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https://www.readbyqxmd.com/read/29238193/in-vivo-evaluation-of-a-novel-nanocomposite-porous-3d-scaffold-in-a-rabbit-model-histological-analysis
#1
Saffanah Khuder Mahmood, Intan-Shameha Abdul Razak, Mustafa Saddam Ghaji, Loqman Mohamed Yusof, Zaid Khudhur Mahmood, Mohd Adha Bin P Rameli, Zuki Abu Bakar Zakaria
The healing of load-bearing segmental defects in long bones is a challenge due to the complex nature of the weight that affects the bone part and due to bending, shearing, axial, and torsional forces. An innovative porous 3D scaffolds implant of CaCO3 aragonite nanocomposite derived from cockle shell was advanced for substitute bone solely for load-bearing cases. The biomechanical characteristics of such materials were designed to withstand cortical bone strength. In promoting bone growth to the implant material, an ideal surface permeability was formed by means of freeze drying and by adding copolymers to the materials...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29236922/effects-of-n-acetylcysteine-on-amphetamine-induced-sensitization-in-mice
#2
Ana P Herrmann, Roberta Andrejew, Radharani Benvenutti, Clarissa S Gama, Elaine Elisabetsky
OBJECTIVE: N-acetylcysteine (NAC) is beneficial in psychiatric conditions, including schizophrenia. Patients with schizophrenia exhibit mesolimbic dopamine hyperfunction consequent to an endogenous sensitization process. This sensitization can be modeled in rodents by repeated exposure to psychostimulants, provoking an enduring amplified response at subsequent exposure. The aim of this study was to investigate the effects of NAC on amphetamine sensitization in mice. METHODS: D-amphetamine was administered to C57BL/6 mice three times a week for 3 weeks; the dose was increased weekly from 1 to 3 mg/kg...
December 11, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/29234916/do-acute-effects-of-exercise-on-vascular-function-predict-adaptation-to-training
#3
Ellen A Dawson, N Timothy Cable, Daniel J Green, Dick H J Thijssen
PURPOSE: No previous study has explored the importance of exercise-induced changes in vascular function to prolonged adaptations. Therefore, the purpose was to explore the within-subject relationship between the acute post-exercise change in brachial artery endothelial function (flow-mediated dilation, FMD) and the change in resting FMD after a 2-week exercise training in healthy volunteers. METHODS: Twenty one healthy, young men (24 ± 5 years) underwent assessment of brachial artery FMD using high-resolution ultrasound before and after 30-min of moderate-intensity cycle exercise (80% maximal heart rate)...
December 12, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29232099/the-effect-of-graphene-ec-on-ag-nw-based-transparent-film-heaters-optimizing-the-stability-and-heat-dispersion-of-film
#4
Minghui Cao, Minqiang Wang, Le Li, Hengwei Qiu, Zhi Yang
In order to optimize the performance of silver nanowire (Ag NW) film heaters and explore the effect of graphene on the film, we introduced the poly (3, 4-ethylenedioxythiophene): poly (4-styrenesulfonate) (PEDOT: PSS) and graphene modified with ethyl cellulose (graphene-EC) into the film in this paper. The high quality and well-dispersed graphene-EC was synthesized with graphene obtained by electrochemical exfoliation as precursor. The transparent film heaters were fabricated via spin-coating. With the assistance of graphene-EC, the stability of the film heaters was greatly improved and the conductivity was optimized by adjusting Ag NW concentration...
December 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29226053/compression-stockings-and-pressure-ulcers-case-series-of-a-neglected-issue
#5
Farooq A Rathore, Faria Ahmad, Omer J Khan
Pressure ulcers develop in patients who endure long periods of immobilization, often caused by conditions such as musculoskeletal and neurological diseases. Pressure ulcers adversely affect the patient and increase caregiver burden and healthcare costs. Typical sites for these ulcers include the sacrum, trochanters, and heels; they also occur on the nape of the neck, penis, nostrils, helix of the ear, and upper back. Compression stockings are commonly used to prevent and stop the progression of venous disorders, including deep vein thrombosis, but their role in the development of pressure ulcers is not well known...
October 10, 2017: Curēus
https://www.readbyqxmd.com/read/29225311/inhibition-of-oxidative-stress-by-antioxidant-supplementation-does-not-limit-muscle-mitochondrial-biogenesis-or-endurance-capacity-in-rats
#6
Jae Cheol Kim, Gi Duck Park, Sang Hyun Kim
The objective of the present study was to analyze the activation and expression patterns of upstream and downstream factors of PGC-1α to determine whether antioxidant (AO) supplementation inhibits mitochondrial biogenesis in skeletal muscles as an adaptation to endurance training, as well as to analyze changes in endurance capacity based on such findings. For this objective, 24 male Sprague-Dawley (SD) rats were allocated into 4 groups (vehicle-sedentary, V-Sed; vehicle-exercise, V-EX; antioxidant-sedentary, AO-Sed; antioxidant-exercise, AO-EX) of 6 rats each...
2017: Journal of Nutritional Science and Vitaminology
https://www.readbyqxmd.com/read/29215475/an-effective-bundled-approach-reduces-surgical-site-infections-in-a-high-outlier-colorectal-unit
#7
Emre Gorgun, Ahmet Rencuzogullari, Volkan Ozben, Luca Stocchi, Thomas Fraser, Cigdem Benlice, Tracy Hull
BACKGROUND: Surgical site infections are the most common hospital-acquired infection after colorectal surgery, increasing morbidity, mortality, and hospital costs. OBJECTIVE: The purpose of this study was to investigate the impact of preventive measures on colorectal surgical site infection rates in a high-volume institution that performs inherent high-risk procedures. DESIGN: This was a prospective cohort study. SETTINGS: The study was conducted at a high-volume, specialized colorectal surgery department...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29214370/lumbar-intervertebral-disc-allograft-transplantation-the-revascularisation-pattern
#8
Yong-Can Huang, Jun Xiao, Victor Y Leung, William W Lu, Yong Hu, Keith D K Luk
PURPOSE: Fresh frozen intervertebral disc allograft transplantation has been reported to be a viable treatment option for advanced degenerative disc diseases, but rapid degeneration of the postoperative allograft was found. Loss of nutrient supply is believed to be the most likely inducer because the disc allografts have to endure in an ischaemic environment until the nutrient pathway is re-established. The aim of this study was to focus on the revascularisation of the disc allograft after transplantation in goats...
December 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29203287/effects-of-endurance-training-on-serum-lipids
#9
REVIEW
Kati Fikenzer, Sven Fikenzer, Ulrich Laufs, Christian Werner
BACKGROUND AND AIMS: Physical activity is recommended as part of the lifestyle modification for the treatment of hyperlipidemia, however, the literature reports heterogeneous quantitative effects of exercise on serum lipids. We therefore reviewed the effects of aerobic exercise on serum lipids with special focus on the training effectiveness. METHODS: Data regarding effects of endurance training (ET) on total Cholesterol (TC), LDL-Cholesterol (LDL-C), HDL-Cholesterol (HDL-C) and triglycerides (TG) were evaluated in a selective literature search...
December 1, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/29191052/a-randomized-controlled-trial-of-resistance-and-endurance-exercise-in-amyotrophic-lateral-sclerosis
#10
Lora L Clawson, Merit Cudkowicz, Lisa Krivickas, Benjamin R Brooks, Mohammed Sanjak, Peggy Allred, Nazem Atassi, Amy Swartz, Gabrielle Steinhorn, Alpa Uchil, Kristen M Riley, Hong Yu, David A Schoenfeld, Nicholas J Maragakis
OBJECTIVE: Evaluate the safety and tolerability of resistance and endurance exercise in ALS participants as measured by their ability to complete this six-month study. METHODS: Participants were randomized to Resistance, Endurance, or Stretching/Range of Motion (SROM the exercise regimen prescribed for most ALS patients) exercises. All exercises were performed at home with an individualized regimen designed by a physical therapist trained in ALS management. Primary outcome measures were tolerability of the exercises at 24 weeks defined by 50% of participants completing at least 50% of the prescribed exercise regimen...
November 30, 2017: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
https://www.readbyqxmd.com/read/29189337/postexercise-hypotension-as-a-predictor-for-long-term-training-induced-blood-pressure-reduction-a-large-scale-randomized-controlled-trial
#11
Melissa Wegmann, Anne Hecksteden, Wigand Poppendieck, Anke Steffen, Jochen Kraushaar, Arne Morsch, Tim Meyer
OBJECTIVE: To investigate the correlation between acute exercise effects and chronic training effects on blood pressure (BP). DESIGN: Randomized, controlled training study focusing on the optimization of preventive effects of physical training. SETTING: The study was performed in a university department. PARTICIPANTS: One hundred twenty-seven healthy, untrained subjects. INTERVENTION: Subjects were divided into 4 groups: interval endurance training (IET) (n = 26, 4 × 4 min at 95% maximal heart rate), continuous endurance training (CET) (n = 23, 45 minutes at 60% heart rate reserve), strength endurance training (SET) (n = 40, 8 machine-based exercises, each 2 x 15 repetitions at the 20 repetition maximum), and control (CON) (n = 38)...
November 16, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29181673/relative-transcription-of-autophagy-related-genes-in-amblyomma-sculptum-and-rhipicephalus-microplus-ticks
#12
Nicole O Moura-Martiniano, Erik Machado-Ferreira, Gilberto S Gazêta, Carlos Augusto Gomes Soares
Ticks endure stressful off-host periods and perform as vectors of a diversity of infectious agents, thus engaging pathways that expectedly demand for autophagy. Little is known of ticks' autophagy, a conserved eukaryotic machinery assisting in homeostasis processes that also participates in tissue-dependent metabolic functions. Here, the autophagy-related ATG4 (autophagin-1), ATG6 (beclin-1) and ATG8 (LC3) mRNAs from the human diseases vector Amblyomma sculptum and the cattle-tick Rhipicephalus microplus were identified...
November 27, 2017: Experimental & Applied Acarology
https://www.readbyqxmd.com/read/29180952/maintenance-of-positional-identity-of-neural-progenitors-in-the-embryonic-and-postnatal-telencephalon
#13
Ryan N Delgado, Daniel A Lim
Throughout embryonic development and into postnatal life, regionally distinct populations of neural progenitor cells (NPCs) collectively generate the many different types of neurons that underlie the complex structure and function of the adult mammalian brain. At very early stages of telencephalic development, NPCs become organized into regional domains that each produce different subsets of neurons. This positional identity of NPCs relates to the regional expression of specific, fate-determining homeodomain transcription factors...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29180856/effects-of-comprehensive-geriatric-assessment-on-physical-fitness-in-an-acute-medical-setting-for-frail-elderly-patients
#14
Kristina Åhlund, Maria Bäck, Birgitta Öberg, Niklas Ekerstad
Introduction: Frail elderly people often use emergency care. During hospitalization, physical decline is common, implying an increased risk of adverse health outcomes. Comprehensive Geriatric Assessment (CGA) has been shown to be beneficial for these patients in hospital care. However, there is very limited evidence about the effects on physical fitness. The aim was to compare effects on physical fitness in the acute care of frail elderly patients at a CGA unit versus conventional care, 3 months after discharge...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29178553/advancing-alcohol-research-and-treatment-contentions-and-debates-about-treatment-intensity-goals-and-outcomes-in-the-1970s-and-1980s
#15
Steve Allsop
AIMS: This narrative exploration of alcohol treatment research focuses on key contentions and advances in alcohol treatment during the critical 1970s and 1980s. METHODS: Papers and books which signal some of the major debates and advances in alcohol treatment research were selected from the 1970s and 1980s. The selection process was based on significant debate during this period, and included those that influenced the field in general and this author in particular...
November 27, 2017: Addiction
https://www.readbyqxmd.com/read/29174737/the-role-of-media-in-preventing-student-suicides-a-hong-kong-experience
#16
Qijin Cheng, Feng Chen, Esther S T Lee, Paul S F Yip
INTRODUCTION: In view of the surge of student suicides in March 2016, a large-scale media involvement was engaged to minimize copycat effects and to extensively spread more preventive information. METHODS: Trend differences between student suicides in overall as well as youth suicides between 2003 and 2016 were examined. Impacts of media involvement were examined as to the changes of their intensities in reporting student suicides in different manners. Local polynomial smoothing method was used to estimate the intensities throughout the study period...
November 7, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29173470/effect-of-long-term-aerobic-anaerobic-and-aerobic-anaerobic-physical-training-in-seric-toxic-minerals-concentrations
#17
Marcos Maynar-Mariño, Francisco Llerena, Ignacio Bartolomé, Carmen Crespo, Diego Muñoz, María-Concepción Robles, María-Jesús Caballero
BACKGROUND: Many substances poured out from industries can be toxic to humans and can impair physical performance. Besides, physical training may modify the body concentrations of these substances as a result of physiological adaptations. OBJECTIVES: The aim of the study was to determine if different modalities of exercise might affect serum concentrations of toxic trace elements in sportsmen. METHODS: 80 Spanish national sportsmen were recruited before the start of their training period...
January 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29169664/long-term-efficacy-of-psychotherapy-for-posttraumatic-stress-disorder-a-meta-analysis-of-randomized-controlled-trials
#18
REVIEW
Alexander C Kline, Andrew A Cooper, Nina K Rytwinksi, Norah C Feeny
Psychotherapies are well established as efficacious acute interventions for posttraumatic stress disorder (PTSD). However, the long-term efficacy of such interventions and the maintenance of gains following termination is less understood. This meta-analysis evaluated enduring effects of psychotherapy for PTSD in randomized controlled trials (RCTs) with long-term follow-ups (LTFUs) of at least six months duration. Analyses included 32 PTSD trials involving 72 treatment conditions (N=2935). Effect sizes were significantly larger for active psychotherapy conditions relative to control conditions for the period from pretreatment to LTFU, but not posttreatment to LTFU...
November 20, 2017: Clinical Psychology Review
https://www.readbyqxmd.com/read/29166320/exercise-alters-gut-microbiota-composition-and-function-in-lean-and-obese-humans
#19
Jacob M Allen, Lucy J Mailing, Grace M Niemiro, Rachel Moore, Mark D Cook, Bryan A White, Hannah D Holscher, Jeffrey A Woods
PURPOSE: Exercise is associated with altered gut microbial composition, but studies have not investigated whether the gut microbiota and associated metabolites are modulated by exercise training in humans. We explored the impact of six weeks of endurance exercise on the composition, functional capacity, and metabolic output of the gut microbiota in lean and obese adults with multiple-day dietary controls prior to outcome variable collection. METHODS: Thirty-two lean (n=18 [9 female]) and obese (n=14 [11 female]), previously sedentary subjects participated in six weeks of supervised, endurance-based exercise training (3 days/wk) that progressed from 30 to 60 minutes/day and from moderate (60% of heart rate reserve [HRR]) to vigorous intensity (75% HRR)...
November 20, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29165681/diaphragmatic-function-in-infants-and-children-with-congenital-diaphragmatic-hernia-a-cross-sectional-study
#20
Sonia Khirani, Alessandro Amaddeo, Naziha Khen-Dunlop, Jorge Olmo Arroyo, Alexandre Lapillonne, Odile Becquet, Elsa Kermorvant-Duchemin, Sylvie Beaudoin, Véronique Rousseau, Christophe Delacourt, Brigitte Fauroux
OBJECTIVES: Few studies have evaluated long-term diaphragmatic function in congenital diaphragmatic hernia (CDH). The aim of our cross-sectional study was to assess diaphragmatic function in infants and young children with CDH after surgical repair. METHODS: All the patients with CDH repair followed in our centre between February 2014 and January 2016 were enrolled. Patients with a postnatal diagnosis after 1 month of life were excluded. Breathing pattern and diaphragmatic function were assessed using esophageal and gastric (Pgas) pressure recording after surgery, or at 1 or 5 years of age...
November 20, 2017: European Journal of Cardio-thoracic Surgery
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