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Salivary miRNA

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https://www.readbyqxmd.com/read/28608821/expression-of-salivary-mir-203a-3p-was-related-with-oral-health-related-quality-of-life-in-healthy-volunteers
#1
Terumasa Kobayashi, Takaaki Tomofuji, Tatsuya Machida, Toshiki Yoneda, Daisuke Ekuni, Tetsuji Azuma, Takayuki Maruyama, Akiko Hirose, Manabu Morita
Oral health-related quality of life (OHRQoL) is a multidimensional construct that involves subjective evaluation of an individual's oral health. Although it is difficult to evaluate OHRQoL biologically, recently, it has been reported that circulating microRNAs (miRNAs) in several body fluids could reflect various health conditions. The aim of this pilot study was to investigate whether salivary miRNAs expression differs according to OHRQoL in healthy volunteers. Forty-six volunteers (median age, 23.0 years) were recruited, and their OHRQoL was assessed using the Japanese version of the Oral Health Impact Profile (OHIP-J)...
June 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28587347/effect-of-mesenchymal-stem-cells-on-sj%C3%A3-gren-like-mice-and-the-microrna-expression-profiles-of-splenic-cd4-t-cells
#2
Guang-Feng Ruan, Ling Zheng, Jia-Shu Huang, Wan-Xue Huang, Bang-Dong Gong, Xing-Xing Fang, Xiao-Yu Zhang, Jian-Ping Tang
Mesenchymal stem cells (MSCs) serve immuno-regulatory functions and offer a promising novel treatment for certain autoimmune diseases. The present study investigated the therapeutic effect of mice bone marrow (BM)-MSCs on mice with relatively late stage of Sjögren-like disease and the impact of BM-MSCs on the microRNA (miRNA) expression profiles of splenic CD4+ T cells. Female NOD/Ltj mice were randomized into two groups: The disease group (n=8) and the MSC-treated group (n=8). Female ICR mice served as the healthy control group (n=8)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28537673/comprehensive-analysis-of-microrna-mrna-signature-in-colon-adenocarcinoma
#3
J-Y Wang, C-L Wang, X-M Wang, F-J Liu
OBJECTIVE: The goal of our study was to identify the regulatory mechanisms of gene expression mediated by miRNAs and DNA methylation in colon adenocarcinoma (COAD). MATERIALS AND METHODS:   The miRNAs and mRNAs expression and DNA methylation data of COAD and adjacent normal tissues were obtained from The Cancer Genome Atlas (TCGA) database. Based on the differentially expressed miRNAs and mRNAs, miRNA-mRNA pairs were obtained by correlation analysis and prediction algorithms...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28521431/microrna-320a-is-downregulated-in-non-small-cell-lung-cancer-and-suppresses-tumor-cell-growth-and-invasion-by-directly-targeting-insulin-like-growth-factor-1-receptor
#4
Jianguo Wang, Chunyun Shi, Jianfei Wang, Li Cao, Li Zhong, Dongmei Wang
Accumulating evidence has demonstrated that microRNAs (miRs/miRNAs) are implicated in carcinogenesis and cancer progression, and can function as oncogenes or tumor suppressor genes in human cancer types. Previous profile studies of miRNA expression levels have revealed that miR-320a was downregulated in breast cancer, colon cancer, bladder cancer, glioblastoma and salivary adenoid cystic carcinoma. However, its expression level, potential functions and the mechanisms underlying its functions in non-small cell lung cancer (NSCLC) require further investigation...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28502067/predictive-value-of-salivary-microrna-320a-vascular-endothelial-growth-factor-receptor-2-crp-and-il-6-in-oral-lichen-planus-progression
#5
Minoo Shahidi, Soudeh Jafari, Mahmood Barati, Masoumeh Mahdipour, Mohammad Saeed Gholami
INTRODUCTION: MicroRNA (miRNA) 320a and vascular endothelial growth factor receptor 2 (VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP, dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary detections as the noninvasive tools were aimed in this study. MATERIALS AND METHODS: Histopathologic examinations were carried out to distinguish the patients with dysplastic OLP and OSCC...
May 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28473453/in-silico-target-network-analysis-of-de-novo-discovered-tick-saliva-specific-micrornas-reveals-important-combinatorial-effects-in-their-interference-with-vertebrate-host-physiology
#6
Michael Hackenberg, David Langenberger, Alexandra Schwarz, Jan Erhart, Michail Kotsyfakis
The hard tick Ixodes ricinus is an important disease vector whose salivary secretions mediate blood feeding success on vertebrate hosts, including humans. Here we describe the expression profiles and downstream analysis of de novo discovered microRNAs (miRNAs) expressed in I. ricinus salivary glands and saliva. Eleven tick-derived libraries were sequenced to produce 67,375,557 Illumina reads. De novo prediction yielded 67 bona-fide miRNAs out of which 35 are currently not present in miRBase. We report for the first time the presence of microRNAs in tick saliva obtaining furthermore molecular indicators that those might be of exosomal origin...
May 4, 2017: RNA
https://www.readbyqxmd.com/read/28470929/down-regulation-of-increased-traf6-expression-in-the-peripheral-mononuclear-cells-of-patients-with-primary-sj%C3%A3-gren-s-syndrome-by-an-ebv-eber1-specific-synthetic-single-stranded-complementary-dna-molecule
#7
Sándor Sipka, Erika Zilahi, Gábor Papp, Ji-Qing Chen, Andrea Nagy, Katalin Hegyi, József Kónya, Margit Zeher
AIM: We described earlier a simultaneously increased that the increased expression of miRNA-146a/b was accompanied by an increase in the expression of and TRAF6 and a decrease in the expression of IRAK1 genes in the peripheral mononuclear cells (PBMCs) of patients with primary Sjogren's syndrome (pSS) patients. Recently, the expression of EBV encoded. RNA (EBER) was published in the B cells of salivary glands of in pSS. In the present study, we applied an EBV-EBER1 specific synthetic single stranded complementary DNA molecule (EBV-EBER1-cDNA) to test whether any EBER1 related effect exists also in PBMCs of pSS patients...
May 3, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28447195/salivary-mir-16-mir-191-and-mir-223-intuitive-indicators-of-dominant-ovarian-follicles-in-buffaloes
#8
Prashant Singh, Naresh Golla, Pankaj Singh, Vijay Simha Baddela, Subhash Chand, Rubina Kumari Baithalu, Dheer Singh, Suneel Kumar Onteru
Estrus or sexual receptivity determination is utmost important for efficient breeding programs for female buffaloes. Prominent estrus behavioral symptoms are the result of several molecular and neuroendocrine events involving the ovary and the brain. Expression of estrus behavior is poor in buffaloes during the summer season. Hence, the discovery of biomarkers specific to the estrus stage or its related ovarian events, like the presence of dominant ovarian follicle, is helpful for developing an easy estrus determination method...
April 26, 2017: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/28377929/expression-mutation-and-amplification-status-of-egfr-and-its-correlation-with-five-mirnas-in-salivary-gland-tumours
#9
Emanuela Boštjančič, Nina Hauptman, Aleš Grošelj, Damjan Glavač, Metka Volavšek
Malignant salivary gland tumours are rare histologically and clinically heterogeneous group of tumours, missing prognostic factors and therapeutic targets. MicroRNAs (miRNAs), small noncoding RNAs, and posttranscriptional regulators of mRNA are poorly described in different subtypes of salivary gland tumours. Epidermal growth factor receptor (EGFR), an important therapeutic target and target of certain miRNAs (i.e., miR-133b), shows variable degrees of expression in salivary gland tumours. Our study included 70 parotid gland tumours of different histological subtypes...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28367077/protein-and-genetic-composition-of-four-chromatin-types-in-drosophila-melanogaster-cell-lines
#10
Lidiya V Boldyreva, Fyodor P Goncharov, Olga V Demakova, Tatyana Yu Zykova, Victor G Levitsky, Nikolay N Kolesnikov, Alexey V Pindyurin, Valeriy F Semeshin, Igor F Zhimulev
BACKGROUND: Recently, we analyzed genome-wide protein binding data for the Drosophila cell lines S2, Kc, BG3 and Cl.8 (modENCODE Consortium) and identified a set of 12 proteins enriched in the regions corresponding to interbands of salivary gland polytene chromosomes. Using these data, we developed a bioinformatic pipeline that partitioned the Drosophila genome into four chromatin types that we hereby refer to as aquamarine, lazurite, malachite and ruby. RESULTS: Here, we describe the properties of these chromatin types across different cell lines...
April 2017: Current Genomics
https://www.readbyqxmd.com/read/28349433/targeting-promoter-associated-noncoding-rna-in-vivo
#11
Gianluca Civenni
There are many classes of noncoding RNAs (ncRNAs), with wide-ranging functionalities (e.g., RNA editing, mediation of mRNA splicing, ribosomal function). MicroRNAs (miRNAs) and long ncRNAs (lncRNAs) are implicated in a wide variety of cellular processes, including the regulation of gene expression. Incorrect expression or mutation of lncRNAs has been reported to be associated with several disease conditions, such a malignant transformation in humans. Importantly, pivotal players in tumorigenesis and cancer progression, such as c-Myc, may be regulated by lncRNA at promoter level...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27981346/altered-expression-of-apoptosis-regulating-mirnas-in-salivary-gland-tumors-suggests-their-involvement-in-salivary-gland-tumorigenesis
#12
Bianca de Cássia Troncarelli de Campos Parra Flores, Silvia Vanessa Lourenço, Aline Santos Damascena, Luiz Paulo Kowaslki, Fernando Augusto Soares, Cláudia Malheiros Coutinho-Camillo
Salivary gland tumors comprise a heterogeneous group of lesions with different histological features and diverse clinical pathophysiology. They account for about 3% of all head and neck tumors. Apoptosis plays an important role during morphogenesis of glandular structures, including that of the salivary gland. Recent studies have demonstrated that several microRNAs (miRNAs) are involved in the control of apoptosis. The aim of the present study was to determine the expression of apoptosis-related miRNAs (miR-15a, miR-16, miR-17-5p, miR-20a, miR-21, miR-29, and miR-34) and their target mRNAs in 25 pleomorphic adenomas, 23 mucoepidermoid carcinomas, and 10 non-neoplastic salivary gland samples by real-time RT-PCR...
March 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/27978919/-current-advance-in-saliva-derived-exosome-study
#13
Y Zhao, L Y Yin, R R Bi, P Ma, S B Li
There is growing interest in the whole saliva as a diagnostic fluid because of the relatively simple and non-invasive collection. Research on salivary proteomic and genomic has greatly facilitated the diagnosis and therapy of oral diseases, also revealed the molecular mechanism of the diseases. Saliva-derived exosome as a new source, with various molecular constituents of their cells of origin, including proteins, mRNA and miRNA might serve as potential biomarker. This article reviews the biological properties of saliva exosome, its separation and other aspects associated with disease...
December 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27832115/the-potential-use-of-salivary-mirnas-as-promising-biomarkers-for-detection-of-cancer-a-meta-analysis
#14
Yuanjie Ding, Qing Ma, Fen Liu, Lei Zhao, Wenqiang Wei
BACKGROUND: Accumulating evidence has demonstrated that microRNAs (miRNAs) could serve as promising molecular biomarkers for cancer detection. This study aims to systematically assess the diagnostic performance of salivary miRNAs in detection of cancer through a comprehensive meta-analysis. METHODS: Eligible studies were identified using PubMed and other computerized databases up to October 31, 2015, supplemented by a manual search of references from retrieved articles...
2016: PloS One
https://www.readbyqxmd.com/read/27802200/modern-molecular-biomarkers-of-head-and-neck-cancer-part-i-epigenetic-diagnostics-and-prognostics-systematic-review
#15
REVIEW
Gintaras Juodzbalys, David Kasradze, Marco Cicciù, Aurimas Sudeikis, Laurynas Banys, Pablo Galindo-Moreno, Zygimantas Guobis
INTRODUCTION: Nearly half of the head and neck cancer cases are diagnosed in late stages. Traditional screening modalities have many disadvantages. The aim of the present article was to review the scientific literature about novel head and neck cancer diagnostics - epigenetic biomarkers. EVIDENCE ACQUISITION: A comprehensive review of the current literature was conducted according to the PRISMA guidelines by accessing the NCBI PubMed database. Authors conducted the search of articles in English language published from 2004 to 2015...
2016: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/27573701/mir%C3%A2-1246-and-mir%C3%A2-4644-in-salivary-exosome-as-potential-biomarkers-for-pancreatobiliary-tract-cancer
#16
Tatsuya Machida, Takaaki Tomofuji, Takayuki Maruyama, Toshiki Yoneda, Daisuke Ekuni, Tetsuji Azuma, Hisataka Miyai, Hirofumi Mizuno, Hironari Kato, Koichiro Tsutsumi, Daisuke Uchida, Akinobu Takaki, Hiroyuki Okada, Manabu Morita
Pancreatobiliary tract cancer is a highly fatal cancer. Detection of pancreatobiliary tract cancer is difficult because it lacks typical clinical symptoms and because of its anatomical location. Biomarker discovery is therefore important to detect pancreatobiliary tract cancer in its early stage. A study demonstrated that expression levels of miR‑1246, miR‑3976, miR‑4306, and miR‑4644 in serum exosomes were higher in pancreatic cancer patients than these levels in healthy control participants. Supposing that microRNA (miRNA) expression profiles in saliva are similar to those in serum, four miRNAs (miR‑1246, miR‑3976, miR‑4306, and miR‑4644) in salivary exosomes may also be useful for detection of pancreatobiliary tract cancer...
October 2016: Oncology Reports
https://www.readbyqxmd.com/read/27489606/inflammatory-cytokines-interleukin-1%C3%AE-and-tumour-necrosis-factor-%C3%AE-novel-biomarkers-for-the-detection-of-periodontal-diseases-a-literature-review
#17
REVIEW
Francisco Isaac Fernandes Gomes, Maria Gerusa Brito Aragão, Francisco Cesar Barroso Barbosa, Mirna Marques Bezerra, Vicente de Paulo Teixeira Pinto, Hellíada Vasconcelos Chaves
OBJECTIVES: The article aims to discuss the IL-1β and TNF-α potential use as salivary biomarkers of periodontal diseases pathogenesis and progression. MATERIAL AND METHODS: This literature review has been registered in PROSPERO database with following number: CRD42016035729. Data investigation was performed on PubMed database as the main source of studies. The following search terms were used: "salivary biomarkers", "periodontal diseases", "TNF-alpha", "Interleukin-1 beta"...
April 2016: Journal of Oral & Maxillofacial Research
https://www.readbyqxmd.com/read/27429973/micrornas-as-salivary-markers-for-periodontal-diseases-a-new-diagnostic-approach
#18
REVIEW
Gerhard Schmalz, Simin Li, Ralph Burkhardt, Sven Rinke, Felix Krause, Rainer Haak, Dirk Ziebolz
The aim of this review is to discuss current findings regarding the roles of miRNAs in periodontal diseases and the potential use of saliva as a diagnostic medium for corresponding miRNA investigations. For periodontal disease, investigations have been restricted to tissue samples and five miRNAs, that is, miR-142-3p, miR-146a, miR-155, miR-203, and miR-223, were repeatedly validated in vivo and in vitro by different validation methods. Particularly noticeable are the small sample sizes, different internal controls, and different case definitions of periodontitis in in vivo studies...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27193612/isolation-of-human-salivary-extracellular-vesicles-by-iodixanol-density-gradient-ultracentrifugation-and-their-characterizations
#19
Kazuya Iwai, Tamiko Minamisawa, Kanako Suga, Yasutomo Yajima, Kiyotaka Shiba
Diagnostic methods that focus on the extracellular vesicles (EVs) present in saliva have been attracting great attention because of their non-invasiveness. EVs contain biomolecules such as proteins, messenger RNA (mRNA) and microRNA (miRNA), which originate from cells that release EVs, making them an ideal source for liquid biopsy. Although there have been many reports on density-based fractionation of EVs from blood and urine, the number of reports on EVs from saliva has been limited, most probably because of the difficulties in separating EVs from viscous saliva using density gradient centrifugation...
2016: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/27105825/salivary-mirna-profiles-identify-children-with-autism-spectrum-disorder-correlate-with-adaptive-behavior-and-implicate-asd-candidate-genes-involved-in-neurodevelopment
#20
Steven D Hicks, Cherry Ignacio, Karen Gentile, Frank A Middleton
BACKGROUND: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder that lacks adequate screening tools, often delaying diagnosis and therapeutic interventions. Despite a substantial genetic component, no single gene variant accounts for >1 % of ASD incidence. Epigenetic mechanisms that include microRNAs (miRNAs) may contribute to the ASD phenotype by altering networks of neurodevelopmental genes. The extracellular availability of miRNAs allows for painless, noninvasive collection from biofluids...
2016: BMC Pediatrics
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