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Lymph node metastasis thyroid carcinoma

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https://www.readbyqxmd.com/read/28230037/mutl-homolog-1-expression-in-thyroid-carcinoma-and-its-clinical-significance
#1
Yi Lu, Baocheng Jiang, Ye Yuan, Jianping Fei, Jiyuan Wang
OBJECTIVE: The aim of this study was to evaluate the MutL homolog 1 (MLH1) protein expression in thyroid cancer patients and its association with clinical pathological characteristics. MATERIALS AND METHODS: Forty thyroid cancer tissues and 22 partial paired normal thyroid tissues from 40 thyroid cancer patients who received surgery were collected in this study. MLH1 protein expression was tested by immunohistochemical method for the 40 cancer tissues and 22 partial paired normal thyroid tissues...
December 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28225995/clinical-impact-of-thyroglobulin-tg-and-tg-autoantibody-tgab-measurements-in-needle-washouts-of-neck-lymph-node-biopsies-in-the-management-of-patients-with-papillary-thyroid-carcinoma
#2
M Cecilia Martins-Costa, Rui M B Maciel, Teresa S Kasamatsu, Claudia C D Nakabashi, Cleber P Camacho, Felipe Crispim, Elza S Ikejiri, M Conceição O Mamone, Danielle M Andreoni, Rosa Paula M Biscolla
Objectives: The presence of thyroglobulin (Tg) in needle washouts of fine needle aspiration biopsy (Tg-FNAB) in neck lymph nodes (LNs) suspected of metastasis has become a cornerstone in the follow-up of patients with papillary thyroid carcinoma (PTC). However, there are limited data regarding the measurement of anti-Tg antibodies in these washouts (TgAb-FNAB), and it is not clear whether these antibodies interfere with the assessment of Tg-FNAB or whether there are other factors that would more consistently justify the finding of low Tg-FNAB in metastatic LNs...
February 13, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28223546/skip-lateral-lymph-node-metastasis-leaping-over-the-central-neck-compartment-in-papillary-thyroid-carcinoma
#3
Jianyong Lei, Jinjing Zhong, Ke Jiang, Zhihui Li, Rixiang Gong, Jingqiang Zhu
OBJECTIVE: This study was performed to investigate the frequency and pattern as well as the predictive factors of skip metastasis (lateral cervical lymph node metastasis without central lymph node metastasis) in papillary thyroid carcinoma (PTC). METHODS: 450 PTC patients who received total thyroidectomy with central neck dissection(CND) combined with modified radical lateral neck dissection(LND) were divided into two groups: with or without skip metastases. The clinicopathological characteristics were statistically compared and analyzed, and univariate and multivariate analyses were performed to detect the risk factors of skip metastasis...
February 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28222967/clinical-implications-of-microscopic-extrathyroidal-extension-in-patients-with-papillary-thyroid-carcinoma
#4
Ji Su Park, Jae Won Chang, Lihua Liu, Seung-Nam Jung, Bon Seok Koo
BACKGROUND: Extrathyroidal extension (ETE) is a poor prognostic factor in papillary thyroid carcinoma (PTC). However, the impact of the degree of ETE, especially microscopic ETE, has not been well established. The purpose of present study was to compare differences in clinicopathological characteristics and clinical outcomes according to the presence or extent of ETE. METHODS: Data from 381 patients who underwent total thyroidectomy with/without lymph node (LN) dissection for PTC between 2004 and 2010 were analyzed...
February 17, 2017: Oral Oncology
https://www.readbyqxmd.com/read/28216937/renal-cell-carcinoma-atypical-metastasis-to-inguinal-lymph-nodes
#5
Qamar Saeed Chaudhry, Tanweer Ahmed Naveed Bhatty, Ziauddin Khan, Elsawi Medani Osman
Renal cell carcinoma (RCC) is a common tumor of the urinary tract. It is known to have variable presentations due to the extremely vascular nature of the organ. RCC are known to metastasize to lungs, bone, and brain commonly but atypical metastasis to various sites are reported in literature but as very rare pathology. We report a case of a 60-year-old female who presented with multiple inguinal and axillary lymph node enlargements which on excision biopsy showed metastatic RCC. RCC can present with synchronous metastatic deposits in the various organs...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28214213/the-relationship-between-brafv600e-nf-%C3%AE%C2%BAb-and-tgab-expression-in-papillary-thyroid-carcinoma
#6
Wei Li, Hui Ming, Danyang Sun, Wei Li, Dan Wang, Guizhi Zhang, Jian Tan
PURPOSE: The aim of this study was to investigate the potential link between thyroglobulin antibody (TgAb) titers and papillary thyroid carcinoma (PTC) aggressiveness. MATERIALS AND METHODS: This retrospective study included 122 patients who had undergone total thyroidectomy and neck central area lymph dissection followed by radioactive iodine (RAI) ablation for PTC between July 2012 and July 2014. The parameters included clinical characteristics of PTC, TgAb levels and tumor histopathological characteristics...
January 12, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28205384/cribriform-adenocarcinoma-of-the-minor-salivary-gland-arising-in-the-tonsil-with-metastasis-to-a-cervical-lymph-node-a-case-report-with-description-of-fine-needle-aspiration-cytology
#7
Alexa Pagano, Katie Dennis
Cribriform adenocarcinoma of minor salivary gland (CAMSG) is a rare tumor of the head and neck. We report a case of a 70-year-old female who presented with a 4-5-month history of a left neck mass. CT scan of the neck showed a left neck mass just inferior to the angle of the mandible and left tonsillar prominence. Fine-needle aspiration (FNA) of the neck mass showed epithelial groups with focal cribriform architecture. The cells had round to oval nuclei and fine chromatin. The background contained scattered lymphocytes...
February 16, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28204971/the-presence-of-cancerous-nodules-in-lymph-nodes-is-a-novel-indicator-of-distant-metastasis-and-poor-survival-in-patients-with-papillary-thyroid-carcinoma
#8
Ling Chen, Youzhi Zhu, Ke Zheng, Huihao Zhang, Hongkun Guo, Li Zhang, Kunlin Wu, Lingjun Kong, Weihong Ruan, Jianying Hu, Xin Zhang, Xiangjin Chen
PURPOSE: Several characteristics of lymph node metastasis (LNM) as predictors of the risk of recurrence or death were examined in patients with papillary thyroid carcinoma (PTC). The presence of cancerous nodules as a characteristic of LNMs in PTC has not yet been reported. The objective of this study was to evaluate the use of the cancerous nodules in the lymph node (CNLN) to determine the risk of distant metastasis and survival in patients with PTC. METHODS: This retrospective observational cohort study enrolled 1408 patients with pathologically confirmed PTC without initial distant metastasis who underwent thyroidectomy and neck dissection...
February 15, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28183787/prognostic-significance-of-diffuse-sclerosing-variant-papillary-thyroid-carcinoma-a-systematic-review-and-meta-analysis
#9
Huy Gia Vuong, Tetsuo Kondo, Thong Quang Pham, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh
OBJECTIVE: Diffuse sclerosing variant papillary thyroid carcinoma (DSVPTC) is an uncommon variant of papillary thyroid carcinoma (PTC). The biological behaviors and prognostic outcomes of this variant, however, are still controversial. The aim of this systematic review and meta-analysis is to investigate the prognostic significance and outcomes of DSVPTCs in comparison with classical PTCs (cPTCs). METHODS: An electronic search was performed in five libraries: PubMed, Scopus, ISI, World Health Organization Global Health Library (WHO GHL) and Virtual Health Library (VHL) in June 2016...
April 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28176151/frequent-braf-v600e-and-absence-of-tert-promoter-mutations-characterize-sporadic-pediatric-papillary-thyroid-carcinomas-in-japan
#10
Naoki Oishi, Tetsuo Kondo, Tadao Nakazawa, Kunio Mochizuki, Tomohiro Inoue, Kazunari Kasai, Ippei Tahara, Tomonori Yabuta, Mitsuyoshi Hirokawa, Akira Miyauchi, Ryohei Katoh
Pediatric papillary thyroid carcinoma (PTC) has unique features but requires further genetic investigation. Moreover, there has been increasing concern about the risk for pediatric PTC in Japan after the Fukushima accident. This study aims to evaluate the frequencies of BRAF and TERT promoter mutations and to examine their significance in non-radiation-associated pediatric PTCs in Japan. We enrolled 81 pediatric PTC patients aged ≤20 years. The control group included 91 adult PTCs from patients >20 years old...
February 7, 2017: Endocrine Pathology
https://www.readbyqxmd.com/read/28167464/high-frequency-ultrasound-features-and-pathological-characteristics-of-medullary-thyroid-carcinoma
#11
Hua Wang, Mengmeng Liu, Jianqiu Yang, Yimin Song
To study high-frequency ultrasound features and pathological characteristics of medullary thyroid carcinoma (medullary thyroid carcinoma, MTC) with the purpose to improve the diagnostic accuracy of this disease. The clinical data of 20 cases of patients with MTC confirmed by the clinical surgery were retrospectively analyzed. And the high-frequency ultrasound features were analyzed and compared with the pathological characteristics. There were 16 cases with tumor invasion into one side of the thyroid gland; 17 cases with tumor in the middle-upper pole of the thyroid gland...
November 2016: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28166397/the-utility-of-intraoperative-frozen-section-for-the-evaluation-of-microscopic-extrathyroidal-extension-in-papillary-thyroid-carcinoma
#12
Jong Chul Hong, Ji Won Seo, Ae Lan Jang, Sung Hwan Suh, Min Gyoung Pak, Seong Ho Han, Young Jin Park, Dong Kun Lee, Heon Soo Park, Myung Koo Kang
OBJECTIVES: This study is designed to evaluate the usefulness of intraoperative frozen section for the evaluation of microscopic extrathyroidal extension (ETE) in papillary thyroid carcinoma (PTC). DESIGN: Retrospective cohort study. SETTING: Dong-A University Medical Center, Busan, Korea PARTICIPANTS: Three hundred sixty-four patients who underwent thyroid surgery from January 2000 to December 2010, with PTC confined to one unilateral lobe as diagnosed using preoperative ultrasonography were enrolled...
February 6, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28166075/clinico-histopathological-survey-of-head-and-neck-cancer-at-tertiary-health-care-centre-dhulikhel-hospital
#13
S Dixit, C Upadhyaya, M Humagain, R Srii, V Marla
Background Head and neck is one of the most prevalent site for cancers along with lungs, cervix, breast and stomach. Hospital based cancer registries required for effective evaluation of diagnosis and management of cancer is inadequate in Nepal. Cancer registry system established by WHO is acquired by seven major hospitals in our country. However, data from tertiary health care centres like ours remain undocumented. Objective The objective of this study is to perform retrospective analysis of clinicohistopathological types of head and neck lesions which were eventually diagnosed as cancer in Dhulikel Hospital, a tertiary health care centre of Central East Nepal...
April 2016: Kathmandu University Medical Journal (KUMJ)
https://www.readbyqxmd.com/read/28164553/investigation-of-vegf-and-il-8-gene-polymorphisms-in-patients-with-differentiated-thyroid-cancer
#14
Ilhan Kilic, Sibel Guldiken, Tammam Sipahi, Orkide Palabiyik, Mustafa Akker, Ozlem Celik, Neslihan Soysal-Atile, Nermin Tuncbilek, Harun M Guven, A Sadi Gundogdu, Necdet Sut
BACKGROUND: Differentiated thyroid carcinomas (DTC) account for most of the thyroid cancers. The emergence of DTC may be affected by various predisposing genetic alterations and environmental factors The aim of this study was to investigate the role of VEGF C936T and IL-8 A251T gene polymorphisms in the pathogenesis and metastasis of differentiated thyroid cancer. METHODS: The study consisted of 101 patients DTC patients and 109 healthy controls. The parameters of the stage of cancer of the DTC patients at the time of diagnosis (TNM) were recorded...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28160142/patterns-predictive-factors-and-prognostic-impact-of-contralateral-lateral-lymph-node-metastasis-in-n1b-papillary-thyroid-carcinoma
#15
Seo Ki Kim, Inhye Park, Nayoon Hur, Musaed Rayzah, Jun Ho Lee, Jun-Ho Choe, Jung-Han Kim, Jee Soo Kim
BACKGROUND: Although the incidence among patients with bilateral lateral lymph node metastasis (LLNM) in N1b papillary thyroid carcinoma (PTC) is reported to be as high as 40%, only a few reports have addressed the characteristics of contralateral LLNM. Therefore, this study aimed to investigate the characteristics of patients with contralateral LLNM in N1b PTC. METHODS: This study retrospectively reviewed 834 patients with N1b PTC who underwent modified radical neck dissection between January 1997 and June 2015...
February 3, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28156153/should-multifocal-papillary-thyroid-carcinomas-classified-as-t1a-having-the-sum-of-tumor-diameters-1-2-centimeter-be-reclassified-as-t1b
#16
Abbas Ali Tam, Didem Ozdemir, Berna Evranos Ogmen, Sevgul Fakı, Ersin Gurkan Dumlu, Aylin Kılıc Yazgan, Reyhan Ersoy, Bekir Cakır
OBJECTIVE: Considering the diameter of the largest tumor while determining T stage in multifocal papillary thyroid microcarcinomas (PTMC) might cause underestimation of tumoral stage. We aimed to investigate the effect of total tumor diameter (TTD) on TNM classification in multifocal T1a PTMCs. METHODS: T1 tumors were grouped as T1a and T1b according to 7th TNM edition. For patients with multifocal T1a, TTD (the sum of the maximal diameter of each foci) was calculated and these patients were further subgrouped as TTD ≤1 cm and TTD 1-2 cm...
February 3, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28149805/radioguided-sentinel-lymph-node-biopsy-in-patients-with-papillary-thyroid-carcinoma
#17
Mattia Portinari, Paolo Carcoforo
BACKGROUND: The ATA guidelines do not recommend prophylactic central compartment neck dissection in patients with T1-T2 papillary thyroid carcinoma (PTC) with no clinical evidence of lymph node metastasis, however patients' staging is recommended. Lymph node metastasis may be present also in small PTC, but preoperative ultrasound identifies suspicious cervical lymphadenopathy in 20-30% of patients. The role of sentinel lymph node biopsy (SLNB) remain open to debate. It has been shown that the identification rate of SLN in PTC patients is improved using a radiotracer compared to a dye technique...
December 2016: Gland Surgery
https://www.readbyqxmd.com/read/28133244/-a-case-of-minimal-thyroid-carcinoma-diagnosed-by-a-solitary-pulmonary-metastasis
#18
Hiroshi Kawai, Ryoma Sugimoto, Norichika Iga, Hirokuni Ikeda, Ryosuke Yoshida, Naohisa Waki, Masahiro Ishizaki, Hideyuki Nishi, Kazuki Yamashita
We report a case of minimal thyroid carcinoma diagnosed by a solitary pulmonary metastasis. A 70's man visited a medical practitioner because of chest discomfort, and there was an abnormality on the chest X-ray. Chest computed tomography(CT) showed a nodule in the right middle lobe of the lung. Positron emission tomography with 18-fluorodeoxyglucose(FDG)-PET revealed increased FDG uptake in that tumor, but did not reveal any other lesion. The tumor was clinically suspected to be a carcinoid tumor, primary lung cancer, metastatic lung cancer, or a benign tumor...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28126748/improved-diagnostic-accuracy-using-arterial-phase-ct-for-lateral-cervical-lymph-node-metastasis-from-papillary-thyroid-cancer
#19
J E Park, J H Lee, K H Ryu, H S Park, M S Chung, H W Kim, Y J Choi, J H Baek
BACKGROUND AND PURPOSE: Contrast-enhanced CT protocols for papillary thyroid cancer are yet to be optimized. Our aim was to compare the diagnostic accuracy of arterial phase CT and delayed-phase CT protocols for lateral cervical lymph node metastasis from papillary thyroid carcinoma by using the lymph node tissue attenuation. MATERIALS AND METHODS: This retrospective study included 327 lateral cervical lymph nodes (177 metastatic and 150 benign) from 131 patients with papillary thyroid carcinoma (107 initially diagnosed and 24 recurrences)...
January 26, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28125451/clinical-and-morphologic-features-of-etv6-ntrk3-translocated-papillary-thyroid-carcinoma-in-an-adult-population-without-radiation-exposure
#20
Raja R Seethala, Simion I Chiosea, Cheng Z Liu, Marina Nikiforova, Yuri E Nikiforov
The ETV6-NTRK3 translocation characterizes a subset of radiation associated and pediatric papillary thyroid carcinomas (PTCs). We now describe the clinicopathologic features of ETV6-NTRK3 translocated PTC in an adult population without radiation exposure. Twelve cases were identified by next-generation sequencing (ThyroSeq version 2). The mean patient age was 37 years with a female predilection (10:2). Preoperative fine needle aspiration was performed on 6 patients of which 4 were classified as "malignant," whereas 2 were classified as "follicular lesion of undetermined significance...
January 25, 2017: American Journal of Surgical Pathology
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