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https://www.readbyqxmd.com/read/29656297/reducing-mineral-and-vitamin-deficiencies-through-biofortification-progress-under-harvestplus
#1
Howarth Bouis
Fundamentally, the prevalence of mineral and vitamin deficiencies is high in developing countries due to the fact that agricultural systems do not produce sufficient foods rich in minerals and vitamins. Biofortification involves breeding staple food crops to increase their micronutrient content, targeting staple foods widely consumed by low-income families globally. In so doing, biofortification contributes to solving the underlying problem of mineral and vitamin deficiencies by increasing the amount of iron, zinc, and provitamin A produced by food systems...
April 13, 2018: World Review of Nutrition and Dietetics
https://www.readbyqxmd.com/read/29655753/detection-of-fe-iii-edta-by-using-photoluminescent-carbon-dot-with-the-aid-of-f-ion
#2
Nan Wang, Huijuan Chai, Xuelin Dong, Qian Zhou, Lihua Zhu
Iron(III) ethylenediaminetetraacetate (Fe(III)EDTA) is widely used in iron fortification for reducing iron deficiency, and its determination is urgently needed. The present work developed a fluorescent method to straightforwardly determine Fe(III)EDTA by using photoluminescent carbon dots (C-dots) with the aid of F- ions as the masking agent of free Fe3+ ions. In the presence of F- ions, only Fe(III)EDTA selectively quenched the photoluminescence of C-dots, and both Fe3+ and Fe2+ as well as other carboxylic acids have no effect on the emission of C-dots...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29644949/extrinsic-iron-from-soil-contributes-to-hb-regeneration-of-anaemic-rats-implications-for-foods-contaminated-with-soil-iron
#3
Habtamu Guja, Kaleab Baye
Contamination of foods with extrinsic (soil) Fe is common in developing countries. However, the bioavailability of this extrinsic Fe and the extent to which it contributes to Fe nutrition remains unknown. The present study compared the bioavailability of laboratory- and field-threshed teff (Eragrostisis tef (Zucc) Trotter) to evaluate the bioavailablity of extrinsic soil Fe that resulted from the traditional threshing of the staple grain. Using sequential extraction, Fe was fractionated and its solubility was evaluated...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29644197/clinical-spectrum-of-autoerythrocyte-sensitization-syndrome-a-series-of-five-cases
#4
Nandakishore Singh Thokchom, D Pradeepa, N A Bishurul Hafi, Kapila Verma
Autoerythrocyte sensitization syndrome (Gardner Diamond syndrome or GDS) is a rare syndrome characterized by painful and spontaneous purpura commonly affecting adult women, and is mostly associated with psychiatric illness. Diagnosis is mainly based on clinical presentation, exclusion of other simulating diseases, and psychiatric evaluation. Only few cases have been reported till date. We report five cases of spontaneous purpura with a normal investigation profile, except for iron deficiency anemia in 1 patient, of which three had associated underlying psychiatric illness...
March 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29627385/regulation-of-yeast-fatty-acid-desaturase-in-response-to-iron-deficiency
#5
Antonia María Romero, Tania Jordá, Nicolas Rozès, María Teresa Martínez-Pastor, Sergi Puig
Unsaturated fatty acids (UFA) are essential components of phospholipids that greatly contribute to the biophysical properties of cellular membranes. Biosynthesis of UFAs relies on a conserved family of iron-dependent fatty acid desaturases, whose representative in the model yeast Saccharomyces cerevisiae is Ole1. OLE1 expression is tightly regulated to adapt UFA biosynthesis and lipid bilayer properties to changes in temperature, and in UFA or oxygen availability. Despite iron deficiency being the most extended nutritional disorder worldwide, very little is known about the mechanisms and the biological relevance of fatty acid desaturases regulation in response to iron starvation...
April 5, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29626380/the-arbuscular-mycorrhizal-fungus-rhizophagus-irregularis-uses-a-reductive-iron-assimilation-pathway-for-high-affinity-iron-uptake
#6
Elisabeth Tamayo, Simon A B Knight, Ascensión Valderas, Andrew Dancis, Nuria Ferrol
Arbuscular mycorrhizal (AM) fungi can improve iron (Fe) acquisition of their host plants. Here, we report a characterization of two components of the high-affinity reductive Fe uptake system of Rhizophagus irregularis, the ferric reductase (RiFRE1) and the high affinity Fe permeases (RiFTR1-2). In the extraradical mycelia (ERM), Fe deficiency induced activation of a plasma membrane-localized ferric reductase, an enzyme that reduces Fe(III) sources to the more soluble Fe(II). Yeast mutant complementation assays showed that RiFRE1 encodes a functional ferric reductase and RiFTR1 an iron permease...
April 6, 2018: Environmental Microbiology
https://www.readbyqxmd.com/read/29626126/apto-253-is-a-new-addition-to-the-repertoire-of-drugs-that-can-exploit-dna-brca1-2-deficiency
#7
Cheng-Yu Tsai, Si Sun, Hongying Zhang, Andrea Local, Yongxuan Su, Larry A Gross, William G Rice, Stephen B Howell
APTO-253 is a small molecule with anti-proliferative activity against cell lines derived from a wide range of human malignancies. We sought to determine the mechanisms of action and basis for resistance to APTO-253 so as to identify synthetic lethal interactions that can guide combination studies. The cellular pharmacology of APTO-253 was analyzed in Raji lymphoma cells and a subline selected for resistance (Raji/253R). Using LC/MS/ESI analysis, APTO-253 was found to convert intracellularly to a complex containing one molecule of iron and three molecules of APTO-253 [Fe(253)3]...
April 6, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29626044/efficacy-of-iron-supplementation-on-fatigue-and-physical-capacity-in-non-anaemic-iron-deficient-adults-a-systematic-review-of-randomised-controlled-trials
#8
Brett L Houston, Daryl Hurrie, Jeff Graham, Brittany Perija, Emily Rimmer, Rasheda Rabbani, Charles N Bernstein, Alexis F Turgeon, Dean A Fergusson, Donald S Houston, Ahmed M Abou-Setta, Ryan Zarychanski
OBJECTIVE: Iron supplementation in iron-deficiency anaemia is standard practice, but the benefits of iron supplementation in iron-deficient non-anaemic (IDNA) individuals remains controversial. Our objective is to identify the effects of iron therapy on fatigue and physical capacity in IDNA adults. DESIGN: Systematic review and meta-analysis of randomised controlled trials (RCTs). SETTING: Primary care. PARTICIPANTS: Adults (≥18 years) who were iron deficient but non-anaemic...
April 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29626026/dilated-cardiomyopathy-as-the-first-presentation-of-coeliac-disease-association-or-causation
#9
Peysh Patel, Fraser Smith, Niamh Kilcullen, Nigel Artis
Global ventricular impairment is a frequent presentation in clinical practice, but dissection of causative mechanisms from clinical associations is challenging. We present the case of a 19-year-old man who presented with dilated cardiomyopathy as the first presentation of coeliac disease. The manifestation of iron deficiency anaemia prompted gastroenterology input and enabled accurate diagnosis. It is unclear whether coeliac disease was simply coexistent or directly implicated in pathophysiology. Mechanisms may relate to nutritional deficiencies or autoimmune myocarditis arising from cross-reactivity...
March 2018: Clinical Medicine: Journal of the Royal College of Physicians of London
https://www.readbyqxmd.com/read/29623817/restless-legs-syndrome-in-patients-infected-with-helicobacter-pylori
#10
Farzaneh Rezvani, Mohammad Sayadnasiri, Omid Rezaei
Objective Although the etiology of restless legs syndrome (RLS) is yet to be discovered, some studies have mentioned the effect of infectious diseases in occurrence of RLS. This study aims to determine the association between common Helicobacter pylori (H. pylori) infection and occurrence of RLS. Methods In this descriptive analytical cross-sectional study, patients with RLS who were referred to the Internal Medicine Clinic of Fayazbakhsh Hospital in Tehran from September to December 2016 were evaluated. Patients with underlying diseases that would lead to secondary RLS were excluded from the study...
April 6, 2018: Neurological Research
https://www.readbyqxmd.com/read/29623423/clinical-and-genetic-aspects-of-defects-in-the-mitochondrial-iron-sulfur-cluster-synthesis-pathway
#11
REVIEW
A V Vanlander, R Van Coster
Iron-sulfur clusters are evolutionarily conserved biological structures which play an important role as cofactor for multiple enzymes in eukaryotic cells. The biosynthesis pathways of the iron-sulfur clusters are located in the mitochondria and in the cytosol. The mitochondrial iron-sulfur cluster biosynthesis pathway (ISC) can be divided into at least twenty enzymatic steps. Since the description of frataxin deficiency as the cause of Friedreich's ataxia, multiple other deficiencies in ISC biosynthesis pathway have been reported...
April 5, 2018: Journal of Biological Inorganic Chemistry: JBIC
https://www.readbyqxmd.com/read/29622900/unsuspected-small-bowel-crohn-s-disease-in-elderly-patients-diagnosed-by-video-capsule-endoscopy
#12
Che-Yung Chao, Carl Frederic Duchatellier, Ernest G Seidman
Background: Video capsule endoscopy (VCE) is increasingly performed among the elderly for obscure bleeding. Our aim was to report on the utility of VCE to uncover unsuspected Crohn's disease (CD) in elderly patients. Methods: Retrospective review of VCE performed in elderly patients (≥70 y) at a tertiary hospital (2010-2015). All underwent prior negative bidirectional endoscopies. CD diagnosis was based on consistent endoscopic findings, exclusion of other causes, and a Lewis endoscopic score (LS) > 790 (moderate-to-severe inflammation)...
2018: Diagnostic and Therapeutic Endoscopy
https://www.readbyqxmd.com/read/29622861/management-of-iron-deficiency-anemia-in-pregnancy-in-india
#13
Rimpy Tandon, Arihant Jain, Pankaj Malhotra
Iron deficiency anemia (IDA) continues to be the commonest etiology of anemia in pregnancy. The prevalence of iron deficiency (ID) in pregnant Indian women is amongst the highest in the world. Untreated iron deficiency (ID) has significant adverse feto-maternal consequences. Plethora of investigations are available for diagnosis of IDA, each having specific advantages and disadvantages when used in the pregnancy setting. Therapy for ID includes dietary modification, oral iron supplementation, intravenous iron and blood transfusion...
April 2018: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/29621996/magnitude-and-factors-associated-with-adherence-to-iron-folic-acid-supplementation-among-pregnant-women-in-eritrean-refugee-camps-northern-ethiopia
#14
Mekdemariam Getachew, Mebrahtu Abay, Hiwet Zelalem, Tirhas Gebremedhin, Teklit Grum, Alemayehu Bayray
BACKGROUND: Globally, anemia is a public health problem affecting the life of more than two billion people. Pregnant women are at high risk of iron deficiency anemia due to increased nutrient requirement during pregnancy. Iron-folic acid supplementation is the main strategy for prevention and control of iron deficiency anemia and its effectiveness depends on adherence to Iron-Folic Acid tablets. In the refugee camps of Ethiopia, despite the efforts made to reduce iron deficiency anemia during pregnancy, information about adherence to iron-folic acid supplementation and its associated factors are lacking...
April 5, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29621767/understanding-iron-deficiency-and-exercise-looking-beyond-ferritin
#15
Richard J Burden, Charles R Pedlar
No abstract text is available yet for this article.
April 5, 2018: Acta Haematologica
https://www.readbyqxmd.com/read/29621265/optimum-strata-boundaries-and-sample-sizes-in-health-surveys-using-auxiliary-variables
#16
Karuna Garan Reddy, Mohammad G M Khan, Sabiha Khan
Using convenient stratification criteria such as geographical regions or other natural conditions like age, gender, etc., is not beneficial in order to maximize the precision of the estimates of variables of interest. Thus, one has to look for an efficient stratification design to divide the whole population into homogeneous strata that achieves higher precision in the estimation. In this paper, a procedure for determining Optimum Stratum Boundaries (OSB) and Optimum Sample Sizes (OSS) for each stratum of a variable of interest in health surveys is developed...
2018: PloS One
https://www.readbyqxmd.com/read/29620435/beyond-self-monitored-plasma-glucose-and-hba1c-the-role-of-non-traditional-glycaemic-markers-in-gestational-diabetes-mellitus
#17
Neuza Mendes, Rogério Tavares Ribeiro, Fátima Serrano
Strict glycaemic management is the cornerstone of metabolic control in gestational diabetes mellitus (GDM). Current monitoring standards involve self-monitoring plasma glucose (SMBG) and haemoglobin A1c (HbA1c). However, both have important limitations. SMBG only reflects instantaneous blood glucose and the inconvenience of self-collecting blood frequently results in poor compliance. HbA1c provides information on blood glucose levels from the previous 2 to 3 months and it is influenced by iron-deficient states, common during pregnancy...
April 5, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29619936/intravenous-iron-treatment-in-the-puerperium
#18
Charlotte Holm
Iron deficiency and anaemia in the puerperium are associated with several important clinical consequences, most prominently physical fatigue. Current treatment practice with oral iron supplementation is associated with gastrointestinal side-effects and subsequent poor compliance. Red blood cell transfusion is also widely used to treat severe postpartum anaemia, though accumulating evidence questions its risk-benefit ratio. Intravenous iron has in previous studies been associated with fast improvement of haemoglobin and iron biochemical markers in the treatment of postpartum anaemia, but there is a lack of studies on patient reported outcomes...
April 2018: Danish Medical Journal
https://www.readbyqxmd.com/read/29619914/iron-deficiency-after-bariatric-surgery-what-is-the-real-problem
#19
Nele Steenackers, Bart Van der Schueren, Ann Mertens, Matthias Lannoo, Tara Grauwet, Patrick Augustijns, Christophe Matthys
The growing prevalence of obesity explains the rising interest in bariatric surgery. Compared with non-surgical treatment options, bariatric surgery results in greater and sustained improvements in weight loss, obesity associated complications, all-cause mortality and quality of life. These encouraging metabolic and weight effects come with a downside, namely the risk of nutritional deficiencies. Particularly striking is the risk to develop iron deficiency. Postoperatively, the prevalence of iron deficiency varies between 18 and 53 % after Roux-en-Y gastric bypass and between 1 and 54 % after sleeve gastrectomy...
April 5, 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29618428/decreased-activity-of-glutathione-peroxidase-with-oral-ferrous-iron-administration-a-cause-of-oxidative-stress
#20
Shamaila Khalid, Fuad Shaikh, Sara Moeen
Iron deficiency anemia (IDA) during pregnancy not only results in the disturbance of hematological parameters but has been found to be an additional cause of oxidative stress (OS). Moreover, oral iron for IDA during pregnancy has been found to worsen the condition. Present study aims to detect any alteration in glutathione peroxidase (GSH-Px) activity as an enzymatic anti-oxidant and its association with oral iron supplements. For study, 40 anemic pregnant women were prescribed with 200mg ferrous sulphate for 12 weeks (wks)...
March 2018: Pakistan Journal of Pharmaceutical Sciences
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