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Lymph node metastasis thyroid carcinoma

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https://www.readbyqxmd.com/read/29048684/mir-146a-and-mir-146b-in-the-diagnosis-and-prognosis-of-papillary-thyroid-carcinoma
#1
Zhenwei Qiu, Hai Li, Jianwei Wang, Chongbing Sun
The present study investigated the relationship between the expression of miR-146a and miR‑146b with the occurrence and prognosis of papillary thyroid carcinoma. Experiments in vitro were also used to explore the effect of the knocked down expression of the miRNAs on growth and migration of papillary thyroid carcinoma cells. A total of 73 patients with papillary thyroid carcinoma admitted to Yidu Central Hospital of Weifang from September 2013 to September 2015 were enrolled in the study. Carcinoma samples were obtained from each patient, and adjacent tissues were used as control samples to determine expression levels of miR-146a and miR146b by semi-quantitative RT-PCR...
September 25, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29032663/number-of-metastatic-lymph-nodes-and-ratio-of-metastatic-lymph-nodes-to-total-number-of-retrieved-lymph-nodes-are-risk-factors-for-recurrence-in-patients-with-clinically-node-negative-papillary-thyroid-carcinoma
#2
Chuan-Ming Zheng, Yong Bae Ji, Chang Myeon Song, Ming-Hua Ge, Kyung Tae
Objectives: The number of metastatic lymph nodes (LNs) and the ratio between the number of metastatic LNs and the total number of retrieved LNs (the LN ratio [LNR]) have been proposed as risk factors for recurrence of papillary thyroid carcinoma (PTC). However, the significance of the number of LNs and the LNR in patients with clinically node negative PTC has not been clearly determined. The purpose of this study is to evaluate their significance. Methods: We retrospectively analyzed 382 patients with PTC who had undergone total thyroidectomy with prophylactic central neck dissection (CND) between January 2000 and December 2010...
October 17, 2017: Clinical and Experimental Otorhinolaryngology
https://www.readbyqxmd.com/read/29022644/assessment-of-risk-factors-in-metastatic-recurrent-tall-cell-variant-of-papillary-thyroid-carcinoma
#3
Kursat Okuyucu, Engin Alagoz, Semra Ince, Nuri Arslan
INTRODUCTION: Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor. A great majority of the cases live a disease-free life with quite favorable prognosis. There are lots of variants of PTC and a few of them exhibit aggressive behaviour. Typical example is the tall cell variant (TCV). Patients experience a greater incidence of recurrence, nodal and extranodal metastases, tumor associated mortality than other variants of PTC. Studies related to TCV almost always compared it with its patient population of PTC according to risk factors and clinicopathologic features...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28994272/programmed-death-ligand-1-expression-and-its-correlation-with-lymph-node-metastasis-in-papillary-thyroid-carcinoma
#4
Hyo Jung An, Gyung Hyuck Ko, Jeong-Hee Lee, Jong Sil Lee, Dong Chul Kim, Jung Wook Yang, Min Hye Kim, Jin Pyeong Kim, Eun Jung Jung, Dae Hyun Song
Background: The immunotherapeutic role of programmed death-ligand 1 (PD-L1) in life expectancy in many cancers has been highlighted. However, data regarding PD-L1 expression in papillary thyroid carcinoma (PTC) are limited. In this study, we describe the PD-L1 and programmed cell death protein 1 (PD-1) expressions in PTC and analyze their correlation with lymph node (LN) metastasis. Materials and Methods: Clinicopathological data were obtained from 116 patients with PTC who were treated in Gyeongsang National University Hospital, Jinju, Korea in 2009...
October 3, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28982849/predictive-value-of-sphingosine-kinase-1-expression-in-papillary-thyroid-carcinoma
#5
Sung-Im Do, Hyun-Soo Kim, Kyungeun Kim, Hyunjoo Lee, In-Gu Do, Dong-Hoon Kim, Seoung Wan Chae, Jin Hee Sohn
BACKGROUND/AIM: Sphingolipid metabolites are emerging as key signaling molecules in cancer. Sphingosine kinase 1 is up-regulated in many different types of human malignancies and plays a crucial role in cancer development and progression. The utility of sphingosine kinase 1 to act as a predictive biomarker in thyroid cancer remains unclear. MATERIALS AND METHODS: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28979140/predictive-factors-and-prognosis-for-recurrent-laryngeal-nerve-invasion-in-papillary-thyroid-carcinoma
#6
Wenjie Chen, Jianyong Lei, Jiaying You, Yali Lei, Zhihui Li, Rixiang Gong, Huairong Tang, Jingqiang Zhu
BACKGROUND: Recurrent laryngeal nerve (RLN) invasion in papillary thyroid carcinoma (PTC) is one of the main predictors of poor prognosis. The present study investigated the risk factors for RLN invasion in PTC patients. METHODS: A total of 3,236 patients who received thyroidectomy due to PTC in Thyroid and Parathyroid Surgery Center of West China Hospital of Sichuan University were reviewed. Demographics and clinical factors, imaging examination (ultrasonography) characteristics, surgical details, postoperative pathological details, recurrence, and postoperative complications were recorded...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28979135/intraoperative-measurement-of-thyroglobulin-in-lymph-node-aspirates-for-the-detection-of-metastatic-papillary-thyroid-carcinoma
#7
Yizeng Wang, Yuanchao Liu, Xiaoning Wang, Xin Li, Ruoyu Jiang, Xianghui He
BACKGROUND: Among patients with papillary thyroid carcinoma (PTC), 30%-80% have cervical lymph node (LN) metastases, which are most commonly located in the central compartment. However, preoperative ultrasonography identifies malignant central compartment LNs in only 20%-30% of cases. We aimed to evaluate the diagnostic value of intraoperative thyroglobulin (Tg) measurement in fine-needle aspirates (FNA-Tg) of suspicious metastatic LNs. METHODS: In total, 75 patients (75 LNs) with PTC or suspected PTC were enrolled in this study...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28975988/risk-factors-for-predicting-central-lymph-node-metastasis-in-papillary-thyroid-microcarcinoma-cn0-a-study-of-273-resections
#8
M Li, X-Y Zhu, J Lv, K Lu, M-P Shen, Z-L Xu, Z-S Wu
OBJECTIVE: The role of routine central lymph node dissection (CLND) for clinically central lymph node negative (CN0) papillary thyroid microcarcinoma (PTMC) remains uncertain. We aim to determine the predictive factors for central lymph node metastasis (CLNM) in papillary thyroid microcarcinoma. PATIENTS AND METHODS: A total of 273 patients diagnosed with clinically central lymph node negative PTMC from 2014 to 2016 were included. The predictive risk factors for CLNM were analyzed with respect to age, sex, tumor size, tumor multifocal, lymphadenectasis of lateral neck, capsular invasion, extra capsular spread (ECS), coexistence of chronic lymphocytic thyroiditis (Hashimoto thyroiditis, HT) and nodular goiter (NG), BRAFV600E mutation and subtype of papillary thyroid carcinoma (PTC)...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28973144/risk-factors-associated-with-reoperation-and-disease-specific-mortality-in-patients-with-medullary-thyroid-carcinoma
#9
Eric J Kuo, Shonan Sho, Ning Li, Kyle A Zanocco, Michael W Yeh, Masha J Livhits
Importance: The association of initial neck dissection with recurrence in medullary thyroid carcinoma (MTC) has not been evaluated on a population level to date. Objective: To elucidate risk factors associated with reoperation in MTC and disease-specific mortality. Design, Setting, and Participants: A retrospective analysis was performed of hospital data obtained from the California Cancer Registry and the Office of Statewide Health Planning and Development from January 1, 1999, through December 31, 2012...
September 27, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28955678/axillary-lymph-node-metastasis-in-medullary-thyroid-carcinoma-a-case-report
#10
Seyed Ziaeddin Rasihashemi, Ramin Azhough, Ali Ramouz
INTRODUCTION: Medullary thyroid cancer (MTC) is an uncommon neoplasm originating from parafollicular C cells. Distant metastasis in MTC, such as axillary node involvement, is extremely rare. CASE REPORT: The present study describes a known case of MTC with axillary lymph node metastasis in a 31-year-old woman. In 2010, she underwent total thyroidectomy and right-sided modified radical neck dissection. In May 2015, she was referred with a 3-month history of a mass in the left axilla...
September 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28947799/concomitant-high-expression-of-er%C3%AE-36-egfr-and-her2-is-associated-with-aggressive-behaviors-of-papillary-thyroid-carcinomas
#11
Yu-Jie Dai, Yi-Bo Qiu, Rong Jiang, Man Xu, Le Zhao, George G Chen, Zhi-Min Liu
ERα, ERβ, PR, ERα36, EGFR and HER2 mRNA and protein expression in papillary thyroid carcinoma (PTC) were examined by real time RT-PCR and immunohistochemical staining. The mRNA and protein expression of ERα and PR were gradually increased and those of ERβ were gradually decreased from normal thyroid tissues to nodular hyperplasias (P < 0.05) and to PTCs (P < 0.05). However, the mRNA and protein expression of ERα36, EGFR and HER2 were only significantly increased in PTCs when compared with those in normal thyroid tissues (P < 0...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28942234/second-generation-of-familial-nonmedullary-thyroid-carcinoma-a-meta-analysis-on-the-clinicopathologic-features-and-prognosis
#12
REVIEW
Yi-Mei Zhou, Han Luo, Ju-Xiang Gou, Wan-Jun Zhao, Wen-Yu Dai, Jingqiang Zhu, Zhi-Hui Li
Whether the second generation of parent/offspring type familial nonmedullary thyroid carcinoma (FNMTC) is more aggressive and has worse prognosis than their first generation counterpart is controversial. To evaluate the clinicopathologic features and prognosis of the second generation via a comparison between the two groups, We searched three databases (PubMed, EMBASE and the Cochrane library) to review studies published before November 25, 2016. All original studies comparing the clinicopathologic features and prognosis in the first generation of parent/offspring type FNMTC with its second generation counterpart were included...
September 12, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28919092/cervical-soft-tissue-recurrence-of-differentiated-thyroid-carcinoma-after-thyroidectomy-indicates-a-poor-prognosis
#13
Luying Gao, Yuxin Jiang, Zhiyong Liang, Lei Zhang, Xinxin Mao, Xiao Yang, Ying Wang, Jingzhu Xu, Ruyu Liu, Shenling Zhu, Ruina Zhao, Xingjian Lai, Xiaoyan Zhang, Bo Zhang
BACKGROUND: We investigated cervical soft tissue recurrence of differentiated thyroid carcinoma (DTC) after thyroidectomy, and these lesions exhibited no evidence that they were lymph nodes (LNs). METHODS: Between January 2012 and April 2016, consecutive 6308 patients underwent thyroid surgery for DTC at our center. Among them, we encountered 21 patients with recurrent cervical soft tissue lesions, none of whom had previously undergone fine needle aspiration biopsy (FNAB)...
September 14, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28913696/clinicopathological-risk-factors-for-distant-metastasis-in-differentiated-thyroid-carcinoma-a-meta-analysis
#14
REVIEW
Huy Gia Vuong, Uyen N P Duong, Thong Quang Pham, Hung Minh Tran, Naoki Oishi, Kunio Mochizuki, Tadao Nakazawa, Lewis Hassell, Ryohei Katoh, Tetsuo Kondo
INTRODUCTION: Distant metastasis (DM) is not a frequent event in differentiated thyroid carcinoma (DTC) but has an adverse impact on mortality of patients with DTC. In the current study, we aimed to conduct a comprehensive systematic review and meta-analysis to investigate the risk factors for DM in DTCs and for each histological subtype. METHODS: Five electronic databases were searched from inception to December 2016 for relevant articles. Pooled odd ratios and 95% confidence interval were calculated using random-effect model...
September 14, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28911147/kif5b-ret-rearrangement-in-a-carcinoma-of-the-thyroid-gland-a-case-report-of-a-fatal-disease
#15
David Viola, Carlotta Giani, Salvatore Mazzeo, Clara Ugolini, Raffaele Ciampi, Eleonora Molinaro, Laura Agate, Nicla Borrelli, Antonio Chella, Gabriella Fontanini, Fulvio Basolo, Rossella Elisei
Background: The diffuse sclerosing variant of papillary thyroid cancer (DSV-PTC) is a rare variant of papillary thyroid cancer (PTC) with different clinicopathological features compared with conventional PTC. Case: An advanced DSV-PTC was diagnosed in a 39-year-old man. The radioiodine posttherapeutic whole-body-scan showed only an uptake in the central neck, whereas the computerized tomography showed multiple latero-cervical and mediastinum lymph node metastases, a single and spiculated lung lesion and multiple bilateral cerebellum metastases...
September 1, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28906015/influence-of-coexistent-hashimoto-s-thyroiditis-on-the-extent-of-cervical-lymph-node-dissection-and-prognosis-in-papillary-thyroid-carcinoma
#16
Eyun Song, Min Ji Jeon, Suyeon Park, Mijin Kim, Hye-Seon Oh, Dong Eun Song, Won Gu Kim, Won Bae Kim, Young Kee Shong, Tae Yong Kim
OBJECTIVE: Previous studies did not focus on the differences in the extent of cervical lymph node (LN) dissection according to coexistent Hashimoto's thyroiditis (HT) in patients with papillary thyroid carcinoma (PTC) and its clinical impact. We aimed to determine whether extensive cervical LN dissection is responsible for favorable clinical outcomes in PTC patients with HT and whether coexistence of HT itself has an independent protective effect regardless of LN status. DESIGN: Retrospective cohort study PATIENTS: 1,369 patients with PTC who underwent total thyroidectomy with central compartment neck dissection...
September 14, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28901320/thyroid-carcinoma-in-children-and-adolescents-clinical-characteristics-and-follow-up-from-two-centers
#17
Jing-Jing Pan, Li Zhao, Rui Cheng, Yang Yang, Yu-Hua Hu
AIM OF STUDY: The aim of this study was to analyze the clinical features and outcomes of thyroid carcinoma (TC) in children and adolescent population treated in our institution. MATERIALS AND METHODS: We gathered 43 TC patients 18 years of age or under initial diagnosed between 2009 and 2010 from two hospitals. Patient's clinical characteristics, laboratory tests, and outcomes were collected and analyzed. RESULTS: (1) The incidence of TC is higher in women (2...
2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28898463/update-on-the-potential-significance-of-psammoma-bodies-in-lung-adenocarcinoma-from-a-modern-aspect
#18
Akio Miyake, Koji Okudela, Mai Matsumura, Hideaki Mitsui, Hiromasa Arai, Shigeaki Umeda, Shoji Yamanaka, Yoshihiro Ishikawa, Michihiko Tajiri, Kenichi Ohashi
AIMS: Psammoma bodies are concentrically lamellated microscopic structures of calcium. They are commonly observed in papillary carcinomas of the thyroid gland and serous papillary adenocarcinomas of the ovary, but are also occasionally detected in lung adenocarcinomas. Only one study has ever been published in 1972, which systematically described the significance of psammoma bodies in lung adenocarcinomas. We herein updated the significance of psammoma bodies in lung adenocarcinomas from a modern aspect...
September 12, 2017: Histopathology
https://www.readbyqxmd.com/read/28895542/selective-sentinel-lymph-node-biopsy-in-papillary-thyroid-carcinoma-in-patients-with-no-preoperative-evidence-of-lymph-node-metastasis
#19
Óscar González, Carles Zafon, Enric Caubet, Amparo García-Burillo, Xavier Serres, José Manuel Fort, Jordi Mesa, Joan Castell, Isabel Roca, Santiago Ramón Y Cajal, Carmela Iglesias
INTRODUCTION: Lymphadenectomy is recommended during surgery for papillary thyroid carcinoma when there is evidence of cervical lymph node metastasis (therapeutic) or in high-risk patients (prophylactic) such as those with T3 and T4 tumors of the TNM classification. Selective sentinel lymph node biopsy may improve preoperative diagnosis of nodal metastases. OBJECTIVE: To analyze the results of selective sentinel lymph node biopsy in a group of patients with papillary thyroid carcinoma and no evidence of nodal involvement before surgery...
October 2017: Endocrinología, diabetes y nutrición
https://www.readbyqxmd.com/read/28892908/cytological-diagnosis-of-an-uncommon-high-grade-malignant-thyroid-tumour-a-case-report
#20
Ruchi Nagpal, Manju Kaushal, Sawan Kumar
Anaplastic Thyroid Carcinoma (ATC) is a relatively uncommon highly malignant tumour originating from the follicular cells of thyroid gland having poor prognosis. It accounts for 2% to 5% of all thyroid carcinomas and patients typically present with a rapidly growing anterior neck mass with aggressive symptoms. A 53-year-old male presented with diffuse neck swelling measuring 8x6 cm and right cervical lymph node measuring 2x2 cm since one month which was associated with dyspepsia and dyspnoea. Ultrasound and Contrast Enhanced Computed Tomography (CECT) neck revealed enlarged right lobe of thyroid and multiple enlarged cervical lymph nodes with soft tissue density nodules in bilateral lungs...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
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