristics-of-follicular-variant-papillary-thyroid-carcinoma-in-a-pediatric-cohort
#5
S L Samuels, L F Surrey, C P Hawkes, M Amberge, S Mostoufi-Moab, J E Langer, N S Adzick, K Kazahaya, T Bhatti, Z Baloch, V A LiVolsi, A J Bauer
Context: In adults, non-invasive follicular variant papillary thyroid carcinoma (FVPTC) is considered low risk for metastasis and persistent/recurrent disease. Objective: The goal of this study was to assess the clinical, sonographic, and histopathological features of FVPTC in a pediatric cohort. Design: A retrospective review of subjects < 19 years of age with papillary thyroid carcinoma (PTC) who underwent thyroidectomy between January 2010 and July 2015...
February 8, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29429179/-evaluation-of-central-lymph-node-dissection-for-papillary-thyroid-carcinoma-in-cn0-t1-t2
#6
S Y Zhao, Y H Ma, Z Yin, X X Zhan, R C Cheng, J Qian
Objective: To evaluate the application of the central lymph node dissection (CLND) for papillary thyroid carcinoma (PTC) in cN0 T1/T2. Methods: Retrospective analysis of 532 cases with PTC in cN0 T1/T2 who underwent CLND between October 2014 and September 2016 in the Department of Thyroid Surgery, the First Affiliated Hospital of the Kunming Medical University. The incidence of central lymph node (CLN) metastasis and risk factors were analyzed. Results: CLN metastasis rates: 41.2% (42/102) in males vs 34.9% (150/430) in females, P=0...
February 7, 2018: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/29427554/sporadic-pediatric-papillary-thyroid-carcinoma-harboring-the-etv6-ntrk3-fusion-oncogene-in-a-7-year-old-japanese-girl-a-case-report-and-review-of-literature
#7
Ryota Otsubo, Zhanna Mussazhanova, Yuko Akazawa, Ayako Sato, Katsuya Matsuda, Megumi Matsumoto, Hiroshi Yano, Michiko Matsuse, Norisato Mitsutake, Takao Ando, Daisuke Niino, Takeshi Nagayasu, Masahiro Nakashima
BACKGROUND: There have been great concerns about pediatric thyroid cancers after the accident at the Fukushima Daiichi Nuclear Power Plant in 2011. CASE PRESENTATION: We report a case of a 7-year-old Japanese girl with sporadic papillary thyroid carcinoma (PTC) harboring an ETV6/NTRK3 rearrangement. The patient presented with tumors in both lobes and underwent thyroidectomy followed by radioactive iodine (RAI) ablation. Histopathology showed a classic type of PTC with cervical lymph node metastasis...
February 10, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29416604/cunr-scoring-system-for-the-prediction-of-lateral-lymph-node-metastasis-in-papillary-thyroid-carcinoma
#8
Jianyong Lei, Gengpeng Li, Zhihui Li, R X Rong, Jingqiang Zhu
Objective: Our present study aimed to evaluate and compare the number and rate of central lymph node metastases (LNMs) for the prediction of lateral LNM (LLNM) in papillary thyroid carcinoma (PTC) and to develop a scoring system. Results: Capsule invasion, tumor location in the upper portion of the thyroid, an ipsilateral central compartment LNM number ≥3, and an ipsilateral central compartment LNM rate of ≥56% were identified as significant independent predictors of ipsilateral lateral LNM in PTC...
January 2, 2018: Oncotarget
https://www.readbyqxmd.com/read/29414634/anaplastic-thyroid-carcinoma-in-denmark-1996-2012-a-national-prospective-study-of-219-patients
#9
Gitte Bjørn Hvilsom, Stefano Christian Londero, Christoffer Holst Hahn, Sten Schytte, Henrik Baymler Pedersen, Peer Christiansen, Katalin Kiss, Stine Rosenkilde Larsen, Marie Louise Jespersen, Giedrius Lelkaitis, Christian Godballe
BACKGROUND: Anaplastic thyroid carcinoma (ATC) is the least common but most malignant thyroid cancer. We aimed to examine the characteristics as well as evaluate the incidence, prognostic factors, and if introduction of a fast track cancer program might influence survival in a cohort of ATC patients. METHODS: A cohort study based on prospective data from the national Danish thyroid cancer database DATHYRCA and the national Danish Pathology Register including 219 patients diagnosed from 1996 to 2012, whom were followed until death or through September 2014...
January 31, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29408504/autocrine-activation-of-platelet-derived-growth-factor-receptor-alpha-in-metastatic-papillary-thyroid-cancer
#10
Esther Ekpe Adewuyi, Jean Deschenes, Ana Lopez-Campistrous, Mireille Kattar, Sunita Ghosh, Todd P W McMullen
Metastatic dissemination of papillary thyroid cancer has been reported to be strongly associated with expression of platelet derived growth factor alpha (PDGFRα) and altered TTF1 function. However, the status of PDGF ligands in papillary thyroid cancer and the potential role of these ligands in metastatic disease are obscure. We assessed the prevalence of PDGF ligands in benign and malignant thyroid tumors to determine if ligand up-regulation is associated with alpha-isoform (PDGF-AA or PDGF-BB) or the beta-isoform (PDGF-BB or PDGF-DD) of PDGFR in individual tumors...
February 1, 2018: Human Pathology
https://www.readbyqxmd.com/read/29394564/-papillary-carcinoma-arising-in-thyroglossal-duct-cyst-in-the-right-lateral-neck
#11
Yusuke Wakasa, Susumu Oishi, Masaki Nara, Tsuyoshi Nozaki, Shuichi Yoshihara, Hiroshi Tateoka
A 47-year-old woman was admitted to our institution with the chief complaint of a right cervical mass. Imaging examination findings showed a cystic mass of 25mm with a nodular lesion in the right cervical region. Therefore, we performed extirpation of the right cervical cystic mass to allow diagnosis of the lesion. The histopathological findings showed a partial thyroid tissue on the cyst wall covered with glandular epithelium or metaplastic squamous epithelium, and tumor cells proliferating in the papillary form...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29391807/a-novel-tumor-suppressor-gene-ncoa5-is-correlated-with-progression-in-papillary-thyroid-carcinoma
#12
Zhou-Ci Zheng, Qing-Xuan Wang, Wei Zhang, Xiao-Hua Zhang, Du-Ping Huang
Background: In contrast to the excellent prognosis for papillary thyroid carcinoma (PTC), the high incidence of lymph node metastasis (LNM) markedly increases the risk of recurrence and secondary surgery. Thus, novel biomarkers must be urgently identified to assess LNM for patients with PTC. NCOA5 is deeply involved in the progression of human cancer; however, its role in thyroid cancer remains unknown. Patients and methods: Quantitative real-time polymerase chain reaction was conducted to investigate the expression of NCOA5 in PTC...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29390502/male-occult-breast-cancer-with-axillary-lymph-node-metastasis-as-the-first-manifestation-a-case-report-and-literature-review
#13
Ruixin Xu, Jianbin Li, Yingjie Zhang, Hongbiao Jing, Youzhe Zhu
RATIONALE: Occult breast cancer (OBC) is extremely rare in males with neither symptoms in the breast nor abnormalities upon imaging examination. PATIENT CONCERNS: This current case report presents a young male patient who was diagnosed with male OBC first manifesting as axillary lymph node metastasis. The physical and imaging examination showed no primary lesions in either breasts or in other organs. DIAGNOSES: The pathological results revealed infiltrating ductal carcinoma in the axillary lymph nodes...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383135/upregulation-of-rspo2-gpr48-lgr4-signaling-in-papillary-thyroid-carcinoma-contributes-to-tumor-progression
#14
Yea Eun Kang, Jin-Man Kim, Koon Soon Kim, Joon Young Chang, Mingyu Jung, Junguee Lee, Shinae Yi, Hyeon Woo Kim, Jung Tae Kim, Kyungmin Lee, Min Jeong Choi, Seul Ki Kang, Seong Eun Lee, Hyon-Seung Yi, Bon Seok Koo, Minho Shong
The signaling pathway involving the R-spondins and its cognate receptor, GPR48/LGR4, is crucial in development and carcinogenesis. However, the functional implications of the R-spondin-GPR48/LGR4 pathway in thyroid remain to be identified. The aim of this study was to investigate the role of R-spondin-GPR48/LGR4 signaling in papillary thyroid carcinomas. We retrospectively reviewed a total of 214 patients who underwent total thyroidectomy and cervical lymph node dissection for papillary thyroid carcinoma. The role of GPR48/LGR4 in proliferation and migration was examined in thyroid cancer cell lines...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29380524/noninvasive-encapsulated-follicular-variant-of-papillary-thyroid-carcinoma-should-it-also-be-reclassified-in-children
#15
Rachel A Mariani, Rachel Kadakia, Nicoleta C Arva
BACKGROUND: Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (noniEFVPTC) has low risk of adverse outcome in adults, warranting reclassification as noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP). In children, thyroid nodules have higher risk of malignancy and it is unknown if encapsulated FVPTC (EFVPTC) and infiltrative FVPTC (IFVPTC) tumors have different behavior. We analyzed the clinicopathologic features of follicular variant of papillary thyroid carcinoma (FVPTC) subtypes in our pediatric population to determine if noniEFVPTC has an indolent course as reported in adults...
January 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29374347/association-between-preoperative-thyrotrophin-and-clinicopathological-and-aggressive-features-of-papillary-thyroid-cancer
#16
Abbas Ali Tam, Didem Ozdemir, Cevdet Aydın, Nagihan Bestepe, Serap Ulusoy, Nuran Sungu, Reyhan Ersoy, Bekir Cakir
PURPOSE: We aimed to investigate the relation between preoperative serum thyrotrophin (TSH) and clinicopathological features in patients with papillary thyroid carcinoma (PTC) and microcarcinoma (PTMC). METHODS: Patients who underwent thyroidectomy and diagnosed to have benign nodular disease or PTC/PTMC in our clinic were evaluated retrospectively. Patients with a previous history of thyroid surgery, patients using antithyroid medications or thyroid hormone and patients with tumors known to be unresponsive to TSH were excluded...
January 27, 2018: Endocrine
https://www.readbyqxmd.com/read/29372373/excellent-prognosis-of-central-lymph-node-recurrence-free-survival-for-cn0m0-papillary-thyroid-carcinoma-patients-who-underwent-routine-prophylactic-central-node-dissection
#17
Yasuhiro Ito, Akira Miyauchi, Hiroo Masuoka, Mitsuhiro Fukushima, Minoru Kihara, Akihiro Miya
INTRODUCTION: In Japan, prophylactic central node dissection (p-CND) for papillary thyroid carcinoma (PTC) has been routinely performed in many institutions, including ours (Kuma Hospital, Japan). We evaluated the recurrence to a central lymph node in patients with cN0M0 PTC who underwent routine p-CND. MATERIALS AND METHODS: We enrolled 4301 patients with cN0M0 PTC who underwent an initial surgery between 1987 and 2005 (median age 51 years). The postoperative follow-up periods ranged from 4 to 362 months (median 164 months)...
January 25, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29361659/associations-between-bethesda-categories-and-tumor-characteristics-of-conventional-papillary-thyroid-carcinoma
#18
Vivian Youngjean Park, Eun-Kyung Kim, Jin Young Kwak, Jung Hyun Yoon, Hee Jung Moon
Purpose: The aim of this study was to investigate the associations of Bethesda categories III, V, and VI with the clinical and pathological features of thyroid nodules surgically confirmed as conventional papillary thyroid carcinomas (PTCs). Methods: We analyzed 1,990 consecutive patients diagnosed with conventional PTC at surgery with preoperative Bethesda categories III, V, or VI. We determined the odds ratio (ORs) of the clinical and pathological variables associated with categories III and V, using category VI as the reference...
November 22, 2017: Ultrasonography
https://www.readbyqxmd.com/read/29350102/preoperative-clinical-and-sonographic-predictors-for-lateral-cervical-lymph-node-metastases-in-sporadic-medullary-thyroid-carcinoma
#19
Hye-Seon Oh, Hyemi Kwon, Eyun Song, MinJi Jeon, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Suck Joon Hong, Won Bae Kim, YoungKee Shong, Jung Hwan Baek, Won Gu Kim
<b><i>Background</i></b> Total thyroidectomy and cervical lymph node (LN) dissection is generally recommended in patients with medullary thyroid carcinoma (MTC). However, there is no clear evidence for whom to perform prophylactic lateral neck dissection in MTC patients without evident lateral cervical lymph node (LCLN) metastasis in preoperative images. This study evaluated the preoperative features for predicting the LCLN metastasis of MTC. <b><i>Methods</i></b> We included 26 MTC patients with LCLN metastasis at initial surgery (N1b group) and 47 MTC patients without any LN metastasis or recurrence of disease (N0-NED group)...
January 19, 2018: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29343212/clinical-characteristics-of-subtypes-of-follicular-variant-papillary-thyroid-carcinoma
#20
Min Joo Kim, Jae-Kyung Won, Kyeong Cheon Jung, Ji-Hoon Kim, Sun Wook Cho, Do Joon Park, Young Joo Park
Background Among follicular variant papillary thyroid carcinomas (FVPTCs), the non-invasive encapsulated subtype has an excellent prognosis. For this reason, re-classification of non-invasive encapsulated FVPTC (EFVPTC) as a new entity called "non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP)" has been proposed, but controversy remains. To characterize non-invasive EFVPTC in an Asian population, we compared the clinicopathological features of each FVPTC subtype in a Korean population...
January 17, 2018: Thyroid: Official Journal of the American Thyroid Association
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