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Lymph node metastasis thyroid carcinoma

Tongtong Liu, Xifeng Ge, Jinhua Yu, Yi Guo, Yuanyuan Wang, Wenping Wang, Ligang Cui
PURPOSE: B-mode ultrasound (B-US) and strain elastography ultrasound (SE-US) images have a potential to distinguish thyroid tumor with different lymph node (LN) status. The purpose of our study is to investigate whether the application of multi-modality images including B-US and SE-US can improve the discriminability of thyroid tumor with LN metastasis based on a radiomics approach. METHODS: Ultrasound (US) images including B-US and SE-US images of 75 papillary thyroid carcinoma (PTC) cases were retrospectively collected...
June 21, 2018: International Journal of Computer Assisted Radiology and Surgery
Li Li, Yi Li, Jun Zhang, Qiuji Wu, Haijun Yu, Zheng Li, Conghua Xie, Yunfeng Zhou, Yahua Zhong
Nasopharyngeal carcinoma (NPC) are characterized by distinct lymph node metastasis patterns. In order to minimize cervical lymph node irradiation volume, 379 NPC patients with metastatic cervical lymph nodes were eligible for geographic mapping. All lymph nodes were mapped into simulation computed tomography images of a template lymph node negative patient. The proportions of retropharyngeal lymph nodes (RLNs), Level Ib, II, III, IV, Va, Vb and supraclavicular (SCV) lymph nodes were 6.9%, 0.5%, 55.25%, 20.4%, 8...
June 5, 2018: Oncotarget
Hidenori Suzuki, Yusuke Koide, Nobuhiro Hanai, Daisuke Nishikawa, Shintaro Beppu, Shinji Mikami, Yasuhisa Hasegawa
We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition...
June 1, 2018: Oncotarget
Erjie Xia, Yinghao Wang, Adheesh Bhandari, Jizhao Niu, Fan Yang, Zhihan Yao, Ouchen Wang
Thyroid cancer is the most common malignancy of the endocrine organs. In order to further understand the tumorigenesis and progression of papillary thyroid carcinoma (PTC), the present study performed whole transcriptome sequence analysis. It was found that Cbp/p300-interacting transactivators with glutamic acid [E] and aspartic acid [D]-rich C-terminal domain 1 (CITED1) was a novel potential PTC-associated gene in thyroid cancer. The expression level and clinicopathological features of CITED1 were then assessed in The Cancer Genome Atlas (TCGA) database...
July 2018: Oncology Letters
T Zhang, Y Qu, L He, L Shao, D L Zhang, C Z Lü, P Zhang, H Zhang
Objective: To investigate the risk factors and preoperative evaluation of lymph nodes posterior to right recurrent laryngeal nerve (LN-prRLN) metastasis in papillary thyroid carcinoma (PTC). Methods: Clinical data of 301 patients with right or double lobes who underwent surgery between August 2015 and October 2016 in the Department of Thyroid Surgery, the First Hospital of China Medical University, were retrospectively analyzed. The relationships between LN-prRLN metastasis and clinical pathology data and other factors were analyzed...
June 12, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Jianhua Feng, Fei Shen, Wensong Cai, Xiaoxiong Gan, Xingyan Deng, Bo Xu
BACKGROUND: Patients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients <55 years of age with these variants is still unclear. We aim to investigate the clinicopathological features and survival of these variants in the age group <55 years. METHODS: All adult patients (<55 years old) with DSV, TCV and conventional PTC (CPTC) came from the Surveillance, Epidemiology, and End Results program (1988-2013)...
June 16, 2018: Endocrine
Yasemin Ucal, Murat Eravci, Fatma Tokat, Mete Duren, Umit Ince, Aysel Ozpinar
Introduction: Fine Needle Aspiration Biopsy (FNAB) allows the cytological differentiation of benign and malignant thyroid nodules. However, the method itself is not adequate in determining some cases. For example, the diagnosis of Follicular Variant Papillary Thyroid Carcinoma (FV-PTC) can be challenging. In the current study we investigate the protein profiles of FV-PTC and classical variant PTC (CV-PTC) with no lymph node metastasis and compare it with benign thyroid tissue. Method: We used CV-PTC (n = 6), FV-PTC (n = 6) and benign thyroid tissues (n = 6) to prepare tissue lysates...
December 2017: EuPA Open Proteomics
Quan Li, Wen-Xu Jin, Yi-Xiang Jin, Zhou-Ci Zheng, Xiao-Fen Zhou, Qing-Xuan Wang, Dan-Rong Ye, Yi-Han Sun, Xiao-Hua Zhang, Ou-Chen Wang, En-Dong Chen, Ye-Feng Cai
Aim: To investigate the clinical effects of MUC1 on papillary thyroid cancer (PTC) and explore the relationship between MUC1 expression and BRAF mutation. Methods: The data of 69 patients subjected to fine-needle aspiration biopsy in our hospital and 486 patient data downloaded from The Cancer Genome Atlas (TCGA) database were used. Univariate and multivariate analyses were performed. Results: The results on the 486 patients recorded in the TCGA indicated that high MUC1 expression was independently related to BRAF mutation, lymph node metastasis (LNM), and unifocal type...
2018: Cancer Management and Research
Eyun Song, Min Ji Jeon, Hye-Seon Oh, Minkyu Han, Yu-Mi Lee, Tae Yong Kim, Ki-Wook Chung, Won Bae Kim, Young-Kee Shong, Dong Eun Song, Won Gu Kim
OBJECTIVE: Evidence for unfavorable outcomes of each type of aggressive variant papillary thyroid carcinoma (AV-PTC) is not clear because most previous studies are focused on tall cell variant (TCV) and did not control for other major confounding factors contributing to clinical outcomes. DESIGN: Retrospective cohort study. METHODS: This study included 763 patients with classical PTC (cPTC) and 144 with AV-PTC, including TCV, columnar cell variant (CCV), and hobnail variants...
June 6, 2018: European Journal of Endocrinology
Sabin Filimon, Richard J Payne, Martin J Black, Michael P Hier, Alex M Mlynarek, Veronique-Isabelle Forest, Michael Tamilia
OBJECTIVE: Medullary thyroid carcinoma (MTC) is a rare thyroid malignancy originating from parafollicular C-cells with the potential for aggressive behavior. The extent of lymph node (LN) dissection at the time of surgery is controversial, with different schools of thought prevailing. Some systematically perform LN dissections, whereas others base their decision on radiologic evidence of disease and some with the assistance of pre-operative calcitonin (CT) levels. METHODS: We retrospectively assessed the correlation between pre-operative CT levels and clinico-pathologic factors among 42 patients with MTC between 1994 and 2015...
May 2018: Endocrine Practice
Yunjun Wang, Qing Guan, Jun Xiang
INTRODUCTION: The status of central lymph node metastasis (CLNM) is crucial to determining the surgical strategies for papillary thyroid micro carcinoma (PTMC). The objective of the study was to establish a nomogram to predict the possibility of CLNM in PTMC patients. METHODS: A total of 8668 PTMC patients who underwent total thyroidectomy or lobectomy with central lymph node dissection (CLND) from 2006 to 2016 were retrospectively retrieved. Univariate and multivariate analysis were performed to examine risk factors associated with CLNM...
May 24, 2018: International Journal of Surgery
Y M Chen, L Wei, X Lin, W J Zhang, J F Wu, G Xue
Objective: To explore the expression and clinical significance of nuclear factor erythroid-2 related factor 2 (Nrf2) and ERK sinal in papillary thyroid carcinoma (PTC). Method: PTC microassy were detected by immunohistochemical method (IHC). The expression of Nrf2, ERK₂ and p-ERK½ in PTC, para-carcimoma and normal thyroid tissue were detected by Western blot. The transcriptional level of Nrf2 mRNA in PTC, para-carcimoma and normal thyroid tissue were detected by real-time quantitative PCR (qPCR) method. Result: Nrf2, ERK₂, p-ERK½ protein were high expression in group of lymph node metastasis PTC and negative or weak positive expression in para-carcinoma tissue ( P <0...
June 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
A B Zhang, L F Liu, C Lu, Y Y Ma, Y B Dong, X Y Ge
Objective: To investigate the risk factors of central neck lymph node metastasis (CNLNM) in cN0 papillary thyroid carcinoma. Method: Retrospective analysis of 114 patients with papillary thyroid carcinoma in stage of cN0 who underwent primary treatment. Collected the clinical and pathological data, used the univariate and multivariate analysis to investigate the risk factors of central neck lymph node metastasis and high volume central neck lymph node metastasis. Result: In the univariate analysis, age (48...
August 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Y J Pang, X H Chen, J Y Zhang, J L Gao
Objective: To discuss the diagnosis, treatment and prognosis of metastatic papillary thyroid carcinoma in cervical lymph nodal with occult primary sites. Method: The clinical data of 5 patients involved papillary thyroid carcinoma with cervical lymph nodal metastasis with occult primary sites from 2009 to 2015 were analyzed. Result: According to preoperation examinations, two of them only underwent neck lymph node resection and three patients underwent asubtotal or total thyroidectomy plus neck lymph node dissection...
July 5, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
S Zhang, X H Jiang
Objective: To investigate the clinical characteristics of the risk factors of papillary thyroid carcinoma in different ages of young patients (<45y)associated with carbon nanoparticles. Method: A retrospective statistics and analysis of 183 patients who were diagnosed and treated; carbon nanoparticles were injected into the thyroid during operation and at last the conventional pathological diagnosis were papillary thyroid carcinoma of all patients; to analysis the gender, tumor size, capsular invasion, lymph node metastasis, multifocality and other risk factors between the <25y and 25-<5y patients...
April 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
L Qiao, C Dong, N Zhang, B L Ma
Objective: To summarize the metastatic feature of lateral neck lymph node metastasis in papillary thyroid carcinoma. Method: Clinical and pathological data were collected from 301 patients who were first diagnosed as PTC in our hospital. These patients were divided into positive and negative status of lateral cervical lymph nodes and lymph node jump metastasis. Chi-square test and Logistic regression analysis were used to evaluate the relationship between lateral cervical lymph node status and clinicopathology...
April 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
J Zhang, K Yao, K L Li
Objective: To compare the effectiveness and safety between minimally invasive video-assisted thyroidectomy (MIVAT) and conventional thyroidectomy (CT) in the treatment of papillary thyroid carcinoma without lymph node metastasis, providing clinicians using video-assisted way to treat thyroid papillary carcinoma with a more reasonable basis. Method: According to the including and excluding criterion,we searched the published articles which compare the effectiveness of MIVAT and CT curing PTC in randomized controlled clinical trials...
September 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Y Xu, L Ma, G A Zhang, W Wang, R Y Zhang, S Hou, W Cui
Objective: To comprehensively evaluate the association between the positive expression rate of transforming growth factor beta 1 (TGF-β1) and papillary thyroid carcinoma (PTC) by using Meta-analysis. Method: Search the CNKI, Wan fang, VIP and PubMed database for accumulating papers studying on the relationship between the positive expression of TGF-β1 and PTC in Chinese and English. Revman 5.3 was used to analyze the included trials. Result: A total of 6 studies comprising 617 samples was included in the meta-analysis...
September 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Yujie Zhang, Jing Yang, Mingfang Zhang, Zhaowei Meng, Wenjing Song, Long Yang, Liming Li, Dan Wang, Tao Shi
RATIONALE: Thyroid follicular carcinoma-like renal tumor (TFCLRT) is a rare primary renal epithelial tumor that was first reported in 2006. We report a case diagnosed of TFCLRT by us to observe the pathological feature and analyze comparatively the clinical and pathologic characteristics with all cases of reviewed literatures. PATIENT CONCERNS: A 54-year-old female patient had the urinary frequency with the symptom of right flank pain with a history of more than half a year of hypertension and received uterine fibroid resection 12 years ago...
May 2018: Medicine (Baltimore)
Jose Higino Steck, Elaine Stabenow, Gustavo Baldove Bettoni, Samuel Steck, Claudio Roberto Cernea
OBJECTIVES: The objectives of this study were to evaluate the following: 1) the accuracy of sentinel lymph node mapping (SLNM) in detecting metastasis in papillary thyroid carcinoma (PTC), and 2) if SLNM could modify the American Joint Committee on Cancer (AJCC) staging of previous cN0 PTC patients. SUBJECTS AND METHODS: Forty SLNM were performed prospectively in 38 consecutive cN0 PTC patients, with total thyroidectomy and elective compartment neck dissection (CND)...
May 17, 2018: Archives of Endocrinology and Metabolism
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