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Mri and prostate biopsy

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https://www.readbyqxmd.com/read/28333017/effect-of-prostate-magnetic-resonance-imaging-ultrasound-fusion-guided-biopsy-on-radiation-treatment-recommendations
#1
Aaron Reed, Luca F Valle, Uma Shankavaram, Andra Krauze, Aradhana Kaushal, Erica Schott, Theresa Cooley-Zgela, Bradford Wood, Peter Pinto, Peter Choyke, Baris Turkbey, Deborah E Citrin
PURPOSE: Targeted magnetic resonance imaging (MRI)/ultrasound fusion prostate biopsy (MRI-Bx) has recently been compared with the standard of care extended sextant ultrasound-guided prostate biopsy (SOC-Bx), with the former associated with an increased rate of detection of clinically significant prostate cancer. The present study sought to determine the influence of MRI-Bx on radiation therapy and androgen deprivation therapy (ADT) recommendations. METHODS AND MATERIALS: All patients who had received radiation treatment and had undergone SOC-Bx and MRI-Bx at our institution were included...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28322902/negative-multi-parametric-mri-of-the-prostate-predicts-absence-of-clinically-significant-prostate-cancer-on-12-core-template-prostate-biopsy
#2
Amanda J Lu, Jamil S Syed, Kevin A Nguyen, Cayce B Nawaf, James Rosoff, Michael Spektor, Angelique Levi, Peter A Humphrey, Jeffrey C Weinreb, Peter G Schulam, Preston C Sprenkle
OBJECTIVE: To determine the negative predictive value of multiparametric-MRI (mpMRI), we evaluated the frequency of prostate cancer detection by 12-core template mapping biopsy in men whose mpMRI showed no suspicious regions. METHODS: 670 patients underwent mpMRI followed by transrectal ultrasound-(TRUS) guided systematic prostate biopsy from December 2012 to June 2016. Of this cohort, 100 patients had a negative mpMRI. mpMRI imaging sequences included T2-weighted, diffusion-weighted imaging, and dynamic contrast enhancement sequences...
March 16, 2017: Urology
https://www.readbyqxmd.com/read/28306604/role-of-mri-in-low-risk-prostate-cancer-finding-the-wolf-in-sheep-s-clothing-or-the-sheep-in-wolf-s-clothing
#3
Ivo G Schoots, Caroline M Moore, Olivier Rouvière
PURPOSE OF REVIEW: In men on active surveillance for localized prostate cancer, MRI and MRI-targeted biopsies can be used prior to confirmatory or surveillance biopsy, to detect individuals with high-grade cancer (the wolf in sheep's clothing). However, some men will have low-risk disease despite adverse MRI findings (the sheep in wolf's clothing). We review the value addition of MRI-targeted biopsies in comparison to systematic transrectal ultrasound-guided biopsies, using pathological reclassification as an end-point...
March 16, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28295933/high-concordance-of-findings-obtained-from-in-gantry-transgluteal-mri-and-trus-guided-biopsy-as-compared-to-prostatectomy-specimens
#4
Stefan Steurer, Sebastian Dwertmann Rico, Ronald Simon, Sarah Minner, Maria Christina Tsourlakis, Till Krech, Christina Koop, Markus Graefen, Hans Heinzer, Meike Adam, Hartwig Huland, Thorsten Schlomm, Guido Sauter, Agron Lumiani
OBJECTIVES: To determine the utility of our transgluteal MRI-guided prostate biopsy approach. PATIENTS AND METHODS: 960 biopsy series taken within the period of one year were evaluated including 301 MRI-guided and 659 TRUS-guided biopsies. RESULTS: The positivity rate and the fraction of high-grade cancers were significantly higher in MRI-guided than in TRUS biopsies. 65.4% of 301 MRI-guided and 57.2% of 659 TRUS biopsies contained cancer (p=0...
March 13, 2017: BJU International
https://www.readbyqxmd.com/read/28293720/pathologic-correlation-of-transperineal-in-bore-3-tesla-magnetic-resonance-imaging-guided-prostate-biopsy-samples-with-radical-prostatectomy-specimen
#5
Erik Velez, Andriy Fedorov, Kemal Tuncali, Olutayo Olubiyi, Christopher B Allard, Adam S Kibel, Clare M Tempany
PURPOSE: To determine the accuracy of in-bore transperineal 3-Tesla (T) magnetic resonance (MR) imaging-guided prostate biopsies for predicting final Gleason grades in patients who subsequently underwent radical prostatectomy (RP). METHODS: A retrospective review of men who underwent transperineal MR imaging-guided prostate biopsy (tpMRGB) with subsequent radical prostatectomy within 1 year was conducted from 2010 to 2015. All patients underwent a baseline 3-T multiparametric MRI (mpMRI) with endorectal coil and were selected for biopsy based on MR findings of a suspicious prostate lesion and high degree of clinical suspicion for cancer...
March 14, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28279782/a-prospective-study-investigating-the-impact-of-multiparametric-mri-in-biopsy-na%C3%A3-ve-patients-with-clinically-suspected-prostate-cancer-the-prokomb-study
#6
Alexander D J Baur, Thomas Henkel, Manfred Johannsen, Thomas Speck, Lothar Weißbach, Bernd Hamm, Frank König
BACKGROUND: Patients with suspected prostate cancer (PCa) undergo systematic transrectal ultrasound (TRUS)-guided biopsy of the prostate in order to verify or rule out PCa. However, TRUS-guided biopsy is error-prone resulting in underdetection of clinically significant cancers as well as diagnosis of clinically insignificant cancers. Multiparametric MRI (mpMRI) might improve this diagnostic pathway and help to avoid unnecessary biopsies. DESIGN AND METHODS: The PROKOMB (Prostata - Kooperatives MRT-Projekt Berlin) study is a prospective two-arm multicentre study designed to evaluate the potential role of mpMRI as a triage test before biopsy...
March 6, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28267899/-risk-stratification-based-on-magnetic-resonance-imaging-and-prostate-specific-antigen-density-may-reduce-unnecessary-follow-up-biopsy-procedures-in-men-on-active-surveillance-for-low-risk-prostate-cancer
#7
Arnout R Alberts, Monique J Roobol, Frank-Jan H Drost, Geert J van Leenders, Leonard P Bokhorst, Chris H Bangma, Ivo G Schoots
OBJECTIVES: To assess the value of risk-stratification based on magnetic resonance imaging (MRI) and prostate-specific antigen (PSA) density in reducing unnecessary biopsies without missing Gleason pattern 4 prostate cancer (PCa) in men on active surveillance. MATERIALS AND METHODS: A total of 210 men on active surveillance with GS 3+3 PCa received a first MRI and if indicated (PI-RADS ≥3) targeted biopsy (TBx) using MRI-TRUS fusion. The MRI was performed 3 months after diagnosis (group A: n=97), at confirmatory biopsy (group B: n=39) or at surveillance biopsy after ≥1 repeat TRUS-guided systematic biopsies (TRUS-Bx) (group C: n=74)...
March 7, 2017: BJU International
https://www.readbyqxmd.com/read/28267359/prostate-imaging-reporting-and-data-system-version-2-assessment-categories-and-pathologic-outcomes-in-patients-with-gleason-score-3-4-7-prostate-cancer-diagnosed-at-biopsy
#8
Christopher S Lim, Matthew D F McInnes, Trevor A Flood, Rodney H Breau, Christopher Morash, Rebecca E Thornhill, Nicola Schieda
OBJECTIVE: The purpose of this study is to assess associations between Prostate Imaging Reporting and Data System, version 2 (PI-RADSv2), categories and the presence of a tumor with a Gleason score (GS) of 4 + 3 = 7 or greater or the presence of extraprostatic extension (EPE) at radical prostatectomy (RP) in patients with a GS 3 + 4 = 7 tumor at biopsy. MATERIALS AND METHODS: A total of 81 men with GS 3 + 4 = 7 prostate cancer diagnosed by transrectal ultrasound-guided biopsy underwent multiparametric MRI and RP between 2012 and 2015...
March 7, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28267056/active-surveillance-for-low-risk-prostate-cancer
#9
Laurence Klotz
PURPOSE OF REVIEW: The approach of active surveillance for low-risk prostate cancer has evolved in many ways since its introduction 20 years ago. There is a great deal of ongoing research addressing the molecular genetics and clinical outcome of low-risk disease, the use of MRI and biomarkers, and the role of lifestyle and dietary modifications. The major developments in the field are reviewed in this article. RECENT FINDINGS: Low risk and many cases of low-intermediate risk prostate cancer are indolent, have little or no metastatic potential, and do not pose a threat to the patient in his lifetime...
March 4, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28258961/-in-bore-mri-guided-prostate-biopsy-using-an-endorectal-nonmagnetic-device-a-prospective-study-of-70-consecutive-patients
#10
Riccardo Schiavina, Valerio Vagnoni, Daniele D'Agostino, Marco Borghesi, Antonio Salvaggio, Marco Giampaoli, Cristian V Pultrone, Giacomo Saraceni, Caterina Gaudiano, Mario Vigo, Lorenzo Bianchi, Hussam Dababneh, Gaetano La Manna, Francesco Chessa, Daniele Romagnoli, Giuseppe Martorana, Eugenio Brunocilla, Angelo Porreca
INTRODUCTION: We investigated the diagnostic performance of in-bore endorectal magnetic resonance imaging-guided biopsy (MRI-GB) with a 1.5-T MRI scanner using a 32-channel coil in patients with suspected prostate cancer (PCa). PATIENTS AND METHODS: Seventy patients with ≥ 1 suspicious area found on the preliminary multiparametric MRI scan were enrolled. The index lesion was defined as the lesion with the greatest Prostate Imaging Reporting and Data System, version 2 (PIRADS-v2), score...
February 1, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28258910/-prevalence-and-diversity-of-management-of-prostate-cancer-patients-classified-as-low-risk-using-d-amico-group-or-cancer-of-the-prostate-risk-assessment-capra-score-a-french-multicenter-study
#11
P Léon, G Cancel-Tassin, N Koutlidis, J Calves, M Funes de la Vega, G Fournier, A Valeri, L Cormier, S Larré, O Cussenot
OBJECTIVES: Currently, the French High Authority for Health does not recommend mass screening for prostate cancer (PCa), due to the risk of over-treatment, notably of low risk patients. Our study is intended to reflect the therapeutic attitudes for the management of patients classified as low risk of progression in French clinical centers. METHODS: For all positive prostate biopsies performed during 2012 and 2013 in five French departments of urology, clinicopathological characteristics required to calculate the d'Amico risk group and the Cancer of the Prostate Risk Assessment (CAPRA) score were filled...
February 28, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28258784/results-of-targeted-biopsy-in-men-with-magnetic-resonance-imaging-lesions-classified-equivocal-likely-or-highly-likely-to-be-clinically-significant-prostate-cancer
#12
Wulphert Venderink, Annemarijke van Luijtelaar, Joyce G R Bomers, Marloes van der Leest, Christina Hulsbergen-van de Kaa, Jelle O Barentsz, J P Michiel Sedelaar, Jurgen J Fütterer
BACKGROUND: The Prostate Imaging Reporting and Data System (PI-RADS) is the most commonly used scoring system in prostate magnetic resonance imaging (MRI). One of the available techniques to target suspicious lesions is direct in-bore MRI-guided biopsy (MRGB). OBJECTIVE: To report on the experience and results of MRGB in a large cohort of patients with lesions classified as equivocal (PI-RADS 3), likely (PI-RADS 4), or highly likely (PI-RADS 5) to be clinically significant (cs) prostate cancer (PCa)...
February 28, 2017: European Urology
https://www.readbyqxmd.com/read/28258616/focal-salvage-hifu-in-radiorecurrent-prostate-cancer
#13
A Kanthabalan, M Peters, M Van Vulpen, N McCartan, R G Hindley, A Emara, M C Moore, M Arya, M Emberton, H U Ahmed
OBJECTIVE: To assess short to medium term cancer control rates and side effects of focal salvage High Intensity Focused Ultrasound (HIFU). MATERIALS AND METHODS: A retrospective registry analysis identified 150 men who underwent focal salvage HIFU (Sonablate 500) (November 2006-August 2015). Metastatic disease was excluded using the nodal assessment on the pelvic MRI, a radioisotope bone scan and PET imaging (choline-FDG-PET or Choline PET-CT). In our current clinical practice, metastatic disease must be ruled out by both Choline PET and bone scan...
March 4, 2017: BJU International
https://www.readbyqxmd.com/read/28258355/the-performance-of-pi-radsv2-and-quantitative-apparent-diffusion-coefficient-for-predicting-confirmatory-prostate-biopsy-findings-in-patients-considered-for-active-surveillance-of-prostate-cancer
#14
Stephanie Nougaret, Nicola Robertson, Jennifer Golia Pernicka, Nicolas Molinari, Andreas M Hötker, Behfar Ehdaie, Evis Sala, Hedvig Hricak, Hebert Alberto Vargas
PURPOSE: To assess the performance of the updated Prostate Imaging Reporting and Data System (PI-RADSv2) and the apparent diffusion coefficient (ADC) for predicting confirmatory biopsy results in patients considered for active surveillance of prostate cancer (PCA). METHODS: IRB-approved, retrospective study of 371 consecutive men with clinically low-risk PCA (initial biopsy Gleason score ≤6, prostate-specific antigen <10 ng/ml, clinical stage ≤T2a) who underwent 3T-prostate MRI before confirmatory biopsy...
March 3, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28256901/diagnosis-of-typical-and-atypical-transitional-zone-prostate-cancer-and-its-mimics-at-multiparametric-prostate-mri
#15
Jinxing Yu, Ann S Fulcher, Sarah G Winks, Mary A Turner, Ryan D Clayton, Michael Brooks, Sean Li
Many of the current clinical screening methods for prostate cancer (PCa) such as prostate specific antigen (PSA) testing or trans-rectal ultrasound (TRUS)-guided prostate biopsy lack sensitivity and specificity for diagnosis of PCa of the transition zone (TZ). Recent technical advances in multiparametric-MRI (mp-MRI) have markedly improved detection of PCa of the TZ. However, there are many diagnostic challenges we still encounter in our daily practice that compromise the accuracy of the diagnosis. By performing both MRI-guided and US/MRI fusion-guided biopsies, we have gained extensive experience in the diagnosis of PCa of the TZ...
March 3, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28246496/1-5-tesla-multiparametric-magnetic-resonance-imaging-for-the-detection-of-clinically-significant-prostate-cancer
#16
Cristian Popita, Anca Raluca Popita, Adela Sitar-Taut, Bogdan Petrut, Bogdan Fetica, Ioan Coman
BACKGROUND AND AIM: Multiparametric-magnetic resonance imaging (mp-MRI) is the main imaging modality used for prostate cancer detection. The aim of this study is to evaluate the diagnostic performance of mp-MRI at 1.5-Tesla (1.5-T) for the detection of clinically significant prostate cancer. METHODS: In this ethical board approved prospective study, 39 patients with suspected prostate cancer were included. Patients with a history of positive prostate biopsy and patients treated for prostate cancer were excluded...
2017: Clujul Medical (1957)
https://www.readbyqxmd.com/read/28238758/pathological-findings-in-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-guided-biopsy-relation-to-prostate-cancer-focal-therapy
#17
REVIEW
Jennifer Gordetsky, Soroush Rais-Bahrami, Jonathan I Epstein
The introduction of widespread prostate-specific antigen screening brought about an increase in the detection of clinically low-risk prostate cancer. Many of these patients are overtreated by radical prostatectomy and radiation. Comparatively, focal therapy for prostate cancer offers the advantage of decreased rates of incontinence and impotence. The 12-core extended sextant transrectal ultrasound-guided needle biopsy is unable to safely identify candidates for focal therapy. Multiparametric magnetic resonance imaging (MRI) and MRI/ultrasound fusion-guided biopsy can detect more clinically significant prostate cancers and aid in accurate detection of higher-grade disease...
February 24, 2017: Urology
https://www.readbyqxmd.com/read/28238478/re-diagnostic-accuracy-of-multi-parametric-mri-and-trus-biopsy-in-prostate-cancer-promis-a-paired-validating-confirmatory-study
#18
Jada Kapoor, Alastair D Lamb, Declan G Murphy
No abstract text is available yet for this article.
February 23, 2017: European Urology
https://www.readbyqxmd.com/read/28238033/clinical-and-multiparametric-mri-signatures-of-granulomatous-prostatitis
#19
Soroush Rais-Bahrami, Jeffrey W Nix, Baris Turkbey, Jason A Pietryga, Rupan Sanyal, John V Thomas, Jennifer B Gordetsky
PURPOSE: The purpose of the study is to differentiate granulomatous prostatitis (GP) from high-grade prostate cancer (PCa) based on clinical findings and imaging characteristics on multiparametric MRI (MP-MRI). METHODS: Pathology from patients undergoing MRI/US fusion-guided prostate biopsies between 2014 and 2015 was reviewed. Five patients with biopsy proven GP were identified as well as 15 patients with biopsy-proven Gleason score ≥4 + 3 = 7 PCa. Patients were matched for age, serum PSA level, and prebiopsy-assigned MP-MRI cancer suspicion scores...
February 25, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28236452/multiparametric-magnetic-resonance-imaging-and-prostate-cancer-what-s-new
#20
V Catalá, J C Vilanova, J M Gaya, F Algaba, T Martí
Prostatic multi-parametric magnetic resonance imaging (MP-MRI) has recently had a wide development becoming a key tool in the diagnostic and therapeutic decisions in prostate cancer (Pca). The fast development both in technology and in reading (PIRADS V2) requires a continuous updating of knowledge within this area. The aim of this article is to present an updated revision of technical aspects, reading patterns and prostatic MP-MRI in Pca, with a multidisciplinary approach. Currently guidelines establish the use of the MP-MRI when there is a high PSA and a negative prostatic biopsy; tumor staging; evaluation in candidates to active surveillance; focal treatments plans and tumoral recurrence evaluation...
February 21, 2017: Radiología
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