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Mri and prostate biopsy

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https://www.readbyqxmd.com/read/28927782/development-and-internal-validation-of-prediction-models-for-biochemical-failure-and-composite-failure-after-focal-salvage-high-intensity-focused-ultrasound-for-local-radiorecurrent-prostate-cancer-presentation-of-risk-scores-for-individual-patient-prognoses
#1
Max Peters, Abi Kanthabalan, Taimur T Shah, Neil McCartan, Caroline M Moore, Manit Arya, Jochem R van der Voort van Zyp, Marinus A Moerland, Richard G Hindley, Mark Emberton, Hashim U Ahmed
PURPOSE: Patient selection for focal salvage remains difficult. Therefore, we developed and internally validated prediction models for biochemical failure (BF) and a composite endpoint (CE) following focal salvage high intensity focused ultrasound (HIFU) for radiorecurrent prostate cancer. MATERIALS AND METHODS: A prospective HIFU registry identified 150 cases (November 2006-August 2015). Recurrence was assessed with multiparametric magnetic resonance imaging (MRI) combined with template prostate mapping biopsies, targeted biopsies, or systematic transrectal ultrasound-guided biopsies...
September 15, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28921850/prospective-comparison-of-transperineal-mri-ultrasound-fusion-biopsy-and-transrectal-systematic-biopsy-in-biopsy-na%C3%A3-ve-patients
#2
Angelika Borkowetz, Boris Hadaschik, Ivan Platzek, Marieta Toma, Georgi Torsev, Theresa Renner, Roman Herout, Martin Baunacke, Michael Laniado, Gustavo Baretton, Jan Philipp Radtke, Claudia Kesch, Markus Hohenfellner, Michael Froehner, Heinz-Peter Schlemmer, Manfred Wirth, Stefan Zastrow
OBJECTIVES: To evaluate the value of multiparametric magnetic resonance imaging (mpMRI) for the detection of significant prostate cancer (PCa) and to compare transperineal MRI/ultrasound-fusion biopsy (fusPbx) to conventional transrectal systematic biopsy (sysPbx) in biopsy-naïve patients. PATIENTS AND METHODS: This multicentre, prospective trial investigated biopsy-naïve patients with suspicion of PCa undergoing transperineal fusPbx in combination with transrectal sysPbx (comPbx)...
September 16, 2017: BJU International
https://www.readbyqxmd.com/read/28912459/iron-deposition-is-associated-with-differential-macrophage-infiltration-and-therapeutic-response-to-iron-chelation-in-prostate-cancer
#3
Avigdor Leftin, Huiyong Zhao, Mesru Turkekul, Elisa de Stanchina, Katia Manova, Jason A Koutcher
Immune cells such as macrophages are drivers and biomarkers of most cancers. Scoring macrophage infiltration in tumor tissue provides a prognostic assessment that is correlated with disease outcome and therapeutic response, but generally requires invasive biopsy. Routine detection of hemosiderin iron aggregates in macrophages in other settings histologically and in vivo by MRI suggests that similar assessments in cancer can bridge a gap in our ability to assess tumor macrophage infiltration. Quantitative histological and in vivo MRI assessments of non-heme cellular iron revealed that preclinical prostate tumor models could be differentiated according to hemosiderin iron accumulation-both in tumors and systemically...
September 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28906339/multiparametric-magnetic-resonance-imaging-of-prostate-cancer-bone-disease-correlation-with-bone-biopsy-histological-and-molecular-features
#4
Raquel Perez-Lopez, Daniel Nava Rodrigues, Ines Figueiredo, Joaquin Mateo, David J Collins, Dow-Mu Koh, Johann S de Bono, Nina Tunariu
OBJECTIVES: The aim of this study was to correlate magnetic resonance imaging (MRI) of castration-resistant prostate cancer (CRPC) bone metastases with histological and molecular features of bone metastases. MATERIALS AND METHODS: Forty-three bone marrow biopsies from 33 metastatic CRPC (mCRPC) patients with multiparametric MRI and documented bone metastases were evaluated. A second cohort included 10 CRPC patients with no bone metastases. Associations of apparent diffusion coefficient (ADC), normalized b900 diffusion-weighted imaging (nDWI) signal, and signal-weighted fat fraction (swFF) with bone marrow biopsy histological parameters were evaluated using Mann-Whitney U test and Spearman correlations...
September 12, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28902738/false-positive-pancreatic-uptake-detected-on-68ga-psma-pet-ct-a-priority-changing-incidental-finding-while-assessing-the-need-for-a-prostate-biopsy
#5
Mehmet Onur Demirkol, Murat Can Kiremit, Omer Acar, Alan Alper Sag, Yersu Kapran
A 72-year-old man underwent Ga-PSMA PET/CT because of an elevated prostate-specific antigen level despite prior prostatectomy. Besides low-intensity prostatic PSMA reactivities, a faintly PSMA-positive lesion in the pancreatic corpus drew attention, which seemed suggestive of a primary pancreatic cancer on the subsequent MRI and therefore had to be excised. The final diagnosis was pT3 low-grade neuroendocrine tumor. PSMA-positive incidentalomas, detected on Ga-PSMA PET/CT, can reveal more clinically significant extraprostatic disorders...
September 11, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28894899/clinical-impact-of-psma-based-18-f-dcfbc-pet-ct-imaging-in-patients-with-biochemically-recurrent-prostate-cancer-after-primary-local-therapy
#6
Esther Mena, Maria L Lindenberg, Joanna H Shih, Stephen Adler, Stephanie Harmon, Ethan Bergvall, Deborah Citrin, William Dahut, Anita T Ton, Yolanda McKinney, Juanita Weaver, Philip Eclarinal, Alicia Forest, George Afari, Sibaprasad Bhattacharyya, Ronnie C Mease, Maria J Merino, Peter Pinto, Bradford J Wood, Paula Jacobs, Martin G Pomper, Peter L Choyke, Baris Turkbey
PURPOSE: The purpose of our study was to assess (18)F-DCFBC PET/CT, a PSMA targeted PET agent, for lesion detection and clinical management of biochemical relapse in prostate cancer patients after primary treatment. METHODS: This is a prospective IRB-approved study of 68 patients with documented biochemical recurrence after primary local therapy consisting of radical prostatectomy (n = 50), post radiation therapy (n = 9) or both (n = 9), with negative conventional imaging...
September 11, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28893523/-therapeutic-innovations-in-urology-for-localized-prostate-cancer
#7
L Cormier, G Créhange
The management of localized prostate cancer has been marked over these last years by the importance of Active Surveillance for low risk forms. Indeed, the long follow-up and the quality of the results are now sufficient to offer this option even in relatively young people. However, the question is still under investigation concerning intermediate risk of prostate cancer. Patients' selection and follow-up management are of very high importance. Another major evolution is the robotic assistance for radical prostatectomy...
September 8, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28872226/prebiopsy-multiparametric-mri-based-risk-score-for-predicting-prostate-cancer-in-biopsy-naive-men-with-prostate-specific-antigen-between-4-10%C3%A2-ng-ml
#8
Durgesh Kumar Dwivedi, Rajeev Kumar, Alok Kumar Dwivedi, Girdhar S Bora, Sanjay Thulkar, Sanjay Sharma, Siddhartha Datta Gupta, Naranamangalam R Jagannathan
BACKGROUND: Risk calculators have traditionally utilized serum prostate-specific antigen (PSA) values in addition to clinical variables to predict the likelihood of prostate cancer (PCa). PURPOSE: To develop a prebiopsy multiparametric MRI (mpMRI)-based risk score (RS) and a statistical equation for predicting the risk of PCa in biopsy-naive men with serum PSA between 4-10 ng/mL that may help reduce unnecessary biopsies. STUDY TYPE: Prospective cross-sectional study...
September 4, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28871396/retrospective-comparison-of-direct-in-bore-magnetic-resonance-imaging-mri-guided-biopsy-and-fusion-guided-biopsy-in-patients-with-mri-lesions-which-are-likely-or-highly-likely-to-be-clinically-significant-prostate-cancer
#9
Wulphert Venderink, Marloes van der Leest, Annemarijke van Luijtelaar, Wendy J M van de Ven, Jurgen J Fütterer, J P Michiel Sedelaar, Henkjan J Huisman
PURPOSE: To compare clinically significant prostate cancer (csPCa) detection rates between magnetic resonance imaging (MRI)-transrectal ultrasound (TRUS) fusion-guided prostate biopsy (FGB) and direct in-bore MRI-guided biopsy (MRGB). METHODS: We performed a comparison of csPCa detection rates between FGB and MRGB. Included patients had (1) at least one prior negative TRUS biopsy; (2) a Prostate Imaging Reporting and Data System (PI-RADS) 4 or 5 lesion and (3) a lesion size of ≥8 mm measured in at least one direction...
September 4, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/28870929/diffusion-weighted-mri-provides-a-useful-biomarker-for-evaluation-of-radiotherapy-efficacy-in-patients-with-prostate-cancer
#10
Xingchen Wu, Petri Reinikainen, Mika Kapanen, Tuula Vierikko, Pertti Ryymin, Pirkko-Liisa Kellokumpu-Lehtinen
BACKGROUND: Diffusion-weighted imaging (DWI) with measurement of apparent diffusion coefficient (ADC) allows for assessment of tumor aggressiveness. The objective of this study was to evaluate the changes of ADC value in prostate cancer after volumetric-modulated arc radiotherapy (VMAT) and to identify magnetic resonance imaging (MRI) biomarkers for monitoring tissue changes after radiotherapy. PATIENTS AND METHODS: Thirty-seven patients with biopsy-proven prostate cancer treated with VMAT underwent serial MRI examinations including DWI before radiotherapy, and at 3 and 12 months after radiotherapy...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28867930/mr-safe-robot-fda-clearance-safety-and-feasibility-prostate-biopsy-clinical-trial
#11
Dan Stoianovici, Chunwoo Kim, Doru Petrisor, Changhan Jun, Sunghwan Lim, Mark W Ball, Ashley Ross, Katarzyna J Macura, Mohamad Allaf
Compatibility of mechatronic devices with the MR environment has been a very challenging engineering task. After over a decade of developments, we report the successful translation to clinical trials of our MR Safe robot technology. MrBot is a 6-degree-of-freedom, pneumatically actuated robot for transperineal prostate percutaneous access, built exclusively of electrically nonconductive and nonmagnetic materials. Its extensive pre-clinical tests have been previously reported. Here, we present the latest technology developments, an overview of the regulatory protocols, and technically related results of the clinical trial...
February 2017: IEEE/ASME Transactions on Mechatronics
https://www.readbyqxmd.com/read/28867582/-pathological-findings-of-visible-and-non-visible-tumors-on-multiparametric-magnetic-resonance-imaging-mri-prior-to-radical-prostatectomy
#12
A Rivière, F Cornud, F Beuvon, M Sibony, P Legmann, N Barry Delongchamps
INTRODUCTION: As urologists are questioned about the overtreatment of localized prostate cancer, multiparametric MRI can diagnose significant prostate cancer thanks to targeted biopsies. However, some tumors cannot be detected by MRI. What are the pathological characteristics of those tumors? MATERIALS AND METHODS: We have selected 144 consecutive patients treated with radical prostatectomy for clinically localized prostate cancer diagnosed on systematic and targeted biopsies (Koelis(®)) according to multiparametric MRI findings...
August 31, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28866023/where-do-trus-and-mri-guided-biopsies-miss-significant-prostate-cancer
#13
Lars Boesen, Nis Nørgaard, Vibeke Løgager, Ingegerd Balslev, Henrik S Thomsen
OBJECTIVE: To identify the location of missed sPCa lesions by transrectal ultrasound-guided (TRUSbx) and multiparametric MRI-guided biopsies (mpMRIbx) in men undergoing repeat biopsies. METHODS: 289 men with prior negative TRUSbx underwent mpMRI. The location of any suspicious lesion was registered and scored using PIRADS v1 classification according to the likelihood of being sPCa. All patients underwent repeat (re-)TRUSbx and targeted mpMRIbx (image fusion) of any suspicious lesion...
August 30, 2017: Urology
https://www.readbyqxmd.com/read/28861291/score-3-prostate-lesions-a-gray-zone-for-pi-rads-v2
#14
REVIEW
Michele Scialpi, Eugenio Martorana, Maria Cristina Aisa, Valeria Rondoni, Alfredo D'Andrea, Giampaolo Bianchi
Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) does not offer a precise guidance on the clinical management (biopsy or not biopsy) for PI-RADS v2 score 3 lesions. Lesion volume calculated on biparametric MRI (bpMRI) [T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI)] by introducing a cut-off of 0.5 mL, allows to distinguish the lesions assigned by the multiparametric MRI (mpMRI) to the category PI-RADS v2 score 3 in two subgroups: a) Indolent or low risk lesions with volume <0...
September 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28858541/risk-stratification-among-men-with-prostate-imaging-reporting-and-data-system-version-2-category-3-transition-zone-lesions-is-biopsy-always-necessary
#15
Ely R Felker, Steven S Raman, Daniel J Margolis, David S K Lu, Nicholas Shaheen, Shyam Natarajan, Devi Sharma, Jiaoti Huang, Fred Dorey, Leonard S Marks
OBJECTIVE: The objective of our study was to determine the clinical and MRI characteristics of clinically significant prostate cancer (PCA) (Gleason score ≥ 3 + 4) in men with Prostate Imaging Reporting and Data System Version 2 (PI-RADSv2) category 3 transition zone (TZ) lesions. MATERIALS AND METHODS: From 2014 to 2016, 865 men underwent prostate MRI and MRI/ultrasound (US) fusion biopsy (FB). A subset of 90 FB-naïve men with 96 PI-RADSv2 category 3 TZ lesions was identified...
August 31, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28856386/-focal-therapy-of-prostate-cancer
#16
R Ganzer, T Franiel, J Köllermann, T Kuru, D Baumunk, A Blana, B Hadaschik, J von Hardenberg, T Henkel, K-U Köhrmann, U-B Liehr, S Machtens, A Roosen, G Salomon, H-P Schlemmer, L Sentker, J Wendler, U Witzsch, M Schostak
The target of focal therapy (FT) in prostate cancer (PC) is partial treatment of the prostate aiming at preserving surrounding anatomical structures. The intention is to minimize typical side effects of radical treatment options combined with local tumor control. Numerous established and new technologies are used. Results of published studies showed a good safety profile, few side effects and good preservation of functional results. Oncologic long-term data are lacking so far. Photodynamic therapy (PDT) is the only technology that has been studied in a published prospective randomized trial...
August 30, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28853678/hpv-related-squamous-cell-carcinoma-in-a-neovagina-after-male-to-female-gender-confirmation-surgery
#17
Jesús Bollo, Andrea Balla, Carlos Rodriguez Luppi, Carmen Martinez, Silvia Quaresima, Eduard M Targarona
Vaginoplasty by penile and scrotal skin inversion is a well-established technique for male-to-female gender confirmation surgery. In this setting, chronic inflammation and lacerations associated with history of human papillomavirus (HPV) infection may induce a high risk of malignant degeneration in the long term. A 78-year-old transgender woman was admitted with genital discomfort and neovaginal discharge. The patient's history revealed male-to-female gender confirmation surgery with construction of a neovagina by penile and scrotal skin inversion at 33 years of age...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28853167/a-urinary-biomarker-based-risk-score-correlates-with-multiparametric-mri-for-prostate-cancer-detection
#18
Rianne J Hendriks, Marloes M G van der Leest, Siebren Dijkstra, Jelle O Barentsz, Wim Van Criekinge, Christina A Hulsbergen-van de Kaa, Jack A Schalken, Peter F A Mulders, Inge M van Oort
BACKGROUND: Prostate cancer (PCa) diagnostics would greatly benefit from more accurate, non-invasive techniques for the detection of clinically significant disease, leading to a reduction of over-diagnosis and over-treatment. The aim of this study was to determine the association between a novel urinary biomarker-based risk score (SelectMDx), multiparametric MRI (mpMRI) outcomes, and biopsy results for PCa detection. METHODS: This retrospective observational study used data from the validation study of the SelectMDx score, in which urine was collected after digital rectal examination from men undergoing prostate biopsies...
August 29, 2017: Prostate
https://www.readbyqxmd.com/read/28844600/prostate-specific-antigen-parameters-and-prostate-health-index-enhance-prostate-cancer-prediction-with-the-in-bore-3-t-mri-guided-transrectal-targeted-prostate-biopsy-after-negative-12-core-biopsy
#19
Alexander Friedl, Kathrin Stangl, Wilhelm Bauer, Danijel Kivaranovic, Jenifer Schneeweiss, Martin Susani, Stephan Hruby, Lukas Lusuardi, Fritz Lomoschitz, Edith Eisenhuber-Stadler, Wolfgang Schima, Clemens Brössner
Objectives To assess prostate cancer (PCa) detection and prediction by combining the in-bore MRI-guided transrectal targeted prostate biopsy (MRGB) with prostate-specific antigen (PSA) parameters and the prostate health index (PHI) in case of negative 12-core standard biopsy (SB). Methods A total of 112 males (2014-2016) underwent 3.0T multi-parametric MRI (mpMRI) and subsequent MRGB of Prostate Imaging Reporting and Data System (PI-RADS) lesions 3-5. Ancillary PSA parameters (PSA ratio [%fPSA], PSA density [PSAD]) and the PHI and PHI density (PHID) were recorded...
August 24, 2017: Urology
https://www.readbyqxmd.com/read/28842208/reclassification-rates-of-patients-eligible-for-active-surveillance-after-the-addition-of-mri-us-fusion-biopsy-an-analysis-of-seven-widely-used-eligibility-criteria
#20
Bruno Nahar, Andrew Katims, Marcelo Panizzutti Barboza, Nachiketh Soodana Prakash, Vivek Venkatramani, Bruce Kava, Ramgopal Satyanarayana, Mark L Gonzalgo, Chad R Ritch, Dipen J Parekh, Sanoj Punnen
OBJECTIVES: To evaluate the impact of adding MRI-US fusion biopsy cores to standard 12-core biopsy in selecting men for Active Surveillance(AS). MATERIALS AND METHODS: Among men undergoing a fusion biopsy for evaluation of prostate cancer, we selected men who were eligible for at least one of seven different AS criteria based on the standard biopsy alone. We assessed each patient's eligibility for each AS criteria with and without the inclusion of fusion biopsy cores...
August 22, 2017: Urology
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