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https://www.readbyqxmd.com/read/29049845/impact-of-the-initial-fitness-level-on-the-effects-of-a-structured-exercise-therapy-during-pediatric-stem-cell-transplantation
#1
Susanne Wallek, Anna Senn-Malashonak, Lutz Vogt, Katharina Schmidt, Peter Bader, Winfried Banzer
BACKGROUND: Before and after hematopoietic stem cell transplantation (HSCT), most patients suffer from psychophysical limitations due to the treatment. Exercise interventions demonstrate beneficial effects on, for example, strength, endurance, or health-related quality of life during and after HSCT, but with a great variation among patients concerning the response to exercise. This study examines the influence of the initial fitness on the effects of an exercise therapy in pediatric HSCT...
October 19, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29049322/pgc-1%C3%AE-and-exercise-intensity-dependent-adaptations-in-mouse-skeletal-muscle
#2
Nina Brandt, Maja Munk Dethlefsen, Jens Bangsbo, Henriette Pilegaard
The aim of the present study was to examine the role of PGC-1α in intensity dependent exercise and exercise training-induced metabolic adaptations in mouse skeletal muscle. Whole body PGC-1α knockout (KO) and littermate wildtype (WT) mice performed a single treadmill running bout at either low intensity (LI) for 40 min or moderate intensity (MI) for 20 min. Blood and quadriceps muscles were removed either immediately after exercise or at 3h or 6h into recovery from exercise and from resting controls. In addition PGC-1α KO and littermate WT mice were exercise trained at either low intensity (LIT) for 40 min or at moderate intensity (MIT) for 20 min 2 times pr...
2017: PloS One
https://www.readbyqxmd.com/read/29036325/it-s-all-in-the-timing-calibrating-temporal-penalties-for-biomedical-data-sharing
#3
Weiyi Xia, Zhiyu Wan, Zhijun Yin, James Gaupp, Yongtai Liu, Ellen Wright Clayton, Murat Kantarcioglu, Yevgeniy Vorobeychik, Bradley A Malin
Objective: Biomedical science is driven by datasets that are being accumulated at an unprecedented rate, with ever-growing volume and richness. There are various initiatives to make these datasets more widely available to recipients who sign Data Use Certificate agreements, whereby penalties are levied for violations. A particularly popular penalty is the temporary revocation, often for several months, of the recipient's data usage rights. This policy is based on the assumption that the value of biomedical research data depreciates significantly over time; however, no studies have been performed to substantiate this belief...
September 26, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/29035591/effect-of-intensified-endurance-training-on-pacing-and-performance-in-4000m-cycling-time-trials
#4
Alice M Wallett, Amy L Woods, Nathan G Versey, Laura A Garvican-Lewis, Marijke Welvaert, Kevin G Thompson
Studies examining pacing strategies during 4000m cycling time-trials (TTs) typically ensure participants are not pre-fatigued, however competitive cyclists often undertake TTs when already pre-fatigued. This study aimed to determine how TT pacing strategies and sprint characteristics of cyclists change during an intensified training period (mesocycle). Thirteen cyclists, regularly competing in A and B grade cycling races and consistently training (>10 h·wk-1 for 4±1 years), completed a six-week training mesocycle...
October 16, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29019274/effects-of-whole-body-vibration-on-balance-and-mobility-in-institutionalized-older-adults-a-randomized-controlled-trial
#5
Freddy Mh Lam, Philip Fl Chan, L R Liao, Jean Woo, Elsie Hui, Charles Wk Lai, Timothy Cy Kwok, Marco Yc Pang
OBJECTIVE: To investigate whether a comprehensive exercise program was effective in improving physical function among institutionalized older adults and whether adding whole-body vibration to the program conferred additional therapeutic benefits. DESIGN: A single-blinded randomized controlled trial was conducted. SETTING: This study was carried out in residential care units. PARTICIPANTS: In total, 73 older adults (40 women, mean age: 82...
October 1, 2017: Clinical Rehabilitation
https://www.readbyqxmd.com/read/29018362/effects-of-unloaded-vs-loaded-plyometrics-on-speed-and-power-performance-of-elite-young-soccer-players
#6
Ronaldo Kobal, Lucas A Pereira, Vinicius Zanetti, Rodrigo Ramirez-Campillo, Irineu Loturco
The purpose of this study was to investigate the effects of loaded and unloaded plyometric training strategies on speed and power performance of elite young soccer players. Twenty-three under-17 male soccer players (age: 15.9 ± 1.2 years, height: 178.3 ± 8.1 cm, body-mass (BM): 68.1 ± 9.3 kg) from the same club took part in this study. The athletes were pair-matched in two training groups: loaded vertical and horizontal jumps using an haltere type handheld with a load of 8% of the athletes' body mass (LJ; n = 12) and unloaded vertical and horizontal plyometrics (UJ; n = 11)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29016908/the-effect-of-age-on-fitness-among-female-firefighters
#7
L K Kirlin, J F Nichols, K Rusk, R A Parker, M J Rauh
Background: The physical demands of firefighting require both cardiovascular and muscular fitness, which both decline with age. While much has been published on age-related changes among male firefighters (FFs), data on female FFs are lacking. Aims: To describe cardiorespiratory fitness (CRF) and muscular fitness in a sample of female career FFs ranging in age from 25 to 60 years and determine whether ageing affects their achievement of the current recommended professional CRF standards of 12 metabolic equivalents (METs)...
September 1, 2017: Occupational Medicine
https://www.readbyqxmd.com/read/29016786/sustainability-of-outdoor-school-ground-smoking-bans-at-secondary-schools-a-mixed-method-study
#8
A D Rozema, J J P Mathijssen, M W J Jansen, J A M van Oers
Background: Although increasing numbers of countries are implementing outdoor school ground smoking bans at secondary schools, less attention is paid to the post-implementation period even though sustainability of a policy is essential for long-term effectiveness. Therefore, this study assesses the level of sustainability and examines perceived barriers/facilitators related to the sustainability of an outdoor school ground smoking ban at secondary schools. Methods: A mixed-method design was used with a sequential explanatory approach...
July 13, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28993264/sensory-mechanical-effects-of-a-dual-bronchodilator-and-its-anticholinergic-component-in-copd
#9
Denis E O'Donnell, Amany F Elbehairy, Azmy Faisal, J Alberto Neder, Katherine A Webb
This randomized, double-blind, crossover study examined the physiological rationale for using a dual long-acting bronchodilator (umeclidinium/vilanterol (UME/VIL)) versus its muscarinic-antagonist component (UME) as treatment for dyspnea and exercise intolerance in moderate COPD. After each 4-week treatment period, subjects performed pulmonary function and symptom-limited constant-work rate cycling tests with diaphragm electromyogram (EMGdi), esophageal (Pes), gastric (Pga) and transdiaphragmatic (Pdi) pressure measurements...
October 7, 2017: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/28990309/making-sense-of-frailty-an-ethnographic-study-of-the-experience-of-older-people-living-with-complex-health-problems
#10
Julie Kathryn Skilbeck, Antony Arthur, Jane Seymour
AIM: To explore how older people with complex health problems experience frailty in their daily lives. BACKGROUND: A better understanding of the personal experience of frailty in the context of fluctuating ill-health has the potential to contribute to the development of personalised approaches to care planning and delivery. DESIGN: An ethnographic study of older people, living at home, receiving support from a community matron service in a large city in the North of England...
October 9, 2017: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/28982202/effects-of-combined-aerobic-strength-training-vs-fitness-education-program-in-copd-patients
#11
Nicoletta Rinaldo, Elisabetta Bacchi, Giuseppe Coratella, Francesca Vitali, Chiara Milanese, Andrea Rossi, Federico Schena, Massimo Lanza
We compared the effects of a new physical activity education program approach (EDU), based on a periodically supervised protocol of different exercise modalities vs traditionally supervised combined strength-endurance training (CT) on health-related factors in patients with stable chronic obstructive pulmonary disease (COPD). Twenty-eight COPD patients without comorbidities were randomly assigned to receive either EDU or CT. CT was continuously supervised to combine strength-endurance training; EDU was taught to progressively increase the rate of autonomous physical activity, through different training modalities such as Nordic walking, group classes and circuit training...
October 5, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28981470/telomere-dynamics-in-immune-senescence-and-exhaustion-triggered-by-chronic-viral-infection
#12
REVIEW
Marcia Bellon, Christophe Nicot
The progressive loss of immunological memory during aging correlates with a reduced proliferative capacity and shortened telomeres of T cells. Growing evidence suggests that this phenotype is recapitulated during chronic viral infection. The antigenic volume imposed by persistent and latent viruses exposes the immune system to unique challenges that lead to host T-cell exhaustion, characterized by impaired T-cell functions. These dysfunctional memory T cells lack telomerase, the protein capable of extending and stabilizing chromosome ends, imposing constraints on telomere dynamics...
October 5, 2017: Viruses
https://www.readbyqxmd.com/read/28980321/post-exercise-recovery-of-contractile-function-and-endurance-in-humans-and-mice-is-accelerated-by-heating-and-slowed-by-cooling-skeletal-muscle
#13
Arthur J Cheng, Sarah J Willis, Christoph Zinner, Thomas Chaillou, Niklas Ivarsson, Niels Ørtenblad, Johanna T Lanner, Hans-Christer Holmberg, Håkan Westerblad
Manipulation of muscle temperature is believed to improve post-exercise recovery, with cooling being especially popular among athletes. However, it is unclear whether such temperature manipulations actually have positive effects. Accordingly, we studied the effect of muscle temperature on the acute recovery of force and fatigue resistance after endurance exercise. One hour of moderate-intensity arm cycling exercise in humans was followed by two hours recovery in which the upper arms were either heated to 38°C, not treated (33°C), or cooled to ∼15°C...
October 4, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/28979064/an-evaluation-of-multisystemic-therapy-with-australian-families
#14
Mark Porter, Leartluk Nuntavisit
This study aims to evaluate the effectiveness of the Multisystemic Therapy (MST) intervention for Australian families invloved with the Specialist Child and Adolescent Mental Health Service (CAMHS). This program was implemented within the Western Australian Department of Health in 2005, and has continually operated two small clinical teams within the Perth metropolitan area since then. This intervention was specifically chosen to improve service access, engagement, and intervention with vulnerable families having young persons with a history of significant and enduring behavioural problems...
December 2016: Australian and New Zealand Journal of Family Therapy
https://www.readbyqxmd.com/read/28968232/the-effect-of-kinesio%C3%A2-taping-on-pain-functionality-mobility-and-endurance-in-the-treatment-of-chronic-low-back-pain-a-randomized-controlled-study
#15
Fahri Köroğlu, Tuğba Kuru Çolak, M Gülden Polat
BACKGROUND: Low back pain is one of the most important causes of morbidity. OBJECTIVE: This study was designed to evaluate the effect of Kinesio® taping on pain, functionality, mobility and endurance in chronic low back pain treatment. METHODS: Patients with chronic low back pain were randomly divided into three groups. Therapeutic ultrasound, hot packs, and transcutaneous electrical nerve stimulation were applied to each group for ten sessions during two weeks, and therapeutic exercises were applied in the clinic under physiotherapist supervision starting from the sixth session...
September 22, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28966711/recovery-in-level-7-10-women-s-usa-artistic-gymnastics
#16
Stephen B Buckner, Nicholas T Bacon, Phillip A Bishop
This study assessed physical performance in women's artistic gymnastics following three variable recovery periods. Participants included fifteen female gymnasts (mean age = 13.5 ± 1.1) who had competed at USA Gymnastics (USAG) levels 7 - 10 within at least one year prior to the study. Each testing session consisted of a warm-up followed by four muscular endurance tests and one explosive maximal test. Assessments included pull-ups, leg lifts, handstand push-ups, vertical jump, and push-ups. After the performance assessments, the participants completed a typical practice session...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28966709/pilot-study-of-endurance-runners-and-brain-responses-associated-with-delay-discounting
#17
Laura E Martin, Jason-Flor V Sisante, David R Wilson, Angela A Moody, Cary R Savage, Sandra A Billinger
High levels of endurance training have been associated with potentially negative health outcomes and addictive-like symptoms such as exercise in the presence of injury and higher levels of impulsivity. This pilot study examined the relationships among self-report measures of addictive symptoms related to exercise and behavioral and neural measures of impulsivity in endurance runners. We hypothesized endurance runners would have increased preference for immediate rewards and greater activation of cognitive control regions when making decisions involving delayed rewards...
2017: International Journal of Exercise Science
https://www.readbyqxmd.com/read/28965370/a-5-year-longitudinal-study-of-association-of-maximum-bite-force-with-development-of-frailty-in-community-dwelling-older-adults
#18
Masanori Iwasaki, Yoshihara Akihiro, Naoko Sato, Misuzu Sato, Kumiko Minagawa, Mieko Shimada, Mamoru Nishimuta, Toshihiro Ansai, Yutaka Yoshitake, Takahiro Ono, Hideo Miyazaki
OBJECTIVES: To determine whether maximum bite force (MBF), an objective measure of oral function, is associated with development of frailty in community-dwelling older adults. METHODS: This prospective cohort study included community-dwelling Japanese adults aged 75 years at baseline (n = 322). Baseline MBF was measured using an electronic recording device (Occlusal Force-Meter GM10). Follow-up examinations, including physical fitness and anthropometric evaluation and structured questionnaires, were administered annually over a 5-year period to determine the incidence of frailty, which was defined by the presence of three or more of the following five components derived from the Cardiovascular Health Study: low level of mobility, low physical activity level, weakness, shrinking, and poor endurance and energy...
October 1, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28950399/effects-of-hrv-guided-vs-predetermined-block-training-on-performance-hrv-and-serum-hormones
#19
Olli-Pekka Nuuttila, Aku Nikander, Dmitry Polomoshnov, Jari Antero Laukkanen, Keijo Häkkinen
The aim of this study was to compare heart rate variability -guided (HRVG) and predetermined (PD) block periodization of high intensity aerobic training (HIT). Endurance performance, neuromuscular performance, heart rate variability (HRV) and serum hormone concentrations were measured before, in the middle and after the 8-week training period in 24 endurance trained males. Both groups improved significantly maximal treadmill velocity (Vmax) (p<0.001) and 3000 m running performance (HRVG; p<0.001 and PD; p=0...
September 26, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/28944229/targeting-trisomic-treatments-optimizing-dyrk1a-inhibition-to-improve-down-syndrome-deficits
#20
REVIEW
Megan Stringer, Charles R Goodlett, Randall J Roper
Overexpression of Dual-specificity tyrosine-phosphorylated regulated kinase 1A (DYRK1A), located on human chromosome 21, may alter molecular processes linked to developmental deficits in Down syndrome (DS). Trisomic DYRK1A is a rational therapeutic target, and although reductions in Dyrk1a genetic dosage have shown improvements in trisomic mouse models, attempts to reduce Dyrk1a activity by pharmacological mechanisms and correct these DS-associated phenotypes have been largely unsuccessful. Epigallocatechin-3-gallate (EGCG) inhibits DYRK1A activity in vitro and this action has been postulated to account for improvement of some DS-associated phenotypes that have been reported in preclinical studies and clinical trials...
September 2017: Molecular Genetics & Genomic Medicine
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