keyword
MENU ▼
Read by QxMD icon Read
search

Iron deficient

keyword
https://www.readbyqxmd.com/read/29909502/increased-ngal-level-associated-with-iron-store-in-chronic-kidney-disease-with-anemia
#1
Daijun Xiang, Xiuying Wang, Peipei Liu, Yuling Pan, Qian Zhang, Xiuping Chi, Ying Jing, Xinxin Duan, Qiaozhen Wei, Jianan Wang, Mianyang Li, Chengbin Wang
An iron scarcity often occurs in chronic kidney disease (CKD). Neutrophil gelatinase-associated lipocalin (NGAL), a biomarker of acute kidney injury, is associated with iron metabolism. The present study determined the association between serum NGAL and iron status in chronic kidney disease with anemia. A total of 154 adult CKD patients were divided into anemia and without anemia groups. The anemia groups were further subdivided into two groups based on the presence or absence of iron deficiency, defined as a transferrin saturation (TSAT) < 20%...
June 16, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29908648/maternal-perceived-stress-during-pregnancy-increases-risk-for-low-neonatal-iron-at-delivery-and-depletion-of-storage-iron-at-one-year
#2
Danielle N Rendina, Sharon E Blohowiak, Christopher L Coe, Pamela J Kling
OBJECTIVE: To investigate the impact of maternal stress during pregnancy on newborn iron and stage 1 iron deficiency at 1 year of age. STUDY DESIGN: In total, 245 mothers and their newborn infants (52% male; 72% white) were recruited at the Meriter Hospital Birthing Center on the basis of known risk factors for iron deficiency. Umbilical cord blood hemoglobin and zinc protoporphyrin/heme (ZnPP/H) were determined to evaluate erythrocyte iron and plasma ferritin was determined to reflect storage iron...
June 14, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29908199/establishment-of-a-cell-model-of-x-linked-sideroblastic-anemia-using-genome-editing
#3
Kiriko Kaneko, Yoshiko Kubota, Kazumi Nomura, Haruka Hayashimoto, Taisei Chida, Naoto Yoshino, Marina Wayama, Katsutoshi Ogasawara, Yukio Nakamura, Ikuo Tooyama, Kazumichi Furuyama
ALAS2 gene mutations cause X-linked sideroblastic anemia. The presence of ring sideroblasts in a patient's bone marrow is the hallmark of sideroblastic anemia, but the precise mechanisms underlying sideroblast formation are largely unknown. Using a genome editing system, a mutation was introduced in the erythroid-specific enhancer of the ALAS2 gene in HUDEP2 cells, which were derived from human umbilical stem cells and can produce erythrocytes. The established cell line, termed HA2low, expressed less ALAS2 mRNA than did wild-type cells, even after erythroid differentiation...
June 13, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29907852/predictors-of-anemia-and-iron-status-at-birth-in-neonates-born-to-women-carrying-multiple-fetuses
#4
Yuan Ru, Eva K Pressman, Ronnie Guillet, Philip J Katzman, Stephen J Bacak, Kimberly O O'Brien
BACKGROUND: Iron (Fe) status of neonates born to women carrying multiple fetuses might be compromised as a consequence of the high prevalence of maternal Fe deficiency and anemia coupled with an increased risk of preterm birth. This study aimed to characterize and identify determinants of anemia in this neonatal population. METHODS: Umbilical cord blood obtained from 183 neonates was utilized to assess hemoglobin (Hb), ferritin (SF), soluble transferrin receptor (sTfR), hepcidin, serum Fe, erythropoietin, folate, vitamin B-12, C-reactive protein, and interleukin-6...
June 15, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29907846/greater-blood-volume-and-hb-mass-in-obese-women-quantified-by-the-carbon-monoxide-rebreathing-method-affects-interpretation-of-iron-biomarkers-and-iron-requirements
#5
Ana C Cepeda-Lopez, Michael B Zimmermann, Sophia Wussler, Alida Melse-Boonstra, Nicole Naef, Sandro Manuel Mueller, Marco Toigo, Isabelle Herter-Aeberli
BACKGROUND/OBJECTIVE: Iron deficiency (ID) is common in overweight and obese individuals (OW/OB) but the mechanism is uncertain. Greater blood volume (BV) in OW/OB may increase hemoglobin (Hb) mass and iron requirements, and confound iron biomarkers by hemodilution. Quantification of BV/PV changes in OW/OB is challenging and a formula to estimate BV/PV based on anthropometric indices would be valuable. In normal weight (NW) and OW/OB women, we aimed at: (1) measure BV and assess whether differences in BV affect concentrations and total circulating mass of Hb and iron biomarkers; (2) develop an algorithm describing BV in OW/OB...
June 15, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29906288/a-mfs-like-plasma-membrane-transporter-required-for-leishmania-virulence-protects-the-parasites-from-iron-toxicity
#6
Maria Fernanda Laranjeira-Silva, Wanpeng Wang, Tamika K Samuel, Fernando Y Maeda, Vladimir Michailowsky, Iqbal Hamza, Zhongchi Liu, Norma W Andrews
Iron is essential for many cellular processes, but can generate highly toxic hydroxyl radicals in the presence of oxygen. Therefore, intracellular iron accumulation must be tightly regulated, by balancing uptake with storage or export. Iron uptake in Leishmania is mediated by the coordinated action of two plasma membrane proteins, the ferric iron reductase LFR1 and the ferrous iron transporter LIT1. However, how these parasites regulate their cytosolic iron concentration to prevent toxicity remains unknown...
June 15, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29905580/iron-therapy-for-managing-anaemia-in-chronic-kidney-disease
#7
Iain C Macdougall
PURPOSE OF REVIEW: Iron deficiency is a major contributory cause to the development of anaemia in chronic kidney disease (CKD), and thus, iron replacement therapy plays a critical role in the management of this condition. The two main routes for administering iron are oral and intravenous, and there have been a number of new publications relevant to both routes of administration. RECENT FINDINGS: Recent developments on the topic of iron management in CKD include the introduction of new oral iron preparations, as well as two recent meta-analyses on iron therapy in CKD (one on oral versus intravenous iron, and one on high- versus low-dose intravenous iron in haemodialysis patients)...
June 13, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29903777/pancytopenia-in-an-adult-patient-with-thiamine-responsive-megaloblastic-anaemia
#8
Virginie Moulin, Francesco Grandoni, Julien Castioni, Henri Lu
Thiamine-responsive megaloblastic anaemia (TRMA) is a syndrome associated with megaloblastic anaemia, diabetes mellitus and sensorineural deafness, due to mutations in the SLC19A2 gene, which codes for a thiamine carrier protein. Oral thiamine supplementation is the main treatment. We report the case of a 25-year-old woman known for TRMA, who presented with pancytopenia (haemoglobin 7.6 g/dL, leucocytes 2.9×109 /L, thrombocytes 6×109 /L) revealed by dyspnoea. Investigations excluded coagulopathy, a recent viral infection, vitamin and iron deficiencies, and a malignant process...
June 14, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29903686/do-specialized-bariatric-multivitamins-lower-deficiencies-after-rygb
#9
Wendy Schijns, Lisanne T Schuurman, Alida Melse-Boonstra, Cees J H M van Laarhoven, Frits J Berends, Edo O Aarts
BACKGROUND: One of the side effects of bariatric surgery is the risk of vitamin and mineral deficiencies. Vitamin B12, vitamin D, folate, and iron deficiencies are especially common among Roux-en-Y gastric bypass patients. OBJECTIVE: To examine the effectiveness of a specialized multivitamin supplement for Roux-en-Y gastric bypass patients on deficiencies the first 3 years postoperatively, retrospectively in a large, prospectively collected cohort. SETTING: Large specialized bariatric hospital...
April 3, 2018: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29903176/-follow-up-study-on-diet-folic-acid-and-iron-status-in-358-cases-of-uighur-pregnant-women-from-xinjiang-kashi
#10
Tuerxunjiang Maimaitiming, Xiaojun Wang, Camila Tuerxunjiang, Yanqiong Yang, Dilihuomaer Wuerkaixi, Jinfen Pu, Li Wang, Liuqianzi Yan
OBJECTIVE: To understand the dietary intake situation of Uighur pregnant women, investigate folic acid level and its influencing factors, to provide evidence for health education of maternal nutrition and implementation of proper nutrition, balanceddiet guidance. METHODS: 358 cases of Uighur trimester pregnant women for the study, took the method of 3 d 24 h dietary recall to survey their dietary and collect blood samples. The Hb was detected by the cyanide methemoglobinmethod...
July 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
https://www.readbyqxmd.com/read/29902966/transcriptional-and-physiological-analyses-of-short-term-iron-deficiency-response-in-apple-seedlings-provide-insight-into-the-regulation-involved-in-photosynthesis
#11
Yan-Xiu Wang, Ya Hu, Yan-Fang Zhu, Abdul Wahid Baloch, Xu-Mei Jia, Ai-Xia Guo
BACKGROUND: Iron (Fe) is an essential micronutrient for plants. Utilization of Fe deficiency-tolerant rootstock is an effective strategy to prevent Fe deficiency problems in fruit trees production. Malus halliana is an apple rootstock that is resistant to Fe deficiency; however, few molecular studies have been conducted on M. halliana. RESULTS: To evaluate short-term molecular response of M. halliana leaves under Fe deficiency condition, RNA sequencing (RNA-Seq) analyses were conducted at 0 (T1), 0...
June 15, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29902439/the-impact-of-dietary-transition-metals-on-host-bacterial-interactions
#12
REVIEW
Christopher A Lopez, Eric P Skaar
Transition metals are required cofactors for many proteins that are critical for life, and their concentration within cells is carefully maintained to avoid both deficiency and toxicity. To defend against bacterial pathogens, vertebrate immune proteins sequester metals, in particular zinc, iron, and manganese, as a strategy to limit bacterial acquisition of these necessary nutrients in a process termed "nutritional immunity." In response, bacteria have evolved elegant strategies to access metals and counteract this host defense...
June 13, 2018: Cell Host & Microbe
https://www.readbyqxmd.com/read/29901736/prenatal-and-postnatal-supplementation-with-lipid-based-nutrient-supplements-reduces-anemia-and-iron-deficiency-in-18-month-old-bangladeshi-children-a-cluster-randomized-effectiveness-trial
#13
Susana L Matias, Malay K Mridha, Rebecca T Young, Md Showkat A Khan, Zakia Siddiqui, Md Barkat Ullah, Stephen A Vosti, Kathryn G Dewey
Background: Anemia, iron deficiency (ID), and iron deficiency anemia (IDA) among young children are public health concerns in developing countries. Objective: We evaluated the effects of small-quantity lipid-based nutrient supplements (LNSs) and micronutrient powder (MNP) on anemia, ID, and IDA in 18-mo-old Bangladeshi children. Methods: We enrolled 4011 pregnant women in a cluster-randomized effectiveness trial with 4 arms-1) LNS-LNS: LNSs (including 20 mg Fe) for women daily during pregnancy and 6 mo postpartum and LNSs (including 9 mg Fe) for children daily from 6 to 24 mo of age (LNS-C); 2) IFA-LNS: iron (60 mg) and folic acid (IFA) for women daily during pregnancy and every other day for 3 mo postpartum and LNS-C for children; 3) IFA-MNP: IFA for women, and MNP (including 10 mg Fe) for children daily from 6 to 24 mo; and 4) IFA-Control: IFA for women and no child supplement...
June 13, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29898820/hematinic-deficiencies-and-hyperhomocysteinemia-in-gastric-parietal-cell-antibody-positive-or-gastric-and-thyroid-autoantibodies-negative-behcet-s-disease-patients
#14
Chun-Pin Chiang, Yu-Hsueh Wu, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Andy Sun
BACKGROUND/PURPOSE: Our previous study found that 9 of 63 recurrent aphthous stomatitis (RAS)/Behcet's disease (BD) patients have serum gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA positivity or RAS/BD itself was a significant factor causing hematinic deficiencies and hyperhomocysteinemia in GPCA-positive RAS/BD (GPCA+ RAS/BD) or gastric and thyroid autoantibodies-negative RAS/BD (Abs- RAS/BD) patients. METHODS: The mean blood hemoglobin (Hb), iron, vitamin B12, folic acid, and homocysteine levels were measured and compared between any two of three groups of 9 GPCA+ RAS/BD patients, 41 Abs- RAS/BD patients, and 126 healthy control subjects...
June 10, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29897579/iron-deficiency-anemia-and-low-vitamin-b-12-serostatus-in-middle-childhood-are-associated-with-behavior-problems-in-adolescent-boys-results-from-the-bogot%C3%A3-school-children-cohort
#15
Sonia L Robinson, Constanza Marín, Henry Oliveros, Mercedes Mora-Plazas, Blair J Richards, Betsy Lozoff, Eduardo Villamor
Background: Iron deficiency (ID) in infancy is related to subsequent behavior problems. The effects of micronutrient status in middle childhood are uncertain. Objective: The aim of the study was to examine the associations of micronutrient status biomarkers in middle childhood with externalizing and internalizing behavior problems in adolescence. Methods: We assessed whether ID (ferritin <15 µg/L), anemia (hemoglobin <12.7 g/dL), or blood concentrations of zinc, vitamins A and B-12, and folate at ages 5-12 y were associated with externalizing or internalizing behavior problems in adolescence in 1042 schoolchildren from Bogotá, Colombia...
April 20, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29896207/flagella-associated-wdr-containing-protein-crfap89-regulates-growth-and-lipid-accumulation-in-chlamydomonas-reinhardtii
#16
Qiulan Luo, Wenwen Song, Yajun Li, Chaogang Wang, Zhangli Hu
WD40-repeat (WDR) domain-containing proteins are subunits of multi-protein E3 ligase complexes regulating various cellular and developmental activities in eukaryotes. Chlamydomonas reinhardtii serves as a model organism to study lipid metabolism in microalgae. Under nutrition deficient conditions, C. reinhardtii accumulates lipids for survival. The proteins in C. reinhardtii flagella have diverse functions, such as controlling the motility and cell cycle, and environment sensing. Here, we characterized the function of CrFAP89, a flagella-associated WDR-containing protein, which was identified from C...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29895660/normalizing-hepcidin-predicts-tmprss6-mutation-status-in-patients-with-chronic-iron-deficiency
#17
Matthew M Heeney, Dongjing Guo, Luigia De Falco, Dean R Campagna, Gordana Olbina, Paige P-C Kao, Klaus Schmitz-Abe, Fedik Rahimov, Patrick Gutschow, Keith Westerman, Vaughn Ostland, Tracy Jackson, Robert E Klaassen, Kyriacos Markianos, Karin E Finberg, Achille Iolascon, Mark Westerman, Wendy B London, Mark D Fleming
No abstract text is available yet for this article.
June 12, 2018: Blood
https://www.readbyqxmd.com/read/29895379/evaluation-of-the-uptake-storage-and-cell-effects-of-nano-iron-in-enterocyte-like-cell-models
#18
Daniel Turiel-Fernández, Jörg Bettmer, Maria Montes-Bayón
The therapy with nanocompounds is widely used to treat Fe deficiency and an emerging trend to inhibit tumor growth. The present work aims to address the management of different FeONP, comparing sucrose covered FeONP and Fe nanoparticles in the form of the ferritin with non-particulated inorganic Fe (II) by enterocytes-like colon cancer cell lines (Caco-2 and HT-29). Iron uptake results revealed significantly higher Fe incorporation in the case of nanoparticulated Fe, first in the form of FeONP and second in the form of ferritin with respect to inorganic Fe (II)...
September 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29895376/effect-of-various-calcium-salts-on-non-heme-iron-bioavailability-in-fasted-women-of-childbearing-age
#19
Valeria Candia, Israel Ríos-Castillo, Frank Carrera-Gil, Berta Vizcarra, Manuel Olivares, Sotiris Chaniotakis, Fernando Pizarro
INTRODUCTION: Micronutrient deficiencies are one of the most important public health issues worldwide and iron (Fe) deficiency anemia is the most prevalent micronutrient deficiency. Iron deficiency often coexists with calcium deficiency and iron and calcium supplementation often overlap. This has led to investigations into the interaction between these two minerals, and whether calcium may inhibit iron absorption in the gut. OBJECTIVE: To determine the effect of various calcium salts on non-heme iron bioavailability in fasted women of childbearing age...
September 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29893871/the-nicotiana-tabacum-abc-transporter-ntpdr3-secretes-o-methylated-coumarins-in-response-to-iron-deficiency
#20
François Lefèvre, Justine Fourmeau, Mathieu Pottier, Amandine Baijot, Thomas Cornet, Javier Abadía, Ana Álvarez-Fernández, Marc Boutry
Although iron is present in large amounts in the soil, its poor solubility has entailed plants to use various strategies to facilitate its uptake. In this report, we show that expression of NtPDR3/NtABCG3, a Nicotiana tabacum plasma membrane ABC transporter, is strongly induced in the root epidermis under iron deficiency conditions. Prevention of NtPDR3 expression resulted in N. tabacum plants that were less tolerant to iron-deficient conditions, displaying stronger chlorosis and slower growth than those of the wild-type when not supplied with iron...
June 8, 2018: Journal of Experimental Botany
keyword
keyword
66545
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"