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https://www.readbyqxmd.com/read/29451472/hepcidin-and-proinflammatory-markers-in-children-with-chronic-kidney-disease-a-case-control-study
#1
Kamal Kumar Goyal, Abhijeet Saha, Puneet Kaur Sahi, Manpreet Kaur, Nand Kishore Dubey, Parul Goyal, Ashish Dutt Upadhayay
BACKGROUND: Hepcidin is the main regulator of hepcidin-ferroportin axis and is elevated in children with chronic kidney disease (CKD). Anemia of CKD and its relation to hepcidin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) in iron- and erythropoietin (EPO)-naïve, non-dialyzed children with CKD is under-studied. MATERIALS AND METHODS: This case-control study aimed to study the levels of hepcidin and other proinflammatory markers (IL-6, TNF-α, hs-CRP) and their relation with anemia in iron- and erythropoietin-naïve, non-dialysis CKD (stage 3 - 5) patients...
February 16, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29451226/final-adult-height-and-endocrine-complications-in-young-adults-with-%C3%AE-thalassemia-major-tm-who-received-oral-iron-chelation-oic-in-comparison-with-those-who-did-not-use-oic
#2
Ashraf T Soliman, Mohamed A Yassin, Vincenzo De Sanctis
BACKGROUND: Relatively little is known about endocrine function, bone mineral health, and growth during oral iron chelation therapy in β-thalassemia major patients (TM) on treatment with deferasirox. AIMS OF THE STUDY: To study the frequency of endocrine complications, IGF-1 levels and final adult standing height (FA-Ht) in patients with BTM in two groups of adult patients. PATIENTS AND METHODS: The first group (Group A; 15 patients, 6 females and 9 males) received oral iron chelation therapy (OIC) with deferasirox for 6 years before puberty; the second group (Group B;40 patients) attained the FA-Ht before the use of OIC (iron chelation therapy with deferoxamine (DFO) given subcutaneously, since the age of 2 years)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29449371/biochemical-characterization-and-essentiality-of-plasmodium-fumarate-hydratase
#3
Vijay Jayaraman, Arpitha Suryavanshi, Pavithra Kalale, Jyothirmai Kunala, Hemalatha Balaram
Plasmodium falciparum (Pf), the causative agent of malaria, has an iron-sulfur cluster-containing class I fumarate hydratase (FH) that catalyzes the interconversion of fumarate to malate, a well-known reaction in the tricarboxylic acid cycle. In humans, the same reaction is catalyzed by class II FH that has no sequence or structural homology with the class I enzyme from Plasmodium. Fumarate is generated in large quantities in the parasite as a byproduct of AMP synthesis and is converted to malate by FH and then used in the generation of the key metabolites oxaloacetate, aspartate, and pyruvate...
February 15, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29449108/effect-of-nitrogen-and-zinc-fertilization-on-zinc-and-iron-bioavailability-and-chemical-speciation-in-maize-silage
#4
Djordje Grujcic, Thomas Hesselhøj Hansen, Søren Husted, Milanka Drinic, Bal Ram Singh
Agronomic biofortification is one of the main strategies for alleviation of micronutrient deficiencies in food and feed. The objective of this study was to investigate the effect of N supply on total concentration of Zn and Fe and their chemical species in the soluble extracts of maize silage grown under field conditions. Total concentrations of Zn, Fe, Cu, Mn, S and P were measured by flow-injection inductive coupled plasma (ICP) - mass spectrometer (MS). Soluble Fe and Zn were extracted and analyzed by size exclusion-inductively coupled plasma mass spectrometry...
February 11, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29447741/the-burden-of-iron-deficiency-in-heart-failure-therapeutic-approach
#5
REVIEW
Bruno M L Rocha, Gonçalo J L Cunha, Luiz F Menezes Falcão
Heart failure (HF) is highlighted by its burdening symptom-limited exercise capacity and recurrent hospitalizations. Despite substantial advances regarding disease-modifying drugs in HF with reduced ejection fraction, additional therapeutic strategies to improve quality of life are invaluable. Currently, iron deficiency (ID) is overwhelmingly recognized in over 30% to 50% of patients with stable chronic HF, which worsens prognosis. The established pathophysiological mechanisms of progressive HF may be intertwined with increasing myocardial iron scarcity, wherein one begets the other...
February 20, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29447493/vitamin-d-and-ferritin-correlation-with-chronic-neck-pain-using-standard-statistics-and-a-novel-artificial-neural-network-prediction-model
#6
Haytham Eloqayli, Ali Al-Yousef, Raid Jaradat
AIM: Despite the high prevalence of chronic neck pain, there is limited consensus about the primary etiology, risk factors, diagnostic criteria and therapeutic outcome. Here, we aimed to determine if Ferritin and Vitamin D are modifiable risk factors with chronic neck pain using slandered statistics and artificial intelligence neural network (ANN). METHODS: Fifty-four patients with chronic neck pain treated between February 2016 and August 2016 in King Abdullah University Hospital and 54 patients age matched controls undergoing outpatient or minor procedures were enrolled...
February 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29447378/trace-metal-metabolism-in-plants
#7
Elisa Andresen, Edgar Peiter, Hendrik Küpper
Many trace metals are essential micronutrients, but also potent toxins. Due to natural and anthropogenic causes, vastly different trace metal concentrations occur in various habitats, ranging from deficient to toxic levels. Therefore, one focus of plant research is on the response to trace metals in terms of uptake, transport, sequestration, speciation, physiological use, deficiency, toxicity, and detoxification. In this review, we cover most of these aspects for the essential micronutrients copper, iron, manganese, molybdenum, nickel, and zinc to provide a broader overview than found in other recent reviews, to cross-link aspects of knowledge in this very active research field that are often seen in a separated way...
February 13, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29446943/fe-2-o-3-promoted-intermolecular-chlorotrifluoromethylthiolation-of-alkenes
#8
Yimin Jia, Hongmei Qin, Na Wang, Zhong-Xing Jiang, Zhigang Yang
A simple, convenient method for intermolecular chlorotrifluoromethylthiolation of alkenes by using a low-cost and more abundant iron catalyst has been developed. This protocol provides a straightforward way to synthesize a variety of useful SCF 3 -containing chlorides from a wide range of alkenes, including electron-deficient, aromatic, and unactivated alkenes. Mechanistic studies indicate that this is a free radical transformation, and the stronger electrophilic trifluoromethylthiolating reagent CF 3 SCl was generated in situ under the employed conditions...
February 15, 2018: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29446792/anemia-in-childhood
#9
Leah Khan
Anemia is a pervasive problem in pediatrics and evaluating for it is considered part of standard care for all pediatric patients. If left untreated, it can cause significant problems for children and many of the detriments can be long lasting. Although iron deficiency anemia is the most common form of pediatric anemia, it is important to keep the broad differential in mind for those in whom the history suggests an alternate diagnosis or who do not respond to standard treatment with iron supplementation. This article gives a basic overview of anemia in children with a focus on iron deficiency...
February 1, 2018: Pediatric Annals
https://www.readbyqxmd.com/read/29444509/associations-between-intravenous-iron-inflammation-and-fgf23-in-non-dialysis-patients-with-chronic-kidney-disease-stages-3-5
#10
Katarzyna Muras-Szwedziak, Michal Nowicki
BACKGROUND/AIMS: Both iron deficiency and chronic inflammation are highly prevalent in patients with chronic kidney disease (CKD). The effect of intravenous iron infusion on mineral metabolism in CKD may be modified by inflammation. Intravenous iron theraphy may reduce peripheral degradation, secretion, clearence of iFGF23 and lead to hypophosphatemia. The aim of the study was to evaluate the effect of intravenous iron on mineral metabolism in CKD patients. METHODS: 35 non-dialysis patients with CKD stages 3-5...
February 8, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29440920/oral-versus-intravenous-iron-therapy-in-patients-with-inflammatory-bowel-disease-and-iron-deficiency-with-and-without-anemia-in-germany-a-real-world-evidence-analysis
#11
Jürgen Stein, Jennifer Scarlet Haas, Siew Hwa Ong, Kathrin Borchert, Thomas Hardt, Elmira Lechat, Kerry Nip, Douglas Foerster, Sebastian Braun, Daniel C Baumgart
Background: Iron-deficiency anemia and iron deficiency are common comorbidities associated with inflammatory bowel disease (IBD) resulting in impaired quality of life and high health care costs. Intravenous iron has shown clinical benefit compared to oral iron therapy. Aim: This study aimed to compare health care outcomes and costs after oral vs intravenous iron treatment for IBD patients with iron deficiency or iron deficiency anemia (ID/A) in Germany. Methods: IBD patients with ID/A were identified by ICD-10-GM codes and newly commenced iron treatment via ATC codes in 2013 within the InGef (formerly Health Risk Institute) research claims database...
2018: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/29439253/positive-iron-balance-in-chronic-kidney-disease-how-much-is-too-much-and-how-to-tell
#12
Jay B Wish, George R Aronoff, Bruce R Bacon, Carlo Brugnara, Kai-Uwe Eckardt, Tomas Ganz, Iain C Macdougall, Julio Núñez, Adam J Perahia, John C Wood
BACKGROUND: Regulation of body iron occurs at cellular, tissue, and systemic levels. In healthy individuals, iron absorption and losses are minimal, creating a virtually closed system. In the setting of chronic kidney disease and hemodialysis (HD), increased iron losses, reduced iron absorption, and limited iron availability lead to iron deficiency. Intravenous (IV) iron therapy is frequently prescribed to replace lost iron, but determining an individual's iron balance and stores can be challenging and imprecise, contributing to uncertainty about the long-term safety of IV iron therapy...
February 13, 2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29436580/iron-limitation-promotes-the-atrophy-of-skeletal-myocytes-whereas-iron-supplementation-prevents-this-process-in-the-hypoxic-conditions
#13
Kamil Kobak, Monika Kasztura, Magdalena Dziegala, Jacek Bania, Violetta Kapuśniak, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowska
There is clinical evidence that patients with heart failure and concomitant iron deficiency have increased skeletal muscle fatigability and impaired exercise tolerance. It was expected that a skeletal muscle cell line subjected to different degrees of iron availability and/or concomitant hypoxia would demonstrate changes in cell morphology and in the expression of atrophy markers. L6G8C5 rat skeletal myocytes were cultured in normoxia or hypoxia at optimal, reduced or increased iron concentrations. Experiments were performed to evaluate the iron content in cells, cell morphology, and the expression of muscle specific atrophy markers [Atrogin1 and muscle‑specific RING‑finger 1 (MuRF1)], a gene associated with the atrophy/hypertrophy balance [mothers against decapentaplegic homolog 4 (SMAD4)] and a muscle class‑III intermediate filament protein (Desmin) at the mRNA and protein level...
February 12, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29435875/a-prospective-study-to-evaluate-the-role-of-duodenal-bulb-biopsy-in-the-diagnosis-of-celiac-disease
#14
Bhanwar Singh Dhandhu, Gaurav Kumar Gupta, Shashank J Wanjari, Nidhi Sharma, Sandeep Nijhawan
BACKGROUND: Celiac disease (CeD) requires a biopsy from the small intestine to confirm the diagnosis. Conventionally, duodenal bulb (D1) was avoided as a biopsy site due to histological confounding factors at this site. However, sometimes, the bulb mucosa is the only affected site. The aim of the present study was to assess changes in duodenal bulb histology and compare it to distal duodenal histology and to analyze whether the addition of duodenal bulb biopsy increases the diagnostic yield of the CeD...
February 13, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29435325/psychological-distress-iron-deficiency-active-disease-and-female-gender-are-independent-risk-factors-for-fatigue-in-patients-with-ulcerative-colitis
#15
Börje Jonefjäll, Magnus Simrén, Anders Lasson, Lena Öhman, Hans Strid
Background: Patients with ulcerative colitis often report fatigue. Objectives: To investigate prevalence of and risk factors for fatigue in patients with ulcerative colitis with active disease and during deep remission. Methods: In this cross-sectional study, disease activity was evaluated with endoscopy and calprotectin, and patients were classified as having active disease (n = 133) or being in deep remission (n = 155). Blood samples were analysed to assess anaemia, iron deficiency and systemic immune activity...
February 2018: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29433755/vitamin-mineral-and-micronutrient-status-in-patients-with-classical-phenylketonuria
#16
Engin Kose, Nur Arslan
BACKGROUND & AIMS: Strict low-phenylalanine diet is associated with an increased risk of developing micronutrient deficiencies in patients with phenylketonuria (PKU). The primary objective of this single-center, case-control study was to assess the nutritional parameters of patients with PKU on strict low-phenylalanine diet without vitamin and mineral supplementation compared to a healthy control group. Secondary objective was to identify the adequacy of vitamin/mineral supplementation in phenylalanine-free (Phe-free) amino acid formulas...
February 9, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29433459/assessment-of-peripheral-blood-lymphocyte-subsets-in-children-with-iron-deficiency-anemia
#17
Sanaa S Aly, Hanan M Fayed, Ahlam M Ismail, Gehan L Abdel Hakeem
BACKGROUND: Iron plays an important role in body defense and essential for normal immune system development where its deficiency may result in an inadequate immune response. We aimed to assess the lymphocyte subsets in childhood iron deficiency anemia (IDA) with their laboratory correlations. METHODS: Fifty IDA (< 18 years) and 25 age and sex-matched healthy children were enrolled and a complete history was obtained and clinical examination was performed. Complete blood count, serum iron, total iron binding capacity and serum ferritin, were performed...
February 12, 2018: BMC Pediatrics
https://www.readbyqxmd.com/read/29432419/an-efficient-bayesian-meta-analysis-approach-for-studying-cross-phenotype-genetic-associations
#18
Arunabha Majumdar, Tanushree Haldar, Sourabh Bhattacharya, John S Witte
Simultaneous analysis of genetic associations with multiple phenotypes may reveal shared genetic susceptibility across traits (pleiotropy). For a locus exhibiting overall pleiotropy, it is important to identify which specific traits underlie this association. We propose a Bayesian meta-analysis approach (termed CPBayes) that uses summary-level data across multiple phenotypes to simultaneously measure the evidence of aggregate-level pleiotropic association and estimate an optimal subset of traits associated with the risk locus...
February 12, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29432304/anemia-in-adolescents-and-young-adult-patients-with-congenital-heart-disease
#19
Juan L Rodríguez-Hernández, Fayna Rodríguez-González, Efrén Martínez-Quintana
INTRODUCTION: Despite anemia in acquired heart disease being a common problem, little is known in patients with congenital heart disease (CHD). METHODS: In total, 544 consecutive stable noncyanotic CHD patients were studied to determine demographic, clinical, and analytic parameters. Anemia was defined as a condition in which hemoglobin concentration was <13 g/dL in male individuals and <12 g/dL in female individuals. RESULTS: In total, 49 (9%) CHD patients had anemia...
February 9, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29431403/mildly-elevated-liver-transaminase-levels-causes-and-evaluation
#20
Robert C Oh, Thomas R Hustead, Syed M Ali, Matthew W Pantsari
Mild, asymptomatic elevations (less than five times the upper limit of normal) of alanine transaminase and aspartate transaminase levels are common in primary care. It is estimated that approximately 10% of the U.S. population has elevated transaminase levels. An approach based on the prevalence of diseases that cause asymptomatic transaminase elevations can help clinicians efficiently identify common and serious liver disease. The most common causes of elevated transaminase levels are nonalcoholic fatty liver disease and alcoholic liver disease...
December 1, 2017: American Family Physician
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